-- dump date   	20140619_024538
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
335992000001	ketol-acid reductoisomerase; Provisional; Region: PRK05479
335992000002	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
335992000003	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
335992000004	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
335992000005	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
335992000006	putative valine binding site [chemical binding]; other site
335992000007	dimer interface [polypeptide binding]; other site
335992000008	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
335992000009	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
335992000010	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335992000011	PYR/PP interface [polypeptide binding]; other site
335992000012	dimer interface [polypeptide binding]; other site
335992000013	TPP binding site [chemical binding]; other site
335992000014	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335992000015	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
335992000016	TPP-binding site [chemical binding]; other site
335992000017	dimer interface [polypeptide binding]; other site
335992000018	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
335992000019	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
335992000020	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
335992000021	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335992000022	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335992000023	protein binding site [polypeptide binding]; other site
335992000024	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335992000025	protein binding site [polypeptide binding]; other site
335992000026	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
335992000027	HflC protein; Region: hflC; TIGR01932
335992000028	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
335992000029	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
335992000030	HflK protein; Region: hflK; TIGR01933
335992000031	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
335992000032	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
335992000033	Walker A motif; other site
335992000034	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
335992000035	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
335992000036	metal binding site [ion binding]; metal-binding site
335992000037	fumarate hydratase; Reviewed; Region: fumC; PRK00485
335992000038	Class II fumarases; Region: Fumarase_classII; cd01362
335992000039	active site
335992000040	tetramer interface [polypeptide binding]; other site
335992000041	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
335992000042	Part of AAA domain; Region: AAA_19; pfam13245
335992000043	Family description; Region: UvrD_C_2; pfam13538
335992000044	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
335992000045	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
335992000046	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
335992000047	active site
335992000048	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
335992000049	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
335992000050	nucleotide binding pocket [chemical binding]; other site
335992000051	K-X-D-G motif; other site
335992000052	catalytic site [active]
335992000053	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
335992000054	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
335992000055	Dimer interface [polypeptide binding]; other site
335992000056	BRCT sequence motif; other site
335992000057	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
335992000058	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
335992000059	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
335992000060	Cell division protein FtsA; Region: FtsA; cl17206
335992000061	Cell division protein FtsA; Region: FtsA; pfam14450
335992000062	Cell division protein FtsQ; Region: FtsQ; pfam03799
335992000063	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
335992000064	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
335992000065	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335992000066	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
335992000067	FAD binding domain; Region: FAD_binding_4; pfam01565
335992000068	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
335992000069	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
335992000070	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
335992000071	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335992000072	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
335992000073	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
335992000074	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
335992000075	active site
335992000076	homodimer interface [polypeptide binding]; other site
335992000077	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
335992000078	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01368
335992000079	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335992000080	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
335992000081	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
335992000082	Mg++ binding site [ion binding]; other site
335992000083	putative catalytic motif [active]
335992000084	putative substrate binding site [chemical binding]; other site
335992000085	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
335992000086	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
335992000087	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335992000088	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
335992000089	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
335992000090	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335992000091	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
335992000092	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
335992000093	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
335992000094	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
335992000095	MraW methylase family; Region: Methyltransf_5; cl17771
335992000096	cell division protein FtsZ; Validated; Region: PRK09330
335992000097	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
335992000098	nucleotide binding site [chemical binding]; other site
335992000099	SulA interaction site; other site
335992000100	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
335992000101	cell division protein MraZ; Reviewed; Region: PRK00326
335992000102	MraZ protein; Region: MraZ; pfam02381
335992000103	MraZ protein; Region: MraZ; pfam02381
335992000104	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
335992000105	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
335992000106	amidase catalytic site [active]
335992000107	Zn binding residues [ion binding]; other site
335992000108	substrate binding site [chemical binding]; other site
335992000109	VacJ like lipoprotein; Region: VacJ; cl01073
335992000110	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
335992000111	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
335992000112	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
335992000113	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
335992000114	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335992000115	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
335992000116	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335992000117	DNA binding residues [nucleotide binding]
335992000118	DNA primase; Validated; Region: dnaG; PRK05667
335992000119	CHC2 zinc finger; Region: zf-CHC2; cl17510
335992000120	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
335992000121	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
335992000122	active site
335992000123	metal binding site [ion binding]; metal-binding site
335992000124	interdomain interaction site; other site
335992000125	Uncharacterized conserved protein [Function unknown]; Region: COG1610
335992000126	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
335992000127	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
335992000128	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
335992000129	catalytic site [active]
335992000130	subunit interface [polypeptide binding]; other site
335992000131	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
335992000132	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335992000133	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
335992000134	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
335992000135	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335992000136	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335992000137	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
335992000138	IMP binding site; other site
335992000139	dimer interface [polypeptide binding]; other site
335992000140	interdomain contacts; other site
335992000141	partial ornithine binding site; other site
335992000142	Autotransporter beta-domain; Region: Autotransporter; smart00869
335992000143	Uncharacterized conserved protein [Function unknown]; Region: COG3391
335992000144	Autotransporter beta-domain; Region: Autotransporter; smart00869
335992000145	Autotransporter beta-domain; Region: Autotransporter; smart00869
335992000146	Sodium Bile acid symporter family; Region: SBF; cl17470
335992000147	bile acid transporter; Region: bass; TIGR00841
335992000148	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
335992000149	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
335992000150	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
335992000151	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
335992000152	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
335992000153	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
335992000154	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
335992000155	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
335992000156	anti sigma factor interaction site; other site
335992000157	regulatory phosphorylation site [posttranslational modification]; other site
335992000158	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
335992000159	anti sigma factor interaction site; other site
335992000160	regulatory phosphorylation site [posttranslational modification]; other site
335992000161	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
335992000162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
335992000163	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
335992000164	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
335992000165	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
335992000166	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
335992000167	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
335992000168	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
335992000169	Walker A motif; other site
335992000170	ATP binding site [chemical binding]; other site
335992000171	Walker B motif; other site
335992000172	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
335992000173	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
335992000174	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
335992000175	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
