-- dump date 20140619_024514 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1002672000001 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1002672000002 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1002672000003 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1002672000004 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1002672000005 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1002672000006 putative valine binding site [chemical binding]; other site 1002672000007 dimer interface [polypeptide binding]; other site 1002672000008 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1002672000009 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1002672000010 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1002672000011 PYR/PP interface [polypeptide binding]; other site 1002672000012 dimer interface [polypeptide binding]; other site 1002672000013 TPP binding site [chemical binding]; other site 1002672000014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1002672000015 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1002672000016 TPP-binding site [chemical binding]; other site 1002672000017 dimer interface [polypeptide binding]; other site 1002672000018 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1002672000019 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1002672000020 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1002672000021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1002672000022 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1002672000023 protein binding site [polypeptide binding]; other site 1002672000024 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1002672000025 protein binding site [polypeptide binding]; other site 1002672000026 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1002672000027 FtsH protease regulator HflC; Provisional; Region: PRK11029 1002672000028 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1002672000029 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1002672000030 HflK protein; Region: hflK; TIGR01933 1002672000031 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1002672000032 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1002672000033 Walker A motif; other site 1002672000034 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1002672000035 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1002672000036 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1002672000037 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1002672000038 tartrate dehydrogenase; Region: TTC; TIGR02089 1002672000039 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 1002672000040 metal binding site [ion binding]; metal-binding site 1002672000041 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1002672000042 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1002672000043 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1002672000044 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1002672000045 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1002672000046 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1002672000047 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1002672000048 EamA-like transporter family; Region: EamA; pfam00892 1002672000049 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1002672000050 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1002672000051 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1002672000052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1002672000053 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1002672000054 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1002672000055 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1002672000056 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1002672000057 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1002672000058 ligand binding site [chemical binding]; other site 1002672000059 homodimer interface [polypeptide binding]; other site 1002672000060 NAD(P) binding site [chemical binding]; other site 1002672000061 trimer interface B [polypeptide binding]; other site 1002672000062 trimer interface A [polypeptide binding]; other site 1002672000063 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1002672000064 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1002672000065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000066 NAD(P) binding site [chemical binding]; other site 1002672000067 active site 1002672000068 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1002672000069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1002672000070 active site 1002672000071 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 1002672000072 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1002672000073 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000074 active site 1002672000075 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1002672000076 O-Antigen ligase; Region: Wzy_C; pfam04932 1002672000077 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1002672000078 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1002672000079 Ligand binding site; other site 1002672000080 Putative Catalytic site; other site 1002672000081 DXD motif; other site 1002672000082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000083 active site 1002672000084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000085 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1002672000086 NAD(P) binding site [chemical binding]; other site 1002672000087 active site 1002672000088 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1002672000089 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1002672000090 Ligand Binding Site [chemical binding]; other site 1002672000091 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 1002672000092 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672000093 phosphate binding site [ion binding]; other site 1002672000094 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1002672000095 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1002672000096 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1002672000097 putative trimer interface [polypeptide binding]; other site 1002672000098 putative CoA binding site [chemical binding]; other site 1002672000099 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1002672000100 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1002672000101 inhibitor-cofactor binding pocket; inhibition site 1002672000102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672000103 catalytic residue [active] 1002672000104 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1002672000105 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1002672000106 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1002672000107 NAD(P) binding pocket [chemical binding]; other site 1002672000108 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1002672000109 Ligand binding site; other site 1002672000110 Putative Catalytic site; other site 1002672000111 DXD motif; other site 1002672000112 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1002672000113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000114 NAD(P) binding site [chemical binding]; other site 1002672000115 active site 1002672000116 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1002672000117 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1002672000118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1002672000119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1002672000120 Protein of unknown function (DUF1420); Region: DUF1420; pfam07220 1002672000121 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1002672000122 active site 1002672000123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000124 active site 1002672000125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1002672000127 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1002672000128 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1002672000129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1002672000130 WxcM-like, C-terminal; Region: FdtA; pfam05523 1002672000131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672000132 S-adenosylmethionine binding site [chemical binding]; other site 1002672000133 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1002672000134 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 1002672000135 metal binding site [ion binding]; metal-binding site 1002672000136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000137 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1002672000138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000139 NAD(P) binding site [chemical binding]; other site 1002672000140 active site 1002672000141 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1002672000142 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000143 active site 1002672000144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000146 active site 1002672000147 potential frameshift: common BLAST hit: gi|33864960|ref|NP_896519.1| HMGL-like family protein 1002672000148 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1002672000149 metal binding site [ion binding]; metal-binding site 1002672000150 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1002672000151 active site 1002672000152 catalytic residues [active] 1002672000153 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1002672000154 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1002672000155 catalytic residue [active] 1002672000156 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1002672000157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1002672000158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1002672000159 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1002672000160 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 1002672000161 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 1002672000162 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1002672000163 Amidase; Region: Amidase; cl11426 1002672000164 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 1002672000165 Ligand Binding Site [chemical binding]; other site 1002672000166 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1002672000167 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1002672000168 Ligand binding site; other site 1002672000169 Putative Catalytic site; other site 1002672000170 DXD motif; other site 1002672000171 potential frameshift: common BLAST hit: gi|320160046|ref|YP_004173270.1| N-acetylneuraminate synthase 1002672000172 NeuB family; Region: NeuB; pfam03102 1002672000173 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1002672000174 NeuB family; Region: NeuB; pfam03102 1002672000175 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1002672000176 ligand binding site; other site 1002672000177 tetramer interface; other site 1002672000178 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1002672000179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000180 NAD(P) binding site [chemical binding]; other site 1002672000181 active site 1002672000182 flagellin modification protein A; Provisional; Region: PRK09186 1002672000183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000184 NAD(P) binding site [chemical binding]; other site 1002672000185 active site 1002672000186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000187 active site 1002672000188 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1002672000189 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672000190 phosphate binding site [ion binding]; other site 1002672000191 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1002672000192 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1002672000193 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1002672000194 Ligand Binding Site [chemical binding]; other site 1002672000195 potential frameshift: common BLAST hit: gi|256828180|ref|YP_003156908.1| Nucleotidyl transferase 1002672000196 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1002672000197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000198 active site 1002672000199 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1002672000200 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1002672000201 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1002672000202 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1002672000203 active site 1002672000204 substrate binding site [chemical binding]; other site 1002672000205 cosubstrate binding site; other site 1002672000206 catalytic site [active] 1002672000207 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1002672000208 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1002672000209 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1002672000210 homodimer interface [polypeptide binding]; other site 1002672000211 active site 1002672000212 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1002672000213 NeuB family; Region: NeuB; pfam03102 1002672000214 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1002672000215 NeuB binding interface [polypeptide binding]; other site 1002672000216 putative substrate binding site [chemical binding]; other site 1002672000217 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1002672000218 putative trimer interface [polypeptide binding]; other site 1002672000219 putative CoA binding site [chemical binding]; other site 1002672000220 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1002672000221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1002672000222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1002672000223 catalytic residue [active] 1002672000224 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1002672000225 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 1002672000226 NAD binding site [chemical binding]; other site 1002672000227 substrate binding site [chemical binding]; other site 1002672000228 active site 1002672000229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1002672000230 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1002672000231 Walker A/P-loop; other site 1002672000232 ATP binding site [chemical binding]; other site 1002672000233 Q-loop/lid; other site 1002672000234 ABC transporter signature motif; other site 1002672000235 Walker B; other site 1002672000236 D-loop; other site 1002672000237 H-loop/switch region; other site 1002672000238 hypothetical protein; Provisional; Region: PRK05849 1002672000239 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1002672000240 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1002672000241 conserved cys residue [active] 1002672000242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672000243 active site 1002672000244 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1002672000245 active site 1002672000246 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1002672000247 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1002672000248 Peptidase family M23; Region: Peptidase_M23; pfam01551 1002672000249 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1002672000250 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1002672000251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672000252 S-adenosylmethionine binding site [chemical binding]; other site 1002672000253 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1002672000254 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1002672000255 RF-1 domain; Region: RF-1; pfam00472 1002672000256 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1002672000257 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1002672000258 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1002672000259 aspartate kinase; Reviewed; Region: PRK06635 1002672000260 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1002672000261 putative nucleotide binding site [chemical binding]; other site 1002672000262 putative catalytic residues [active] 1002672000263 putative Mg ion binding site [ion binding]; other site 1002672000264 putative aspartate binding site [chemical binding]; other site 1002672000265 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1002672000266 putative allosteric regulatory site; other site 1002672000267 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1002672000268 putative allosteric regulatory residue; other site 1002672000269 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1002672000270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672000271 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 1002672000272 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1002672000273 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1002672000274 active site 1002672000275 8-oxo-dGMP binding site [chemical binding]; other site 1002672000276 nudix motif; other site 1002672000277 metal binding site [ion binding]; metal-binding site 1002672000278 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1002672000279 heterotetramer interface [polypeptide binding]; other site 1002672000280 active site pocket [active] 1002672000281 cleavage site 1002672000282 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1002672000283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1002672000284 ATP binding site [chemical binding]; other site 1002672000285 putative Mg++ binding site [ion binding]; other site 1002672000286 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1002672000287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1002672000288 nucleotide binding region [chemical binding]; other site 1002672000289 ATP-binding site [chemical binding]; other site 1002672000290 SEC-C motif; Region: SEC-C; pfam02810 1002672000291 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1002672000292 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1002672000293 malate synthase G; Provisional; Region: PRK02999 1002672000294 active site 1002672000295 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1002672000296 ADP binding site [chemical binding]; other site 1002672000297 magnesium binding site [ion binding]; other site 1002672000298 putative shikimate binding site; other site 1002672000299 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1002672000300 active site 1002672000301 dimer interface [polypeptide binding]; other site 1002672000302 metal binding site [ion binding]; metal-binding site 1002672000303 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1002672000304 Domain of unknown function DUF21; Region: DUF21; pfam01595 1002672000305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1002672000306 Transporter associated domain; Region: CorC_HlyC; smart01091 1002672000307 BolA-like protein; Region: BolA; cl00386 1002672000308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1002672000309 HSP70 interaction site [polypeptide binding]; other site 1002672000310 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1002672000311 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1002672000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1002672000313 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1002672000314 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 1002672000315 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1002672000316 metal ion-dependent adhesion site (MIDAS); other site 1002672000317 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1002672000318 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1002672000319 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1002672000320 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1002672000321 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1002672000322 quinone interaction residues [chemical binding]; other site 1002672000323 active site 1002672000324 catalytic residues [active] 1002672000325 FMN binding site [chemical binding]; other site 1002672000326 substrate binding site [chemical binding]; other site 1002672000327 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1002672000328 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672000329 active site 1002672000330 nucleotide binding site [chemical binding]; other site 1002672000331 HIGH motif; other site 1002672000332 KMSKS motif; other site 1002672000333 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1002672000334 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1002672000335 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1002672000336 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1002672000337 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1002672000338 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1002672000339 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1002672000340 inhibitor-cofactor binding pocket; inhibition site 1002672000341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672000342 catalytic residue [active] 1002672000343 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1002672000344 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1002672000345 GcrA cell cycle regulator; Region: GcrA; cl11564 1002672000346 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1002672000347 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672000348 EamA-like transporter family; Region: EamA; pfam00892 1002672000349 EamA-like transporter family; Region: EamA; cl17759 1002672000350 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1002672000351 EamA-like transporter family; Region: EamA; cl17759 1002672000352 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1002672000353 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 1002672000354 putative active site [active] 1002672000355 metal binding site [ion binding]; metal-binding site 1002672000356 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1002672000357 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1002672000358 NAD(P) binding site [chemical binding]; other site 1002672000359 catalytic residues [active] 1002672000360 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1002672000361 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1002672000362 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1002672000363 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1002672000364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1002672000365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1002672000366 dimerization interface [polypeptide binding]; other site 1002672000367 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1002672000368 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 1002672000369 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1002672000370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000371 dimer interface [polypeptide binding]; other site 1002672000372 conserved gate region; other site 1002672000373 putative PBP binding loops; other site 1002672000374 ABC-ATPase subunit interface; other site 1002672000375 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1002672000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000377 dimer interface [polypeptide binding]; other site 1002672000378 conserved gate region; other site 1002672000379 ABC-ATPase subunit interface; other site 1002672000380 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1002672000381 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1002672000382 Walker A/P-loop; other site 1002672000383 ATP binding site [chemical binding]; other site 1002672000384 Q-loop/lid; other site 1002672000385 ABC transporter signature motif; other site 1002672000386 Walker B; other site 1002672000387 D-loop; other site 1002672000388 H-loop/switch region; other site 1002672000389 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1002672000390 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1002672000391 substrate binding pocket [chemical binding]; other site 1002672000392 membrane-bound complex binding site; other site 1002672000393 hinge residues; other site 1002672000394 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1002672000395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672000396 motif II; other site 1002672000397 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1002672000398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1002672000399 Walker A/P-loop; other site 1002672000400 ATP binding site [chemical binding]; other site 1002672000401 Q-loop/lid; other site 1002672000402 ABC transporter signature motif; other site 1002672000403 Walker B; other site 1002672000404 D-loop; other site 1002672000405 H-loop/switch region; other site 1002672000406 TOBE domain; Region: TOBE_2; pfam08402 1002672000407 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1002672000408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000409 dimer interface [polypeptide binding]; other site 1002672000410 conserved gate region; other site 1002672000411 putative PBP binding loops; other site 1002672000412 ABC-ATPase subunit interface; other site 1002672000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000414 dimer interface [polypeptide binding]; other site 1002672000415 conserved gate region; other site 1002672000416 putative PBP binding loops; other site 1002672000417 ABC-ATPase subunit interface; other site 1002672000418 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1002672000419 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1002672000420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1002672000421 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1002672000422 putative hydrolase; Provisional; Region: PRK02113 1002672000423 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1002672000424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1002672000425 dimer interface [polypeptide binding]; other site 1002672000426 phosphorylation site [posttranslational modification] 1002672000427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672000428 ATP binding site [chemical binding]; other site 1002672000429 Mg2+ binding site [ion binding]; other site 1002672000430 G-X-G motif; other site 1002672000431 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1002672000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1002672000433 active site 1002672000434 phosphorylation site [posttranslational modification] 1002672000435 intermolecular recognition site; other site 1002672000436 dimerization interface [polypeptide binding]; other site 1002672000437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1002672000438 DNA binding site [nucleotide binding] 1002672000439 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1002672000440 PhoU domain; Region: PhoU; pfam01895 1002672000441 PhoU domain; Region: PhoU; pfam01895 1002672000442 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1002672000443 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1002672000444 Walker A/P-loop; other site 1002672000445 ATP binding site [chemical binding]; other site 1002672000446 Q-loop/lid; other site 1002672000447 ABC transporter signature motif; other site 1002672000448 Walker B; other site 1002672000449 D-loop; other site 1002672000450 H-loop/switch region; other site 1002672000451 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1002672000452 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1002672000453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000454 dimer interface [polypeptide binding]; other site 1002672000455 conserved gate region; other site 1002672000456 putative PBP binding loops; other site 1002672000457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1002672000458 ABC-ATPase subunit interface; other site 1002672000459 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1002672000460 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1002672000461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000462 dimer interface [polypeptide binding]; other site 1002672000463 conserved gate region; other site 1002672000464 putative PBP binding loops; other site 1002672000465 ABC-ATPase subunit interface; other site 1002672000466 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1002672000467 Predicted membrane protein [Function unknown]; Region: COG2259 1002672000468 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1002672000469 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1002672000470 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 1002672000471 ligand binding surface [chemical binding]; other site 1002672000472 Autotransporter beta-domain; Region: Autotransporter; smart00869 1002672000473 Autotransporter beta-domain; Region: Autotransporter; smart00869 1002672000474 CHASE2 domain; Region: CHASE2; pfam05226 1002672000475 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1002672000476 Autotransporter beta-domain; Region: Autotransporter; smart00869 1002672000477 Autotransporter beta-domain; Region: Autotransporter; smart00869 1002672000478 FecR protein; Region: FecR; pfam04773 1002672000479 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1002672000480 anti sigma factor interaction site; other site 1002672000481 regulatory phosphorylation site [posttranslational modification]; other site 1002672000482 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1002672000483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1002672000484 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1002672000485 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1002672000486 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1002672000487 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1002672000488 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1002672000489 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1002672000490 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1002672000491 Walker A motif; other site 1002672000492 ATP binding site [chemical binding]; other site 1002672000493 Walker B motif; other site 1002672000494 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1002672000495 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1002672000496 Competence protein A; Region: Competence_A; pfam11104 1002672000497 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1002672000498 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1002672000499 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1002672000500 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1002672000501 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1002672000502 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1002672000503 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1002672000504 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1002672000505 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 1002672000506 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1002672000507 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1002672000508 Walker A motif; other site 1002672000509 