-- dump date 20140619_024438 -- class Genbank::misc_feature -- table misc_feature_note -- id note 330214000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 330214000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 330214000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000004 Walker A motif; other site 330214000005 ATP binding site [chemical binding]; other site 330214000006 Walker B motif; other site 330214000007 arginine finger; other site 330214000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 330214000009 DnaA box-binding interface [nucleotide binding]; other site 330214000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 330214000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 330214000012 putative DNA binding surface [nucleotide binding]; other site 330214000013 dimer interface [polypeptide binding]; other site 330214000014 beta-clamp/clamp loader binding surface; other site 330214000015 beta-clamp/translesion DNA polymerase binding surface; other site 330214000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 330214000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214000018 ATP binding site [chemical binding]; other site 330214000019 Mg2+ binding site [ion binding]; other site 330214000020 G-X-G motif; other site 330214000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 330214000022 anchoring element; other site 330214000023 dimer interface [polypeptide binding]; other site 330214000024 ATP binding site [chemical binding]; other site 330214000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 330214000026 active site 330214000027 putative metal-binding site [ion binding]; other site 330214000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 330214000029 DNA gyrase subunit A; Validated; Region: PRK05560 330214000030 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 330214000031 CAP-like domain; other site 330214000032 active site 330214000033 primary dimer interface [polypeptide binding]; other site 330214000034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 330214000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 330214000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 330214000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 330214000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 330214000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 330214000040 Protein of unknown function (DUF721); Region: DUF721; pfam05258 330214000041 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 330214000042 SmpB-tmRNA interface; other site 330214000043 DoxX; Region: DoxX; pfam07681 330214000044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214000045 NmrA-like family; Region: NmrA; pfam05368 330214000046 NAD(P) binding site [chemical binding]; other site 330214000047 active site 330214000048 Pirin-related protein [General function prediction only]; Region: COG1741 330214000049 Pirin; Region: Pirin; pfam02678 330214000050 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 330214000051 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 330214000052 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 330214000053 catalytic residues [active] 330214000054 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214000055 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 330214000056 active site 330214000057 metal binding site [ion binding]; metal-binding site 330214000058 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 330214000059 iron-sulfur cluster [ion binding]; other site 330214000060 [2Fe-2S] cluster binding site [ion binding]; other site 330214000061 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 330214000062 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 330214000063 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 330214000064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214000065 putative active site [active] 330214000066 putative metal binding site [ion binding]; other site 330214000067 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 330214000068 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 330214000069 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 330214000070 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 330214000071 FAD binding pocket [chemical binding]; other site 330214000072 conserved FAD binding motif [chemical binding]; other site 330214000073 phosphate binding motif [ion binding]; other site 330214000074 beta-alpha-beta structure motif; other site 330214000075 NAD binding pocket [chemical binding]; other site 330214000076 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214000077 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 330214000078 FAD binding domain; Region: FAD_binding_4; pfam01565 330214000079 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 330214000080 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 330214000081 catalytic Zn binding site [ion binding]; other site 330214000082 NAD binding site [chemical binding]; other site 330214000083 structural Zn binding site [ion binding]; other site 330214000084 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 330214000085 NADH(P)-binding; Region: NAD_binding_10; pfam13460 330214000086 NAD binding site [chemical binding]; other site 330214000087 substrate binding site [chemical binding]; other site 330214000088 putative active site [active] 330214000089 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 330214000090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214000091 Protein of unknown function DUF86; Region: DUF86; cl01031 330214000092 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 330214000093 active site 330214000094 NTP binding site [chemical binding]; other site 330214000095 metal binding triad [ion binding]; metal-binding site 330214000096 antibiotic binding site [chemical binding]; other site 330214000097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214000098 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214000099 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 330214000100 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000102 Walker A motif; other site 330214000103 ATP binding site [chemical binding]; other site 330214000104 Walker B motif; other site 330214000105 arginine finger; other site 330214000106 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 330214000107 dimer interface [polypeptide binding]; other site 330214000108 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214000109 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 330214000110 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214000111 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 330214000112 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 330214000113 Walker A/P-loop; other site 330214000114 ATP binding site [chemical binding]; other site 330214000115 Q-loop/lid; other site 330214000116 ABC transporter signature motif; other site 330214000117 Walker B; other site 330214000118 D-loop; other site 330214000119 H-loop/switch region; other site 330214000120 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 330214000121 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 330214000122 Walker A/P-loop; other site 330214000123 ATP binding site [chemical binding]; other site 330214000124 Q-loop/lid; other site 330214000125 ABC transporter signature motif; other site 330214000126 Walker B; other site 330214000127 D-loop; other site 330214000128 H-loop/switch region; other site 330214000129 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 330214000130 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 330214000131 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 330214000132 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 330214000133 Predicted membrane protein [Function unknown]; Region: COG2259 330214000134 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 330214000135 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 330214000136 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 330214000137 dimer interface [polypeptide binding]; other site 330214000138 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 330214000139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214000140 motif II; other site 330214000141 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 330214000142 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 330214000143 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 330214000144 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 330214000145 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 330214000146 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 330214000147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214000148 motif II; other site 330214000149 maltose O-acetyltransferase; Provisional; Region: PRK10092 330214000150 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 330214000151 active site 330214000152 substrate binding site [chemical binding]; other site 330214000153 trimer interface [polypeptide binding]; other site 330214000154 CoA binding site [chemical binding]; other site 330214000155 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 330214000156 putative FMN binding site [chemical binding]; other site 330214000157 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 330214000158 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 330214000159 NADP binding site [chemical binding]; other site 330214000160 homodimer interface [polypeptide binding]; other site 330214000161 active site 330214000162 substrate binding site [chemical binding]; other site 330214000163 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 330214000164 homotrimer interaction site [polypeptide binding]; other site 330214000165 putative active site [active] 330214000166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 330214000167 endonuclease III; Region: ENDO3c; smart00478 330214000168 minor groove reading motif; other site 330214000169 helix-hairpin-helix signature motif; other site 330214000170 substrate binding pocket [chemical binding]; other site 330214000171 active site 330214000172 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 330214000173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 330214000174 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 330214000175 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 330214000176 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 330214000177 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 330214000178 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 330214000179 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 330214000180 active site 330214000181 homotetramer interface [polypeptide binding]; other site 330214000182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 330214000183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 330214000184 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 330214000185 dimerization interface [polypeptide binding]; other site 330214000186 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 330214000187 folate/biopterin transporter; Region: fbt; TIGR00788 330214000188 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 330214000189 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 330214000190 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 330214000191 active site residue [active] 330214000192 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 330214000193 hypothetical protein; Provisional; Region: PRK02237 330214000194 putative transcriptional regulator MerR; Provisional; Region: PRK13752 330214000195 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 330214000196 DNA binding residues [nucleotide binding] 330214000197 dimer interface [polypeptide binding]; other site 330214000198 mercury binding site [ion binding]; other site 330214000199 putative mercuric transport protein; Provisional; Region: PRK13751 330214000200 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 330214000201 metal-binding site [ion binding] 330214000202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 330214000203 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 330214000204 catalytic residues [active] 330214000205 catalytic nucleophile [active] 330214000206 Presynaptic Site I dimer interface [polypeptide binding]; other site 330214000207 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 330214000208 Synaptic Flat tetramer interface [polypeptide binding]; other site 330214000209 Synaptic Site I dimer interface [polypeptide binding]; other site 330214000210 DNA binding site [nucleotide binding] 330214000211 Recombinase; Region: Recombinase; pfam07508 330214000212 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 330214000213 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 330214000214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 330214000215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214000216 non-specific DNA binding site [nucleotide binding]; other site 330214000217 salt bridge; other site 330214000218 sequence-specific DNA binding site [nucleotide binding]; other site 330214000219 AAA domain; Region: AAA_24; pfam13479 330214000220 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 330214000221 P63C domain; Region: P63C; pfam10546 330214000222 hypothetical protein; Validated; Region: PRK07078 330214000223 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 330214000224 active site 330214000225 metal binding site [ion binding]; metal-binding site 330214000226 interdomain interaction site; other site 330214000227 D5 N terminal like; Region: D5_N; smart00885 330214000228 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 330214000229 ParB-like nuclease domain; Region: ParBc; pfam02195 330214000230 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 330214000231 DNA methylase; Region: N6_N4_Mtase; pfam01555 330214000232 ParB-like nuclease domain; Region: ParBc; pfam02195 330214000233 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 330214000234 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 330214000235 DNA methylase; Region: N6_N4_Mtase; pfam01555 330214000236 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 330214000237 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 330214000238 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 330214000239 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 330214000240 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 330214000241 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 330214000242 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 330214000243 tandem repeat interface [polypeptide binding]; other site 330214000244 oligomer interface [polypeptide binding]; other site 330214000245 active site residues [active] 330214000246 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 330214000247 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 330214000248 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 330214000249 Putative phage tail protein; Region: Phage-tail_3; pfam13550 330214000250 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214000251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214000252 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 330214000253 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 330214000254 catalytic residues [active] 330214000255 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 330214000256 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 330214000257 PLD-like domain; Region: PLDc_2; pfam13091 330214000258 putative active site [active] 330214000259 catalytic site [active] 330214000260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 330214000261 putative Mg++ binding site [ion binding]; other site 330214000262 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 330214000263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214000264 nucleotide binding region [chemical binding]; other site 330214000265 ATP-binding site [chemical binding]; other site 330214000266 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 330214000267 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 330214000268 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 330214000269 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 330214000270 Protein of unknown function (DUF499); Region: DUF499; pfam04465 330214000271 Fn3 associated; Region: Fn3_assoc; pfam13287 330214000272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 330214000273 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 330214000274 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 330214000275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214000276 ATP binding site [chemical binding]; other site 330214000277 putative Mg++ binding site [ion binding]; other site 330214000278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 330214000279 nucleotide binding region [chemical binding]; other site 330214000280 ATP-binding site [chemical binding]; other site 330214000281 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 330214000282 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 330214000283 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 330214000284 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 330214000285 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 330214000286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214000287 S-adenosylmethionine binding site [chemical binding]; other site 330214000288 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 330214000289 heme-binding site [chemical binding]; other site 330214000290 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 330214000291 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 330214000292 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 330214000293 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 330214000294 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 330214000295 active site 330214000296 homotetramer interface [polypeptide binding]; other site 330214000297 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 330214000298 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 330214000299 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 330214000300 ADP-ribose binding site [chemical binding]; other site 330214000301 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 330214000302 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 330214000303 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 330214000304 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 330214000305 Mechanosensitive ion channel; Region: MS_channel; pfam00924 330214000306 FOG: CBS domain [General function prediction only]; Region: COG0517 330214000307 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214000308 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 330214000309 aromatic arch; other site 330214000310 DCoH dimer interaction site [polypeptide binding]; other site 330214000311 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 330214000312 DCoH tetramer interaction site [polypeptide binding]; other site 330214000313 substrate binding site [chemical binding]; other site 330214000314 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 330214000315 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 330214000316 B12 binding site [chemical binding]; other site 330214000317 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 330214000318 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 330214000319 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 330214000320 active site 330214000321 dimerization interface [polypeptide binding]; other site 330214000322 DASH complex subunit Spc34; Region: DASH_Spc34; pfam08657 330214000323 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 330214000324 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 330214000325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214000326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000327 active site 330214000328 phosphorylation site [posttranslational modification] 330214000329 intermolecular recognition site; other site 330214000330 dimerization interface [polypeptide binding]; other site 330214000331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214000332 DNA binding residues [nucleotide binding] 330214000333 dimerization interface [polypeptide binding]; other site 330214000334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214000335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 330214000336 Histidine kinase; Region: HisKA_3; pfam07730 330214000337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214000338 ATP binding site [chemical binding]; other site 330214000339 Mg2+ binding site [ion binding]; other site 330214000340 G-X-G motif; other site 330214000341 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 330214000342 ATP cone domain; Region: ATP-cone; pfam03477 330214000343 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 330214000344 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 330214000345 dimer interface [polypeptide binding]; other site 330214000346 active site 330214000347 glycine-pyridoxal phosphate binding site [chemical binding]; other site 330214000348 folate binding site [chemical binding]; other site 330214000349 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 330214000350 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 330214000351 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 330214000352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214000353 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 330214000354 active site 330214000355 DNA binding site [nucleotide binding] 330214000356 Int/Topo IB signature motif; other site 330214000357 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 330214000358 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 330214000359 multiple promoter invertase; Provisional; Region: mpi; PRK13413 330214000360 catalytic residues [active] 330214000361 catalytic nucleophile [active] 330214000362 Presynaptic Site I dimer interface [polypeptide binding]; other site 330214000363 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 330214000364 Synaptic Flat tetramer interface [polypeptide binding]; other site 330214000365 Synaptic Site I dimer interface [polypeptide binding]; other site 330214000366 DNA binding site [nucleotide binding] 330214000367 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 330214000368 Cytochrome P450; Region: p450; pfam00067 330214000369 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 330214000370 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 330214000371 Protein of unknown function, DUF393; Region: DUF393; pfam04134 330214000372 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 330214000373 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 330214000374 DNA binding residues [nucleotide binding] 330214000375 B12 binding domain; Region: B12-binding_2; pfam02607 330214000376 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 330214000377 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214000378 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214000379 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214000380 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214000381 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214000382 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214000383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214000384 TIGR01777 family protein; Region: yfcH 330214000385 NAD(P) binding site [chemical binding]; other site 330214000386 active site 330214000387 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 330214000388 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 330214000389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214000390 TPR motif; other site 330214000391 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 330214000392 DNA photolyase; Region: DNA_photolyase; pfam00875 330214000393 Protein of unknown function (DUF523); Region: DUF523; pfam04463 330214000394 Uncharacterized conserved protein [Function unknown]; Region: COG3272 330214000395 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 330214000396 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 330214000397 putative active site [active] 330214000398 SnoaL-like domain; Region: SnoaL_2; pfam12680 330214000399 short chain dehydrogenase; Provisional; Region: PRK06101 330214000400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214000401 NAD(P) binding site [chemical binding]; other site 330214000402 active site 330214000403 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 330214000404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 330214000405 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 330214000406 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 330214000407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214000408 S-adenosylmethionine binding site [chemical binding]; other site 330214000409 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 330214000410 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 330214000411 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 330214000412 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 330214000413 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 330214000414 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214000415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214000416 active site 330214000417 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 330214000418 active site residue [active] 330214000419 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 330214000420 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 330214000421 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214000422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000423 active site 330214000424 phosphorylation site [posttranslational modification] 330214000425 intermolecular recognition site; other site 330214000426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214000427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214000428 dimer interface [polypeptide binding]; other site 330214000429 phosphorylation site [posttranslational modification] 330214000430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214000431 ATP binding site [chemical binding]; other site 330214000432 Mg2+ binding site [ion binding]; other site 330214000433 G-X-G motif; other site 330214000434 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214000435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000436 active site 330214000437 phosphorylation site [posttranslational modification] 330214000438 intermolecular recognition site; other site 330214000439 dimerization interface [polypeptide binding]; other site 330214000440 Response regulator receiver domain; Region: Response_reg; pfam00072 330214000441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000442 active site 330214000443 phosphorylation site [posttranslational modification] 330214000444 intermolecular recognition site; other site 330214000445 dimerization interface [polypeptide binding]; other site 330214000446 CHASE3 domain; Region: CHASE3; pfam05227 330214000447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214000448 dimer interface [polypeptide binding]; other site 330214000449 phosphorylation site [posttranslational modification] 330214000450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214000451 ATP binding site [chemical binding]; other site 330214000452 Mg2+ binding site [ion binding]; other site 330214000453 G-X-G motif; other site 330214000454 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 330214000455 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214000456 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 330214000457 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214000458 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 330214000459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214000460 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 330214000461 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 330214000462 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214000463 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 330214000464 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 330214000465 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 330214000466 4Fe-4S binding domain; Region: Fer4; cl02805 330214000467 4Fe-4S binding domain; Region: Fer4; pfam00037 330214000468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 330214000469 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 330214000470 catalytic loop [active] 330214000471 iron binding site [ion binding]; other site 330214000472 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 330214000473 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214000474 molybdopterin cofactor binding site; other site 330214000475 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 330214000476 molybdopterin cofactor binding site; other site 330214000477 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 330214000478 NADH dehydrogenase subunit D; Validated; Region: PRK06075 330214000479 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 330214000480 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 330214000481 NADH dehydrogenase subunit B; Validated; Region: PRK06411 330214000482 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 330214000483 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214000484 ligand binding site [chemical binding]; other site 330214000485 primosome assembly protein PriA; Validated; Region: PRK05580 330214000486 Response regulator receiver domain; Region: Response_reg; pfam00072 330214000487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000488 active site 330214000489 phosphorylation site [posttranslational modification] 330214000490 intermolecular recognition site; other site 330214000491 dimerization interface [polypeptide binding]; other site 330214000492 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214000493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214000494 putative active site [active] 330214000495 heme pocket [chemical binding]; other site 330214000496 PAS domain; Region: PAS_8; pfam13188 330214000497 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214000498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214000499 dimer interface [polypeptide binding]; other site 330214000500 phosphorylation site [posttranslational modification] 330214000501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214000502 ATP binding site [chemical binding]; other site 330214000503 G-X-G motif; other site 330214000504 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 330214000505 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 330214000506 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 330214000507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214000508 FeS/SAM binding site; other site 330214000509 multifunctional aminopeptidase A; Provisional; Region: PRK00913 330214000510 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 330214000511 interface (dimer of trimers) [polypeptide binding]; other site 330214000512 Substrate-binding/catalytic site; other site 330214000513 Zn-binding sites [ion binding]; other site 330214000514 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 330214000515 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 330214000516 amino acid transporter; Region: 2A0306; TIGR00909 330214000517 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 330214000518 Peptidase C26; Region: Peptidase_C26; pfam07722 330214000519 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 330214000520 catalytic triad [active] 330214000521 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 330214000522 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 330214000523 active site 330214000524 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 330214000525 HEAT repeats; Region: HEAT_2; pfam13646 330214000526 HEAT repeats; Region: HEAT_2; pfam13646 330214000527 PilZ domain; Region: PilZ; pfam07238 330214000528 PilZ domain; Region: PilZ; cl01260 330214000529 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 330214000530 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 330214000531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000532 Walker A motif; other site 330214000533 ATP binding site [chemical binding]; other site 330214000534 Walker B motif; other site 330214000535 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 330214000536 Clp protease; Region: CLP_protease; pfam00574 330214000537 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 330214000538 oligomer interface [polypeptide binding]; other site 330214000539 active site residues [active] 330214000540 trigger factor; Region: tig; TIGR00115 330214000541 Protein of unknown function (DUF708); Region: DUF708; pfam05341 330214000542 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 330214000543 HEAT-like repeat; Region: HEAT_EZ; pfam13513 330214000544 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 330214000545 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 330214000546 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 330214000547 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214000548 ligand binding site [chemical binding]; other site 330214000549 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 330214000550 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214000551 ligand binding site [chemical binding]; other site 330214000552 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 330214000553 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 330214000554 Protein of unknown function, DUF481; Region: DUF481; pfam04338 330214000555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214000556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214000557 DNA binding residues [nucleotide binding] 330214000558 dimerization interface [polypeptide binding]; other site 330214000559 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 330214000560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000561 Walker A motif; other site 330214000562 ATP binding site [chemical binding]; other site 330214000563 Walker B motif; other site 330214000564 arginine finger; other site 330214000565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214000566 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 330214000567 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 330214000568 Rab subfamily motif 1 (RabSF1); other site 330214000569 G1 box; other site 330214000570 GTP/Mg2+ binding site [chemical binding]; other site 330214000571 Rab subfamily motif 2 (RabSF2); other site 330214000572 Switch I region; other site 330214000573 G2 box; other site 330214000574 effector interaction site; other site 330214000575 GDI interaction site; other site 330214000576 Rab family motif 1 (RabF1); other site 330214000577 GEF interaction site [polypeptide binding]; other site 330214000578 Rab family motif 2 (RabF2); other site 330214000579 G3 box; other site 330214000580 Switch II region; other site 330214000581 Rab family motif 3 (RabF3); other site 330214000582 Rab family motif 4 (RabF4); other site 330214000583 Rab family motif 5 (RabF5); other site 330214000584 Rab subfamily motif 3 (RabSF3); other site 330214000585 G4 box; other site 330214000586 G5 box; other site 330214000587 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214000588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 330214000589 ligand binding site [chemical binding]; other site 330214000590 Mechanosensitive ion channel; Region: MS_channel; pfam00924 330214000591 AsmA family; Region: AsmA; pfam05170 330214000592 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 330214000593 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 330214000594 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 330214000595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000596 Walker A motif; other site 330214000597 ATP binding site [chemical binding]; other site 330214000598 Walker B motif; other site 330214000599 arginine finger; other site 330214000600 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 330214000601 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 330214000602 hypothetical protein; Validated; Region: PRK00153 330214000603 recombination protein RecR; Reviewed; Region: recR; PRK00076 330214000604 RecR protein; Region: RecR; pfam02132 330214000605 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 330214000606 putative active site [active] 330214000607 putative metal-binding site [ion binding]; other site 330214000608 tetramer interface [polypeptide binding]; other site 330214000609 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 330214000610 TPR repeat; Region: TPR_11; pfam13414 330214000611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214000612 binding surface 330214000613 TPR motif; other site 330214000614 PIN domain; Region: PIN_3; cl17397 330214000615 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 330214000616 TIR domain; Region: TIR_2; pfam13676 330214000617 Replication initiation factor; Region: Rep_trans; pfam02486 330214000618 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214000619 integrase; Provisional; Region: int; PHA02601 330214000620 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 330214000621 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214000622 active site 330214000623 DNA binding site [nucleotide binding] 330214000624 Int/Topo IB signature motif; other site 330214000625 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 330214000626 Glucose inhibited division protein A; Region: GIDA; pfam01134 330214000627 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214000628 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 330214000629 active site 330214000630 DNA binding site [nucleotide binding] 330214000631 Int/Topo IB signature motif; other site 330214000632 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 330214000633 active site 330214000634 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 330214000635 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 330214000636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000637 Walker A motif; other site 330214000638 ATP binding site [chemical binding]; other site 330214000639 Walker B motif; other site 330214000640 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 330214000641 Walker B motif; other site 330214000642 arginine finger; other site 330214000643 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 330214000644 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 330214000645 feedback inhibition sensing region; other site 330214000646 homohexameric interface [polypeptide binding]; other site 330214000647 carbamate kinase; Reviewed; Region: PRK12686 330214000648 nucleotide binding site [chemical binding]; other site 330214000649 N-acetyl-L-glutamate binding site [chemical binding]; other site 330214000650 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 330214000651 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 330214000652 trimer interface [polypeptide binding]; other site 330214000653 putative metal binding site [ion binding]; other site 330214000654 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 330214000655 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 330214000656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214000657 FeS/SAM binding site; other site 330214000658 TRAM domain; Region: TRAM; cl01282 330214000659 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 330214000660 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214000661 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214000662 protein binding site [polypeptide binding]; other site 330214000663 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214000664 protein binding site [polypeptide binding]; other site 330214000665 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 330214000666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214000667 dimerization interface [polypeptide binding]; other site 330214000668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214000669 dimer interface [polypeptide binding]; other site 330214000670 phosphorylation site [posttranslational modification] 330214000671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214000672 ATP binding site [chemical binding]; other site 330214000673 Mg2+ binding site [ion binding]; other site 330214000674 G-X-G motif; other site 330214000675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 330214000676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000677 active site 330214000678 phosphorylation site [posttranslational modification] 330214000679 intermolecular recognition site; other site 330214000680 dimerization interface [polypeptide binding]; other site 330214000681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 330214000682 DNA binding site [nucleotide binding] 330214000683 Peptidase family M48; Region: Peptidase_M48; pfam01435 330214000684 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 330214000685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 330214000686 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 330214000687 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 330214000688 TPR repeat; Region: TPR_11; pfam13414 330214000689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214000690 TPR motif; other site 330214000691 binding surface 330214000692 TPR repeat; Region: TPR_11; pfam13414 330214000693 L-aspartate oxidase; Provisional; Region: PRK06175 330214000694 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 330214000695 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 330214000696 glycine dehydrogenase; Provisional; Region: PRK05367 330214000697 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 330214000698 tetramer interface [polypeptide binding]; other site 330214000699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214000700 catalytic residue [active] 330214000701 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 330214000702 tetramer interface [polypeptide binding]; other site 330214000703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214000704 catalytic residue [active] 330214000705 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 330214000706 active site 330214000707 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 330214000708 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 330214000709 substrate binding site [chemical binding]; other site 330214000710 dimer interface [polypeptide binding]; other site 330214000711 ATP binding site [chemical binding]; other site 330214000712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214000713 TPR motif; other site 330214000714 binding surface 330214000715 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 330214000716 active site 330214000717 SUMO-1 interface [polypeptide binding]; other site 330214000718 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 330214000719 dimer interface [polypeptide binding]; other site 330214000720 ADP-ribose binding site [chemical binding]; other site 330214000721 active site 330214000722 nudix motif; other site 330214000723 metal binding site [ion binding]; metal-binding site 330214000724 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 330214000725 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 330214000726 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 330214000727 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 330214000728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 330214000729 FIST N domain; Region: FIST; pfam08495 330214000730 FIST C domain; Region: FIST_C; pfam10442 330214000731 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 330214000732 homodimer interface [polypeptide binding]; other site 330214000733 homotetramer interface [polypeptide binding]; other site 330214000734 active site pocket [active] 330214000735 cleavage site 330214000736 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 330214000737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 330214000738 Beta-Casp domain; Region: Beta-Casp; smart01027 330214000739 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 330214000740 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 330214000741 flagellin; Validated; Region: PRK08026 330214000742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 330214000743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214000744 Coenzyme A binding pocket [chemical binding]; other site 330214000745 Protein of unknown function (DUF502); Region: DUF502; cl01107 330214000746 Trm112p-like protein; Region: Trm112p; cl01066 330214000747 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 330214000748 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 330214000749 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214000750 active site 330214000751 DNA binding site [nucleotide binding] 330214000752 Int/Topo IB signature motif; other site 330214000753 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214000754 Replication initiation factor; Region: Rep_trans; pfam02486 330214000755 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 330214000756 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 330214000757 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 330214000758 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 330214000759 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 330214000760 Protein of unknown function DUF58; Region: DUF58; pfam01882 330214000761 MoxR-like ATPases [General function prediction only]; Region: COG0714 330214000762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214000763 Walker A motif; other site 330214000764 ATP binding site [chemical binding]; other site 330214000765 Walker B motif; other site 330214000766 arginine finger; other site 330214000767 Protein of unknown function, DUF399; Region: DUF399; pfam04187 330214000768 Uncharacterized conserved protein [Function unknown]; Region: COG4715 330214000769 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 330214000770 active site 330214000771 catalytic triad [active] 330214000772 oxyanion hole [active] 330214000773 switch loop; other site 330214000774 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 330214000775 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 330214000776 Walker A/P-loop; other site 330214000777 ATP binding site [chemical binding]; other site 330214000778 Q-loop/lid; other site 330214000779 ABC transporter signature motif; other site 330214000780 Walker B; other site 330214000781 D-loop; other site 330214000782 H-loop/switch region; other site 330214000783 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214000784 FtsX-like permease family; Region: FtsX; pfam02687 330214000785 FtsX-like permease family; Region: FtsX; pfam02687 330214000786 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 330214000787 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 330214000788 Zn binding site [ion binding]; other site 330214000789 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 330214000790 tetramer (dimer of dimers) interface [polypeptide binding]; other site 330214000791 active site 330214000792 dimer interface [polypeptide binding]; other site 330214000793 glucokinase, proteobacterial type; Region: glk; TIGR00749 330214000794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 330214000795 nucleotide binding site [chemical binding]; other site 330214000796 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 330214000797 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 330214000798 putative active site [active] 330214000799 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 330214000800 active site 330214000801 dimer interface [polypeptide binding]; other site 330214000802 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 330214000803 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 330214000804 Ribonuclease P; Region: Ribonuclease_P; pfam00825 330214000805 membrane protein insertase; Provisional; Region: PRK01318 330214000806 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 330214000807 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 330214000808 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 330214000809 trmE is a tRNA modification GTPase; Region: trmE; cd04164 330214000810 G1 box; other site 330214000811 GTP/Mg2+ binding site [chemical binding]; other site 330214000812 Switch I region; other site 330214000813 G2 box; other site 330214000814 Switch II region; other site 330214000815 G3 box; other site 330214000816 G4 box; other site 330214000817 G5 box; other site 330214000818 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 330214000819 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 330214000820 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 330214000821 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 330214000822 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 330214000823 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 330214000824 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 330214000825 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 330214000826 P-loop; other site 330214000827 Magnesium ion binding site [ion binding]; other site 330214000828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 330214000829 Magnesium ion binding site [ion binding]; other site 330214000830 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 330214000831 ParB-like nuclease domain; Region: ParBc; pfam02195 330214000832 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 330214000833 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 330214000834 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 330214000835 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 330214000836 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 330214000837 Ligand Binding Site [chemical binding]; other site 330214000838 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 330214000839 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 330214000840 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 330214000841 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 330214000842 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 330214000843 beta subunit interaction interface [polypeptide binding]; other site 330214000844 Walker A motif; other site 330214000845 ATP binding site [chemical binding]; other site 330214000846 Walker B motif; other site 330214000847 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 330214000848 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 330214000849 core domain interface [polypeptide binding]; other site 330214000850 delta subunit interface [polypeptide binding]; other site 330214000851 epsilon subunit interface [polypeptide binding]; other site 330214000852 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 330214000853 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 330214000854 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 330214000855 alpha subunit interaction interface [polypeptide binding]; other site 330214000856 Walker A motif; other site 330214000857 ATP binding site [chemical binding]; other site 330214000858 Walker B motif; other site 330214000859 inhibitor binding site; inhibition site 330214000860 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 330214000861 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 330214000862 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 330214000863 gamma subunit interface [polypeptide binding]; other site 330214000864 epsilon subunit interface [polypeptide binding]; other site 330214000865 LBP interface [polypeptide binding]; other site 330214000866 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214000867 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 330214000868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214000869 RNA binding surface [nucleotide binding]; other site 330214000870 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 330214000871 active site 330214000872 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 330214000873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214000874 RNA binding surface [nucleotide binding]; other site 330214000875 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 330214000876 active site 330214000877 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 330214000878 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 330214000879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214000880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 330214000881 Coenzyme A binding pocket [chemical binding]; other site 330214000882 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 330214000883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 330214000884 ABC-ATPase subunit interface; other site 330214000885 dimer interface [polypeptide binding]; other site 330214000886 putative PBP binding regions; other site 330214000887 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 330214000888 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 330214000889 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 330214000890 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 330214000891 intersubunit interface [polypeptide binding]; other site 330214000892 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 330214000893 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 330214000894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214000895 binding surface 330214000896 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214000897 TPR motif; other site 330214000898 Right handed beta helix region; Region: Beta_helix; pfam13229 330214000899 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214000900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214000901 active site 330214000902 phosphorylation site [posttranslational modification] 330214000903 intermolecular recognition site; other site 330214000904 dimerization interface [polypeptide binding]; other site 330214000905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 330214000906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 330214000907 metal binding site [ion binding]; metal-binding site 330214000908 active site 330214000909 I-site; other site 330214000910 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 330214000911 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214000912 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214000913 catalytic residue [active] 330214000914 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 330214000915 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 330214000916 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 330214000917 putative active site [active] 330214000918 substrate binding site [chemical binding]; other site 330214000919 putative cosubstrate binding site; other site 330214000920 catalytic site [active] 330214000921 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 330214000922 substrate binding site [chemical binding]; other site 330214000923 NusB family; Region: NusB; pfam01029 330214000924 16S rRNA methyltransferase B; Provisional; Region: PRK14902 330214000925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214000926 S-adenosylmethionine binding site [chemical binding]; other site 330214000927 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 330214000928 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 330214000929 substrate binding site [chemical binding]; other site 330214000930 hexamer interface [polypeptide binding]; other site 330214000931 metal binding site [ion binding]; metal-binding site 330214000932 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 330214000933 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 330214000934 dimer interface [polypeptide binding]; other site 330214000935 motif 1; other site 330214000936 active site 330214000937 motif 2; other site 330214000938 motif 3; other site 330214000939 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 330214000940 tRNA synthetase B5 domain; Region: B5; pfam03484 330214000941 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 330214000942 dimer interface [polypeptide binding]; other site 330214000943 motif 1; other site 330214000944 motif 3; other site 330214000945 motif 2; other site 330214000946 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 330214000947 23S rRNA binding site [nucleotide binding]; other site 330214000948 L21 binding site [polypeptide binding]; other site 330214000949 L13 binding site [polypeptide binding]; other site 330214000950 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 330214000951 translation initiation factor IF-3; Region: infC; TIGR00168 330214000952 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 330214000953 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 330214000954 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 330214000955 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 330214000956 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 330214000957 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 330214000958 active site 330214000959 dimer interface [polypeptide binding]; other site 330214000960 motif 1; other site 330214000961 motif 2; other site 330214000962 motif 3; other site 330214000963 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 330214000964 anticodon binding site; other site 330214000965 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 330214000966 IHF dimer interface [polypeptide binding]; other site 330214000967 IHF - DNA interface [nucleotide binding]; other site 330214000968 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 330214000969 Transcriptional regulator; Region: Rrf2; pfam02082 330214000970 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 330214000971 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 330214000972 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 330214000973 HEPN domain; Region: HEPN; cl00824 330214000974 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 330214000975 CPxP motif; other site 330214000976 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 330214000977 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 330214000978 Active Sites [active] 330214000979 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 330214000980 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 330214000981 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 330214000982 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 330214000983 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 330214000984 Active Sites [active] 330214000985 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 330214000986 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 330214000987 G1 box; other site 330214000988 GTP/Mg2+ binding site [chemical binding]; other site 330214000989 G2 box; other site 330214000990 Switch I region; other site 330214000991 G3 box; other site 330214000992 Switch II region; other site 330214000993 G4 box; other site 330214000994 G5 box; other site 330214000995 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 330214000996 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 330214000997 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 330214000998 active site 330214000999 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 330214001000 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 330214001001 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001002 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001003 hypothetical protein; Validated; Region: PRK00110 330214001004 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 330214001005 RuvA N terminal domain; Region: RuvA_N; pfam01330 330214001006 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 330214001007 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 330214001008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214001009 Walker A motif; other site 330214001010 ATP binding site [chemical binding]; other site 330214001011 Walker B motif; other site 330214001012 arginine finger; other site 330214001013 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 330214001014 Chorismate mutase type II; Region: CM_2; pfam01817 330214001015 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 330214001016 Prephenate dehydratase; Region: PDT; pfam00800 330214001017 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 330214001018 putative L-Phe binding site [chemical binding]; other site 330214001019 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 330214001020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214001021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214001022 homodimer interface [polypeptide binding]; other site 330214001023 catalytic residue [active] 330214001024 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 330214001025 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 330214001026 prephenate dehydrogenase; Validated; Region: PRK08507 330214001027 Prephenate dehydrogenase; Region: PDH; pfam02153 330214001028 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 330214001029 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 330214001030 hinge; other site 330214001031 active site 330214001032 cytidylate kinase; Provisional; Region: cmk; PRK00023 330214001033 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 330214001034 CMP-binding site; other site 330214001035 The sites determining sugar specificity; other site 330214001036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 330214001037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 330214001038 putative acyl-acceptor binding pocket; other site 330214001039 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 330214001040 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 330214001041 RNA binding site [nucleotide binding]; other site 330214001042 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 330214001043 RNA binding site [nucleotide binding]; other site 330214001044 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 330214001045 RNA binding site [nucleotide binding]; other site 330214001046 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 330214001047 RNA binding site [nucleotide binding]; other site 330214001048 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 330214001049 RNA binding site [nucleotide binding]; other site 330214001050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 330214001051 RNA binding site [nucleotide binding]; other site 330214001052 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 330214001053 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 330214001054 tandem repeat interface [polypeptide binding]; other site 330214001055 oligomer interface [polypeptide binding]; other site 330214001056 active site residues [active] 330214001057 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 330214001058 IHF dimer interface [polypeptide binding]; other site 330214001059 IHF - DNA interface [nucleotide binding]; other site 330214001060 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001061 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001062 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001063 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 330214001064 Family description; Region: VCBS; pfam13517 330214001065 Family description; Region: VCBS; pfam13517 330214001066 Family description; Region: VCBS; pfam13517 330214001067 Family description; Region: VCBS; pfam13517 330214001068 Family description; Region: VCBS; pfam13517 330214001069 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 330214001070 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 330214001071 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 330214001072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 330214001073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 330214001074 dimerization interface [polypeptide binding]; other site 330214001075 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 330214001076 apolar tunnel; other site 330214001077 heme binding site [chemical binding]; other site 330214001078 dimerization interface [polypeptide binding]; other site 330214001079 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 330214001080 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 330214001081 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 330214001082 NAD(P) binding site [chemical binding]; other site 330214001083 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 330214001084 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 330214001085 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214001086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214001087 protein binding site [polypeptide binding]; other site 330214001088 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 330214001089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214001090 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 330214001091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214001092 DNA binding residues [nucleotide binding] 330214001093 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 330214001094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214001095 S-adenosylmethionine binding site [chemical binding]; other site 330214001096 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 330214001097 classical (c) SDRs; Region: SDR_c; cd05233 330214001098 NAD(P) binding site [chemical binding]; other site 330214001099 active site 330214001100 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 330214001101 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 330214001102 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 330214001103 shikimate binding site; other site 330214001104 NAD(P) binding site [chemical binding]; other site 330214001105 shikimate kinase; Reviewed; Region: aroK; PRK00131 330214001106 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 330214001107 ADP binding site [chemical binding]; other site 330214001108 magnesium binding site [ion binding]; other site 330214001109 putative shikimate binding site; other site 330214001110 RelB antitoxin; Region: RelB; cl01171 330214001111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 330214001112 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 330214001113 RelB antitoxin; Region: RelB; cl01171 330214001114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 330214001115 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214001116 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214001117 ligand binding site [chemical binding]; other site 330214001118 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 330214001119 PilZ domain; Region: PilZ; pfam07238 330214001120 PilZ domain; Region: PilZ; cl01260 330214001121 TolA protein; Region: tolA_full; TIGR02794 330214001122 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 330214001123 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 330214001124 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 330214001125 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 330214001126 methionine sulfoxide reductase A; Provisional; Region: PRK14054 330214001127 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 330214001128 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 330214001129 Ligand Binding Site [chemical binding]; other site 330214001130 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 330214001131 Low molecular weight phosphatase family; Region: LMWPc; cl00105 330214001132 active site 330214001133 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 330214001134 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 330214001135 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 330214001136 ATP-grasp domain; Region: ATP-grasp_4; cl17255 330214001137 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 330214001138 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 330214001139 catalytic core [active] 330214001140 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 330214001141 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 330214001142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 330214001143 acetylornithine aminotransferase; Provisional; Region: PRK02627 330214001144 inhibitor-cofactor binding pocket; inhibition site 330214001145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214001146 catalytic residue [active] 330214001147 ornithine carbamoyltransferase; Provisional; Region: PRK00779 330214001148 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 330214001149 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 330214001150 argininosuccinate synthase; Provisional; Region: PRK13820 330214001151 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 330214001152 ANP binding site [chemical binding]; other site 330214001153 Substrate Binding Site II [chemical binding]; other site 330214001154 Substrate Binding Site I [chemical binding]; other site 330214001155 argininosuccinate lyase; Provisional; Region: PRK00855 330214001156 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 330214001157 active sites [active] 330214001158 tetramer interface [polypeptide binding]; other site 330214001159 diaminopimelate decarboxylase; Region: lysA; TIGR01048 330214001160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 330214001161 active site 330214001162 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 330214001163 substrate binding site [chemical binding]; other site 330214001164 catalytic residues [active] 330214001165 dimer interface [polypeptide binding]; other site 330214001166 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 330214001167 dihydrodipicolinate synthase; Region: dapA; TIGR00674 330214001168 dimer interface [polypeptide binding]; other site 330214001169 active site 330214001170 catalytic residue [active] 330214001171 dihydrodipicolinate reductase; Provisional; Region: PRK00048 330214001172 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 330214001173 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 330214001174 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 330214001175 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 330214001176 active site 330214001177 intersubunit interactions; other site 330214001178 catalytic residue [active] 330214001179 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 330214001180 Fe-S cluster binding site [ion binding]; other site 330214001181 DNA binding site [nucleotide binding] 330214001182 active site 330214001183 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214001184 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214001185 catalytic residue [active] 330214001186 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 330214001187 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 330214001188 MOFRL family; Region: MOFRL; pfam05161 330214001189 phosphoenolpyruvate synthase; Validated; Region: PRK06241 330214001190 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 330214001191 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 330214001192 RmuC family; Region: RmuC; pfam02646 330214001193 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544 330214001194 homodimer interface [polypeptide binding]; other site 330214001195 active site 330214001196 metal binding site [ion binding]; metal-binding site 330214001197 PilZ domain; Region: PilZ; pfam07238 330214001198 pantoate--beta-alanine ligase; Region: panC; TIGR00018 330214001199 Pantoate-beta-alanine ligase; Region: PanC; cd00560 330214001200 active site 330214001201 ATP-binding site [chemical binding]; other site 330214001202 pantoate-binding site; other site 330214001203 HXXH motif; other site 330214001204 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 330214001205 catalytic center binding site [active] 330214001206 ATP binding site [chemical binding]; other site 330214001207 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 330214001208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214001209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214001210 homodimer interface [polypeptide binding]; other site 330214001211 catalytic residue [active] 330214001212 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 330214001213 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 330214001214 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 330214001215 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 330214001216 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 330214001217 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 330214001218 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 330214001219 Walker A/P-loop; other site 330214001220 ATP binding site [chemical binding]; other site 330214001221 Q-loop/lid; other site 330214001222 ABC transporter signature motif; other site 330214001223 Walker B; other site 330214001224 D-loop; other site 330214001225 H-loop/switch region; other site 330214001226 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 330214001227 putative carbohydrate binding site [chemical binding]; other site 330214001228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214001229 S-adenosylmethionine binding site [chemical binding]; other site 330214001230 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 330214001231 catalytic core [active] 330214001232 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 330214001233 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 330214001234 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 330214001235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214001236 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 330214001237 Walker A/P-loop; other site 330214001238 ATP binding site [chemical binding]; other site 330214001239 Q-loop/lid; other site 330214001240 ABC transporter signature motif; other site 330214001241 Walker B; other site 330214001242 D-loop; other site 330214001243 H-loop/switch region; other site 330214001244 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 330214001245 ABC-2 type transporter; Region: ABC2_membrane; cl17235 330214001246 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 330214001247 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 330214001248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 330214001249 MarR family; Region: MarR_2; pfam12802 330214001250 phosphodiesterase YaeI; Provisional; Region: PRK11340 330214001251 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 330214001252 putative active site [active] 330214001253 putative metal binding site [ion binding]; other site 330214001254 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 330214001255 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 330214001256 Permutation of conserved domain; other site 330214001257 active site 330214001258 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 330214001259 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 330214001260 Uncharacterized conserved protein [Function unknown]; Region: COG1915 330214001261 homodimer interface [polypeptide binding]; other site 330214001262 Deoxyhypusine synthase; Region: DS; cl00826 330214001263 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 330214001264 Amidinotransferase; Region: Amidinotransf; pfam02274 330214001265 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 330214001266 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 330214001267 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 330214001268 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 330214001269 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 330214001270 AIR carboxylase; Region: AIRC; smart01001 330214001271 hypothetical protein; Provisional; Region: PRK04194 330214001272 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 330214001273 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 330214001274 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 330214001275 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 330214001276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214001277 S-adenosylmethionine binding site [chemical binding]; other site 330214001278 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 330214001279 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 330214001280 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 330214001281 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 330214001282 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 330214001283 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 330214001284 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 330214001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001286 Response regulator receiver domain; Region: Response_reg; pfam00072 330214001287 active site 330214001288 phosphorylation site [posttranslational modification] 330214001289 intermolecular recognition site; other site 330214001290 dimerization interface [polypeptide binding]; other site 330214001291 PAS domain S-box; Region: sensory_box; TIGR00229 330214001292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001293 putative active site [active] 330214001294 heme pocket [chemical binding]; other site 330214001295 PAS domain S-box; Region: sensory_box; TIGR00229 330214001296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001297 putative active site [active] 330214001298 heme pocket [chemical binding]; other site 330214001299 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214001300 GAF domain; Region: GAF; pfam01590 330214001301 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214001302 PAS domain; Region: PAS; smart00091 330214001303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001304 dimer interface [polypeptide binding]; other site 330214001305 phosphorylation site [posttranslational modification] 330214001306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001307 ATP binding site [chemical binding]; other site 330214001308 Mg2+ binding site [ion binding]; other site 330214001309 G-X-G motif; other site 330214001310 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 330214001311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214001312 dimerization interface [polypeptide binding]; other site 330214001313 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214001314 GAF domain; Region: GAF; pfam01590 330214001315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214001316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001317 dimer interface [polypeptide binding]; other site 330214001318 phosphorylation site [posttranslational modification] 330214001319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001320 ATP binding site [chemical binding]; other site 330214001321 Mg2+ binding site [ion binding]; other site 330214001322 G-X-G motif; other site 330214001323 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 330214001324 Response regulator receiver domain; Region: Response_reg; pfam00072 330214001325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001326 active site 330214001327 phosphorylation site [posttranslational modification] 330214001328 intermolecular recognition site; other site 330214001329 dimerization interface [polypeptide binding]; other site 330214001330 PAS domain S-box; Region: sensory_box; TIGR00229 330214001331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001332 putative active site [active] 330214001333 heme pocket [chemical binding]; other site 330214001334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001335 PAS domain; Region: PAS_9; pfam13426 330214001336 putative active site [active] 330214001337 heme pocket [chemical binding]; other site 330214001338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001339 PAS fold; Region: PAS_3; pfam08447 330214001340 putative active site [active] 330214001341 heme pocket [chemical binding]; other site 330214001342 PAS domain S-box; Region: sensory_box; TIGR00229 330214001343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001344 putative active site [active] 330214001345 heme pocket [chemical binding]; other site 330214001346 PAS fold; Region: PAS_4; pfam08448 330214001347 PAS fold; Region: PAS_3; pfam08447 330214001348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001349 putative active site [active] 330214001350 heme pocket [chemical binding]; other site 330214001351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001352 PAS fold; Region: PAS_3; pfam08447 330214001353 putative active site [active] 330214001354 heme pocket [chemical binding]; other site 330214001355 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 330214001356 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001357 N-terminal plug; other site 330214001358 ligand-binding site [chemical binding]; other site 330214001359 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 330214001360 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001361 N-terminal plug; other site 330214001362 ligand-binding site [chemical binding]; other site 330214001363 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 330214001364 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 330214001365 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 330214001366 CHAT domain; Region: CHAT; cl17868 330214001367 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 330214001368 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 330214001369 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214001370 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 330214001371 haemagglutination activity domain; Region: Haemagg_act; pfam05860 330214001372 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 330214001373 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214001374 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214001375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214001376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001377 dimer interface [polypeptide binding]; other site 330214001378 phosphorylation site [posttranslational modification] 330214001379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001380 ATP binding site [chemical binding]; other site 330214001381 Mg2+ binding site [ion binding]; other site 330214001382 G-X-G motif; other site 330214001383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001384 Response regulator receiver domain; Region: Response_reg; pfam00072 330214001385 active site 330214001386 phosphorylation site [posttranslational modification] 330214001387 intermolecular recognition site; other site 330214001388 dimerization interface [polypeptide binding]; other site 330214001389 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 330214001390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214001391 FeS/SAM binding site; other site 330214001392 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 330214001393 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001394 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214001395 Ligand Binding Site [chemical binding]; other site 330214001396 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214001397 Ligand Binding Site [chemical binding]; other site 330214001398 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001399 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 330214001400 iron binding site [ion binding]; other site 330214001401 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001402 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214001403 B12 binding domain; Region: B12-binding; pfam02310 330214001404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214001405 Radical SAM superfamily; Region: Radical_SAM; pfam04055 330214001406 FeS/SAM binding site; other site 330214001407 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 330214001408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214001409 