335992000176	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
335992000177	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335992000178	GAF domain; Region: GAF_3; pfam13492
335992000179	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
335992000180	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
335992000181	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
335992000182	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
335992000183	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
335992000184	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
335992000185	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
335992000186	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
335992000187	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
335992000188	Walker A motif; other site
335992000189	ATP binding site [chemical binding]; other site
335992000190	Walker B motif; other site
335992000191	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
335992000192	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
335992000193	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
335992000194	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
335992000195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335992000196	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
335992000197	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335992000198	NADP binding site [chemical binding]; other site
335992000199	putative substrate binding site [chemical binding]; other site
335992000200	active site
335992000201	Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
335992000202	aspartate aminotransferase; Provisional; Region: PRK05764
335992000203	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335992000204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992000205	homodimer interface [polypeptide binding]; other site
335992000206	catalytic residue [active]
335992000207	excinuclease ABC subunit B; Provisional; Region: PRK05298
335992000208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335992000209	ATP binding site [chemical binding]; other site
335992000210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335992000211	nucleotide binding region [chemical binding]; other site
335992000212	ATP-binding site [chemical binding]; other site
335992000213	Ultra-violet resistance protein B; Region: UvrB; pfam12344
335992000214	UvrB/uvrC motif; Region: UVR; pfam02151
335992000215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992000216	short chain dehydrogenase; Provisional; Region: PRK09134
335992000217	NAD(P) binding site [chemical binding]; other site
335992000218	active site
335992000219	Dihydroneopterin aldolase; Region: FolB; pfam02152
335992000220	active site
335992000221	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
335992000222	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
335992000223	GIY-YIG motif/motif A; other site
335992000224	active site
335992000225	catalytic site [active]
335992000226	putative DNA binding site [nucleotide binding]; other site
335992000227	metal binding site [ion binding]; metal-binding site
335992000228	UvrB/uvrC motif; Region: UVR; pfam02151
335992000229	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
335992000230	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
335992000231	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
335992000232	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
335992000233	homodimer interface [polypeptide binding]; other site
335992000234	substrate-cofactor binding pocket; other site
335992000235	catalytic residue [active]
335992000236	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335992000237	MarR family; Region: MarR_2; pfam12802
335992000238	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335992000239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335992000240	active site
335992000241	phosphorylation site [posttranslational modification]
335992000242	intermolecular recognition site; other site
335992000243	dimerization interface [polypeptide binding]; other site
335992000244	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335992000245	DNA binding site [nucleotide binding]
335992000246	HAMP domain; Region: HAMP; pfam00672
335992000247	dimerization interface [polypeptide binding]; other site
335992000248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335992000249	dimer interface [polypeptide binding]; other site
335992000250	phosphorylation site [posttranslational modification]
335992000251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335992000252	ATP binding site [chemical binding]; other site
335992000253	Mg2+ binding site [ion binding]; other site
335992000254	G-X-G motif; other site
335992000255	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
335992000256	Uncharacterized conserved protein [Function unknown]; Region: COG1565
335992000257	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
335992000258	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
335992000259	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
335992000260	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335992000261	active site
335992000262	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
335992000263	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
335992000264	5S rRNA interface [nucleotide binding]; other site
335992000265	CTC domain interface [polypeptide binding]; other site
335992000266	L16 interface [polypeptide binding]; other site
335992000267	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
335992000268	putative active site [active]
335992000269	catalytic residue [active]
335992000270	GTP-binding protein YchF; Reviewed; Region: PRK09601
335992000271	YchF GTPase; Region: YchF; cd01900
335992000272	G1 box; other site
335992000273	GTP/Mg2+ binding site [chemical binding]; other site
335992000274	Switch I region; other site
335992000275	G2 box; other site
335992000276	Switch II region; other site
335992000277	G3 box; other site
335992000278	G4 box; other site
335992000279	G5 box; other site
335992000280	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
335992000281	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
335992000282	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
335992000283	cytochrome b; Provisional; Region: CYTB; MTH00191
335992000284	Qi binding site; other site
335992000285	intrachain domain interface; other site
335992000286	interchain domain interface [polypeptide binding]; other site
335992000287	heme bH binding site [chemical binding]; other site
335992000288	heme bL binding site [chemical binding]; other site
335992000289	Qo binding site; other site
335992000290	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
335992000291	interchain domain interface [polypeptide binding]; other site
335992000292	intrachain domain interface; other site
335992000293	Qi binding site; other site
335992000294	Qo binding site; other site
335992000295	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
335992000296	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
335992000297	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
335992000298	[2Fe-2S] cluster binding site [ion binding]; other site
335992000299	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
335992000300	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
335992000301	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
335992000302	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
335992000303	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
335992000304	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
335992000305	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
335992000306	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
335992000307	active site
335992000308	NTP binding site [chemical binding]; other site
335992000309	metal binding triad [ion binding]; metal-binding site
335992000310	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
335992000311	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
335992000312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335992000313	binding surface
335992000314	TPR motif; other site
335992000315	TPR repeat; Region: TPR_11; pfam13414
335992000316	TPR repeat; Region: TPR_11; pfam13414
335992000317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335992000318	TPR motif; other site
335992000319	binding surface
335992000320	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
335992000321	Fe-S cluster binding site [ion binding]; other site
335992000322	active site
335992000323	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
335992000324	RNA/DNA hybrid binding site [nucleotide binding]; other site
335992000325	active site
335992000326	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
335992000327	DNA methylase; Region: N6_N4_Mtase; pfam01555
335992000328	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
335992000329	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335992000330	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
335992000331	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
335992000332	minor groove reading motif; other site
335992000333	helix-hairpin-helix signature motif; other site
335992000334	substrate binding pocket [chemical binding]; other site
335992000335	active site
335992000336	Protein of unknown function (DUF721); Region: DUF721; pfam05258
335992000337	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
335992000338	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
335992000339	catalytic residues [active]
335992000340	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
335992000341	AAA domain; Region: AAA_23; pfam13476
335992000342	Walker A/P-loop; other site
335992000343	ATP binding site [chemical binding]; other site
335992000344	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
335992000345	ABC transporter signature motif; other site
335992000346	Walker B; other site
335992000347	D-loop; other site
335992000348	H-loop/switch region; other site
335992000349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
335992000350	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
335992000351	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
335992000352	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
335992000353	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
335992000354	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
335992000355	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
335992000356	phytoene desaturase; Region: crtI_fam; TIGR02734
335992000357	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335992000358	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
335992000359	substrate binding pocket [chemical binding]; other site
335992000360	substrate-Mg2+ binding site; other site
335992000361	aspartate-rich region 1; other site
335992000362	aspartate-rich region 2; other site
335992000363	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
335992000364	lycopene cyclase; Region: lycopene_cycl; TIGR01789
335992000365	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
335992000366	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
335992000367	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