ATP binding site [chemical binding]; other site 1002672000510 Walker B motif; other site 1002672000511 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1002672000512 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1002672000513 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1002672000514 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1002672000515 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1002672000516 putative active site pocket [active] 1002672000517 putative metal binding site [ion binding]; other site 1002672000518 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1002672000519 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1002672000520 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1002672000521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1002672000522 DNA-binding site [nucleotide binding]; DNA binding site 1002672000523 FCD domain; Region: FCD; pfam07729 1002672000524 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1002672000525 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1002672000526 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1002672000527 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1002672000528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1002672000529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672000530 NAD(P) binding site [chemical binding]; other site 1002672000531 active site 1002672000532 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1002672000533 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1002672000534 tetramer interface [polypeptide binding]; other site 1002672000535 active site 1002672000536 Mg2+/Mn2+ binding site [ion binding]; other site 1002672000537 DctM-like transporters; Region: DctM; pfam06808 1002672000538 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1002672000539 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1002672000540 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1002672000541 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1002672000542 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1002672000543 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1002672000544 dimer interface [polypeptide binding]; other site 1002672000545 TPP-binding site [chemical binding]; other site 1002672000546 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1002672000547 Niemann-Pick C type protein family; Region: 2A060601; TIGR00917 1002672000548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1002672000549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1002672000550 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1002672000551 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1002672000552 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1002672000553 homodimer interface [polypeptide binding]; other site 1002672000554 substrate-cofactor binding pocket; other site 1002672000555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672000556 catalytic residue [active] 1002672000557 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1002672000558 L-aspartate oxidase; Provisional; Region: PRK06175 1002672000559 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1002672000560 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1002672000561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1002672000562 binding surface 1002672000563 TPR motif; other site 1002672000564 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1002672000565 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1002672000566 active site 1002672000567 iron coordination sites [ion binding]; other site 1002672000568 substrate binding pocket [chemical binding]; other site 1002672000569 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1002672000570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1002672000571 active site residue [active] 1002672000572 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1002672000573 active site 1002672000574 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1002672000575 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1002672000576 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 1002672000577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672000578 dimer interface [polypeptide binding]; other site 1002672000579 conserved gate region; other site 1002672000580 putative PBP binding loops; other site 1002672000581 ABC-ATPase subunit interface; other site 1002672000582 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1002672000583 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1002672000584 substrate binding pocket [chemical binding]; other site 1002672000585 membrane-bound complex binding site; other site 1002672000586 hinge residues; other site 1002672000587 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1002672000588 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1002672000589 homodimer interface [polypeptide binding]; other site 1002672000590 substrate-cofactor binding pocket; other site 1002672000591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672000592 catalytic residue [active] 1002672000593 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1002672000594 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1002672000595 NADP binding site [chemical binding]; other site 1002672000596 homodimer interface [polypeptide binding]; other site 1002672000597 active site 1002672000598 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1002672000599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1002672000600 FeS/SAM binding site; other site 1002672000601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1002672000602 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1002672000603 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 1002672000604 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1002672000605 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1002672000606 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1002672000607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1002672000608 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1002672000609 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1002672000610 catalytic residues [active] 1002672000611 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1002672000612 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1002672000613 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1002672000614 putative active site [active] 1002672000615 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1002672000616 HSP70 interaction site [polypeptide binding]; other site 1002672000617 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1002672000618 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1002672000619 glutathione synthetase; Provisional; Region: PRK05246 1002672000620 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1002672000621 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1002672000622 glutamate--cysteine ligase; Region: PLN02611 1002672000623 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1002672000624 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1002672000625 inhibitor-cofactor binding pocket; inhibition site 1002672000626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672000627 catalytic residue [active] 1002672000628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1002672000629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1002672000630 putative substrate translocation pore; other site 1002672000631 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1002672000632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1002672000633 active site 1002672000634 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1002672000635 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1002672000636 endonuclease III; Region: ENDO3c; smart00478 1002672000637 minor groove reading motif; other site 1002672000638 helix-hairpin-helix signature motif; other site 1002672000639 substrate binding pocket [chemical binding]; other site 1002672000640 active site 1002672000641 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672000642 EamA-like transporter family; Region: EamA; cl17759 1002672000643 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1002672000644 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1002672000645 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1002672000646 active site residue [active] 1002672000647 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1002672000648 active site residue [active] 1002672000649 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1002672000650 HlyD family secretion protein; Region: HlyD_3; pfam13437 1002672000651 potential frameshift: common BLAST hit: gi|170726531|ref|YP_001760557.1| acriflavin resistance protein 1002672000652 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1002672000653 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1002672000654 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1002672000655 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1002672000656 catalytic residue [active] 1002672000657 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1002672000658 catalytic core [active] 1002672000659 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1002672000660 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1002672000661 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1002672000662 Substrate binding site; other site 1002672000663 metal-binding site 1002672000664 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1002672000665 Phosphotransferase enzyme family; Region: APH; pfam01636 1002672000666 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1002672000667 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1002672000668 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1002672000669 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1002672000670 homotetramer interface [polypeptide binding]; other site 1002672000671 ligand binding site [chemical binding]; other site 1002672000672 catalytic site [active] 1002672000673 NAD binding site [chemical binding]; other site 1002672000674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1002672000675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1002672000676 dimer interface [polypeptide binding]; other site 1002672000677 phosphorylation site [posttranslational modification] 1002672000678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672000679 ATP binding site [chemical binding]; other site 1002672000680 Mg2+ binding site [ion binding]; other site 1002672000681 G-X-G motif; other site 1002672000682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1002672000683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1002672000684 active site 1002672000685 phosphorylation site [posttranslational modification] 1002672000686 intermolecular recognition site; other site 1002672000687 dimerization interface [polypeptide binding]; other site 1002672000688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1002672000689 DNA binding site [nucleotide binding] 1002672000690 DNA polymerase I; Provisional; Region: PRK05755 1002672000691 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1002672000692 active site 1002672000693 metal binding site 1 [ion binding]; metal-binding site 1002672000694 putative 5' ssDNA interaction site; other site 1002672000695 metal binding site 3; metal-binding site 1002672000696 metal binding site 2 [ion binding]; metal-binding site 1002672000697 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1002672000698 putative DNA binding site [nucleotide binding]; other site 1002672000699 putative metal binding site [ion binding]; other site 1002672000700 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1002672000701 active site 1002672000702 catalytic site [active] 1002672000703 substrate binding site [chemical binding]; other site 1002672000704 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1002672000705 active site 1002672000706 DNA binding site [nucleotide binding] 1002672000707 catalytic site [active] 1002672000708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1002672000709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1002672000710 Walker A/P-loop; other site 1002672000711 ATP binding site [chemical binding]; other site 1002672000712 Q-loop/lid; other site 1002672000713 ABC transporter signature motif; other site 1002672000714 Walker B; other site 1002672000715 D-loop; other site 1002672000716 H-loop/switch region; other site 1002672000717 BioY family; Region: BioY; pfam02632 1002672000718 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1002672000719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1002672000720 active site 1002672000721 phosphorylation site [posttranslational modification] 1002672000722 intermolecular recognition site; other site 1002672000723 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1002672000724 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1002672000725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1002672000726 dimer interface [polypeptide binding]; other site 1002672000727 active site 1002672000728 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1002672000729 catalytic residues [active] 1002672000730 substrate binding site [chemical binding]; other site 1002672000731 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 1002672000732 deoxyhypusine synthase; Region: dhys; TIGR00321 1002672000733 potential frameshift: common BLAST hit: gi|212219054|ref|YP_002305841.1| agmatinase 1002672000734 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1002672000735 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1002672000736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1002672000737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1002672000738 phosphorylation site [posttranslational modification] 1002672000739 dimer interface [polypeptide binding]; other site 1002672000740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672000741 ATP binding site [chemical binding]; other site 1002672000742 Mg2+ binding site [ion binding]; other site 1002672000743 G-X-G motif; other site 1002672000744 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1002672000745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672000746 Mg2+ binding site [ion binding]; other site 1002672000747 G-X-G motif; other site 1002672000748 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1002672000749 anchoring element; other site 1002672000750 dimer interface [polypeptide binding]; other site 1002672000751 ATP binding site [chemical binding]; other site 1002672000752 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1002672000753 active site 1002672000754 metal binding site [ion binding]; metal-binding site 1002672000755 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1002672000756 recombination protein F; Reviewed; Region: recF; PRK00064 1002672000757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1002672000758 ABC transporter signature motif; other site 1002672000759 Walker B; other site 1002672000760 D-loop; other site 1002672000761 H-loop/switch region; other site 1002672000762 DNA polymerase III subunit beta; Validated; Region: PRK05643 1002672000763 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1002672000764 putative DNA binding surface [nucleotide binding]; other site 1002672000765 dimer interface [polypeptide binding]; other site 1002672000766 beta-clamp/clamp loader binding surface; other site 1002672000767 beta-clamp/translesion DNA polymerase binding surface; other site 1002672000768 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1002672000769 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1002672000770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672000771 Walker A motif; other site 1002672000772 ATP binding site [chemical binding]; other site 1002672000773 Walker B motif; other site 1002672000774 arginine finger; other site 1002672000775 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1002672000776 DnaA box-binding interface [nucleotide binding]; other site 1002672000777 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1002672000778 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1002672000779 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1002672000780 DNA binding site [nucleotide binding] 1002672000781 catalytic residue [active] 1002672000782 H2TH interface [polypeptide binding]; other site 1002672000783 putative catalytic residues [active] 1002672000784 turnover-facilitating residue; other site 1002672000785 intercalation triad [nucleotide binding]; other site 1002672000786 8OG recognition residue [nucleotide binding]; other site 1002672000787 putative reading head residues; other site 1002672000788 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1002672000789 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1002672000790 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1002672000791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672000792 S-adenosylmethionine binding site [chemical binding]; other site 1002672000793 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1002672000794 ABC1 family; Region: ABC1; cl17513 1002672000795 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1002672000796 Flavoprotein; Region: Flavoprotein; pfam02441 1002672000797 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1002672000798 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1002672000799 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1002672000800 trimer interface [polypeptide binding]; other site 1002672000801 active site 1002672000802 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1002672000803 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1002672000804 ATP binding site [chemical binding]; other site 1002672000805 substrate interface [chemical binding]; other site 1002672000806 Bacterial SH3 domain; Region: SH3_4; pfam06347 1002672000807 Bacterial SH3 domain; Region: SH3_4; pfam06347 1002672000808 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 1002672000809 active site 2 [active] 1002672000810 active site 1 [active] 1002672000811 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1002672000812 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1002672000813 dimer interface [polypeptide binding]; other site 1002672000814 active site 1002672000815 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1002672000816 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1002672000817 NAD binding site [chemical binding]; other site 1002672000818 homotetramer interface [polypeptide binding]; other site 1002672000819 homodimer interface [polypeptide binding]; other site 1002672000820 substrate binding site [chemical binding]; other site 1002672000821 active site 1002672000822 SelR domain; Region: SelR; pfam01641 1002672000823 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1002672000824 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1002672000825 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1002672000826 RNase E interface [polypeptide binding]; other site 1002672000827 trimer interface [polypeptide binding]; other site 1002672000828 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1002672000829 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1002672000830 RNase E interface [polypeptide binding]; other site 1002672000831 trimer interface [polypeptide binding]; other site 1002672000832 active site 1002672000833 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1002672000834 putative nucleic acid binding region [nucleotide binding]; other site 1002672000835 G-X-X-G motif; other site 1002672000836 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1002672000837 RNA binding site [nucleotide binding]; other site 1002672000838 domain interface; other site 1002672000839 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1002672000840 16S/18S rRNA binding site [nucleotide binding]; other site 1002672000841 S13e-L30e interaction site [polypeptide binding]; other site 1002672000842 25S rRNA binding site [nucleotide binding]; other site 1002672000843 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1002672000844 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1002672000845 RNA binding site [nucleotide binding]; other site 1002672000846 active site 1002672000847 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1002672000848 translation initiation factor IF-2; Region: IF-2; TIGR00487 1002672000849 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1002672000850 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1002672000851 G1 box; other site 1002672000852 putative GEF interaction site [polypeptide binding]; other site 1002672000853 GTP/Mg2+ binding site [chemical binding]; other site 1002672000854 Switch I region; other site 1002672000855 G2 box; other site 1002672000856 G3 box; other site 1002672000857 Switch II region; other site 1002672000858 G4 box; other site 1002672000859 G5 box; other site 1002672000860 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1002672000861 Translation-initiation factor 2; Region: IF-2; pfam11987 1002672000862 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1002672000863 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1002672000864 NusA N-terminal domain; Region: NusA_N; pfam08529 1002672000865 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1002672000866 RNA binding site [nucleotide binding]; other site 1002672000867 homodimer interface [polypeptide binding]; other site 1002672000868 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1002672000869 G-X-X-G motif; other site 1002672000870 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1002672000871 G-X-X-G motif; other site 1002672000872 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1002672000873 Putative methyltransferase; Region: Methyltransf_4; cl17290 1002672000874 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1002672000875 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1002672000876 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1002672000877 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1002672000878 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1002672000879 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1002672000880 putative active site [active] 1002672000881 catalytic triad [active] 1002672000882 putative dimer interface [polypeptide binding]; other site 1002672000883 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1002672000884 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1002672000885 Transporter associated domain; Region: CorC_HlyC; smart01091 1002672000886 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1002672000887 PhoH-like protein; Region: PhoH; pfam02562 1002672000888 AAA domain; Region: AAA_22; pfam13401 1002672000889 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1002672000890 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1002672000891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1002672000892 FeS/SAM binding site; other site 1002672000893 TRAM domain; Region: TRAM; cl01282 1002672000894 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1002672000895 metal binding site 2 [ion binding]; metal-binding site 1002672000896 putative DNA binding helix; other site 1002672000897 metal binding site 1 [ion binding]; metal-binding site 1002672000898 dimer interface [polypeptide binding]; other site 1002672000899 structural Zn2+ binding site [ion binding]; other site 1002672000900 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1002672000901 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 1002672000902 putative active site [active] 1002672000903 putative metal binding site [ion binding]; other site 1002672000904 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1002672000905 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1002672000906 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1002672000907 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1002672000908 Ligand Binding Site [chemical binding]; other site 1002672000909 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1002672000910 active site 1002672000911 HIGH motif; other site 1002672000912 dimer interface [polypeptide binding]; other site 1002672000913 KMSKS motif; other site 1002672000914 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1002672000915 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1002672000916 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1002672000917 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1002672000918 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1002672000919 putative NAD(P) binding site [chemical binding]; other site 1002672000920 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1002672000921 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1002672000922 BON domain; Region: BON; pfam04972 1002672000923 Predicted methyltransferases [General function prediction only]; Region: COG0313 1002672000924 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1002672000925 putative SAM binding site [chemical binding]; other site 1002672000926 putative homodimer interface [polypeptide binding]; other site 1002672000927 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1002672000928 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1002672000929 active site 1002672000930 dimerization interface [polypeptide binding]; other site 1002672000931 ribonuclease PH; Reviewed; Region: rph; PRK00173 1002672000932 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1002672000933 hexamer interface [polypeptide binding]; other site 1002672000934 active site 1002672000935 GrpE; Region: GrpE; pfam01025 1002672000936 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1002672000937 dimer interface [polypeptide binding]; other site 1002672000938 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1002672000939 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1002672000940 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1002672000941 nucleotide binding site [chemical binding]; other site 1002672000942 NEF interaction site [polypeptide binding]; other site 1002672000943 SBD interface [polypeptide binding]; other site 1002672000944 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1002672000945 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1002672000946 HSP70 interaction site [polypeptide binding]; other site 1002672000947 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1002672000948 Zn binding sites [ion binding]; other site 1002672000949 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1002672000950 dimer interface [polypeptide binding]; other site 1002672000951 argininosuccinate synthase; Provisional; Region: PRK13820 1002672000952 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1002672000953 ANP binding site [chemical binding]; other site 1002672000954 Substrate Binding Site II [chemical binding]; other site 1002672000955 Substrate Binding Site I [chemical binding]; other site 1002672000956 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1002672000957 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1002672000958 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1002672000959 homodimer interface [polypeptide binding]; other site 1002672000960 NADP binding site [chemical binding]; other site 1002672000961 substrate binding site [chemical binding]; other site 1002672000962 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1002672000963 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1002672000964 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1002672000965 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1002672000966 active site 1002672000967 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1002672000968 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1002672000969 domain interfaces; other site 1002672000970 active site 1002672000971 UGMP family protein; Validated; Region: PRK09604 1002672000972 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1002672000973 UGMP family protein; Validated; Region: PRK09604 1002672000974 EVE domain; Region: EVE; pfam01878 1002672000975 acetyl-CoA synthetase; Provisional; Region: PRK00174 1002672000976 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1002672000977 active site 1002672000978 CoA binding site [chemical binding]; other site 1002672000979 acyl-activating enzyme (AAE) consensus motif; other site 1002672000980 AMP binding site [chemical binding]; other site 1002672000981 acetate binding site [chemical binding]; other site 1002672000982 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1002672000983 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1002672000984 putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647 1002672000985 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1002672000986 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1002672000987 Na binding site [ion binding]; other site 1002672000988 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1002672000989 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1002672000990 hexamer interface [polypeptide binding]; other site 1002672000991 metal binding site [ion binding]; metal-binding site 1002672000992 substrate binding site [chemical binding]; other site 1002672000993 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1002672000994 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1002672000995 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1002672000996 purine monophosphate binding site [chemical binding]; other site 1002672000997 dimer interface [polypeptide binding]; other site 1002672000998 putative catalytic residues [active] 1002672000999 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1002672001000 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1002672001001 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1002672001002 aromatic arch; other site 1002672001003 DCoH dimer interaction site [polypeptide binding]; other site 1002672001004 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1002672001005 DCoH tetramer interaction site [polypeptide binding]; other site 1002672001006 substrate binding site [chemical binding]; other site 1002672001007 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1002672001008 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1002672001009 Trm112p-like protein; Region: Trm112p; cl01066 1002672001010 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1002672001011 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1002672001012 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1002672001013 RNA binding site [nucleotide binding]; other site 1002672001014 