S-adenosylmethionine binding site [chemical binding]; other site 330214001410 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 330214001411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 330214001412 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 330214001413 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 330214001414 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 330214001415 AAA domain; Region: AAA_21; pfam13304 330214001416 Protein of unknown function, DUF486; Region: DUF486; cl01236 330214001417 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 330214001418 Domain of unknown function DUF87; Region: DUF87; pfam01935 330214001419 AAA-like domain; Region: AAA_10; pfam12846 330214001420 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214001421 GAF domain; Region: GAF; pfam01590 330214001422 PAS fold; Region: PAS; pfam00989 330214001423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001424 putative active site [active] 330214001425 heme pocket [chemical binding]; other site 330214001426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001427 PAS fold; Region: PAS_3; pfam08447 330214001428 putative active site [active] 330214001429 heme pocket [chemical binding]; other site 330214001430 PAS domain S-box; Region: sensory_box; TIGR00229 330214001431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001432 putative active site [active] 330214001433 heme pocket [chemical binding]; other site 330214001434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001435 PAS fold; Region: PAS_3; pfam08447 330214001436 putative active site [active] 330214001437 heme pocket [chemical binding]; other site 330214001438 PAS domain S-box; Region: sensory_box; TIGR00229 330214001439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001440 putative active site [active] 330214001441 heme pocket [chemical binding]; other site 330214001442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001443 PAS fold; Region: PAS_3; pfam08447 330214001444 putative active site [active] 330214001445 heme pocket [chemical binding]; other site 330214001446 Histidine kinase; Region: HisKA_3; pfam07730 330214001447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001448 ATP binding site [chemical binding]; other site 330214001449 Mg2+ binding site [ion binding]; other site 330214001450 G-X-G motif; other site 330214001451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214001452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001453 active site 330214001454 phosphorylation site [posttranslational modification] 330214001455 intermolecular recognition site; other site 330214001456 dimerization interface [polypeptide binding]; other site 330214001457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214001458 DNA binding residues [nucleotide binding] 330214001459 dimerization interface [polypeptide binding]; other site 330214001460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214001461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001462 active site 330214001463 phosphorylation site [posttranslational modification] 330214001464 intermolecular recognition site; other site 330214001465 dimerization interface [polypeptide binding]; other site 330214001466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214001467 DNA binding residues [nucleotide binding] 330214001468 dimerization interface [polypeptide binding]; other site 330214001469 Response regulator receiver domain; Region: Response_reg; pfam00072 330214001470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001471 active site 330214001472 phosphorylation site [posttranslational modification] 330214001473 intermolecular recognition site; other site 330214001474 dimerization interface [polypeptide binding]; other site 330214001475 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 330214001476 active site 330214001477 nucleophile elbow; other site 330214001478 hypothetical protein; Provisional; Region: PRK05208 330214001479 PAS domain S-box; Region: sensory_box; TIGR00229 330214001480 PAS domain S-box; Region: sensory_box; TIGR00229 330214001481 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001482 putative active site [active] 330214001483 heme pocket [chemical binding]; other site 330214001484 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214001485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001486 putative active site [active] 330214001487 heme pocket [chemical binding]; other site 330214001488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001489 dimer interface [polypeptide binding]; other site 330214001490 phosphorylation site [posttranslational modification] 330214001491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001492 ATP binding site [chemical binding]; other site 330214001493 Mg2+ binding site [ion binding]; other site 330214001494 G-X-G motif; other site 330214001495 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214001496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001497 active site 330214001498 phosphorylation site [posttranslational modification] 330214001499 intermolecular recognition site; other site 330214001500 dimerization interface [polypeptide binding]; other site 330214001501 Response regulator receiver domain; Region: Response_reg; pfam00072 330214001502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001503 active site 330214001504 phosphorylation site [posttranslational modification] 330214001505 intermolecular recognition site; other site 330214001506 dimerization interface [polypeptide binding]; other site 330214001507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001508 PAS fold; Region: PAS_3; pfam08447 330214001509 putative active site [active] 330214001510 heme pocket [chemical binding]; other site 330214001511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001512 PAS fold; Region: PAS_3; pfam08447 330214001513 putative active site [active] 330214001514 heme pocket [chemical binding]; other site 330214001515 PAS domain S-box; Region: sensory_box; TIGR00229 330214001516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001517 putative active site [active] 330214001518 heme pocket [chemical binding]; other site 330214001519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001520 PAS fold; Region: PAS_3; pfam08447 330214001521 putative active site [active] 330214001522 heme pocket [chemical binding]; other site 330214001523 PAS domain S-box; Region: sensory_box; TIGR00229 330214001524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001525 putative active site [active] 330214001526 heme pocket [chemical binding]; other site 330214001527 PAS fold; Region: PAS; pfam00989 330214001528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001529 putative active site [active] 330214001530 heme pocket [chemical binding]; other site 330214001531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001532 dimer interface [polypeptide binding]; other site 330214001533 phosphorylation site [posttranslational modification] 330214001534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001535 ATP binding site [chemical binding]; other site 330214001536 Mg2+ binding site [ion binding]; other site 330214001537 G-X-G motif; other site 330214001538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001539 active site 330214001540 phosphorylation site [posttranslational modification] 330214001541 intermolecular recognition site; other site 330214001542 dimerization interface [polypeptide binding]; other site 330214001543 Response regulator receiver domain; Region: Response_reg; pfam00072 330214001544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001545 active site 330214001546 phosphorylation site [posttranslational modification] 330214001547 intermolecular recognition site; other site 330214001548 dimerization interface [polypeptide binding]; other site 330214001549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214001550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001551 active site 330214001552 phosphorylation site [posttranslational modification] 330214001553 intermolecular recognition site; other site 330214001554 dimerization interface [polypeptide binding]; other site 330214001555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214001556 DNA binding residues [nucleotide binding] 330214001557 dimerization interface [polypeptide binding]; other site 330214001558 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 330214001559 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 330214001560 dimer interface [polypeptide binding]; other site 330214001561 active site 330214001562 transcriptional regulator EpsA; Region: EpsA; TIGR03020 330214001563 Autoinducer binding domain; Region: Autoind_bind; pfam03472 330214001564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214001565 DNA binding residues [nucleotide binding] 330214001566 dimerization interface [polypeptide binding]; other site 330214001567 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 330214001568 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 330214001569 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 330214001570 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 330214001571 GIY-YIG motif/motif A; other site 330214001572 active site 330214001573 catalytic site [active] 330214001574 putative DNA binding site [nucleotide binding]; other site 330214001575 metal binding site [ion binding]; metal-binding site 330214001576 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 330214001577 diaminopimelate epimerase; Provisional; Region: PRK13577 330214001578 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 330214001579 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 330214001580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214001581 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 330214001582 active site 330214001583 metal binding site [ion binding]; metal-binding site 330214001584 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 330214001585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214001586 Coenzyme A binding pocket [chemical binding]; other site 330214001587 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 330214001588 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 330214001589 NodB motif; other site 330214001590 putative active site [active] 330214001591 putative catalytic site [active] 330214001592 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 330214001593 Peptidase family M50; Region: Peptidase_M50; pfam02163 330214001594 active site 330214001595 putative substrate binding region [chemical binding]; other site 330214001596 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214001597 FOG: CBS domain [General function prediction only]; Region: COG0517 330214001598 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214001599 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 330214001600 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 330214001601 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214001602 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 330214001603 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214001604 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 330214001605 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 330214001606 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214001607 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 330214001608 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 330214001609 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 330214001610 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 330214001611 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 330214001612 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 330214001613 4Fe-4S binding domain; Region: Fer4; pfam00037 330214001614 4Fe-4S binding domain; Region: Fer4; pfam00037 330214001615 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 330214001616 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 330214001617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 330214001618 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 330214001619 catalytic loop [active] 330214001620 iron binding site [ion binding]; other site 330214001621 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 330214001622 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214001623 molybdopterin cofactor binding site; other site 330214001624 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 330214001625 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 330214001626 SLBB domain; Region: SLBB; pfam10531 330214001627 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 330214001628 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 330214001629 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 330214001630 putative dimer interface [polypeptide binding]; other site 330214001631 [2Fe-2S] cluster binding site [ion binding]; other site 330214001632 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 330214001633 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 330214001634 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 330214001635 NADH dehydrogenase subunit D; Validated; Region: PRK06075 330214001636 NADH dehydrogenase subunit B; Validated; Region: PRK06411 330214001637 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 330214001638 Uncharacterized conserved protein [Function unknown]; Region: COG1565 330214001639 Sensors of blue-light using FAD; Region: BLUF; pfam04940 330214001640 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 330214001641 Helix-turn-helix domain; Region: HTH_38; pfam13936 330214001642 Integrase core domain; Region: rve; pfam00665 330214001643 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 330214001644 active site 330214001645 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 330214001646 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 330214001647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 330214001648 nucleotide binding region [chemical binding]; other site 330214001649 ATP-binding site [chemical binding]; other site 330214001650 SEC-C motif; Region: SEC-C; pfam02810 330214001651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214001652 binding surface 330214001653 TPR motif; other site 330214001654 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 330214001655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214001656 binding surface 330214001657 TPR motif; other site 330214001658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214001659 binding surface 330214001660 TPR motif; other site 330214001661 BNR repeat-like domain; Region: BNR_2; pfam13088 330214001662 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 330214001663 Asp-box motif; other site 330214001664 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 330214001665 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 330214001666 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 330214001667 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214001668 catalytic residues [active] 330214001669 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 330214001670 BNR repeat-like domain; Region: BNR_2; pfam13088 330214001671 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 330214001672 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214001673 catalytic residues [active] 330214001674 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 330214001675 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001676 N-terminal plug; other site 330214001677 ligand-binding site [chemical binding]; other site 330214001678 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214001679 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 330214001680 active site 330214001681 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 330214001682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001683 N-terminal plug; other site 330214001684 ligand-binding site [chemical binding]; other site 330214001685 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 330214001686 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 330214001687 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 330214001688 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001689 N-terminal plug; other site 330214001690 ligand-binding site [chemical binding]; other site 330214001691 EamA-like transporter family; Region: EamA; pfam00892 330214001692 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 330214001693 EamA-like transporter family; Region: EamA; pfam00892 330214001694 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 330214001695 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001696 N-terminal plug; other site 330214001697 ligand-binding site [chemical binding]; other site 330214001698 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 330214001699 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 330214001700 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 330214001701 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 330214001702 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 330214001703 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 330214001704 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001705 N-terminal plug; other site 330214001706 ligand-binding site [chemical binding]; other site 330214001707 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 330214001708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001709 N-terminal plug; other site 330214001710 ligand-binding site [chemical binding]; other site 330214001711 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 330214001712 oligomeric interface; other site 330214001713 putative active site [active] 330214001714 homodimer interface [polypeptide binding]; other site 330214001715 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 330214001716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001717 N-terminal plug; other site 330214001718 ligand-binding site [chemical binding]; other site 330214001719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214001720 Walker A motif; other site 330214001721 ATP binding site [chemical binding]; other site 330214001722 Walker B motif; other site 330214001723 arginine finger; other site 330214001724 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 330214001725 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 330214001726 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 330214001727 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 330214001728 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214001729 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214001730 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 330214001731 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 330214001732 Walker A/P-loop; other site 330214001733 ATP binding site [chemical binding]; other site 330214001734 Q-loop/lid; other site 330214001735 ABC transporter signature motif; other site 330214001736 Walker B; other site 330214001737 D-loop; other site 330214001738 H-loop/switch region; other site 330214001739 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214001740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214001741 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 330214001742 FtsX-like permease family; Region: FtsX; pfam02687 330214001743 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214001744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214001745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214001746 binding surface 330214001747 TPR motif; other site 330214001748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214001749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214001750 binding surface 330214001751 TPR motif; other site 330214001752 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214001753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214001754 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 330214001755 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214001756 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 330214001757 Uncharacterized conserved protein [Function unknown]; Region: COG3350 330214001758 Uncharacterized conserved protein [Function unknown]; Region: COG3350 330214001759 YHS domain; Region: YHS; pfam04945 330214001760 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 330214001761 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 330214001762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214001763 motif II; other site 330214001764 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 330214001765 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214001766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214001767 protein binding site [polypeptide binding]; other site 330214001768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214001769 protein binding site [polypeptide binding]; other site 330214001770 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 330214001771 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 330214001772 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 330214001773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214001774 dimerization interface [polypeptide binding]; other site 330214001775 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214001776 GAF domain; Region: GAF_3; pfam13492 330214001777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001778 dimer interface [polypeptide binding]; other site 330214001779 phosphorylation site [posttranslational modification] 330214001780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001781 ATP binding site [chemical binding]; other site 330214001782 Mg2+ binding site [ion binding]; other site 330214001783 G-X-G motif; other site 330214001784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001785 active site 330214001786 phosphorylation site [posttranslational modification] 330214001787 intermolecular recognition site; other site 330214001788 dimerization interface [polypeptide binding]; other site 330214001789 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 330214001790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001791 active site 330214001792 phosphorylation site [posttranslational modification] 330214001793 intermolecular recognition site; other site 330214001794 dimerization interface [polypeptide binding]; other site 330214001795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214001796 Zn2+ binding site [ion binding]; other site 330214001797 Mg2+ binding site [ion binding]; other site 330214001798 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 330214001799 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 330214001800 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 330214001801 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 330214001802 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 330214001803 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214001804 N-terminal plug; other site 330214001805 ligand-binding site [chemical binding]; other site 330214001806 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 330214001807 active site 330214001808 DNA binding site [nucleotide binding] 330214001809 GAF domain; Region: GAF_3; pfam13492 330214001810 GAF domain; Region: GAF_2; pfam13185 330214001811 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214001812 GAF domain; Region: GAF_2; pfam13185 330214001813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001814 dimer interface [polypeptide binding]; other site 330214001815 phosphorylation site [posttranslational modification] 330214001816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001817 ATP binding site [chemical binding]; other site 330214001818 Mg2+ binding site [ion binding]; other site 330214001819 G-X-G motif; other site 330214001820 Membrane protein of unknown function; Region: DUF360; pfam04020 330214001821 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 330214001822 RNA binding site [nucleotide binding]; other site 330214001823 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214001824 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214001825 Protein of unknown function (DUF422); Region: DUF422; cl00991 330214001826 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 330214001827 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 330214001828 putative NADP binding site [chemical binding]; other site 330214001829 putative substrate binding site [chemical binding]; other site 330214001830 active site 330214001831 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 330214001832 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 330214001833 substrate binding pocket [chemical binding]; other site 330214001834 chain length determination region; other site 330214001835 substrate-Mg2+ binding site; other site 330214001836 catalytic residues [active] 330214001837 aspartate-rich region 1; other site 330214001838 active site lid residues [active] 330214001839 aspartate-rich region 2; other site 330214001840 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 330214001841 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 330214001842 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 330214001843 Sel1-like repeats; Region: SEL1; smart00671 330214001844 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 330214001845 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 330214001846 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 330214001847 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 330214001848 active site 330214001849 putative substrate binding region [chemical binding]; other site 330214001850 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 330214001851 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 330214001852 FAD binding pocket [chemical binding]; other site 330214001853 conserved FAD binding motif [chemical binding]; other site 330214001854 phosphate binding motif [ion binding]; other site 330214001855 beta-alpha-beta structure motif; other site 330214001856 NAD binding pocket [chemical binding]; other site 330214001857 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 330214001858 SCP-2 sterol transfer family; Region: SCP2; pfam02036 330214001859 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 330214001860 Protein export membrane protein; Region: SecD_SecF; cl14618 330214001861 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214001862 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214001863 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214001864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 330214001865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 330214001866 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 330214001867 PYR/PP interface [polypeptide binding]; other site 330214001868 dimer interface [polypeptide binding]; other site 330214001869 TPP binding site [chemical binding]; other site 330214001870 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 330214001871 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 330214001872 TPP-binding site [chemical binding]; other site 330214001873 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 330214001874 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 330214001875 catalytic residue [active] 330214001876 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 330214001877 active site 330214001878 metal-binding site 330214001879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214001880 active site 330214001881 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 330214001882 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 330214001883 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 330214001884 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 330214001885 Ligand binding site; other site 330214001886 Putative Catalytic site; other site 330214001887 DXD motif; other site 330214001888 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214001889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214001890 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214001891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214001892 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 330214001893 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 330214001894 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 330214001895 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214001896 active site 330214001897 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 330214001898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 330214001899 PilZ domain; Region: PilZ; pfam07238 330214001900 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 330214001901 Carbon starvation protein CstA; Region: CstA; pfam02554 330214001902 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 330214001903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 330214001904 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 330214001905 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 330214001906 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 330214001907 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 330214001908 Dimer interface [polypeptide binding]; other site 330214001909 anticodon binding site; other site 330214001910 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 330214001911 homodimer interface [polypeptide binding]; other site 330214001912 motif 1; other site 330214001913 motif 2; other site 330214001914 active site 330214001915 motif 3; other site 330214001916 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 330214001917 MraW methylase family; Region: Methyltransf_5; cl17771 330214001918 Cell division protein FtsL; Region: FtsL; cl11433 330214001919 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 330214001920 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 330214001921 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 330214001922 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 330214001923 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 330214001924 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 330214001925 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 330214001926 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 330214001927 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 330214001928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 330214001929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 330214001930 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 330214001931 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 330214001932 Mg++ binding site [ion binding]; other site 330214001933 putative catalytic motif [active] 330214001934 putative substrate binding site [chemical binding]; other site 330214001935 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 330214001936 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 330214001937 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 330214001938 cell division protein FtsW; Region: ftsW; TIGR02614 330214001939 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 330214001940 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 330214001941 active site 330214001942 homodimer interface [polypeptide binding]; other site 330214001943 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 330214001944 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 330214001945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 330214001946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 330214001947 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 330214001948 FAD binding domain; Region: FAD_binding_4; pfam01565 330214001949 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 330214001950 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 330214001951 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 330214001952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 330214001953 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 330214001954 cell division protein FtsA; Region: ftsA; TIGR01174 330214001955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 330214001956 nucleotide binding site [chemical binding]; other site 330214001957 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 330214001958 Cell division protein FtsA; Region: FtsA; pfam14450 330214001959 cell division protein FtsZ; Validated; Region: PRK09330 330214001960 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 330214001961 nucleotide binding site [chemical binding]; other site 330214001962 SulA interaction site; other site 330214001963 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 330214001964 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 330214001965 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 330214001966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 330214001967 catalytic residue [active] 330214001968 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 330214001969 pyrroline-5-carboxylate reductase; Region: PLN02688 330214001970 YGGT family; Region: YGGT; pfam02325 330214001971 DivIVA protein; Region: DivIVA; pfam05103 330214001972 DivIVA domain; Region: DivI1A_domain; TIGR03544 330214001973 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 330214001974 Beta-lactamase; Region: Beta-lactamase; cl17358 330214001975 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 330214001976 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 330214001977 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 330214001978 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 330214001979 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214001980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214001981 putative active site [active] 330214001982 heme pocket [chemical binding]; other site 330214001983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214001984 dimer interface [polypeptide binding]; other site 330214001985 phosphorylation site [posttranslational modification] 330214001986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214001987 ATP binding site [chemical binding]; other site 330214001988 Mg2+ binding site [ion binding]; other site 330214001989 G-X-G motif; other site 330214001990 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214001992 active site 330214001993 phosphorylation site [posttranslational modification] 330214001994 intermolecular recognition site; other site 330214001995 dimerization interface [polypeptide binding]; other site 330214001996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214001997 Walker A motif; other site 330214001998 ATP binding site [chemical binding]; other site 330214001999 Walker B motif; other site 330214002000 arginine finger; other site 330214002001 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214002002 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 330214002003 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 330214002004 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 330214002005 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 330214002006 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 330214002007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214002008 active site 330214002009 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 330214002010 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 330214002011 5S rRNA interface [nucleotide binding]; other site 330214002012 CTC domain interface [polypeptide binding]; other site 330214002013 L16 interface [polypeptide binding]; other site 330214002014 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 330214002015 putative active site [active] 330214002016 catalytic residue [active] 330214002017 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 330214002018 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 330214002019 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 330214002020 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 330214002021 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 330214002022 dimer interface [polypeptide binding]; other site 330214002023 ssDNA binding site [nucleotide binding]; other site 330214002024 tetramer (dimer of dimers) interface [polypeptide binding]; other site 330214002025 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 330214002026 putative phosphate acyltransferase; Provisional; Region: PRK05331 330214002027 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 330214002028 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 330214002029 dimer interface [polypeptide binding]; other site 330214002030 active site 330214002031 CoA binding pocket [chemical binding]; other site 330214002032 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 330214002033 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 330214002034 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 330214002035 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 330214002036 NAD(P) binding site [chemical binding]; other site 330214002037 homotetramer interface [polypeptide binding]; other site 330214002038 homodimer interface [polypeptide binding]; other site 330214002039 active site 330214002040 acyl carrier protein; Provisional; Region: acpP; PRK00982 330214002041 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 330214002042 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 330214002043 dimer interface [polypeptide binding]; other site 330214002044 active site 330214002045 ribonuclease III; Reviewed; Region: rnc; PRK00102 330214002046 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 330214002047 dimerization interface [polypeptide binding]; other site 330214002048 active site 330214002049 metal binding site [ion binding]; metal-binding site 330214002050 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 330214002051 dsRNA binding site [nucleotide binding]; other site 330214002052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 330214002053 active site 330214002054 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 330214002055 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 330214002056 putative active site [active] 330214002057 putative catalytic site [active] 330214002058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002059 Response regulator receiver domain; Region: Response_reg; pfam00072 330214002060 active site 330214002061 phosphorylation site [posttranslational modification] 330214002062 intermolecular recognition site; other site 330214002063 dimerization interface [polypeptide binding]; other site 330214002064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002065 dimer interface [polypeptide binding]; other site 330214002066 phosphorylation site [posttranslational modification] 330214002067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002068 ATP binding site [chemical binding]; other site 330214002069 Mg2+ binding site [ion binding]; other site 330214002070 G-X-G motif; other site 330214002071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002072 PAS domain; Region: PAS_9; pfam13426 330214002073 putative active site [active] 330214002074 heme pocket [chemical binding]; other site 330214002075 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214002076 GAF domain; Region: GAF; pfam01590 330214002077 PAS domain S-box; Region: sensory_box; TIGR00229 330214002078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002079 putative active site [active] 330214002080 heme pocket [chemical binding]; other site 330214002081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002082 PAS fold; Region: PAS_3; pfam08447 330214002083 putative active site [active] 330214002084 heme pocket [chemical binding]; other site 330214002085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214002086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002087 dimer interface [polypeptide binding]; other site 330214002088 phosphorylation site [posttranslational modification] 330214002089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002090 ATP binding site [chemical binding]; other site 330214002091 Mg2+ binding site [ion binding]; other site 330214002092 G-X-G motif; other site 330214002093 Response regulator receiver domain; Region: Response_reg; pfam00072 330214002094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002095 active site 330214002096 phosphorylation site [posttranslational modification] 330214002097 intermolecular recognition site; other site 330214002098 dimerization interface [polypeptide binding]; other site 330214002099 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214002100 putative binding surface; other site 330214002101 active site 330214002102 FIST N domain; Region: FIST; pfam08495 330214002103 Uncharacterized conserved protein [Function unknown]; Region: COG3287 330214002104 FIST C domain; Region: FIST_C; pfam10442 330214002105 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214002106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002107 putative active site [active] 330214002108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002109 dimer interface [polypeptide binding]; other site 330214002110 phosphorylation site [posttranslational modification] 330214002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002112 ATP binding site [chemical binding]; other site 330214002113 Mg2+ binding site [ion binding]; other site 330214002114 G-X-G motif; other site 330214002115 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 330214002116 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 330214002117 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 330214002118 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 330214002119 homodimer interface [polypeptide binding]; other site 330214002120 NADP binding site [chemical binding]; other site 330214002121 substrate binding site [chemical binding]; other site 330214002122 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 330214002123 FAD binding site [chemical binding]; other site 330214002124 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 330214002125 oligomerization interface [polypeptide binding]; other site 330214002126 active site 330214002127 metal binding site [ion binding]; metal-binding site 330214002128 Domain of unknown function (DUF309); Region: DUF309; pfam03745 330214002129 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 330214002130 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 330214002131 active site 330214002132 metal binding site [ion binding]; metal-binding site 330214002133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002134 PAS domain; Region: PAS_9; pfam13426 330214002135 putative active site [active] 330214002136 heme pocket [chemical binding]; other site 330214002137 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214002138 GAF domain; Region: GAF; pfam01590 330214002139 PAS fold; Region: PAS_4; pfam08448 330214002140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002141 putative active site [active] 330214002142 heme pocket [chemical binding]; other site 330214002143 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214002144 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214002145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002146 putative active site [active] 330214002147 heme pocket [chemical binding]; other site 330214002148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002149 dimer interface [polypeptide binding]; other site 330214002150 phosphorylation site [posttranslational modification] 330214002151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002152 ATP binding site [chemical binding]; other site 330214002153 Mg2+ binding site [ion binding]; other site 330214002154 G-X-G motif; other site 330214002155 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214002156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002157 active site 330214002158 phosphorylation site [posttranslational modification] 330214002159 intermolecular recognition site; other site 330214002160 dimerization interface [polypeptide binding]; other site 330214002161 Response regulator receiver domain; Region: Response_reg; pfam00072 330214002162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002163 active site 330214002164 phosphorylation site [posttranslational modification] 330214002165 intermolecular recognition site; other site 330214002166 dimerization interface [polypeptide binding]; other site 330214002167 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214002168 putative binding surface; other site 330214002169 active site 330214002170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002171 dimer interface [polypeptide binding]; other site 330214002172 phosphorylation site [posttranslational modification] 330214002173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002174 ATP binding site [chemical binding]; other site 330214002175 Mg2+ binding site [ion binding]; other site 330214002176 G-X-G motif; other site 330214002177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002178 active site 330214002179 phosphorylation site [posttranslational modification] 330214002180 intermolecular recognition site; other site 330214002181 dimerization interface [polypeptide binding]; other site 330214002182 Response regulator receiver domain; Region: Response_reg; pfam00072 330214002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002184 active site 330214002185 phosphorylation site [posttranslational modification] 330214002186 intermolecular recognition site; other site 330214002187 dimerization interface [polypeptide binding]; other site 330214002188 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 330214002189 putative binding surface; other site 330214002190 active site 330214002191 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 330214002192 Cytochrome c; Region: Cytochrom_C; pfam00034 330214002193 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214002194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 330214002195 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 330214002196 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 330214002197 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 330214002198 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 330214002199 TPP-binding site [chemical binding]; other site 330214002200 dimer interface [polypeptide binding]; other site 330214002201 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 330214002202 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 330214002203 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552 330214002204 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 330214002205 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 330214002206 dimer interface [polypeptide binding]; other site 330214002207 PYR/PP interface [polypeptide binding]; other site 330214002208 TPP binding site [chemical binding]; other site 330214002209 substrate binding site [chemical binding]; other site 330214002210 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214002211 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 330214002212 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 330214002213 active site 330214002214 catalytic residues [active] 330214002215 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 330214002216 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 330214002217 DNA binding site [nucleotide binding] 330214002218 catalytic residue [active] 330214002219 H2TH interface [polypeptide binding]; other site 330214002220 putative catalytic residues [active] 330214002221 turnover-facilitating residue; other site 330214002222 intercalation triad [nucleotide binding]; other site 330214002223 8OG recognition residue [nucleotide binding]; other site 330214002224 putative reading head residues; other site 330214002225 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 330214002226 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 330214002227 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 330214002228 ATP citrate (pro-S)-lyase; Region: PLN02235 330214002229 CoA binding domain; Region: CoA_binding; smart00881 330214002230 ATP citrate (pro-S)-lyase; Region: PLN02522 330214002231 CoA-ligase; Region: Ligase_CoA; pfam00549 330214002232 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 330214002233 active site 330214002234 oxalacetate binding site [chemical binding]; other site 330214002235 citrylCoA binding site [chemical binding]; other site 330214002236 coenzyme A binding site [chemical binding]; other site 330214002237 catalytic triad [active] 330214002238 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 330214002239 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 330214002240 substrate binding site [chemical binding]; other site 330214002241 ligand binding site [chemical binding]; other site 330214002242 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 330214002243 substrate binding site [chemical binding]; other site 330214002244 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 330214002245 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 330214002246 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 330214002247 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 330214002248 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 330214002249 FAD binding domain; Region: FAD_binding_2; pfam00890 330214002250 L-aspartate oxidase; Provisional; Region: PRK06175 330214002251 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 330214002252 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 330214002253 CoA-ligase; Region: Ligase_CoA; pfam00549 330214002254 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 330214002255 CoA binding domain; Region: CoA_binding; smart00881 330214002256 CoA-ligase; Region: Ligase_CoA; pfam00549 330214002257 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 330214002258 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 330214002259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214002260 FeS/SAM binding site; other site 330214002261 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 330214002262 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 330214002263 homotetramer interface [polypeptide binding]; other site 330214002264 ligand binding site [chemical binding]; other site 330214002265 catalytic site [active] 330214002266 NAD binding site [chemical binding]; other site 330214002267 S-adenosylmethionine synthetase; Validated; Region: PRK05250 330214002268 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 330214002269 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 330214002270 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 330214002271 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 330214002272 ResB-like family; Region: ResB; pfam05140 330214002273 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 330214002274 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 330214002275 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214002276 catalytic residues [active] 330214002277 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 330214002278 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214002279 catalytic residues [active] 330214002280 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 330214002281 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 330214002282 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 330214002283 hypothetical protein; Provisional; Region: PRK07236 330214002284 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 330214002285 Tetratricopeptide repeat; Region: TPR_6; pfam13174 330214002286 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 330214002287 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 330214002288 dimer interface [polypeptide binding]; other site 330214002289 active site 330214002290 CoA binding pocket [chemical binding]; other site 330214002291 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 330214002292 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 330214002293 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 330214002294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214002295 dimerization interface [polypeptide binding]; other site 330214002296 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214002297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002298 putative active site [active] 330214002299 heme pocket [chemical binding]; other site 330214002300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002301 dimer interface [polypeptide binding]; other site 330214002302 phosphorylation site [posttranslational modification] 330214002303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002304 ATP binding site [chemical binding]; other site 330214002305 Mg2+ binding site [ion binding]; other site 330214002306 G-X-G motif; other site 330214002307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 330214002308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002309 active site 330214002310 phosphorylation site [posttranslational modification] 330214002311 intermolecular recognition site; other site 330214002312 dimerization interface [polypeptide binding]; other site 330214002313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 330214002314 DNA binding site [nucleotide binding] 330214002315 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 330214002316 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 330214002317 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 330214002318 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 330214002319 Walker A/P-loop; other site 330214002320 ATP binding site [chemical binding]; other site 330214002321 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 330214002322 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 330214002323 ABC transporter signature motif; other site 330214002324 Walker B; other site 330214002325 D-loop; other site 330214002326 H-loop/switch region; other site 330214002327 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 330214002328 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 330214002329 Active site cavity [active] 330214002330 catalytic acid [active] 330214002331 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 330214002332 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 330214002333 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 330214002334 Permease; Region: Permease; pfam02405 330214002335 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 330214002336 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 330214002337 Walker A/P-loop; other site 330214002338 ATP binding site [chemical binding]; other site 330214002339 Q-loop/lid; other site 330214002340 ABC transporter signature motif; other site 330214002341 Walker B; other site 330214002342 D-loop; other site 330214002343 H-loop/switch region; other site 330214002344 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 330214002345 mce related protein; Region: MCE; pfam02470 330214002346 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 330214002347 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214002348 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 330214002349 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 330214002350 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 330214002351 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 330214002352 TPP-binding site; other site 330214002353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 330214002354 PYR/PP interface [polypeptide binding]; other site 330214002355 dimer interface [polypeptide binding]; other site 330214002356 TPP binding site [chemical binding]; other site 330214002357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214002358 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 330214002359 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 330214002360 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 330214002361 putative cation:proton antiport protein; Provisional; Region: PRK10669 330214002362 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 330214002363 TrkA-N domain; Region: TrkA_N; pfam02254 330214002364 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 330214002365 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 330214002366 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214002367 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214002368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214002369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214002370 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 330214002371 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 330214002372 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 330214002373 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 330214002374 Ligand binding site; other site 330214002375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214002376 S-adenosylmethionine binding site [chemical binding]; other site 330214002377 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 330214002378 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 330214002379 inhibitor-cofactor binding pocket; inhibition site 330214002380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214002381 catalytic residue [active] 330214002382 Bacterial sugar transferase; Region: Bac_transf; pfam02397 330214002383 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 330214002384 CoA binding domain; Region: CoA_binding; smart00881 330214002385 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 330214002386 NAD(P) binding site [chemical binding]; other site 330214002387 homodimer interface [polypeptide binding]; other site 330214002388 substrate binding site [chemical binding]; other site 330214002389 active site 330214002390 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 330214002391 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214002392 SLBB domain; Region: SLBB; pfam10531 330214002393 SLBB domain; Region: SLBB; pfam10531 330214002394 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 330214002395 SLBB domain; Region: SLBB; pfam10531 330214002396 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 330214002397 Chain length determinant protein; Region: Wzz; pfam02706 330214002398 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 330214002399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214002400 FeS/SAM binding site; other site 330214002401 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 330214002402 Cytochrome c; Region: Cytochrom_C; pfam00034 330214002403 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 330214002404 Membrane-associating domain; Region: MARVEL; pfam01284 330214002405 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 330214002406 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 330214002407 iron-sulfur cluster [ion binding]; other site 330214002408 [2Fe-2S] cluster binding site [ion binding]; other site 330214002409 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 330214002410 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 330214002411 heme bH binding site [chemical binding]; other site 330214002412 intrachain domain interface; other site 330214002413 Qi binding site; other site 330214002414 heme bL binding site [chemical binding]; other site 330214002415 interchain domain interface [polypeptide binding]; other site 330214002416 Qo binding site; other site 330214002417 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 330214002418 interchain domain interface [polypeptide binding]; other site 330214002419 intrachain domain interface; other site 330214002420 Qi binding site; other site 330214002421 Qo binding site; other site 330214002422 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 330214002423 Cytochrome c; Region: Cytochrom_C; pfam00034 330214002424 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214002425 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 330214002426 putative ligand binding site [chemical binding]; other site 330214002427 Cytochrome c; Region: Cytochrom_C; pfam00034 330214002428 Cytochrome c; Region: Cytochrom_C; pfam00034 330214002429 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 330214002430 UbiA prenyltransferase family; Region: UbiA; pfam01040 330214002431 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 330214002432 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214002433 Transposase; Region: HTH_Tnp_1; pfam01527 330214002434 HTH-like domain; Region: HTH_21; pfam13276 330214002435 Integrase core domain; Region: rve; pfam00665 330214002436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 330214002437 Integrase core domain; Region: rve_3; pfam13683 330214002438 Predicted periplasmic protein [Function unknown]; Region: COG3904 330214002439 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 330214002440 active site 330214002441 ATP binding site [chemical binding]; other site 330214002442 activation loop (A-loop); other site 330214002443 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 330214002444 active site 330214002445 zinc binding site [ion binding]; other site 330214002446 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 330214002447 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 330214002448 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 330214002449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214002450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002451 active site 330214002452 phosphorylation site [posttranslational modification] 330214002453 intermolecular recognition site; other site 330214002454 dimerization interface [polypeptide binding]; other site 330214002455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214002456 DNA binding residues [nucleotide binding] 330214002457 dimerization interface [polypeptide binding]; other site 330214002458 PAS domain; Region: PAS_9; pfam13426 330214002459 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 330214002460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002461 PAS domain; Region: PAS_9; pfam13426 330214002462 putative active site [active] 330214002463 heme pocket [chemical binding]; other site 330214002464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 330214002465 Histidine kinase; Region: HisKA_3; pfam07730 330214002466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002467 ATP binding site [chemical binding]; other site 330214002468 Mg2+ binding site [ion binding]; other site 330214002469 G-X-G motif; other site 330214002470 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 330214002471 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 330214002472 active site 330214002473 catalytic site [active] 330214002474 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 330214002475 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 330214002476 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 330214002477 metal ion-dependent adhesion site (MIDAS); other site 330214002478 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214002479 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214002480 ligand binding site [chemical binding]; other site 330214002481 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 330214002482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214002483 S-adenosylmethionine binding site [chemical binding]; other site 330214002484 CHASE2 domain; Region: CHASE2; pfam05226 330214002485 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 330214002486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214002487 Walker A motif; other site 330214002488 ATP binding site [chemical binding]; other site 330214002489 Walker B motif; other site 330214002490 arginine finger; other site 330214002491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214002492 TPR motif; other site 330214002493 binding surface 330214002494 TPR repeat; Region: TPR_11; pfam13414 330214002495 TPR repeat; Region: TPR_11; pfam13414 330214002496 Sel1-like repeats; Region: SEL1; smart00671 330214002497 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 330214002498 nucleotide binding site/active site [active] 330214002499 HIT family signature motif; other site 330214002500 catalytic residue [active] 330214002501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214002502 Zn2+ binding site [ion binding]; other site 330214002503 Mg2+ binding site [ion binding]; other site 330214002504 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 330214002505 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 330214002506 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214002507 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214002508 proteasome ATPase; Region: pup_AAA; TIGR03689 330214002509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214002510 Walker A motif; other site 330214002511 ATP binding site [chemical binding]; other site 330214002512 Walker B motif; other site 330214002513 arginine finger; other site 330214002514 Pup-ligase protein; Region: Pup_ligase; pfam03136 330214002515 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 330214002516 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 330214002517 active site 330214002518 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 330214002519 active site 330214002520 Pup-ligase protein; Region: Pup_ligase; pfam03136 330214002521 PilZ domain; Region: PilZ; pfam07238 330214002522 acyl transferase; Provisional; Region: luxD; PRK13604 330214002523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 330214002524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214002526 S-adenosylmethionine binding site [chemical binding]; other site 330214002527 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214002528 GAF domain; Region: GAF_3; pfam13492 330214002529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002530 dimer interface [polypeptide binding]; other site 330214002531 phosphorylation site [posttranslational modification] 330214002532 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 330214002533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002534 ATP binding site [chemical binding]; other site 330214002535 Mg2+ binding site [ion binding]; other site 330214002536 G-X-G motif; other site 330214002537 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 330214002538 Putative serine esterase (DUF676); Region: DUF676; pfam05057 330214002539 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 330214002540 active site 330214002541 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 330214002542 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 330214002543 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 330214002544 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 330214002545 TPP-binding site [chemical binding]; other site 330214002546 dimer interface [polypeptide binding]; other site 330214002547 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 330214002548 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 330214002549 dimer interface [polypeptide binding]; other site 330214002550 PYR/PP interface [polypeptide binding]; other site 330214002551 TPP binding site [chemical binding]; other site 330214002552 substrate binding site [chemical binding]; other site 330214002553 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214002554 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552 330214002555 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 330214002556 transcription termination factor Rho; Provisional; Region: rho; PRK09376 330214002557 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 330214002558 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 330214002559 RNA binding site [nucleotide binding]; other site 330214002560 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 330214002561 multimer interface [polypeptide binding]; other site 330214002562 Walker A motif; other site 330214002563 ATP binding site [chemical binding]; other site 330214002564 Walker B motif; other site 330214002565 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 330214002566 peptide chain release factor 1; Validated; Region: prfA; PRK00591 330214002567 This domain is found in peptide chain release factors; Region: PCRF; smart00937 330214002568 RF-1 domain; Region: RF-1; pfam00472 330214002569 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 330214002570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214002571 S-adenosylmethionine binding site [chemical binding]; other site 330214002572 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 330214002573 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 330214002574 hinge; other site 330214002575 active site 330214002576 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 330214002577 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 330214002578 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 330214002579 histidinol dehydrogenase; Region: hisD; TIGR00069 330214002580 NAD binding site [chemical binding]; other site 330214002581 dimerization interface [polypeptide binding]; other site 330214002582 product binding site; other site 330214002583 substrate binding site [chemical binding]; other site 330214002584 zinc binding site [ion binding]; other site 330214002585 catalytic residues [active] 330214002586 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 330214002587 putative active site pocket [active] 330214002588 4-fold oligomerization interface [polypeptide binding]; other site 330214002589 metal binding residues [ion binding]; metal-binding site 330214002590 3-fold/trimer interface [polypeptide binding]; other site 330214002591 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 330214002592 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 330214002593 putative active site [active] 330214002594 oxyanion strand; other site 330214002595 catalytic triad [active] 330214002596 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 330214002597 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 330214002598 catalytic residues [active] 330214002599 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 330214002600 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 330214002601 substrate binding site [chemical binding]; other site 330214002602 glutamase interaction surface [polypeptide binding]; other site 330214002603 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 330214002604 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 330214002605 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 330214002606 metal binding site [ion binding]; metal-binding site 330214002607 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 330214002608 nucleotide binding site/active site [active] 330214002609 HIT family signature motif; other site 330214002610 catalytic residue [active] 330214002611 DNA primase; Validated; Region: dnaG; PRK05667 330214002612 CHC2 zinc finger; Region: zf-CHC2; pfam01807 330214002613 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 330214002614 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 330214002615 active site 330214002616 metal binding site [ion binding]; metal-binding site 330214002617 interdomain interaction site; other site 330214002618 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 330214002619 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 330214002620 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 330214002621 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 330214002622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214002623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 330214002624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214002625 DNA binding residues [nucleotide binding] 330214002626 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 330214002627 Putative zinc ribbon domain; Region: DUF164; pfam02591 330214002628 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 330214002629 RNA/DNA hybrid binding site [nucleotide binding]; other site 330214002630 active site 330214002631 Peptidase family M48; Region: Peptidase_M48; pfam01435 330214002632 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 330214002633 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 330214002634 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 330214002635 PYR/PP interface [polypeptide binding]; other site 330214002636 dimer interface [polypeptide binding]; other site 330214002637 TPP binding site [chemical binding]; other site 330214002638 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 330214002639 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 330214002640 TPP-binding site [chemical binding]; other site 330214002641 dimer interface [polypeptide binding]; other site 330214002642 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 330214002643 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 330214002644 putative valine binding site [chemical binding]; other site 330214002645 dimer interface [polypeptide binding]; other site 330214002646 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 330214002647 ketol-acid reductoisomerase; Provisional; Region: PRK05479 330214002648 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 330214002649 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 330214002650 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 330214002651 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 330214002652 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 330214002653 2-isopropylmalate synthase; Validated; Region: PRK00915 330214002654 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 330214002655 active site 330214002656 catalytic residues [active] 330214002657 metal binding site [ion binding]; metal-binding site 330214002658 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 330214002659 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 330214002660 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 330214002661 tartrate dehydrogenase; Region: TTC; TIGR02089 330214002662 NHL repeat; Region: NHL; pfam01436 330214002663 NHL repeat; Region: NHL; pfam01436 330214002664 NHL repeat; Region: NHL; pfam01436 330214002665 NHL repeat; Region: NHL; pfam01436 330214002666 NHL repeat; Region: NHL; pfam01436 330214002667 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 330214002668 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 330214002669 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 330214002670 Stage II sporulation protein; Region: SpoIID; pfam08486 330214002671 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 330214002672 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 330214002673 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 330214002674 SurA N-terminal domain; Region: SurA_N_3; pfam13624 330214002675 RDD family; Region: RDD; pfam06271 330214002676 rod shape-determining protein MreB; Provisional; Region: PRK13927 330214002677 MreB and similar proteins; Region: MreB_like; cd10225 330214002678 nucleotide binding site [chemical binding]; other site 330214002679 Mg binding site [ion binding]; other site 330214002680 putative protofilament interaction site [polypeptide binding]; other site 330214002681 RodZ interaction site [polypeptide binding]; other site 330214002682 rod shape-determining protein MreC; Provisional; Region: PRK13922 330214002683 rod shape-determining protein MreC; Region: MreC; pfam04085 330214002684 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 330214002685 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 330214002686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 330214002687 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 330214002688 ribonuclease G; Provisional; Region: PRK11712 330214002689 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 330214002690 homodimer interface [polypeptide binding]; other site 330214002691 oligonucleotide binding site [chemical binding]; other site 330214002692 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 330214002693 DNA protecting protein DprA; Region: dprA; TIGR00732 330214002694 DNA topoisomerase I; Validated; Region: PRK06599 330214002695 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 330214002696 active site 330214002697 interdomain interaction site; other site 330214002698 putative metal-binding site [ion binding]; other site 330214002699 nucleotide binding site [chemical binding]; other site 330214002700 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 330214002701 domain I; other site 330214002702 DNA binding groove [nucleotide binding] 330214002703 phosphate binding site [ion binding]; other site 330214002704 domain II; other site 330214002705 domain III; other site 330214002706 nucleotide binding site [chemical binding]; other site 330214002707 catalytic site [active] 330214002708 domain IV; other site 330214002709 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 330214002710 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 330214002711 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 330214002712 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 330214002713 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 330214002714 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 330214002715 heme binding site [chemical binding]; other site 330214002716 ferroxidase pore; other site 330214002717 ferroxidase diiron center [ion binding]; other site 330214002718 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 330214002719 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 330214002720 heme binding site [chemical binding]; other site 330214002721 ferroxidase pore; other site 330214002722 ferroxidase diiron center [ion binding]; other site 330214002723 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 330214002724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214002725 Zn2+ binding site [ion binding]; other site 330214002726 Mg2+ binding site [ion binding]; other site 330214002727 FMN-binding domain; Region: FMN_bind; pfam04205 330214002728 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 330214002729 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 330214002730 ApbE family; Region: ApbE; pfam02424 330214002731 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 330214002732 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 330214002733 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 330214002734 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 330214002735 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 330214002736 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 330214002737 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 330214002738 Walker A/P-loop; other site 330214002739 ATP binding site [chemical binding]; other site 330214002740 Q-loop/lid; other site 330214002741 ABC transporter signature motif; other site 330214002742 Walker B; other site 330214002743 D-loop; other site 330214002744 H-loop/switch region; other site 330214002745 TOBE domain; Region: TOBE_2; pfam08402 330214002746 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 330214002747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214002748 dimer interface [polypeptide binding]; other site 330214002749 conserved gate region; other site 330214002750 putative PBP binding loops; other site 330214002751 ABC-ATPase subunit interface; other site 330214002752 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 330214002753 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 330214002754 ferric uptake regulator; Provisional; Region: fur; PRK09462 330214002755 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 330214002756 metal binding site 2 [ion binding]; metal-binding site 330214002757 putative DNA binding helix; other site 330214002758 metal binding site 1 [ion binding]; metal-binding site 330214002759 dimer interface [polypeptide binding]; other site 330214002760 structural Zn2+ binding site [ion binding]; other site 330214002761 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 330214002762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214002763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002764 active site 330214002765 phosphorylation site [posttranslational modification] 330214002766 intermolecular recognition site; other site 330214002767 dimerization interface [polypeptide binding]; other site 330214002768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214002769 DNA binding residues [nucleotide binding] 330214002770 dimerization interface [polypeptide binding]; other site 330214002771 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 330214002772 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 330214002773 active site 330214002774 Zn binding site [ion binding]; other site 330214002775 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 330214002776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214002777 S-adenosylmethionine binding site [chemical binding]; other site 330214002778 EamA-like transporter family; Region: EamA; pfam00892 330214002779 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 330214002780 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214002781 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 330214002782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002783 PAS fold; Region: PAS_3; pfam08447 330214002784 putative active site [active] 330214002785 heme pocket [chemical binding]; other site 330214002786 PAS domain S-box; Region: sensory_box; TIGR00229 330214002787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002788 putative active site [active] 330214002789 heme pocket [chemical binding]; other site 330214002790 PAS domain S-box; Region: sensory_box; TIGR00229 330214002791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214002792 putative active site [active] 330214002793 heme pocket [chemical binding]; other site 330214002794 GAF domain; Region: GAF; pfam01590 330214002795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214002796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214002797 dimer interface [polypeptide binding]; other site 330214002798 phosphorylation site [posttranslational modification] 330214002799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214002800 ATP binding site [chemical binding]; other site 330214002801 Mg2+ binding site [ion binding]; other site 330214002802 G-X-G motif; other site 330214002803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002804 Response regulator receiver domain; Region: Response_reg; pfam00072 330214002805 active site 330214002806 phosphorylation site [posttranslational modification] 330214002807 intermolecular recognition site; other site 330214002808 dimerization interface [polypeptide binding]; other site 330214002809 Response regulator receiver domain; Region: Response_reg; pfam00072 330214002810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002811 active site 330214002812 phosphorylation site [posttranslational modification] 330214002813 intermolecular recognition site; other site 330214002814 dimerization interface [polypeptide binding]; other site 330214002815 Hpt domain; Region: Hpt; pfam01627 330214002816 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214002817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214002818 active site 330214002819 phosphorylation site [posttranslational modification] 330214002820 intermolecular recognition site; other site 330214002821 dimerization interface [polypeptide binding]; other site 330214002822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214002823 Walker A motif; other site 330214002824 ATP binding site [chemical binding]; other site 330214002825 Walker B motif; other site 330214002826 arginine finger; other site 330214002827 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214002828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214002829 DNA binding residues [nucleotide binding] 330214002830 dimerization interface [polypeptide binding]; other site 330214002831 SnoaL-like domain; Region: SnoaL_3; pfam13474 