335992000368	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
335992000369	putative active site [active]
335992000370	putative substrate binding site [chemical binding]; other site
335992000371	ATP binding site [chemical binding]; other site
335992000372	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
335992000373	RNA/DNA hybrid binding site [nucleotide binding]; other site
335992000374	active site
335992000375	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
335992000376	catalytic triad [active]
335992000377	dimer interface [polypeptide binding]; other site
335992000378	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
335992000379	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
335992000380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992000381	catalytic residue [active]
335992000382	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
335992000383	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
335992000384	Subunit III/VIIa interface [polypeptide binding]; other site
335992000385	Phospholipid binding site [chemical binding]; other site
335992000386	Subunit I/III interface [polypeptide binding]; other site
335992000387	Subunit III/VIb interface [polypeptide binding]; other site
335992000388	Subunit III/VIa interface; other site
335992000389	Subunit III/Vb interface [polypeptide binding]; other site
335992000390	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
335992000391	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
335992000392	UbiA prenyltransferase family; Region: UbiA; pfam01040
335992000393	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
335992000394	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
335992000395	Subunit I/III interface [polypeptide binding]; other site
335992000396	D-pathway; other site
335992000397	Subunit I/VIIc interface [polypeptide binding]; other site
335992000398	Subunit I/IV interface [polypeptide binding]; other site
335992000399	Subunit I/II interface [polypeptide binding]; other site
335992000400	Low-spin heme (heme a) binding site [chemical binding]; other site
335992000401	Subunit I/VIIa interface [polypeptide binding]; other site
335992000402	Subunit I/VIa interface [polypeptide binding]; other site
335992000403	Dimer interface; other site
335992000404	Putative water exit pathway; other site
335992000405	Binuclear center (heme a3/CuB) [ion binding]; other site
335992000406	K-pathway; other site
335992000407	Subunit I/Vb interface [polypeptide binding]; other site
335992000408	Putative proton exit pathway; other site
335992000409	Subunit I/VIb interface; other site
335992000410	Subunit I/VIc interface [polypeptide binding]; other site
335992000411	Electron transfer pathway; other site
335992000412	Subunit I/VIIIb interface [polypeptide binding]; other site
335992000413	Subunit I/VIIb interface [polypeptide binding]; other site
335992000414	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
335992000415	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
335992000416	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
335992000417	RNA methyltransferase, RsmE family; Region: TIGR00046
335992000418	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
335992000419	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
335992000420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335992000421	motif II; other site
335992000422	Predicted transcriptional regulators [Transcription]; Region: COG1733
335992000423	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335992000424	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
335992000425	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
335992000426	Predicted membrane protein [Function unknown]; Region: COG2259
335992000427	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
335992000428	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
335992000429	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
335992000430	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
335992000431	active site
335992000432	FMN binding site [chemical binding]; other site
335992000433	substrate binding site [chemical binding]; other site
335992000434	3Fe-4S cluster binding site [ion binding]; other site
335992000435	Pirin-related protein [General function prediction only]; Region: COG1741
335992000436	Pirin; Region: Pirin; pfam02678
335992000437	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
335992000438	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
335992000439	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
335992000440	NADP binding site [chemical binding]; other site
335992000441	dimer interface [polypeptide binding]; other site
335992000442	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
335992000443	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
335992000444	UbiA prenyltransferase family; Region: UbiA; pfam01040
335992000445	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
335992000446	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335992000447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335992000448	Walker A/P-loop; other site
335992000449	ATP binding site [chemical binding]; other site
335992000450	Q-loop/lid; other site
335992000451	ABC transporter signature motif; other site
335992000452	Walker B; other site
335992000453	D-loop; other site
335992000454	H-loop/switch region; other site
335992000455	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
335992000456	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
335992000457	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
335992000458	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
335992000459	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
335992000460	putative acyl-acceptor binding pocket; other site
335992000461	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866
335992000462	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
335992000463	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
335992000464	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
335992000465	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
335992000466	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
335992000467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992000468	S-adenosylmethionine binding site [chemical binding]; other site
335992000469	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
335992000470	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
335992000471	dimer interface [polypeptide binding]; other site
335992000472	active site
335992000473	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
335992000474	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
335992000475	lipoprotein signal peptidase; Provisional; Region: PRK14787
335992000476	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
335992000477	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992000478	active site
335992000479	HIGH motif; other site
335992000480	nucleotide binding site [chemical binding]; other site
335992000481	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
335992000482	active site
335992000483	KMSKS motif; other site
335992000484	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
335992000485	tRNA binding surface [nucleotide binding]; other site
335992000486	anticodon binding site; other site
335992000487	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
335992000488	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
335992000489	active site
335992000490	Riboflavin kinase; Region: Flavokinase; pfam01687
335992000491	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
335992000492	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
335992000493	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
335992000494	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
335992000495	oligomerisation interface [polypeptide binding]; other site
335992000496	mobile loop; other site
335992000497	roof hairpin; other site
335992000498	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
335992000499	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
335992000500	ring oligomerisation interface [polypeptide binding]; other site
335992000501	ATP/Mg binding site [chemical binding]; other site
335992000502	stacking interactions; other site
335992000503	hinge regions; other site
335992000504	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
335992000505	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
335992000506	ATP binding site [chemical binding]; other site
335992000507	Mg++ binding site [ion binding]; other site
335992000508	motif III; other site
335992000509	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335992000510	nucleotide binding region [chemical binding]; other site
335992000511	ATP-binding site [chemical binding]; other site
335992000512	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
335992000513	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
335992000514	G1 box; other site
335992000515	putative GEF interaction site [polypeptide binding]; other site
335992000516	GTP/Mg2+ binding site [chemical binding]; other site
335992000517	Switch I region; other site
335992000518	G2 box; other site
335992000519	G3 box; other site
335992000520	Switch II region; other site
335992000521	G4 box; other site
335992000522	G5 box; other site
335992000523	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
335992000524	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
335992000525	Predicted membrane protein [Function unknown]; Region: COG2364
335992000526	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
335992000527	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
335992000528	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
335992000529	protease TldD; Provisional; Region: tldD; PRK10735
335992000530	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
335992000531	active site residue [active]
335992000532	Protein of unknown function, DUF393; Region: DUF393; pfam04134
335992000533	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335992000534	binding surface
335992000535	TPR motif; other site
335992000536	TPR repeat; Region: TPR_11; pfam13414
335992000537	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335992000538	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335992000539	inhibitor site; inhibition site
335992000540	active site
335992000541	dimer interface [polypeptide binding]; other site
335992000542	catalytic residue [active]
335992000543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992000544	NAD(P) binding site [chemical binding]; other site
335992000545	active site
335992000546	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
335992000547	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335992000548	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335992000549	HSP70 interaction site [polypeptide binding]; other site
335992000550	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
335992000551	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335992000552	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335992000553	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
335992000554	putative dimer interface [polypeptide binding]; other site