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1002672001015 multimer interface [polypeptide binding]; other site 1002672001016 Walker A motif; other site 1002672001017 ATP binding site [chemical binding]; other site 1002672001018 Walker B motif; other site 1002672001019 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1002672001020 ferrochelatase; Reviewed; Region: hemH; PRK00035 1002672001021 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1002672001022 C-terminal domain interface [polypeptide binding]; other site 1002672001023 active site 1002672001024 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1002672001025 active site 1002672001026 N-terminal domain interface [polypeptide binding]; other site 1002672001027 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1002672001028 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1002672001029 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1002672001030 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1002672001031 Maf-like protein; Region: Maf; pfam02545 1002672001032 active site 1002672001033 dimer interface [polypeptide binding]; other site 1002672001034 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1002672001035 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1002672001036 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1002672001037 shikimate binding site; other site 1002672001038 NAD(P) binding site [chemical binding]; other site 1002672001039 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1002672001040 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1002672001041 CoA-binding site [chemical binding]; other site 1002672001042 ATP-binding [chemical binding]; other site 1002672001043 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1002672001044 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1002672001045 active site 1002672001046 catalytic site [active] 1002672001047 substrate binding site [chemical binding]; other site 1002672001048 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 1002672001049 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1002672001050 Tim44-like domain; Region: Tim44; pfam04280 1002672001051 Smr domain; Region: Smr; pfam01713 1002672001052 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1002672001053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672001054 Walker A motif; other site 1002672001055 ATP binding site [chemical binding]; other site 1002672001056 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1002672001057 Walker B motif; other site 1002672001058 arginine finger; other site 1002672001059 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1002672001060 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1002672001061 active site 1002672001062 HslU subunit interaction site [polypeptide binding]; other site 1002672001063 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1002672001064 putative active site pocket [active] 1002672001065 4-fold oligomerization interface [polypeptide binding]; other site 1002672001066 metal binding residues [ion binding]; metal-binding site 1002672001067 3-fold/trimer interface [polypeptide binding]; other site 1002672001068 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1002672001069 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1002672001070 putative active site [active] 1002672001071 oxyanion strand; other site 1002672001072 catalytic triad [active] 1002672001073 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1002672001074 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1002672001075 catalytic residues [active] 1002672001076 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1002672001077 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1002672001078 substrate binding site [chemical binding]; other site 1002672001079 glutamase interaction surface [polypeptide binding]; other site 1002672001080 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1002672001081 metal binding site [ion binding]; metal-binding site 1002672001082 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1002672001083 nucleotide binding site/active site [active] 1002672001084 HIT family signature motif; other site 1002672001085 catalytic residue [active] 1002672001086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1002672001087 Coenzyme A binding pocket [chemical binding]; other site 1002672001088 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1002672001089 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1002672001090 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1002672001091 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1002672001092 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1002672001093 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1002672001094 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1002672001095 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1002672001096 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1002672001097 G1 box; other site 1002672001098 GTP/Mg2+ binding site [chemical binding]; other site 1002672001099 Switch I region; other site 1002672001100 G2 box; other site 1002672001101 Switch II region; other site 1002672001102 G3 box; other site 1002672001103 G4 box; other site 1002672001104 G5 box; other site 1002672001105 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1002672001106 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1002672001107 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1002672001108 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1002672001109 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1002672001110 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1002672001111 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1002672001112 P-loop; other site 1002672001113 Magnesium ion binding site [ion binding]; other site 1002672001114 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1002672001115 Magnesium ion binding site [ion binding]; other site 1002672001116 ParB-like nuclease domain; Region: ParBc; pfam02195 1002672001117 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1002672001118 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1002672001119 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1002672001120 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1002672001121 HIGH motif; other site 1002672001122 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1002672001123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672001124 active site 1002672001125 KMSKS motif; other site 1002672001126 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1002672001127 tRNA binding surface [nucleotide binding]; other site 1002672001128 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1002672001129 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1002672001130 active site 1002672001131 thiamine phosphate binding site [chemical binding]; other site 1002672001132 pyrophosphate binding site [ion binding]; other site 1002672001133 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1002672001134 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1002672001135 catalytic residue [active] 1002672001136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1002672001137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1002672001138 DNA binding site [nucleotide binding] 1002672001139 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1002672001140 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1002672001141 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1002672001142 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1002672001143 substrate binding site [chemical binding]; other site 1002672001144 ATP binding site [chemical binding]; other site 1002672001145 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1002672001146 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1002672001147 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1002672001148 minor groove reading motif; other site 1002672001149 helix-hairpin-helix signature motif; other site 1002672001150 substrate binding pocket [chemical binding]; other site 1002672001151 active site 1002672001152 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1002672001153 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1002672001154 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1002672001155 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 1002672001156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1002672001157 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1002672001158 active site 1002672001159 catalytic tetrad [active] 1002672001160 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1002672001161 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1002672001162 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1002672001163 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 1002672001164 Intracellular septation protein A; Region: IspA; pfam04279 1002672001165 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 1002672001166 heme exporter protein CcmC; Region: ccmC; TIGR01191 1002672001167 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1002672001168 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1002672001169 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1002672001170 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1002672001171 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1002672001172 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672001173 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1002672001174 phosphate binding site [ion binding]; other site 1002672001175 aspartate aminotransferase; Provisional; Region: PRK05764 1002672001176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1002672001177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672001178 homodimer interface [polypeptide binding]; other site 1002672001179 catalytic residue [active] 1002672001180 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1002672001181 FAD binding domain; Region: FAD_binding_4; pfam01565 1002672001182 FAD binding domain; Region: FAD_binding_4; pfam01565 1002672001183 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1002672001184 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1002672001185 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1002672001186 Cysteine-rich domain; Region: CCG; pfam02754 1002672001187 Cysteine-rich domain; Region: CCG; pfam02754 1002672001188 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1002672001189 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1002672001190 dimerization interface [polypeptide binding]; other site 1002672001191 ligand binding site [chemical binding]; other site 1002672001192 NADP binding site [chemical binding]; other site 1002672001193 catalytic site [active] 1002672001194 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1002672001195 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1002672001196 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1002672001197 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1002672001198 DctM-like transporters; Region: DctM; pfam06808 1002672001199 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1002672001200 Amidase; Region: Amidase; cl11426 1002672001201 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672001202 EamA-like transporter family; Region: EamA; pfam00892 1002672001203 EamA-like transporter family; Region: EamA; pfam00892 1002672001204 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1002672001205 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1002672001206 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1002672001207 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1002672001208 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1002672001209 P loop; other site 1002672001210 GTP binding site [chemical binding]; other site 1002672001211 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1002672001212 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1002672001213 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1002672001214 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1002672001215 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1002672001216 P loop; other site 1002672001217 GTP binding site [chemical binding]; other site 1002672001218 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1002672001219 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1002672001220 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1002672001221 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1002672001222 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1002672001223 substrate binding site [chemical binding]; other site 1002672001224 ligand binding site [chemical binding]; other site 1002672001225 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1002672001226 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1002672001227 hypothetical protein; Provisional; Region: PRK14812 1002672001228 substrate binding site [chemical binding]; other site 1002672001229 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1002672001230 tartrate dehydrogenase; Region: TTC; TIGR02089 1002672001231 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1002672001232 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1002672001233 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1002672001234 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1002672001235 Iron-sulfur protein interface; other site 1002672001236 proximal heme binding site [chemical binding]; other site 1002672001237 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1002672001238 L-aspartate oxidase; Provisional; Region: PRK06175 1002672001239 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1002672001240 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1002672001241 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1002672001242 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1002672001243 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1002672001244 tetrameric interface [polypeptide binding]; other site 1002672001245 NAD binding site [chemical binding]; other site 1002672001246 catalytic residues [active] 1002672001247 malate dehydrogenase; Reviewed; Region: PRK06223 1002672001248 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1002672001249 NAD(P) binding site [chemical binding]; other site 1002672001250 dimer interface [polypeptide binding]; other site 1002672001251 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1002672001252 substrate binding site [chemical binding]; other site 1002672001253 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1002672001254 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1002672001255 CoA-ligase; Region: Ligase_CoA; pfam00549 1002672001256 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1002672001257 CoA binding domain; Region: CoA_binding; pfam02629 1002672001258 CoA-ligase; Region: Ligase_CoA; pfam00549 1002672001259 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1002672001260 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1002672001261 TPP-binding site [chemical binding]; other site 1002672001262 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1002672001263 dimer interface [polypeptide binding]; other site 1002672001264 PYR/PP interface [polypeptide binding]; other site 1002672001265 TPP binding site [chemical binding]; other site 1002672001266 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1002672001267 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1002672001268 E3 interaction surface; other site 1002672001269 lipoyl attachment site [posttranslational modification]; other site 1002672001270 e3 binding domain; Region: E3_binding; pfam02817 1002672001271 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1002672001272 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1002672001273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1002672001274 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1002672001275 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1002672001276 active site 1002672001277 intersubunit interactions; other site 1002672001278 catalytic residue [active] 1002672001279 primosome assembly protein PriA; Validated; Region: PRK05580 1002672001280 primosomal protein N' Region: priA; TIGR00595 1002672001281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1002672001282 putative Mg++ binding site [ion binding]; other site 1002672001283 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1002672001284 nucleotide binding region [chemical binding]; other site 1002672001285 ATP-binding site [chemical binding]; other site 1002672001286 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1002672001287 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1002672001288 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1002672001289 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1002672001290 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1002672001291 beta subunit interaction interface [polypeptide binding]; other site 1002672001292 Walker A motif; other site 1002672001293 ATP binding site [chemical binding]; other site 1002672001294 Walker B motif; other site 1002672001295 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1002672001296 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1002672001297 core domain interface [polypeptide binding]; other site 1002672001298 delta subunit interface [polypeptide binding]; other site 1002672001299 epsilon subunit interface [polypeptide binding]; other site 1002672001300 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1002672001301 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1002672001302 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1002672001303 alpha subunit interaction interface [polypeptide binding]; other site 1002672001304 Walker A motif; other site 1002672001305 ATP binding site [chemical binding]; other site 1002672001306 Walker B motif; other site 1002672001307 inhibitor binding site; inhibition site 1002672001308 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1002672001309 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 1002672001310 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1002672001311 gamma subunit interface [polypeptide binding]; other site 1002672001312 epsilon subunit interface [polypeptide binding]; other site 1002672001313 LBP interface [polypeptide binding]; other site 1002672001314 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1002672001315 putative active site [active] 1002672001316 Ap4A binding site [chemical binding]; other site 1002672001317 nudix motif; other site 1002672001318 putative metal binding site [ion binding]; other site 1002672001319 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1002672001320 C-terminal peptidase (prc); Region: prc; TIGR00225 1002672001321 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1002672001322 protein binding site [polypeptide binding]; other site 1002672001323 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1002672001324 Catalytic dyad [active] 1002672001325 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1002672001326 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1002672001327 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1002672001328 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1002672001329 active site 1002672001330 (T/H)XGH motif; other site 1002672001331 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1002672001332 putative catalytic cysteine [active] 1002672001333 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1002672001334 gamma-glutamyl kinase; Provisional; Region: PRK05429 1002672001335 homotetrameric interface [polypeptide binding]; other site 1002672001336 putative phosphate binding site [ion binding]; other site 1002672001337 putative allosteric binding site; other site 1002672001338 nucleotide binding site [chemical binding]; other site 1002672001339 PUA domain; Region: PUA; pfam01472 1002672001340 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1002672001341 GTP1/OBG; Region: GTP1_OBG; pfam01018 1002672001342 Obg GTPase; Region: Obg; cd01898 1002672001343 G1 box; other site 1002672001344 GTP/Mg2+ binding site [chemical binding]; other site 1002672001345 Switch I region; other site 1002672001346 G2 box; other site 1002672001347 G3 box; other site 1002672001348 Switch II region; other site 1002672001349 G4 box; other site 1002672001350 G5 box; other site 1002672001351 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1002672001352 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1002672001353 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1002672001354 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1002672001355 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1002672001356 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1002672001357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672001358 S-adenosylmethionine binding site [chemical binding]; other site 1002672001359 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1002672001360 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1002672001361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1002672001362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672001363 homodimer interface [polypeptide binding]; other site 1002672001364 catalytic residue [active] 1002672001365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1002672001366 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1002672001367 prephenate dehydrogenase; Validated; Region: PRK08507 1002672001368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1002672001369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1002672001370 putative acyl-acceptor binding pocket; other site 1002672001371 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1002672001372 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1002672001373 active site 1002672001374 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1002672001375 substrate binding site [chemical binding]; other site 1002672001376 catalytic residues [active] 1002672001377 dimer interface [polypeptide binding]; other site 1002672001378 argininosuccinate lyase; Provisional; Region: PRK00855 1002672001379 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1002672001380 active sites [active] 1002672001381 tetramer interface [polypeptide binding]; other site 1002672001382 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1002672001383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1002672001384 catalytic residues [active] 1002672001385 putative hydrolase; Provisional; Region: PRK11460 1002672001386 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1002672001387 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1002672001388 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1002672001389 active site 1002672001390 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1002672001391 diiron binding motif [ion binding]; other site 1002672001392 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1002672001393 Predicted membrane protein [Function unknown]; Region: COG1238 1002672001394 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1002672001395 acyl-activating enzyme (AAE) consensus motif; other site 1002672001396 CoA binding site [chemical binding]; other site 1002672001397 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1002672001398 AMP binding site [chemical binding]; other site 1002672001399 active site 1002672001400 CoA binding site [chemical binding]; other site 1002672001401 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1002672001402 Ferredoxin [Energy production and conversion]; Region: COG1146 1002672001403 4Fe-4S binding domain; Region: Fer4; pfam00037 1002672001404 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1002672001405 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1002672001406 putative metal binding site [ion binding]; other site 1002672001407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1002672001408 nucleotide binding region [chemical binding]; other site 1002672001409 ATP-binding site [chemical binding]; other site 1002672001410 Acylphosphatase; Region: Acylphosphatase; pfam00708 1002672001411 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1002672001412 NlpC/P60 family; Region: NLPC_P60; cl17555 1002672001413 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1002672001414 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 1002672001415 Na binding site [ion binding]; other site 1002672001416 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1002672001417 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1002672001418 pseudo EF-hand loop; other site 1002672001419 peptide binding pocket; other site 1002672001420 Ca2+ binding site [ion binding]; other site 1002672001421 muropeptide transporter; Validated; Region: ampG; cl17669 1002672001422 muropeptide transporter; Validated; Region: ampG; cl17669 1002672001423 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1002672001424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672001425 active site 1002672001426 prephenate dehydratase; Provisional; Region: PRK11899 1002672001427 Prephenate dehydratase; Region: PDT; pfam00800 1002672001428 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1002672001429 putative L-Phe binding site [chemical binding]; other site 1002672001430 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1002672001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672001432 Walker A motif; other site 1002672001433 ATP binding site [chemical binding]; other site 1002672001434 Walker B motif; other site 1002672001435 arginine finger; other site 1002672001436 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1002672001437 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1002672001438 hypothetical protein; Validated; Region: PRK00153 1002672001439 recombination protein RecR; Reviewed; Region: recR; PRK00076 1002672001440 RecR protein; Region: RecR; pfam02132 1002672001441 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1002672001442 putative active site [active] 1002672001443 putative metal-binding site [ion binding]; other site 1002672001444 tetramer interface [polypeptide binding]; other site 1002672001445 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1002672001446 active site 1002672001447 catalytic residues [active] 1002672001448 metal binding site [ion binding]; metal-binding site 1002672001449 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1002672001450 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1002672001451 putative active site [active] 1002672001452 substrate binding site [chemical binding]; other site 1002672001453 putative cosubstrate binding site; other site 1002672001454 catalytic site [active] 1002672001455 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1002672001456 substrate binding site [chemical binding]; other site 1002672001457 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1002672001458 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1002672001459 dimerization interface 3.5A [polypeptide binding]; other site 1002672001460 active site 1002672001461 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1002672001462 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1002672001463 metal binding site [ion binding]; metal-binding site 1002672001464 dimer interface [polypeptide binding]; other site 1002672001465 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1002672001466 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1002672001467 trimer interface [polypeptide binding]; other site 1002672001468 active site 1002672001469 substrate binding site [chemical binding]; other site 1002672001470 CoA binding site [chemical binding]; other site 1002672001471 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1002672001472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672001473 active site 1002672001474 motif I; other site 1002672001475 motif II; other site 1002672001476 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1002672001477 homohexameric interface [polypeptide binding]; other site 1002672001478 feedback inhibition sensing region; other site 1002672001479 nucleotide binding site [chemical binding]; other site 1002672001480 N-acetyl-L-glutamate binding site [chemical binding]; other site 1002672001481 membrane protein insertase; Provisional; Region: PRK01318 1002672001482 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1002672001483 Haemolytic domain; Region: Haemolytic; cl00506 1002672001484 Ribonuclease P; Region: Ribonuclease_P; cl00457 1002672001485 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1002672001486 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1002672001487 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1002672001488 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1002672001489 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1002672001490 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1002672001491 LrgA family; Region: LrgA; pfam03788 1002672001492 LrgB-like family; Region: LrgB; pfam04172 1002672001493 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1002672001494 Fe-S cluster binding site [ion binding]; other site 1002672001495 DNA binding site [nucleotide binding] 1002672001496 active site 1002672001497 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1002672001498 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1002672001499 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1002672001500 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1002672001501 DNA-binding site [nucleotide binding]; DNA binding site 1002672001502 RNA-binding motif; other site 1002672001503 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1002672001504 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1002672001505 G1 box; other site 1002672001506 putative GEF interaction site [polypeptide binding]; other site 1002672001507 GTP/Mg2+ binding site [chemical binding]; other site 1002672001508 Switch I region; other site 1002672001509 G2 box; other site 1002672001510 G3 box; other site 1002672001511 Switch II region; other site 1002672001512 G4 box; other site 1002672001513 G5 box; other site 1002672001514 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1002672001515 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1002672001516 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1002672001517 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1002672001518 substrate-cofactor binding pocket; other site 1002672001519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672001520 catalytic residue [active] 1002672001521 Membrane transport protein; Region: Mem_trans; cl09117 1002672001522 hypothetical protein; Provisional; Region: PRK09272 1002672001523 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1002672001524 hypothetical protein; Validated; Region: PRK00029 1002672001525 glutathione reductase; Validated; Region: PRK06116 1002672001526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1002672001527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1002672001528 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1002672001529 RmuC family; Region: RmuC; pfam02646 1002672001530 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1002672001531 exonuclease I; Provisional; Region: sbcB; PRK11779 1002672001532 active site 1002672001533 catalytic site [active] 1002672001534 substrate binding site [chemical binding]; other site 1002672001535 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1002672001536 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1002672001537 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1002672001538 catalytic residues [active] 1002672001539 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1002672001540 Ligand binding site; other site 1002672001541 Putative Catalytic site; other site 1002672001542 DXD motif; other site 1002672001543 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1002672001544 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1002672001545 catalytic core [active] 1002672001546 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1002672001547 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1002672001548 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1002672001549 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1002672001550 active site 1002672001551 heterodimer interface [polypeptide binding]; other site 1002672001552 substrate binding site [chemical binding]; other site 1002672001553 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672001554 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1002672001555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1002672001556 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1002672001557 active site 1002672001558 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1002672001559 active site 1002672001560 dimer interface [polypeptide binding]; other site 1002672001561 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1002672001562 IHF - DNA interface [nucleotide binding]; other site 1002672001563 IHF dimer interface [polypeptide binding]; other site 1002672001564 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1002672001565 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1002672001566 RNA binding site [nucleotide binding]; other site 1002672001567 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1002672001568 RNA binding site [nucleotide binding]; other site 1002672001569 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1002672001570 RNA binding site [nucleotide binding]; other site 1002672001571 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1002672001572 RNA binding site [nucleotide binding]; other site 1002672001573 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1002672001574 RNA binding site [nucleotide binding]; other site 1002672001575 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1002672001576 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1002672001577 putative active site [active] 1002672001578 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 1002672001579 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1002672001580 CMP-binding site; other site 1002672001581 The sites determining sugar specificity; other site 1002672001582 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1002672001583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1002672001584 ABC transporter; Region: ABC_tran; pfam00005 1002672001585 Q-loop/lid; other site 1002672001586 ABC transporter signature motif; other site 1002672001587 Walker B; other site 1002672001588 D-loop; other site 1002672001589 H-loop/switch region; other site 1002672001590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1002672001591 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1002672001592 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1002672001593 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1002672001594 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1002672001595 catalytic site [active] 1002672001596 putative active site [active] 1002672001597 putative substrate binding site [chemical binding]; other site 1002672001598 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1002672001599 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1002672001600 putative NAD(P) binding site [chemical binding]; other site 1002672001601 active site 1002672001602 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1002672001603 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1002672001604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1002672001605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1002672001606 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1002672001607 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1002672001608 active site 1002672001609 dimer interface [polypeptide binding]; other site 1002672001610 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1002672001611 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1002672001612 active site 1002672001613 FMN binding site [chemical binding]; other site 1002672001614 substrate binding site [chemical binding]; other site 1002672001615 3Fe-4S cluster binding site [ion binding]; other site 1002672001616 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1002672001617 domain interface; other site 1002672001618 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1002672001619 putative NAD(P) binding site [chemical binding]; other site 1002672001620 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1002672001621 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1002672001622 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 1002672001623 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1002672001624 putative ADP-binding pocket [chemical binding]; other site 1002672001625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1002672001626 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1002672001627 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1002672001628 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1002672001629 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1002672001630 active site 1002672001631 dimer interface [polypeptide binding]; other site 1002672001632 motif 1; other site 1002672001633 motif 2; other site 1002672001634 motif 3; other site 1002672001635 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1002672001636 anticodon binding site; other site 1002672001637 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1002672001638 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1002672001639 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1002672001640 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1002672001641 23S rRNA binding site [nucleotide binding]; other site 1002672001642 L21 binding site [polypeptide binding]; other site 1002672001643 L13 binding site [polypeptide binding]; other site 1002672001644 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1002672001645 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1002672001646 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1002672001647 dimer interface [polypeptide binding]; other site 1002672001648 motif 1; other site 1002672001649 active site 1002672001650 motif 2; other site 1002672001651 motif 3; other site 1002672001652 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1002672001653 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1002672001654 putative tRNA-binding site [nucleotide binding]; other site 1002672001655 B3/4 domain; Region: B3_4; pfam03483 1002672001656 tRNA synthetase B5 domain; Region: B5; smart00874 1002672001657 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1002672001658 dimer interface [polypeptide binding]; other site 1002672001659 motif 1; other site 1002672001660 motif 3; other site 1002672001661 motif 2; other site 1002672001662 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1002672001663 GTP-binding protein LepA; Provisional; Region: PRK05433 1002672001664 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1002672001665 G1 box; other site 1002672001666 putative GEF interaction site [polypeptide binding]; other site 1002672001667 GTP/Mg2+ binding site [chemical binding]; other site 1002672001668 Switch I region; other site 1002672001669 G2 box; other site 1002672001670 G3 box; other site 1002672001671 Switch II region; other site 1002672001672 G4 box; other site 1002672001673 G5 box; other site 1002672001674 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1002672001675 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1002672001676 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1002672001677 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1002672001678 extended (e) SDRs; Region: SDR_e; cd08946 1002672001679 NAD(P) binding site [chemical binding]; other site 1002672001680 active site 1002672001681 substrate binding site [chemical binding]; other site 1002672001682 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1002672001683 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1002672001684 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672001685 active site 1002672001686 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1002672001687 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1002672001688 Beta-lactamase; Region: Beta-lactamase; pfam00144 1002672001689 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1002672001690 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1002672001691 E3 interaction surface; other site 1002672001692 lipoyl attachment site [posttranslational modification]; other site 1002672001693 e3 binding domain; Region: E3_binding; pfam02817 1002672001694 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1002672001695 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1002672001696 E3 interaction surface; other site 1002672001697 lipoyl attachment site [posttranslational modification]; other site 1002672001698 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1002672001699 E3 interaction surface; other site 1002672001700 lipoyl attachment site [posttranslational modification]; other site 1002672001701 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1002672001702 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1002672001703 dimer interface [polypeptide binding]; other site 1002672001704 TPP-binding site [chemical binding]; other site 1002672001705 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1002672001706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1002672001707 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1002672001708 tetramerization interface [polypeptide binding]; other site 1002672001709 NAD(P) binding site [chemical binding]; other site 1002672001710 catalytic residues [active] 1002672001711 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1002672001712 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1002672001713 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1002672001714 DNA-binding site [nucleotide binding]; DNA binding site 1002672001715 RNA-binding motif; other site 1002672001716 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1002672001717 trimer interface [polypeptide binding]; other site 1002672001718 active site 1002672001719 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1002672001720 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1002672001721 hinge; other site 1002672001722 active site 1002672001723 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 1002672001724 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1002672001725 histidinol dehydrogenase; Region: hisD; TIGR00069 1002672001726 NAD binding site [chemical binding]; other site 1002672001727 dimerization interface [polypeptide binding]; other site 1002672001728 product binding site; other site 1002672001729 substrate binding site [chemical binding]; other site 1002672001730 zinc binding site [ion binding]; other site 1002672001731 catalytic residues [active] 1002672001732 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1002672001733 rRNA binding site [nucleotide binding]; other site 1002672001734 predicted 30S ribosome binding site; other site 1002672001735 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1002672001736 putative active site [active] 1002672001737 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1002672001738 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1002672001739 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1002672001740 dimer interface [polypeptide binding]; other site 1002672001741 motif 1; other site 1002672001742 active site 1002672001743 motif 2; other site 1002672001744 motif 3; other site 1002672001745 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1002672001746 anticodon binding site; other site 1002672001747 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1002672001748 motif 1; other site 1002672001749 dimer interface [polypeptide binding]; other site 1002672001750 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 1002672001751 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1002672001752 active site 1002672001753 motif 3; other site 1002672001754 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1002672001755 ATP phosphoribosyltransferase; Region: HisG; cl15266 1002672001756 MAPEG family; Region: MAPEG; cl09190 1002672001757 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1002672001758 putative active site pocket [active] 1002672001759 dimerization interface [polypeptide binding]; other site 1002672001760 putative catalytic residue [active] 1002672001761 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1002672001762 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1002672001763 ring oligomerisation interface [polypeptide binding]; other site 1002672001764 ATP/Mg binding site [chemical binding]; other site 1002672001765 stacking interactions; other site 1002672001766 hinge regions; other site 1002672001767 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1002672001768 oligomerisation interface [polypeptide binding]; other site 1002672001769 mobile loop; other site 1002672001770 roof hairpin; other site 1002672001771 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 1002672001772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672001773 active site 1002672001774 motif I; other site 1002672001775 motif II; other site 1002672001776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672001777 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1002672001778 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1002672001779 active site 1002672001780 Riboflavin kinase; Region: Flavokinase; pfam01687 1002672001781 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1002672001782 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672001783 active site 1002672001784 HIGH motif; other site 1002672001785 nucleotide binding site [chemical binding]; other site 1002672001786 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1002672001787 active site 1002672001788 KMSKS motif; other site 1002672001789 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1002672001790 tRNA binding surface [nucleotide binding]; other site 1002672001791 anticodon binding site; other site 1002672001792 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1002672001793 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 1002672001794 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 1002672001795 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1002672001796 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1002672001797 dimer interface [polypeptide binding]; other site 1002672001798 active site 1002672001799 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1002672001800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672001801 S-adenosylmethionine binding site [chemical binding]; other site 1002672001802 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1002672001803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1002672001804 RNA binding surface [nucleotide binding]; other site 1002672001805 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1002672001806 active site 1002672001807 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1002672001808 nucleoside/Zn binding site; other site 1002672001809 dimer interface [polypeptide binding]; other site 1002672001810 catalytic motif [active] 1002672001811 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1002672001812 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1002672001813 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1002672001814 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1002672001815 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1002672001816 generic binding surface II; other site 1002672001817 generic binding surface I; other site 1002672001818 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 1002672001819 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 1002672001820 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1002672001821 Peptidase family M23; Region: Peptidase_M23; pfam01551 1002672001822 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1002672001823 putative acyl-acceptor binding pocket; other site 1002672001824 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1002672001825 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1002672001826 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1002672001827 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1002672001828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1002672001829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1002672001830 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1002672001831 Walker A/P-loop; other site 1002672001832 ATP binding site [chemical binding]; other site 1002672001833 Q-loop/lid; other site 1002672001834 ABC transporter signature motif; other site 1002672001835 Walker B; other site 1002672001836 D-loop; other site 1002672001837 H-loop/switch region; other site 1002672001838 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1002672001839 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1002672001840 UbiA prenyltransferase family; Region: UbiA; pfam01040 1002672001841 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1002672001842 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1002672001843 RNA methyltransferase, RsmE family; Region: TIGR00046 1002672001844 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1002672001845 protease TldD; Provisional; Region: tldD; PRK10735 1002672001846 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1002672001847 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00117 1002672001848 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1002672001849 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1002672001850 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1002672001851 Subunit I/III interface [polypeptide binding]; other site 1002672001852 D-pathway; other site 1002672001853 Subunit I/VIIc interface [polypeptide binding]; other site 1002672001854 Subunit I/IV interface [polypeptide binding]; other site 1002672001855 Subunit I/II interface [polypeptide binding]; other site 1002672001856 Low-spin heme (heme a) binding site [chemical binding]; other site 1002672001857 Subunit I/VIIa interface [polypeptide binding]; other site 1002672001858 Subunit I/VIa interface [polypeptide binding]; other site 1002672001859 Dimer interface; other site 1002672001860 Putative water exit pathway; other site 1002672001861 Binuclear center (heme a3/CuB) [ion binding]; other site 1002672001862 K-pathway; other site 1002672001863 Subunit I/Vb interface [polypeptide binding]; other site 1002672001864 Putative proton exit pathway; other site 1002672001865 Subunit I/VIb interface; other site 1002672001866 Subunit I/VIc interface [polypeptide binding]; other site 1002672001867 Electron transfer pathway; other site 1002672001868 Subunit I/VIIIb interface [polypeptide binding]; other site 1002672001869 Subunit I/VIIb interface [polypeptide binding]; other site 1002672001870 FOG: CBS domain [General function prediction only]; Region: COG0517 1002672001871 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1002672001872 Predicted small integral membrane protein [Function unknown]; Region: COG5605 1002672001873 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 1002672001874 Subunit I/III interface [polypeptide binding]; other site 1002672001875 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1002672001876 Subunit I/III interface [polypeptide binding]; other site 1002672001877 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1002672001878 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1002672001879 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1002672001880 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1002672001881 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1002672001882 UbiA prenyltransferase family; Region: UbiA; pfam01040 1002672001883 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1002672001884 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1002672001885 Subunit III/VIIa interface [polypeptide binding]; other site 1002672001886 Phospholipid binding site [chemical binding]; other site 1002672001887 Subunit I/III interface [polypeptide binding]; other site 1002672001888 Subunit III/VIb interface [polypeptide binding]; other site 1002672001889 Subunit III/VIa interface; other site 1002672001890 Subunit III/Vb interface [polypeptide binding]; other site 1002672001891 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1002672001892 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1002672001893 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1002672001894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672001895 catalytic residue [active] 1002672001896 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1002672001897 RNA/DNA hybrid binding site [nucleotide binding]; other site 1002672001898 active site 1002672001899 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1002672001900 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1002672001901 putative active site [active] 1002672001902 putative substrate binding site [chemical binding]; other site 1002672001903 ATP binding site [chemical binding]; other site 1002672001904 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1002672001905 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1002672001906 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 1002672001907 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 1002672001908 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1002672001909 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1002672001910 aspartate-rich region 2; other site 1002672001911 substrate-Mg2+ binding site; other site 1002672001912 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1002672001913 substrate binding pocket [chemical binding]; other site 1002672001914 aspartate-rich region 1; other site 1002672001915 phytoene desaturase; Region: crtI_fam; TIGR02734 1002672001916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1002672001917 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1002672001918 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1002672001919 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 1002672001920 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1002672001921 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1002672001922 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1002672001923 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1002672001924 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1002672001925 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1002672001926 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1002672001927 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1002672001928 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1002672001929 Walker A/P-loop; other site 1002672001930 ATP binding site [chemical binding]; other site 1002672001931 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1002672001932 ABC transporter signature motif; other site 1002672001933 Walker B; other site 1002672001934 D-loop; other site 1002672001935 H-loop/switch region; other site 1002672001936 Thioredoxin; Region: Thioredoxin_4; cl17273 1002672001937 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1002672001938 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1002672001939 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1002672001940 minor groove reading motif; other site 1002672001941 helix-hairpin-helix signature motif; other site 1002672001942 substrate binding pocket [chemical binding]; other site 1002672001943 active site 1002672001944 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1002672001945 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1002672001946 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1002672001947 DNA methylase; Region: N6_N4_Mtase; pfam01555 1002672001948 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1002672001949 RNA/DNA hybrid binding site [nucleotide binding]; other site 1002672001950 active site 1002672001951 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1002672001952 active site 1002672001953 Fe-S cluster binding site [ion binding]; other site 1002672001954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1002672001955 binding surface 1002672001956 TPR repeat; Region: TPR_11; pfam13414 1002672001957 TPR motif; other site 1002672001958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1002672001959 binding surface 1002672001960 TPR motif; other site 1002672001961 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 1002672001962 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1002672001963 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1002672001964 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1002672001965 active site 1002672001966 NTP binding site [chemical binding]; other site 1002672001967 metal binding triad [ion binding]; metal-binding site 1002672001968 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1002672001969 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1002672001970 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1002672001971 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1002672001972 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 1002672001973 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1002672001974 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1002672001975 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1002672001976 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1002672001977 [2Fe-2S] cluster binding site [ion binding]; other site 1002672001978 cytochrome b; Provisional; Region: CYTB; MTH00191 1002672001979 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1002672001980 Qi binding site; other site 1002672001981 intrachain domain interface; other site 1002672001982 interchain domain interface [polypeptide binding]; other site 1002672001983 heme bH binding site [chemical binding]; other site 1002672001984 heme bL binding site [chemical binding]; other site 1002672001985 Qo binding site; other site 1002672001986 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1002672001987 interchain domain interface [polypeptide binding]; other site 1002672001988 intrachain domain interface; other site 1002672001989 Qi binding site; other site 1002672001990 Qo binding site; other site 1002672001991 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1002672001992 GTP-binding protein YchF; Reviewed; Region: PRK09601 1002672001993 YchF GTPase; Region: YchF; cd01900 1002672001994 Switch I region; other site 1002672001995 G2 box; other site 1002672001996 Switch II region; other site 1002672001997 G3 box; other site 1002672001998 GTP/Mg2+ binding site [chemical binding]; other site 1002672001999 G4 box; other site 1002672002000 G5 box; other site 1002672002001 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1002672002002 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1002672002003 putative active site [active] 1002672002004 catalytic residue [active] 1002672002005 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1002672002006 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1002672002007 5S rRNA interface [nucleotide binding]; other site 1002672002008 CTC domain interface [polypeptide binding]; other site 1002672002009 L16 interface [polypeptide binding]; other site 1002672002010 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1002672002011 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1002672002012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1002672002013 active site 1002672002014 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1002672002015 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1002672002016 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1002672002017 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1002672002018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1002672002019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1002672002020 dimer interface [polypeptide binding]; other site 1002672002021 phosphorylation site [posttranslational modification] 1002672002022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672002023 ATP binding site [chemical binding]; other site 1002672002024 Mg2+ binding site [ion binding]; other site 1002672002025 G-X-G motif; other site 1002672002026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1002672002027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1002672002028 active site 1002672002029 phosphorylation site [posttranslational modification] 1002672002030 intermolecular recognition site; other site 1002672002031 dimerization interface [polypeptide binding]; other site 1002672002032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1002672002033 DNA binding site [nucleotide binding] 1002672002034 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1002672002035 MarR family; Region: MarR_2; pfam12802 1002672002036 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1002672002037 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1002672002038 homodimer interface [polypeptide binding]; other site 1002672002039 substrate-cofactor binding pocket; other site 