330214002832 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 330214002833 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 330214002834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214002835 DNA binding residues [nucleotide binding] 330214002836 dimerization interface [polypeptide binding]; other site 330214002837 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 330214002838 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 330214002839 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 330214002840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 330214002841 active site 330214002842 phosphorylation site [posttranslational modification] 330214002843 intermolecular recognition site; other site 330214002844 dimerization interface [polypeptide binding]; other site 330214002845 TPR repeat; Region: TPR_11; pfam13414 330214002846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214002847 binding surface 330214002848 TPR motif; other site 330214002849 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214002850 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 330214002851 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 330214002852 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 330214002853 ThiC-associated domain; Region: ThiC-associated; pfam13667 330214002854 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 330214002855 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 330214002856 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 330214002857 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 330214002858 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 330214002859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 330214002860 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 330214002861 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 330214002862 quinolinate synthetase; Provisional; Region: PRK09375 330214002863 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 330214002864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 330214002865 active site 330214002866 HIGH motif; other site 330214002867 nucleotide binding site [chemical binding]; other site 330214002868 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 330214002869 active site 330214002870 KMSKS motif; other site 330214002871 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 330214002872 tRNA binding surface [nucleotide binding]; other site 330214002873 anticodon binding site; other site 330214002874 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 330214002875 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 330214002876 lipoprotein signal peptidase; Provisional; Region: PRK14787 330214002877 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 330214002878 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 330214002879 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 330214002880 macrolide transporter subunit MacA; Provisional; Region: PRK11578 330214002881 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214002882 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214002883 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 330214002884 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 330214002885 Walker A/P-loop; other site 330214002886 ATP binding site [chemical binding]; other site 330214002887 Q-loop/lid; other site 330214002888 ABC transporter signature motif; other site 330214002889 Walker B; other site 330214002890 D-loop; other site 330214002891 H-loop/switch region; other site 330214002892 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214002893 FtsX-like permease family; Region: FtsX; pfam02687 330214002894 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 330214002895 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 330214002896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214002897 Zn2+ binding site [ion binding]; other site 330214002898 Mg2+ binding site [ion binding]; other site 330214002899 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 330214002900 cell division protein MraZ; Reviewed; Region: PRK00326 330214002901 MraZ protein; Region: MraZ; pfam02381 330214002902 MraZ protein; Region: MraZ; pfam02381 330214002903 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 330214002904 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 330214002905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214002906 active site 330214002907 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 330214002908 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 330214002909 Walker A/P-loop; other site 330214002910 ATP binding site [chemical binding]; other site 330214002911 Q-loop/lid; other site 330214002912 ABC transporter signature motif; other site 330214002913 Walker B; other site 330214002914 D-loop; other site 330214002915 H-loop/switch region; other site 330214002916 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 330214002917 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 330214002918 active site 330214002919 FMN binding site [chemical binding]; other site 330214002920 substrate binding site [chemical binding]; other site 330214002921 catalytic residues [active] 330214002922 homodimer interface [polypeptide binding]; other site 330214002923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214002924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214002925 DNA binding residues [nucleotide binding] 330214002926 dimerization interface [polypeptide binding]; other site 330214002927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214002928 FtsX-like permease family; Region: FtsX; pfam02687 330214002929 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 330214002930 FtsX-like permease family; Region: FtsX; pfam02687 330214002931 biotin synthase; Validated; Region: PRK06256 330214002932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214002933 FeS/SAM binding site; other site 330214002934 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 330214002935 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 330214002936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214002937 binding surface 330214002938 TPR motif; other site 330214002939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214002940 binding surface 330214002941 TPR motif; other site 330214002942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214002943 binding surface 330214002944 TPR motif; other site 330214002945 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 330214002946 Oligomerisation domain; Region: Oligomerisation; pfam02410 330214002947 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 330214002948 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 330214002949 active site 330214002950 (T/H)XGH motif; other site 330214002951 gamma-glutamyl kinase; Provisional; Region: PRK05429 330214002952 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 330214002953 nucleotide binding site [chemical binding]; other site 330214002954 homotetrameric interface [polypeptide binding]; other site 330214002955 putative phosphate binding site [ion binding]; other site 330214002956 putative allosteric binding site; other site 330214002957 PUA domain; Region: PUA; pfam01472 330214002958 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 330214002959 GTP1/OBG; Region: GTP1_OBG; pfam01018 330214002960 Obg GTPase; Region: Obg; cd01898 330214002961 G1 box; other site 330214002962 GTP/Mg2+ binding site [chemical binding]; other site 330214002963 Switch I region; other site 330214002964 G2 box; other site 330214002965 G3 box; other site 330214002966 Switch II region; other site 330214002967 G4 box; other site 330214002968 G5 box; other site 330214002969 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 330214002970 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 330214002971 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 330214002972 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 330214002973 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 330214002974 homodimer interface [polypeptide binding]; other site 330214002975 substrate-cofactor binding pocket; other site 330214002976 catalytic residue [active] 330214002977 Preprotein translocase SecG subunit; Region: SecG; pfam03840 330214002978 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 330214002979 triosephosphate isomerase; Provisional; Region: PRK14565 330214002980 substrate binding site [chemical binding]; other site 330214002981 dimer interface [polypeptide binding]; other site 330214002982 catalytic triad [active] 330214002983 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 330214002984 Phosphoglycerate kinase; Region: PGK; pfam00162 330214002985 substrate binding site [chemical binding]; other site 330214002986 hinge regions; other site 330214002987 ADP binding site [chemical binding]; other site 330214002988 catalytic site [active] 330214002989 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 330214002990 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 330214002991 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 330214002992 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 330214002993 MutS domain III; Region: MutS_III; pfam05192 330214002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214002995 Walker A/P-loop; other site 330214002996 ATP binding site [chemical binding]; other site 330214002997 Q-loop/lid; other site 330214002998 ABC transporter signature motif; other site 330214002999 Walker B; other site 330214003000 D-loop; other site 330214003001 H-loop/switch region; other site 330214003002 Smr domain; Region: Smr; pfam01713 330214003003 HAMP domain; Region: HAMP; pfam00672 330214003004 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214003005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214003006 putative active site [active] 330214003007 heme pocket [chemical binding]; other site 330214003008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214003009 dimer interface [polypeptide binding]; other site 330214003010 phosphorylation site [posttranslational modification] 330214003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214003012 ATP binding site [chemical binding]; other site 330214003013 Mg2+ binding site [ion binding]; other site 330214003014 G-X-G motif; other site 330214003015 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003017 active site 330214003018 phosphorylation site [posttranslational modification] 330214003019 intermolecular recognition site; other site 330214003020 dimerization interface [polypeptide binding]; other site 330214003021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214003022 DNA binding residues [nucleotide binding] 330214003023 dimerization interface [polypeptide binding]; other site 330214003024 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214003025 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 330214003026 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214003027 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214003028 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214003029 CHASE2 domain; Region: CHASE2; pfam05226 330214003030 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 330214003031 cyclase homology domain; Region: CHD; cd07302 330214003032 nucleotidyl binding site; other site 330214003033 metal binding site [ion binding]; metal-binding site 330214003034 dimer interface [polypeptide binding]; other site 330214003035 Bacterial SH3 domain homologues; Region: SH3b; smart00287 330214003036 Peptidase family M48; Region: Peptidase_M48; cl12018 330214003037 Cache domain; Region: Cache_1; pfam02743 330214003038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214003039 dimer interface [polypeptide binding]; other site 330214003040 phosphorylation site [posttranslational modification] 330214003041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214003042 ATP binding site [chemical binding]; other site 330214003043 Mg2+ binding site [ion binding]; other site 330214003044 G-X-G motif; other site 330214003045 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214003046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003047 active site 330214003048 phosphorylation site [posttranslational modification] 330214003049 intermolecular recognition site; other site 330214003050 dimerization interface [polypeptide binding]; other site 330214003051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214003052 Walker A motif; other site 330214003053 ATP binding site [chemical binding]; other site 330214003054 Walker B motif; other site 330214003055 arginine finger; other site 330214003056 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214003057 epoxyqueuosine reductase; Region: TIGR00276 330214003058 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 330214003059 4Fe-4S binding domain; Region: Fer4; pfam00037 330214003060 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214003061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003062 active site 330214003063 phosphorylation site [posttranslational modification] 330214003064 intermolecular recognition site; other site 330214003065 dimerization interface [polypeptide binding]; other site 330214003066 PAS fold; Region: PAS; pfam00989 330214003067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214003068 putative active site [active] 330214003069 heme pocket [chemical binding]; other site 330214003070 hydrophobic ligand binding site; other site 330214003071 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc; pfam03364 330214003072 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 330214003073 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 330214003074 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 330214003075 Ligand Binding Site [chemical binding]; other site 330214003076 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 330214003077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 330214003078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214003079 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 330214003080 dephospho-CoA kinase; Region: TIGR00152 330214003081 CoA-binding site [chemical binding]; other site 330214003082 ATP-binding [chemical binding]; other site 330214003083 putative pectinesterase; Region: PLN02432; cl01911 330214003084 Right handed beta helix region; Region: Beta_helix; pfam13229 330214003085 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 330214003086 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 330214003087 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 330214003088 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 330214003089 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 330214003090 Domain of unknown function (DUF336); Region: DUF336; pfam03928 330214003091 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 330214003092 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 330214003093 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 330214003094 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 330214003095 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 330214003096 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 330214003097 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 330214003098 active site 330214003099 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 330214003100 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 330214003101 Moco binding site; other site 330214003102 metal coordination site [ion binding]; other site 330214003103 Uncharacterized conserved protein [Function unknown]; Region: COG0398 330214003104 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 330214003105 mercuric reductase; Validated; Region: PRK06370 330214003106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214003107 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 330214003108 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 330214003109 DHH family; Region: DHH; pfam01368 330214003110 FOG: CBS domain [General function prediction only]; Region: COG0517 330214003111 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 330214003112 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 330214003113 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 330214003114 active site 330214003115 NTP binding site [chemical binding]; other site 330214003116 metal binding triad [ion binding]; metal-binding site 330214003117 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 330214003118 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 330214003119 putative active site [active] 330214003120 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 330214003121 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 330214003122 benzoate transport; Region: 2A0115; TIGR00895 330214003123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214003124 putative substrate translocation pore; other site 330214003125 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 330214003126 HSP70 interaction site [polypeptide binding]; other site 330214003127 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 330214003128 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 330214003129 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 330214003130 active site 330214003131 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214003132 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 330214003133 homodimer interface [polypeptide binding]; other site 330214003134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214003135 catalytic residue [active] 330214003136 CAAX protease self-immunity; Region: Abi; pfam02517 330214003137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214003138 NADH(P)-binding; Region: NAD_binding_10; pfam13460 330214003139 NAD(P) binding site [chemical binding]; other site 330214003140 active site 330214003141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214003142 Histidine kinase; Region: HisKA_3; pfam07730 330214003143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214003144 ATP binding site [chemical binding]; other site 330214003145 Mg2+ binding site [ion binding]; other site 330214003146 G-X-G motif; other site 330214003147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214003148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003149 active site 330214003150 phosphorylation site [posttranslational modification] 330214003151 intermolecular recognition site; other site 330214003152 dimerization interface [polypeptide binding]; other site 330214003153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214003154 DNA binding residues [nucleotide binding] 330214003155 dimerization interface [polypeptide binding]; other site 330214003156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214003157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003158 active site 330214003159 phosphorylation site [posttranslational modification] 330214003160 intermolecular recognition site; other site 330214003161 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 330214003162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214003163 ATP binding site [chemical binding]; other site 330214003164 putative Mg++ binding site [ion binding]; other site 330214003165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214003166 nucleotide binding region [chemical binding]; other site 330214003167 ATP-binding site [chemical binding]; other site 330214003168 DEAD/H associated; Region: DEAD_assoc; pfam08494 330214003169 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214003170 Ligand Binding Site [chemical binding]; other site 330214003171 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214003172 Ligand Binding Site [chemical binding]; other site 330214003173 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 330214003174 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 330214003175 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 330214003176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 330214003177 Protein of unknown function DUF86; Region: DUF86; cl01031 330214003178 Protein of unknown function DUF86; Region: DUF86; pfam01934 330214003179 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 330214003180 active site 330214003181 NTP binding site [chemical binding]; other site 330214003182 metal binding triad [ion binding]; metal-binding site 330214003183 antibiotic binding site [chemical binding]; other site 330214003184 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 330214003185 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 330214003186 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 330214003187 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 330214003188 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 330214003189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 330214003190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214003191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 330214003192 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 330214003193 putative acyl-acceptor binding pocket; other site 330214003194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 330214003195 acyl-activating enzyme (AAE) consensus motif; other site 330214003196 AMP binding site [chemical binding]; other site 330214003197 active site 330214003198 CoA binding site [chemical binding]; other site 330214003199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214003200 Walker A/P-loop; other site 330214003201 ATP binding site [chemical binding]; other site 330214003202 Q-loop/lid; other site 330214003203 ABC transporter signature motif; other site 330214003204 Walker B; other site 330214003205 D-loop; other site 330214003206 H-loop/switch region; other site 330214003207 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 330214003208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214003209 S-adenosylmethionine binding site [chemical binding]; other site 330214003210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 330214003211 MOSC domain; Region: MOSC; pfam03473 330214003212 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214003213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214003214 S-adenosylmethionine binding site [chemical binding]; other site 330214003215 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214003216 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214003217 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 330214003218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 330214003219 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 330214003220 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 330214003221 dimer interface [polypeptide binding]; other site 330214003222 substrate binding site [chemical binding]; other site 330214003223 ATP binding site [chemical binding]; other site 330214003224 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 330214003225 Putative transcription activator [Transcription]; Region: TenA; COG0819 330214003226 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 330214003227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214003228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 330214003229 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 330214003230 dimer interface [polypeptide binding]; other site 330214003231 catalytic triad [active] 330214003232 peroxidatic and resolving cysteines [active] 330214003233 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 330214003234 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 330214003235 pyruvate carboxylase subunit B; Validated; Region: PRK09282 330214003236 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 330214003237 active site 330214003238 catalytic residues [active] 330214003239 metal binding site [ion binding]; metal-binding site 330214003240 homodimer binding site [polypeptide binding]; other site 330214003241 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 330214003242 carboxyltransferase (CT) interaction site; other site 330214003243 biotinylation site [posttranslational modification]; other site 330214003244 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 330214003245 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 330214003246 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 330214003247 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 330214003248 IPT/TIG domain; Region: TIG; pfam01833 330214003249 PBP superfamily domain; Region: PBP_like_2; cl17296 330214003250 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 330214003251 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 330214003252 EamA-like transporter family; Region: EamA; pfam00892 330214003253 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 330214003254 Fatty acid desaturase; Region: FA_desaturase; pfam00487 330214003255 Di-iron ligands [ion binding]; other site 330214003256 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 330214003257 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 330214003258 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 330214003259 substrate binding site [chemical binding]; other site 330214003260 active site 330214003261 Ferrochelatase; Region: Ferrochelatase; pfam00762 330214003262 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 330214003263 C-terminal domain interface [polypeptide binding]; other site 330214003264 active site 330214003265 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 330214003266 active site 330214003267 N-terminal domain interface [polypeptide binding]; other site 330214003268 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 330214003269 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 330214003270 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 330214003271 homodimer interface [polypeptide binding]; other site 330214003272 metal binding site [ion binding]; metal-binding site 330214003273 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 330214003274 homodimer interface [polypeptide binding]; other site 330214003275 active site 330214003276 putative chemical substrate binding site [chemical binding]; other site 330214003277 metal binding site [ion binding]; metal-binding site 330214003278 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 330214003279 LysE type translocator; Region: LysE; cl00565 330214003280 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 330214003281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214003282 dimerization interface [polypeptide binding]; other site 330214003283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214003284 putative active site [active] 330214003285 heme pocket [chemical binding]; other site 330214003286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214003287 dimer interface [polypeptide binding]; other site 330214003288 phosphorylation site [posttranslational modification] 330214003289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214003290 ATP binding site [chemical binding]; other site 330214003291 Mg2+ binding site [ion binding]; other site 330214003292 G-X-G motif; other site 330214003293 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214003294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003295 active site 330214003296 phosphorylation site [posttranslational modification] 330214003297 intermolecular recognition site; other site 330214003298 dimerization interface [polypeptide binding]; other site 330214003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214003300 Walker A motif; other site 330214003301 ATP binding site [chemical binding]; other site 330214003302 Walker B motif; other site 330214003303 arginine finger; other site 330214003304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214003305 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 330214003306 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 330214003307 dimerization interface [polypeptide binding]; other site 330214003308 putative ATP binding site [chemical binding]; other site 330214003309 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 330214003310 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 330214003311 active site 330214003312 substrate binding site [chemical binding]; other site 330214003313 cosubstrate binding site; other site 330214003314 catalytic site [active] 330214003315 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 330214003316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214003317 dimer interface [polypeptide binding]; other site 330214003318 phosphorylation site [posttranslational modification] 330214003319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214003320 ATP binding site [chemical binding]; other site 330214003321 Mg2+ binding site [ion binding]; other site 330214003322 G-X-G motif; other site 330214003323 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214003324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003325 active site 330214003326 phosphorylation site [posttranslational modification] 330214003327 intermolecular recognition site; other site 330214003328 dimerization interface [polypeptide binding]; other site 330214003329 Response regulator receiver domain; Region: Response_reg; pfam00072 330214003330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003331 active site 330214003332 phosphorylation site [posttranslational modification] 330214003333 intermolecular recognition site; other site 330214003334 Response regulator receiver domain; Region: Response_reg; pfam00072 330214003335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003336 active site 330214003337 phosphorylation site [posttranslational modification] 330214003338 intermolecular recognition site; other site 330214003339 dimerization interface [polypeptide binding]; other site 330214003340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 330214003341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 330214003342 metal binding site [ion binding]; metal-binding site 330214003343 active site 330214003344 I-site; other site 330214003345 Response regulator receiver domain; Region: Response_reg; pfam00072 330214003346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003347 active site 330214003348 phosphorylation site [posttranslational modification] 330214003349 intermolecular recognition site; other site 330214003350 dimerization interface [polypeptide binding]; other site 330214003351 Yqey-like protein; Region: YqeY; pfam09424 330214003352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 330214003353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214003354 putative substrate translocation pore; other site 330214003355 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 330214003356 catalytic residues [active] 330214003357 dimer interface [polypeptide binding]; other site 330214003358 Peptidase family M48; Region: Peptidase_M48; cl12018 330214003359 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 330214003360 substrate binding pocket [chemical binding]; other site 330214003361 substrate-Mg2+ binding site; other site 330214003362 aspartate-rich region 1; other site 330214003363 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 330214003364 aspartate-rich region 2; other site 330214003365 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 330214003366 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 330214003367 dimer interface [polypeptide binding]; other site 330214003368 [2Fe-2S] cluster binding site [ion binding]; other site 330214003369 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 330214003370 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 330214003371 hexamer interface [polypeptide binding]; other site 330214003372 ligand binding site [chemical binding]; other site 330214003373 putative active site [active] 330214003374 NAD(P) binding site [chemical binding]; other site 330214003375 Acylphosphatase; Region: Acylphosphatase; pfam00708 330214003376 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 330214003377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 330214003378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214003379 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 330214003380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214003381 DNA binding residues [nucleotide binding] 330214003382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214003383 active site 330214003384 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 330214003385 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 330214003386 Ligand Binding Site [chemical binding]; other site 330214003387 Cytochrome c; Region: Cytochrom_C; pfam00034 330214003388 SPFH domain / Band 7 family; Region: Band_7; pfam01145 330214003389 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 330214003390 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 330214003391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214003392 dimer interface [polypeptide binding]; other site 330214003393 phosphorylation site [posttranslational modification] 330214003394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214003395 ATP binding site [chemical binding]; other site 330214003396 G-X-G motif; other site 330214003397 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214003398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003399 active site 330214003400 phosphorylation site [posttranslational modification] 330214003401 intermolecular recognition site; other site 330214003402 dimerization interface [polypeptide binding]; other site 330214003403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214003404 Walker A motif; other site 330214003405 ATP binding site [chemical binding]; other site 330214003406 Walker B motif; other site 330214003407 arginine finger; other site 330214003408 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214003409 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 330214003410 AsnC family; Region: AsnC_trans_reg; pfam01037 330214003411 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214003412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003413 active site 330214003414 phosphorylation site [posttranslational modification] 330214003415 intermolecular recognition site; other site 330214003416 dimerization interface [polypeptide binding]; other site 330214003417 Fic family protein [Function unknown]; Region: COG3177 330214003418 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 330214003419 Fic/DOC family; Region: Fic; pfam02661 330214003420 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 330214003421 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 330214003422 Replication initiation factor; Region: Rep_trans; pfam02486 330214003423 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214003424 integrase; Provisional; Region: int; PHA02601 330214003425 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 330214003426 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 330214003427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214003428 active site 330214003429 DNA binding site [nucleotide binding] 330214003430 Int/Topo IB signature motif; other site 330214003431 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 330214003432 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 330214003433 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 330214003434 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 330214003435 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 330214003436 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 330214003437 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 330214003438 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 330214003439 Walker A/P-loop; other site 330214003440 ATP binding site [chemical binding]; other site 330214003441 Q-loop/lid; other site 330214003442 ABC transporter signature motif; other site 330214003443 Walker B; other site 330214003444 D-loop; other site 330214003445 H-loop/switch region; other site 330214003446 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 330214003447 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 330214003448 HEAT repeats; Region: HEAT_2; pfam13646 330214003449 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 330214003450 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 330214003451 HEAT repeats; Region: HEAT_2; pfam13646 330214003452 protein binding surface [polypeptide binding]; other site 330214003453 HEAT repeats; Region: HEAT_2; pfam13646 330214003454 HEAT repeats; Region: HEAT_2; pfam13646 330214003455 HEAT repeats; Region: HEAT_2; pfam13646 330214003456 HEAT repeats; Region: HEAT_2; pfam13646 330214003457 HEAT repeats; Region: HEAT_2; pfam13646 330214003458 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 330214003459 putative homodimer interface [polypeptide binding]; other site 330214003460 putative active site pocket [active] 330214003461 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 330214003462 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 330214003463 Part of AAA domain; Region: AAA_19; pfam13245 330214003464 Family description; Region: UvrD_C_2; pfam13538 330214003465 elongation factor Tu; Reviewed; Region: PRK00049 330214003466 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 330214003467 G1 box; other site 330214003468 GEF interaction site [polypeptide binding]; other site 330214003469 GTP/Mg2+ binding site [chemical binding]; other site 330214003470 Switch I region; other site 330214003471 G2 box; other site 330214003472 G3 box; other site 330214003473 Switch II region; other site 330214003474 G4 box; other site 330214003475 G5 box; other site 330214003476 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 330214003477 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 330214003478 Antibiotic Binding Site [chemical binding]; other site 330214003479 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 330214003480 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 330214003481 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 330214003482 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 330214003483 putative homodimer interface [polypeptide binding]; other site 330214003484 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 330214003485 heterodimer interface [polypeptide binding]; other site 330214003486 homodimer interface [polypeptide binding]; other site 330214003487 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 330214003488 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 330214003489 23S rRNA interface [nucleotide binding]; other site 330214003490 L7/L12 interface [polypeptide binding]; other site 330214003491 putative thiostrepton binding site; other site 330214003492 L25 interface [polypeptide binding]; other site 330214003493 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 330214003494 mRNA/rRNA interface [nucleotide binding]; other site 330214003495 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 330214003496 23S rRNA interface [nucleotide binding]; other site 330214003497 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 330214003498 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 330214003499 peripheral dimer interface [polypeptide binding]; other site 330214003500 core dimer interface [polypeptide binding]; other site 330214003501 L10 interface [polypeptide binding]; other site 330214003502 L11 interface [polypeptide binding]; other site 330214003503 putative EF-Tu interaction site [polypeptide binding]; other site 330214003504 putative EF-G interaction site [polypeptide binding]; other site 330214003505 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 330214003506 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 330214003507 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 330214003508 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 330214003509 RPB11 interaction site [polypeptide binding]; other site 330214003510 RPB12 interaction site [polypeptide binding]; other site 330214003511 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 330214003512 RPB3 interaction site [polypeptide binding]; other site 330214003513 RPB1 interaction site [polypeptide binding]; other site 330214003514 RPB11 interaction site [polypeptide binding]; other site 330214003515 RPB10 interaction site [polypeptide binding]; other site 330214003516 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 330214003517 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 330214003518 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 330214003519 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 330214003520 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 330214003521 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 330214003522 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 330214003523 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 330214003524 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 330214003525 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 330214003526 DNA binding site [nucleotide binding] 330214003527 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 330214003528 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 330214003529 S17 interaction site [polypeptide binding]; other site 330214003530 S8 interaction site; other site 330214003531 16S rRNA interaction site [nucleotide binding]; other site 330214003532 streptomycin interaction site [chemical binding]; other site 330214003533 23S rRNA interaction site [nucleotide binding]; other site 330214003534 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 330214003535 30S ribosomal protein S7; Validated; Region: PRK05302 330214003536 elongation factor G; Reviewed; Region: PRK00007 330214003537 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 330214003538 G1 box; other site 330214003539 putative GEF interaction site [polypeptide binding]; other site 330214003540 GTP/Mg2+ binding site [chemical binding]; other site 330214003541 Switch I region; other site 330214003542 G2 box; other site 330214003543 G3 box; other site 330214003544 Switch II region; other site 330214003545 G4 box; other site 330214003546 G5 box; other site 330214003547 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 330214003548 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 330214003549 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 330214003550 elongation factor Tu; Reviewed; Region: PRK00049 330214003551 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 330214003552 G1 box; other site 330214003553 GEF interaction site [polypeptide binding]; other site 330214003554 GTP/Mg2+ binding site [chemical binding]; other site 330214003555 Switch I region; other site 330214003556 G2 box; other site 330214003557 G3 box; other site 330214003558 Switch II region; other site 330214003559 G4 box; other site 330214003560 G5 box; other site 330214003561 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 330214003562 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 330214003563 Antibiotic Binding Site [chemical binding]; other site 330214003564 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 330214003565 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 330214003566 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 330214003567 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 330214003568 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 330214003569 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 330214003570 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 330214003571 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 330214003572 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 330214003573 putative translocon binding site; other site 330214003574 protein-rRNA interface [nucleotide binding]; other site 330214003575 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 330214003576 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 330214003577 G-X-X-G motif; other site 330214003578 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 330214003579 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 330214003580 23S rRNA interface [nucleotide binding]; other site 330214003581 5S rRNA interface [nucleotide binding]; other site 330214003582 putative antibiotic binding site [chemical binding]; other site 330214003583 L25 interface [polypeptide binding]; other site 330214003584 L27 interface [polypeptide binding]; other site 330214003585 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 330214003586 23S rRNA interface [nucleotide binding]; other site 330214003587 putative translocon interaction site; other site 330214003588 signal recognition particle (SRP54) interaction site; other site 330214003589 L23 interface [polypeptide binding]; other site 330214003590 trigger factor interaction site; other site 330214003591 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 330214003592 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 330214003593 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 330214003594 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 330214003595 RNA binding site [nucleotide binding]; other site 330214003596 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 330214003597 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 330214003598 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 330214003599 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 330214003600 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 330214003601 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 330214003602 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 330214003603 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 330214003604 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 330214003605 5S rRNA interface [nucleotide binding]; other site 330214003606 L27 interface [polypeptide binding]; other site 330214003607 23S rRNA interface [nucleotide binding]; other site 330214003608 L5 interface [polypeptide binding]; other site 330214003609 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 330214003610 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 330214003611 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 330214003612 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 330214003613 23S rRNA binding site [nucleotide binding]; other site 330214003614 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 330214003615 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 330214003616 SecY translocase; Region: SecY; pfam00344 330214003617 adenylate kinase; Reviewed; Region: adk; PRK00279 330214003618 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 330214003619 AMP-binding site [chemical binding]; other site 330214003620 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 330214003621 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 330214003622 active site 330214003623 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 330214003624 rRNA binding site [nucleotide binding]; other site 330214003625 predicted 30S ribosome binding site; other site 330214003626 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 330214003627 30S ribosomal protein S13; Region: bact_S13; TIGR03631 330214003628 30S ribosomal protein S11; Validated; Region: PRK05309 330214003629 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 330214003630 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 330214003631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214003632 RNA binding surface [nucleotide binding]; other site 330214003633 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 330214003634 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 330214003635 alphaNTD homodimer interface [polypeptide binding]; other site 330214003636 alphaNTD - beta interaction site [polypeptide binding]; other site 330214003637 alphaNTD - beta' interaction site [polypeptide binding]; other site 330214003638 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 330214003639 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 330214003640 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 330214003641 OstA-like protein; Region: OstA; cl00844 330214003642 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 330214003643 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 330214003644 Walker A/P-loop; other site 330214003645 ATP binding site [chemical binding]; other site 330214003646 Q-loop/lid; other site 330214003647 ABC transporter signature motif; other site 330214003648 Walker B; other site 330214003649 D-loop; other site 330214003650 H-loop/switch region; other site 330214003651 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 330214003652 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 330214003653 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 330214003654 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 330214003655 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 330214003656 30S subunit binding site; other site 330214003657 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 330214003658 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 330214003659 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 330214003660 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 330214003661 DNA binding residues [nucleotide binding] 330214003662 Competence protein A; Region: Competence_A; pfam11104 330214003663 Cell division protein FtsA; Region: FtsA; cl17206 330214003664 Cell division protein FtsA; Region: FtsA; pfam14450 330214003665 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 330214003666 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 330214003667 Pilus assembly protein, PilO; Region: PilO; cl01234 330214003668 Pilus assembly protein, PilP; Region: PilP; pfam04351 330214003669 AMIN domain; Region: AMIN; pfam11741 330214003670 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 330214003671 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 330214003672 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 330214003673 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 330214003674 active site 330214003675 dimer interface [polypeptide binding]; other site 330214003676 metal binding site [ion binding]; metal-binding site 330214003677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214003678 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214003679 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214003680 GAF domain; Region: GAF; pfam01590 330214003681 ANTAR domain; Region: ANTAR; pfam03861 330214003682 NAD synthetase; Provisional; Region: PRK13981 330214003683 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 330214003684 multimer interface [polypeptide binding]; other site 330214003685 active site 330214003686 catalytic triad [active] 330214003687 protein interface 1 [polypeptide binding]; other site 330214003688 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 330214003689 homodimer interface [polypeptide binding]; other site 330214003690 NAD binding pocket [chemical binding]; other site 330214003691 ATP binding pocket [chemical binding]; other site 330214003692 Mg binding site [ion binding]; other site 330214003693 active-site loop [active] 330214003694 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 330214003695 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 330214003696 Nitrogen regulatory protein P-II; Region: P-II; smart00938 330214003697 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 330214003698 PII uridylyl-transferase; Provisional; Region: PRK05092 330214003699 metal binding triad; other site 330214003700 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 330214003701 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 330214003702 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 330214003703 glutamine synthetase, type I; Region: GlnA; TIGR00653 330214003704 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 330214003705 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 330214003706 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 330214003707 cyanate hydratase; Validated; Region: PRK02866 330214003708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214003709 non-specific DNA binding site [nucleotide binding]; other site 330214003710 salt bridge; other site 330214003711 sequence-specific DNA binding site [nucleotide binding]; other site 330214003712 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 330214003713 oligomer interface [polypeptide binding]; other site 330214003714 active site 330214003715 MarR family; Region: MarR_2; cl17246 330214003716 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 330214003717 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 330214003718 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 330214003719 FOG: CBS domain [General function prediction only]; Region: COG0517 330214003720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214003721 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 330214003722 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 330214003723 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 330214003724 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 330214003725 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 330214003726 metal binding triad; other site 330214003727 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 330214003728 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 330214003729 metal binding triad; other site 330214003730 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 330214003731 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 330214003732 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 330214003733 ring oligomerisation interface [polypeptide binding]; other site 330214003734 ATP/Mg binding site [chemical binding]; other site 330214003735 stacking interactions; other site 330214003736 hinge regions; other site 330214003737 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 330214003738 oligomerisation interface [polypeptide binding]; other site 330214003739 mobile loop; other site 330214003740 roof hairpin; other site 330214003741 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 330214003742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214003743 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 330214003744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214003745 DNA binding residues [nucleotide binding] 330214003746 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 330214003747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214003748 putative substrate translocation pore; other site 330214003749 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 330214003750 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 330214003751 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 330214003752 dimerization interface [polypeptide binding]; other site 330214003753 active site 330214003754 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 330214003755 homopentamer interface [polypeptide binding]; other site 330214003756 active site 330214003757 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 330214003758 putative RNA binding site [nucleotide binding]; other site 330214003759 adenylosuccinate lyase; Provisional; Region: PRK07492 330214003760 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 330214003761 tetramer interface [polypeptide binding]; other site 330214003762 active site 330214003763 Chlorite dismutase; Region: Chlor_dismutase; cl01280 330214003764 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 330214003765 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 330214003766 ATP binding site [chemical binding]; other site 330214003767 active site 330214003768 substrate binding site [chemical binding]; other site 330214003769 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 330214003770 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 330214003771 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 330214003772 putative active site [active] 330214003773 catalytic triad [active] 330214003774 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 330214003775 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 330214003776 dimerization interface [polypeptide binding]; other site 330214003777 ATP binding site [chemical binding]; other site 330214003778 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 330214003779 dimerization interface [polypeptide binding]; other site 330214003780 ATP binding site [chemical binding]; other site 330214003781 amidophosphoribosyltransferase; Provisional; Region: PRK09123 330214003782 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 330214003783 active site 330214003784 tetramer interface [polypeptide binding]; other site 330214003785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214003786 active site 330214003787 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 330214003788 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 330214003789 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 330214003790 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 330214003791 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214003792 catalytic residues [active] 330214003793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 330214003794 TPR repeat; Region: TPR_11; pfam13414 330214003795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214003796 binding surface 330214003797 TPR motif; other site 330214003798 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214003799 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214003800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214003801 TPR motif; other site 330214003802 binding surface 330214003803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214003804 TPR repeat; Region: TPR_11; pfam13414 330214003805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214003806 binding surface 330214003807 TPR motif; other site 330214003808 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 330214003809 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 330214003810 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 330214003811 ssDNA binding site; other site 330214003812 generic binding surface II; other site 330214003813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214003814 ATP binding site [chemical binding]; other site 330214003815 putative Mg++ binding site [ion binding]; other site 330214003816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214003817 nucleotide binding region [chemical binding]; other site 330214003818 ATP-binding site [chemical binding]; other site 330214003819 exopolyphosphatase; Region: exo_poly_only; TIGR03706 330214003820 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 330214003821 Methyltransferase domain; Region: Methyltransf_11; pfam08241 330214003822 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 330214003823 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 330214003824 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 330214003825 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 330214003826 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 330214003827 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 330214003828 Uncharacterized conserved protein [Function unknown]; Region: COG3391 330214003829 NHL repeat; Region: NHL; pfam01436 330214003830 NHL repeat; Region: NHL; pfam01436 330214003831 NHL repeat; Region: NHL; pfam01436 330214003832 NHL repeat; Region: NHL; pfam01436 330214003833 NHL repeat; Region: NHL; pfam01436 330214003834 NHL repeat; Region: NHL; pfam01436 330214003835 Uncharacterized conserved protein [Function unknown]; Region: COG3391 330214003836 NHL repeat; Region: NHL; pfam01436 330214003837 NHL repeat; Region: NHL; pfam01436 330214003838 NHL repeat; Region: NHL; pfam01436 330214003839 NHL repeat; Region: NHL; pfam01436 330214003840 NHL repeat; Region: NHL; pfam01436 330214003841 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 330214003842 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 330214003843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 330214003844 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 330214003845 active site 330214003846 GMP synthase; Reviewed; Region: guaA; PRK00074 330214003847 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 330214003848 AMP/PPi binding site [chemical binding]; other site 330214003849 candidate oxyanion hole; other site 330214003850 catalytic triad [active] 330214003851 potential glutamine specificity residues [chemical binding]; other site 330214003852 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 330214003853 ATP Binding subdomain [chemical binding]; other site 330214003854 Ligand Binding sites [chemical binding]; other site 330214003855 Dimerization subdomain; other site 330214003856 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 330214003857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214003858 RNA binding surface [nucleotide binding]; other site 330214003859 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 330214003860 active site 330214003861 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 330214003862 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 330214003863 dimer interface [polypeptide binding]; other site 330214003864 anticodon binding site; other site 330214003865 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 330214003866 homodimer interface [polypeptide binding]; other site 330214003867 motif 1; other site 330214003868 active site 330214003869 motif 2; other site 330214003870 GAD domain; Region: GAD; pfam02938 330214003871 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 330214003872 active site 330214003873 motif 3; other site 330214003874 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 330214003875 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 330214003876 Tetramer interface [polypeptide binding]; other site 330214003877 active site 330214003878 FMN-binding site [chemical binding]; other site 330214003879 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 330214003880 RNA/DNA hybrid binding site [nucleotide binding]; other site 330214003881 active site 330214003882 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 330214003883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214003884 Walker A/P-loop; other site 330214003885 ATP binding site [chemical binding]; other site 330214003886 Q-loop/lid; other site 330214003887 ABC transporter signature motif; other site 330214003888 Walker B; other site 330214003889 D-loop; other site 330214003890 H-loop/switch region; other site 330214003891 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 330214003892 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214003893 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214003894 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 330214003895 Predicted metalloprotease [General function prediction only]; Region: COG2321 330214003896 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 330214003897 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 330214003898 pseudouridine synthase; Region: TIGR00093 330214003899 active site 330214003900 Domain of unknown function DUF302; Region: DUF302; cl01364 330214003901 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 330214003902 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 330214003903 GH3 auxin-responsive promoter; Region: GH3; pfam03321 330214003904 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 330214003905 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 330214003906 metal binding site [ion binding]; metal-binding site 330214003907 substrate binding pocket [chemical binding]; other site 330214003908 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 330214003909 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 330214003910 Moco binding site; other site 330214003911 metal coordination site [ion binding]; other site 330214003912 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 330214003913 ligand binding site [chemical binding]; other site 330214003914 active site 330214003915 UGI interface [polypeptide binding]; other site 330214003916 catalytic site [active] 330214003917 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 330214003918 active site 330214003919 zinc binding site [ion binding]; other site 330214003920 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 330214003921 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 330214003922 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 330214003923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 330214003924 Integrase core domain; Region: rve; pfam00665 330214003925 transposase; Provisional; Region: PRK06526 330214003926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214003927 Walker A motif; other site 330214003928 ATP binding site [chemical binding]; other site 330214003929 Walker B motif; other site 330214003930 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 330214003931 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 330214003932 dimer interface [polypeptide binding]; other site 330214003933 TPP-binding site [chemical binding]; other site 330214003934 Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018 330214003935 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 330214003936 TPP-binding site [chemical binding]; other site 330214003937 dimer interface [polypeptide binding]; other site 330214003938 CsbD-like; Region: CsbD; cl17424 330214003939 TPR repeat; Region: TPR_11; pfam13414 330214003940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214003941 binding surface 330214003942 TPR motif; other site 330214003943 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 330214003944 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 330214003945 DEAD-like helicases superfamily; Region: DEXDc; smart00487 330214003946 ATP binding site [chemical binding]; other site 330214003947 Mg++ binding site [ion binding]; other site 330214003948 motif III; other site 330214003949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214003950 nucleotide binding region [chemical binding]; other site 330214003951 ATP-binding site [chemical binding]; other site 330214003952 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 330214003953 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214003954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214003955 Walker B motif; other site 330214003956 arginine finger; other site 330214003957 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 330214003958 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 330214003959 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 330214003960 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214003961 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 330214003962 Ligand binding site; other site 330214003963 Putative Catalytic site; other site 330214003964 DXD motif; other site 330214003965 GtrA-like protein; Region: GtrA; pfam04138 330214003966 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 330214003967 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214003968 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214003969 catalytic residue [active] 330214003970 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 330214003971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214003972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003973 active site 330214003974 phosphorylation site [posttranslational modification] 330214003975 intermolecular recognition site; other site 330214003976 dimerization interface [polypeptide binding]; other site 330214003977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214003978 DNA binding residues [nucleotide binding] 330214003979 dimerization interface [polypeptide binding]; other site 330214003980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 330214003981 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214003982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003983 active site 330214003984 phosphorylation site [posttranslational modification] 330214003985 intermolecular recognition site; other site 330214003986 dimerization interface [polypeptide binding]; other site 330214003987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214003988 DNA binding residues [nucleotide binding] 330214003989 dimerization interface [polypeptide binding]; other site 330214003990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214003992 active site 330214003993 phosphorylation site [posttranslational modification] 330214003994 intermolecular recognition site; other site 330214003995 dimerization interface [polypeptide binding]; other site 330214003996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214003997 PAS domain; Region: PAS_9; pfam13426 330214003998 putative active site [active] 330214003999 heme pocket [chemical binding]; other site 330214004000 PAS domain S-box; Region: sensory_box; TIGR00229 330214004001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004002 putative active site [active] 330214004003 heme pocket [chemical binding]; other site 330214004004 PAS domain S-box; Region: sensory_box; TIGR00229 330214004005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004006 putative active site [active] 330214004007 heme pocket [chemical binding]; other site 330214004008 PAS domain S-box; Region: sensory_box; TIGR00229 330214004009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004010 putative active site [active] 330214004011 heme pocket [chemical binding]; other site 330214004012 PAS domain S-box; Region: sensory_box; TIGR00229 330214004013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004014 putative active site [active] 330214004015 heme pocket [chemical binding]; other site 330214004016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 330214004017 Histidine kinase; Region: HisKA_3; pfam07730 330214004018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214004019 ATP binding site [chemical binding]; other site 330214004020 Mg2+ binding site [ion binding]; other site 330214004021 G-X-G motif; other site 330214004022 Response regulator receiver domain; Region: Response_reg; pfam00072 330214004023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004024 active site 330214004025 phosphorylation site [posttranslational modification] 330214004026 intermolecular recognition site; other site 330214004027 dimerization interface [polypeptide binding]; other site 330214004028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214004029 dimer interface [polypeptide binding]; other site 330214004030 phosphorylation site [posttranslational modification] 330214004031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214004032 ATP binding site [chemical binding]; other site 330214004033 Mg2+ binding site [ion binding]; other site 330214004034 G-X-G motif; other site 330214004035 hypothetical protein; Provisional; Region: PRK09256 330214004036 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 330214004037 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 330214004038 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 330214004039 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 330214004040 Fatty acid desaturase; Region: FA_desaturase; pfam00487 330214004041 Di-iron ligands [ion binding]; other site 330214004042 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 330214004043 PilZ domain; Region: PilZ; pfam07238 330214004044 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 330214004045 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 330214004046 putative acyl-acceptor binding pocket; other site 330214004047 PilZ domain; Region: PilZ; pfam07238 330214004048 PilZ domain; Region: PilZ; pfam07238 330214004049 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 330214004050 Permease; Region: Permease; pfam02405 330214004051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214004052 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 330214004053 Walker A/P-loop; other site 330214004054 ATP binding site [chemical binding]; other site 330214004055 Q-loop/lid; other site 330214004056 ABC transporter signature motif; other site 330214004057 Walker B; other site 330214004058 D-loop; other site 330214004059 H-loop/switch region; other site 330214004060 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 330214004061 mce related protein; Region: MCE; pfam02470 330214004062 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 330214004063 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214004064 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 330214004065 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 330214004066 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 330214004067 Walker A motif; other site 330214004068 ATP binding site [chemical binding]; other site 330214004069 Walker B motif; other site 330214004070 prolyl-tRNA synthetase; Provisional; Region: PRK09194 330214004071 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 330214004072 dimer interface [polypeptide binding]; other site 330214004073 motif 1; other site 330214004074 active site 330214004075 motif 2; other site 330214004076 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 330214004077 putative deacylase active site [active] 330214004078 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 330214004079 active site 330214004080 motif 3; other site 330214004081 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 330214004082 anticodon binding site; other site 330214004083 RIP metalloprotease RseP; Region: TIGR00054 330214004084 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 330214004085 active site 330214004086 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 330214004087 protein binding site [polypeptide binding]; other site 330214004088 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 330214004089 protein binding site [polypeptide binding]; other site 330214004090 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 330214004091 putative substrate binding region [chemical binding]; other site 330214004092 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 330214004093 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 330214004094 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 330214004095 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 330214004096 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 330214004097 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 330214004098 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 330214004099 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 330214004100 catalytic residue [active] 330214004101 putative FPP diphosphate binding site; other site 330214004102 putative FPP binding hydrophobic cleft; other site 330214004103 dimer interface [polypeptide binding]; other site 330214004104 putative IPP diphosphate binding site; other site 330214004105 protease TldD; Provisional; Region: tldD; PRK10735 330214004106 peptidase PmbA; Provisional; Region: PRK11040 330214004107 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 330214004108 substrate binding site [chemical binding]; other site 330214004109 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 330214004110 Fe-S cluster binding site [ion binding]; other site 330214004111 active site 330214004112 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 330214004113 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 330214004114 active site lid residues [active] 330214004115 substrate binding pocket [chemical binding]; other site 330214004116 catalytic residues [active] 330214004117 substrate-Mg2+ binding site; other site 330214004118 aspartate-rich region 1; other site 330214004119 aspartate-rich region 2; other site 330214004120 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 330214004121 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 330214004122 cobalamin binding residues [chemical binding]; other site 330214004123 putative BtuC binding residues; other site 330214004124 dimer interface [polypeptide binding]; other site 330214004125 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 330214004126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214004127 motif II; other site 330214004128 Uncharacterized conserved protein [Function unknown]; Region: COG0432 330214004129 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 330214004130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 330214004131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 330214004132 phosphopeptide binding site; other site 330214004133 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 330214004134 Protein phosphatase 2C; Region: PP2C; pfam00481 330214004135 active site 330214004136 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 330214004137 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 330214004138 active site 330214004139 ATP binding site [chemical binding]; other site 330214004140 substrate binding site [chemical binding]; other site 330214004141 activation loop (A-loop); other site 330214004142 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 330214004143 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 330214004144 active site 330214004145 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 330214004146 Dihydroneopterin aldolase; Region: FolB; pfam02152 330214004147 active site 330214004148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214004149 S-adenosylmethionine binding site [chemical binding]; other site 330214004150 Caspase domain; Region: Peptidase_C14; pfam00656 330214004151 helicase Cas3; Provisional; Region: PRK09694 330214004152 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 330214004153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 330214004154 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 330214004155 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 330214004156 CT1975-like protein; Region: Cas_CT1975; pfam09344 330214004157 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 330214004158 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 330214004159 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 330214004160 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 330214004161 putative ssRNA endonuclease; Provisional; Region: PRK11558 330214004162 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 330214004163 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 330214004164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214004165 salt bridge; other site 330214004166 non-specific DNA binding site [nucleotide binding]; other site 330214004167 sequence-specific DNA binding site [nucleotide binding]; other site 330214004168 HipA N-terminal domain; Region: Couple_hipA; pfam13657 330214004169 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 330214004170 HipA-like N-terminal domain; Region: HipA_N; pfam07805 330214004171 HipA-like C-terminal domain; Region: HipA_C; pfam07804 330214004172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 330214004173 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214004174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 330214004175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004176 active site 330214004177 phosphorylation site [posttranslational modification] 330214004178 intermolecular recognition site; other site 330214004179 dimerization interface [polypeptide binding]; other site 330214004180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 330214004181 DNA binding site [nucleotide binding] 330214004182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214004183 dimerization interface [polypeptide binding]; other site 330214004184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214004185 dimer interface [polypeptide binding]; other site 330214004186 phosphorylation site [posttranslational modification] 330214004187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214004188 ATP binding site [chemical binding]; other site 330214004189 Mg2+ binding site [ion binding]; other site 330214004190 G-X-G motif; other site 330214004191 Protein of unknown function (DUF445); Region: DUF445; pfam04286 330214004192 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 330214004193 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 330214004194 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 330214004195 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 330214004196 trimer interface [polypeptide binding]; other site 330214004197 dimer interface [polypeptide binding]; other site 330214004198 putative active site [active] 330214004199 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 330214004200 MoaE interaction surface [polypeptide binding]; other site 330214004201 MoeB interaction surface [polypeptide binding]; other site 330214004202 thiocarboxylated glycine; other site 330214004203 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 330214004204 MoaE homodimer interface [polypeptide binding]; other site 330214004205 MoaD interaction [polypeptide binding]; other site 330214004206 active site residues [active] 330214004207 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 330214004208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214004209 FeS/SAM binding site; other site 330214004210 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 330214004211 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 330214004212 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 330214004213 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 330214004214 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 330214004215 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 330214004216 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 330214004217 OstA-like protein; Region: OstA; cl00844 330214004218 Organic solvent tolerance protein; Region: OstA_C; pfam04453 330214004219 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 330214004220 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214004221 catalytic residues [active] 330214004222 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 330214004223 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 330214004224 Walker A/P-loop; other site 330214004225 ATP binding site [chemical binding]; other site 330214004226 Q-loop/lid; other site 330214004227 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 330214004228 ABC transporter signature motif; other site 330214004229 Walker B; other site 330214004230 D-loop; other site 330214004231 H-loop/switch region; other site 330214004232 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 330214004233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004234 active site 330214004235 phosphorylation site [posttranslational modification] 330214004236 intermolecular recognition site; other site 330214004237 dimerization interface [polypeptide binding]; other site 330214004238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214004239 Zn2+ binding site [ion binding]; other site 330214004240 Mg2+ binding site [ion binding]; other site 330214004241 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214004242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004243 active site 330214004244 phosphorylation site [posttranslational modification] 330214004245 intermolecular recognition site; other site 330214004246 dimerization interface [polypeptide binding]; other site 330214004247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214004248 Walker A motif; other site 330214004249 ATP binding site [chemical binding]; other site 330214004250 Walker B motif; other site 330214004251 arginine finger; other site 330214004252 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214004253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214004254 dimer interface [polypeptide binding]; other site 330214004255 phosphorylation site [posttranslational modification] 330214004256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214004257 ATP binding site [chemical binding]; other site 330214004258 