335992000555	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
335992000556	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335992000557	active site
335992000558	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
335992000559	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
335992000560	endonuclease III; Region: ENDO3c; smart00478
335992000561	minor groove reading motif; other site
335992000562	helix-hairpin-helix signature motif; other site
335992000563	substrate binding pocket [chemical binding]; other site
335992000564	active site
335992000565	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992000566	EamA-like transporter family; Region: EamA; cl17759
335992000567	methionine sulfoxide reductase A; Provisional; Region: PRK14054
335992000568	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
335992000569	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
335992000570	active site residue [active]
335992000571	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
335992000572	active site residue [active]
335992000573	HlyD family secretion protein; Region: HlyD_3; pfam13437
335992000574	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335992000575	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335992000576	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335992000577	catalytic residue [active]
335992000578	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335992000579	catalytic core [active]
335992000580	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335992000581	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
335992000582	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
335992000583	Substrate binding site; other site
335992000584	Phosphotransferase enzyme family; Region: APH; pfam01636
335992000585	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
335992000586	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
335992000587	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
335992000588	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
335992000589	homotetramer interface [polypeptide binding]; other site
335992000590	ligand binding site [chemical binding]; other site
335992000591	catalytic site [active]
335992000592	NAD binding site [chemical binding]; other site
335992000593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335992000594	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335992000595	dimer interface [polypeptide binding]; other site
335992000596	phosphorylation site [posttranslational modification]
335992000597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335992000598	ATP binding site [chemical binding]; other site
335992000599	Mg2+ binding site [ion binding]; other site
335992000600	G-X-G motif; other site
335992000601	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335992000602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335992000603	active site
335992000604	phosphorylation site [posttranslational modification]
335992000605	intermolecular recognition site; other site
335992000606	dimerization interface [polypeptide binding]; other site
335992000607	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335992000608	DNA binding site [nucleotide binding]
335992000609	DNA polymerase I; Provisional; Region: PRK05755
335992000610	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
335992000611	active site
335992000612	metal binding site 1 [ion binding]; metal-binding site
335992000613	putative 5' ssDNA interaction site; other site
335992000614	metal binding site 3; metal-binding site
335992000615	metal binding site 2 [ion binding]; metal-binding site
335992000616	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
335992000617	putative DNA binding site [nucleotide binding]; other site
335992000618	putative metal binding site [ion binding]; other site
335992000619	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
335992000620	active site
335992000621	catalytic site [active]
335992000622	substrate binding site [chemical binding]; other site
335992000623	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
335992000624	active site
335992000625	DNA binding site [nucleotide binding]
335992000626	catalytic site [active]
335992000627	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
335992000628	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
335992000629	Walker A/P-loop; other site
335992000630	ATP binding site [chemical binding]; other site
335992000631	Q-loop/lid; other site
335992000632	ABC transporter signature motif; other site
335992000633	Walker B; other site
335992000634	D-loop; other site
335992000635	H-loop/switch region; other site
335992000636	BioY family; Region: BioY; pfam02632
335992000637	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
335992000638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335992000639	active site
335992000640	phosphorylation site [posttranslational modification]
335992000641	intermolecular recognition site; other site
335992000642	dimerization interface [polypeptide binding]; other site
335992000643	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
335992000644	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
335992000645	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
335992000646	dimer interface [polypeptide binding]; other site
335992000647	active site
335992000648	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335992000649	catalytic residues [active]
335992000650	substrate binding site [chemical binding]; other site
335992000651	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
335992000652	deoxyhypusine synthase; Region: dhys; TIGR00321
335992000653	agmatinase; Region: agmatinase; TIGR01230
335992000654	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
335992000655	putative active site [active]
335992000656	Mn binding site [ion binding]; other site
335992000657	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
335992000658	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
335992000659	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
335992000660	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
335992000661	quinone interaction residues [chemical binding]; other site
335992000662	active site
335992000663	catalytic residues [active]
335992000664	FMN binding site [chemical binding]; other site
335992000665	substrate binding site [chemical binding]; other site
335992000666	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
335992000667	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992000668	active site
335992000669	nucleotide binding site [chemical binding]; other site
335992000670	HIGH motif; other site
335992000671	KMSKS motif; other site
335992000672	Cation transport protein; Region: TrkH; cl17365
335992000673	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
335992000674	muropeptide transporter; Reviewed; Region: ampG; PRK11902
335992000675	muropeptide transporter; Validated; Region: ampG; cl17669
335992000676	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
335992000677	NlpC/P60 family; Region: NLPC_P60; cl17555
335992000678	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
335992000679	prephenate dehydrogenase; Validated; Region: PRK08507
335992000680	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
335992000681	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335992000682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992000683	homodimer interface [polypeptide binding]; other site
335992000684	catalytic residue [active]
335992000685	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
335992000686	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
335992000687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992000688	S-adenosylmethionine binding site [chemical binding]; other site
335992000689	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
335992000690	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
335992000691	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
335992000692	GTPase CgtA; Reviewed; Region: obgE; PRK12299
335992000693	GTP1/OBG; Region: GTP1_OBG; pfam01018
335992000694	Obg GTPase; Region: Obg; cd01898
335992000695	G1 box; other site
335992000696	GTP/Mg2+ binding site [chemical binding]; other site
335992000697	Switch I region; other site
335992000698	G2 box; other site
335992000699	G3 box; other site
335992000700	Switch II region; other site
335992000701	G4 box; other site
335992000702	G5 box; other site
335992000703	gamma-glutamyl kinase; Provisional; Region: PRK05429
335992000704	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
335992000705	nucleotide binding site [chemical binding]; other site
335992000706	homotetrameric interface [polypeptide binding]; other site
335992000707	putative phosphate binding site [ion binding]; other site
335992000708	putative allosteric binding site; other site
335992000709	PUA domain; Region: PUA; pfam01472
335992000710	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
335992000711	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
335992000712	putative catalytic cysteine [active]
335992000713	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
335992000714	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
335992000715	active site
335992000716	(T/H)XGH motif; other site
335992000717	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
335992000718	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
335992000719	C-terminal peptidase (prc); Region: prc; TIGR00225
335992000720	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
335992000721	protein binding site [polypeptide binding]; other site
335992000722	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
335992000723	Catalytic dyad [active]
335992000724	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
335992000725	putative active site [active]
335992000726	Ap4A binding site [chemical binding]; other site
335992000727	nudix motif; other site
335992000728	putative metal binding site [ion binding]; other site
335992000729	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443
335992000730	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
335992000731	gamma subunit interface [polypeptide binding]; other site
335992000732	epsilon subunit interface [polypeptide binding]; other site
335992000733	LBP interface [polypeptide binding]; other site
335992000734	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
335992000735	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
335992000736	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
335992000737	alpha subunit interaction interface [polypeptide binding]; other site
335992000738	Walker A motif; other site
335992000739	ATP binding site [chemical binding]; other site
335992000740	Walker B motif; other site
335992000741	inhibitor binding site; inhibition site
335992000742	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
335992000743	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
335992000744	core domain interface [polypeptide binding]; other site
335992000745	delta subunit interface [polypeptide binding]; other site
335992000746	epsilon subunit interface [polypeptide binding]; other site
335992000747	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