1002672002040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002041 catalytic residue [active] 1002672002042 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1002672002043 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1002672002044 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1002672002045 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1002672002046 GIY-YIG motif/motif A; other site 1002672002047 active site 1002672002048 catalytic site [active] 1002672002049 putative DNA binding site [nucleotide binding]; other site 1002672002050 metal binding site [ion binding]; metal-binding site 1002672002051 UvrB/uvrC motif; Region: UVR; pfam02151 1002672002052 Dihydroneopterin aldolase; Region: FolB; pfam02152 1002672002053 active site 1002672002054 short chain dehydrogenase; Provisional; Region: PRK09134 1002672002055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672002056 NAD(P) binding site [chemical binding]; other site 1002672002057 active site 1002672002058 excinuclease ABC subunit B; Provisional; Region: PRK05298 1002672002059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1002672002060 ATP binding site [chemical binding]; other site 1002672002061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1002672002062 nucleotide binding region [chemical binding]; other site 1002672002063 ATP-binding site [chemical binding]; other site 1002672002064 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1002672002065 UvrB/uvrC motif; Region: UVR; pfam02151 1002672002066 aspartate aminotransferase; Provisional; Region: PRK05764 1002672002067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1002672002068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002069 homodimer interface [polypeptide binding]; other site 1002672002070 catalytic residue [active] 1002672002071 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1002672002072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1002672002073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1002672002074 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1002672002075 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1002672002076 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1002672002077 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1002672002078 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1002672002079 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1002672002080 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1002672002081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1002672002082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1002672002083 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1002672002084 IMP binding site; other site 1002672002085 dimer interface [polypeptide binding]; other site 1002672002086 interdomain contacts; other site 1002672002087 partial ornithine binding site; other site 1002672002088 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1002672002089 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1002672002090 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1002672002091 catalytic site [active] 1002672002092 subunit interface [polypeptide binding]; other site 1002672002093 Yqey-like protein; Region: YqeY; pfam09424 1002672002094 DNA primase, catalytic core; Region: dnaG; TIGR01391 1002672002095 CHC2 zinc finger; Region: zf-CHC2; cl17510 1002672002096 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1002672002097 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1002672002098 active site 1002672002099 metal binding site [ion binding]; metal-binding site 1002672002100 interdomain interaction site; other site 1002672002101 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1002672002102 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1002672002103 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1002672002104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1002672002105 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1002672002106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1002672002107 DNA binding residues [nucleotide binding] 1002672002108 EamA-like transporter family; Region: EamA; pfam00892 1002672002109 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1002672002110 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1002672002111 VacJ like lipoprotein; Region: VacJ; cl01073 1002672002112 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1002672002113 amidase catalytic site [active] 1002672002114 Zn binding residues [ion binding]; other site 1002672002115 substrate binding site [chemical binding]; other site 1002672002116 cell division protein MraZ; Reviewed; Region: PRK00326 1002672002117 MraZ protein; Region: MraZ; pfam02381 1002672002118 MraZ protein; Region: MraZ; pfam02381 1002672002119 cell division protein FtsZ; Validated; Region: PRK09330 1002672002120 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1002672002121 nucleotide binding site [chemical binding]; other site 1002672002122 SulA interaction site; other site 1002672002123 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1002672002124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672002125 S-adenosylmethionine binding site [chemical binding]; other site 1002672002126 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1002672002127 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1002672002128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1002672002129 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1002672002130 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1002672002131 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1002672002132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1002672002133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1002672002134 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1002672002135 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1002672002136 Mg++ binding site [ion binding]; other site 1002672002137 putative catalytic motif [active] 1002672002138 putative substrate binding site [chemical binding]; other site 1002672002139 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1002672002140 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1002672002141 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1002672002142 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1002672002143 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1002672002144 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1002672002145 active site 1002672002146 homodimer interface [polypeptide binding]; other site 1002672002147 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1002672002148 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1002672002149 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1002672002150 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1002672002151 FAD binding domain; Region: FAD_binding_4; pfam01565 1002672002152 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1002672002153 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1002672002154 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1002672002155 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1002672002156 Cell division protein FtsQ; Region: FtsQ; pfam03799 1002672002157 Cell division protein FtsA; Region: FtsA; smart00842 1002672002158 Cell division protein FtsA; Region: FtsA; pfam14450 1002672002159 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1002672002160 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1002672002161 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1002672002162 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1002672002163 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1002672002164 nucleotide binding pocket [chemical binding]; other site 1002672002165 K-X-D-G motif; other site 1002672002166 catalytic site [active] 1002672002167 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1002672002168 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1002672002169 Dimer interface [polypeptide binding]; other site 1002672002170 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1002672002171 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1002672002172 active site 1002672002173 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1002672002174 Part of AAA domain; Region: AAA_19; pfam13245 1002672002175 Family description; Region: UvrD_C_2; pfam13538 1002672002176 AsmA family; Region: AsmA; pfam05170 1002672002177 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1002672002178 Class II fumarases; Region: Fumarase_classII; cd01362 1002672002179 active site 1002672002180 tetramer interface [polypeptide binding]; other site 1002672002181 short chain dehydrogenase; Provisional; Region: PRK07024 1002672002182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672002183 NAD(P) binding site [chemical binding]; other site 1002672002184 active site 1002672002185 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 1002672002186 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1002672002187 homodimer interface [polypeptide binding]; other site 1002672002188 substrate-cofactor binding pocket; other site 1002672002189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002190 catalytic residue [active] 1002672002191 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1002672002192 Sulphur transport; Region: Sulf_transp; pfam04143 1002672002193 Sulphur transport; Region: Sulf_transp; pfam04143 1002672002194 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1002672002195 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1002672002196 active site residue [active] 1002672002197 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1002672002198 active site residue [active] 1002672002199 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1002672002200 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1002672002201 dimer interface [polypeptide binding]; other site 1002672002202 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1002672002203 catalytic triad [active] 1002672002204 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1002672002205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1002672002206 putative DNA binding site [nucleotide binding]; other site 1002672002207 putative Zn2+ binding site [ion binding]; other site 1002672002208 AsnC family; Region: AsnC_trans_reg; pfam01037 1002672002209 LysE type translocator; Region: LysE; cl00565 1002672002210 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1002672002211 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1002672002212 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1002672002213 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 1002672002214 putative ligand binding site [chemical binding]; other site 1002672002215 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1002672002216 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1002672002217 TM-ABC transporter signature motif; other site 1002672002218 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1002672002219 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1002672002220 TM-ABC transporter signature motif; other site 1002672002221 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1002672002222 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1002672002223 Walker A/P-loop; other site 1002672002224 ATP binding site [chemical binding]; other site 1002672002225 Q-loop/lid; other site 1002672002226 ABC transporter signature motif; other site 1002672002227 Walker B; other site 1002672002228 D-loop; other site 1002672002229 H-loop/switch region; other site 1002672002230 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1002672002231 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1002672002232 Walker A/P-loop; other site 1002672002233 ATP binding site [chemical binding]; other site 1002672002234 Q-loop/lid; other site 1002672002235 ABC transporter signature motif; other site 1002672002236 Walker B; other site 1002672002237 D-loop; other site 1002672002238 H-loop/switch region; other site 1002672002239 AzlC protein; Region: AzlC; pfam03591 1002672002240 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1002672002241 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1002672002242 substrate binding pocket [chemical binding]; other site 1002672002243 active site 1002672002244 iron coordination sites [ion binding]; other site 1002672002245 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1002672002246 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1002672002247 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1002672002248 tetramer interface [polypeptide binding]; other site 1002672002249 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1002672002250 active site 1002672002251 Mg2+/Mn2+ binding site [ion binding]; other site 1002672002252 Bacterial transcriptional regulator; Region: IclR; pfam01614 1002672002253 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1002672002254 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1002672002255 dimerization interface [polypeptide binding]; other site 1002672002256 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1002672002257 NAD binding site [chemical binding]; other site 1002672002258 ligand binding site [chemical binding]; other site 1002672002259 catalytic site [active] 1002672002260 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1002672002261 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1002672002262 CoenzymeA binding site [chemical binding]; other site 1002672002263 subunit interaction site [polypeptide binding]; other site 1002672002264 PHB binding site; other site 1002672002265 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1002672002266 SelR domain; Region: SelR; pfam01641 1002672002267 tricarballylate dehydrogenase; Validated; Region: PRK08274 1002672002268 L-aspartate oxidase; Provisional; Region: PRK06175 1002672002269 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1002672002270 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1002672002271 Cupin domain; Region: Cupin_2; pfam07883 1002672002272 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1002672002273 tartrate dehydrogenase; Region: TTC; TIGR02089 1002672002274 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1002672002275 active site 1002672002276 iron coordination sites [ion binding]; other site 1002672002277 substrate binding pocket [chemical binding]; other site 1002672002278 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 1002672002279 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1002672002280 catalytic site [active] 1002672002281 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1002672002282 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1002672002283 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 1002672002284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1002672002285 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1002672002286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672002287 NAD(P) binding site [chemical binding]; other site 1002672002288 active site 1002672002289 aconitate hydratase; Validated; Region: PRK09277 1002672002290 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1002672002291 substrate binding site [chemical binding]; other site 1002672002292 ligand binding site [chemical binding]; other site 1002672002293 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1002672002294 substrate binding site [chemical binding]; other site 1002672002295 aconitate hydratase; Validated; Region: PRK09277 1002672002296 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1002672002297 substrate binding site [chemical binding]; other site 1002672002298 ligand binding site [chemical binding]; other site 1002672002299 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1002672002300 substrate binding site [chemical binding]; other site 1002672002301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1002672002302 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1002672002303 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1002672002304 active site 1002672002305 iron coordination sites [ion binding]; other site 1002672002306 substrate binding pocket [chemical binding]; other site 1002672002307 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1002672002308 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1002672002309 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1002672002310 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1002672002311 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1002672002312 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1002672002313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672002314 NAD(P) binding site [chemical binding]; other site 1002672002315 active site 1002672002316 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1002672002317 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1002672002318 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1002672002319 Pirin-related protein [General function prediction only]; Region: COG1741 1002672002320 Pirin; Region: Pirin; pfam02678 1002672002321 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1002672002322 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1002672002323 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1002672002324 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1002672002325 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1002672002326 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1002672002327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672002328 motif II; other site 1002672002329 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1002672002330 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 1002672002331 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1002672002332 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1002672002333 GTP cyclohydrolase I; Provisional; Region: PLN03044 1002672002334 active site 1002672002335 Zinc-finger domain; Region: zf-CHCC; cl01821 1002672002336 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1002672002337 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1002672002338 NADP binding site [chemical binding]; other site 1002672002339 dimer interface [polypeptide binding]; other site 1002672002340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1002672002341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1002672002342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1002672002343 dimerization interface [polypeptide binding]; other site 1002672002344 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1002672002345 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1002672002346 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1002672002347 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1002672002348 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1002672002349 active site 1002672002350 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1002672002351 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1002672002352 putative substrate binding region [chemical binding]; other site 1002672002353 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1002672002354 IHF dimer interface [polypeptide binding]; other site 1002672002355 IHF - DNA interface [nucleotide binding]; other site 1002672002356 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1002672002357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1002672002358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1002672002359 catalytic residue [active] 1002672002360 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1002672002361 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1002672002362 ligand binding site [chemical binding]; other site 1002672002363 NAD binding site [chemical binding]; other site 1002672002364 dimerization interface [polypeptide binding]; other site 1002672002365 catalytic site [active] 1002672002366 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1002672002367 putative L-serine binding site [chemical binding]; other site 1002672002368 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1002672002369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672002370 motif II; other site 1002672002371 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1002672002372 active site residue [active] 1002672002373 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1002672002374 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1002672002375 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1002672002376 NAD(P) binding site [chemical binding]; other site 1002672002377 catalytic residues [active] 1002672002378 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1002672002379 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1002672002380 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1002672002381 putative catalytic residue [active] 1002672002382 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1002672002383 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1002672002384 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1002672002385 active site 1002672002386 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 1002672002387 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1002672002388 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1002672002389 Ligand Binding Site [chemical binding]; other site 1002672002390 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1002672002391 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1002672002392 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1002672002393 ATP binding site [chemical binding]; other site 1002672002394 Mg++ binding site [ion binding]; other site 1002672002395 motif III; other site 1002672002396 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1002672002397 nucleotide binding region [chemical binding]; other site 1002672002398 ATP-binding site [chemical binding]; other site 1002672002399 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1002672002400 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1002672002401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672002402 S-adenosylmethionine binding site [chemical binding]; other site 1002672002403 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1002672002404 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1002672002405 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1002672002406 DinB superfamily; Region: DinB_2; pfam12867 1002672002407 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1002672002408 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1002672002409 tetramer interface [polypeptide binding]; other site 1002672002410 active site 1002672002411 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1002672002412 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1002672002413 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1002672002414 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1002672002415 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1002672002416 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1002672002417 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1002672002418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1002672002419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1002672002420 putative substrate translocation pore; other site 1002672002421 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1002672002422 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1002672002423 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1002672002424 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1002672002425 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1002672002426 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1002672002427 DctM-like transporters; Region: DctM; pfam06808 1002672002428 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1002672002429 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1002672002430 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1002672002431 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1002672002432 FMN binding site [chemical binding]; other site 1002672002433 active site 1002672002434 catalytic residues [active] 1002672002435 substrate binding site [chemical binding]; other site 1002672002436 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1002672002437 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1002672002438 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1002672002439 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1002672002440 putative acyltransferase; Provisional; Region: PRK05790 1002672002441 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1002672002442 dimer interface [polypeptide binding]; other site 1002672002443 active site 1002672002444 Predicted membrane protein [Function unknown]; Region: COG1238 1002672002445 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1002672002446 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1002672002447 acyl-activating enzyme (AAE) consensus motif; other site 1002672002448 putative AMP binding site [chemical binding]; other site 1002672002449 putative active site [active] 1002672002450 putative CoA binding site [chemical binding]; other site 1002672002451 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 1002672002452 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1002672002453 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1002672002454 metal binding site [ion binding]; metal-binding site 1002672002455 substrate binding pocket [chemical binding]; other site 1002672002456 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1002672002457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1002672002458 catalytic loop [active] 1002672002459 iron binding site [ion binding]; other site 1002672002460 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1002672002461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1002672002462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1002672002463 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1002672002464 Catalytic site [active] 1002672002465 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1002672002466 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1002672002467 active site 1002672002468 DNA binding site [nucleotide binding] 1002672002469 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1002672002470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672002471 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1002672002472 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1002672002473 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1002672002474 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1002672002475 C-terminal domain interface [polypeptide binding]; other site 1002672002476 GSH binding site (G-site) [chemical binding]; other site 1002672002477 dimer interface [polypeptide binding]; other site 1002672002478 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1002672002479 N-terminal domain interface [polypeptide binding]; other site 1002672002480 dimer interface [polypeptide binding]; other site 1002672002481 substrate binding pocket (H-site) [chemical binding]; other site 1002672002482 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1002672002483 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1002672002484 putative catalytic residue [active] 1002672002485 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1002672002486 recombinase A; Provisional; Region: recA; PRK09354 1002672002487 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1002672002488 hexamer interface [polypeptide binding]; other site 1002672002489 Walker A motif; other site 1002672002490 ATP binding site [chemical binding]; other site 1002672002491 Walker B motif; other site 1002672002492 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1002672002493 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1002672002494 motif 1; other site 1002672002495 active site 1002672002496 motif 2; other site 1002672002497 motif 3; other site 1002672002498 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1002672002499 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1002672002500 isocitrate dehydrogenase; Validated; Region: PRK08299 1002672002501 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1002672002502 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1002672002503 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1002672002504 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1002672002505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672002506 S-adenosylmethionine binding site [chemical binding]; other site 1002672002507 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1002672002508 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672002509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1002672002510 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1002672002511 active site 1002672002512 TPR repeat; Region: TPR_11; pfam13414 1002672002513 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1002672002514 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1002672002515 AMP/PPi binding site [chemical binding]; other site 1002672002516 candidate oxyanion hole; other site 1002672002517 catalytic triad [active] 1002672002518 potential glutamine specificity residues [chemical binding]; other site 1002672002519 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1002672002520 Ligand Binding Site [chemical binding]; other site 1002672002521 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1002672002522 ATP Binding subdomain [chemical binding]; other site 1002672002523 Dimerization subdomain; other site 1002672002524 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1002672002525 oligomerization interface [polypeptide binding]; other site 1002672002526 active site 1002672002527 metal binding site [ion binding]; metal-binding site 1002672002528 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1002672002529 Trp docking motif [polypeptide binding]; other site 1002672002530 active site 1002672002531 PQQ-like domain; Region: PQQ_2; pfam13360 1002672002532 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1002672002533 G1 box; other site 1002672002534 GTP/Mg2+ binding site [chemical binding]; other site 1002672002535 G2 box; other site 1002672002536 Switch I region; other site 1002672002537 G3 box; other site 1002672002538 Switch II region; other site 1002672002539 G4 box; other site 1002672002540 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1002672002541 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1002672002542 active site 1002672002543 tetramer interface [polypeptide binding]; other site 