Mg2+ binding site [ion binding]; other site 330214004259 G-X-G motif; other site 330214004260 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004262 active site 330214004263 phosphorylation site [posttranslational modification] 330214004264 intermolecular recognition site; other site 330214004265 dimerization interface [polypeptide binding]; other site 330214004266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004267 PAS domain; Region: PAS_9; pfam13426 330214004268 putative active site [active] 330214004269 heme pocket [chemical binding]; other site 330214004270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214004271 PilZ domain; Region: PilZ; pfam07238 330214004272 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 330214004273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214004274 SnoaL-like domain; Region: SnoaL_3; pfam13474 330214004275 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 330214004276 active site 330214004277 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 330214004278 RNase_H superfamily; Region: RNase_H_2; pfam13482 330214004279 Cyclophilin-like; Region: Cyclophil_like; cl17583 330214004280 Protein of unknown function (DUF507); Region: DUF507; cl01112 330214004281 Protein of unknown function (DUF507); Region: DUF507; cl01112 330214004282 TPR repeat; Region: TPR_11; pfam13414 330214004283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004284 binding surface 330214004285 TPR motif; other site 330214004286 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 330214004287 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 330214004288 catalytic triad [active] 330214004289 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 330214004290 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 330214004291 NAD binding site [chemical binding]; other site 330214004292 homotetramer interface [polypeptide binding]; other site 330214004293 homodimer interface [polypeptide binding]; other site 330214004294 substrate binding site [chemical binding]; other site 330214004295 active site 330214004296 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 330214004297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214004298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214004299 DNA binding residues [nucleotide binding] 330214004300 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 330214004301 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 330214004302 Transposase; Region: HTH_Tnp_1; cl17663 330214004303 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 330214004304 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214004305 catalytic triad [active] 330214004306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214004307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214004308 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 330214004309 active site 330214004310 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 330214004311 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 330214004312 Walker A/P-loop; other site 330214004313 ATP binding site [chemical binding]; other site 330214004314 Q-loop/lid; other site 330214004315 ABC transporter signature motif; other site 330214004316 Walker B; other site 330214004317 D-loop; other site 330214004318 H-loop/switch region; other site 330214004319 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 330214004320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214004321 dimer interface [polypeptide binding]; other site 330214004322 conserved gate region; other site 330214004323 putative PBP binding loops; other site 330214004324 ABC-ATPase subunit interface; other site 330214004325 sulfate transport protein; Provisional; Region: cysT; CHL00187 330214004326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214004327 dimer interface [polypeptide binding]; other site 330214004328 conserved gate region; other site 330214004329 putative PBP binding loops; other site 330214004330 ABC-ATPase subunit interface; other site 330214004331 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 330214004332 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 330214004333 Rrf2 family protein; Region: rrf2_super; TIGR00738 330214004334 Transcriptional regulator; Region: Rrf2; pfam02082 330214004335 Putative addiction module component; Region: Unstab_antitox; pfam09720 330214004336 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 330214004337 dimer interface [polypeptide binding]; other site 330214004338 motif 1; other site 330214004339 active site 330214004340 motif 2; other site 330214004341 motif 3; other site 330214004342 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 330214004343 pyruvate phosphate dikinase; Provisional; Region: PRK09279 330214004344 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 330214004345 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 330214004346 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 330214004347 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 330214004348 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 330214004349 catalytic motif [active] 330214004350 Zn binding site [ion binding]; other site 330214004351 RibD C-terminal domain; Region: RibD_C; cl17279 330214004352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 330214004353 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 330214004354 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214004355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214004356 S-adenosylmethionine binding site [chemical binding]; other site 330214004357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214004358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 330214004359 putative substrate translocation pore; other site 330214004360 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 330214004361 Lumazine binding domain; Region: Lum_binding; pfam00677 330214004362 Lumazine binding domain; Region: Lum_binding; pfam00677 330214004363 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 330214004364 acetyl-CoA synthetase; Provisional; Region: PRK00174 330214004365 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 330214004366 active site 330214004367 CoA binding site [chemical binding]; other site 330214004368 acyl-activating enzyme (AAE) consensus motif; other site 330214004369 AMP binding site [chemical binding]; other site 330214004370 acetate binding site [chemical binding]; other site 330214004371 Caspase domain; Region: Peptidase_C14; pfam00656 330214004372 TPR repeat; Region: TPR_11; pfam13414 330214004373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004374 binding surface 330214004375 TPR motif; other site 330214004376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004377 TPR motif; other site 330214004378 binding surface 330214004379 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 330214004380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 330214004381 LPP20 lipoprotein; Region: LPP20; pfam02169 330214004382 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 330214004383 putative active site [active] 330214004384 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 330214004385 HEAT repeats; Region: HEAT_2; pfam13646 330214004386 protein binding surface [polypeptide binding]; other site 330214004387 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 330214004388 pyrroline-5-carboxylate reductase; Region: PLN02688 330214004389 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214004390 active site 330214004391 Int/Topo IB signature motif; other site 330214004392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214004393 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214004394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004395 binding surface 330214004396 TPR motif; other site 330214004397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004399 binding surface 330214004400 TPR motif; other site 330214004401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004402 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004404 binding surface 330214004405 TPR motif; other site 330214004406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004408 binding surface 330214004409 TPR motif; other site 330214004410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004411 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 330214004412 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 330214004413 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 330214004414 dimer interface [polypeptide binding]; other site 330214004415 PYR/PP interface [polypeptide binding]; other site 330214004416 TPP binding site [chemical binding]; other site 330214004417 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 330214004418 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 330214004419 TPP-binding site [chemical binding]; other site 330214004420 dimer interface [polypeptide binding]; other site 330214004421 PUA domain; Region: PUA; cl00607 330214004422 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 330214004423 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 330214004424 putative RNA binding site [nucleotide binding]; other site 330214004425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214004426 S-adenosylmethionine binding site [chemical binding]; other site 330214004427 Predicted membrane protein [Function unknown]; Region: COG1297 330214004428 putative oligopeptide transporter, OPT family; Region: TIGR00733 330214004429 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 330214004430 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 330214004431 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 330214004432 DNA repair protein RadA; Provisional; Region: PRK11823 330214004433 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 330214004434 Walker A motif/ATP binding site; other site 330214004435 ATP binding site [chemical binding]; other site 330214004436 Walker B motif; other site 330214004437 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 330214004438 Glycoprotease family; Region: Peptidase_M22; pfam00814 330214004439 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 330214004440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214004441 Coenzyme A binding pocket [chemical binding]; other site 330214004442 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 330214004443 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 330214004444 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 330214004445 active site 330214004446 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 330214004447 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214004448 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214004449 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 330214004450 Protein export membrane protein; Region: SecD_SecF; cl14618 330214004451 Response regulator receiver domain; Region: Response_reg; pfam00072 330214004452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004453 active site 330214004454 phosphorylation site [posttranslational modification] 330214004455 intermolecular recognition site; other site 330214004456 dimerization interface [polypeptide binding]; other site 330214004457 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 330214004458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214004459 H+ Antiporter protein; Region: 2A0121; TIGR00900 330214004460 putative substrate translocation pore; other site 330214004461 H+ Antiporter protein; Region: 2A0121; TIGR00900 330214004462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214004463 putative substrate translocation pore; other site 330214004464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 330214004465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 330214004466 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 330214004467 Protein of unknown function (DUF421); Region: DUF421; cl00990 330214004468 PilZ domain; Region: PilZ; pfam07238 330214004469 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 330214004470 recombinase A; Provisional; Region: recA; PRK09354 330214004471 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 330214004472 hexamer interface [polypeptide binding]; other site 330214004473 Walker A motif; other site 330214004474 ATP binding site [chemical binding]; other site 330214004475 Walker B motif; other site 330214004476 recombination regulator RecX; Reviewed; Region: recX; PRK00117 330214004477 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 330214004478 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 330214004479 motif 1; other site 330214004480 active site 330214004481 motif 2; other site 330214004482 motif 3; other site 330214004483 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 330214004484 DHHA1 domain; Region: DHHA1; pfam02272 330214004485 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 330214004486 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 330214004487 YceG-like family; Region: YceG; pfam02618 330214004488 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 330214004489 dimerization interface [polypeptide binding]; other site 330214004490 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 330214004491 intersubunit interface [polypeptide binding]; other site 330214004492 active site 330214004493 catalytic residue [active] 330214004494 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 330214004495 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 330214004496 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 330214004497 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 330214004498 RHS Repeat; Region: RHS_repeat; pfam05593 330214004499 RHS Repeat; Region: RHS_repeat; pfam05593 330214004500 RHS Repeat; Region: RHS_repeat; cl11982 330214004501 RHS Repeat; Region: RHS_repeat; pfam05593 330214004502 RHS Repeat; Region: RHS_repeat; pfam05593 330214004503 RHS Repeat; Region: RHS_repeat; pfam05593 330214004504 RHS Repeat; Region: RHS_repeat; pfam05593 330214004505 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 330214004506 calcium mediated ligand binding site; other site 330214004507 intermolecular salt bridges; other site 330214004508 RHS Repeat; Region: RHS_repeat; pfam05593 330214004509 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 330214004510 RHS Repeat; Region: RHS_repeat; cl11982 330214004511 RHS Repeat; Region: RHS_repeat; pfam05593 330214004512 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 330214004513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214004514 non-specific DNA binding site [nucleotide binding]; other site 330214004515 salt bridge; other site 330214004516 sequence-specific DNA binding site [nucleotide binding]; other site 330214004517 Putative methyltransferase; Region: Methyltransf_4; cl17290 330214004518 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 330214004519 homotrimer interaction site [polypeptide binding]; other site 330214004520 putative active site [active] 330214004521 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 330214004522 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 330214004523 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 330214004524 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 330214004525 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 330214004526 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 330214004527 RNA methyltransferase, RsmE family; Region: TIGR00046 330214004528 chaperone protein DnaJ; Provisional; Region: PRK10767 330214004529 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 330214004530 HSP70 interaction site [polypeptide binding]; other site 330214004531 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 330214004532 substrate binding site [polypeptide binding]; other site 330214004533 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 330214004534 Zn binding sites [ion binding]; other site 330214004535 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 330214004536 dimer interface [polypeptide binding]; other site 330214004537 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 330214004538 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 330214004539 nucleotide binding site [chemical binding]; other site 330214004540 NEF interaction site [polypeptide binding]; other site 330214004541 SBD interface [polypeptide binding]; other site 330214004542 GrpE; Region: GrpE; pfam01025 330214004543 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 330214004544 dimer interface [polypeptide binding]; other site 330214004545 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 330214004546 pantothenate kinase; Reviewed; Region: PRK13318 330214004547 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 330214004548 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 330214004549 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 330214004550 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 330214004551 dimerization interface [polypeptide binding]; other site 330214004552 active site 330214004553 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 330214004554 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 330214004555 HIGH motif; other site 330214004556 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 330214004557 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 330214004558 active site 330214004559 KMSKS motif; other site 330214004560 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 330214004561 tRNA binding surface [nucleotide binding]; other site 330214004562 anticodon binding site; other site 330214004563 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 330214004564 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214004565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004566 active site 330214004567 phosphorylation site [posttranslational modification] 330214004568 intermolecular recognition site; other site 330214004569 dimerization interface [polypeptide binding]; other site 330214004570 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 330214004571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214004572 motif II; other site 330214004573 NAD-dependent deacetylase; Provisional; Region: PRK00481 330214004574 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 330214004575 NAD+ binding site [chemical binding]; other site 330214004576 substrate binding site [chemical binding]; other site 330214004577 Zn binding site [ion binding]; other site 330214004578 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 330214004579 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 330214004580 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 330214004581 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 330214004582 Moco binding site; other site 330214004583 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 330214004584 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 330214004585 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 330214004586 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 330214004587 acyl-CoA synthetase; Validated; Region: PRK05850 330214004588 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 330214004589 acyl-activating enzyme (AAE) consensus motif; other site 330214004590 active site 330214004591 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 330214004592 Condensation domain; Region: Condensation; pfam00668 330214004593 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214004594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214004595 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214004596 acyl-activating enzyme (AAE) consensus motif; other site 330214004597 AMP binding site [chemical binding]; other site 330214004598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214004599 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 330214004600 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214004601 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 330214004602 acyl-activating enzyme (AAE) consensus motif; other site 330214004603 AMP binding site [chemical binding]; other site 330214004604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214004605 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 330214004606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214004607 Walker A/P-loop; other site 330214004608 ATP binding site [chemical binding]; other site 330214004609 Q-loop/lid; other site 330214004610 ABC transporter signature motif; other site 330214004611 Walker B; other site 330214004612 D-loop; other site 330214004613 H-loop/switch region; other site 330214004614 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 330214004615 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 330214004616 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 330214004617 nucleoside/Zn binding site; other site 330214004618 dimer interface [polypeptide binding]; other site 330214004619 catalytic motif [active] 330214004620 Putative zinc-finger; Region: zf-HC2; pfam13490 330214004621 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 330214004622 homodimer interface [polypeptide binding]; other site 330214004623 putative GKAP docking site [polypeptide binding]; other site 330214004624 Anti-sigma-K factor rskA; Region: RskA; pfam10099 330214004625 RNA polymerase sigma factor; Provisional; Region: PRK12519 330214004626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214004627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214004628 DNA binding residues [nucleotide binding] 330214004629 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 330214004630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004631 TPR motif; other site 330214004632 binding surface 330214004633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004634 binding surface 330214004635 TPR motif; other site 330214004636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214004639 binding surface 330214004640 TPR motif; other site 330214004641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214004642 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 330214004643 putative catalytic residue [active] 330214004644 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 330214004645 putative catalytic site [active] 330214004646 putative metal binding site [ion binding]; other site 330214004647 putative phosphate binding site [ion binding]; other site 330214004648 HDOD domain; Region: HDOD; pfam08668 330214004649 CCC1; Region: CCC1; cd02435 330214004650 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 330214004651 putative FMN binding site [chemical binding]; other site 330214004652 NADPH bind site [chemical binding]; other site 330214004653 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 330214004654 putative FMN binding site [chemical binding]; other site 330214004655 NADPH bind site [chemical binding]; other site 330214004656 VanZ like family; Region: VanZ; cl01971 330214004657 Response regulator receiver domain; Region: Response_reg; pfam00072 330214004658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004659 active site 330214004660 phosphorylation site [posttranslational modification] 330214004661 intermolecular recognition site; other site 330214004662 dimerization interface [polypeptide binding]; other site 330214004663 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 330214004664 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214004665 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 330214004666 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214004667 Outer membrane efflux protein; Region: OEP; pfam02321 330214004668 Outer membrane efflux protein; Region: OEP; pfam02321 330214004669 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 330214004670 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214004671 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 330214004672 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 330214004673 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 330214004674 Nitrogen regulatory protein P-II; Region: P-II; cl00412 330214004675 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214004676 GAF domain; Region: GAF; pfam01590 330214004677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004678 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214004679 putative active site [active] 330214004680 heme pocket [chemical binding]; other site 330214004681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214004682 dimer interface [polypeptide binding]; other site 330214004683 phosphorylation site [posttranslational modification] 330214004684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214004685 ATP binding site [chemical binding]; other site 330214004686 Mg2+ binding site [ion binding]; other site 330214004687 G-X-G motif; other site 330214004688 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214004689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004690 active site 330214004691 phosphorylation site [posttranslational modification] 330214004692 intermolecular recognition site; other site 330214004693 dimerization interface [polypeptide binding]; other site 330214004694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214004695 Walker A motif; other site 330214004696 ATP binding site [chemical binding]; other site 330214004697 Walker B motif; other site 330214004698 arginine finger; other site 330214004699 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214004700 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 330214004701 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 330214004702 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 330214004703 putative transposase OrfB; Reviewed; Region: PHA02517 330214004704 HTH-like domain; Region: HTH_21; pfam13276 330214004705 Integrase core domain; Region: rve; pfam00665 330214004706 Integrase core domain; Region: rve_3; pfam13683 330214004707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214004708 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214004709 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 330214004710 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 330214004711 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 330214004712 DEAD-like helicases superfamily; Region: DEXDc; smart00487 330214004713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214004714 ATP binding site [chemical binding]; other site 330214004715 putative Mg++ binding site [ion binding]; other site 330214004716 helicase superfamily c-terminal domain; Region: HELICc; smart00490 330214004717 nucleotide binding region [chemical binding]; other site 330214004718 ATP-binding site [chemical binding]; other site 330214004719 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 330214004720 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 330214004721 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 330214004722 ligand binding site; other site 330214004723 oligomer interface; other site 330214004724 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 330214004725 dimer interface [polypeptide binding]; other site 330214004726 N-terminal domain interface [polypeptide binding]; other site 330214004727 sulfate 1 binding site; other site 330214004728 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 330214004729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214004730 Walker A/P-loop; other site 330214004731 ATP binding site [chemical binding]; other site 330214004732 Q-loop/lid; other site 330214004733 ABC transporter signature motif; other site 330214004734 Walker B; other site 330214004735 D-loop; other site 330214004736 H-loop/switch region; other site 330214004737 TOBE domain; Region: TOBE_2; pfam08402 330214004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214004739 dimer interface [polypeptide binding]; other site 330214004740 conserved gate region; other site 330214004741 putative PBP binding loops; other site 330214004742 ABC-ATPase subunit interface; other site 330214004743 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 330214004744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214004745 dimer interface [polypeptide binding]; other site 330214004746 conserved gate region; other site 330214004747 putative PBP binding loops; other site 330214004748 ABC-ATPase subunit interface; other site 330214004749 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 330214004750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 330214004751 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 330214004752 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 330214004753 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214004754 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214004755 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214004756 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 330214004757 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 330214004758 HEAT repeats; Region: HEAT_2; pfam13646 330214004759 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 330214004760 active site 330214004761 catalytic residues [active] 330214004762 metal binding site [ion binding]; metal-binding site 330214004763 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 330214004764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 330214004765 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 330214004766 Walker A/P-loop; other site 330214004767 ATP binding site [chemical binding]; other site 330214004768 Q-loop/lid; other site 330214004769 ABC transporter signature motif; other site 330214004770 Walker B; other site 330214004771 D-loop; other site 330214004772 H-loop/switch region; other site 330214004773 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 330214004774 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 330214004775 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 330214004776 putative active site pocket [active] 330214004777 dimerization interface [polypeptide binding]; other site 330214004778 putative catalytic residue [active] 330214004779 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 330214004780 MPN+ (JAMM) motif; other site 330214004781 Zinc-binding site [ion binding]; other site 330214004782 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 330214004783 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 330214004784 ATP binding site [chemical binding]; other site 330214004785 substrate interface [chemical binding]; other site 330214004786 NIL domain; Region: NIL; pfam09383 330214004787 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 330214004788 MoaE interaction surface [polypeptide binding]; other site 330214004789 MoeB interaction surface [polypeptide binding]; other site 330214004790 thiocarboxylated glycine; other site 330214004791 threonine synthase; Validated; Region: PRK07591 330214004792 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 330214004793 homodimer interface [polypeptide binding]; other site 330214004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214004795 catalytic residue [active] 330214004796 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 330214004797 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 330214004798 ATP binding site [chemical binding]; other site 330214004799 substrate interface [chemical binding]; other site 330214004800 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 330214004801 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 330214004802 dimer interface [polypeptide binding]; other site 330214004803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214004804 catalytic residue [active] 330214004805 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 330214004806 thiS-thiF/thiG interaction site; other site 330214004807 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 330214004808 PLD-like domain; Region: PLDc_2; pfam13091 330214004809 putative active site [active] 330214004810 catalytic site [active] 330214004811 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 330214004812 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 330214004813 Repair protein; Region: Repair_PSII; pfam04536 330214004814 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 330214004815 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 330214004816 Integrase core domain; Region: rve_3; cl15866 330214004817 Transposase; Region: DEDD_Tnp_IS110; pfam01548 330214004818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 330214004819 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 330214004820 SnoaL-like domain; Region: SnoaL_2; pfam12680 330214004821 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214004822 Ligand Binding Site [chemical binding]; other site 330214004823 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214004824 Ligand Binding Site [chemical binding]; other site 330214004825 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 330214004826 FOG: CBS domain [General function prediction only]; Region: COG0517 330214004827 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 330214004828 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 330214004829 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214004830 Ligand Binding Site [chemical binding]; other site 330214004831 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 330214004832 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 330214004833 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 330214004834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214004835 FeS/SAM binding site; other site 330214004836 HemN C-terminal domain; Region: HemN_C; pfam06969 330214004837 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 330214004838 Response regulator receiver domain; Region: Response_reg; pfam00072 330214004839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004840 active site 330214004841 phosphorylation site [posttranslational modification] 330214004842 intermolecular recognition site; other site 330214004843 dimerization interface [polypeptide binding]; other site 330214004844 Response regulator receiver domain; Region: Response_reg; pfam00072 330214004845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004846 active site 330214004847 phosphorylation site [posttranslational modification] 330214004848 intermolecular recognition site; other site 330214004849 dimerization interface [polypeptide binding]; other site 330214004850 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214004851 putative binding surface; other site 330214004852 active site 330214004853 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214004854 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214004855 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 330214004856 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 330214004857 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 330214004858 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 330214004859 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 330214004860 substrate binding pocket [chemical binding]; other site 330214004861 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 330214004862 B12 binding site [chemical binding]; other site 330214004863 cobalt ligand [ion binding]; other site 330214004864 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 330214004865 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 330214004866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004867 active site 330214004868 phosphorylation site [posttranslational modification] 330214004869 intermolecular recognition site; other site 330214004870 dimerization interface [polypeptide binding]; other site 330214004871 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214004872 Zn2+ binding site [ion binding]; other site 330214004873 Mg2+ binding site [ion binding]; other site 330214004874 ribonuclease PH; Reviewed; Region: rph; PRK00173 330214004875 Ribonuclease PH; Region: RNase_PH_bact; cd11362 330214004876 hexamer interface [polypeptide binding]; other site 330214004877 active site 330214004878 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 330214004879 active site 330214004880 dimerization interface [polypeptide binding]; other site 330214004881 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 330214004882 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 330214004883 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 330214004884 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 330214004885 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214004886 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 330214004887 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 330214004888 dimer interface [polypeptide binding]; other site 330214004889 decamer (pentamer of dimers) interface [polypeptide binding]; other site 330214004890 catalytic triad [active] 330214004891 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 330214004892 B12 binding site [chemical binding]; other site 330214004893 Radical SAM superfamily; Region: Radical_SAM; pfam04055 330214004894 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 330214004895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214004896 Zn2+ binding site [ion binding]; other site 330214004897 Mg2+ binding site [ion binding]; other site 330214004898 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 330214004899 dimer interface [polypeptide binding]; other site 330214004900 catalytic residue [active] 330214004901 metal binding site [ion binding]; metal-binding site 330214004902 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 330214004903 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 330214004904 catalytic residues [active] 330214004905 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214004906 methionine sulfoxide reductase B; Provisional; Region: PRK00222 330214004907 SelR domain; Region: SelR; pfam01641 330214004908 Found in ATP-dependent protease La (LON); Region: LON; smart00464 330214004909 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 330214004910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214004911 Walker A motif; other site 330214004912 ATP binding site [chemical binding]; other site 330214004913 Walker B motif; other site 330214004914 arginine finger; other site 330214004915 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 330214004916 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 330214004917 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 330214004918 active site 330214004919 homotetramer interface [polypeptide binding]; other site 330214004920 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 330214004921 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 330214004922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 330214004923 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 330214004924 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 330214004925 nudix motif; other site 330214004926 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 330214004927 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 330214004928 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 330214004929 HsdM N-terminal domain; Region: HsdM_N; pfam12161 330214004930 Methyltransferase domain; Region: Methyltransf_26; pfam13659 330214004931 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 330214004932 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 330214004933 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 330214004934 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 330214004935 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 330214004936 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 330214004937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214004938 ATP binding site [chemical binding]; other site 330214004939 putative Mg++ binding site [ion binding]; other site 330214004940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214004941 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 330214004942 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 330214004943 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 330214004944 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 330214004945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 330214004946 active site 330214004947 metal binding site [ion binding]; metal-binding site 330214004948 DNA binding site [nucleotide binding] 330214004949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214004950 AAA domain; Region: AAA_27; pfam13514 330214004951 Walker A/P-loop; other site 330214004952 ATP binding site [chemical binding]; other site 330214004953 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214004954 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214004955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004956 putative active site [active] 330214004957 heme pocket [chemical binding]; other site 330214004958 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214004959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214004960 putative active site [active] 330214004961 heme pocket [chemical binding]; other site 330214004962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214004963 dimer interface [polypeptide binding]; other site 330214004964 phosphorylation site [posttranslational modification] 330214004965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214004966 ATP binding site [chemical binding]; other site 330214004967 Mg2+ binding site [ion binding]; other site 330214004968 G-X-G motif; other site 330214004969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 330214004970 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214004971 active site 330214004972 phosphorylation site [posttranslational modification] 330214004973 intermolecular recognition site; other site 330214004974 dimerization interface [polypeptide binding]; other site 330214004975 Response regulator receiver domain; Region: Response_reg; pfam00072 330214004976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214004977 active site 330214004978 phosphorylation site [posttranslational modification] 330214004979 intermolecular recognition site; other site 330214004980 dimerization interface [polypeptide binding]; other site 330214004981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 330214004982 classical (c) SDRs; Region: SDR_c; cd05233 330214004983 NAD(P) binding site [chemical binding]; other site 330214004984 active site 330214004985 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 330214004986 PilZ domain; Region: PilZ; pfam07238 330214004987 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 330214004988 endonuclease III; Region: ENDO3c; smart00478 330214004989 minor groove reading motif; other site 330214004990 helix-hairpin-helix signature motif; other site 330214004991 substrate binding pocket [chemical binding]; other site 330214004992 active site 330214004993 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 330214004994 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 330214004995 active site 330214004996 8-oxo-dGMP binding site [chemical binding]; other site 330214004997 nudix motif; other site 330214004998 metal binding site [ion binding]; metal-binding site 330214004999 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 330214005000 active site 330214005001 catalytic site [active] 330214005002 substrate binding site [chemical binding]; other site 330214005003 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 330214005004 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 330214005005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214005006 FeS/SAM binding site; other site 330214005007 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 330214005008 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 330214005009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214005010 FeS/SAM binding site; other site 330214005011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214005012 Ligand Binding Site [chemical binding]; other site 330214005013 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214005014 Ligand Binding Site [chemical binding]; other site 330214005015 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 330214005016 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214005017 Ligand Binding Site [chemical binding]; other site 330214005018 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 330214005019 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214005020 Ligand Binding Site [chemical binding]; other site 330214005021 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214005022 Ligand Binding Site [chemical binding]; other site 330214005023 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 330214005024 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 330214005025 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 330214005026 putative dimer interface [polypeptide binding]; other site 330214005027 [2Fe-2S] cluster binding site [ion binding]; other site 330214005028 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214005029 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 330214005030 SLBB domain; Region: SLBB; pfam10531 330214005031 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 330214005032 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 330214005033 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 330214005034 catalytic loop [active] 330214005035 iron binding site [ion binding]; other site 330214005036 4Fe-4S binding domain; Region: Fer4; pfam00037 330214005037 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 330214005038 [4Fe-4S] binding site [ion binding]; other site 330214005039 molybdopterin cofactor binding site; other site 330214005040 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 330214005041 molybdopterin cofactor binding site; other site 330214005042 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 330214005043 muropeptide transporter; Reviewed; Region: ampG; PRK11902 330214005044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214005045 putative substrate translocation pore; other site 330214005046 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 330214005047 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 330214005048 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 330214005049 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 330214005050 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 330214005051 active site 330214005052 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 330214005053 TSCPD domain; Region: TSCPD; pfam12637 330214005054 Caspase domain; Region: Peptidase_C14; pfam00656 330214005055 Cna protein B-type domain; Region: Cna_B_2; pfam13715 330214005056 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 330214005057 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 330214005058 haemagglutination activity domain; Region: Haemagg_act; pfam05860 330214005059 haemagglutination activity domain; Region: Haemagg_act; pfam05860 330214005060 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 330214005061 haemagglutination activity domain; Region: Haemagg_act; pfam05860 330214005062 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 330214005063 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 330214005064 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214005065 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 330214005066 ligand binding site [chemical binding]; other site 330214005067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005068 binding surface 330214005069 TPR motif; other site 330214005070 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005071 CHAT domain; Region: CHAT; cl17868 330214005072 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 330214005073 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 330214005074 cyclase homology domain; Region: CHD; cd07302 330214005075 nucleotidyl binding site; other site 330214005076 metal binding site [ion binding]; metal-binding site 330214005077 dimer interface [polypeptide binding]; other site 330214005078 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 330214005079 phosphopeptide binding site; other site 330214005080 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 330214005081 active site 330214005082 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 330214005083 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 330214005084 structural tetrad; other site 330214005085 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 330214005086 FecR protein; Region: FecR; pfam04773 330214005087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005088 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005090 binding surface 330214005091 TPR motif; other site 330214005092 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005094 binding surface 330214005095 TPR motif; other site 330214005096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005097 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005099 TPR motif; other site 330214005100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005101 binding surface 330214005102 CHAT domain; Region: CHAT; pfam12770 330214005103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005104 binding surface 330214005105 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214005106 TPR motif; other site 330214005107 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214005108 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214005109 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 330214005110 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 330214005111 phosphopeptide binding site; other site 330214005112 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 330214005113 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 330214005114 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 330214005115 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 330214005116 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 330214005117 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 330214005118 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 330214005119 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 330214005120 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 330214005121 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 330214005122 ImpE protein; Region: ImpE; pfam07024 330214005123 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 330214005124 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 330214005125 Protein of unknown function (DUF770); Region: DUF770; pfam05591 330214005126 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 330214005127 Protein of unknown function (DUF877); Region: DUF877; pfam05943 330214005128 Protein of unknown function (DUF796); Region: DUF796; pfam05638 330214005129 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 330214005130 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 330214005131 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 330214005132 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 330214005133 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 330214005134 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 330214005135 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 330214005136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005137 Walker A motif; other site 330214005138 ATP binding site [chemical binding]; other site 330214005139 Walker B motif; other site 330214005140 arginine finger; other site 330214005141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005142 Walker A motif; other site 330214005143 ATP binding site [chemical binding]; other site 330214005144 Walker B motif; other site 330214005145 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 330214005146 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 330214005147 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 330214005148 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 330214005149 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 330214005150 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 330214005151 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 330214005152 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 330214005153 conserved hypothetical protein; Region: TIGR02270 330214005154 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 330214005155 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 330214005156 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 330214005157 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 330214005158 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214005159 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214005160 ligand binding site [chemical binding]; other site 330214005161 conserved hypothetical protein; Region: TIGR02270 330214005162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 330214005163 Integrase core domain; Region: rve; pfam00665 330214005164 transposase; Provisional; Region: PRK06526 330214005165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005166 Walker A motif; other site 330214005167 ATP binding site [chemical binding]; other site 330214005168 Walker B motif; other site 330214005169 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 330214005170 conserved hypothetical protein; Region: TIGR02270 330214005171 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 330214005172 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 330214005173 Autotransporter beta-domain; Region: Autotransporter; smart00869 330214005174 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 330214005175 Sel1-like repeats; Region: SEL1; smart00671 330214005176 Sel1-like repeats; Region: SEL1; smart00671 330214005177 Caspase domain; Region: Peptidase_C14; pfam00656 330214005178 Protein of unknown function (DUF770); Region: DUF770; cl01402 330214005179 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 330214005180 Protein of unknown function (DUF877); Region: DUF877; pfam05943 330214005181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 330214005182 Transposase; Region: HTH_Tnp_1; cl17663 330214005183 putative transposase OrfB; Reviewed; Region: PHA02517 330214005184 HTH-like domain; Region: HTH_21; pfam13276 330214005185 Integrase core domain; Region: rve; pfam00665 330214005186 Integrase core domain; Region: rve_3; pfam13683 330214005187 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 330214005188 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 330214005189 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214005190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005191 active site 330214005192 phosphorylation site [posttranslational modification] 330214005193 intermolecular recognition site; other site 330214005194 dimerization interface [polypeptide binding]; other site 330214005195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005196 Walker A motif; other site 330214005197 ATP binding site [chemical binding]; other site 330214005198 Walker B motif; other site 330214005199 arginine finger; other site 330214005200 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214005201 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214005202 GAF domain; Region: GAF; pfam01590 330214005203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214005204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214005205 ATP binding site [chemical binding]; other site 330214005206 Mg2+ binding site [ion binding]; other site 330214005207 G-X-G motif; other site 330214005208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 330214005209 Catalytic domain of Protein Kinases; Region: PKc; cd00180 330214005210 active site 330214005211 ATP binding site [chemical binding]; other site 330214005212 substrate binding site [chemical binding]; other site 330214005213 activation loop (A-loop); other site 330214005214 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 330214005215 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 330214005216 phosphopeptide binding site; other site 330214005217 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 330214005218 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214005219 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214005220 catalytic residue [active] 330214005221 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 330214005222 Catalytic domain of Protein Kinases; Region: PKc; cd00180 330214005223 active site 330214005224 ATP binding site [chemical binding]; other site 330214005225 substrate binding site [chemical binding]; other site 330214005226 activation loop (A-loop); other site 330214005227 LPP20 lipoprotein; Region: LPP20; pfam02169 330214005228 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 330214005229 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 330214005230 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 330214005231 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214005232 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 330214005233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214005234 binding surface 330214005235 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005236 TPR motif; other site 330214005237 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214005238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214005239 binding surface 330214005240 TPR motif; other site 330214005241 CHAT domain; Region: CHAT; cl17868 330214005242 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 330214005243 Cupin domain; Region: Cupin_2; pfam07883 330214005244 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 330214005245 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 330214005246 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 330214005247 Sporulation related domain; Region: SPOR; pfam05036 330214005248 Domain of unknown function DUF21; Region: DUF21; pfam01595 330214005249 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 330214005250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 330214005251 Transporter associated domain; Region: CorC_HlyC; smart01091 330214005252 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 330214005253 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 330214005254 nucleotide binding pocket [chemical binding]; other site 330214005255 K-X-D-G motif; other site 330214005256 catalytic site [active] 330214005257 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 330214005258 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 330214005259 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 330214005260 Dimer interface [polypeptide binding]; other site 330214005261 BRCT sequence motif; other site 330214005262 MoxR-like ATPases [General function prediction only]; Region: COG0714 330214005263 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 330214005264 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 330214005265 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 330214005266 anthranilate synthase component I; Provisional; Region: PRK13565 330214005267 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 330214005268 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 330214005269 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 330214005270 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 330214005271 glutamine binding [chemical binding]; other site 330214005272 catalytic triad [active] 330214005273 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 330214005274 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 330214005275 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 330214005276 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 330214005277 active site 330214005278 ribulose/triose binding site [chemical binding]; other site 330214005279 phosphate binding site [ion binding]; other site 330214005280 substrate (anthranilate) binding pocket [chemical binding]; other site 330214005281 product (indole) binding pocket [chemical binding]; other site 330214005282 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 330214005283 active site 330214005284 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 330214005285 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 330214005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214005287 catalytic residue [active] 330214005288 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 330214005289 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 330214005290 substrate binding site [chemical binding]; other site 330214005291 active site 330214005292 catalytic residues [active] 330214005293 heterodimer interface [polypeptide binding]; other site 330214005294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214005295 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214005296 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 330214005297 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 330214005298 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 330214005299 Walker A/P-loop; other site 330214005300 ATP binding site [chemical binding]; other site 330214005301 Q-loop/lid; other site 330214005302 ABC transporter signature motif; other site 330214005303 Walker B; other site 330214005304 D-loop; other site 330214005305 H-loop/switch region; other site 330214005306 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 330214005307 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214005308 FtsX-like permease family; Region: FtsX; pfam02687 330214005309 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 330214005310 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 330214005311 dimer interface [polypeptide binding]; other site 330214005312 putative anticodon binding site; other site 330214005313 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 330214005314 motif 1; other site 330214005315 active site 330214005316 motif 2; other site 330214005317 motif 3; other site 330214005318 peptide chain release factor 2; Validated; Region: prfB; PRK00578 330214005319 This domain is found in peptide chain release factors; Region: PCRF; smart00937 330214005320 RF-1 domain; Region: RF-1; pfam00472 330214005321 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 330214005322 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 330214005323 putative active site [active] 330214005324 catalytic triad [active] 330214005325 putative dimer interface [polypeptide binding]; other site 330214005326 PilZ domain; Region: PilZ; pfam07238 330214005327 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 330214005328 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 330214005329 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 330214005330 Dodecin; Region: Dodecin; pfam07311 330214005331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214005332 Walker A/P-loop; other site 330214005333 ATP binding site [chemical binding]; other site 330214005334 Response regulator receiver domain; Region: Response_reg; pfam00072 330214005335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005336 active site 330214005337 phosphorylation site [posttranslational modification] 330214005338 intermolecular recognition site; other site 330214005339 dimerization interface [polypeptide binding]; other site 330214005340 PAS domain S-box; Region: sensory_box; TIGR00229 330214005341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214005342 putative active site [active] 330214005343 heme pocket [chemical binding]; other site 330214005344 PAS fold; Region: PAS_4; pfam08448 330214005345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214005346 putative active site [active] 330214005347 heme pocket [chemical binding]; other site 330214005348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214005349 putative active site [active] 330214005350 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 330214005351 DNA topoisomerase VI subunit B; Validated; Region: PRK04184 330214005352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214005353 ATP binding site [chemical binding]; other site 330214005354 Mg2+ binding site [ion binding]; other site 330214005355 G-X-G motif; other site 330214005356 TopoIIB_Trans: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIB family of DNA topoisomerases similar to Sulfolobus shibatae topoisomerase VI (topoVI). The sole representative of the Type IIB...; Region: TopoIIB_Trans; cd00823 330214005357 anchoring element; other site 330214005358 dimer interface [polypeptide binding]; other site 330214005359 ATP binding site [chemical binding]; other site 330214005360 DNA topoisomerase VI subunit A; Provisional; Region: PRK04342 330214005361 Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406 330214005362 TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223 330214005363 active site 330214005364 metal binding site [ion binding]; metal-binding site 330214005365 interdomain interaction site; other site 330214005366 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 330214005367 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 330214005368 phosphoglucomutase; Validated; Region: PRK07564 330214005369 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 330214005370 active site 330214005371 substrate binding site [chemical binding]; other site 330214005372 metal binding site [ion binding]; metal-binding site 330214005373 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214005374 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 330214005375 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 330214005376 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 330214005377 Family description; Region: UvrD_C_2; pfam13538 330214005378 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 330214005379 TPR repeat; Region: TPR_11; pfam13414 330214005380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005381 binding surface 330214005382 TPR motif; other site 330214005383 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 330214005384 YtxH-like protein; Region: YtxH; pfam12732 330214005385 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 330214005386 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 330214005387 putative active site [active] 330214005388 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 330214005389 putative active site [active] 330214005390 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 330214005391 dimer interface [polypeptide binding]; other site 330214005392 [2Fe-2S] cluster binding site [ion binding]; other site 330214005393 Protein of unknown function (DUF3209); Region: DUF3209; pfam11483 330214005394 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 330214005395 FAD binding pocket [chemical binding]; other site 330214005396 conserved FAD binding motif [chemical binding]; other site 330214005397 phosphate binding motif [ion binding]; other site 330214005398 beta-alpha-beta structure motif; other site 330214005399 NAD binding pocket [chemical binding]; other site 330214005400 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 330214005401 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 330214005402 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 330214005403 Precorrin-8X methylmutase; Region: CbiC; pfam02570 330214005404 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 330214005405 active site 330214005406 putative homodimer interface [polypeptide binding]; other site 330214005407 SAM binding site [chemical binding]; other site 330214005408 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 330214005409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214005410 S-adenosylmethionine binding site [chemical binding]; other site 330214005411 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 330214005412 active site 330214005413 SAM binding site [chemical binding]; other site 330214005414 homodimer interface [polypeptide binding]; other site 330214005415 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 330214005416 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 330214005417 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 330214005418 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 330214005419 active site 330214005420 SAM binding site [chemical binding]; other site 330214005421 homodimer interface [polypeptide binding]; other site 330214005422 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 330214005423 active site 330214005424 SAM binding site [chemical binding]; other site 330214005425 homodimer interface [polypeptide binding]; other site 330214005426 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 330214005427 active site 330214005428 SAM binding site [chemical binding]; other site 330214005429 homodimer interface [polypeptide binding]; other site 330214005430 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 330214005431 active site 330214005432 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 330214005433 putative FMN binding site [chemical binding]; other site 330214005434 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 330214005435 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 330214005436 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 330214005437 catalytic triad [active] 330214005438 High-affinity nickel-transport protein; Region: NicO; cl00964 330214005439 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 330214005440 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 330214005441 TPR repeat; Region: TPR_11; pfam13414 330214005442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005443 binding surface 330214005444 TPR motif; other site 330214005445 TPR repeat; Region: TPR_11; pfam13414 330214005446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005447 binding surface 330214005448 TPR motif; other site 330214005449 TPR repeat; Region: TPR_11; pfam13414 330214005450 TPR repeat; Region: TPR_11; pfam13414 330214005451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214005452 binding surface 330214005453 TPR motif; other site 330214005454 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 330214005455 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 330214005456 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 330214005457 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 330214005458 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 330214005459 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 330214005460 ATP binding site [chemical binding]; other site 330214005461 Walker A motif; other site 330214005462 hexamer interface [polypeptide binding]; other site 330214005463 Walker B motif; other site 330214005464 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 330214005465 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 330214005466 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214005467 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 330214005468 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 330214005469 BON domain; Region: BON; pfam04972 330214005470 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 330214005471 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 330214005472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005473 active site 330214005474 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 330214005475 phosphorylation site [posttranslational modification] 330214005476 intermolecular recognition site; other site 330214005477 dimerization interface [polypeptide binding]; other site 330214005478 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 330214005479 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 330214005480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214005481 ATP binding site [chemical binding]; other site 330214005482 Mg2+ binding site [ion binding]; other site 330214005483 G-X-G motif; other site 330214005484 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 330214005485 anti sigma factor interaction site; other site 330214005486 regulatory phosphorylation site [posttranslational modification]; other site 330214005487 Transposase; Region: HTH_Tnp_1; cl17663 330214005488 putative transposase OrfB; Reviewed; Region: PHA02517 330214005489 HTH-like domain; Region: HTH_21; pfam13276 330214005490 Integrase core domain; Region: rve; pfam00665 330214005491 Integrase core domain; Region: rve_3; pfam13683 330214005492 Helix-turn-helix domain; Region: HTH_28; pfam13518 330214005493 Winged helix-turn helix; Region: HTH_29; pfam13551 330214005494 Integrase core domain; Region: rve; pfam00665 330214005495 Integrase core domain; Region: rve_3; pfam13683 330214005496 FOG: CBS domain [General function prediction only]; Region: COG0517 330214005497 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214005498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 330214005499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 330214005500 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 330214005501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214005502 NAD(P) binding site [chemical binding]; other site 330214005503 active site 330214005504 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 330214005505 Uncharacterized conserved protein [Function unknown]; Region: COG2128 330214005506 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 330214005507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 330214005508 classical (c) SDRs; Region: SDR_c; cd05233 330214005509 NAD(P) binding site [chemical binding]; other site 330214005510 active site 330214005511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 330214005512 HTH-like domain; Region: HTH_21; pfam13276 330214005513 Integrase core domain; Region: rve; pfam00665 330214005514 Integrase core domain; Region: rve_3; pfam13683 330214005515 Transposase; Region: HTH_Tnp_1; pfam01527 330214005516 Integrase core domain; Region: rve_3; cl15866 330214005517 Integrase core domain; Region: rve; pfam00665 330214005518 Transposase; Region: DEDD_Tnp_IS110; pfam01548 330214005519 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 330214005520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 330214005521 Integrase core domain; Region: rve; pfam00665 330214005522 transposase; Provisional; Region: PRK06526 330214005523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005524 Walker A motif; other site 330214005525 ATP binding site [chemical binding]; other site 330214005526 Walker B motif; other site 330214005527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 330214005528 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 330214005529 Winged helix-turn helix; Region: HTH_29; pfam13551 330214005530 Homeodomain-like domain; Region: HTH_23; pfam13384 330214005531 Integrase core domain; Region: rve; pfam00665 330214005532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214005533 non-specific DNA binding site [nucleotide binding]; other site 330214005534 salt bridge; other site 330214005535 sequence-specific DNA binding site [nucleotide binding]; other site 330214005536 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 330214005537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214005538 non-specific DNA binding site [nucleotide binding]; other site 330214005539 salt bridge; other site 330214005540 sequence-specific DNA binding site [nucleotide binding]; other site 330214005541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214005542 DNA binding site [nucleotide binding] 330214005543 active site 330214005544 Int/Topo IB signature motif; other site 330214005545 HsdM N-terminal domain; Region: HsdM_N; pfam12161 330214005546 PilZ domain; Region: PilZ; pfam07238 330214005547 acyl-CoA synthetase; Validated; Region: PRK05850 330214005548 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 330214005549 acyl-activating enzyme (AAE) consensus motif; other site 330214005550 active site 330214005551 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005552 Condensation domain; Region: Condensation; pfam00668 330214005553 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005554 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214005555 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005556 acyl-activating enzyme (AAE) consensus motif; other site 330214005557 AMP binding site [chemical binding]; other site 330214005558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214005559 S-adenosylmethionine binding site [chemical binding]; other site 330214005560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 330214005561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005562 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 330214005563 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 330214005564 active site 330214005565 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 330214005566 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 330214005567 putative NADP binding site [chemical binding]; other site 330214005568 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 330214005569 active site 330214005570 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 330214005572 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 330214005573 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 330214005574 Walker A/P-loop; other site 330214005575 ATP binding site [chemical binding]; other site 330214005576 Q-loop/lid; other site 330214005577 ABC transporter signature motif; other site 330214005578 Walker B; other site 330214005579 D-loop; other site 330214005580 H-loop/switch region; other site 330214005581 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 330214005582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 330214005583 inhibitor-cofactor binding pocket; inhibition site 330214005584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214005585 catalytic residue [active] 330214005586 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 330214005587 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 330214005588 active site 330214005589 MbtH-like protein; Region: MbtH; cl01279 330214005590 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 330214005591 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 330214005592 nucleophilic elbow; other site 330214005593 catalytic triad; other site 330214005594 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 330214005595 Condensation domain; Region: Condensation; pfam00668 330214005596 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005597 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214005598 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005599 acyl-activating enzyme (AAE) consensus motif; other site 330214005600 AMP binding site [chemical binding]; other site 330214005601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005602 Condensation domain; Region: Condensation; pfam00668 330214005603 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005604 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005605 acyl-activating enzyme (AAE) consensus motif; other site 330214005606 AMP binding site [chemical binding]; other site 330214005607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005608 Condensation domain; Region: Condensation; pfam00668 330214005609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005610 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005611 acyl-activating enzyme (AAE) consensus motif; other site 330214005612 AMP binding site [chemical binding]; other site 330214005613 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005614 Condensation domain; Region: Condensation; pfam00668 330214005615 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005616 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214005617 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005618 acyl-activating enzyme (AAE) consensus motif; other site 330214005619 AMP binding site [chemical binding]; other site 330214005620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005621 Condensation domain; Region: Condensation; pfam00668 330214005622 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005623 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 330214005624 Condensation domain; Region: Condensation; pfam00668 330214005625 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005626 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005627 acyl-activating enzyme (AAE) consensus motif; other site 330214005628 AMP binding site [chemical binding]; other site 330214005629 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005630 Condensation domain; Region: Condensation; pfam00668 330214005631 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005632 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005633 acyl-activating enzyme (AAE) consensus motif; other site 330214005634 AMP binding site [chemical binding]; other site 330214005635 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005636 Condensation domain; Region: Condensation; pfam00668 330214005637 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005638 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214005639 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 330214005640 Condensation domain; Region: Condensation; pfam00668 330214005641 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005642 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 330214005643 acyl-activating enzyme (AAE) consensus motif; other site 330214005644 AMP binding site [chemical binding]; other site 330214005645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005646 Condensation domain; Region: Condensation; pfam00668 330214005647 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 330214005648 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 330214005649 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 330214005650 acyl-activating enzyme (AAE) consensus motif; other site 330214005651 AMP binding site [chemical binding]; other site 330214005652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214005653 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 330214005654 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 330214005655 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214005656 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214005657 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214005658 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 330214005659 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 330214005660 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 330214005661 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 330214005662 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 330214005663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 330214005664 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 330214005665 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 330214005666 Secretin and TonB N terminus short domain; Region: STN; smart00965 330214005667 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 330214005668 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214005669 N-terminal plug; other site 330214005670 ligand-binding site [chemical binding]; other site 330214005671 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 330214005672 FecR protein; Region: FecR; pfam04773 330214005673 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 330214005674 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214005675 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214005676 DNA binding residues [nucleotide binding] 330214005677 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 330214005678 metal binding site 2 [ion binding]; metal-binding site 330214005679 putative DNA binding helix; other site 330214005680 metal binding site 1 [ion binding]; metal-binding site 330214005681 dimer interface [polypeptide binding]; other site 330214005682 structural Zn2+ binding site [ion binding]; other site 330214005683 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 330214005684 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 330214005685 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 