335992000748	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
335992000749	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
335992000750	beta subunit interaction interface [polypeptide binding]; other site
335992000751	Walker A motif; other site
335992000752	ATP binding site [chemical binding]; other site
335992000753	Walker B motif; other site
335992000754	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
335992000755	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
335992000756	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
335992000757	primosome assembly protein PriA; Validated; Region: PRK05580
335992000758	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335992000759	ATP binding site [chemical binding]; other site
335992000760	putative Mg++ binding site [ion binding]; other site
335992000761	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335992000762	ATP-binding site [chemical binding]; other site
335992000763	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
335992000764	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335992000765	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335992000766	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
335992000767	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335992000768	2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
335992000769	E3 interaction surface; other site
335992000770	lipoyl attachment site [posttranslational modification]; other site
335992000771	e3 binding domain; Region: E3_binding; pfam02817
335992000772	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
335992000773	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
335992000774	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
335992000775	TPP-binding site [chemical binding]; other site
335992000776	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
335992000777	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
335992000778	CoA binding domain; Region: CoA_binding; pfam02629
335992000779	CoA-ligase; Region: Ligase_CoA; pfam00549
335992000780	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
335992000781	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
335992000782	CoA-ligase; Region: Ligase_CoA; pfam00549
335992000783	malate dehydrogenase; Reviewed; Region: PRK06223
335992000784	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
335992000785	NAD(P) binding site [chemical binding]; other site
335992000786	dimer interface [polypeptide binding]; other site
335992000787	tetramer (dimer of dimers) interface [polypeptide binding]; other site
335992000788	substrate binding site [chemical binding]; other site
335992000789	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
335992000790	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
335992000791	tetrameric interface [polypeptide binding]; other site
335992000792	NAD binding site [chemical binding]; other site
335992000793	catalytic residues [active]
335992000794	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
335992000795	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
335992000796	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
335992000797	L-aspartate oxidase; Provisional; Region: PRK06175
335992000798	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
335992000799	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
335992000800	putative SdhC subunit interface [polypeptide binding]; other site
335992000801	putative proximal heme binding site [chemical binding]; other site
335992000802	putative Iron-sulfur protein interface [polypeptide binding]; other site
335992000803	putative proximal quinone binding site; other site
335992000804	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
335992000805	Iron-sulfur protein interface; other site
335992000806	proximal quinone binding site [chemical binding]; other site
335992000807	SdhD (CybS) interface [polypeptide binding]; other site
335992000808	proximal heme binding site [chemical binding]; other site
335992000809	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
335992000810	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
335992000811	putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486
335992000812	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992000813	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335992000814	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335992000815	Serine hydrolase (FSH1); Region: FSH1; pfam03959
335992000816	acyl-CoA synthetase; Validated; Region: PRK08162
335992000817	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
335992000818	acyl-activating enzyme (AAE) consensus motif; other site
335992000819	putative active site [active]
335992000820	AMP binding site [chemical binding]; other site
335992000821	putative CoA binding site [chemical binding]; other site
335992000822	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
335992000823	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335992000824	active site
335992000825	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
335992000826	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
335992000827	tartrate dehydrogenase; Region: TTC; TIGR02089
335992000828	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
335992000829	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
335992000830	substrate binding site [chemical binding]; other site
335992000831	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
335992000832	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
335992000833	substrate binding site [chemical binding]; other site
335992000834	ligand binding site [chemical binding]; other site
335992000835	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
335992000836	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
335992000837	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
335992000838	signal recognition particle protein; Provisional; Region: PRK10867
335992000839	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
335992000840	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335992000841	Signal peptide binding domain; Region: SRP_SPB; pfam02978
335992000842	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
335992000843	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
335992000844	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
335992000845	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
335992000846	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
335992000847	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335992000848	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
335992000849	EamA-like transporter family; Region: EamA; pfam00892
335992000850	EamA-like transporter family; Region: EamA; pfam00892
335992000851	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335992000852	Amidase; Region: Amidase; cl11426
335992000853	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
335992000854	DctM-like transporters; Region: DctM; pfam06808
335992000855	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
335992000856	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
335992000857	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335992000858	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
335992000859	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
335992000860	Walker A/P-loop; other site
335992000861	ATP binding site [chemical binding]; other site
335992000862	Q-loop/lid; other site
335992000863	ABC transporter signature motif; other site
335992000864	Walker B; other site
335992000865	D-loop; other site
335992000866	H-loop/switch region; other site
335992000867	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
335992000868	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
335992000869	Walker A/P-loop; other site
335992000870	ATP binding site [chemical binding]; other site
335992000871	Q-loop/lid; other site
335992000872	ABC transporter signature motif; other site
335992000873	Walker B; other site
335992000874	D-loop; other site
335992000875	H-loop/switch region; other site
335992000876	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335992000877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992000878	dimer interface [polypeptide binding]; other site
335992000879	conserved gate region; other site
335992000880	putative PBP binding loops; other site
335992000881	ABC-ATPase subunit interface; other site
335992000882	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
335992000883	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335992000884	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
335992000885	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
335992000886	NAD binding site [chemical binding]; other site
335992000887	substrate binding site [chemical binding]; other site
335992000888	catalytic Zn binding site [ion binding]; other site
335992000889	structural Zn binding site [ion binding]; other site
335992000890	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
335992000891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335992000892	putative substrate translocation pore; other site
335992000893	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335992000894	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335992000895	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
335992000896	dimerization interface [polypeptide binding]; other site
335992000897	ligand binding site [chemical binding]; other site
335992000898	NADP binding site [chemical binding]; other site
335992000899	catalytic site [active]
335992000900	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
335992000901	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
335992000902	Cysteine-rich domain; Region: CCG; pfam02754
335992000903	Cysteine-rich domain; Region: CCG; pfam02754
335992000904	FAD binding domain; Region: FAD_binding_4; pfam01565
335992000905	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
335992000906	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
335992000907	FAD binding domain; Region: FAD_binding_4; pfam01565
335992000908	aspartate aminotransferase; Provisional; Region: PRK05764
335992000909	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335992000910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992000911	homodimer interface [polypeptide binding]; other site
335992000912	catalytic residue [active]
335992000913	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
335992000914	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
335992000915	phosphate binding site [ion binding]; other site
335992000916	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
335992000917	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
335992000918	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335992000919	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335992000920	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
335992000921	CcmE; Region: CcmE; pfam03100
335992000922	Heme exporter protein D (CcmD); Region: CcmD; cl11475
335992000923	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
335992000924	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
335992000925	intracellular septation protein A; Reviewed; Region: PRK00259