1002672002544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1002672002545 active site 1002672002546 Colicin V production protein; Region: Colicin_V; cl00567 1002672002547 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1002672002548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1002672002549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1002672002550 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1002672002551 catalytic residue [active] 1002672002552 replicative DNA helicase; Provisional; Region: PRK09165 1002672002553 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1002672002554 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1002672002555 Walker A motif; other site 1002672002556 ATP binding site [chemical binding]; other site 1002672002557 Walker B motif; other site 1002672002558 DNA binding loops [nucleotide binding] 1002672002559 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1002672002560 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1002672002561 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1002672002562 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1002672002563 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1002672002564 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1002672002565 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1002672002566 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1002672002567 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1002672002568 NAD(P) binding site [chemical binding]; other site 1002672002569 homotetramer interface [polypeptide binding]; other site 1002672002570 homodimer interface [polypeptide binding]; other site 1002672002571 active site 1002672002572 acyl carrier protein; Provisional; Region: acpP; PRK00982 1002672002573 Guanylate kinase; Region: Guanylate_kin; pfam00625 1002672002574 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1002672002575 catalytic site [active] 1002672002576 G-X2-G-X-G-K; other site 1002672002577 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1002672002578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672002579 S-adenosylmethionine binding site [chemical binding]; other site 1002672002580 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1002672002581 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1002672002582 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1002672002583 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1002672002584 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1002672002585 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1002672002586 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1002672002587 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1002672002588 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1002672002589 interface (dimer of trimers) [polypeptide binding]; other site 1002672002590 Substrate-binding/catalytic site; other site 1002672002591 Zn-binding sites [ion binding]; other site 1002672002592 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1002672002593 active site 1002672002594 multimer interface [polypeptide binding]; other site 1002672002595 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1002672002596 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1002672002597 active site 1002672002598 substrate binding site [chemical binding]; other site 1002672002599 cosubstrate binding site; other site 1002672002600 catalytic site [active] 1002672002601 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1002672002602 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1002672002603 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1002672002604 dimerization interface [polypeptide binding]; other site 1002672002605 putative ATP binding site [chemical binding]; other site 1002672002606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1002672002607 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1002672002608 catalytic site [active] 1002672002609 putative active site [active] 1002672002610 putative substrate binding site [chemical binding]; other site 1002672002611 HRDC domain; Region: HRDC; cl02578 1002672002612 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1002672002613 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1002672002614 anticodon binding site; other site 1002672002615 Dimer interface [polypeptide binding]; other site 1002672002616 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1002672002617 homodimer interface [polypeptide binding]; other site 1002672002618 motif 1; other site 1002672002619 active site 1002672002620 motif 2; other site 1002672002621 GAD domain; Region: GAD; pfam02938 1002672002622 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1002672002623 active site 1002672002624 motif 3; other site 1002672002625 TSCPD domain; Region: TSCPD; pfam12637 1002672002626 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 1002672002627 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 1002672002628 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1002672002629 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1002672002630 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1002672002631 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1002672002632 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1002672002633 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1002672002634 carboxyltransferase (CT) interaction site; other site 1002672002635 biotinylation site [posttranslational modification]; other site 1002672002636 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1002672002637 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1002672002638 trimer interface [polypeptide binding]; other site 1002672002639 active site 1002672002640 dimer interface [polypeptide binding]; other site 1002672002641 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1002672002642 thiS-thiF/thiG interaction site; other site 1002672002643 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1002672002644 ThiS interaction site; other site 1002672002645 putative active site [active] 1002672002646 tetramer interface [polypeptide binding]; other site 1002672002647 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1002672002648 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1002672002649 FOG: CBS domain [General function prediction only]; Region: COG0517 1002672002650 PIF1-like helicase; Region: PIF1; pfam05970 1002672002651 AAA domain; Region: AAA_30; pfam13604 1002672002652 Family description; Region: UvrD_C_2; pfam13538 1002672002653 HD domain; Region: HD_4; pfam13328 1002672002654 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 1002672002655 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1002672002656 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1002672002657 classical (c) SDRs; Region: SDR_c; cd05233 1002672002658 NAD(P) binding site [chemical binding]; other site 1002672002659 active site 1002672002660 Alternative oxidase; Region: AOX; pfam01786 1002672002661 dinuclear metal binding motif [ion binding]; other site 1002672002662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1002672002663 ATP binding site [chemical binding]; other site 1002672002664 putative Mg++ binding site [ion binding]; other site 1002672002665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1002672002666 nucleotide binding region [chemical binding]; other site 1002672002667 ATP-binding site [chemical binding]; other site 1002672002668 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1002672002669 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1002672002670 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1002672002671 lipoyl attachment site [posttranslational modification]; other site 1002672002672 glycine dehydrogenase; Provisional; Region: PRK05367 1002672002673 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1002672002674 tetramer interface [polypeptide binding]; other site 1002672002675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002676 catalytic residue [active] 1002672002677 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1002672002678 tetramer interface [polypeptide binding]; other site 1002672002679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002680 catalytic residue [active] 1002672002681 TspO/MBR family; Region: TspO_MBR; pfam03073 1002672002682 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1002672002683 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1002672002684 substrate binding pocket [chemical binding]; other site 1002672002685 chain length determination region; other site 1002672002686 substrate-Mg2+ binding site; other site 1002672002687 catalytic residues [active] 1002672002688 aspartate-rich region 1; other site 1002672002689 active site lid residues [active] 1002672002690 aspartate-rich region 2; other site 1002672002691 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1002672002692 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1002672002693 tandem repeat interface [polypeptide binding]; other site 1002672002694 oligomer interface [polypeptide binding]; other site 1002672002695 active site residues [active] 1002672002696 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1002672002697 dimer interface [polypeptide binding]; other site 1002672002698 motif 1; other site 1002672002699 active site 1002672002700 motif 2; other site 1002672002701 motif 3; other site 1002672002702 potential frameshift: common BLAST hit: gi|71083322|ref|YP_266041.1| glycyl-tRNA synthetase subunit beta 1002672002703 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 1002672002704 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1002672002705 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1002672002706 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1002672002707 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1002672002708 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1002672002709 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1002672002710 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1002672002711 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1002672002712 dimerization interface [polypeptide binding]; other site 1002672002713 active site 1002672002714 quinolinate synthetase; Provisional; Region: PRK09375 1002672002715 aspartate aminotransferase; Provisional; Region: PRK05764 1002672002716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1002672002717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002718 homodimer interface [polypeptide binding]; other site 1002672002719 catalytic residue [active] 1002672002720 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1002672002721 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1002672002722 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 1002672002723 DctM-like transporters; Region: DctM; pfam06808 1002672002724 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 1002672002725 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1002672002726 protein binding site [polypeptide binding]; other site 1002672002727 Fe-S metabolism associated domain; Region: SufE; cl00951 1002672002728 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1002672002729 trimerization site [polypeptide binding]; other site 1002672002730 active site 1002672002731 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672002732 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1002672002733 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1002672002734 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1002672002735 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1002672002736 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1002672002737 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1002672002738 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1002672002739 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1002672002740 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1002672002741 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1002672002742 putative dimer interface [polypeptide binding]; other site 1002672002743 [2Fe-2S] cluster binding site [ion binding]; other site 1002672002744 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1002672002745 SLBB domain; Region: SLBB; pfam10531 1002672002746 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1002672002747 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1002672002748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1002672002749 catalytic loop [active] 1002672002750 iron binding site [ion binding]; other site 1002672002751 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1002672002752 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1002672002753 molybdopterin cofactor binding site; other site 1002672002754 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1002672002755 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1002672002756 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1002672002757 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1002672002758 4Fe-4S binding domain; Region: Fer4; pfam00037 1002672002759 4Fe-4S binding domain; Region: Fer4; pfam00037 1002672002760 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 1002672002761 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1002672002762 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1002672002763 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1002672002764 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 1002672002765 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1002672002766 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1002672002767 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197 1002672002768 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1002672002769 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1002672002770 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1002672002771 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1002672002772 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1002672002773 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1002672002774 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1002672002775 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1002672002776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1002672002777 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1002672002778 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 1002672002779 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1002672002780 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1002672002781 dimer interface [polypeptide binding]; other site 1002672002782 motif 1; other site 1002672002783 active site 1002672002784 motif 2; other site 1002672002785 motif 3; other site 1002672002786 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1002672002787 anticodon binding site; other site 1002672002788 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1002672002789 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1002672002790 FtsX-like permease family; Region: FtsX; pfam02687 1002672002791 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1002672002792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1002672002793 Walker A/P-loop; other site 1002672002794 ATP binding site [chemical binding]; other site 1002672002795 Q-loop/lid; other site 1002672002796 ABC transporter signature motif; other site 1002672002797 Walker B; other site 1002672002798 D-loop; other site 1002672002799 H-loop/switch region; other site 1002672002800 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1002672002801 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1002672002802 putative active site [active] 1002672002803 putative PHP Thumb interface [polypeptide binding]; other site 1002672002804 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1002672002805 generic binding surface I; other site 1002672002806 generic binding surface II; other site 1002672002807 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1002672002808 rRNA interaction site [nucleotide binding]; other site 1002672002809 S8 interaction site; other site 1002672002810 putative laminin-1 binding site; other site 1002672002811 UBA/TS-N domain; Region: UBA; pfam00627 1002672002812 elongation factor Ts; Provisional; Region: tsf; PRK09377 1002672002813 Elongation factor TS; Region: EF_TS; pfam00889 1002672002814 Elongation factor TS; Region: EF_TS; pfam00889 1002672002815 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1002672002816 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1002672002817 hinge region; other site 1002672002818 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1002672002819 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1002672002820 catalytic residue [active] 1002672002821 putative FPP diphosphate binding site; other site 1002672002822 putative FPP binding hydrophobic cleft; other site 1002672002823 dimer interface [polypeptide binding]; other site 1002672002824 putative IPP diphosphate binding site; other site 1002672002825 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1002672002826 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1002672002827 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1002672002828 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1002672002829 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1002672002830 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1002672002831 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1002672002832 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1002672002833 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1002672002834 Surface antigen; Region: Bac_surface_Ag; pfam01103 1002672002835 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1002672002836 trimer interface [polypeptide binding]; other site 1002672002837 active site 1002672002838 UDP-GlcNAc binding site [chemical binding]; other site 1002672002839 lipid binding site [chemical binding]; lipid-binding site 1002672002840 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1002672002841 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1002672002842 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1002672002843 active site 1002672002844 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1002672002845 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1002672002846 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1002672002847 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1002672002848 dimer interface [polypeptide binding]; other site 1002672002849 active site 1002672002850 citrylCoA binding site [chemical binding]; other site 1002672002851 NADH binding [chemical binding]; other site 1002672002852 cationic pore residues; other site 1002672002853 oxalacetate/citrate binding site [chemical binding]; other site 1002672002854 coenzyme A binding site [chemical binding]; other site 1002672002855 catalytic triad [active] 1002672002856 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1002672002857 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672002858 active site 1002672002859 HIGH motif; other site 1002672002860 nucleotide binding site [chemical binding]; other site 1002672002861 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1002672002862 active site 1002672002863 KMSKS motif; other site 1002672002864 LexA repressor; Validated; Region: PRK00215 1002672002865 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1002672002866 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1002672002867 Catalytic site [active] 1002672002868 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672002869 phosphate binding site [ion binding]; other site 1002672002870 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1002672002871 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1002672002872 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1002672002873 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1002672002874 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1002672002875 catalytic triad [active] 1002672002876 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1002672002877 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1002672002878 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1002672002879 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1002672002880 SurA N-terminal domain; Region: SurA_N_3; cl07813 1002672002881 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1002672002882 substrate binding site [chemical binding]; other site 1002672002883 catalytic triad [active] 1002672002884 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1002672002885 CTP synthetase; Validated; Region: pyrG; PRK05380 1002672002886 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1002672002887 Catalytic site [active] 1002672002888 active site 1002672002889 UTP binding site [chemical binding]; other site 1002672002890 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1002672002891 active site 1002672002892 putative oxyanion hole; other site 1002672002893 catalytic triad [active] 1002672002894 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1002672002895 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1002672002896 enolase; Provisional; Region: eno; PRK00077 1002672002897 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1002672002898 dimer interface [polypeptide binding]; other site 1002672002899 metal binding site [ion binding]; metal-binding site 1002672002900 substrate binding pocket [chemical binding]; other site 1002672002901 lipoyl synthase; Provisional; Region: PRK05481 1002672002902 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1002672002903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1002672002904 FeS/SAM binding site; other site 1002672002905 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1002672002906 putative coenzyme Q binding site [chemical binding]; other site 1002672002907 Competence-damaged protein; Region: CinA; pfam02464 1002672002908 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1002672002909 tetramer interfaces [polypeptide binding]; other site 1002672002910 binuclear metal-binding site [ion binding]; other site 1002672002911 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1002672002912 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1002672002913 substrate binding site; other site 1002672002914 dimer interface; other site 1002672002915 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1002672002916 homotrimer interaction site [polypeptide binding]; other site 1002672002917 zinc binding site [ion binding]; other site 1002672002918 CDP-binding sites; other site 1002672002919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1002672002920 dimerization interface [polypeptide binding]; other site 1002672002921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1002672002922 dimer interface [polypeptide binding]; other site 1002672002923 phosphorylation site [posttranslational modification] 1002672002924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672002925 ATP binding site [chemical binding]; other site 1002672002926 Mg2+ binding site [ion binding]; other site 1002672002927 G-X-G motif; other site 1002672002928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1002672002929 active site 1002672002930 dimerization interface [polypeptide binding]; other site 1002672002931 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1002672002932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672002933 Walker A motif; other site 1002672002934 ATP binding site [chemical binding]; other site 1002672002935 Walker B motif; other site 1002672002936 arginine finger; other site 1002672002937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1002672002938 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1002672002939 TrkA-N domain; Region: TrkA_N; pfam02254 1002672002940 TrkA-N domain; Region: TrkA_N; pfam02254 1002672002941 TrkA-C domain; Region: TrkA_C; pfam02080 1002672002942 Cation transport protein; Region: TrkH; cl17365 1002672002943 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1002672002944 GIY-YIG motif/motif A; other site 1002672002945 putative active site [active] 1002672002946 putative metal binding site [ion binding]; other site 1002672002947 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1002672002948 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1002672002949 substrate binding pocket [chemical binding]; other site 1002672002950 membrane-bound complex binding site; other site 1002672002951 hinge residues; other site 1002672002952 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1002672002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672002954 conserved gate region; other site 1002672002955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672002956 dimer interface [polypeptide binding]; other site 1002672002957 ABC-ATPase subunit interface; other site 1002672002958 putative PBP binding loops; other site 1002672002959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672002960 dimer interface [polypeptide binding]; other site 1002672002961 conserved gate region; other site 1002672002962 ABC-ATPase subunit interface; other site 1002672002963 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1002672002964 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1002672002965 Walker A/P-loop; other site 1002672002966 ATP binding site [chemical binding]; other site 1002672002967 Q-loop/lid; other site 1002672002968 ABC transporter signature motif; other site 1002672002969 Walker B; other site 1002672002970 D-loop; other site 1002672002971 H-loop/switch region; other site 1002672002972 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1002672002973 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1002672002974 dimer interface [polypeptide binding]; other site 1002672002975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672002976 catalytic residue [active] 1002672002977 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1002672002978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672002979 S-adenosylmethionine binding site [chemical binding]; other site 1002672002980 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 1002672002981 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1002672002982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1002672002983 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1002672002984 DNA photolyase; Region: DNA_photolyase; pfam00875 1002672002985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1002672002986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1002672002987 non-specific DNA binding site [nucleotide binding]; other site 1002672002988 salt bridge; other site 1002672002989 sequence-specific DNA binding site [nucleotide binding]; other site 1002672002990 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1002672002991 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1002672002992 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1002672002993 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672002994 active site 1002672002995 HIGH motif; other site 1002672002996 nucleotide binding site [chemical binding]; other site 1002672002997 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1002672002998 active site 1002672002999 KMSKS motif; other site 1002672003000 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1002672003001 tRNA binding surface [nucleotide binding]; other site 1002672003002 anticodon binding site; other site 1002672003003 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1002672003004 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1002672003005 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1002672003006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672003007 active site 1002672003008 Cupin domain; Region: Cupin_2; cl17218 1002672003009 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1002672003010 active site 1002672003011 DNA binding site [nucleotide binding] 1002672003012 putative catalytic site [active] 1002672003013 metal binding site A [ion binding]; metal-binding site 1002672003014 putative phosphate binding site [ion binding]; other site 1002672003015 putative AP binding site [nucleotide binding]; other site 1002672003016 putative metal binding site B [ion binding]; other site 1002672003017 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1002672003018 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1002672003019 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1002672003020 Zn2+ binding site [ion binding]; other site 1002672003021 Mg2+ binding site [ion binding]; other site 1002672003022 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1002672003023 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1002672003024 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1002672003025 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1002672003026 active site 1002672003027 HIGH motif; other site 1002672003028 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672003029 KMSK motif region; other site 1002672003030 tRNA binding surface [nucleotide binding]; other site 1002672003031 DALR anticodon binding domain; Region: DALR_1; smart00836 1002672003032 anticodon binding site; other site 1002672003033 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1002672003034 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1002672003035 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1002672003036 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1002672003037 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1002672003038 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1002672003039 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1002672003040 seryl-tRNA synthetase; Provisional; Region: PRK05431 1002672003041 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1002672003042 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1002672003043 dimer interface [polypeptide binding]; other site 1002672003044 active site 1002672003045 motif 1; other site 1002672003046 motif 2; other site 1002672003047 motif 3; other site 1002672003048 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1002672003049 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1002672003050 acyl-activating enzyme (AAE) consensus motif; other site 1002672003051 AMP binding site [chemical binding]; other site 1002672003052 active site 1002672003053 CoA binding site [chemical binding]; other site 1002672003054 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1002672003055 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1002672003056 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1002672003057 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1002672003058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1002672003059 