330214005686 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 330214005687 Secretin and TonB N terminus short domain; Region: STN; smart00965 330214005688 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 330214005689 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214005690 N-terminal plug; other site 330214005691 ligand-binding site [chemical binding]; other site 330214005692 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 330214005693 FecR protein; Region: FecR; pfam04773 330214005694 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 330214005695 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 330214005696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214005697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214005698 DNA binding residues [nucleotide binding] 330214005699 Secretin and TonB N terminus short domain; Region: STN; smart00965 330214005700 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 330214005701 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214005702 N-terminal plug; other site 330214005703 ligand-binding site [chemical binding]; other site 330214005704 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 330214005705 FecR protein; Region: FecR; pfam04773 330214005706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214005707 RNA polymerase sigma factor; Reviewed; Region: PRK12527 330214005708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214005709 DNA binding residues [nucleotide binding] 330214005710 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 330214005711 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 330214005712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 330214005713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 330214005714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 330214005715 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 330214005716 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 330214005717 seryl-tRNA synthetase; Provisional; Region: PRK05431 330214005718 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 330214005719 dimer interface [polypeptide binding]; other site 330214005720 active site 330214005721 motif 1; other site 330214005722 motif 2; other site 330214005723 motif 3; other site 330214005724 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 330214005725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214005726 FeS/SAM binding site; other site 330214005727 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 330214005728 active site residue [active] 330214005729 Uncharacterized conserved protein [Function unknown]; Region: COG2006 330214005730 Domain of unknown function (DUF362); Region: DUF362; pfam04015 330214005731 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 330214005732 periplasmic chaperone; Provisional; Region: PRK10780 330214005733 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 330214005734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214005735 Zn2+ binding site [ion binding]; other site 330214005736 Mg2+ binding site [ion binding]; other site 330214005737 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214005738 active site 330214005739 catalytic triad [active] 330214005740 oxyanion hole [active] 330214005741 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 330214005742 catalytic residues [active] 330214005743 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 330214005744 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 330214005745 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 330214005746 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 330214005747 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 330214005748 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 330214005749 active site 330214005750 NTP binding site [chemical binding]; other site 330214005751 metal binding triad [ion binding]; metal-binding site 330214005752 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 330214005753 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 330214005754 tetramer interface [polypeptide binding]; other site 330214005755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214005756 catalytic residue [active] 330214005757 TLC ATP/ADP transporter; Region: TLC; cl03940 330214005758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 330214005759 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 330214005760 NAD(P) binding site [chemical binding]; other site 330214005761 catalytic residues [active] 330214005762 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214005763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214005764 S-adenosylmethionine binding site [chemical binding]; other site 330214005765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214005766 active site 330214005767 PGAP1-like protein; Region: PGAP1; pfam07819 330214005768 CHAT domain; Region: CHAT; pfam12770 330214005769 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 330214005770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214005771 active site 330214005772 motif I; other site 330214005773 motif II; other site 330214005774 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 330214005775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005776 Walker A motif; other site 330214005777 ATP binding site [chemical binding]; other site 330214005778 Walker B motif; other site 330214005779 arginine finger; other site 330214005780 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 330214005781 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 330214005782 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 330214005783 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 330214005784 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 330214005785 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 330214005786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005787 Walker A motif; other site 330214005788 ATP binding site [chemical binding]; other site 330214005789 Walker B motif; other site 330214005790 arginine finger; other site 330214005791 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 330214005792 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 330214005793 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 330214005794 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 330214005795 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 330214005796 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 330214005797 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 330214005798 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 330214005799 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 330214005800 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 330214005801 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 330214005802 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 330214005803 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 330214005804 chromosome segregation protein; Provisional; Region: PRK02224 330214005805 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 330214005806 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 330214005807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214005808 Radical SAM superfamily; Region: Radical_SAM; pfam04055 330214005809 FeS/SAM binding site; other site 330214005810 4Fe-4S binding domain; Region: Fer4_5; pfam12801 330214005811 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 330214005812 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 330214005813 Protein of unknown function DUF72; Region: DUF72; pfam01904 330214005814 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 330214005815 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 330214005816 active site 330214005817 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 330214005818 generic binding surface II; other site 330214005819 generic binding surface I; other site 330214005820 DNA polymerase IV; Validated; Region: PRK01810 330214005821 Y-family of DNA polymerases; Region: PolY; cl12025 330214005822 DNA binding site [nucleotide binding] 330214005823 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 330214005824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 330214005825 non-specific DNA binding site [nucleotide binding]; other site 330214005826 salt bridge; other site 330214005827 sequence-specific DNA binding site [nucleotide binding]; other site 330214005828 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 330214005829 Catalytic site [active] 330214005830 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 330214005831 Protein of unknown function (DUF423); Region: DUF423; pfam04241 330214005832 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 330214005833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214005834 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 330214005835 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 330214005836 AsnC family; Region: AsnC_trans_reg; pfam01037 330214005837 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 330214005838 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 330214005839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005840 Walker A motif; other site 330214005841 ATP binding site [chemical binding]; other site 330214005842 Walker B motif; other site 330214005843 arginine finger; other site 330214005844 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 330214005845 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 330214005846 Clp amino terminal domain; Region: Clp_N; pfam02861 330214005847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005848 Walker A motif; other site 330214005849 ATP binding site [chemical binding]; other site 330214005850 Walker B motif; other site 330214005851 arginine finger; other site 330214005852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005853 Walker A motif; other site 330214005854 ATP binding site [chemical binding]; other site 330214005855 Walker B motif; other site 330214005856 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 330214005857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214005858 dimerization interface [polypeptide binding]; other site 330214005859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214005860 dimer interface [polypeptide binding]; other site 330214005861 phosphorylation site [posttranslational modification] 330214005862 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 330214005863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214005864 ATP binding site [chemical binding]; other site 330214005865 Mg2+ binding site [ion binding]; other site 330214005866 G-X-G motif; other site 330214005867 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 330214005868 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214005869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005870 active site 330214005871 phosphorylation site [posttranslational modification] 330214005872 intermolecular recognition site; other site 330214005873 dimerization interface [polypeptide binding]; other site 330214005874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005875 Walker A motif; other site 330214005876 ATP binding site [chemical binding]; other site 330214005877 Walker B motif; other site 330214005878 arginine finger; other site 330214005879 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 330214005880 PilZ domain; Region: PilZ; pfam07238 330214005881 PilZ domain; Region: PilZ; pfam07238 330214005882 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214005883 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 330214005884 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 330214005885 active site 330214005886 catalytic residues [active] 330214005887 DNA binding site [nucleotide binding] 330214005888 Int/Topo IB signature motif; other site 330214005889 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214005890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005891 active site 330214005892 phosphorylation site [posttranslational modification] 330214005893 intermolecular recognition site; other site 330214005894 dimerization interface [polypeptide binding]; other site 330214005895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005896 Walker A motif; other site 330214005897 ATP binding site [chemical binding]; other site 330214005898 Walker B motif; other site 330214005899 arginine finger; other site 330214005900 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214005901 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 330214005902 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 330214005903 PAS domain; Region: PAS; smart00091 330214005904 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214005905 putative active site [active] 330214005906 heme pocket [chemical binding]; other site 330214005907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214005908 dimer interface [polypeptide binding]; other site 330214005909 phosphorylation site [posttranslational modification] 330214005910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214005911 ATP binding site [chemical binding]; other site 330214005912 G-X-G motif; other site 330214005913 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214005914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005915 active site 330214005916 phosphorylation site [posttranslational modification] 330214005917 intermolecular recognition site; other site 330214005918 dimerization interface [polypeptide binding]; other site 330214005919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214005920 Walker A motif; other site 330214005921 ATP binding site [chemical binding]; other site 330214005922 Walker B motif; other site 330214005923 arginine finger; other site 330214005924 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214005925 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 330214005926 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 330214005927 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 330214005928 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 330214005929 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 330214005930 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 330214005931 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 330214005932 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 330214005933 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 330214005934 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 330214005935 FliG C-terminal domain; Region: FliG_C; pfam01706 330214005936 Response regulator receiver domain; Region: Response_reg; pfam00072 330214005937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214005938 active site 330214005939 phosphorylation site [posttranslational modification] 330214005940 intermolecular recognition site; other site 330214005941 dimerization interface [polypeptide binding]; other site 330214005942 Flagellar assembly protein FliH; Region: FliH; pfam02108 330214005943 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 330214005944 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 330214005945 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 330214005946 Walker A motif/ATP binding site; other site 330214005947 Walker B motif; other site 330214005948 Uncharacterized conserved protein [Function unknown]; Region: COG3334 330214005949 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 330214005950 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 330214005951 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 330214005952 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 330214005953 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 330214005954 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 330214005955 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 330214005956 flagellar motor switch protein FliN; Region: fliN; TIGR02480 330214005957 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 330214005958 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 330214005959 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 330214005960 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 330214005961 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 330214005962 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 330214005963 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 330214005964 FHIPEP family; Region: FHIPEP; pfam00771 330214005965 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 330214005966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214005967 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 330214005968 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214005969 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 330214005970 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 330214005971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214005972 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 330214005973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214005974 DNA binding residues [nucleotide binding] 330214005975 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 330214005976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 330214005977 metal binding site [ion binding]; metal-binding site 330214005978 active site 330214005979 I-site; other site 330214005980 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 330214005981 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 330214005982 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 330214005983 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 330214005984 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 330214005985 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 330214005986 SAF-like; Region: SAF_2; pfam13144 330214005987 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 330214005988 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 330214005989 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 330214005990 Flagellar L-ring protein; Region: FlgH; pfam02107 330214005991 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 330214005992 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 330214005993 Rod binding protein; Region: Rod-binding; cl01626 330214005994 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 330214005995 FlgN protein; Region: FlgN; pfam05130 330214005996 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 330214005997 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 330214005998 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 330214005999 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 330214006000 EthD domain; Region: EthD; cl17553 330214006001 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 330214006002 carbon storage regulator; Provisional; Region: PRK01712 330214006003 FliW protein; Region: FliW; cl00740 330214006004 PAS domain; Region: PAS; smart00091 330214006005 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214006006 PAS domain; Region: PAS; smart00091 330214006007 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214006008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214006009 dimer interface [polypeptide binding]; other site 330214006010 phosphorylation site [posttranslational modification] 330214006011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214006012 ATP binding site [chemical binding]; other site 330214006013 Mg2+ binding site [ion binding]; other site 330214006014 G-X-G motif; other site 330214006015 Response regulator receiver domain; Region: Response_reg; pfam00072 330214006016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006017 active site 330214006018 phosphorylation site [posttranslational modification] 330214006019 intermolecular recognition site; other site 330214006020 dimerization interface [polypeptide binding]; other site 330214006021 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214006022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006023 active site 330214006024 phosphorylation site [posttranslational modification] 330214006025 intermolecular recognition site; other site 330214006026 dimerization interface [polypeptide binding]; other site 330214006027 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214006028 putative binding surface; other site 330214006029 active site 330214006030 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 330214006031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214006032 Zn2+ binding site [ion binding]; other site 330214006033 Mg2+ binding site [ion binding]; other site 330214006034 Flagellar protein YcgR; Region: YcgR_2; pfam12945 330214006035 PilZ domain; Region: PilZ; pfam07238 330214006036 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 330214006037 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 330214006038 inhibitor-cofactor binding pocket; inhibition site 330214006039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214006040 catalytic residue [active] 330214006041 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214006042 extended (e) SDRs; Region: SDR_e; cd08946 330214006043 NAD(P) binding site [chemical binding]; other site 330214006044 active site 330214006045 substrate binding site [chemical binding]; other site 330214006046 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 330214006047 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 330214006048 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 330214006049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214006050 active site 330214006051 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 330214006052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214006053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214006054 homodimer interface [polypeptide binding]; other site 330214006055 catalytic residue [active] 330214006056 B12 binding domain; Region: B12-binding; pfam02310 330214006057 B12 binding site [chemical binding]; other site 330214006058 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 330214006059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214006060 FeS/SAM binding site; other site 330214006061 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 330214006062 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 330214006063 PYR/PP interface [polypeptide binding]; other site 330214006064 dimer interface [polypeptide binding]; other site 330214006065 TPP binding site [chemical binding]; other site 330214006066 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 330214006067 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 330214006068 TPP-binding site [chemical binding]; other site 330214006069 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 330214006070 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 330214006071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214006072 FeS/SAM binding site; other site 330214006073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214006074 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 330214006075 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214006076 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 330214006077 active site 330214006078 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214006079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214006080 S-adenosylmethionine binding site [chemical binding]; other site 330214006081 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214006082 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 330214006083 active site 330214006084 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 330214006085 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 330214006086 Probable Catalytic site; other site 330214006087 metal-binding site 330214006088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006089 TPR motif; other site 330214006090 binding surface 330214006091 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214006092 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214006093 putative active site [active] 330214006094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 330214006095 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 330214006096 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 330214006097 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214006098 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214006099 putative active site [active] 330214006100 flagellin; Provisional; Region: PRK12802 330214006101 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 330214006102 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 330214006103 FlaG protein; Region: FlaG; pfam03646 330214006104 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 330214006105 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 330214006106 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 330214006107 Flagellar protein FliS; Region: FliS; cl00654 330214006108 PilZ domain; Region: PilZ; pfam07238 330214006109 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 330214006110 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214006111 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214006112 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 330214006113 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 330214006114 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 330214006115 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 330214006116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006117 active site 330214006118 phosphorylation site [posttranslational modification] 330214006119 intermolecular recognition site; other site 330214006120 dimerization interface [polypeptide binding]; other site 330214006121 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 330214006122 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214006123 putative binding surface; other site 330214006124 active site 330214006125 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 330214006126 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 330214006127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214006128 ATP binding site [chemical binding]; other site 330214006129 Mg2+ binding site [ion binding]; other site 330214006130 G-X-G motif; other site 330214006131 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 330214006132 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 330214006133 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214006134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006135 active site 330214006136 phosphorylation site [posttranslational modification] 330214006137 intermolecular recognition site; other site 330214006138 dimerization interface [polypeptide binding]; other site 330214006139 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 330214006140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006141 active site 330214006142 phosphorylation site [posttranslational modification] 330214006143 intermolecular recognition site; other site 330214006144 CheB methylesterase; Region: CheB_methylest; pfam01339 330214006145 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214006146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214006147 dimerization interface [polypeptide binding]; other site 330214006148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 330214006149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 330214006150 dimer interface [polypeptide binding]; other site 330214006151 putative CheW interface [polypeptide binding]; other site 330214006152 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 330214006153 putative CheA interaction surface; other site 330214006154 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 330214006155 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 330214006156 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 330214006157 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 330214006158 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214006159 ligand binding site [chemical binding]; other site 330214006160 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 330214006161 anti sigma factor interaction site; other site 330214006162 regulatory phosphorylation site [posttranslational modification]; other site 330214006163 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 330214006164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 330214006165 dimer interface [polypeptide binding]; other site 330214006166 putative CheW interface [polypeptide binding]; other site 330214006167 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214006168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006169 active site 330214006170 phosphorylation site [posttranslational modification] 330214006171 intermolecular recognition site; other site 330214006172 dimerization interface [polypeptide binding]; other site 330214006173 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 330214006174 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214006175 putative binding surface; other site 330214006176 active site 330214006177 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 330214006178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214006179 ATP binding site [chemical binding]; other site 330214006180 Mg2+ binding site [ion binding]; other site 330214006181 G-X-G motif; other site 330214006182 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 330214006183 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 330214006184 putative CheA interaction surface; other site 330214006185 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 330214006186 heme-binding site [chemical binding]; other site 330214006187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214006188 PAS domain; Region: PAS_9; pfam13426 330214006189 putative active site [active] 330214006190 heme pocket [chemical binding]; other site 330214006191 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 330214006192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 330214006193 dimer interface [polypeptide binding]; other site 330214006194 putative CheW interface [polypeptide binding]; other site 330214006195 Protein of unknown function (DUF420); Region: DUF420; cl00989 330214006196 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 330214006197 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 330214006198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214006199 CheD chemotactic sensory transduction; Region: CheD; cl00810 330214006200 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 330214006201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006202 active site 330214006203 phosphorylation site [posttranslational modification] 330214006204 intermolecular recognition site; other site 330214006205 dimerization interface [polypeptide binding]; other site 330214006206 CheB methylesterase; Region: CheB_methylest; pfam01339 330214006207 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 330214006208 anti sigma factor interaction site; other site 330214006209 regulatory phosphorylation site [posttranslational modification]; other site 330214006210 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 330214006211 anti sigma factor interaction site; other site 330214006212 regulatory phosphorylation site [posttranslational modification]; other site 330214006213 Response regulator receiver domain; Region: Response_reg; pfam00072 330214006214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006215 active site 330214006216 phosphorylation site [posttranslational modification] 330214006217 intermolecular recognition site; other site 330214006218 dimerization interface [polypeptide binding]; other site 330214006219 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 330214006220 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 330214006221 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 330214006222 transcriptional regulator PhoB; Provisional; Region: PRK10161 330214006223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006224 active site 330214006225 phosphorylation site [posttranslational modification] 330214006226 intermolecular recognition site; other site 330214006227 dimerization interface [polypeptide binding]; other site 330214006228 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 330214006229 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 330214006230 YcfA-like protein; Region: YcfA; pfam07927 330214006231 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 330214006232 active site 330214006233 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 330214006234 homodimer interface [polypeptide binding]; other site 330214006235 Protein of unknown function (DUF433); Region: DUF433; cl01030 330214006236 Protein of unknown function (DUF497); Region: DUF497; pfam04365 330214006237 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 330214006238 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 330214006239 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 330214006240 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 330214006241 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 330214006242 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 330214006243 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 330214006244 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214006245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 330214006246 active site 330214006247 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 330214006248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214006249 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214006250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214006251 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214006252 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214006253 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214006254 putative active site [active] 330214006255 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 330214006256 active site 330214006257 CoA binding site [chemical binding]; other site 330214006258 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 330214006259 putative glycosyl transferase; Provisional; Region: PRK10307 330214006260 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 330214006261 VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370 330214006262 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 330214006263 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 330214006264 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 330214006265 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 330214006266 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 330214006267 Mg++ binding site [ion binding]; other site 330214006268 putative catalytic motif [active] 330214006269 substrate binding site [chemical binding]; other site 330214006270 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 330214006271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006272 binding surface 330214006273 TPR motif; other site 330214006274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006275 binding surface 330214006276 TPR motif; other site 330214006277 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 330214006278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006279 binding surface 330214006280 TPR motif; other site 330214006281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214006282 binding surface 330214006283 TPR motif; other site 330214006284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006285 binding surface 330214006286 TPR motif; other site 330214006287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006288 TPR motif; other site 330214006289 binding surface 330214006290 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214006291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006292 TPR motif; other site 330214006293 binding surface 330214006294 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214006295 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 330214006296 SLBB domain; Region: SLBB; pfam10531 330214006297 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 330214006298 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 330214006299 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 330214006300 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 330214006301 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 330214006302 putative NAD(P) binding site [chemical binding]; other site 330214006303 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 330214006304 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214006305 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 330214006306 AAA ATPase domain; Region: AAA_16; pfam13191 330214006307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006308 binding surface 330214006309 TPR motif; other site 330214006310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214006311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 330214006312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006313 active site 330214006314 phosphorylation site [posttranslational modification] 330214006315 intermolecular recognition site; other site 330214006316 dimerization interface [polypeptide binding]; other site 330214006317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 330214006318 DNA binding site [nucleotide binding] 330214006319 CHAD domain; Region: CHAD; cl10506 330214006320 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 330214006321 catalytic core [active] 330214006322 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 330214006323 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 330214006324 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214006325 Zn2+ binding site [ion binding]; other site 330214006326 Mg2+ binding site [ion binding]; other site 330214006327 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 330214006328 PhoU domain; Region: PhoU; pfam01895 330214006329 PhoU domain; Region: PhoU; pfam01895 330214006330 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 330214006331 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 330214006332 Walker A/P-loop; other site 330214006333 ATP binding site [chemical binding]; other site 330214006334 Q-loop/lid; other site 330214006335 ABC transporter signature motif; other site 330214006336 Walker B; other site 330214006337 D-loop; other site 330214006338 H-loop/switch region; other site 330214006339 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 330214006340 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 330214006341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214006342 dimer interface [polypeptide binding]; other site 330214006343 conserved gate region; other site 330214006344 putative PBP binding loops; other site 330214006345 ABC-ATPase subunit interface; other site 330214006346 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 330214006347 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 330214006348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214006349 putative PBP binding loops; other site 330214006350 ABC-ATPase subunit interface; other site 330214006351 PBP superfamily domain; Region: PBP_like_2; cl17296 330214006352 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 330214006353 PBP superfamily domain; Region: PBP_like_2; cl17296 330214006354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 330214006355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006356 active site 330214006357 phosphorylation site [posttranslational modification] 330214006358 intermolecular recognition site; other site 330214006359 dimerization interface [polypeptide binding]; other site 330214006360 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 330214006361 DNA binding site [nucleotide binding] 330214006362 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 330214006363 PBP superfamily domain; Region: PBP_like_2; cl17296 330214006364 PBP superfamily domain; Region: PBP_like_2; cl17296 330214006365 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 330214006366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 330214006367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 330214006368 DNA binding site [nucleotide binding] 330214006369 FOG: CBS domain [General function prediction only]; Region: COG0517 330214006370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214006371 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214006372 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214006373 ligand binding site [chemical binding]; other site 330214006374 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 330214006375 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 330214006376 catalytic residues [active] 330214006377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 330214006378 active site 330214006379 catalytic tetrad [active] 330214006380 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 330214006381 active site 330214006382 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 330214006383 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 330214006384 Malic enzyme, N-terminal domain; Region: malic; pfam00390 330214006385 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 330214006386 NAD(P) binding pocket [chemical binding]; other site 330214006387 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 330214006388 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 330214006389 HSP70 interaction site [polypeptide binding]; other site 330214006390 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 330214006391 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 330214006392 catalytic site [active] 330214006393 putative active site [active] 330214006394 putative substrate binding site [chemical binding]; other site 330214006395 HRDC domain; Region: HRDC; pfam00570 330214006396 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214006397 ArsC family; Region: ArsC; pfam03960 330214006398 citrate synthase; Provisional; Region: PRK14036 330214006399 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 330214006400 oxalacetate binding site [chemical binding]; other site 330214006401 citrylCoA binding site [chemical binding]; other site 330214006402 coenzyme A binding site [chemical binding]; other site 330214006403 catalytic triad [active] 330214006404 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 330214006405 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 330214006406 putative dimer interface [polypeptide binding]; other site 330214006407 fumarate hydratase; Reviewed; Region: fumC; PRK00485 330214006408 Class II fumarases; Region: Fumarase_classII; cd01362 330214006409 active site 330214006410 tetramer interface [polypeptide binding]; other site 330214006411 ferredoxin-NADP+ reductase; Region: PLN02852 330214006412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 330214006413 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 330214006414 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 330214006415 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 330214006416 Clp amino terminal domain; Region: Clp_N; pfam02861 330214006417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214006418 Walker A motif; other site 330214006419 ATP binding site [chemical binding]; other site 330214006420 Walker B motif; other site 330214006421 arginine finger; other site 330214006422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214006423 Walker A motif; other site 330214006424 ATP binding site [chemical binding]; other site 330214006425 Walker B motif; other site 330214006426 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 330214006427 UGMP family protein; Validated; Region: PRK09604 330214006428 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 330214006429 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 330214006430 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 330214006431 HflX GTPase family; Region: HflX; cd01878 330214006432 G1 box; other site 330214006433 GTP/Mg2+ binding site [chemical binding]; other site 330214006434 Switch I region; other site 330214006435 G2 box; other site 330214006436 G3 box; other site 330214006437 Switch II region; other site 330214006438 G4 box; other site 330214006439 G5 box; other site 330214006440 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 330214006441 endonuclease III; Region: ENDO3c; smart00478 330214006442 minor groove reading motif; other site 330214006443 helix-hairpin-helix signature motif; other site 330214006444 substrate binding pocket [chemical binding]; other site 330214006445 active site 330214006446 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 330214006447 hypothetical protein; Provisional; Region: PRK11820 330214006448 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 330214006449 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 330214006450 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 330214006451 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 330214006452 catalytic site [active] 330214006453 G-X2-G-X-G-K; other site 330214006454 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 330214006455 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 330214006456 Flavoprotein; Region: Flavoprotein; pfam02441 330214006457 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 330214006458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006459 binding surface 330214006460 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214006461 TPR motif; other site 330214006462 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214006463 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 330214006464 Dehydroquinase class II; Region: DHquinase_II; pfam01220 330214006465 active site 330214006466 trimer interface [polypeptide binding]; other site 330214006467 dimer interface [polypeptide binding]; other site 330214006468 elongation factor P; Validated; Region: PRK00529 330214006469 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 330214006470 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 330214006471 RNA binding site [nucleotide binding]; other site 330214006472 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 330214006473 RNA binding site [nucleotide binding]; other site 330214006474 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 330214006475 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 330214006476 carboxyltransferase (CT) interaction site; other site 330214006477 biotinylation site [posttranslational modification]; other site 330214006478 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 330214006479 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 330214006480 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 330214006481 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 330214006482 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 330214006483 active site 330214006484 thiamine phosphate binding site [chemical binding]; other site 330214006485 pyrophosphate binding site [ion binding]; other site 330214006486 AAA domain; Region: AAA_26; pfam13500 330214006487 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 330214006488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 330214006489 classical (c) SDRs; Region: SDR_c; cd05233 330214006490 NAD(P) binding site [chemical binding]; other site 330214006491 active site 330214006492 Proline dehydrogenase; Region: Pro_dh; cl03282 330214006493 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 330214006494 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 330214006495 Glutamate binding site [chemical binding]; other site 330214006496 homodimer interface [polypeptide binding]; other site 330214006497 NAD binding site [chemical binding]; other site 330214006498 catalytic residues [active] 330214006499 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 330214006500 Fatty acid desaturase; Region: FA_desaturase; pfam00487 330214006501 Di-iron ligands [ion binding]; other site 330214006502 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 330214006503 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 330214006504 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 330214006505 [2Fe-2S] cluster binding site [ion binding]; other site 330214006506 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 330214006507 MutL protein; Region: MutL; pfam13941 330214006508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 330214006509 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 330214006510 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 330214006511 putative ligand binding pocket/active site [active] 330214006512 putative metal binding site [ion binding]; other site 330214006513 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 330214006514 active site 330214006515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 330214006516 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 330214006517 PemK-like protein; Region: PemK; pfam02452 330214006518 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 330214006519 HsdM N-terminal domain; Region: HsdM_N; pfam12161 330214006520 Methyltransferase domain; Region: Methyltransf_26; pfam13659 330214006521 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 330214006522 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 330214006523 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 330214006524 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 330214006525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 330214006526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214006527 salt bridge; other site 330214006528 non-specific DNA binding site [nucleotide binding]; other site 330214006529 sequence-specific DNA binding site [nucleotide binding]; other site 330214006530 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 330214006531 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 330214006532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214006533 ATP binding site [chemical binding]; other site 330214006534 putative Mg++ binding site [ion binding]; other site 330214006535 hypothetical protein; Reviewed; Region: PRK00024 330214006536 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 330214006537 MPN+ (JAMM) motif; other site 330214006538 Zinc-binding site [ion binding]; other site 330214006539 PemK-like protein; Region: PemK; pfam02452 330214006540 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 330214006541 PemK-like protein; Region: PemK; pfam02452 330214006542 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 330214006543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214006544 D-galactonate transporter; Region: 2A0114; TIGR00893 330214006545 putative substrate translocation pore; other site 330214006546 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 330214006547 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 330214006548 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 330214006549 active site 330214006550 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 330214006551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 330214006552 catalytic loop [active] 330214006553 iron binding site [ion binding]; other site 330214006554 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 330214006555 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 330214006556 hypothetical protein; Reviewed; Region: PRK09588 330214006557 PilZ domain; Region: PilZ; pfam07238 330214006558 Response regulator receiver domain; Region: Response_reg; pfam00072 330214006559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006560 active site 330214006561 phosphorylation site [posttranslational modification] 330214006562 intermolecular recognition site; other site 330214006563 dimerization interface [polypeptide binding]; other site 330214006564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214006565 PAS fold; Region: PAS_3; pfam08447 330214006566 putative active site [active] 330214006567 heme pocket [chemical binding]; other site 330214006568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 330214006569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 330214006570 metal binding site [ion binding]; metal-binding site 330214006571 active site 330214006572 I-site; other site 330214006573 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 330214006574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006575 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214006576 binding surface 330214006577 TPR motif; other site 330214006578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006579 binding surface 330214006580 TPR motif; other site 330214006581 TPR repeat; Region: TPR_11; pfam13414 330214006582 TPR repeat; Region: TPR_11; pfam13414 330214006583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006584 binding surface 330214006585 TPR motif; other site 330214006586 TPR repeat; Region: TPR_11; pfam13414 330214006587 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 330214006588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214006589 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 330214006590 HDOD domain; Region: HDOD; pfam08668 330214006591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 330214006592 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 330214006593 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 330214006594 Cysteine-rich domain; Region: CCG; pfam02754 330214006595 Cysteine-rich domain; Region: CCG; pfam02754 330214006596 Cupin domain; Region: Cupin_2; pfam07883 330214006597 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214006598 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 330214006599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 330214006600 substrate binding pocket [chemical binding]; other site 330214006601 membrane-bound complex binding site; other site 330214006602 hinge residues; other site 330214006603 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 330214006604 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 330214006605 Multicopper oxidase; Region: Cu-oxidase; pfam00394 330214006606 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 330214006607 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 330214006608 ligand binding site [chemical binding]; other site 330214006609 flexible hinge region; other site 330214006610 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 330214006611 putative switch regulator; other site 330214006612 non-specific DNA interactions [nucleotide binding]; other site 330214006613 DNA binding site [nucleotide binding] 330214006614 sequence specific DNA binding site [nucleotide binding]; other site 330214006615 putative cAMP binding site [chemical binding]; other site 330214006616 transketolase; Reviewed; Region: PRK05899 330214006617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 330214006618 TPP-binding site [chemical binding]; other site 330214006619 dimer interface [polypeptide binding]; other site 330214006620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 330214006621 PYR/PP interface [polypeptide binding]; other site 330214006622 dimer interface [polypeptide binding]; other site 330214006623 TPP binding site [chemical binding]; other site 330214006624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214006625 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 330214006626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214006627 active site 330214006628 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 330214006629 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 330214006630 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 330214006631 dihydroorotase; Validated; Region: pyrC; PRK09357 330214006632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 330214006633 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 330214006634 active site 330214006635 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 330214006636 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 330214006637 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 330214006638 catalytic site [active] 330214006639 subunit interface [polypeptide binding]; other site 330214006640 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 330214006641 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 330214006642 tandem repeat interface [polypeptide binding]; other site 330214006643 oligomer interface [polypeptide binding]; other site 330214006644 active site residues [active] 330214006645 Peptidase family M48; Region: Peptidase_M48; pfam01435 330214006646 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 330214006647 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 330214006648 ATP-grasp domain; Region: ATP-grasp_4; cl17255 330214006649 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 330214006650 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 330214006651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 330214006652 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 330214006653 IMP binding site; other site 330214006654 dimer interface [polypeptide binding]; other site 330214006655 interdomain contacts; other site 330214006656 partial ornithine binding site; other site 330214006657 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 330214006658 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 330214006659 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 330214006660 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 330214006661 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214006662 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 330214006663 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214006664 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 330214006665 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 330214006666 inhibitor-cofactor binding pocket; inhibition site 330214006667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214006668 catalytic residue [active] 330214006669 GTP-binding protein LepA; Provisional; Region: PRK05433 330214006670 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 330214006671 G1 box; other site 330214006672 putative GEF interaction site [polypeptide binding]; other site 330214006673 GTP/Mg2+ binding site [chemical binding]; other site 330214006674 Switch I region; other site 330214006675 G2 box; other site 330214006676 G3 box; other site 330214006677 Switch II region; other site 330214006678 G4 box; other site 330214006679 G5 box; other site 330214006680 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 330214006681 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 330214006682 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 330214006683 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 330214006684 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 330214006685 Catalytic site [active] 330214006686 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 330214006687 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 330214006688 putative ribose interaction site [chemical binding]; other site 330214006689 putative ADP binding site [chemical binding]; other site 330214006690 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 330214006691 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 330214006692 Ligand binding site; other site 330214006693 oligomer interface; other site 330214006694 CTP synthetase; Validated; Region: pyrG; PRK05380 330214006695 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 330214006696 Catalytic site [active] 330214006697 active site 330214006698 UTP binding site [chemical binding]; other site 330214006699 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 330214006700 active site 330214006701 putative oxyanion hole; other site 330214006702 catalytic triad [active] 330214006703 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 330214006704 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 330214006705 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 330214006706 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 330214006707 putative active site [active] 330214006708 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 330214006709 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 330214006710 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 330214006711 TrkA-C domain; Region: TrkA_C; pfam02080 330214006712 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 330214006713 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214006714 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214006715 protein binding site [polypeptide binding]; other site 330214006716 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214006717 protein binding site [polypeptide binding]; other site 330214006718 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 330214006719 elongation factor G; Reviewed; Region: PRK12740 330214006720 G1 box; other site 330214006721 putative GEF interaction site [polypeptide binding]; other site 330214006722 GTP/Mg2+ binding site [chemical binding]; other site 330214006723 Switch I region; other site 330214006724 G2 box; other site 330214006725 G3 box; other site 330214006726 Switch II region; other site 330214006727 G4 box; other site 330214006728 G5 box; other site 330214006729 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 330214006730 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 330214006731 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 330214006732 hypothetical protein; Reviewed; Region: PRK00024 330214006733 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 330214006734 MPN+ (JAMM) motif; other site 330214006735 Zinc-binding site [ion binding]; other site 330214006736 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 330214006737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214006738 S-adenosylmethionine binding site [chemical binding]; other site 330214006739 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 330214006740 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 330214006741 active site 330214006742 (T/H)XGH motif; other site 330214006743 aspartate aminotransferase; Provisional; Region: PRK05764 330214006744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214006745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214006746 homodimer interface [polypeptide binding]; other site 330214006747 catalytic residue [active] 330214006748 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 330214006749 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 330214006750 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 330214006751 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 330214006752 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 330214006753 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 330214006754 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 330214006755 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 330214006756 purine monophosphate binding site [chemical binding]; other site 330214006757 dimer interface [polypeptide binding]; other site 330214006758 putative catalytic residues [active] 330214006759 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 330214006760 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 330214006761 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214006762 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214006763 ligand binding site [chemical binding]; other site 330214006764 Uncharacterized conserved protein [Function unknown]; Region: COG3743 330214006765 NnrS protein; Region: NnrS; pfam05940 330214006766 ST7 protein; Region: ST7; pfam04184 330214006767 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 330214006768 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 330214006769 active site 330214006770 PHP Thumb interface [polypeptide binding]; other site 330214006771 metal binding site [ion binding]; metal-binding site 330214006772 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 330214006773 generic binding surface II; other site 330214006774 generic binding surface I; other site 330214006775 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 330214006776 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 330214006777 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 330214006778 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 330214006779 dinuclear metal binding motif [ion binding]; other site 330214006780 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 330214006781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214006782 ATP binding site [chemical binding]; other site 330214006783 putative Mg++ binding site [ion binding]; other site 330214006784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214006785 nucleotide binding region [chemical binding]; other site 330214006786 Helicase associated domain (HA2); Region: HA2; pfam04408 330214006787 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 330214006788 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 330214006789 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 330214006790 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 330214006791 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 330214006792 active site 330214006793 catalytic residues [active] 330214006794 metal binding site [ion binding]; metal-binding site 330214006795 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 330214006796 Sel1-like repeats; Region: SEL1; smart00671 330214006797 Sel1 repeat; Region: Sel1; cl02723 330214006798 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 330214006799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 330214006800 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 330214006801 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214006802 RNA binding surface [nucleotide binding]; other site 330214006803 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 330214006804 active site 330214006805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 330214006806 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 330214006807 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214006808 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 330214006809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 330214006810 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 330214006811 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 330214006812 homodimer interface [polypeptide binding]; other site 330214006813 chemical substrate binding site [chemical binding]; other site 330214006814 oligomer interface [polypeptide binding]; other site 330214006815 metal binding site [ion binding]; metal-binding site 330214006816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 330214006817 Helix-turn-helix domain; Region: HTH_38; pfam13936 330214006818 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 330214006819 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 330214006820 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 330214006821 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 330214006822 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 330214006823 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 330214006824 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 330214006825 HflX GTPase family; Region: HflX; cd01878 330214006826 G1 box; other site 330214006827 GTP/Mg2+ binding site [chemical binding]; other site 330214006828 Switch I region; other site 330214006829 G2 box; other site 330214006830 G3 box; other site 330214006831 Switch II region; other site 330214006832 G4 box; other site 330214006833 G5 box; other site 330214006834 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 330214006835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 330214006836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214006837 sequence-specific DNA binding site [nucleotide binding]; other site 330214006838 salt bridge; other site 330214006839 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 330214006840 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 330214006841 active site 330214006842 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 330214006843 active site 330214006844 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 330214006845 DEAD-like helicases superfamily; Region: DEXDc; smart00487 330214006846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214006847 ATP binding site [chemical binding]; other site 330214006848 putative Mg++ binding site [ion binding]; other site 330214006849 Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; Region: NF-X1-zinc-finger; cd06008 330214006850 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 330214006851 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 330214006852 Virulence protein [General function prediction only]; Region: COG3943 330214006853 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 330214006854 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 330214006855 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 330214006856 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 330214006857 HsdM N-terminal domain; Region: HsdM_N; pfam12161 330214006858 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 330214006859 Methyltransferase domain; Region: Methyltransf_26; pfam13659 330214006860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214006861 non-specific DNA binding site [nucleotide binding]; other site 330214006862 salt bridge; other site 330214006863 sequence-specific DNA binding site [nucleotide binding]; other site 330214006864 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 330214006865 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214006866 GAF domain; Region: GAF; pfam01590 330214006867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214006868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 330214006869 dimer interface [polypeptide binding]; other site 330214006870 phosphorylation site [posttranslational modification] 330214006871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214006872 ATP binding site [chemical binding]; other site 330214006873 Mg2+ binding site [ion binding]; other site 330214006874 G-X-G motif; other site 330214006875 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214006876 Methyltransferase domain; Region: Methyltransf_18; pfam12847 330214006877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214006878 non-specific DNA binding site [nucleotide binding]; other site 330214006879 salt bridge; other site 330214006880 sequence-specific DNA binding site [nucleotide binding]; other site 330214006881 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 330214006882 WYL domain; Region: WYL; pfam13280 330214006883 Predicted transcriptional regulator [Transcription]; Region: COG2378 330214006884 HTH domain; Region: HTH_11; pfam08279 330214006885 WYL domain; Region: WYL; pfam13280 330214006886 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 330214006887 FAD binding domain; Region: FAD_binding_4; pfam01565 330214006888 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 330214006889 Cysteine-rich domain; Region: CCG; pfam02754 330214006890 Cysteine-rich domain; Region: CCG; pfam02754 330214006891 glyoxylate reductase; Reviewed; Region: PRK13243 330214006892 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 330214006893 dimerization interface [polypeptide binding]; other site 330214006894 ligand binding site [chemical binding]; other site 330214006895 NADP binding site [chemical binding]; other site 330214006896 catalytic site [active] 330214006897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006898 binding surface 330214006899 TPR repeat; Region: TPR_11; pfam13414 330214006900 TPR motif; other site 330214006901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006902 binding surface 330214006903 TPR motif; other site 330214006904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214006905 binding surface 330214006906 TPR motif; other site 330214006907 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 330214006908 DNA-binding site [nucleotide binding]; DNA binding site 330214006909 RNA-binding motif; other site 330214006910 Predicted permeases [General function prediction only]; Region: COG0795 330214006911 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 330214006912 Predicted permeases [General function prediction only]; Region: COG0795 330214006913 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 330214006914 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 330214006915 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 330214006916 dimer interface [polypeptide binding]; other site 330214006917 active site 330214006918 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 330214006919 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 330214006920 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 330214006921 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 330214006922 trimer interface [polypeptide binding]; other site 330214006923 active site 330214006924 UDP-GlcNAc binding site [chemical binding]; other site 330214006925 lipid binding site [chemical binding]; lipid-binding site 330214006926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214006927 Zn2+ binding site [ion binding]; other site 330214006928 Mg2+ binding site [ion binding]; other site 330214006929 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 330214006930 Response regulator receiver domain; Region: Response_reg; pfam00072 330214006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006932 active site 330214006933 phosphorylation site [posttranslational modification] 330214006934 intermolecular recognition site; other site 330214006935 dimerization interface [polypeptide binding]; other site 330214006936 CheW-like domain; Region: CheW; pfam01584 330214006937 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 330214006938 Hpt domain; Region: Hpt; pfam01627 330214006939 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214006940 putative binding surface; other site 330214006941 active site 330214006942 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 330214006943 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 330214006944 putative binding surface; other site 330214006945 active site 330214006946 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 330214006947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214006948 ATP binding site [chemical binding]; other site 330214006949 Mg2+ binding site [ion binding]; other site 330214006950 G-X-G motif; other site 330214006951 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 330214006952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006953 Response regulator receiver domain; Region: Response_reg; pfam00072 330214006954 active site 330214006955 phosphorylation site [posttranslational modification] 330214006956 intermolecular recognition site; other site 330214006957 dimerization interface [polypeptide binding]; other site 330214006958 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 330214006959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214006960 dimerization interface [polypeptide binding]; other site 330214006961 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 330214006962 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 330214006963 dimer interface [polypeptide binding]; other site 330214006964 putative CheW interface [polypeptide binding]; other site 330214006965 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 330214006966 Response regulator receiver domain; Region: Response_reg; pfam00072 330214006967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214006968 active site 330214006969 phosphorylation site [posttranslational modification] 330214006970 intermolecular recognition site; other site 330214006971 dimerization interface [polypeptide binding]; other site 330214006972 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214006973 cobyric acid synthase; Provisional; Region: PRK00784 330214006974 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 330214006975 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 330214006976 catalytic triad [active] 330214006977 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 330214006978 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 330214006979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214006980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214006981 homodimer interface [polypeptide binding]; other site 330214006982 catalytic residue [active] 330214006983 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 330214006984 cobalamin synthase; Reviewed; Region: cobS; PRK00235 330214006985 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 330214006986 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 330214006987 putative dimer interface [polypeptide binding]; other site 330214006988 active site pocket [active] 330214006989 putative cataytic base [active] 330214006990 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 330214006991 homotrimer interface [polypeptide binding]; other site 330214006992 Walker A motif; other site 330214006993 GTP binding site [chemical binding]; other site 330214006994 Walker B motif; other site 330214006995 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 330214006996 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 330214006997 putative FMN binding site [chemical binding]; other site 330214006998 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 330214006999 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 330214007000 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 330214007001 homodimer interface [polypeptide binding]; other site 330214007002 Walker A motif; other site 330214007003 ATP binding site [chemical binding]; other site 330214007004 hydroxycobalamin binding site [chemical binding]; other site 330214007005 Walker B motif; other site 330214007006 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 330214007007 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 330214007008 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 330214007009 catalytic triad [active] 330214007010 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 330214007011 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214007012 N-terminal plug; other site 330214007013 ligand-binding site [chemical binding]; other site 330214007014 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 330214007015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 330214007016 Walker A/P-loop; other site 330214007017 ATP binding site [chemical binding]; other site 330214007018 Q-loop/lid; other site 330214007019 ABC transporter signature motif; other site 330214007020 Walker B; other site 330214007021 D-loop; other site 330214007022 H-loop/switch region; other site 330214007023 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 330214007024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 330214007025 ABC-ATPase subunit interface; other site 330214007026 dimer interface [polypeptide binding]; other site 330214007027 putative PBP binding regions; other site 330214007028 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 330214007029 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 330214007030 cobalamin binding residues [chemical binding]; other site 330214007031 putative BtuC binding residues; other site 330214007032 dimer interface [polypeptide binding]; other site 330214007033 Uncharacterized conserved protein [Function unknown]; Region: COG4095 330214007034 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 330214007035 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 330214007036 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214007037 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 330214007038 SLBB domain; Region: SLBB; pfam10531 330214007039 SLBB domain; Region: SLBB; pfam10531 330214007040 SLBB domain; Region: SLBB; pfam10531 330214007041 SLBB domain; Region: SLBB; pfam10531 330214007042 SLBB domain; Region: SLBB; pfam10531 330214007043 SLBB domain; Region: SLBB; pfam10531 330214007044 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214007045 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 330214007046 SLBB domain; Region: SLBB; pfam10531 330214007047 SLBB domain; Region: SLBB; pfam10531 330214007048 SLBB domain; Region: SLBB; pfam10531 330214007049 SLBB domain; Region: SLBB; pfam10531 330214007050 SLBB domain; Region: SLBB; pfam10531 330214007051 SLBB domain; Region: SLBB; pfam10531 330214007052 SLBB domain; Region: SLBB; pfam10531 330214007053 SLBB domain; Region: SLBB; pfam10531 330214007054 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214007055 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 330214007056 SLBB domain; Region: SLBB; pfam10531 330214007057 SLBB domain; Region: SLBB; pfam10531 330214007058 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 330214007059 CoA binding domain; Region: CoA_binding; cl17356 330214007060 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 330214007061 NAD(P) binding site [chemical binding]; other site 330214007062 homodimer interface [polypeptide binding]; other site 330214007063 substrate binding site [chemical binding]; other site 330214007064 active site 330214007065 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 330214007066 putative active site [active] 330214007067 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 330214007068 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 330214007069 inhibitor-cofactor binding pocket; inhibition site 330214007070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214007071 catalytic residue [active] 330214007072 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 330214007073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214007074 Coenzyme A binding pocket [chemical binding]; other site 330214007075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 330214007076 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 330214007077 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 330214007078 putative trimer interface [polypeptide binding]; other site 330214007079 putative CoA binding site [chemical binding]; other site 330214007080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007081 S-adenosylmethionine binding site [chemical binding]; other site 330214007082 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 330214007083 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 330214007084 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 330214007085 acyl-activating enzyme (AAE) consensus motif; other site 330214007086 AMP binding site [chemical binding]; other site 330214007087 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 330214007088 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 330214007089 Bacterial sugar transferase; Region: Bac_transf; pfam02397 330214007090 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214007091 active site 330214007092 oxyanion hole [active] 330214007093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007094 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 330214007095 putative ADP-binding pocket [chemical binding]; other site 330214007096 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 330214007097 putative active site [active] 330214007098 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 330214007099 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 330214007100 active site 330214007101 dimer interface [polypeptide binding]; other site 330214007102 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 330214007103 Ligand Binding Site [chemical binding]; other site 330214007104 Molecular Tunnel; other site 330214007105 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 330214007106 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 330214007107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007108 putative ADP-binding pocket [chemical binding]; other site 330214007109 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 