335992000926	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
335992000927	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
335992000928	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
335992000929	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335992000930	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335992000931	active site
335992000932	catalytic tetrad [active]
335992000933	argininosuccinate synthase; Provisional; Region: PRK13820
335992000934	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
335992000935	ANP binding site [chemical binding]; other site
335992000936	Substrate Binding Site II [chemical binding]; other site
335992000937	Substrate Binding Site I [chemical binding]; other site
335992000938	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
335992000939	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
335992000940	catalytic residues [active]
335992000941	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
335992000942	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
335992000943	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
335992000944	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
335992000945	catalytic triad [active]
335992000946	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
335992000947	Predicted membrane protein [Function unknown]; Region: COG1238
335992000948	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
335992000949	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
335992000950	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335992000951	classical (c) SDRs; Region: SDR_c; cd05233
335992000952	NAD(P) binding site [chemical binding]; other site
335992000953	active site
335992000954	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
335992000955	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
335992000956	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
335992000957	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
335992000958	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
335992000959	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
335992000960	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
335992000961	homodimer interface [polypeptide binding]; other site
335992000962	NADP binding site [chemical binding]; other site
335992000963	substrate binding site [chemical binding]; other site
335992000964	YGGT family; Region: YGGT; pfam02325
335992000965	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
335992000966	Mechanosensitive ion channel; Region: MS_channel; pfam00924
335992000967	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
335992000968	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
335992000969	active site
335992000970	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
335992000971	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
335992000972	domain interfaces; other site
335992000973	active site
335992000974	UGMP family protein; Validated; Region: PRK09604
335992000975	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
335992000976	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
335992000977	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
335992000978	EVE domain; Region: EVE; pfam01878
335992000979	acetyl-CoA synthetase; Provisional; Region: PRK00174
335992000980	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
335992000981	active site
335992000982	CoA binding site [chemical binding]; other site
335992000983	acyl-activating enzyme (AAE) consensus motif; other site
335992000984	AMP binding site [chemical binding]; other site
335992000985	acetate binding site [chemical binding]; other site
335992000986	putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647
335992000987	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
335992000988	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
335992000989	Na binding site [ion binding]; other site
335992000990	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
335992000991	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
335992000992	substrate binding site [chemical binding]; other site
335992000993	hexamer interface [polypeptide binding]; other site
335992000994	metal binding site [ion binding]; metal-binding site
335992000995	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
335992000996	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
335992000997	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
335992000998	purine monophosphate binding site [chemical binding]; other site
335992000999	dimer interface [polypeptide binding]; other site
335992001000	putative catalytic residues [active]
335992001001	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
335992001002	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
335992001003	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
335992001004	aromatic arch; other site
335992001005	DCoH dimer interaction site [polypeptide binding]; other site
335992001006	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
335992001007	DCoH tetramer interaction site [polypeptide binding]; other site
335992001008	substrate binding site [chemical binding]; other site
335992001009	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
335992001010	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
335992001011	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335992001012	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
335992001013	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
335992001014	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
335992001015	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
335992001016	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
335992001017	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
335992001018	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335992001019	Coenzyme A binding pocket [chemical binding]; other site
335992001020	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
335992001021	nucleotide binding site/active site [active]
335992001022	HIT family signature motif; other site
335992001023	catalytic residue [active]
335992001024	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
335992001025	metal binding site [ion binding]; metal-binding site
335992001026	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
335992001027	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
335992001028	substrate binding site [chemical binding]; other site
335992001029	glutamase interaction surface [polypeptide binding]; other site
335992001030	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
335992001031	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
335992001032	catalytic residues [active]
335992001033	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
335992001034	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
335992001035	putative active site [active]
335992001036	oxyanion strand; other site
335992001037	catalytic triad [active]
335992001038	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
335992001039	putative active site pocket [active]
335992001040	4-fold oligomerization interface [polypeptide binding]; other site
335992001041	metal binding residues [ion binding]; metal-binding site
335992001042	3-fold/trimer interface [polypeptide binding]; other site
335992001043	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
335992001044	active site
335992001045	HslU subunit interaction site [polypeptide binding]; other site
335992001046	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
335992001047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992001048	Walker A motif; other site
335992001049	ATP binding site [chemical binding]; other site
335992001050	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
335992001051	Walker B motif; other site
335992001052	arginine finger; other site
335992001053	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
335992001054	Smr domain; Region: Smr; pfam01713
335992001055	Tim44-like domain; Region: Tim44; pfam04280
335992001056	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
335992001057	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
335992001058	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
335992001059	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
335992001060	active site
335992001061	catalytic site [active]
335992001062	substrate binding site [chemical binding]; other site
335992001063	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
335992001064	dephospho-CoA kinase; Region: TIGR00152
335992001065	CoA-binding site [chemical binding]; other site
335992001066	ATP-binding [chemical binding]; other site
335992001067	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
335992001068	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
335992001069	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
335992001070	shikimate binding site; other site
335992001071	NAD(P) binding site [chemical binding]; other site
335992001072	Maf-like protein; Region: Maf; pfam02545
335992001073	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
335992001074	active site
335992001075	dimer interface [polypeptide binding]; other site
335992001076	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
335992001077	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
335992001078	Ferrochelatase; Region: Ferrochelatase; pfam00762
335992001079	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
335992001080	C-terminal domain interface [polypeptide binding]; other site
335992001081	active site
335992001082	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
335992001083	active site
335992001084	N-terminal domain interface [polypeptide binding]; other site
335992001085	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
335992001086	transcription termination factor Rho; Provisional; Region: rho; PRK09376
335992001087	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
335992001088	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
335992001089	RNA binding site [nucleotide binding]; other site
335992001090	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
335992001091	multimer interface [polypeptide binding]; other site
335992001092	Walker A motif; other site
335992001093	ATP binding site [chemical binding]; other site
335992001094	Walker B motif; other site
335992001095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
335992001096	TPR motif; other site
335992001097	binding surface
335992001098	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
335992001099	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
335992001100	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
335992001101	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335992001102	trmE is a tRNA modification GTPase; Region: trmE; cd04164
335992001103	G1 box; other site
335992001104	Walker A/P-loop; other site
335992001105	GTP/Mg2+ binding site [chemical binding]; other site
335992001106	ATP binding site [chemical binding]; other site
335992001107	Switch I region; other site
335992001108	G2 box; other site
335992001109	Switch II region; other site
335992001110	G3 box; other site
335992001111	G4 box; other site
335992001112	G5 box; other site
335992001113	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