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1002672003060 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1002672003061 thymidylate kinase; Validated; Region: tmk; PRK00698 1002672003062 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1002672003063 TMP-binding site; other site 1002672003064 ATP-binding site [chemical binding]; other site 1002672003065 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1002672003066 IHF - DNA interface [nucleotide binding]; other site 1002672003067 IHF dimer interface [polypeptide binding]; other site 1002672003068 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1002672003069 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1002672003070 DNA binding residues [nucleotide binding] 1002672003071 Chorismate mutase type II; Region: CM_2; smart00830 1002672003072 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1002672003073 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1002672003074 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1002672003075 23S rRNA interface [nucleotide binding]; other site 1002672003076 L3 interface [polypeptide binding]; other site 1002672003077 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1002672003078 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1002672003079 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1002672003080 homoserine dehydrogenase; Provisional; Region: PRK06349 1002672003081 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1002672003082 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1002672003083 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1002672003084 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1002672003085 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1002672003086 putative active site [active] 1002672003087 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1002672003088 DHH family; Region: DHH; pfam01368 1002672003089 DHHA1 domain; Region: DHHA1; pfam02272 1002672003090 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1002672003091 catalytic residues [active] 1002672003092 dimer interface [polypeptide binding]; other site 1002672003093 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1002672003094 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1002672003095 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1002672003096 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1002672003097 generic binding surface II; other site 1002672003098 ssDNA binding site; other site 1002672003099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1002672003100 ATP binding site [chemical binding]; other site 1002672003101 putative Mg++ binding site [ion binding]; other site 1002672003102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1002672003103 nucleotide binding region [chemical binding]; other site 1002672003104 ATP-binding site [chemical binding]; other site 1002672003105 Preprotein translocase subunit; Region: YajC; pfam02699 1002672003106 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1002672003107 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1002672003108 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1002672003109 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1002672003110 Protein export membrane protein; Region: SecD_SecF; pfam02355 1002672003111 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1002672003112 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1002672003113 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1002672003114 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1002672003115 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1002672003116 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1002672003117 dimer interface [polypeptide binding]; other site 1002672003118 ssDNA binding site [nucleotide binding]; other site 1002672003119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1002672003120 DNA gyrase subunit A; Validated; Region: PRK05560 1002672003121 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1002672003122 CAP-like domain; other site 1002672003123 active site 1002672003124 primary dimer interface [polypeptide binding]; other site 1002672003125 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1002672003126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1002672003127 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1002672003128 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1002672003129 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1002672003130 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1002672003131 active site 1002672003132 (T/H)XGH motif; other site 1002672003133 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1002672003134 active site 1002672003135 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1002672003136 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1002672003137 Peptidase family M48; Region: Peptidase_M48; pfam01435 1002672003138 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1002672003139 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1002672003140 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1002672003141 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1002672003142 DNA binding site [nucleotide binding] 1002672003143 active site 1002672003144 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1002672003145 DNA binding site [nucleotide binding] 1002672003146 dimer interface [polypeptide binding]; other site 1002672003147 active site 1002672003148 Int/Topo IB signature motif; other site 1002672003149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1002672003150 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1002672003151 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1002672003152 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1002672003153 active site 1002672003154 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 1002672003155 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1002672003156 HIGH motif; other site 1002672003157 active site 1002672003158 KMSKS motif; other site 1002672003159 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1002672003160 tRNA binding surface [nucleotide binding]; other site 1002672003161 anticodon binding site; other site 1002672003162 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1002672003163 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1002672003164 DNA polymerase III subunit delta'; Validated; Region: PRK07132 1002672003165 putative phosphate acyltransferase; Provisional; Region: PRK05331 1002672003166 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1002672003167 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1002672003168 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1002672003169 NusB family; Region: NusB; pfam01029 1002672003170 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1002672003171 homopentamer interface [polypeptide binding]; other site 1002672003172 active site 1002672003173 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1002672003174 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1002672003175 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1002672003176 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1002672003177 Lumazine binding domain; Region: Lum_binding; pfam00677 1002672003178 Lumazine binding domain; Region: Lum_binding; pfam00677 1002672003179 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1002672003180 catalytic motif [active] 1002672003181 Zn binding site [ion binding]; other site 1002672003182 RibD C-terminal domain; Region: RibD_C; cl17279 1002672003183 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1002672003184 ATP cone domain; Region: ATP-cone; pfam03477 1002672003185 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1002672003186 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1002672003187 dimer interface [polypeptide binding]; other site 1002672003188 active site 1002672003189 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1002672003190 folate binding site [chemical binding]; other site 1002672003191 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1002672003192 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1002672003193 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1002672003194 dimer interface [polypeptide binding]; other site 1002672003195 active site 1002672003196 Schiff base residues; other site 1002672003197 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1002672003198 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1002672003199 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1002672003200 CAP-like domain; other site 1002672003201 active site 1002672003202 primary dimer interface [polypeptide binding]; other site 1002672003203 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1002672003204 Recombination protein O N terminal; Region: RecO_N; pfam11967 1002672003205 GTPase Era; Reviewed; Region: era; PRK00089 1002672003206 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1002672003207 G1 box; other site 1002672003208 GTP/Mg2+ binding site [chemical binding]; other site 1002672003209 Switch I region; other site 1002672003210 G2 box; other site 1002672003211 Switch II region; other site 1002672003212 G3 box; other site 1002672003213 G4 box; other site 1002672003214 G5 box; other site 1002672003215 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1002672003216 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1002672003217 dimerization interface [polypeptide binding]; other site 1002672003218 active site 1002672003219 metal binding site [ion binding]; metal-binding site 1002672003220 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1002672003221 dsRNA binding site [nucleotide binding]; other site 1002672003222 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1002672003223 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1002672003224 Catalytic site [active] 1002672003225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1002672003226 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1002672003227 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 1002672003228 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 1002672003229 active site 1002672003230 catalytic residues [active] 1002672003231 active site lid [active] 1002672003232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1002672003233 active site 1002672003234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1002672003235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1002672003236 Zn2+ binding site [ion binding]; other site 1002672003237 Mg2+ binding site [ion binding]; other site 1002672003238 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1002672003239 synthetase active site [active] 1002672003240 NTP binding site [chemical binding]; other site 1002672003241 metal binding site [ion binding]; metal-binding site 1002672003242 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1002672003243 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1002672003244 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1002672003245 catalytic center binding site [active] 1002672003246 ATP binding site [chemical binding]; other site 1002672003247 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1002672003248 SmpB-tmRNA interface; other site 1002672003249 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1002672003250 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1002672003251 dimer interface [polypeptide binding]; other site 1002672003252 active site 1002672003253 catalytic residue [active] 1002672003254 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1002672003255 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1002672003256 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1002672003257 catalytic residue [active] 1002672003258 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 1002672003259 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1002672003260 catalytic triad [active] 1002672003261 dimer interface [polypeptide binding]; other site 1002672003262 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1002672003263 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1002672003264 active site residue [active] 1002672003265 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1002672003266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1002672003267 S-adenosylmethionine binding site [chemical binding]; other site 1002672003268 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1002672003269 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1002672003270 GatB domain; Region: GatB_Yqey; smart00845 1002672003271 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1002672003272 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1002672003273 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1002672003274 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1002672003275 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1002672003276 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1002672003277 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1002672003278 dihydroorotase; Validated; Region: PRK09059 1002672003279 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1002672003280 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1002672003281 active site 1002672003282 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1002672003283 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1002672003284 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1002672003285 active site 1002672003286 interdomain interaction site; other site 1002672003287 putative metal-binding site [ion binding]; other site 1002672003288 nucleotide binding site [chemical binding]; other site 1002672003289 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1002672003290 domain I; other site 1002672003291 DNA binding groove [nucleotide binding] 1002672003292 phosphate binding site [ion binding]; other site 1002672003293 domain II; other site 1002672003294 domain III; other site 1002672003295 nucleotide binding site [chemical binding]; other site 1002672003296 catalytic site [active] 1002672003297 domain IV; other site 1002672003298 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1002672003299 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1002672003300 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1002672003301 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1002672003302 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1002672003303 homotrimer interaction site [polypeptide binding]; other site 1002672003304 putative active site [active] 1002672003305 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1002672003306 Clp amino terminal domain; Region: Clp_N; pfam02861 1002672003307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672003308 Walker A motif; other site 1002672003309 ATP binding site [chemical binding]; other site 1002672003310 Walker B motif; other site 1002672003311 arginine finger; other site 1002672003312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672003313 Walker A motif; other site 1002672003314 ATP binding site [chemical binding]; other site 1002672003315 Walker B motif; other site 1002672003316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1002672003317 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1002672003318 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1002672003319 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1002672003320 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1002672003321 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1002672003322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672003323 active site 1002672003324 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672003325 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1002672003326 active site 1002672003327 nucleotide binding site [chemical binding]; other site 1002672003328 HIGH motif; other site 1002672003329 KMSKS motif; other site 1002672003330 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1002672003331 MgtE intracellular N domain; Region: MgtE_N; smart00924 1002672003332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1002672003333 Divalent cation transporter; Region: MgtE; pfam01769 1002672003334 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1002672003335 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1002672003336 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1002672003337 active site 1002672003338 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1002672003339 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1002672003340 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1002672003341 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1002672003342 alphaNTD - beta interaction site [polypeptide binding]; other site 1002672003343 alphaNTD homodimer interface [polypeptide binding]; other site 1002672003344 alphaNTD - beta' interaction site [polypeptide binding]; other site 1002672003345 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1002672003346 30S ribosomal protein S11; Validated; Region: PRK05309 1002672003347 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1002672003348 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1002672003349 adenylate kinase; Reviewed; Region: adk; PRK00279 1002672003350 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1002672003351 AMP-binding site [chemical binding]; other site 1002672003352 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1002672003353 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1002672003354 SecY translocase; Region: SecY; pfam00344 1002672003355 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1002672003356 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1002672003357 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1002672003358 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1002672003359 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1002672003360 23S rRNA interface [nucleotide binding]; other site 1002672003361 L21e interface [polypeptide binding]; other site 1002672003362 5S rRNA interface [nucleotide binding]; other site 1002672003363 L27 interface [polypeptide binding]; other site 1002672003364 L5 interface [polypeptide binding]; other site 1002672003365 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1002672003366 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1002672003367 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1002672003368 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1002672003369 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1002672003370 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1002672003371 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1002672003372 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1002672003373 RNA binding site [nucleotide binding]; other site 1002672003374 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1002672003375 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1002672003376 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1002672003377 23S rRNA interface [nucleotide binding]; other site 1002672003378 putative translocon interaction site; other site 1002672003379 signal recognition particle (SRP54) interaction site; other site 1002672003380 L23 interface [polypeptide binding]; other site 1002672003381 trigger factor interaction site; other site 1002672003382 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1002672003383 23S rRNA interface [nucleotide binding]; other site 1002672003384 5S rRNA interface [nucleotide binding]; other site 1002672003385 putative antibiotic binding site [chemical binding]; other site 1002672003386 L25 interface [polypeptide binding]; other site 1002672003387 L27 interface [polypeptide binding]; other site 1002672003388 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1002672003389 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1002672003390 G-X-X-G motif; other site 1002672003391 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1002672003392 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1002672003393 putative translocon binding site; other site 1002672003394 protein-rRNA interface [nucleotide binding]; other site 1002672003395 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1002672003396 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1002672003397 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1002672003398 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1002672003399 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1002672003400 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1002672003401 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1002672003402 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1002672003403 elongation factor G; Reviewed; Region: PRK00007 1002672003404 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1002672003405 G1 box; other site 1002672003406 putative GEF interaction site [polypeptide binding]; other site 1002672003407 GTP/Mg2+ binding site [chemical binding]; other site 1002672003408 Switch I region; other site 1002672003409 G2 box; other site 1002672003410 G3 box; other site 1002672003411 Switch II region; other site 1002672003412 G4 box; other site 1002672003413 G5 box; other site 1002672003414 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1002672003415 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1002672003416 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1002672003417 30S ribosomal protein S7; Validated; Region: PRK05302 1002672003418 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1002672003419 16S rRNA interaction site [nucleotide binding]; other site 1002672003420 streptomycin interaction site [chemical binding]; other site 1002672003421 23S rRNA interaction site [nucleotide binding]; other site 1002672003422 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1002672003423 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1002672003424 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1002672003425 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1002672003426 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1002672003427 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1002672003428 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1002672003429 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1002672003430 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1002672003431 DNA binding site [nucleotide binding] 1002672003432 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1002672003433 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1002672003434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1002672003435 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1002672003436 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1002672003437 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1002672003438 RPB3 interaction site [polypeptide binding]; other site 1002672003439 RPB12 interaction site [polypeptide binding]; other site 1002672003440 RPB1 interaction site [polypeptide binding]; other site 1002672003441 RPB11 interaction site [polypeptide binding]; other site 1002672003442 RPB10 interaction site [polypeptide binding]; other site 1002672003443 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1002672003444 core dimer interface [polypeptide binding]; other site 1002672003445 peripheral dimer interface [polypeptide binding]; other site 1002672003446 L10 interface [polypeptide binding]; other site 1002672003447 L11 interface [polypeptide binding]; other site 1002672003448 putative EF-Tu interaction site [polypeptide binding]; other site 1002672003449 putative EF-G interaction site [polypeptide binding]; other site 1002672003450 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1002672003451 23S rRNA interface [nucleotide binding]; other site 1002672003452 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1002672003453 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1002672003454 mRNA/rRNA interface [nucleotide binding]; other site 1002672003455 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1002672003456 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1002672003457 23S rRNA interface [nucleotide binding]; other site 1002672003458 L7/L12 interface [polypeptide binding]; other site 1002672003459 putative thiostrepton binding site; other site 1002672003460 L25 interface [polypeptide binding]; other site 1002672003461 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1002672003462 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1002672003463 putative homodimer interface [polypeptide binding]; other site 1002672003464 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1002672003465 heterodimer interface [polypeptide binding]; other site 1002672003466 homodimer interface [polypeptide binding]; other site 1002672003467 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1002672003468 elongation factor Tu; Reviewed; Region: PRK00049 1002672003469 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1002672003470 G1 box; other site 1002672003471 GEF interaction site [polypeptide binding]; other site 1002672003472 GTP/Mg2+ binding site [chemical binding]; other site 1002672003473 Switch I region; other site 1002672003474 G2 box; other site 1002672003475 G3 box; other site 1002672003476 Switch II region; other site 1002672003477 G4 box; other site 1002672003478 G5 box; other site 1002672003479 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1002672003480 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1002672003481 Antibiotic Binding Site [chemical binding]; other site 1002672003482 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1002672003483 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1002672003484 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1002672003485 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 1002672003486 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1002672003487 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1002672003488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672003489 Walker A motif; other site 1002672003490 ATP binding site [chemical binding]; other site 1002672003491 Walker B motif; other site 1002672003492 arginine finger; other site 1002672003493 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1002672003494 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1002672003495 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1002672003496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672003497 Walker A motif; other site 1002672003498 ATP binding site [chemical binding]; other site 1002672003499 Walker B motif; other site 1002672003500 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1002672003501 Clp protease; Region: CLP_protease; pfam00574 1002672003502 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1002672003503 oligomer interface [polypeptide binding]; other site 1002672003504 active site residues [active] 1002672003505 trigger factor; Provisional; Region: tig; PRK01490 1002672003506 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1002672003507 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1002672003508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1002672003509 active site 1002672003510 glutamine synthetase; Provisional; Region: glnA; PRK09469 1002672003511 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1002672003512 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1002672003513 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1002672003514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1002672003515 ATP binding site [chemical binding]; other site 1002672003516 Mg2+ binding site [ion binding]; other site 1002672003517 G-X-G motif; other site 1002672003518 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1002672003519 anchoring element; other site 1002672003520 dimer interface [polypeptide binding]; other site 1002672003521 ATP binding site [chemical binding]; other site 1002672003522 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1002672003523 active site 1002672003524 metal binding site [ion binding]; metal-binding site 1002672003525 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1002672003526 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1002672003527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1002672003528 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1002672003529 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1002672003530 putative MPT binding site; other site 1002672003531 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1002672003532 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1002672003533 active site 1002672003534 adenylosuccinate lyase; Provisional; Region: PRK07492 1002672003535 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1002672003536 tetramer interface [polypeptide binding]; other site 1002672003537 active site 1002672003538 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1002672003539 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1002672003540 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1002672003541 ATP binding site [chemical binding]; other site 1002672003542 active site 1002672003543 substrate binding site [chemical binding]; other site 1002672003544 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1002672003545 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1002672003546 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1002672003547 putative active site [active] 1002672003548 catalytic triad [active] 1002672003549 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1002672003550 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1002672003551 dimerization interface [polypeptide binding]; other site 1002672003552 ATP binding site [chemical binding]; other site 1002672003553 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1002672003554 dimerization interface [polypeptide binding]; other site 1002672003555 ATP binding site [chemical binding]; other site 1002672003556 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1002672003557 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1002672003558 putative GSH binding site [chemical binding]; other site 1002672003559 catalytic residues [active] 1002672003560 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1002672003561 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1002672003562 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1002672003563 RNA binding surface [nucleotide binding]; other site 1002672003564 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1002672003565 