330214007110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007111 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 330214007112 putative ADP-binding pocket [chemical binding]; other site 330214007113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007114 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 330214007115 putative ADP-binding pocket [chemical binding]; other site 330214007116 Integrase core domain; Region: rve_3; pfam13683 330214007117 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 330214007118 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 330214007119 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 330214007120 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 330214007121 Chain length determinant protein; Region: Wzz; pfam02706 330214007122 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 330214007123 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 330214007124 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 330214007125 Transposase; Region: HTH_Tnp_1; pfam01527 330214007126 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 330214007127 Transcription antiterminator [Transcription]; Region: NusG; COG0250 330214007128 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214007129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214007130 active site 330214007131 phosphorylation site [posttranslational modification] 330214007132 intermolecular recognition site; other site 330214007133 dimerization interface [polypeptide binding]; other site 330214007134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214007135 DNA binding residues [nucleotide binding] 330214007136 dimerization interface [polypeptide binding]; other site 330214007137 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 330214007138 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214007139 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214007140 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214007141 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214007142 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 330214007143 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 330214007144 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 330214007145 substrate binding site [chemical binding]; other site 330214007146 Peptidase family M50; Region: Peptidase_M50; pfam02163 330214007147 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 330214007148 active site 330214007149 putative substrate binding region [chemical binding]; other site 330214007150 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214007151 GAF domain; Region: GAF; pfam01590 330214007152 GAF domain; Region: GAF_2; pfam13185 330214007153 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214007154 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214007155 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 330214007156 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 330214007157 active site 330214007158 HIGH motif; other site 330214007159 dimer interface [polypeptide binding]; other site 330214007160 KMSKS motif; other site 330214007161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214007162 RNA binding surface [nucleotide binding]; other site 330214007163 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 330214007164 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 330214007165 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 330214007166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 330214007167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214007168 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 330214007169 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 330214007170 lipoyl attachment site [posttranslational modification]; other site 330214007171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214007172 binding surface 330214007173 TPR motif; other site 330214007174 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 330214007175 active site 330214007176 multimer interface [polypeptide binding]; other site 330214007177 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 330214007178 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 330214007179 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 330214007180 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 330214007181 inhibitor-cofactor binding pocket; inhibition site 330214007182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214007183 catalytic residue [active] 330214007184 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007185 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 330214007186 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 330214007187 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 330214007188 Competence protein; Region: Competence; pfam03772 330214007189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 330214007190 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 330214007191 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 330214007192 active site 330214007193 substrate binding site [chemical binding]; other site 330214007194 metal binding site [ion binding]; metal-binding site 330214007195 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 330214007196 dihydropteroate synthase; Region: DHPS; TIGR01496 330214007197 substrate binding pocket [chemical binding]; other site 330214007198 dimer interface [polypeptide binding]; other site 330214007199 inhibitor binding site; inhibition site 330214007200 FtsH Extracellular; Region: FtsH_ext; pfam06480 330214007201 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 330214007202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214007203 Walker A motif; other site 330214007204 ATP binding site [chemical binding]; other site 330214007205 Walker B motif; other site 330214007206 arginine finger; other site 330214007207 Peptidase family M41; Region: Peptidase_M41; pfam01434 330214007208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214007209 active site 330214007210 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 330214007211 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 330214007212 Ligand Binding Site [chemical binding]; other site 330214007213 TilS substrate C-terminal domain; Region: TilS_C; smart00977 330214007214 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 330214007215 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 330214007216 active site 330214007217 Riboflavin kinase; Region: Flavokinase; pfam01687 330214007218 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 330214007219 dimer interface [polypeptide binding]; other site 330214007220 active site 330214007221 Schiff base residues; other site 330214007222 FOG: CBS domain [General function prediction only]; Region: COG0517 330214007223 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214007224 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 330214007225 active site 330214007226 SAM binding site [chemical binding]; other site 330214007227 homodimer interface [polypeptide binding]; other site 330214007228 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 330214007229 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 330214007230 active site 330214007231 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 330214007232 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 330214007233 domain interfaces; other site 330214007234 active site 330214007235 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 330214007236 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 330214007237 tRNA; other site 330214007238 putative tRNA binding site [nucleotide binding]; other site 330214007239 putative NADP binding site [chemical binding]; other site 330214007240 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 330214007241 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 330214007242 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 330214007243 homodimer interface [polypeptide binding]; other site 330214007244 active site 330214007245 SAM binding site [chemical binding]; other site 330214007246 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 330214007247 CPxP motif; other site 330214007248 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 330214007249 Bifunctional nuclease; Region: DNase-RNase; pfam02577 330214007250 Bifunctional nuclease; Region: DNase-RNase; pfam02577 330214007251 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 330214007252 23S rRNA interface [nucleotide binding]; other site 330214007253 L3 interface [polypeptide binding]; other site 330214007254 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 330214007255 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 330214007256 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 330214007257 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 330214007258 heterotetramer interface [polypeptide binding]; other site 330214007259 active site pocket [active] 330214007260 cleavage site 330214007261 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 330214007262 rRNA interaction site [nucleotide binding]; other site 330214007263 S8 interaction site; other site 330214007264 putative laminin-1 binding site; other site 330214007265 elongation factor Ts; Reviewed; Region: tsf; PRK12332 330214007266 UBA/TS-N domain; Region: UBA; pfam00627 330214007267 Elongation factor TS; Region: EF_TS; pfam00889 330214007268 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 330214007269 putative nucleotide binding site [chemical binding]; other site 330214007270 uridine monophosphate binding site [chemical binding]; other site 330214007271 homohexameric interface [polypeptide binding]; other site 330214007272 ribosome recycling factor; Reviewed; Region: frr; PRK00083 330214007273 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 330214007274 hinge region; other site 330214007275 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 330214007276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 330214007277 active site 330214007278 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 330214007279 dimer interface [polypeptide binding]; other site 330214007280 substrate binding site [chemical binding]; other site 330214007281 catalytic residues [active] 330214007282 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 330214007283 Domain of unknown function DUF77; Region: DUF77; pfam01910 330214007284 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 330214007285 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 330214007286 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 330214007287 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 330214007288 active site 330214007289 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 330214007290 iron-sulfur cluster [ion binding]; other site 330214007291 [2Fe-2S] cluster binding site [ion binding]; other site 330214007292 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 330214007293 putative active site pocket [active] 330214007294 dimerization interface [polypeptide binding]; other site 330214007295 putative catalytic residue [active] 330214007296 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 330214007297 dimer interface [polypeptide binding]; other site 330214007298 [2Fe-2S] cluster binding site [ion binding]; other site 330214007299 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 330214007300 MPT binding site; other site 330214007301 trimer interface [polypeptide binding]; other site 330214007302 FOG: CBS domain [General function prediction only]; Region: COG0517 330214007303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214007304 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 330214007305 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 330214007306 putative NAD(P) binding site [chemical binding]; other site 330214007307 structural Zn binding site [ion binding]; other site 330214007308 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 330214007309 Radical SAM superfamily; Region: Radical_SAM; pfam04055 330214007310 B12 binding domain; Region: B12-binding; pfam02310 330214007311 B12 binding site [chemical binding]; other site 330214007312 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 330214007313 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 330214007314 B12 binding site [chemical binding]; other site 330214007315 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 330214007316 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 330214007317 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 330214007318 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 330214007319 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 330214007320 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 330214007321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007322 S-adenosylmethionine binding site [chemical binding]; other site 330214007323 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 330214007324 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 330214007325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007326 S-adenosylmethionine binding site [chemical binding]; other site 330214007327 Cupin; Region: Cupin_6; pfam12852 330214007328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 330214007329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 330214007330 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 330214007331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 330214007332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 330214007333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 330214007334 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 330214007335 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 330214007336 trimer interface [polypeptide binding]; other site 330214007337 active site 330214007338 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 330214007339 putative hydrophobic ligand binding site [chemical binding]; other site 330214007340 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 330214007341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 330214007342 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 330214007343 putative substrate binding pocket [chemical binding]; other site 330214007344 putative dimerization interface [polypeptide binding]; other site 330214007345 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 330214007346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 330214007347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214007348 putative substrate translocation pore; other site 330214007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214007350 pyruvate kinase; Provisional; Region: PRK05826 330214007351 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 330214007352 domain interfaces; other site 330214007353 active site 330214007354 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 330214007355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214007356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214007357 DNA binding residues [nucleotide binding] 330214007358 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 330214007359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214007360 putative metal binding site [ion binding]; other site 330214007361 RibD C-terminal domain; Region: RibD_C; cl17279 330214007362 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 330214007363 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214007364 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 330214007365 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 330214007366 active site residue [active] 330214007367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214007368 Response regulator receiver domain; Region: Response_reg; pfam00072 330214007369 active site 330214007370 phosphorylation site [posttranslational modification] 330214007371 intermolecular recognition site; other site 330214007372 dimerization interface [polypeptide binding]; other site 330214007373 HDOD domain; Region: HDOD; pfam08668 330214007374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214007375 Zn2+ binding site [ion binding]; other site 330214007376 Mg2+ binding site [ion binding]; other site 330214007377 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 330214007378 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 330214007379 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 330214007380 putative catalytic cysteine [active] 330214007381 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 330214007382 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 330214007383 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 330214007384 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 330214007385 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 330214007386 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 330214007387 Walker A motif; other site 330214007388 ATP binding site [chemical binding]; other site 330214007389 Walker B motif; other site 330214007390 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 330214007391 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 330214007392 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 330214007393 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 330214007394 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 330214007395 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 330214007396 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 330214007397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214007398 binding surface 330214007399 TPR repeat; Region: TPR_11; pfam13414 330214007400 TPR motif; other site 330214007401 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 330214007402 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 330214007403 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 330214007404 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 330214007405 dockerin binding interface; other site 330214007406 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 330214007407 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 330214007408 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 330214007409 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 330214007410 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 330214007411 Transposase domain (DUF772); Region: DUF772; pfam05598 330214007412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 330214007413 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 330214007414 Integrase core domain; Region: rve; pfam00665 330214007415 transposase/IS protein; Provisional; Region: PRK09183 330214007416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214007417 Walker A motif; other site 330214007418 ATP binding site [chemical binding]; other site 330214007419 Walker B motif; other site 330214007420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 330214007421 Integrase core domain; Region: rve; pfam00665 330214007422 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 330214007423 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 330214007424 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 330214007425 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 330214007426 putative active site [active] 330214007427 putative NTP binding site [chemical binding]; other site 330214007428 putative nucleic acid binding site [nucleotide binding]; other site 330214007429 HTH-like domain; Region: HTH_21; pfam13276 330214007430 Integrase core domain; Region: rve_3; pfam13683 330214007431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007432 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214007433 S-adenosylmethionine binding site [chemical binding]; other site 330214007434 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214007435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007436 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007437 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 330214007438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007439 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007440 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007441 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 330214007442 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 330214007443 O-Antigen ligase; Region: Wzy_C; cl04850 330214007444 Homeodomain-like domain; Region: HTH_23; pfam13384 330214007445 Winged helix-turn helix; Region: HTH_29; pfam13551 330214007446 Homeodomain-like domain; Region: HTH_32; pfam13565 330214007447 DDE superfamily endonuclease; Region: DDE_3; pfam13358 330214007448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 330214007449 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214007450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007451 S-adenosylmethionine binding site [chemical binding]; other site 330214007452 Low molecular weight phosphatase family; Region: LMWPc; cd00115 330214007453 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 330214007454 active site 330214007455 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 330214007456 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 330214007457 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 330214007458 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 330214007459 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 330214007460 putative active site [active] 330214007461 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 330214007462 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 330214007463 DXD motif; other site 330214007464 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 330214007465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 330214007466 catalytic residue [active] 330214007467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 330214007468 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214007469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007470 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 330214007471 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 330214007472 active site 330214007473 dimer interface [polypeptide binding]; other site 330214007474 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 330214007475 Ligand Binding Site [chemical binding]; other site 330214007476 Molecular Tunnel; other site 330214007477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214007478 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 330214007479 NAD binding site [chemical binding]; other site 330214007480 putative substrate binding site 2 [chemical binding]; other site 330214007481 putative substrate binding site 1 [chemical binding]; other site 330214007482 active site 330214007483 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 330214007484 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 330214007485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007486 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007487 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214007488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214007489 active site 330214007490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007491 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007492 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 330214007493 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 330214007494 NAD binding site [chemical binding]; other site 330214007495 homotetramer interface [polypeptide binding]; other site 330214007496 homodimer interface [polypeptide binding]; other site 330214007497 active site 330214007498 substrate binding site [chemical binding]; other site 330214007499 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 330214007500 active site 330214007501 oxyanion hole [active] 330214007502 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214007503 catalytic triad [active] 330214007504 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 330214007505 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214007506 catalytic triad [active] 330214007507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214007509 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 330214007510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214007511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214007512 NAD(P) binding site [chemical binding]; other site 330214007513 active site 330214007514 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 330214007515 M28 Zn-Peptidases; Region: M28_like_3; cd05644 330214007516 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 330214007517 active site 330214007518 metal binding site [ion binding]; metal-binding site 330214007519 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 330214007520 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214007521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007522 S-adenosylmethionine binding site [chemical binding]; other site 330214007523 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 330214007524 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 330214007525 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 330214007526 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 330214007527 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 330214007528 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214007529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214007530 NAD(P) binding site [chemical binding]; other site 330214007531 active site 330214007532 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 330214007533 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 330214007534 substrate binding site; other site 330214007535 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 330214007536 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 330214007537 Walker A/P-loop; other site 330214007538 ATP binding site [chemical binding]; other site 330214007539 Q-loop/lid; other site 330214007540 ABC transporter signature motif; other site 330214007541 Walker B; other site 330214007542 D-loop; other site 330214007543 H-loop/switch region; other site 330214007544 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 330214007545 putative carbohydrate binding site [chemical binding]; other site 330214007546 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 330214007547 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 330214007548 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 330214007549 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 330214007550 putative active site [active] 330214007551 putative catalytic site [active] 330214007552 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 330214007553 Bacterial sugar transferase; Region: Bac_transf; pfam02397 330214007554 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 330214007555 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 330214007556 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 330214007557 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214007558 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 330214007559 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214007560 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 330214007561 SLBB domain; Region: SLBB; pfam10531 330214007562 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 330214007563 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 330214007564 SLBB domain; Region: SLBB; pfam10531 330214007565 PilZ domain; Region: PilZ; pfam07238 330214007566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214007567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214007568 DNA binding residues [nucleotide binding] 330214007569 dimerization interface [polypeptide binding]; other site 330214007570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 330214007571 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 330214007572 PYR/PP interface [polypeptide binding]; other site 330214007573 dimer interface [polypeptide binding]; other site 330214007574 TPP binding site [chemical binding]; other site 330214007575 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 330214007576 TPP-binding site; other site 330214007577 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 330214007578 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 330214007579 tetramer interface [polypeptide binding]; other site 330214007580 active site 330214007581 Mg2+/Mn2+ binding site [ion binding]; other site 330214007582 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 330214007583 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 330214007584 active site 330214007585 metal-binding site 330214007586 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 330214007587 glycogen synthase; Provisional; Region: glgA; PRK00654 330214007588 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 330214007589 ADP-binding pocket [chemical binding]; other site 330214007590 homodimer interface [polypeptide binding]; other site 330214007591 Protein of unknown function (DUF971); Region: DUF971; pfam06155 330214007592 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 330214007593 Recombination protein O N terminal; Region: RecO_N; pfam11967 330214007594 Recombination protein O C terminal; Region: RecO_C; pfam02565 330214007595 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 330214007596 MgtE intracellular N domain; Region: MgtE_N; smart00924 330214007597 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 330214007598 Divalent cation transporter; Region: MgtE; pfam01769 330214007599 GTPase Era; Reviewed; Region: era; PRK00089 330214007600 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 330214007601 G1 box; other site 330214007602 GTP/Mg2+ binding site [chemical binding]; other site 330214007603 Switch I region; other site 330214007604 G2 box; other site 330214007605 Switch II region; other site 330214007606 G3 box; other site 330214007607 G4 box; other site 330214007608 G5 box; other site 330214007609 KH domain; Region: KH_2; pfam07650 330214007610 Septum formation initiator; Region: DivIC; pfam04977 330214007611 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 330214007612 enolase; Provisional; Region: eno; PRK00077 330214007613 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 330214007614 dimer interface [polypeptide binding]; other site 330214007615 metal binding site [ion binding]; metal-binding site 330214007616 substrate binding pocket [chemical binding]; other site 330214007617 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 330214007618 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 330214007619 GatB domain; Region: GatB_Yqey; smart00845 330214007620 YtxH-like protein; Region: YtxH; pfam12732 330214007621 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 330214007622 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 330214007623 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 330214007624 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 330214007625 tetramerization interface [polypeptide binding]; other site 330214007626 active site 330214007627 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 330214007628 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 330214007629 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 330214007630 glutaminase active site [active] 330214007631 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 330214007632 dimer interface [polypeptide binding]; other site 330214007633 active site 330214007634 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 330214007635 dimer interface [polypeptide binding]; other site 330214007636 active site 330214007637 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 330214007638 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 330214007639 Substrate binding site; other site 330214007640 Mg++ binding site; other site 330214007641 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 330214007642 active site 330214007643 substrate binding site [chemical binding]; other site 330214007644 CoA binding site [chemical binding]; other site 330214007645 Uncharacterized conserved protein [Function unknown]; Region: COG2928 330214007646 thymidylate kinase; Validated; Region: tmk; PRK00698 330214007647 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 330214007648 TMP-binding site; other site 330214007649 ATP-binding site [chemical binding]; other site 330214007650 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 330214007651 DNA polymerase III subunit delta'; Validated; Region: PRK08485 330214007652 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 330214007653 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 330214007654 active site 330214007655 HIGH motif; other site 330214007656 KMSKS motif; other site 330214007657 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 330214007658 tRNA binding surface [nucleotide binding]; other site 330214007659 anticodon binding site; other site 330214007660 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 330214007661 dimer interface [polypeptide binding]; other site 330214007662 putative tRNA-binding site [nucleotide binding]; other site 330214007663 FtsH Extracellular; Region: FtsH_ext; pfam06480 330214007664 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 330214007665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214007666 Walker A motif; other site 330214007667 ATP binding site [chemical binding]; other site 330214007668 Walker B motif; other site 330214007669 arginine finger; other site 330214007670 Peptidase family M41; Region: Peptidase_M41; pfam01434 330214007671 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 330214007672 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 330214007673 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 330214007674 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214007675 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 330214007676 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 330214007677 active site 330214007678 YcfA-like protein; Region: YcfA; cl00752 330214007679 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 330214007680 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 330214007681 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 330214007682 Fic/DOC family; Region: Fic; cl00960 330214007683 Transposase IS200 like; Region: Y1_Tnp; cl00848 330214007684 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 330214007685 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 330214007686 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 330214007687 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 330214007688 putative active site [active] 330214007689 catalytic site [active] 330214007690 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 330214007691 Fic family protein [Function unknown]; Region: COG3177 330214007692 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 330214007693 Fic/DOC family; Region: Fic; pfam02661 330214007694 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 330214007695 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 330214007696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 330214007697 putative DNA binding site [nucleotide binding]; other site 330214007698 putative Zn2+ binding site [ion binding]; other site 330214007699 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214007700 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214007701 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214007702 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 330214007703 Gram-negative bacterial tonB protein; Region: TonB; cl10048 330214007704 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 330214007705 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 330214007706 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 330214007707 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 330214007708 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 330214007709 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 330214007710 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 330214007711 active site 330214007712 YacP-like NYN domain; Region: NYN_YacP; pfam05991 330214007713 AMIN domain; Region: AMIN; pfam11741 330214007714 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 330214007715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 330214007716 active site 330214007717 metal binding site [ion binding]; metal-binding site 330214007718 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 330214007719 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 330214007720 dimerization interface 3.5A [polypeptide binding]; other site 330214007721 active site 330214007722 psiF repeat; Region: PsiF_repeat; pfam07769 330214007723 psiF repeat; Region: PsiF_repeat; pfam07769 330214007724 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 330214007725 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 330214007726 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 330214007727 trimer interface [polypeptide binding]; other site 330214007728 active site 330214007729 substrate binding site [chemical binding]; other site 330214007730 CoA binding site [chemical binding]; other site 330214007731 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 330214007732 homotrimer interaction site [polypeptide binding]; other site 330214007733 zinc binding site [ion binding]; other site 330214007734 CDP-binding sites; other site 330214007735 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 330214007736 substrate binding site; other site 330214007737 dimer interface; other site 330214007738 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 330214007739 putative active site [active] 330214007740 TRAM domain; Region: TRAM; cl01282 330214007741 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 330214007742 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214007743 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214007744 protein binding site [polypeptide binding]; other site 330214007745 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214007746 protein binding site [polypeptide binding]; other site 330214007747 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 330214007748 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 330214007749 putative active site; other site 330214007750 catalytic residue [active] 330214007751 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 330214007752 AMP binding site [chemical binding]; other site 330214007753 metal binding site [ion binding]; metal-binding site 330214007754 active site 330214007755 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 330214007756 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 330214007757 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 330214007758 active site 330214007759 substrate binding site [chemical binding]; other site 330214007760 metal binding site [ion binding]; metal-binding site 330214007761 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 330214007762 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 330214007763 Substrate binding site; other site 330214007764 Cupin domain; Region: Cupin_2; cl17218 330214007765 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 330214007766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214007767 active site 330214007768 motif I; other site 330214007769 motif II; other site 330214007770 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 330214007771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214007772 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 330214007773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007774 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 330214007775 putative ADP-binding pocket [chemical binding]; other site 330214007776 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007777 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 330214007778 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 330214007779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007780 putative homodimer interface [polypeptide binding]; other site 330214007781 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214007782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007783 S-adenosylmethionine binding site [chemical binding]; other site 330214007784 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214007785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007787 S-adenosylmethionine binding site [chemical binding]; other site 330214007788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007789 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 330214007790 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 330214007791 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 330214007792 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 330214007793 dimer interface [polypeptide binding]; other site 330214007794 active site 330214007795 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 330214007796 Ligand Binding Site [chemical binding]; other site 330214007797 Molecular Tunnel; other site 330214007798 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 330214007799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214007800 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214007801 NAD(P) binding site [chemical binding]; other site 330214007802 active site 330214007803 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 330214007804 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 330214007805 active site 330214007806 homodimer interface [polypeptide binding]; other site 330214007807 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 330214007808 NeuB family; Region: NeuB; pfam03102 330214007809 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 330214007810 NeuB binding interface [polypeptide binding]; other site 330214007811 putative substrate binding site [chemical binding]; other site 330214007812 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 330214007813 ligand binding site; other site 330214007814 tetramer interface; other site 330214007815 DNA polymerase IV; Provisional; Region: PRK14133 330214007816 Methyltransferase domain; Region: Methyltransf_24; pfam13578 330214007817 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 330214007818 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214007819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 330214007820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214007821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 330214007822 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 330214007823 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214007824 Methyltransferase domain; Region: Methyltransf_12; pfam08242 330214007825 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 330214007826 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 330214007827 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 330214007828 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 330214007829 ligand-binding site [chemical binding]; other site 330214007830 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 330214007831 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 330214007832 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 330214007833 dimer interface [polypeptide binding]; other site 330214007834 active site 330214007835 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 330214007836 Ligand Binding Site [chemical binding]; other site 330214007837 Molecular Tunnel; other site 330214007838 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 330214007839 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 330214007840 NADP binding site [chemical binding]; other site 330214007841 active site 330214007842 putative substrate binding site [chemical binding]; other site 330214007843 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 330214007844 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 330214007845 NADP-binding site; other site 330214007846 homotetramer interface [polypeptide binding]; other site 330214007847 substrate binding site [chemical binding]; other site 330214007848 homodimer interface [polypeptide binding]; other site 330214007849 active site 330214007850 O-Antigen ligase; Region: Wzy_C; pfam04932 330214007851 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 330214007852 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 330214007853 NADP binding site [chemical binding]; other site 330214007854 active site 330214007855 putative substrate binding site [chemical binding]; other site 330214007856 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 330214007857 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 330214007858 NAD binding site [chemical binding]; other site 330214007859 substrate binding site [chemical binding]; other site 330214007860 homodimer interface [polypeptide binding]; other site 330214007861 active site 330214007862 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 330214007863 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 330214007864 substrate binding site; other site 330214007865 tetramer interface; other site 330214007866 Predicted dehydrogenase [General function prediction only]; Region: COG0579 330214007867 hydroxyglutarate oxidase; Provisional; Region: PRK11728 330214007868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007869 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 330214007870 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214007871 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 330214007872 active site 330214007873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214007874 binding surface 330214007875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214007876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214007877 S-adenosylmethionine binding site [chemical binding]; other site 330214007878 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214007879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214007880 active site 330214007881 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214007882 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214007883 putative active site [active] 330214007884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007885 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 330214007886 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214007887 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 330214007888 putative metal binding site; other site 330214007889 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 330214007890 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214007891 putative metal binding site; other site 330214007892 Sulfatase; Region: Sulfatase; pfam00884 330214007893 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214007894 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 330214007895 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214007896 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214007897 putative active site [active] 330214007898 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214007899 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214007900 putative active site [active] 330214007901 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 330214007902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214007903 active site 330214007904 motif I; other site 330214007905 motif II; other site 330214007906 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 330214007907 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 330214007908 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 330214007909 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 330214007910 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 330214007911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 330214007912 putative acyl-acceptor binding pocket; other site 330214007913 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 330214007914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 330214007915 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 330214007916 Walker A/P-loop; other site 330214007917 ATP binding site [chemical binding]; other site 330214007918 Q-loop/lid; other site 330214007919 ABC transporter signature motif; other site 330214007920 Walker B; other site 330214007921 D-loop; other site 330214007922 H-loop/switch region; other site 330214007923 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 330214007924 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 330214007925 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 330214007926 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214007927 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 330214007928 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 330214007929 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 330214007930 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 330214007931 active site 330214007932 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 330214007933 periplasmic chaperone; Provisional; Region: PRK10780 330214007934 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 330214007935 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 330214007936 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 330214007937 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 330214007938 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 330214007939 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 330214007940 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 330214007941 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 330214007942 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214007943 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 330214007944 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 330214007945 active site 330214007946 tetramer interface; other site 330214007947 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 330214007948 Found in ATP-dependent protease La (LON); Region: LON; smart00464 330214007949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214007950 Walker A motif; other site 330214007951 ATP binding site [chemical binding]; other site 330214007952 Walker B motif; other site 330214007953 arginine finger; other site 330214007954 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 330214007955 thiamine monophosphate kinase; Provisional; Region: PRK05731 330214007956 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 330214007957 ATP binding site [chemical binding]; other site 330214007958 dimerization interface [polypeptide binding]; other site 330214007959 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 330214007960 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 330214007961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214007962 Zn2+ binding site [ion binding]; other site 330214007963 Mg2+ binding site [ion binding]; other site 330214007964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214007965 PAS domain; Region: PAS_9; pfam13426 330214007966 putative active site [active] 330214007967 heme pocket [chemical binding]; other site 330214007968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214007969 PAS fold; Region: PAS_3; pfam08447 330214007970 putative active site [active] 330214007971 heme pocket [chemical binding]; other site 330214007972 PAS domain S-box; Region: sensory_box; TIGR00229 330214007973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214007974 putative active site [active] 330214007975 heme pocket [chemical binding]; other site 330214007976 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214007977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214007978 putative active site [active] 330214007979 heme pocket [chemical binding]; other site 330214007980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214007981 dimer interface [polypeptide binding]; other site 330214007982 phosphorylation site [posttranslational modification] 330214007983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214007984 ATP binding site [chemical binding]; other site 330214007985 Mg2+ binding site [ion binding]; other site 330214007986 G-X-G motif; other site 330214007987 Response regulator receiver domain; Region: Response_reg; pfam00072 330214007988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214007989 active site 330214007990 phosphorylation site [posttranslational modification] 330214007991 intermolecular recognition site; other site 330214007992 dimerization interface [polypeptide binding]; other site 330214007993 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214007994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214007995 active site 330214007996 phosphorylation site [posttranslational modification] 330214007997 intermolecular recognition site; other site 330214007998 dimerization interface [polypeptide binding]; other site 330214007999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008000 PAS fold; Region: PAS_3; pfam08447 330214008001 putative active site [active] 330214008002 heme pocket [chemical binding]; other site 330214008003 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214008004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214008005 dimer interface [polypeptide binding]; other site 330214008006 phosphorylation site [posttranslational modification] 330214008007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008008 ATP binding site [chemical binding]; other site 330214008009 Mg2+ binding site [ion binding]; other site 330214008010 G-X-G motif; other site 330214008011 Response regulator receiver domain; Region: Response_reg; pfam00072 330214008012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008013 active site 330214008014 phosphorylation site [posttranslational modification] 330214008015 intermolecular recognition site; other site 330214008016 dimerization interface [polypeptide binding]; other site 330214008017 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 330214008018 Peptidase family M23; Region: Peptidase_M23; pfam01551 330214008019 Pup-ligase protein; Region: Pup_ligase; pfam03136 330214008020 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 330214008021 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 330214008022 active site 330214008023 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 330214008024 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 330214008025 active site 330214008026 Pup-ligase protein; Region: Pup_ligase; pfam03136 330214008027 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 330214008028 proteasome ATPase; Region: pup_AAA; TIGR03689 330214008029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008030 Walker A motif; other site 330214008031 ATP binding site [chemical binding]; other site 330214008032 Walker B motif; other site 330214008033 arginine finger; other site 330214008034 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 330214008035 thiamine phosphate binding site [chemical binding]; other site 330214008036 active site 330214008037 pyrophosphate binding site [ion binding]; other site 330214008038 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 330214008039 ThiS interaction site; other site 330214008040 putative active site [active] 330214008041 tetramer interface [polypeptide binding]; other site 330214008042 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 330214008043 thiS-thiF/thiG interaction site; other site 330214008044 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 330214008045 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 330214008046 C-terminal peptidase (prc); Region: prc; TIGR00225 330214008047 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 330214008048 protein binding site [polypeptide binding]; other site 330214008049 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 330214008050 Catalytic dyad [active] 330214008051 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 330214008052 Peptidase family M23; Region: Peptidase_M23; pfam01551 330214008053 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 330214008054 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 330214008055 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 330214008056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214008057 Walker A/P-loop; other site 330214008058 ATP binding site [chemical binding]; other site 330214008059 Q-loop/lid; other site 330214008060 ABC transporter signature motif; other site 330214008061 Walker B; other site 330214008062 D-loop; other site 330214008063 H-loop/switch region; other site 330214008064 hypothetical protein; Reviewed; Region: PRK12497 330214008065 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 330214008066 RNA/DNA hybrid binding site [nucleotide binding]; other site 330214008067 active site 330214008068 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 330214008069 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 330214008070 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 330214008071 RimM N-terminal domain; Region: RimM; pfam01782 330214008072 ribosomal protein S16; Region: S16; TIGR00002 330214008073 signal recognition particle protein; Provisional; Region: PRK10867 330214008074 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 330214008075 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 330214008076 P loop; other site 330214008077 GTP binding site [chemical binding]; other site 330214008078 Signal peptide binding domain; Region: SRP_SPB; pfam02978 330214008079 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 330214008080 excinuclease ABC subunit B; Provisional; Region: PRK05298 330214008081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214008082 ATP binding site [chemical binding]; other site 330214008083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214008084 nucleotide binding region [chemical binding]; other site 330214008085 ATP-binding site [chemical binding]; other site 330214008086 Ultra-violet resistance protein B; Region: UvrB; pfam12344 330214008087 UvrB/uvrC motif; Region: UVR; pfam02151 330214008088 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 330214008089 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 330214008090 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 330214008091 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 330214008092 competence damage-inducible protein A; Provisional; Region: PRK00549 330214008093 putative MPT binding site; other site 330214008094 Competence-damaged protein; Region: CinA; pfam02464 330214008095 Chlorite dismutase; Region: Chlor_dismutase; cl01280 330214008096 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 330214008097 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 330214008098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 330214008099 Peptidase M15; Region: Peptidase_M15_3; cl01194 330214008100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008101 active site 330214008102 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 330214008103 phosphorylation site [posttranslational modification] 330214008104 intermolecular recognition site; other site 330214008105 dimerization interface [polypeptide binding]; other site 330214008106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008107 Walker A motif; other site 330214008108 ATP binding site [chemical binding]; other site 330214008109 Walker B motif; other site 330214008110 arginine finger; other site 330214008111 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214008112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214008113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008114 active site 330214008115 phosphorylation site [posttranslational modification] 330214008116 intermolecular recognition site; other site 330214008117 dimerization interface [polypeptide binding]; other site 330214008118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214008119 DNA binding residues [nucleotide binding] 330214008120 dimerization interface [polypeptide binding]; other site 330214008121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008122 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214008123 putative active site [active] 330214008124 heme pocket [chemical binding]; other site 330214008125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008126 putative active site [active] 330214008127 heme pocket [chemical binding]; other site 330214008128 PAS domain S-box; Region: sensory_box; TIGR00229 330214008129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008130 putative active site [active] 330214008131 heme pocket [chemical binding]; other site 330214008132 PAS domain S-box; Region: sensory_box; TIGR00229 330214008133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008134 putative active site [active] 330214008135 heme pocket [chemical binding]; other site 330214008136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 330214008137 Histidine kinase; Region: HisKA_3; pfam07730 330214008138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008139 ATP binding site [chemical binding]; other site 330214008140 Mg2+ binding site [ion binding]; other site 330214008141 G-X-G motif; other site 330214008142 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 330214008143 active site 330214008144 Ap6A binding site [chemical binding]; other site 330214008145 nudix motif; other site 330214008146 metal binding site [ion binding]; metal-binding site 330214008147 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 330214008148 short chain dehydrogenase; Provisional; Region: PRK06914 330214008149 NADP binding site [chemical binding]; other site 330214008150 active site 330214008151 steroid binding site; other site 330214008152 Archaeal serine proteases [General function prediction only]; Region: COG1750 330214008153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214008154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008155 binding surface 330214008156 TPR motif; other site 330214008157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214008158 CHAT domain; Region: CHAT; cl17868 330214008159 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 330214008160 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 330214008161 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 330214008162 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 330214008163 Surface antigen; Region: Bac_surface_Ag; pfam01103 330214008164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 330214008165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 330214008166 active site 330214008167 Patatin-like phospholipase; Region: Patatin; pfam01734 330214008168 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 330214008169 enoyl-CoA hydratase; Provisional; Region: PRK07658 330214008170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 330214008171 substrate binding site [chemical binding]; other site 330214008172 oxyanion hole (OAH) forming residues; other site 330214008173 trimer interface [polypeptide binding]; other site 330214008174 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 330214008175 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 330214008176 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 330214008177 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 330214008178 putative acyltransferase; Provisional; Region: PRK05790 330214008179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 330214008180 dimer interface [polypeptide binding]; other site 330214008181 active site 330214008182 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 330214008183 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 330214008184 acyl-activating enzyme (AAE) consensus motif; other site 330214008185 putative AMP binding site [chemical binding]; other site 330214008186 putative active site [active] 330214008187 putative CoA binding site [chemical binding]; other site 330214008188 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 330214008189 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 330214008190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214008191 active site 330214008192 metal binding site [ion binding]; metal-binding site 330214008193 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 330214008194 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 330214008195 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 330214008196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 330214008197 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 330214008198 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 330214008199 tetramer interface [polypeptide binding]; other site 330214008200 TPP-binding site [chemical binding]; other site 330214008201 heterodimer interface [polypeptide binding]; other site 330214008202 phosphorylation loop region [posttranslational modification] 330214008203 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 330214008204 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 330214008205 alpha subunit interface [polypeptide binding]; other site 330214008206 TPP binding site [chemical binding]; other site 330214008207 heterodimer interface [polypeptide binding]; other site 330214008208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214008209 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 330214008210 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 330214008211 E3 interaction surface; other site 330214008212 lipoyl attachment site [posttranslational modification]; other site 330214008213 e3 binding domain; Region: E3_binding; pfam02817 330214008214 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 330214008215 putative acyltransferase; Provisional; Region: PRK05790 330214008216 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 330214008217 dimer interface [polypeptide binding]; other site 330214008218 active site 330214008219 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 330214008220 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 330214008221 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 330214008222 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 330214008223 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 330214008224 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 330214008225 B12 binding site [chemical binding]; other site 330214008226 cobalt ligand [ion binding]; other site 330214008227 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 330214008228 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 330214008229 enoyl-CoA hydratase; Provisional; Region: PRK05995 330214008230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 330214008231 substrate binding site [chemical binding]; other site 330214008232 oxyanion hole (OAH) forming residues; other site 330214008233 trimer interface [polypeptide binding]; other site 330214008234 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 330214008235 active site 330214008236 catalytic residues [active] 330214008237 metal binding site [ion binding]; metal-binding site 330214008238 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 330214008239 Walker A; other site 330214008240 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 330214008241 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 330214008242 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 330214008243 tetramer interface [polypeptide binding]; other site 330214008244 active site 330214008245 Mg2+/Mn2+ binding site [ion binding]; other site 330214008246 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 330214008247 Citrate synthase; Region: Citrate_synt; pfam00285 330214008248 oxalacetate binding site [chemical binding]; other site 330214008249 citrylCoA binding site [chemical binding]; other site 330214008250 coenzyme A binding site [chemical binding]; other site 330214008251 catalytic triad [active] 330214008252 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 330214008253 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 330214008254 acyl-activating enzyme (AAE) consensus motif; other site 330214008255 AMP binding site [chemical binding]; other site 330214008256 active site 330214008257 CoA binding site [chemical binding]; other site 330214008258 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 330214008259 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 330214008260 active site 330214008261 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 330214008262 Mechanosensitive ion channel; Region: MS_channel; pfam00924 330214008263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008264 binding surface 330214008265 TPR motif; other site 330214008266 TPR repeat; Region: TPR_11; pfam13414 330214008267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008268 binding surface 330214008269 TPR motif; other site 330214008270 TPR repeat; Region: TPR_11; pfam13414 330214008271 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 330214008272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008273 TPR motif; other site 330214008274 binding surface 330214008275 TPR repeat; Region: TPR_11; pfam13414 330214008276 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 330214008277 Cadherin repeat-like domain; Region: CA_like; cl15786 330214008278 Ca2+ binding site [ion binding]; other site 330214008279 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008280 Ca2+ binding site [ion binding]; other site 330214008281 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008282 Ca2+ binding site [ion binding]; other site 330214008283 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008284 Ca2+ binding site [ion binding]; other site 330214008285 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008286 Ca2+ binding site [ion binding]; other site 330214008287 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008288 Ca2+ binding site [ion binding]; other site 330214008289 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008290 Ca2+ binding site [ion binding]; other site 330214008291 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 330214008292 Ca2+ binding site [ion binding]; other site 330214008293 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 330214008294 active site 330214008295 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214008296 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214008297 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214008298 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214008299 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214008300 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214008301 Outer membrane efflux protein; Region: OEP; pfam02321 330214008302 Outer membrane efflux protein; Region: OEP; pfam02321 330214008303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214008304 non-specific DNA binding site [nucleotide binding]; other site 330214008305 salt bridge; other site 330214008306 sequence-specific DNA binding site [nucleotide binding]; other site 330214008307 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 330214008308 Catalytic site [active] 330214008309 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 330214008310 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 330214008311 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 330214008312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214008313 Walker A/P-loop; other site 330214008314 ATP binding site [chemical binding]; other site 330214008315 Q-loop/lid; other site 330214008316 ABC transporter signature motif; other site 330214008317 Walker B; other site 330214008318 D-loop; other site 330214008319 H-loop/switch region; other site 330214008320 TOBE domain; Region: TOBE; cl01440 330214008321 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 330214008322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214008323 dimer interface [polypeptide binding]; other site 330214008324 conserved gate region; other site 330214008325 putative PBP binding loops; other site 330214008326 ABC-ATPase subunit interface; other site 330214008327 TOBE domain; Region: TOBE; cl01440 330214008328 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 330214008329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 330214008330 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 330214008331 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 330214008332 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 330214008333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214008334 non-specific DNA binding site [nucleotide binding]; other site 330214008335 salt bridge; other site 330214008336 sequence-specific DNA binding site [nucleotide binding]; other site 330214008337 PBP superfamily domain; Region: PBP_like; pfam12727 330214008338 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 330214008339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 330214008340 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 330214008341 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 330214008342 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 330214008343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214008344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214008345 dimerization interface [polypeptide binding]; other site 330214008346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214008347 dimer interface [polypeptide binding]; other site 330214008348 phosphorylation site [posttranslational modification] 330214008349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008350 ATP binding site [chemical binding]; other site 330214008351 Mg2+ binding site [ion binding]; other site 330214008352 G-X-G motif; other site 330214008353 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214008354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008355 active site 330214008356 phosphorylation site [posttranslational modification] 330214008357 intermolecular recognition site; other site 330214008358 dimerization interface [polypeptide binding]; other site 330214008359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008360 Walker A motif; other site 330214008361 ATP binding site [chemical binding]; other site 330214008362 Walker B motif; other site 330214008363 arginine finger; other site 330214008364 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214008365 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 330214008366 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 330214008367 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 330214008368 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 330214008369 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 330214008370 RNA binding site [nucleotide binding]; other site 330214008371 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 330214008372 potassium uptake protein; Region: kup; TIGR00794 330214008373 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 330214008374 Ferritin-like domain; Region: Ferritin; pfam00210 330214008375 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 330214008376 dinuclear metal binding motif [ion binding]; other site 330214008377 GTP-binding protein YchF; Reviewed; Region: PRK09601 330214008378 YchF GTPase; Region: YchF; cd01900 330214008379 G1 box; other site 330214008380 GTP/Mg2+ binding site [chemical binding]; other site 330214008381 Switch I region; other site 330214008382 G2 box; other site 330214008383 Switch II region; other site 330214008384 G3 box; other site 330214008385 G4 box; other site 330214008386 G5 box; other site 330214008387 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 330214008388 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 330214008389 trimer interface [polypeptide binding]; other site 330214008390 active site 330214008391 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 330214008392 active site 330214008393 UDP-glucose 4-epimerase; Region: PLN02240 330214008394 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 330214008395 NAD binding site [chemical binding]; other site 330214008396 homodimer interface [polypeptide binding]; other site 330214008397 active site 330214008398 substrate binding site [chemical binding]; other site 330214008399 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 330214008400 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 330214008401 HSP70 interaction site [polypeptide binding]; other site 330214008402 ERCC4 domain; Region: ERCC4; cl10594 330214008403 Ycf46; Provisional; Region: ycf46; CHL00195 330214008404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008405 Walker A motif; other site 330214008406 ATP binding site [chemical binding]; other site 330214008407 Walker B motif; other site 330214008408 arginine finger; other site 330214008409 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214008410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008411 binding surface 330214008412 TPR motif; other site 330214008413 TPR repeat; Region: TPR_11; pfam13414 330214008414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008415 TPR motif; other site 330214008416 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214008417 binding surface 330214008418 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 330214008419 active site 330214008420 catalytic residues [active] 330214008421 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 330214008422 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 330214008423 active site 330214008424 ADP/pyrophosphate binding site [chemical binding]; other site 330214008425 dimerization interface [polypeptide binding]; other site 330214008426 allosteric effector site; other site 330214008427 fructose-1,6-bisphosphate binding site; other site 330214008428 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 330214008429 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 330214008430 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 330214008431 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 330214008432 ATP binding site [chemical binding]; other site 330214008433 Mg++ binding site [ion binding]; other site 330214008434 motif III; other site 330214008435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214008436 nucleotide binding region [chemical binding]; other site 330214008437 ATP-binding site [chemical binding]; other site 330214008438 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 330214008439 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 330214008440 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 330214008441 Peptidase family M28; Region: Peptidase_M28; pfam04389 330214008442 metal binding site [ion binding]; metal-binding site 330214008443 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 330214008444 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 330214008445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214008446 H+ Antiporter protein; Region: 2A0121; TIGR00900 330214008447 putative substrate translocation pore; other site 330214008448 BON domain; Region: BON; pfam04972 330214008449 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 330214008450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214008451 H+ Antiporter protein; Region: 2A0121; TIGR00900 330214008452 putative substrate translocation pore; other site 330214008453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214008454 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 330214008455 putative ADP-binding pocket [chemical binding]; other site 330214008456 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 330214008457 ribonuclease Z; Provisional; Region: PRK02126 330214008458 hypothetical protein; Provisional; Region: PRK09272 330214008459 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 330214008460 Mrr N-terminal domain; Region: Mrr_N; pfam14338 330214008461 short chain dehydrogenase; Provisional; Region: PRK07890 330214008462 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 330214008463 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 330214008464 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 330214008465 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 330214008466 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 330214008467 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 330214008468 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 330214008469 Predicted amidohydrolase [General function prediction only]; Region: COG0388 330214008470 Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577 330214008471 putative active site [active] 330214008472 catalytic triad [active] 330214008473 dimer interface [polypeptide binding]; other site 330214008474 putative tetramer interface [polypeptide binding]; other site 330214008475 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 330214008476 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 330214008477 active site residue [active] 330214008478 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 330214008479 active site residue [active] 330214008480 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 330214008481 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 330214008482 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 330214008483 active site 330214008484 Zn binding site [ion binding]; other site 330214008485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008486 TPR repeat; Region: TPR_11; pfam13414 330214008487 TPR motif; other site 330214008488 binding surface 330214008489 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 330214008490 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 330214008491 active site 330214008492 Zn binding site [ion binding]; other site 330214008493 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 330214008494 Response regulator receiver domain; Region: Response_reg; pfam00072 330214008495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008496 active site 330214008497 phosphorylation site [posttranslational modification] 330214008498 intermolecular recognition site; other site 330214008499 dimerization interface [polypeptide binding]; other site 330214008500 FOG: CBS domain [General function prediction only]; Region: COG0517 330214008501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 330214008502 Uncharacterized conserved protein [Function unknown]; Region: COG3189 330214008503 CHASE3 domain; Region: CHASE3; pfam05227 330214008504 DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478 330214008505 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 330214008506 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214008507 molybdopterin cofactor binding site; other site 330214008508 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214008509 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 330214008510 molybdopterin cofactor binding site; other site 330214008511 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 330214008512 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214008513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008514 Walker A motif; other site 330214008515 ATP binding site [chemical binding]; other site 330214008516 Walker B motif; other site 330214008517 arginine finger; other site 330214008518 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 330214008519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214008520 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 330214008521 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 330214008522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214008523 putative substrate translocation pore; other site 330214008524 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 330214008525 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 330214008526 CHASE3 domain; Region: CHASE3; pfam05227 330214008527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008528 PAS domain; Region: PAS_9; pfam13426 330214008529 putative active site [active] 330214008530 heme pocket [chemical binding]; other site 330214008531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214008532 