335992001114	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
335992001115	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
335992001116	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
335992001117	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
335992001118	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
335992001119	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335992001120	P-loop; other site
335992001121	Magnesium ion binding site [ion binding]; other site
335992001122	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335992001123	Magnesium ion binding site [ion binding]; other site
335992001124	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
335992001125	ParB-like nuclease domain; Region: ParBc; pfam02195
335992001126	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
335992001127	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
335992001128	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
335992001129	HIGH motif; other site
335992001130	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
335992001131	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992001132	active site
335992001133	KMSKS motif; other site
335992001134	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
335992001135	tRNA binding surface [nucleotide binding]; other site
335992001136	anticodon binding site; other site
335992001137	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
335992001138	Gram-negative porin; Region: Porin_4; pfam13609
335992001139	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
335992001140	active site
335992001141	thiamine phosphate binding site [chemical binding]; other site
335992001142	pyrophosphate binding site [ion binding]; other site
335992001143	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
335992001144	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335992001145	catalytic residue [active]
335992001146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
335992001147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335992001148	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
335992001149	DNA binding site [nucleotide binding]
335992001150	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
335992001151	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335992001152	substrate binding site [chemical binding]; other site
335992001153	ATP binding site [chemical binding]; other site
335992001154	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
335992001155	endonuclease III; Region: ENDO3c; smart00478
335992001156	minor groove reading motif; other site
335992001157	helix-hairpin-helix signature motif; other site
335992001158	substrate binding pocket [chemical binding]; other site
335992001159	active site
335992001160	dihydrodipicolinate reductase; Provisional; Region: PRK00048
335992001161	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
335992001162	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
335992001163	chaperone protein DnaJ; Provisional; Region: PRK10767
335992001164	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335992001165	HSP70 interaction site [polypeptide binding]; other site
335992001166	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
335992001167	substrate binding site [polypeptide binding]; other site
335992001168	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
335992001169	Zn binding sites [ion binding]; other site
335992001170	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
335992001171	dimer interface [polypeptide binding]; other site
335992001172	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
335992001173	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
335992001174	nucleotide binding site [chemical binding]; other site
335992001175	NEF interaction site [polypeptide binding]; other site
335992001176	SBD interface [polypeptide binding]; other site
335992001177	GrpE; Region: GrpE; pfam01025
335992001178	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
335992001179	dimer interface [polypeptide binding]; other site
335992001180	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
335992001181	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
335992001182	active site
335992001183	dimerization interface [polypeptide binding]; other site
335992001184	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335992001185	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
335992001186	putative ligand binding site [chemical binding]; other site
335992001187	Predicted methyltransferases [General function prediction only]; Region: COG0313
335992001188	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
335992001189	putative SAM binding site [chemical binding]; other site
335992001190	putative homodimer interface [polypeptide binding]; other site
335992001191	outer membrane lipoprotein; Provisional; Region: PRK11023
335992001192	BON domain; Region: BON; pfam04972
335992001193	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
335992001194	Malic enzyme, N-terminal domain; Region: malic; pfam00390
335992001195	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
335992001196	putative NAD(P) binding site [chemical binding]; other site
335992001197	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
335992001198	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
335992001199	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
335992001200	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
335992001201	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
335992001202	active site
335992001203	HIGH motif; other site
335992001204	dimer interface [polypeptide binding]; other site
335992001205	KMSKS motif; other site
335992001206	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
335992001207	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
335992001208	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
335992001209	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335992001210	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
335992001211	putative active site [active]
335992001212	putative metal binding site [ion binding]; other site
335992001213	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
335992001214	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335992001215	metal binding site 2 [ion binding]; metal-binding site
335992001216	putative DNA binding helix; other site
335992001217	metal binding site 1 [ion binding]; metal-binding site
335992001218	dimer interface [polypeptide binding]; other site
335992001219	structural Zn2+ binding site [ion binding]; other site
335992001220	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
335992001221	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
335992001222	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335992001223	FeS/SAM binding site; other site
335992001224	TRAM domain; Region: TRAM; cl01282
335992001225	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
335992001226	PhoH-like protein; Region: PhoH; pfam02562
335992001227	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
335992001228	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
335992001229	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
335992001230	putative active site [active]
335992001231	catalytic triad [active]
335992001232	putative dimer interface [polypeptide binding]; other site
335992001233	S-adenosylmethionine synthetase; Validated; Region: PRK05250
335992001234	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
335992001235	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
335992001236	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
335992001237	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
335992001238	NusA N-terminal domain; Region: NusA_N; pfam08529
335992001239	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
335992001240	RNA binding site [nucleotide binding]; other site
335992001241	homodimer interface [polypeptide binding]; other site
335992001242	NusA-like KH domain; Region: KH_5; pfam13184
335992001243	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
335992001244	G-X-X-G motif; other site
335992001245	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
335992001246	translation initiation factor IF-2; Validated; Region: infB; PRK05306
335992001247	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
335992001248	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
335992001249	G1 box; other site
335992001250	putative GEF interaction site [polypeptide binding]; other site
335992001251	GTP/Mg2+ binding site [chemical binding]; other site
335992001252	Switch I region; other site
335992001253	G2 box; other site
335992001254	G3 box; other site
335992001255	Switch II region; other site
335992001256	G4 box; other site
335992001257	G5 box; other site
335992001258	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
335992001259	Translation-initiation factor 2; Region: IF-2; pfam11987
335992001260	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
335992001261	Ribosome-binding factor A; Region: RBFA; pfam02033
335992001262	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
335992001263	16S/18S rRNA binding site [nucleotide binding]; other site
335992001264	S13e-L30e interaction site [polypeptide binding]; other site
335992001265	25S rRNA binding site [nucleotide binding]; other site
335992001266	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
335992001267	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
335992001268	RNase E interface [polypeptide binding]; other site
335992001269	trimer interface [polypeptide binding]; other site
335992001270	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
335992001271	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
335992001272	RNase E interface [polypeptide binding]; other site
335992001273	trimer interface [polypeptide binding]; other site
335992001274	active site
335992001275	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
335992001276	putative nucleic acid binding region [nucleotide binding]; other site
335992001277	G-X-X-G motif; other site
335992001278	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
335992001279	RNA binding site [nucleotide binding]; other site
335992001280	domain interface; other site
335992001281	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
335992001282	Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050
335992001283	Cupin domain; Region: Cupin_2; pfam07883
335992001284	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
335992001285	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
335992001286	NAD binding site [chemical binding]; other site
335992001287	homotetramer interface [polypeptide binding]; other site
335992001288	homodimer interface [polypeptide binding]; other site
335992001289	substrate binding site [chemical binding]; other site
335992001290	active site
335992001291	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
335992001292	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
335992001293	dimer interface [polypeptide binding]; other site
335992001294	active site
335992001295	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
335992001296	active site 1 [active]
335992001297	dimer interface [polypeptide binding]; other site