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1002672003566 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1002672003567 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1002672003568 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1002672003569 active site 1002672003570 catalytic residues [active] 1002672003571 metal binding site [ion binding]; metal-binding site 1002672003572 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1002672003573 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1002672003574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1002672003575 active site 1002672003576 HIGH motif; other site 1002672003577 nucleotide binding site [chemical binding]; other site 1002672003578 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1002672003579 KMSKS motif; other site 1002672003580 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1002672003581 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1002672003582 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1002672003583 homodimer interface [polypeptide binding]; other site 1002672003584 NAD binding pocket [chemical binding]; other site 1002672003585 ATP binding pocket [chemical binding]; other site 1002672003586 Mg binding site [ion binding]; other site 1002672003587 active-site loop [active] 1002672003588 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1002672003589 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 1002672003590 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1002672003591 putative active site [active] 1002672003592 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1002672003593 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1002672003594 glutaminase active site [active] 1002672003595 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1002672003596 dimer interface [polypeptide binding]; other site 1002672003597 active site 1002672003598 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1002672003599 dimer interface [polypeptide binding]; other site 1002672003600 active site 1002672003601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672003602 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1002672003603 active site 1002672003604 substrate binding site [chemical binding]; other site 1002672003605 CoA binding site [chemical binding]; other site 1002672003606 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672003607 active site 1002672003608 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1002672003609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1002672003610 motif II; other site 1002672003611 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1002672003612 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1002672003613 tetramer interface [polypeptide binding]; other site 1002672003614 active site 1002672003615 Mg2+/Mn2+ binding site [ion binding]; other site 1002672003616 citrate synthase; Provisional; Region: PRK14033 1002672003617 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1002672003618 oxalacetate binding site [chemical binding]; other site 1002672003619 citrylCoA binding site [chemical binding]; other site 1002672003620 coenzyme A binding site [chemical binding]; other site 1002672003621 catalytic triad [active] 1002672003622 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1002672003623 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1002672003624 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672003625 EamA-like transporter family; Region: EamA; pfam00892 1002672003626 EamA-like transporter family; Region: EamA; pfam00892 1002672003627 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1002672003628 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1002672003629 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1002672003630 dimer interface [polypeptide binding]; other site 1002672003631 putative radical transfer pathway; other site 1002672003632 diiron center [ion binding]; other site 1002672003633 tyrosyl radical; other site 1002672003634 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 1002672003635 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1002672003636 active site 1002672003637 dimer interface [polypeptide binding]; other site 1002672003638 catalytic residues [active] 1002672003639 effector binding site; other site 1002672003640 R2 peptide binding site; other site 1002672003641 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1002672003642 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1002672003643 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1002672003644 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1002672003645 active site 1002672003646 metal binding site [ion binding]; metal-binding site 1002672003647 substrate binding site [chemical binding]; other site 1002672003648 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1002672003649 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1002672003650 nucleotide binding site/active site [active] 1002672003651 HIT family signature motif; other site 1002672003652 catalytic residue [active] 1002672003653 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1002672003654 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1002672003655 homodimer interface [polypeptide binding]; other site 1002672003656 chemical substrate binding site [chemical binding]; other site 1002672003657 oligomer interface [polypeptide binding]; other site 1002672003658 metal binding site [ion binding]; metal-binding site 1002672003659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1002672003660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1002672003661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1002672003662 enoyl-CoA hydratase; Provisional; Region: PRK06144 1002672003663 substrate binding site [chemical binding]; other site 1002672003664 oxyanion hole (OAH) forming residues; other site 1002672003665 trimer interface [polypeptide binding]; other site 1002672003666 DctM-like transporters; Region: DctM; pfam06808 1002672003667 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1002672003668 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1002672003669 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1002672003670 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1002672003671 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1002672003672 homodimer interface [polypeptide binding]; other site 1002672003673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1002672003674 catalytic residue [active] 1002672003675 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1002672003676 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1002672003677 active site pocket [active] 1002672003678 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1002672003679 FAD binding domain; Region: FAD_binding_4; pfam01565 1002672003680 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1002672003681 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1002672003682 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1002672003683 putative active site [active] 1002672003684 Zn binding site [ion binding]; other site 1002672003685 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1002672003686 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1002672003687 putative sugar binding sites [chemical binding]; other site 1002672003688 Q-X-W motif; other site 1002672003689 SOUL heme-binding protein; Region: SOUL; pfam04832 1002672003690 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1002672003691 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1002672003692 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1002672003693 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1002672003694 potential frameshift: common BLAST hit: gi|110834225|ref|YP_693084.1| copper-binding protein 1002672003695 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1002672003696 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1002672003697 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1002672003698 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1002672003699 NADP binding site [chemical binding]; other site 1002672003700 dimer interface [polypeptide binding]; other site 1002672003701 dihydroorotase; Validated; Region: PRK09060 1002672003702 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1002672003703 active site 1002672003704 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1002672003705 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1002672003706 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1002672003707 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1002672003708 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1002672003709 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1002672003710 NAD(P) binding site [chemical binding]; other site 1002672003711 catalytic residues [active] 1002672003712 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1002672003713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1002672003714 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1002672003715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1002672003716 Walker A/P-loop; other site 1002672003717 ATP binding site [chemical binding]; other site 1002672003718 Q-loop/lid; other site 1002672003719 ABC transporter signature motif; other site 1002672003720 Walker B; other site 1002672003721 D-loop; other site 1002672003722 H-loop/switch region; other site 1002672003723 Predicted ATPase [General function prediction only]; Region: COG1485 1002672003724 Predicted ATPase [General function prediction only]; Region: COG1485 1002672003725 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1002672003726 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1002672003727 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1002672003728 Domain of unknown function DUF59; Region: DUF59; cl00941 1002672003729 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1002672003730 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1002672003731 trimerization site [polypeptide binding]; other site 1002672003732 active site 1002672003733 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1002672003734 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1002672003735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1002672003736 catalytic residue [active] 1002672003737 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1002672003738 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1002672003739 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1002672003740 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1002672003741 Walker A/P-loop; other site 1002672003742 ATP binding site [chemical binding]; other site 1002672003743 Q-loop/lid; other site 1002672003744 ABC transporter signature motif; other site 1002672003745 Walker B; other site 1002672003746 D-loop; other site 1002672003747 H-loop/switch region; other site 1002672003748 putative ABC transporter; Region: ycf24; CHL00085 1002672003749 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1002672003750 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1002672003751 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1002672003752 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1002672003753 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1002672003754 active site 1002672003755 HIGH motif; other site 1002672003756 dimer interface [polypeptide binding]; other site 1002672003757 KMSKS motif; other site 1002672003758 peptide chain release factor 2; Provisional; Region: PRK07342 1002672003759 PCRF domain; Region: PCRF; pfam03462 1002672003760 RF-1 domain; Region: RF-1; pfam00472 1002672003761 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1002672003762 Transglycosylase; Region: Transgly; pfam00912 1002672003763 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1002672003764 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1002672003765 RNA binding site [nucleotide binding]; other site 1002672003766 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1002672003767 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1002672003768 Predicted flavoproteins [General function prediction only]; Region: COG2081 1002672003769 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1002672003770 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1002672003771 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1002672003772 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1002672003773 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1002672003774 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1002672003775 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1002672003776 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1002672003777 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1002672003778 active site 1002672003779 oxyanion hole [active] 1002672003780 switch loop; other site 1002672003781 catalytic triad [active] 1002672003782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1002672003783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1002672003784 Walker A/P-loop; other site 1002672003785 ATP binding site [chemical binding]; other site 1002672003786 Q-loop/lid; other site 1002672003787 ABC transporter signature motif; other site 1002672003788 Walker B; other site 1002672003789 D-loop; other site 1002672003790 H-loop/switch region; other site 1002672003791 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1002672003792 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1002672003793 FtsX-like permease family; Region: FtsX; pfam02687 1002672003794 tricarballylate dehydrogenase; Validated; Region: PRK08274 1002672003795 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1002672003796 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1002672003797 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1002672003798 trimer interface [polypeptide binding]; other site 1002672003799 putative metal binding site [ion binding]; other site 1002672003800 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1002672003801 putative catalytic residue [active] 1002672003802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1002672003803 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1002672003804 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1002672003805 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1002672003806 putative active site [active] 1002672003807 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1002672003808 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1002672003809 nitrilase; Region: PLN02798 1002672003810 putative active site [active] 1002672003811 catalytic triad [active] 1002672003812 dimer interface [polypeptide binding]; other site 1002672003813 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1002672003814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1002672003815 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1002672003816 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1002672003817 active site 1002672003818 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672003819 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1002672003820 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1002672003821 Staphylococcal nuclease homologues; Region: SNc; smart00318 1002672003822 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1002672003823 Catalytic site; other site 1002672003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672003825 dimer interface [polypeptide binding]; other site 1002672003826 conserved gate region; other site 1002672003827 ABC-ATPase subunit interface; other site 1002672003828 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1002672003829 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1002672003830 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1002672003831 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1002672003832 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1002672003833 ABC-ATPase subunit interface; other site 1002672003834 dimer interface [polypeptide binding]; other site 1002672003835 putative PBP binding regions; other site 1002672003836 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1002672003837 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1002672003838 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1002672003839 intersubunit interface [polypeptide binding]; other site 1002672003840 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1002672003841 metal binding site [ion binding]; metal-binding site 1002672003842 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1002672003843 metal binding site 2 [ion binding]; metal-binding site 1002672003844 putative DNA binding helix; other site 1002672003845 metal binding site 1 [ion binding]; metal-binding site 1002672003846 structural Zn2+ binding site [ion binding]; other site 1002672003847 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1002672003848 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1002672003849 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1002672003850 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1002672003851 heme binding site [chemical binding]; other site 1002672003852 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1002672003853 heme binding site [chemical binding]; other site 1002672003854 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1002672003855 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1002672003856 Walker A/P-loop; other site 1002672003857 ATP binding site [chemical binding]; other site 1002672003858 Q-loop/lid; other site 1002672003859 ABC transporter signature motif; other site 1002672003860 Walker B; other site 1002672003861 D-loop; other site 1002672003862 H-loop/switch region; other site 1002672003863 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1002672003864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672003865 dimer interface [polypeptide binding]; other site 1002672003866 conserved gate region; other site 1002672003867 putative PBP binding loops; other site 1002672003868 ABC-ATPase subunit interface; other site 1002672003869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1002672003870 dimer interface [polypeptide binding]; other site 1002672003871 conserved gate region; other site 1002672003872 putative PBP binding loops; other site 1002672003873 ABC-ATPase subunit interface; other site 1002672003874 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1002672003875 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1002672003876 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1002672003877 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1002672003878 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1002672003879 EamA-like transporter family; Region: EamA; pfam00892 1002672003880 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1002672003881 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1002672003882 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1002672003883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1002672003884 dimer interface [polypeptide binding]; other site 1002672003885 active site 1002672003886 metal binding site [ion binding]; metal-binding site 1002672003887 glutathione binding site [chemical binding]; other site 1002672003888 Cytochrome c; Region: Cytochrom_C; cl11414 1002672003889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1002672003890 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1002672003891 dimer interface [polypeptide binding]; other site 1002672003892 active site 1002672003893 metal binding site [ion binding]; metal-binding site 1002672003894 glutathione binding site [chemical binding]; other site 1002672003895 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1002672003896 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1002672003897 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1002672003898 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1002672003899 active site residue [active] 1002672003900 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1002672003901 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1002672003902 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1002672003903 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1002672003904 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1002672003905 Tetramer interface [polypeptide binding]; other site 1002672003906 active site 1002672003907 FMN-binding site [chemical binding]; other site 1002672003908 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1002672003909 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1002672003910 choline dehydrogenase; Validated; Region: PRK02106 1002672003911 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1002672003912 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1002672003913 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1002672003914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1002672003915 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1002672003916 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1002672003917 Bacterial Ig-like domain; Region: Big_5; pfam13205 1002672003918 Bacterial Ig-like domain; Region: Big_5; pfam13205 1002672003919 Bacterial Ig-like domain; Region: Big_5; pfam13205 1002672003920 Autotransporter beta-domain; Region: Autotransporter; smart00869 1002672003921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1002672003922 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1002672003923 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1002672003924 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1002672003925 TPP-binding site; other site 1002672003926 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1002672003927 PYR/PP interface [polypeptide binding]; other site 1002672003928 dimer interface [polypeptide binding]; other site 1002672003929 TPP binding site [chemical binding]; other site 1002672003930 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1002672003931 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1002672003932 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1002672003933 substrate binding pocket [chemical binding]; other site 1002672003934 chain length determination region; other site 1002672003935 substrate-Mg2+ binding site; other site 1002672003936 catalytic residues [active] 1002672003937 aspartate-rich region 1; other site 1002672003938 active site lid residues [active] 1002672003939 aspartate-rich region 2; other site 1002672003940 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1002672003941 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1002672003942 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1002672003943 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1002672003944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1002672003945 Walker A/P-loop; other site 1002672003946 ATP binding site [chemical binding]; other site 1002672003947 Q-loop/lid; other site 1002672003948 ABC transporter signature motif; other site 1002672003949 Walker B; other site 1002672003950 D-loop; other site 1002672003951 H-loop/switch region; other site 1002672003952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1002672003953 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1002672003954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1002672003955 RNA binding surface [nucleotide binding]; other site 1002672003956 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1002672003957 active site 1002672003958 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1002672003959 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1002672003960 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1002672003961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1002672003962 DNA binding residues [nucleotide binding] 1002672003963 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1002672003964 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1002672003965 GDP-binding site [chemical binding]; other site 1002672003966 ACT binding site; other site 1002672003967 IMP binding site; other site 1002672003968 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1002672003969 dimer interface [polypeptide binding]; other site 1002672003970 substrate binding site [chemical binding]; other site 1002672003971 ATP binding site [chemical binding]; other site 1002672003972 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1002672003973 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1002672003974 active site 1002672003975 substrate binding site [chemical binding]; other site 1002672003976 metal binding site [ion binding]; metal-binding site 1002672003977 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1002672003978 dihydropteroate synthase; Region: DHPS; TIGR01496 1002672003979 substrate binding pocket [chemical binding]; other site 1002672003980 dimer interface [polypeptide binding]; other site 1002672003981 inhibitor binding site; inhibition site 1002672003982 FtsH Extracellular; Region: FtsH_ext; pfam06480 1002672003983 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1002672003984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1002672003985 Walker A motif; other site 1002672003986 ATP binding site [chemical binding]; other site 1002672003987 Walker B motif; other site 1002672003988 arginine finger; other site 1002672003989 Peptidase family M41; Region: Peptidase_M41; pfam01434 1002672003990 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1002672003991 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1002672003992 Ligand Binding Site [chemical binding]; other site 1002672003993 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1002672003994 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1002672003995 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1002672003996 ligand binding site [chemical binding]; other site 1002672003997 translocation protein TolB; Provisional; Region: tolB; PRK05137 1002672003998 TolB amino-terminal domain; Region: TolB_N; pfam04052 1002672003999 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1002672004000 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1002672004001 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1002672004002 TolR protein; Region: tolR; TIGR02801 1002672004003 TolQ protein; Region: tolQ; TIGR02796 1002672004004 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1002672004005 active site 1002672004006 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1002672004007 hypothetical protein; Validated; Region: PRK00110 1002672004008 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1002672004009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1002672004010 putative active site [active] 1002672004011 metal binding site [ion binding]; metal-binding site 1002672004012 homodimer binding site [polypeptide binding]; other site 1002672004013 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1002672004014 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1002672004015 Cell division protein ZapA; Region: ZapA; pfam05164 1002672004016 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1002672004017 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1002672004018 TPP-binding site [chemical binding]; other site 1002672004019 dimer interface [polypeptide binding]; other site 1002672004020 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1002672004021 PYR/PP interface [polypeptide binding]; other site 1002672004022 dimer interface [polypeptide binding]; other site 1002672004023 TPP binding site [chemical binding]; other site 1002672004024 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1002672004025 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1002672004026 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1002672004027 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1002672004028 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1002672004029 Phosphoglycerate kinase; Region: PGK; pfam00162 1002672004030 substrate binding site [chemical binding]; other site 1002672004031 hinge regions; other site 1002672004032 ADP binding site [chemical binding]; other site 1002672004033 catalytic site [active] 1002672004034 Class I aldolases; Region: Aldolase_Class_I; cl17187 1002672004035 catalytic residue [active] 1002672004036 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1002672004037 thiamine phosphate binding site [chemical binding]; other site 1002672004038 active site 1002672004039 pyrophosphate binding site [ion binding]; other site 1002672004040 elongation factor P; Validated; Region: PRK00529 1002672004041 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1002672004042 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1002672004043 RNA binding site [nucleotide binding]; other site 1002672004044 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1002672004045 RNA binding site [nucleotide binding]; other site 1002672004046 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1002672004047 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1002672004048 active site 1002672004049 dimerization interface [polypeptide binding]; other site 1002672004050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1002672004051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1002672004052 putative substrate translocation pore; other site 1002672004053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1002672004054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1002672004055 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1002672004056 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 1002672004057 AIR carboxylase; Region: AIRC; pfam00731 1002672004058 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1002672004059 ATP-grasp domain; Region: ATP-grasp; pfam02222 1002672004060 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 1002672004061 COQ9; Region: COQ9; pfam08511 1002672004062 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1002672004063 rod shape-determining protein MreC; Region: MreC; pfam04085 1002672004064 rod shape-determining protein MreB; Provisional; Region: PRK13927 1002672004065 MreB and similar proteins; Region: MreB_like; cd10225 1002672004066 nucleotide binding site [chemical binding]; other site 1002672004067 Mg binding site [ion binding]; other site 1002672004068 putative protofilament interaction site [polypeptide binding]; other site 1002672004069 RodZ interaction site [polypeptide binding]; other site 1002672004070 2-isopropylmalate synthase; Validated; Region: PRK00915 1002672004071 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1002672004072 metal binding site [ion binding]; metal-binding site 1002672004073 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917