dimer interface [polypeptide binding]; other site 330214008533 phosphorylation site [posttranslational modification] 330214008534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008535 ATP binding site [chemical binding]; other site 330214008536 G-X-G motif; other site 330214008537 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214008538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008539 active site 330214008540 phosphorylation site [posttranslational modification] 330214008541 intermolecular recognition site; other site 330214008542 dimerization interface [polypeptide binding]; other site 330214008543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008544 Walker A motif; other site 330214008545 ATP binding site [chemical binding]; other site 330214008546 Walker B motif; other site 330214008547 arginine finger; other site 330214008548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214008549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 330214008550 Histidine kinase; Region: HisKA_3; pfam07730 330214008551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008552 ATP binding site [chemical binding]; other site 330214008553 Mg2+ binding site [ion binding]; other site 330214008554 G-X-G motif; other site 330214008555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214008556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008557 active site 330214008558 phosphorylation site [posttranslational modification] 330214008559 intermolecular recognition site; other site 330214008560 dimerization interface [polypeptide binding]; other site 330214008561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214008562 DNA binding residues [nucleotide binding] 330214008563 dimerization interface [polypeptide binding]; other site 330214008564 Outer membrane efflux protein; Region: OEP; pfam02321 330214008565 Outer membrane efflux protein; Region: OEP; pfam02321 330214008566 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214008567 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214008568 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 330214008569 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 330214008570 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 330214008571 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214008572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008573 active site 330214008574 phosphorylation site [posttranslational modification] 330214008575 intermolecular recognition site; other site 330214008576 dimerization interface [polypeptide binding]; other site 330214008577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008578 Walker A motif; other site 330214008579 ATP binding site [chemical binding]; other site 330214008580 Walker B motif; other site 330214008581 arginine finger; other site 330214008582 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 330214008583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214008584 molybdopterin cofactor binding site; other site 330214008585 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214008586 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 330214008587 molybdopterin cofactor binding site; other site 330214008588 DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478 330214008589 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 330214008590 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 330214008591 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 330214008592 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 330214008593 Mechanosensitive ion channel; Region: MS_channel; pfam00924 330214008594 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 330214008595 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 330214008596 ligand binding site [chemical binding]; other site 330214008597 flexible hinge region; other site 330214008598 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 330214008599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214008600 Zn2+ binding site [ion binding]; other site 330214008601 Mg2+ binding site [ion binding]; other site 330214008602 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 330214008603 synthetase active site [active] 330214008604 NTP binding site [chemical binding]; other site 330214008605 metal binding site [ion binding]; metal-binding site 330214008606 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 330214008607 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 330214008608 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 330214008609 DHH family; Region: DHH; pfam01368 330214008610 DHHA1 domain; Region: DHHA1; pfam02272 330214008611 Pup-like protein; Region: Pup; pfam05639 330214008612 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 330214008613 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 330214008614 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 330214008615 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 330214008616 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214008617 protein binding site [polypeptide binding]; other site 330214008618 Heme-binding domain of bacterial ethylbenzene dehydrogenase; Region: DOMON_EBDH; cd09623 330214008619 heme binding site [chemical binding]; other site 330214008620 beta subunit binding site [polypeptide binding]; other site 330214008621 NHL repeat; Region: NHL; pfam01436 330214008622 NHL repeat; Region: NHL; pfam01436 330214008623 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 330214008624 TPR repeat; Region: TPR_11; pfam13414 330214008625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008626 binding surface 330214008627 TPR motif; other site 330214008628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214008629 TPR repeat; Region: TPR_11; pfam13414 330214008630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008631 binding surface 330214008632 TPR motif; other site 330214008633 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 330214008634 B12 binding site [chemical binding]; other site 330214008635 Radical SAM superfamily; Region: Radical_SAM; pfam04055 330214008636 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 330214008637 putative ligand binding site [chemical binding]; other site 330214008638 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 330214008639 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 330214008640 MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397 330214008641 FOG: WD40 repeat [General function prediction only]; Region: COG2319 330214008642 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 330214008643 structural tetrad; other site 330214008644 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214008645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008646 active site 330214008647 phosphorylation site [posttranslational modification] 330214008648 intermolecular recognition site; other site 330214008649 dimerization interface [polypeptide binding]; other site 330214008650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008651 Walker A motif; other site 330214008652 ATP binding site [chemical binding]; other site 330214008653 Walker B motif; other site 330214008654 arginine finger; other site 330214008655 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214008656 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 330214008657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214008658 dimerization interface [polypeptide binding]; other site 330214008659 PAS domain S-box; Region: sensory_box; TIGR00229 330214008660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008661 putative active site [active] 330214008662 heme pocket [chemical binding]; other site 330214008663 PAS domain S-box; Region: sensory_box; TIGR00229 330214008664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008665 putative active site [active] 330214008666 heme pocket [chemical binding]; other site 330214008667 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 330214008668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214008669 putative active site [active] 330214008670 heme pocket [chemical binding]; other site 330214008671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214008672 dimer interface [polypeptide binding]; other site 330214008673 phosphorylation site [posttranslational modification] 330214008674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008675 ATP binding site [chemical binding]; other site 330214008676 Mg2+ binding site [ion binding]; other site 330214008677 G-X-G motif; other site 330214008678 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 330214008679 Protein export membrane protein; Region: SecD_SecF; cl14618 330214008680 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 330214008681 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 330214008682 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 330214008683 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 330214008684 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 330214008685 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 330214008686 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 330214008687 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 330214008688 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 330214008689 active site 330214008690 HIGH motif; other site 330214008691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 330214008692 KMSK motif region; other site 330214008693 tRNA binding surface [nucleotide binding]; other site 330214008694 DALR anticodon binding domain; Region: DALR_1; smart00836 330214008695 anticodon binding site; other site 330214008696 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 330214008697 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 330214008698 putative active site [active] 330214008699 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 330214008700 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 330214008701 GTP binding site; other site 330214008702 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214008703 Heme-binding domain of bacterial ethylbenzene dehydrogenase; Region: DOMON_EBDH; cd09623 330214008704 heme binding site [chemical binding]; other site 330214008705 beta subunit binding site [polypeptide binding]; other site 330214008706 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214008707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214008708 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 330214008709 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214008710 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214008711 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214008712 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214008713 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 330214008714 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 330214008715 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214008716 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 330214008717 Protein of unknown function (DUF420); Region: DUF420; cl00989 330214008718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214008719 S-adenosylmethionine binding site [chemical binding]; other site 330214008720 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 330214008721 HEAT repeats; Region: HEAT_2; pfam13646 330214008722 HEAT repeats; Region: HEAT_2; pfam13646 330214008723 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 330214008724 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 330214008725 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 330214008726 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 330214008727 HEXXH motif domain; Region: mod_HExxH; TIGR04267 330214008728 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 330214008729 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 330214008730 Domain of unknown function (DUF814); Region: DUF814; pfam05670 330214008731 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214008732 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 330214008733 GAF domain; Region: GAF; pfam01590 330214008734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008735 Walker A motif; other site 330214008736 ATP binding site [chemical binding]; other site 330214008737 Walker B motif; other site 330214008738 arginine finger; other site 330214008739 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214008740 DevC protein; Region: devC; TIGR01185 330214008741 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214008742 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 330214008743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 330214008744 Walker A/P-loop; other site 330214008745 ATP binding site [chemical binding]; other site 330214008746 Q-loop/lid; other site 330214008747 ABC transporter signature motif; other site 330214008748 Walker B; other site 330214008749 D-loop; other site 330214008750 H-loop/switch region; other site 330214008751 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214008752 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 330214008753 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214008754 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 330214008755 TPR repeat; Region: TPR_11; pfam13414 330214008756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008757 binding surface 330214008758 TPR motif; other site 330214008759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008760 binding surface 330214008761 TPR motif; other site 330214008762 TPR repeat; Region: TPR_11; pfam13414 330214008763 TPR repeat; Region: TPR_11; pfam13414 330214008764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008765 binding surface 330214008766 TPR motif; other site 330214008767 Tetratricopeptide repeat; Region: TPR_16; pfam13432 330214008768 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 330214008769 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 330214008770 colanic acid biosynthesis acetyltransferase WcaB; Region: WcaB; TIGR04016 330214008771 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 330214008772 trimer interface [polypeptide binding]; other site 330214008773 active site 330214008774 substrate binding site [chemical binding]; other site 330214008775 CoA binding site [chemical binding]; other site 330214008776 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 330214008777 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 330214008778 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 330214008779 active site 330214008780 catalytic site [active] 330214008781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214008782 glucose-1-dehydrogenase; Provisional; Region: PRK06947 330214008783 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 330214008784 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 330214008785 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 330214008786 Walker A/P-loop; other site 330214008787 ATP binding site [chemical binding]; other site 330214008788 Q-loop/lid; other site 330214008789 ABC transporter signature motif; other site 330214008790 Walker B; other site 330214008791 D-loop; other site 330214008792 H-loop/switch region; other site 330214008793 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 330214008794 putative carbohydrate binding site [chemical binding]; other site 330214008795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214008796 non-specific DNA binding site [nucleotide binding]; other site 330214008797 salt bridge; other site 330214008798 sequence-specific DNA binding site [nucleotide binding]; other site 330214008799 Cupin domain; Region: Cupin_2; pfam07883 330214008800 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 330214008801 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 330214008802 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 330214008803 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 330214008804 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 330214008805 Walker A/P-loop; other site 330214008806 ATP binding site [chemical binding]; other site 330214008807 Q-loop/lid; other site 330214008808 ABC transporter signature motif; other site 330214008809 Walker B; other site 330214008810 D-loop; other site 330214008811 H-loop/switch region; other site 330214008812 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 330214008813 Glycosyl-transferase for dystroglycan; Region: Glyco_transf_49; pfam13896 330214008814 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 330214008815 Walker A motif; other site 330214008816 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 330214008817 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 330214008818 dimer interface [polypeptide binding]; other site 330214008819 putative functional site; other site 330214008820 putative MPT binding site; other site 330214008821 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 330214008822 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 330214008823 Walker A motif; other site 330214008824 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 330214008825 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 330214008826 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214008827 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214008828 protein binding site [polypeptide binding]; other site 330214008829 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 330214008830 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 330214008831 Ligand binding site; other site 330214008832 Ligand binding site; other site 330214008833 Ligand binding site; other site 330214008834 Putative Catalytic site; other site 330214008835 DXD motif; other site 330214008836 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 330214008837 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 330214008838 Cytochrome c; Region: Cytochrom_C; pfam00034 330214008839 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 330214008840 Helix-turn-helix domain; Region: HTH_25; pfam13413 330214008841 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 330214008842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214008843 TPR motif; other site 330214008844 TPR repeat; Region: TPR_11; pfam13414 330214008845 binding surface 330214008846 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 330214008847 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 330214008848 substrate binding site [chemical binding]; other site 330214008849 ATP binding site [chemical binding]; other site 330214008850 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 330214008851 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 330214008852 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 330214008853 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 330214008854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214008855 ATP binding site [chemical binding]; other site 330214008856 Mg2+ binding site [ion binding]; other site 330214008857 G-X-G motif; other site 330214008858 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 330214008859 ATP binding site [chemical binding]; other site 330214008860 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 330214008861 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 330214008862 Tetratricopeptide repeat; Region: TPR_6; pfam13174 330214008863 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 330214008864 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214008865 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 330214008866 ligand binding site [chemical binding]; other site 330214008867 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 330214008868 TolB amino-terminal domain; Region: TolB_N; pfam04052 330214008869 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214008870 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214008871 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214008872 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214008873 TonB C terminal; Region: TonB_2; pfam13103 330214008874 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 330214008875 TolR protein; Region: tolR; TIGR02801 330214008876 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 330214008877 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214008878 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 330214008879 active site 330214008880 DNA binding site [nucleotide binding] 330214008881 Int/Topo IB signature motif; other site 330214008882 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 330214008883 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 330214008884 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 330214008885 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 330214008886 active site 330214008887 HIGH motif; other site 330214008888 dimer interface [polypeptide binding]; other site 330214008889 KMSKS motif; other site 330214008890 PilZ domain; Region: PilZ; pfam07238 330214008891 Bifunctional nuclease; Region: DNase-RNase; pfam02577 330214008892 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 330214008893 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214008894 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214008895 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 330214008896 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 330214008897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214008898 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 330214008899 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 330214008900 active site 330214008901 dimer interface [polypeptide binding]; other site 330214008902 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 330214008903 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 330214008904 active site 330214008905 FMN binding site [chemical binding]; other site 330214008906 substrate binding site [chemical binding]; other site 330214008907 3Fe-4S cluster binding site [ion binding]; other site 330214008908 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 330214008909 domain interface; other site 330214008910 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 330214008911 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 330214008912 substrate binding pocket [chemical binding]; other site 330214008913 chain length determination region; other site 330214008914 substrate-Mg2+ binding site; other site 330214008915 catalytic residues [active] 330214008916 aspartate-rich region 1; other site 330214008917 active site lid residues [active] 330214008918 aspartate-rich region 2; other site 330214008919 Uncharacterized conserved protein [Function unknown]; Region: COG4198 330214008920 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 330214008921 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214008922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214008923 active site 330214008924 phosphorylation site [posttranslational modification] 330214008925 intermolecular recognition site; other site 330214008926 dimerization interface [polypeptide binding]; other site 330214008927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214008928 Walker A motif; other site 330214008929 ATP binding site [chemical binding]; other site 330214008930 Walker B motif; other site 330214008931 arginine finger; other site 330214008932 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214008933 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 330214008934 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 330214008935 Substrate binding site; other site 330214008936 metal-binding site 330214008937 Phosphotransferase enzyme family; Region: APH; pfam01636 330214008938 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 330214008939 active site 330214008940 ATP binding site [chemical binding]; other site 330214008941 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 330214008942 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 330214008943 active site 330214008944 catalytic tetrad [active] 330214008945 VanZ like family; Region: VanZ; cl01971 330214008946 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 330214008947 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 330214008948 putative active site [active] 330214008949 catalytic site [active] 330214008950 ADP-glucose phosphorylase; Region: PLN02643 330214008951 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 330214008952 nucleotide binding site/active site [active] 330214008953 HIT family signature motif; other site 330214008954 catalytic residue [active] 330214008955 Ubiquitin-like proteins; Region: UBQ; cl00155 330214008956 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 330214008957 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 330214008958 Ligand Binding Site [chemical binding]; other site 330214008959 TIGR00269 family protein; Region: TIGR00269 330214008960 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 330214008961 Interdomain contacts; other site 330214008962 Cytokine receptor motif; other site 330214008963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 330214008964 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 330214008965 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 330214008966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214008967 dimer interface [polypeptide binding]; other site 330214008968 conserved gate region; other site 330214008969 putative PBP binding loops; other site 330214008970 ABC-ATPase subunit interface; other site 330214008971 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 330214008972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 330214008973 dimer interface [polypeptide binding]; other site 330214008974 conserved gate region; other site 330214008975 putative PBP binding loops; other site 330214008976 ABC-ATPase subunit interface; other site 330214008977 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 330214008978 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 330214008979 Walker A/P-loop; other site 330214008980 ATP binding site [chemical binding]; other site 330214008981 Q-loop/lid; other site 330214008982 ABC transporter signature motif; other site 330214008983 Walker B; other site 330214008984 D-loop; other site 330214008985 H-loop/switch region; other site 330214008986 TOBE domain; Region: TOBE_2; pfam08402 330214008987 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 330214008988 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 330214008989 HSP70 interaction site [polypeptide binding]; other site 330214008990 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 330214008991 substrate binding site [polypeptide binding]; other site 330214008992 dimer interface [polypeptide binding]; other site 330214008993 MarC family integral membrane protein; Region: MarC; pfam01914 330214008994 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 330214008995 dimer interface [polypeptide binding]; other site 330214008996 Predicted membrane protein [Function unknown]; Region: COG3212 330214008997 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 330214008998 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 330214008999 polyphosphate kinase; Provisional; Region: PRK05443 330214009000 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 330214009001 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 330214009002 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 330214009003 putative active site [active] 330214009004 catalytic site [active] 330214009005 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 330214009006 putative domain interface [polypeptide binding]; other site 330214009007 putative active site [active] 330214009008 catalytic site [active] 330214009009 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 330214009010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009012 binding surface 330214009013 TPR motif; other site 330214009014 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009018 binding surface 330214009019 TPR motif; other site 330214009020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009023 binding surface 330214009024 TPR motif; other site 330214009025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009026 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 330214009027 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 330214009028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214009029 NAD(P) binding site [chemical binding]; other site 330214009030 active site 330214009031 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009033 active site 330214009034 phosphorylation site [posttranslational modification] 330214009035 intermolecular recognition site; other site 330214009036 dimerization interface [polypeptide binding]; other site 330214009037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009038 PAS domain; Region: PAS_9; pfam13426 330214009039 putative active site [active] 330214009040 heme pocket [chemical binding]; other site 330214009041 PAS domain S-box; Region: sensory_box; TIGR00229 330214009042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009043 putative active site [active] 330214009044 heme pocket [chemical binding]; other site 330214009045 PAS domain S-box; Region: sensory_box; TIGR00229 330214009046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009047 putative active site [active] 330214009048 heme pocket [chemical binding]; other site 330214009049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 330214009050 Histidine kinase; Region: HisKA_2; pfam07568 330214009051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009052 ATP binding site [chemical binding]; other site 330214009053 Mg2+ binding site [ion binding]; other site 330214009054 G-X-G motif; other site 330214009055 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 330214009056 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 330214009057 inhibitor-cofactor binding pocket; inhibition site 330214009058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214009059 catalytic residue [active] 330214009060 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 330214009061 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 330214009062 putative ADP-binding pocket [chemical binding]; other site 330214009063 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 330214009064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 330214009065 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655 330214009066 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 330214009067 Mg++ binding site [ion binding]; other site 330214009068 putative catalytic motif [active] 330214009069 substrate binding site [chemical binding]; other site 330214009070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214009071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214009072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214009073 active site 330214009074 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 330214009075 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 330214009076 Probable Catalytic site; other site 330214009077 metal-binding site 330214009078 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 330214009079 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 330214009080 Substrate binding site; other site 330214009081 Mg++ binding site; other site 330214009082 metal-binding site 330214009083 Mg++ binding site; other site 330214009084 metal-binding site 330214009085 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 330214009086 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 330214009087 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214009088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 330214009090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009091 S-adenosylmethionine binding site [chemical binding]; other site 330214009092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 330214009093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 330214009094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214009095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009096 S-adenosylmethionine binding site [chemical binding]; other site 330214009097 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 330214009098 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214009099 Probable Catalytic site; other site 330214009100 metal-binding site 330214009101 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 330214009102 Methyltransferase domain; Region: Methyltransf_11; pfam08241 330214009103 Methyltransferase domain; Region: Methyltransf_11; pfam08241 330214009104 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 330214009105 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 330214009106 Walker A/P-loop; other site 330214009107 ATP binding site [chemical binding]; other site 330214009108 Q-loop/lid; other site 330214009109 ABC transporter signature motif; other site 330214009110 Walker B; other site 330214009111 D-loop; other site 330214009112 H-loop/switch region; other site 330214009113 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 330214009114 putative carbohydrate binding site [chemical binding]; other site 330214009115 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 330214009116 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 330214009117 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 330214009118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 330214009119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 330214009120 Walker A/P-loop; other site 330214009121 ATP binding site [chemical binding]; other site 330214009122 Q-loop/lid; other site 330214009123 ABC transporter signature motif; other site 330214009124 Walker B; other site 330214009125 D-loop; other site 330214009126 H-loop/switch region; other site 330214009127 O-Antigen ligase; Region: Wzy_C; pfam04932 330214009128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009129 TPR motif; other site 330214009130 binding surface 330214009131 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 330214009132 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 330214009133 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 330214009134 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 330214009135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009136 binding surface 330214009137 TPR motif; other site 330214009138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009139 binding surface 330214009140 TPR motif; other site 330214009141 TPR repeat; Region: TPR_11; pfam13414 330214009142 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 330214009143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009144 binding surface 330214009145 TPR motif; other site 330214009146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009147 binding surface 330214009148 TPR motif; other site 330214009149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009150 binding surface 330214009151 TPR motif; other site 330214009152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009153 binding surface 330214009154 TPR motif; other site 330214009155 replicative DNA helicase; Region: DnaB; TIGR00665 330214009156 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 330214009157 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 330214009158 Walker A motif; other site 330214009159 ATP binding site [chemical binding]; other site 330214009160 Walker B motif; other site 330214009161 DNA binding loops [nucleotide binding] 330214009162 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 330214009163 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 330214009164 dimer interface [polypeptide binding]; other site 330214009165 motif 1; other site 330214009166 active site 330214009167 motif 2; other site 330214009168 motif 3; other site 330214009169 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 330214009170 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 330214009171 ligand binding site [chemical binding]; other site 330214009172 NAD binding site [chemical binding]; other site 330214009173 dimerization interface [polypeptide binding]; other site 330214009174 catalytic site [active] 330214009175 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 330214009176 putative L-serine binding site [chemical binding]; other site 330214009177 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 330214009178 homodimer interface [polypeptide binding]; other site 330214009179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214009180 catalytic residue [active] 330214009181 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214009182 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214009183 catalytic residue [active] 330214009184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 330214009185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009186 binding surface 330214009187 TPR motif; other site 330214009188 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 330214009189 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 330214009190 substrate-cofactor binding pocket; other site 330214009191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214009192 catalytic residue [active] 330214009193 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 330214009194 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 330214009195 Walker A motif; other site 330214009196 ATP binding site [chemical binding]; other site 330214009197 Walker B motif; other site 330214009198 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 330214009199 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 330214009200 Walker A motif; other site 330214009201 ATP binding site [chemical binding]; other site 330214009202 Walker B motif; other site 330214009203 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 330214009204 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214009205 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214009206 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 330214009207 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 330214009208 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 330214009209 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 330214009210 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214009211 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214009212 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 330214009213 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 330214009214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 330214009215 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 330214009216 Walker A/P-loop; other site 330214009217 ATP binding site [chemical binding]; other site 330214009218 Q-loop/lid; other site 330214009219 ABC transporter signature motif; other site 330214009220 Walker B; other site 330214009221 D-loop; other site 330214009222 H-loop/switch region; other site 330214009223 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 330214009224 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 330214009225 Response regulator receiver domain; Region: Response_reg; pfam00072 330214009226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009227 active site 330214009228 phosphorylation site [posttranslational modification] 330214009229 intermolecular recognition site; other site 330214009230 dimerization interface [polypeptide binding]; other site 330214009231 PAS fold; Region: PAS_4; pfam08448 330214009232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009233 putative active site [active] 330214009234 heme pocket [chemical binding]; other site 330214009235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009236 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214009237 putative active site [active] 330214009238 heme pocket [chemical binding]; other site 330214009239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009240 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 330214009241 putative active site [active] 330214009242 heme pocket [chemical binding]; other site 330214009243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009244 putative active site [active] 330214009245 heme pocket [chemical binding]; other site 330214009246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214009247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009248 dimer interface [polypeptide binding]; other site 330214009249 phosphorylation site [posttranslational modification] 330214009250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009251 ATP binding site [chemical binding]; other site 330214009252 Mg2+ binding site [ion binding]; other site 330214009253 G-X-G motif; other site 330214009254 glycogen branching enzyme; Provisional; Region: PRK12313 330214009255 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 330214009256 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 330214009257 active site 330214009258 catalytic site [active] 330214009259 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 330214009260 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 330214009261 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 330214009262 PilZ domain; Region: PilZ; cl01260 330214009263 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 330214009264 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 330214009265 Protein export membrane protein; Region: SecD_SecF; cl14618 330214009266 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 330214009267 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214009268 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214009269 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 330214009270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 330214009271 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 330214009272 dimer interface [polypeptide binding]; other site 330214009273 Ubiquitin-like proteins; Region: UBQ; cl00155 330214009274 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 330214009275 Asp-box motif; other site 330214009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 330214009277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 330214009278 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 330214009279 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214009280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 330214009281 active site 330214009282 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 330214009283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214009284 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 330214009285 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 330214009286 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 330214009287 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 330214009288 multidrug efflux protein; Reviewed; Region: PRK09579 330214009289 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214009290 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214009291 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214009292 tellurium resistance terB-like protein; Region: terB_like; cl11965 330214009293 metal binding site [ion binding]; metal-binding site 330214009294 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 330214009295 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 330214009296 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 330214009297 active site residue [active] 330214009298 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214009299 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214009300 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 330214009301 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214009302 GAF domain; Region: GAF; pfam01590 330214009303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214009304 Walker A motif; other site 330214009305 ATP binding site [chemical binding]; other site 330214009306 Walker B motif; other site 330214009307 arginine finger; other site 330214009308 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214009309 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 330214009310 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 330214009311 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 330214009312 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 330214009313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 330214009314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 330214009315 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 330214009316 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 330214009317 Multicopper oxidase; Region: Cu-oxidase; pfam00394 330214009318 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 330214009319 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 330214009320 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 330214009321 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 330214009322 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 330214009323 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 330214009324 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 330214009325 active site 330214009326 catalytic tetrad [active] 330214009327 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 330214009328 putative phosphoketolase; Provisional; Region: PRK05261 330214009329 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 330214009330 TPP-binding site; other site 330214009331 XFP C-terminal domain; Region: XFP_C; pfam09363 330214009332 propionate/acetate kinase; Provisional; Region: PRK12379 330214009333 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 330214009334 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 330214009335 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 330214009336 catalytic residues [active] 330214009337 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 330214009338 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214009339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009340 active site 330214009341 phosphorylation site [posttranslational modification] 330214009342 intermolecular recognition site; other site 330214009343 dimerization interface [polypeptide binding]; other site 330214009344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214009345 Walker A motif; other site 330214009346 ATP binding site [chemical binding]; other site 330214009347 Walker B motif; other site 330214009348 arginine finger; other site 330214009349 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 330214009350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214009351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214009352 dimerization interface [polypeptide binding]; other site 330214009353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009354 dimer interface [polypeptide binding]; other site 330214009355 phosphorylation site [posttranslational modification] 330214009356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009357 ATP binding site [chemical binding]; other site 330214009358 Mg2+ binding site [ion binding]; other site 330214009359 G-X-G motif; other site 330214009360 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 330214009361 Predicted membrane protein [Function unknown]; Region: COG3212 330214009362 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 330214009363 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 330214009364 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 330214009365 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 330214009366 N-terminal plug; other site 330214009367 ligand-binding site [chemical binding]; other site 330214009368 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 330214009369 FecR protein; Region: FecR; pfam04773 330214009370 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 330214009371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214009372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214009373 DNA binding residues [nucleotide binding] 330214009374 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 330214009375 Protein export membrane protein; Region: SecD_SecF; cl14618 330214009376 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 330214009377 Protein export membrane protein; Region: SecD_SecF; cl14618 330214009378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214009379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214009380 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214009381 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 330214009382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 330214009383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 330214009384 dimerization interface [polypeptide binding]; other site 330214009385 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 330214009386 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 330214009387 MOSC domain; Region: MOSC; pfam03473 330214009388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 330214009389 MOSC domain; Region: MOSC; pfam03473 330214009390 3-alpha domain; Region: 3-alpha; pfam03475 330214009391 Response regulator receiver domain; Region: Response_reg; pfam00072 330214009392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009393 active site 330214009394 phosphorylation site [posttranslational modification] 330214009395 intermolecular recognition site; other site 330214009396 dimerization interface [polypeptide binding]; other site 330214009397 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 330214009398 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 330214009399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 330214009400 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 330214009401 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 330214009402 DNA binding site [nucleotide binding] 330214009403 active site 330214009404 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 330214009405 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214009406 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 330214009407 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214009408 active site 330214009409 DNA binding site [nucleotide binding] 330214009410 Int/Topo IB signature motif; other site 330214009411 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 330214009412 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 330214009413 GDP-binding site [chemical binding]; other site 330214009414 ACT binding site; other site 330214009415 IMP binding site; other site 330214009416 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 330214009417 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 330214009418 ABC transporter; Region: ABC_tran_2; pfam12848 330214009419 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 330214009420 PilZ domain; Region: PilZ; pfam07238 330214009421 recombination factor protein RarA; Reviewed; Region: PRK13342 330214009422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214009423 Walker A motif; other site 330214009424 ATP binding site [chemical binding]; other site 330214009425 Walker B motif; other site 330214009426 arginine finger; other site 330214009427 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 330214009428 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 330214009429 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 330214009430 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 330214009431 homodecamer interface [polypeptide binding]; other site 330214009432 GTP cyclohydrolase I; Provisional; Region: PLN03044 330214009433 active site 330214009434 putative catalytic site residues [active] 330214009435 zinc binding site [ion binding]; other site 330214009436 GTP-CH-I/GFRP interaction surface; other site 330214009437 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 330214009438 active site 330214009439 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 330214009440 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 330214009441 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 330214009442 catalytic loop [active] 330214009443 iron binding site [ion binding]; other site 330214009444 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 330214009445 SLBB domain; Region: SLBB; pfam10531 330214009446 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 330214009447 Protein of unknown function (DUF989); Region: DUF989; pfam06181 330214009448 malate dehydrogenase; Reviewed; Region: PRK06223 330214009449 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 330214009450 dimer interface [polypeptide binding]; other site 330214009451 NAD(P) binding site [chemical binding]; other site 330214009452 tetramer (dimer of dimers) interface [polypeptide binding]; other site 330214009453 substrate binding site [chemical binding]; other site 330214009454 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 330214009455 metal ion-dependent adhesion site (MIDAS); other site 330214009456 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; pfam02943 330214009457 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 330214009458 Peptidase family M28; Region: Peptidase_M28; pfam04389 330214009459 metal binding site [ion binding]; metal-binding site 330214009460 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 330214009461 MoxR-like ATPases [General function prediction only]; Region: COG0714 330214009462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214009463 Walker A motif; other site 330214009464 ATP binding site [chemical binding]; other site 330214009465 Walker B motif; other site 330214009466 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 330214009467 PAS domain S-box; Region: sensory_box; TIGR00229 330214009468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009469 putative active site [active] 330214009470 heme pocket [chemical binding]; other site 330214009471 GAF domain; Region: GAF_2; pfam13185 330214009472 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 330214009473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009474 dimer interface [polypeptide binding]; other site 330214009475 phosphorylation site [posttranslational modification] 330214009476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009477 ATP binding site [chemical binding]; other site 330214009478 Mg2+ binding site [ion binding]; other site 330214009479 G-X-G motif; other site 330214009480 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214009481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009482 active site 330214009483 phosphorylation site [posttranslational modification] 330214009484 intermolecular recognition site; other site 330214009485 dimerization interface [polypeptide binding]; other site 330214009486 Flagellin N-methylase; Region: FliB; pfam03692 330214009487 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 330214009488 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 330214009489 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 330214009490 C-terminal domain interface [polypeptide binding]; other site 330214009491 GSH binding site (G-site) [chemical binding]; other site 330214009492 dimer interface [polypeptide binding]; other site 330214009493 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 330214009494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214009495 FeS/SAM binding site; other site 330214009496 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 330214009497 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 330214009498 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 330214009499 trimer interface [polypeptide binding]; other site 330214009500 active site 330214009501 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 330214009502 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 330214009503 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 330214009504 Probable Catalytic site; other site 330214009505 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 330214009506 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 330214009507 classical (c) SDRs; Region: SDR_c; cd05233 330214009508 NAD(P) binding site [chemical binding]; other site 330214009509 active site 330214009510 hypothetical protein; Validated; Region: PRK08238 330214009511 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 330214009512 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 330214009513 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214009514 BolA-like protein; Region: BolA; pfam01722 330214009515 Response regulator receiver domain; Region: Response_reg; pfam00072 330214009516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009517 active site 330214009518 phosphorylation site [posttranslational modification] 330214009519 intermolecular recognition site; other site 330214009520 dimerization interface [polypeptide binding]; other site 330214009521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009522 dimer interface [polypeptide binding]; other site 330214009523 phosphorylation site [posttranslational modification] 330214009524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009525 ATP binding site [chemical binding]; other site 330214009526 Mg2+ binding site [ion binding]; other site 330214009527 G-X-G motif; other site 330214009528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 330214009529 dimerization interface [polypeptide binding]; other site 330214009530 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214009531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009532 dimer interface [polypeptide binding]; other site 330214009533 phosphorylation site [posttranslational modification] 330214009534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009535 ATP binding site [chemical binding]; other site 330214009536 Mg2+ binding site [ion binding]; other site 330214009537 G-X-G motif; other site 330214009538 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214009539 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 330214009540 Domain of unknown function DUF20; Region: UPF0118; pfam01594 330214009541 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 330214009542 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 330214009543 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 330214009544 Transglycosylase; Region: Transgly; pfam00912 330214009545 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 330214009546 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 330214009547 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214009548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214009549 putative active site [active] 330214009550 heme pocket [chemical binding]; other site 330214009551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009552 dimer interface [polypeptide binding]; other site 330214009553 phosphorylation site [posttranslational modification] 330214009554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009555 ATP binding site [chemical binding]; other site 330214009556 Mg2+ binding site [ion binding]; other site 330214009557 G-X-G motif; other site 330214009558 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214009559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009560 active site 330214009561 phosphorylation site [posttranslational modification] 330214009562 intermolecular recognition site; other site 330214009563 dimerization interface [polypeptide binding]; other site 330214009564 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 330214009565 Na binding site [ion binding]; other site 330214009566 putative glycosylation site [posttranslational modification]; other site 330214009567 putative glycosylation site [posttranslational modification]; other site 330214009568 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 330214009569 NmrA-like family; Region: NmrA; pfam05368 330214009570 NADP binding site [chemical binding]; other site 330214009571 active site 330214009572 regulatory binding site [polypeptide binding]; other site 330214009573 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 330214009574 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 330214009575 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 330214009576 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 330214009577 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 330214009578 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 330214009579 putative dimer interface [polypeptide binding]; other site 330214009580 N-terminal domain interface [polypeptide binding]; other site 330214009581 putative substrate binding pocket (H-site) [chemical binding]; other site 330214009582 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 330214009583 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 330214009584 Response regulator receiver domain; Region: Response_reg; pfam00072 330214009585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009586 active site 330214009587 phosphorylation site [posttranslational modification] 330214009588 intermolecular recognition site; other site 330214009589 dimerization interface [polypeptide binding]; other site 330214009590 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 330214009591 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 330214009592 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 330214009593 short chain dehydrogenase; Provisional; Region: PRK06914 330214009594 NADP binding site [chemical binding]; other site 330214009595 active site 330214009596 steroid binding site; other site 330214009597 Protein of unknown function, DUF481; Region: DUF481; pfam04338 330214009598 flavoprotein, HI0933 family; Region: TIGR00275 330214009599 Predicted amidohydrolase [General function prediction only]; Region: COG0388 330214009600 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 330214009601 active site 330214009602 catalytic triad [active] 330214009603 dimer interface [polypeptide binding]; other site 330214009604 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 330214009605 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 330214009606 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 330214009607 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 330214009608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 330214009609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214009610 Coenzyme A binding pocket [chemical binding]; other site 330214009611 OmpW family; Region: OmpW; cl17427 330214009612 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 330214009613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 330214009614 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 330214009615 active site 330214009616 catalytic tetrad [active] 330214009617 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 330214009618 putative NAD(P) binding site [chemical binding]; other site 330214009619 homodimer interface [polypeptide binding]; other site 330214009620 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 330214009621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214009622 Walker A motif; other site 330214009623 ATP binding site [chemical binding]; other site 330214009624 Walker B motif; other site 330214009625 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214009626 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 330214009627 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 330214009628 putative rRNA binding site [nucleotide binding]; other site 330214009629 YaeQ protein; Region: YaeQ; pfam07152 330214009630 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 330214009631 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 330214009632 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 330214009633 active site 330214009634 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 330214009635 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 330214009636 G1 box; other site 330214009637 putative GEF interaction site [polypeptide binding]; other site 330214009638 GTP/Mg2+ binding site [chemical binding]; other site 330214009639 Switch I region; other site 330214009640 G2 box; other site 330214009641 G3 box; other site 330214009642 Switch II region; other site 330214009643 G4 box; other site 330214009644 G5 box; other site 330214009645 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 330214009646 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 330214009647 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 330214009648 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 330214009649 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214009650 ATP binding site [chemical binding]; other site 330214009651 putative Mg++ binding site [ion binding]; other site 330214009652 DEAD-like helicases superfamily; Region: DEXDc; smart00487 330214009653 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 330214009654 ATP binding site [chemical binding]; other site 330214009655 Mg++ binding site [ion binding]; other site 330214009656 motif III; other site 330214009657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214009658 nucleotide binding region [chemical binding]; other site 330214009659 ATP-binding site [chemical binding]; other site 330214009660 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 330214009661 RNA binding site [nucleotide binding]; other site 330214009662 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 330214009663 dimer interface [polypeptide binding]; other site 330214009664 substrate binding site [chemical binding]; other site 330214009665 metal binding sites [ion binding]; metal-binding site 330214009666 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009667 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 330214009668 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 330214009669 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 330214009670 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 330214009671 ligand binding site [chemical binding]; other site 330214009672 flexible hinge region; other site 330214009673 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 330214009674 putative switch regulator; other site 330214009675 non-specific DNA interactions [nucleotide binding]; other site 330214009676 DNA binding site [nucleotide binding] 330214009677 sequence specific DNA binding site [nucleotide binding]; other site 330214009678 putative cAMP binding site [chemical binding]; other site 330214009679 Cytochrome c; Region: Cytochrom_C; pfam00034 330214009680 Cytochrome c; Region: Cytochrom_C; pfam00034 330214009681 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 330214009682 SnoaL-like domain; Region: SnoaL_2; pfam12680 330214009683 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 330214009684 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 330214009685 GIY-YIG motif/motif A; other site 330214009686 putative active site [active] 330214009687 putative metal binding site [ion binding]; other site 330214009688 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 330214009689 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 330214009690 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214009692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214009693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214009694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 330214009695 putative substrate translocation pore; other site 330214009696 Membrane transport protein; Region: Mem_trans; cl09117 330214009697 Methyltransferase domain; Region: Methyltransf_26; pfam13659 330214009698 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 330214009699 Restriction endonuclease XhoI; Region: XhoI; pfam04555 330214009700 TPR repeat; Region: TPR_11; pfam13414 330214009701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009702 binding surface 330214009703 TPR motif; other site 330214009704 TPR repeat; Region: TPR_11; pfam13414 330214009705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009706 binding surface 330214009707 TPR repeat; Region: TPR_11; pfam13414 330214009708 TPR motif; other site 330214009709 TPR repeat; Region: TPR_11; pfam13414 330214009710 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 330214009711 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 330214009712 active site 330214009713 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 330214009714 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 330214009715 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 330214009716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009717 S-adenosylmethionine binding site [chemical binding]; other site 330214009718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 330214009719 TfoX N-terminal domain; Region: TfoX_N; pfam04993 330214009720 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 330214009721 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 330214009722 RNA polymerase sigma factor; Provisional; Region: PRK12519 330214009723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214009724 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214009725 DNA binding residues [nucleotide binding] 330214009726 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 330214009727 apolar tunnel; other site 330214009728 heme binding site [chemical binding]; other site 330214009729 dimerization interface [polypeptide binding]; other site 330214009730 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 330214009731 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 330214009732 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 330214009733 Patatin-like phospholipase; Region: Patatin; pfam01734 330214009734 nucleophile elbow; other site 330214009735 MAEBL; Provisional; Region: PTZ00121 330214009736 YEATS family; Region: YEATS; pfam03366 330214009737 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 330214009738 Predicted transcriptional regulators [Transcription]; Region: COG1733 330214009739 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214009740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009741 S-adenosylmethionine binding site [chemical binding]; other site 330214009742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 330214009743 dimerization interface [polypeptide binding]; other site 330214009744 putative DNA binding site [nucleotide binding]; other site 330214009745 putative Zn2+ binding site [ion binding]; other site 330214009746 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 330214009747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214009748 FeS/SAM binding site; other site 330214009749 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 330214009750 Phosphate transporter family; Region: PHO4; pfam01384 330214009751 Phosphate transporter family; Region: PHO4; pfam01384 330214009752 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 330214009753 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 330214009754 iron-sulfur cluster [ion binding]; other site 330214009755 [2Fe-2S] cluster binding site [ion binding]; other site 330214009756 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 330214009757 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 330214009758 molybdopterin cofactor binding site; other site 330214009759 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 330214009760 molybdopterin cofactor binding site; other site 330214009761 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 330214009762 Low molecular weight phosphatase family; Region: LMWPc; cd00115 330214009763 active site 330214009764 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 330214009765 Sodium Bile acid symporter family; Region: SBF; cl17470 330214009766 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214009767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009768 S-adenosylmethionine binding site [chemical binding]; other site 330214009769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 330214009770 dimerization interface [polypeptide binding]; other site 330214009771 putative DNA binding site [nucleotide binding]; other site 330214009772 putative Zn2+ binding site [ion binding]; other site 330214009773 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 330214009774 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 330214009775 HflK protein; Region: hflK; TIGR01933 330214009776 HflC protein; Region: hflC; TIGR01932 330214009777 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 330214009778 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 330214009779 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 330214009780 Potassium binding sites [ion binding]; other site 330214009781 Cesium cation binding sites [ion binding]; other site 330214009782 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 330214009783 Peptidase family M23; Region: Peptidase_M23; pfam01551 330214009784 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 330214009785 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 330214009786 active site residue [active] 330214009787 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214009788 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 330214009789 NAD binding site [chemical binding]; other site 330214009790 substrate binding site [chemical binding]; other site 330214009791 homodimer interface [polypeptide binding]; other site 330214009792 active site 330214009793 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 330214009794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214009795 RNA binding surface [nucleotide binding]; other site 330214009796 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 330214009797 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 330214009798 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 330214009799 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 330214009800 generic binding surface II; other site 330214009801 generic binding surface I; other site 330214009802 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 330214009803 putative active site [active] 330214009804 metal binding site [ion binding]; metal-binding site 330214009805 homodimer binding site [polypeptide binding]; other site 330214009806 phosphodiesterase; Provisional; Region: PRK12704 330214009807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214009808 Zn2+ binding site [ion binding]; other site 330214009809 Mg2+ binding site [ion binding]; other site 330214009810 Cell division protein ZapA; Region: ZapA; pfam05164 330214009811 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 330214009812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214009813 binding surface 330214009814 TPR motif; other site 330214009815 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 330214009816 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214009817 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214009818 catalytic residue [active] 330214009819 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 330214009820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214009821 FeS/SAM binding site; other site 330214009822 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 330214009823 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 330214009824 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 330214009825 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 330214009826 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 330214009827 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 330214009828 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 330214009829 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 330214009830 Ligand Binding Site [chemical binding]; other site 330214009831 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 330214009832 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 330214009833 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 330214009834 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 330214009835 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 330214009836 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 330214009837 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 330214009838 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 330214009839 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 330214009840 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 330214009841 homodimer interface [polypeptide binding]; other site 330214009842 substrate-cofactor binding pocket; other site 330214009843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214009844 catalytic residue [active] 330214009845 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 330214009846 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214009847 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214009848 catalytic residue [active] 330214009849 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 330214009850 L-aspartate oxidase; Provisional; Region: PRK06175 330214009851 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 330214009852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 330214009853 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 330214009854 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 330214009855 Walker A/P-loop; other site 330214009856 ATP binding site [chemical binding]; other site 330214009857 Q-loop/lid; other site 330214009858 ABC transporter signature motif; other site 330214009859 Walker B; other site 330214009860 D-loop; other site 330214009861 H-loop/switch region; other site 330214009862 Phosphoesterase family; Region: Phosphoesterase; pfam04185 330214009863 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 330214009864 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 330214009865 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 330214009866 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 330214009867 Soluble P-type ATPase [General function prediction only]; Region: COG4087 330214009868 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 330214009869 TPR repeat; Region: TPR_11; pfam13414 330214009870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214009871 TPR motif; other site 330214009872 TPR repeat; Region: TPR_11; pfam13414 330214009873 binding surface 330214009874 PilZ domain; Region: PilZ; pfam07238 330214009875 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 330214009876 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 330214009877 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 330214009878 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 330214009879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214009880 dimer interface [polypeptide binding]; other site 330214009881 phosphorylation site [posttranslational modification] 330214009882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214009883 ATP binding site [chemical binding]; other site 330214009884 Mg2+ binding site [ion binding]; other site 330214009885 G-X-G motif; other site 330214009886 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214009887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214009888 active site 330214009889 phosphorylation site [posttranslational modification] 330214009890 intermolecular recognition site; other site 330214009891 dimerization interface [polypeptide binding]; other site 330214009892 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 330214009893 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 330214009894 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 330214009895 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 330214009896 Soluble P-type ATPase [General function prediction only]; Region: COG4087 330214009897 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 330214009898 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 330214009899 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214009900 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214009901 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214009902 Ligand Binding Site [chemical binding]; other site 330214009903 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214009904 Ligand Binding Site [chemical binding]; other site 330214009905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 330214009906 Uncharacterized conserved protein [Function unknown]; Region: COG4933 330214009907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 330214009908 Coenzyme A binding pocket [chemical binding]; other site 330214009909 PIN domain; Region: PIN_3; pfam13470 330214009910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 330214009911 HTH-like domain; Region: HTH_21; pfam13276 330214009912 Integrase core domain; Region: rve; pfam00665 330214009913 Integrase core domain; Region: rve_3; pfam13683 330214009914 Transposase; Region: HTH_Tnp_1; pfam01527 330214009915 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214009916 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214009917 catalytic residue [active] 330214009918 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 330214009919 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 330214009920 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 330214009921 catalytic site [active] 330214009922 active site 330214009923 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 330214009924 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 330214009925 ligand-binding site [chemical binding]; other site 330214009926 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 330214009927 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 330214009928 30S subunit binding site; other site 330214009929 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 330214009930 DNA-binding site [nucleotide binding]; DNA binding site 330214009931 RNA-binding motif; other site 330214009932 AAA domain; Region: AAA_32; pfam13654 330214009933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 330214009934 Walker A motif; other site 330214009935 ATP binding site [chemical binding]; other site 330214009936 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 330214009937 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 330214009938 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 330214009939 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214009940 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214009941 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 330214009942 Isochorismatase family; Region: Isochorismatase; pfam00857 330214009943 catalytic triad [active] 330214009944 metal binding site [ion binding]; metal-binding site 330214009945 conserved cis-peptide bond; other site 330214009946 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 330214009947 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 330214009948 active site 330214009949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009950 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 330214009951 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009952 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009953 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009954 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 330214009955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009956 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009957 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 330214009959 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 330214009960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 330214009961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 330214009962 putative substrate translocation pore; other site 330214009963 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009964 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214009965 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009966 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 330214009967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214009968 Ligand Binding Site [chemical binding]; other site 330214009969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214009970 Ligand Binding Site [chemical binding]; other site 330214009971 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 330214009972 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 330214009973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 330214009974 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 330214009975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214009976 motif II; other site 330214009977 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 330214009978 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214009980 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009981 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009982 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214009983 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 330214009984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009985 S-adenosylmethionine binding site [chemical binding]; other site 330214009986 Short C-terminal domain; Region: SHOCT; pfam09851 330214009987 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 330214009988 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214009989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214009990 S-adenosylmethionine binding site [chemical binding]; other site 330214009991 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 330214009992 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 330214009993 FOG: CBS domain [General function prediction only]; Region: COG0517 330214009994 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 330214009995 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 330214009996 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 330214009997 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 330214009998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214009999 Walker A/P-loop; other site 330214010000 ATP binding site [chemical binding]; other site 330214010001 Q-loop/lid; other site 330214010002 ABC transporter signature motif; other site 330214010003 Walker B; other site 330214010004 D-loop; other site 330214010005 H-loop/switch region; other site 330214010006 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 330214010007 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 330214010008 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 330214010009 putative active site [active] 330214010010 putative catalytic site [active] 330214010011 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 330214010012 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 330214010013 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 330214010014 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 330214010015 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 330214010016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214010017 TPR motif; other site 330214010018 binding surface 330214010019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214010020 TPR motif; other site 330214010021 TPR repeat; Region: TPR_11; pfam13414 330214010022 binding surface 330214010023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214010024 binding surface 330214010025 TPR motif; other site 330214010026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214010027 binding surface 330214010028 TPR motif; other site 330214010029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214010030 binding surface 330214010031 TPR motif; other site 330214010032 TPR repeat; Region: TPR_11; pfam13414 330214010033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214010034 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 330214010035 TPR motif; other site 330214010036 binding surface 330214010037 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010038 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 330214010039 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 330214010040 putative active site [active] 330214010041 putative metal binding site [ion binding]; other site 330214010042 Bacterial PH domain; Region: DUF304; pfam03703 330214010043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214010044 active site 330214010045 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 330214010046 substrate binding site [chemical binding]; other site 330214010047 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 330214010048 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 330214010049 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 330214010050 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 330214010051 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 330214010052 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 330214010053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 330214010054 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 330214010055 PAS domain S-box; Region: sensory_box; TIGR00229 330214010056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214010057 putative active site [active] 330214010058 heme pocket [chemical binding]; other site 330214010059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214010060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214010061 DNA binding residues [nucleotide binding] 330214010062 dimerization interface [polypeptide binding]; other site 330214010063 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 330214010064 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214010065 Ligand Binding Site [chemical binding]; other site 330214010066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214010067 Ligand Binding Site [chemical binding]; other site 330214010068 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 330214010069 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 330214010070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214010071 non-specific DNA binding site [nucleotide binding]; other site 330214010072 salt bridge; other site 330214010073 sequence-specific DNA binding site [nucleotide binding]; other site 330214010074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 330214010075 active site 330214010076 metal binding site [ion binding]; metal-binding site 330214010077 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 330214010078 Malic enzyme, N-terminal domain; Region: malic; pfam00390 330214010079 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 330214010080 putative NAD(P) binding site [chemical binding]; other site 330214010081 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 330214010082 hypothetical protein; Provisional; Region: PRK08609 330214010083 active site 330214010084 primer binding site [nucleotide binding]; other site 330214010085 NTP binding site [chemical binding]; other site 330214010086 metal binding triad [ion binding]; metal-binding site 330214010087 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 330214010088 active site 330214010089 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 330214010090 Predicted GTPase [General function prediction only]; Region: COG2403 330214010091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 330214010092 acetyl-CoA synthetase; Provisional; Region: PRK04319 330214010093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 330214010094 acyl-activating enzyme (AAE) consensus motif; other site 330214010095 AMP binding site [chemical binding]; other site 330214010096 active site 330214010097 CoA binding site [chemical binding]; other site 330214010098 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 330214010099 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 330214010100 tetramer interface [polypeptide binding]; other site 330214010101 TPP-binding site [chemical binding]; other site 330214010102 heterodimer interface [polypeptide binding]; other site 330214010103 phosphorylation loop region [posttranslational modification] 330214010104 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 330214010105 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 330214010106 alpha subunit interface [polypeptide binding]; other site 330214010107 TPP binding site [chemical binding]; other site 330214010108 heterodimer interface [polypeptide binding]; other site 330214010109 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214010110 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 330214010111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 330214010112 E3 interaction surface; other site 330214010113 lipoyl attachment site [posttranslational modification]; other site 330214010114 e3 binding domain; Region: E3_binding; pfam02817 330214010115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 330214010116 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 330214010117 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 330214010118 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 330214010119 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 330214010120 putative dimer interface [polypeptide binding]; other site 330214010121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 330214010122 active site 330214010123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214010124 Ligand Binding Site [chemical binding]; other site 330214010125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214010126 Ligand Binding Site [chemical binding]; other site 330214010127 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214010128 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214010129 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 330214010130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 330214010131 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 330214010132 CoA binding domain; Region: CoA_binding_2; pfam13380 330214010133 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 330214010134 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 330214010135 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 330214010136 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 330214010137 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 330214010138 Cytochrome C' Region: Cytochrom_C_2; cl01610 330214010139 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 330214010140 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 330214010141 TPP-binding site [chemical binding]; other site 330214010142 putative dimer interface [polypeptide binding]; other site 330214010143 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 330214010144 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 330214010145 dimer interface [polypeptide binding]; other site 330214010146 PYR/PP interface [polypeptide binding]; other site 330214010147 TPP binding site [chemical binding]; other site 330214010148 substrate binding site [chemical binding]; other site 330214010149 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 330214010150 active site 330214010151 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 330214010152 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 330214010153 4Fe-4S binding domain; Region: Fer4; cl02805 330214010154 4Fe-4S binding domain; Region: Fer4; pfam00037 330214010155 YtxH-like protein; Region: YtxH; pfam12732 330214010156 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 330214010157 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 330214010158 catalytic residues [active] 330214010159 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214010160 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 330214010161 DsrE/DsrF-like family; Region: DrsE; pfam02635 330214010162 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010163 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214010164 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010165 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010166 Cytochrome c; Region: Cytochrom_C; cl11414 330214010167 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214010168 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 330214010169 sulfite oxidase; Provisional; Region: PLN00177 330214010170 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 330214010171 Moco binding site; other site 330214010172 metal coordination site [ion binding]; other site 330214010173 dimerization interface [polypeptide binding]; other site 330214010174 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 330214010175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214010176 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010177 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 330214010178 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010179 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 330214010180 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 330214010181 Qi binding site; other site 330214010182 intrachain domain interface; other site 330214010183 interchain domain interface [polypeptide binding]; other site 330214010184 heme bH binding site [chemical binding]; other site 330214010185 heme bL binding site [chemical binding]; other site 330214010186 Qo binding site; other site 330214010187 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 330214010188 Qo binding site; other site 330214010189 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010190 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 330214010191 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 330214010192 iron-sulfur cluster [ion binding]; other site 330214010193 [2Fe-2S] cluster binding site [ion binding]; other site 330214010194 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 330214010195 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214010196 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010197 OsmC-like protein; Region: OsmC; cl00767 330214010198 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 330214010199 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 330214010200 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214010201 Ligand Binding Site [chemical binding]; other site 330214010202 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 330214010203 Ligand Binding Site [chemical binding]; other site 330214010204 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 330214010205 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 330214010206 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 330214010207 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 330214010208 VIT family; Region: VIT1; pfam01988 330214010209 VIT family; Region: VIT1; pfam01988 330214010210 Protein of unknown function (DUF330); Region: DUF330; cl01135 330214010211 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 330214010212 mce related protein; Region: MCE; pfam02470 330214010213 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 330214010214 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 330214010215 Walker A/P-loop; other site 330214010216 ATP binding site [chemical binding]; other site 330214010217 Q-loop/lid; other site 330214010218 ABC transporter signature motif; other site 330214010219 Walker B; other site 330214010220 D-loop; other site 330214010221 H-loop/switch region; other site 330214010222 STAS domain; Region: STAS_2; pfam13466 330214010223 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 330214010224 Permease; Region: Permease; pfam02405 330214010225 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 330214010226 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 330214010227 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 330214010228 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 330214010229 Cupin domain; Region: Cupin_2; pfam07883 330214010230 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 330214010231 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 330214010232 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 330214010233 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214010234 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214010235 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 330214010236 Predicted permeases [General function prediction only]; Region: COG0730 330214010237 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 330214010238 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 330214010239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 330214010240 CHASE3 domain; Region: CHASE3; pfam05227 330214010241 Predicted integral membrane protein [Function unknown]; Region: COG5615 330214010242 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 330214010243 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 330214010244 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 330214010245 ligand binding site [chemical binding]; other site 330214010246 flexible hinge region; other site 330214010247 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 330214010248 non-specific DNA interactions [nucleotide binding]; other site 330214010249 DNA binding site [nucleotide binding] 330214010250 sequence specific DNA binding site [nucleotide binding]; other site 330214010251 putative cAMP binding site [chemical binding]; other site 330214010252 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214010253 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214010254 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214010255 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214010256 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 330214010257 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 330214010258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214010259 Walker A motif; other site 330214010260 ATP binding site [chemical binding]; other site 330214010261 Walker B motif; other site 330214010262 arginine finger; other site 330214010263 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214010264 Response regulator receiver domain; Region: Response_reg; pfam00072 330214010265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010266 active site 330214010267 phosphorylation site [posttranslational modification] 330214010268 intermolecular recognition site; other site 330214010269 dimerization interface [polypeptide binding]; other site 330214010270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214010271 PAS domain; Region: PAS_9; pfam13426 330214010272 putative active site [active] 330214010273 heme pocket [chemical binding]; other site 330214010274 PAS fold; Region: PAS_4; pfam08448 330214010275 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 330214010276 PAS domain S-box; Region: sensory_box; TIGR00229 330214010277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214010278 putative active site [active] 330214010279 heme pocket [chemical binding]; other site 330214010280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214010281 PAS fold; Region: PAS_3; pfam08447 330214010282 putative active site [active] 330214010283 heme pocket [chemical binding]; other site 330214010284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214010285 dimer interface [polypeptide binding]; other site 330214010286 phosphorylation site [posttranslational modification] 330214010287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214010288 ATP binding site [chemical binding]; other site 330214010289 Mg2+ binding site [ion binding]; other site 330214010290 G-X-G motif; other site 330214010291 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214010292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010293 active site 330214010294 phosphorylation site [posttranslational modification] 330214010295 intermolecular recognition site; other site 330214010296 dimerization interface [polypeptide binding]; other site 330214010297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214010298 Walker A motif; other site 330214010299 ATP binding site [chemical binding]; other site 330214010300 Walker B motif; other site 330214010301 arginine finger; other site 330214010302 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214010303 macrolide transporter subunit MacA; Provisional; Region: PRK11578 330214010304 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214010305 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 330214010306 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 330214010307 FtsX-like permease family; Region: FtsX; pfam02687 330214010308 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 330214010309 Mechanosensitive ion channel; Region: MS_channel; pfam00924 330214010310 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 330214010311 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 330214010312 lipoyl synthase; Provisional; Region: PRK05481 330214010313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 330214010314 FeS/SAM binding site; other site 330214010315 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 330214010316 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 330214010317 E3 interaction surface; other site 330214010318 lipoyl attachment site [posttranslational modification]; other site 330214010319 e3 binding domain; Region: E3_binding; pfam02817 330214010320 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 330214010321 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 330214010322 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 330214010323 alpha subunit interface [polypeptide binding]; other site 330214010324 TPP binding site [chemical binding]; other site 330214010325 heterodimer interface [polypeptide binding]; other site 330214010326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 330214010327 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 330214010328 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 330214010329 tetramer interface [polypeptide binding]; other site 330214010330 TPP-binding site [chemical binding]; other site 330214010331 heterodimer interface [polypeptide binding]; other site 330214010332 phosphorylation loop region [posttranslational modification] 330214010333 Maf-like protein; Region: Maf; pfam02545 330214010334 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 330214010335 active site 330214010336 dimer interface [polypeptide binding]; other site 330214010337 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 330214010338 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 330214010339 FMN binding site [chemical binding]; other site 330214010340 active site 330214010341 catalytic residues [active] 330214010342 substrate binding site [chemical binding]; other site 330214010343 Protein of unknown function (DUF692); Region: DUF692; cl01263 330214010344 FOG: CBS domain [General function prediction only]; Region: COG0517 330214010345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 330214010346 PilZ domain; Region: PilZ; pfam07238 330214010347 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 330214010348 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 330214010349 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 330214010350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214010351 ATP binding site [chemical binding]; other site 330214010352 Mg2+ binding site [ion binding]; other site 330214010353 G-X-G motif; other site 330214010354 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 330214010355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010356 active site 330214010357 phosphorylation site [posttranslational modification] 330214010358 intermolecular recognition site; other site 330214010359 dimerization interface [polypeptide binding]; other site 330214010360 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 330214010361 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 330214010362 NAD binding site [chemical binding]; other site 330214010363 ATP-grasp domain; Region: ATP-grasp; pfam02222 330214010364 AIR carboxylase; Region: AIRC; pfam00731 330214010365 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 330214010366 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 330214010367 HlyD family secretion protein; Region: HlyD_3; pfam13437 330214010368 Outer membrane efflux protein; Region: OEP; pfam02321 330214010369 Outer membrane efflux protein; Region: OEP; pfam02321 330214010370 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 330214010371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214010372 Walker A/P-loop; other site 330214010373 ATP binding site [chemical binding]; other site 330214010374 Q-loop/lid; other site 330214010375 ABC transporter signature motif; other site 330214010376 Walker B; other site 330214010377 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 330214010378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214010379 Walker A/P-loop; other site 330214010380 ATP binding site [chemical binding]; other site 330214010381 Q-loop/lid; other site 330214010382 ABC transporter signature motif; other site 330214010383 Walker B; other site 330214010384 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 330214010385 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 330214010386 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 330214010387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 330214010388 RNA binding surface [nucleotide binding]; other site 330214010389 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 330214010390 active site 330214010391 agmatinase; Region: agmatinase; TIGR01230 330214010392 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 330214010393 putative active site [active] 330214010394 Mn binding site [ion binding]; other site 330214010395 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 330214010396 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 330214010397 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 330214010398 NAD(P) binding site [chemical binding]; other site 330214010399 catalytic residues [active] 330214010400 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 330214010401 Thioredoxin; Region: Thioredoxin_4; pfam13462 330214010402 Deoxyhypusine synthase; Region: DS; cl00826 330214010403 deoxyhypusine synthase; Region: dhys; TIGR00321 330214010404 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 330214010405 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214010406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214010407 S-adenosylmethionine binding site [chemical binding]; other site 330214010408 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214010409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010410 active site 330214010411 phosphorylation site [posttranslational modification] 330214010412 intermolecular recognition site; other site 330214010413 dimerization interface [polypeptide binding]; other site 330214010414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214010415 DNA binding residues [nucleotide binding] 330214010416 dimerization interface [polypeptide binding]; other site 330214010417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 330214010418 Histidine kinase; Region: HisKA_3; pfam07730 330214010419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214010420 ATP binding site [chemical binding]; other site 330214010421 Mg2+ binding site [ion binding]; other site 330214010422 G-X-G motif; other site 330214010423 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 330214010424 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 330214010425 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 330214010426 DNA binding residues [nucleotide binding] 330214010427 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214010428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214010429 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 330214010430 active site 330214010431 Int/Topo IB signature motif; other site 330214010432 DNA binding site [nucleotide binding] 330214010433 CGNR zinc finger; Region: zf-CGNR; pfam11706 330214010434 Phage head maturation protease [General function prediction only]; Region: COG3740 330214010435 Phage terminase, small subunit; Region: Terminase_4; pfam05119 330214010436 Phage terminase, small subunit; Region: Terminase_4; cl01525 330214010437 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214010438 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 330214010439 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 330214010440 active site 330214010441 DNA binding site [nucleotide binding] 330214010442 Int/Topo IB signature motif; other site 330214010443 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 330214010444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 330214010445 active site 330214010446 HIGH motif; other site 330214010447 nucleotide binding site [chemical binding]; other site 330214010448 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 330214010449 KMSKS motif; other site 330214010450 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 330214010451 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 330214010452 Zinc-binding sites [ion binding]; other site 330214010453 zinc cluster 1 [ion binding]; other site 330214010454 putative charged binding surface; other site 330214010455 putative hydrophobic binding surface; other site 330214010456 zinc cluster 2 [ion binding]; other site 330214010457 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 330214010458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 330214010459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 330214010460 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 330214010461 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 330214010462 HIGH motif; other site 330214010463 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 330214010464 active site 330214010465 KMSKS motif; other site 330214010466 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 330214010467 FAD binding pocket [chemical binding]; other site 330214010468 conserved FAD binding motif [chemical binding]; other site 330214010469 phosphate binding motif [ion binding]; other site 330214010470 beta-alpha-beta structure motif; other site 330214010471 NAD binding pocket [chemical binding]; other site 330214010472 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 330214010473 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 330214010474 catalytic loop [active] 330214010475 iron binding site [ion binding]; other site 330214010476 Predicted transcriptional regulator [Transcription]; Region: COG1959 330214010477 Transcriptional regulator; Region: Rrf2; pfam02082 330214010478 cysteine desulfurase; Provisional; Region: PRK14012 330214010479 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 330214010480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 330214010481 catalytic residue [active] 330214010482 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 330214010483 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 330214010484 trimerization site [polypeptide binding]; other site 330214010485 active site 330214010486 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 330214010487 co-chaperone HscB; Provisional; Region: hscB; PRK05014 330214010488 DnaJ domain; Region: DnaJ; pfam00226 330214010489 HSP70 interaction site [polypeptide binding]; other site 330214010490 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 330214010491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 330214010492 nucleotide binding site [chemical binding]; other site 330214010493 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 330214010494 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 330214010495 Transglycosylase; Region: Transgly; pfam00912 330214010496 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 330214010497 RNA binding site [nucleotide binding]; other site 330214010498 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 330214010499 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 330214010500 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 330214010501 G1 box; other site 330214010502 putative GEF interaction site [polypeptide binding]; other site 330214010503 GTP/Mg2+ binding site [chemical binding]; other site 330214010504 Switch I region; other site 330214010505 G2 box; other site 330214010506 G3 box; other site 330214010507 Switch II region; other site 330214010508 G4 box; other site 330214010509 G5 box; other site 330214010510 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 330214010511 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 330214010512 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 330214010513 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 330214010514 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 330214010515 dimer interface [polypeptide binding]; other site 330214010516 catalytic triad [active] 330214010517 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 330214010518 catalytic residues [active] 330214010519 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214010520 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214010521 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 330214010522 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 330214010523 ligand binding site [chemical binding]; other site 330214010524 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 330214010525 active site 330214010526 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 330214010527 active site 330214010528 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 330214010529 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 330214010530 Cysteine-rich domain; Region: CCG; pfam02754 330214010531 Cysteine-rich domain; Region: CCG; pfam02754 330214010532 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 330214010533 Ferritin-like domain; Region: Ferritin; pfam00210 330214010534 binuclear metal center [ion binding]; other site 330214010535 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 330214010536 metal binding site 2 [ion binding]; metal-binding site 330214010537 putative DNA binding helix; other site 330214010538 metal binding site 1 [ion binding]; metal-binding site 330214010539 dimer interface [polypeptide binding]; other site 330214010540 structural Zn2+ binding site [ion binding]; other site 330214010541 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 330214010542 Melibiase; Region: Melibiase; pfam02065 330214010543 Ubiquitin-like proteins; Region: UBQ; cl00155 330214010544 charged pocket; other site 330214010545 hydrophobic patch; other site 330214010546 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 330214010547 IHF dimer interface [polypeptide binding]; other site 330214010548 IHF - DNA interface [nucleotide binding]; other site 330214010549 PilZ domain; Region: PilZ; cl01260 330214010550 Cytochrome c; Region: Cytochrom_C; pfam00034 330214010551 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 330214010552 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 330214010553 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 330214010554 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214010555 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 330214010556 active site 330214010557 aldehyde dehydrogenase family 7 member; Region: PLN02315 330214010558 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 330214010559 tetrameric interface [polypeptide binding]; other site 330214010560 NAD binding site [chemical binding]; other site 330214010561 catalytic residues [active] 330214010562 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 330214010563 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 330214010564 NAD(P) binding pocket [chemical binding]; other site 330214010565 PSP1 C-terminal conserved region; Region: PSP1; cl00770 330214010566 Domain of unknown function (DUF955); Region: DUF955; pfam06114 330214010567 Uncharacterized conserved protein [Function unknown]; Region: COG2947 330214010568 Uncharacterized conserved protein [Function unknown]; Region: COG1434 330214010569 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 330214010570 putative active site [active] 330214010571 Flagellin N-methylase; Region: FliB; pfam03692 330214010572 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 330214010573 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 330214010574 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 330214010575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214010576 ATP binding site [chemical binding]; other site 330214010577 putative Mg++ binding site [ion binding]; other site 330214010578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214010579 nucleotide binding region [chemical binding]; other site 330214010580 ATP-binding site [chemical binding]; other site 330214010581 RQC domain; Region: RQC; pfam09382 330214010582 HRDC domain; Region: HRDC; pfam00570 330214010583 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 330214010584 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 330214010585 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 330214010586 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214010587 Methyltransferase domain; Region: Methyltransf_26; pfam13659 330214010588 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 330214010589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 330214010590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214010591 Walker A/P-loop; other site 330214010592 ATP binding site [chemical binding]; other site 330214010593 Q-loop/lid; other site 330214010594 ABC transporter signature motif; other site 330214010595 Walker B; other site 330214010596 D-loop; other site 330214010597 H-loop/switch region; other site 330214010598 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 330214010599 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 330214010600 Ligand binding site; other site 330214010601 Putative Catalytic site; other site 330214010602 DXD motif; other site 330214010603 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 330214010604 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 330214010605 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 330214010606 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 330214010607 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 330214010608 active site 330214010609 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214010610 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214010611 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 330214010612 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 330214010613 Zn binding site [ion binding]; other site 330214010614 Response regulator receiver domain; Region: Response_reg; pfam00072 330214010615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010616 active site 330214010617 phosphorylation site [posttranslational modification] 330214010618 intermolecular recognition site; other site 330214010619 dimerization interface [polypeptide binding]; other site 330214010620 Response regulator receiver domain; Region: Response_reg; pfam00072 330214010621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010622 active site 330214010623 phosphorylation site [posttranslational modification] 330214010624 intermolecular recognition site; other site 330214010625 dimerization interface [polypeptide binding]; other site 330214010626 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 330214010627 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 330214010628 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 330214010629 P loop; other site 330214010630 GTP binding site [chemical binding]; other site 330214010631 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 330214010632 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 330214010633 PhoH-like protein; Region: PhoH; pfam02562 330214010634 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 330214010635 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 330214010636 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 330214010637 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 330214010638 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 330214010639 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 330214010640 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 330214010641 Walker A motif; other site 330214010642 ATP binding site [chemical binding]; other site 330214010643 Walker B motif; other site 330214010644 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 330214010645 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 330214010646 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 330214010647 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 330214010648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 330214010649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 330214010650 DNA binding residues [nucleotide binding] 330214010651 dimerization interface [polypeptide binding]; other site 330214010652 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 330214010653 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 330214010654 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 330214010655 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 330214010656 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 330214010657 active site 330214010658 HIGH motif; other site 330214010659 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 330214010660 KMSKS motif; other site 330214010661 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 330214010662 tRNA binding surface [nucleotide binding]; other site 330214010663 anticodon binding site; other site 330214010664 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 330214010665 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 330214010666 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 330214010667 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 330214010668 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 330214010669 DNA binding residues [nucleotide binding] 330214010670 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 330214010671 IHF - DNA interface [nucleotide binding]; other site 330214010672 IHF dimer interface [polypeptide binding]; other site 330214010673 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 330214010674 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 330214010675 active site 330214010676 catalytic residues [active] 330214010677 metal binding site [ion binding]; metal-binding site 330214010678 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 330214010679 aspartate kinase; Reviewed; Region: PRK06635 330214010680 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 330214010681 putative nucleotide binding site [chemical binding]; other site 330214010682 putative catalytic residues [active] 330214010683 putative Mg ion binding site [ion binding]; other site 330214010684 putative aspartate binding site [chemical binding]; other site 330214010685 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 330214010686 putative allosteric regulatory site; other site 330214010687 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 330214010688 putative allosteric regulatory residue; other site 330214010689 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 330214010690 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 330214010691 threonine synthase; Reviewed; Region: PRK06721 330214010692 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 330214010693 homodimer interface [polypeptide binding]; other site 330214010694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214010695 catalytic residue [active] 330214010696 homoserine dehydrogenase; Provisional; Region: PRK06349 330214010697 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 330214010698 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 330214010699 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 330214010700 aminotransferase; Validated; Region: PRK08175 330214010701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214010702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214010703 homodimer interface [polypeptide binding]; other site 330214010704 catalytic residue [active] 330214010705 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 330214010706 active site 330214010707 hydrophilic channel; other site 330214010708 dimerization interface [polypeptide binding]; other site 330214010709 catalytic residues [active] 330214010710 active site lid [active] 330214010711 Uncharacterized conserved protein [Function unknown]; Region: COG0062 330214010712 putative carbohydrate kinase; Provisional; Region: PRK10565 330214010713 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 330214010714 putative substrate binding site [chemical binding]; other site 330214010715 putative ATP binding site [chemical binding]; other site 330214010716 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 330214010717 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 330214010718 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 330214010719 MutS domain I; Region: MutS_I; pfam01624 330214010720 MutS domain II; Region: MutS_II; pfam05188 330214010721 MutS domain III; Region: MutS_III; pfam05192 330214010722 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 330214010723 Walker A/P-loop; other site 330214010724 ATP binding site [chemical binding]; other site 330214010725 Q-loop/lid; other site 330214010726 ABC transporter signature motif; other site 330214010727 Walker B; other site 330214010728 D-loop; other site 330214010729 H-loop/switch region; other site 330214010730 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 330214010731 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 330214010732 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 330214010733 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 330214010734 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 330214010735 RNase E interface [polypeptide binding]; other site 330214010736 trimer interface [polypeptide binding]; other site 330214010737 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 330214010738 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 330214010739 RNase E interface [polypeptide binding]; other site 330214010740 trimer interface [polypeptide binding]; other site 330214010741 active site 330214010742 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 330214010743 putative nucleic acid binding region [nucleotide binding]; other site 330214010744 G-X-X-G motif; other site 330214010745 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 330214010746 RNA binding site [nucleotide binding]; other site 330214010747 domain interface; other site 330214010748 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 330214010749 16S/18S rRNA binding site [nucleotide binding]; other site 330214010750 S13e-L30e interaction site [polypeptide binding]; other site 330214010751 25S rRNA binding site [nucleotide binding]; other site 330214010752 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 330214010753 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 330214010754 RNA binding site [nucleotide binding]; other site 330214010755 active site 330214010756 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 330214010757 Protein of unknown function (DUF503); Region: DUF503; pfam04456 330214010758 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 330214010759 translation initiation factor IF-2; Region: IF-2; TIGR00487 330214010760 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 330214010761 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 330214010762 G1 box; other site 330214010763 putative GEF interaction site [polypeptide binding]; other site 330214010764 GTP/Mg2+ binding site [chemical binding]; other site 330214010765 Switch I region; other site 330214010766 G2 box; other site 330214010767 G3 box; other site 330214010768 Switch II region; other site 330214010769 G4 box; other site 330214010770 G5 box; other site 330214010771 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 330214010772 Translation-initiation factor 2; Region: IF-2; pfam11987 330214010773 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 330214010774 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 330214010775 NusA N-terminal domain; Region: NusA_N; pfam08529 330214010776 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 330214010777 RNA binding site [nucleotide binding]; other site 330214010778 homodimer interface [polypeptide binding]; other site 330214010779 NusA-like KH domain; Region: KH_5; pfam13184 330214010780 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 330214010781 G-X-X-G motif; other site 330214010782 ribosome maturation protein RimP; Reviewed; Region: PRK00092 330214010783 Sm and related proteins; Region: Sm_like; cl00259 330214010784 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 330214010785 putative oligomer interface [polypeptide binding]; other site 330214010786 putative RNA binding site [nucleotide binding]; other site 330214010787 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 330214010788 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 330214010789 homodimer interface [polypeptide binding]; other site 330214010790 substrate-cofactor binding pocket; other site 330214010791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214010792 catalytic residue [active] 330214010793 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 330214010794 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 330214010795 [2Fe-2S] cluster binding site [ion binding]; other site 330214010796 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 330214010797 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 330214010798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214010799 S-adenosylmethionine binding site [chemical binding]; other site 330214010800 FOG: CBS domain [General function prediction only]; Region: COG0517 330214010801 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 330214010802 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 330214010803 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 330214010804 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 330214010805 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 330214010806 HEAT repeats; Region: HEAT_2; pfam13646 330214010807 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 330214010808 HEAT repeats; Region: HEAT_2; pfam13646 330214010809 HEAT repeats; Region: HEAT_2; pfam13646 330214010810 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 330214010811 HEAT repeats; Region: HEAT_2; pfam13646 330214010812 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 330214010813 HEAT repeats; Region: HEAT_2; pfam13646 330214010814 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 330214010815 HEAT repeats; Region: HEAT_2; pfam13646 330214010816 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 330214010817 protein binding surface [polypeptide binding]; other site 330214010818 HEAT repeats; Region: HEAT_2; pfam13646 330214010819 HEAT repeat; Region: HEAT; pfam02985 330214010820 HEAT repeats; Region: HEAT_2; pfam13646 330214010821 HEAT repeats; Region: HEAT_2; pfam13646 330214010822 HEAT repeats; Region: HEAT_2; pfam13646 330214010823 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 330214010824 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 330214010825 HEAT repeats; Region: HEAT_2; pfam13646 330214010826 HEAT repeats; Region: HEAT_2; pfam13646 330214010827 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 330214010828 protein binding surface [polypeptide binding]; other site 330214010829 HEAT repeats; Region: HEAT_2; pfam13646 330214010830 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 330214010831 Sulfatase; Region: Sulfatase; cl17466 330214010832 LPP20 lipoprotein; Region: LPP20; cl15824 330214010833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 330214010834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 330214010835 metal binding site [ion binding]; metal-binding site 330214010836 active site 330214010837 I-site; other site 330214010838 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 330214010839 DNA polymerase I; Provisional; Region: PRK05755 330214010840 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 330214010841 active site 330214010842 metal binding site 1 [ion binding]; metal-binding site 330214010843 putative 5' ssDNA interaction site; other site 330214010844 metal binding site 3; metal-binding site 330214010845 metal binding site 2 [ion binding]; metal-binding site 330214010846 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 330214010847 putative DNA binding site [nucleotide binding]; other site 330214010848 putative metal binding site [ion binding]; other site 330214010849 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 330214010850 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 330214010851 active site 330214010852 DNA binding site [nucleotide binding] 330214010853 catalytic site [active] 330214010854 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 330214010855 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 330214010856 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 330214010857 endonuclease III; Region: ENDO3c; smart00478 330214010858 minor groove reading motif; other site 330214010859 helix-hairpin-helix signature motif; other site 330214010860 substrate binding pocket [chemical binding]; other site 330214010861 active site 330214010862 glutamate formiminotransferase; Region: FtcD; TIGR02024 330214010863 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 330214010864 Formiminotransferase domain; Region: FTCD; pfam02971 330214010865 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 330214010866 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 330214010867 CPxP motif; other site 330214010868 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 330214010869 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 330214010870 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 330214010871 [2Fe-2S] cluster binding site [ion binding]; other site 330214010872 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 330214010873 hydrophobic ligand binding site; other site 330214010874 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 330214010875 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 330214010876 TrkA-N domain; Region: TrkA_N; pfam02254 330214010877 TrkA-C domain; Region: TrkA_C; pfam02080 330214010878 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 330214010879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214010880 motif II; other site 330214010881 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 330214010882 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 330214010883 putative NAD(P) binding site [chemical binding]; other site 330214010884 active site 330214010885 putative substrate binding site [chemical binding]; other site 330214010886 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 330214010887 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 330214010888 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 330214010889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214010890 active site 330214010891 metal binding site [ion binding]; metal-binding site 330214010892 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214010893 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214010894 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 330214010895 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 330214010896 active site 330214010897 Uncharacterized conserved protein [Function unknown]; Region: COG1262 330214010898 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 330214010899 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 330214010900 Uncharacterized conserved protein [Function unknown]; Region: COG2353 330214010901 Threonine dehydrogenase; Region: TDH; cd05281 330214010902 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 330214010903 structural Zn binding site [ion binding]; other site 330214010904 catalytic Zn binding site [ion binding]; other site 330214010905 tetramer interface [polypeptide binding]; other site 330214010906 NADP binding site [chemical binding]; other site 330214010907 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 330214010908 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 330214010909 substrate-cofactor binding pocket; other site 330214010910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214010911 catalytic residue [active] 330214010912 VacJ like lipoprotein; Region: VacJ; cl01073 330214010913 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 330214010914 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 330214010915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 330214010916 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 330214010917 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 330214010918 Peptidase family M48; Region: Peptidase_M48; pfam01435 330214010919 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 330214010920 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 330214010921 HDOD domain; Region: HDOD; pfam08668 330214010922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 330214010923 Zn2+ binding site [ion binding]; other site 330214010924 Mg2+ binding site [ion binding]; other site 330214010925 Response regulator receiver domain; Region: Response_reg; pfam00072 330214010926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214010927 active site 330214010928 phosphorylation site [posttranslational modification] 330214010929 intermolecular recognition site; other site 330214010930 dimerization interface [polypeptide binding]; other site 330214010931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 330214010932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 330214010933 metal binding site [ion binding]; metal-binding site 330214010934 active site 330214010935 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 330214010936 RNA polymerase factor sigma-70; Validated; Region: PRK09047 330214010937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214010938 DNA binding residues [nucleotide binding] 330214010939 ribonuclease E; Reviewed; Region: rne; PRK10811 330214010940 ribonuclease E; Reviewed; Region: rne; PRK10811 330214010941 ribonuclease E; Reviewed; Region: rne; PRK10811 330214010942 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 330214010943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 330214010944 motif II; other site 330214010945 Conserved TM helix; Region: TM_helix; pfam05552 330214010946 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 330214010947 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 330214010948 active site 330214010949 PilZ domain; Region: PilZ; pfam07238 330214010950 PilZ domain; Region: PilZ; pfam07238 330214010951 PilZ domain; Region: PilZ; pfam07238 330214010952 Terminase small subunit; Region: Terminase_2; cl01513 330214010953 T5orf172 domain; Region: T5orf172; pfam10544 330214010954 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 330214010955 Sel1-like repeats; Region: SEL1; smart00671 330214010956 Helix-turn-helix domain; Region: HTH_17; pfam12728 330214010957 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 330214010958 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 330214010959 catalytic residues [active] 330214010960 catalytic nucleophile [active] 330214010961 Presynaptic Site I dimer interface [polypeptide binding]; other site 330214010962 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 330214010963 Synaptic Flat tetramer interface [polypeptide binding]; other site 330214010964 Synaptic Site I dimer interface [polypeptide binding]; other site 330214010965 DNA binding site [nucleotide binding] 330214010966 Recombinase; Region: Recombinase; pfam07508 330214010967 replicative DNA helicase; Region: DnaB; TIGR00665 330214010968 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 330214010969 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 330214010970 Walker A motif; other site 330214010971 ATP binding site [chemical binding]; other site 330214010972 Walker B motif; other site 330214010973 DNA binding loops [nucleotide binding] 330214010974 Helix-turn-helix domain; Region: HTH_17; cl17695 330214010975 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 330214010976 Int/Topo IB signature motif; other site 330214010977 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 330214010978 active site 330214010979 dimer interface [polypeptide binding]; other site 330214010980 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 330214010981 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 330214010982 DNA polymerase III, delta subunit; Region: holA; TIGR01128 330214010983 Lipopolysaccharide-assembly; Region: LptE; cl01125 330214010984 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 330214010985 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 330214010986 HIGH motif; other site 330214010987 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 330214010988 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 330214010989 active site 330214010990 KMSKS motif; other site 330214010991 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 330214010992 tRNA binding surface [nucleotide binding]; other site 330214010993 Methyltransferase domain; Region: Methyltransf_23; pfam13489 330214010994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214010995 S-adenosylmethionine binding site [chemical binding]; other site 330214010996 PAS domain S-box; Region: sensory_box; TIGR00229 330214010997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214010998 putative active site [active] 330214010999 heme pocket [chemical binding]; other site 330214011000 PAS domain S-box; Region: sensory_box; TIGR00229 330214011001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214011002 putative active site [active] 330214011003 heme pocket [chemical binding]; other site 330214011004 PAS domain S-box; Region: sensory_box; TIGR00229 330214011005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214011006 putative active site [active] 330214011007 heme pocket [chemical binding]; other site 330214011008 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 330214011009 GAF domain; Region: GAF; pfam01590 330214011010 PAS domain S-box; Region: sensory_box; TIGR00229 330214011011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214011012 putative active site [active] 330214011013 heme pocket [chemical binding]; other site 330214011014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 330214011015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214011016 ATP binding site [chemical binding]; other site 330214011017 Mg2+ binding site [ion binding]; other site 330214011018 G-X-G motif; other site 330214011019 Response regulator receiver domain; Region: Response_reg; pfam00072 330214011020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214011021 active site 330214011022 phosphorylation site [posttranslational modification] 330214011023 intermolecular recognition site; other site 330214011024 dimerization interface [polypeptide binding]; other site 330214011025 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 330214011026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214011027 motif II; other site 330214011028 GTP-binding protein Der; Reviewed; Region: PRK00093 330214011029 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 330214011030 G1 box; other site 330214011031 GTP/Mg2+ binding site [chemical binding]; other site 330214011032 Switch I region; other site 330214011033 G2 box; other site 330214011034 Switch II region; other site 330214011035 G3 box; other site 330214011036 G4 box; other site 330214011037 G5 box; other site 330214011038 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 330214011039 G1 box; other site 330214011040 GTP/Mg2+ binding site [chemical binding]; other site 330214011041 Switch I region; other site 330214011042 G2 box; other site 330214011043 G3 box; other site 330214011044 Switch II region; other site 330214011045 G4 box; other site 330214011046 G5 box; other site 330214011047 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 330214011048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 330214011049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 330214011050 DNA binding residues [nucleotide binding] 330214011051 Putative zinc-finger; Region: zf-HC2; pfam13490 330214011052 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 330214011053 Cytochrome c; Region: Cytochrom_C; pfam00034 330214011054 Winged helix-turn helix; Region: HTH_29; pfam13551 330214011055 Homeodomain-like domain; Region: HTH_23; pfam13384 330214011056 Integrase core domain; Region: rve; pfam00665 330214011057 PEGA domain; Region: PEGA; pfam08308 330214011058 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 330214011059 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 330214011060 putative NAD(P) binding site [chemical binding]; other site 330214011061 putative substrate binding site [chemical binding]; other site 330214011062 catalytic Zn binding site [ion binding]; other site 330214011063 structural Zn binding site [ion binding]; other site 330214011064 dimer interface [polypeptide binding]; other site 330214011065 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 330214011066 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 330214011067 Multicopper oxidase; Region: Cu-oxidase; pfam00394 330214011068 hypothetical protein; Provisional; Region: PRK08201 330214011069 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 330214011070 metal binding site [ion binding]; metal-binding site 330214011071 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 330214011072 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 330214011073 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 330214011074 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 330214011075 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 330214011076 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 330214011077 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 330214011078 hydrogenase 4 subunit F; Validated; Region: PRK06458 330214011079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214011080 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 330214011081 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 330214011082 NADH dehydrogenase; Region: NADHdh; cl00469 330214011083 hydrogenase membrane subunit; Validated; Region: PRK08667 330214011084 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214011085 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 330214011086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 330214011087 TPR motif; other site 330214011088 binding surface 330214011089 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 330214011090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 330214011091 active site 330214011092 phosphorylation site [posttranslational modification] 330214011093 intermolecular recognition site; other site 330214011094 dimerization interface [polypeptide binding]; other site 330214011095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 330214011096 Walker A motif; other site 330214011097 ATP binding site [chemical binding]; other site 330214011098 Walker B motif; other site 330214011099 arginine finger; other site 330214011100 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 330214011101 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 330214011102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 330214011103 putative active site [active] 330214011104 heme pocket [chemical binding]; other site 330214011105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 330214011106 dimer interface [polypeptide binding]; other site 330214011107 phosphorylation site [posttranslational modification] 330214011108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 330214011109 ATP binding site [chemical binding]; other site 330214011110 Mg2+ binding site [ion binding]; other site 330214011111 G-X-G motif; other site 330214011112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214011113 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 330214011114 Walker A/P-loop; other site 330214011115 ATP binding site [chemical binding]; other site 330214011116 Q-loop/lid; other site 330214011117 ABC transporter signature motif; other site 330214011118 Walker B; other site 330214011119 D-loop; other site 330214011120 H-loop/switch region; other site 330214011121 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 330214011122 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 330214011123 Peptidase family M50; Region: Peptidase_M50; pfam02163 330214011124 active site 330214011125 putative substrate binding region [chemical binding]; other site 330214011126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 330214011127 non-specific DNA binding site [nucleotide binding]; other site 330214011128 salt bridge; other site 330214011129 sequence-specific DNA binding site [nucleotide binding]; other site 330214011130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 330214011131 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 330214011132 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 330214011133 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 330214011134 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 330214011135 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 330214011136 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 330214011137 phosphoglycolate phosphatase; Provisional; Region: PRK13222 330214011138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 330214011139 active site 330214011140 motif I; other site 330214011141 motif II; other site 330214011142 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 330214011143 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 330214011144 domain interfaces; other site 330214011145 active site 330214011146 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 330214011147 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 330214011148 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 330214011149 active site 330214011150 ADP/pyrophosphate binding site [chemical binding]; other site 330214011151 dimerization interface [polypeptide binding]; other site 330214011152 allosteric effector site; other site 330214011153 fructose-1,6-bisphosphate binding site; other site 330214011154 ribonuclease; Region: Ribonuclease; pfam00545 330214011155 active site 330214011156 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 330214011157 putative RNAase interaction site [polypeptide binding]; other site 330214011158 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 330214011159 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 330214011160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 330214011161 inhibitor-cofactor binding pocket; inhibition site 330214011162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214011163 catalytic residue [active] 330214011164 Catalytic site; other site 330214011165 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 330214011166 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 330214011167 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 330214011168 active site 330214011169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 330214011170 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 330214011171 META domain; Region: META; pfam03724 330214011172 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 330214011173 amidase catalytic site [active] 330214011174 Zn binding residues [ion binding]; other site 330214011175 substrate binding site [chemical binding]; other site 330214011176 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214011177 active site 330214011178 catalytic triad [active] 330214011179 oxyanion hole [active] 330214011180 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214011181 oxyanion hole [active] 330214011182 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 330214011183 catalytic triad [active] 330214011184 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 330214011185 active site 330214011186 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 330214011187 four helix bundle protein; Region: TIGR02436 330214011188 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 330214011189 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 330214011190 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 330214011191 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 330214011192 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 330214011193 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 330214011194 dimer interface [polypeptide binding]; other site 330214011195 active site 330214011196 Uncharacterized conserved protein [Function unknown]; Region: COG1915 330214011197 SprT homologues; Region: SprT; cl01182 330214011198 SprT-like family; Region: SprT-like; pfam10263 330214011199 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 330214011200 active site 330214011201 DNA polymerase IV; Validated; Region: PRK02406 330214011202 DNA binding site [nucleotide binding] 330214011203 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 330214011204 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 330214011205 active site 330214011206 nucleotide binding site [chemical binding]; other site 330214011207 HIGH motif; other site 330214011208 KMSKS motif; other site 330214011209 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 330214011210 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 330214011211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 330214011212 ATP binding site [chemical binding]; other site 330214011213 putative Mg++ binding site [ion binding]; other site 330214011214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 330214011215 nucleotide binding region [chemical binding]; other site 330214011216 ATP-binding site [chemical binding]; other site 330214011217 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 330214011218 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 330214011219 SurA N-terminal domain; Region: SurA_N_3; cl07813 330214011220 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 330214011221 SurA N-terminal domain; Region: SurA_N; pfam09312 330214011222 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 330214011223 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 330214011224 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 330214011225 G1 box; other site 330214011226 GTP/Mg2+ binding site [chemical binding]; other site 330214011227 Switch I region; other site 330214011228 G2 box; other site 330214011229 G3 box; other site 330214011230 Switch II region; other site 330214011231 G4 box; other site 330214011232 G5 box; other site 330214011233 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 330214011234 Transglycosylase; Region: Transgly; pfam00912 330214011235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 330214011236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 330214011237 putative metal binding site [ion binding]; other site 330214011238 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 330214011239 active site 330214011240 dimer interface [polypeptide binding]; other site 330214011241 catalytic nucleophile [active] 330214011242 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 330214011243 putative active site [active] 330214011244 dimerization interface [polypeptide binding]; other site 330214011245 putative tRNAtyr binding site [nucleotide binding]; other site 330214011246 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 330214011247 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 330214011248 DNA binding site [nucleotide binding] 330214011249 active site 330214011250 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 330214011251 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 330214011252 Repair protein; Region: Repair_PSII; cl01535 330214011253 Repair protein; Region: Repair_PSII; pfam04536 330214011254 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 330214011255 PilZ domain; Region: PilZ; pfam07238 330214011256 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 330214011257 putative catalytic site [active] 330214011258 putative phosphate binding site [ion binding]; other site 330214011259 active site 330214011260 metal binding site A [ion binding]; metal-binding site 330214011261 DNA binding site [nucleotide binding] 330214011262 putative AP binding site [nucleotide binding]; other site 330214011263 putative metal binding site B [ion binding]; other site 330214011264 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 330214011265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214011266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214011267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214011268 TPR motif; other site 330214011269 binding surface 330214011270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 330214011271 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 330214011272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 330214011273 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 330214011274 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 330214011275 MEKHLA domain; Region: MEKHLA; pfam08670 330214011276 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 330214011277 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 330214011278 substrate binding site [chemical binding]; other site 330214011279 ligand binding site [chemical binding]; other site 330214011280 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 330214011281 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 330214011282 substrate binding site [chemical binding]; other site 330214011283 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 330214011284 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 330214011285 oligomer interface [polypeptide binding]; other site 330214011286 metal binding site [ion binding]; metal-binding site 330214011287 metal binding site [ion binding]; metal-binding site 330214011288 Cl binding site [ion binding]; other site 330214011289 aspartate ring; other site 330214011290 basic sphincter; other site 330214011291 putative hydrophobic gate; other site 330214011292 periplasmic entrance; other site 330214011293 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 330214011294 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 330214011295 active site 330214011296 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 330214011297 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 330214011298 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 330214011299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 330214011300 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 330214011301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 330214011302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 330214011303 homodimer interface [polypeptide binding]; other site 330214011304 catalytic residue [active] 330214011305 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 330214011306 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 330214011307 N-acetyl-D-glucosamine binding site [chemical binding]; other site 330214011308 catalytic residue [active] 330214011309 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 330214011310 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 330214011311 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 330214011312 Late embryogenesis abundant protein; Region: LEA_2; cl12118 330214011313 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 330214011314 Methyltransferase domain; Region: Methyltransf_31; pfam13847 330214011315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 330214011316 S-adenosylmethionine binding site [chemical binding]; other site 330214011317 TPR repeat; Region: TPR_11; pfam13414 330214011318 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 330214011319 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 330214011320 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 330214011321 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 330214011322 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 330214011323 Cytochrome c; Region: Cytochrom_C; pfam00034 330214011324 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 330214011325 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 330214011326 NADP binding site [chemical binding]; other site 330214011327 active site 330214011328 putative substrate binding site [chemical binding]; other site 330214011329 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 330214011330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 330214011331 NAD(P) binding site [chemical binding]; other site 330214011332 active site 330214011333 Patatin-like phospholipase; Region: Patatin; pfam01734 330214011334 active site 330214011335 nucleophile elbow; other site 330214011336 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 330214011337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214011338 Walker A/P-loop; other site 330214011339 ATP binding site [chemical binding]; other site 330214011340 Q-loop/lid; other site 330214011341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 330214011342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 330214011343 ABC transporter signature motif; other site 330214011344 Walker B; other site 330214011345 D-loop; other site 330214011346 ABC transporter; Region: ABC_tran_2; pfam12848 330214011347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 330214011348 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 330214011349 putative amphipathic alpha helix; other site 330214011350 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 330214011351 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 330214011352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 330214011353 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 330214011354 catalytic site [active] 330214011355 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 330214011356 putative hydrolase; Provisional; Region: PRK11460 330214011357 Uncharacterized conserved protein [Function unknown]; Region: COG0397 330214011358 hypothetical protein; Validated; Region: PRK00029 330214011359 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 330214011360 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 330214011361 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 330214011362 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 330214011363 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 330214011364 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 330214011365 Nitrogen regulatory protein P-II; Region: P-II; cl00412 330214011366 Nitrogen regulatory protein P-II; Region: P-II; smart00938 330214011367 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 330214011368 putative active site [active] 330214011369 homotetrameric interface [polypeptide binding]; other site 330214011370 metal binding site [ion binding]; metal-binding site 330214011371 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 330214011372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214011373 TPR motif; other site 330214011374 binding surface 330214011375 TPR repeat; Region: TPR_11; pfam13414 330214011376 TPR repeat; Region: TPR_11; pfam13414 330214011377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214011378 binding surface 330214011379 TPR motif; other site 330214011380 TPR repeat; Region: TPR_11; pfam13414 330214011381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 330214011382 binding surface 330214011383 TPR motif; other site 330214011384 Thymidylate synthase complementing protein; Region: Thy1; cl03630 330214011385 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 330214011386 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 330214011387 dimer interface [polypeptide binding]; other site 330214011388 motif 1; other site 330214011389 active site 330214011390 motif 2; other site 330214011391 motif 3; other site 330214011392 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 330214011393 anticodon binding site; other site 330214011394 DsrE/DsrF-like family; Region: DrsE; pfam02635 330214011395 DsrE/DsrF-like family; Region: DrsE; cl00672