335992001298	active site 2 [active]
335992001299	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335992001300	metal binding site 2 [ion binding]; metal-binding site
335992001301	putative DNA binding helix; other site
335992001302	metal binding site 1 [ion binding]; metal-binding site
335992001303	dimer interface [polypeptide binding]; other site
335992001304	structural Zn2+ binding site [ion binding]; other site
335992001305	Rubrerythrin [Energy production and conversion]; Region: COG1592
335992001306	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
335992001307	binuclear metal center [ion binding]; other site
335992001308	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
335992001309	Cysteine-rich domain; Region: CCG; pfam02754
335992001310	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
335992001311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
335992001312	Bacterial SH3 domain; Region: SH3_4; pfam06347
335992001313	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
335992001314	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
335992001315	ATP binding site [chemical binding]; other site
335992001316	substrate interface [chemical binding]; other site
335992001317	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
335992001318	trimer interface [polypeptide binding]; other site
335992001319	active site
335992001320	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
335992001321	Flavoprotein; Region: Flavoprotein; pfam02441
335992001322	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
335992001323	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
335992001324	ABC1 family; Region: ABC1; cl17513
335992001325	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
335992001326	active site
335992001327	ATP binding site [chemical binding]; other site
335992001328	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
335992001329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992001330	S-adenosylmethionine binding site [chemical binding]; other site
335992001331	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
335992001332	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
335992001333	DNA binding site [nucleotide binding]
335992001334	catalytic residue [active]
335992001335	H2TH interface [polypeptide binding]; other site
335992001336	putative catalytic residues [active]
335992001337	turnover-facilitating residue; other site
335992001338	intercalation triad [nucleotide binding]; other site
335992001339	8OG recognition residue [nucleotide binding]; other site
335992001340	putative reading head residues; other site
335992001341	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
335992001342	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
335992001343	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
335992001344	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
335992001345	DnaA N-terminal domain; Region: DnaA_N; pfam11638
335992001346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992001347	Walker A motif; other site
335992001348	ATP binding site [chemical binding]; other site
335992001349	Walker B motif; other site
335992001350	arginine finger; other site
335992001351	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
335992001352	DnaA box-binding interface [nucleotide binding]; other site
335992001353	DNA polymerase III subunit beta; Validated; Region: PRK05643
335992001354	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
335992001355	putative DNA binding surface [nucleotide binding]; other site
335992001356	dimer interface [polypeptide binding]; other site
335992001357	beta-clamp/clamp loader binding surface; other site
335992001358	beta-clamp/translesion DNA polymerase binding surface; other site
335992001359	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
335992001360	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
335992001361	putative acyl-acceptor binding pocket; other site
335992001362	diaminopimelate decarboxylase; Region: lysA; TIGR01048
335992001363	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
335992001364	active site
335992001365	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335992001366	substrate binding site [chemical binding]; other site
335992001367	catalytic residues [active]
335992001368	dimer interface [polypeptide binding]; other site
335992001369	argininosuccinate lyase; Provisional; Region: PRK00855
335992001370	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
335992001371	active sites [active]
335992001372	tetramer interface [polypeptide binding]; other site
335992001373	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
335992001374	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335992001375	catalytic residues [active]
335992001376	Predicted esterase [General function prediction only]; Region: COG0400
335992001377	putative hydrolase; Provisional; Region: PRK11460
335992001378	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
335992001379	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
335992001380	active site
335992001381	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
335992001382	diiron binding motif [ion binding]; other site
335992001383	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
335992001384	Predicted membrane protein [Function unknown]; Region: COG1238
335992001385	AMP-binding enzyme; Region: AMP-binding; pfam00501
335992001386	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335992001387	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
335992001388	acyl-activating enzyme (AAE) consensus motif; other site
335992001389	putative AMP binding site [chemical binding]; other site
335992001390	putative active site [active]
335992001391	putative CoA binding site [chemical binding]; other site
335992001392	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
335992001393	Ferredoxin [Energy production and conversion]; Region: COG1146
335992001394	4Fe-4S binding domain; Region: Fer4; cl02805
335992001395	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
335992001396	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
335992001397	putative metal binding site [ion binding]; other site
335992001398	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
335992001399	ATP binding site [chemical binding]; other site
335992001400	putative Mg++ binding site [ion binding]; other site
335992001401	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335992001402	nucleotide binding region [chemical binding]; other site
335992001403	ATP-binding site [chemical binding]; other site
335992001404	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335992001405	CoenzymeA binding site [chemical binding]; other site
335992001406	subunit interaction site [polypeptide binding]; other site
335992001407	PHB binding site; other site
335992001408	putative acyltransferase; Provisional; Region: PRK05790
335992001409	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335992001410	dimer interface [polypeptide binding]; other site
335992001411	active site
335992001412	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335992001413	E3 interaction surface; other site
335992001414	lipoyl attachment site [posttranslational modification]; other site
335992001415	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
335992001416	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
335992001417	dimer interface [polypeptide binding]; other site
335992001418	TPP-binding site [chemical binding]; other site
335992001419	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
335992001420	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
335992001421	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335992001422	E3 interaction surface; other site
335992001423	lipoyl attachment site [posttranslational modification]; other site
335992001424	e3 binding domain; Region: E3_binding; pfam02817
335992001425	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
335992001426	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992001427	EamA-like transporter family; Region: EamA; pfam00892
335992001428	EamA-like transporter family; Region: EamA; pfam00892
335992001429	Bacitracin resistance protein BacA; Region: BacA; pfam02673
335992001430	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
335992001431	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335992001432	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335992001433	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
335992001434	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
335992001435	active site
335992001436	dimer interface [polypeptide binding]; other site
335992001437	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
335992001438	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
335992001439	active site
335992001440	FMN binding site [chemical binding]; other site
335992001441	substrate binding site [chemical binding]; other site
335992001442	3Fe-4S cluster binding site [ion binding]; other site
335992001443	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
335992001444	domain interface; other site
335992001445	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
335992001446	putative NAD(P) binding site [chemical binding]; other site
335992001447	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335992001448	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335992001449	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
335992001450	putative ADP-binding pocket [chemical binding]; other site
335992001451	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992001452	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
335992001453	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
335992001454	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
335992001455	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
335992001456	active site
335992001457	dimer interface [polypeptide binding]; other site
335992001458	motif 1; other site
335992001459	motif 2; other site
335992001460	motif 3; other site
335992001461	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
335992001462	anticodon binding site; other site
335992001463	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
335992001464	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
335992001465	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
335992001466	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
335992001467	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
335992001468	23S rRNA binding site [nucleotide binding]; other site
335992001469	L21 binding site [polypeptide binding]; other site
335992001470	L13 binding site [polypeptide binding]; other site
335992001471	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
335992001472	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
335992001473	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
335992001474	dimer interface [polypeptide binding]; other site
335992001475	motif 1; other site
335992001476	active site
335992001477	motif 2; other site
335992001478	motif 3; other site
335992001479	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
335992001480	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
335992001481	putative tRNA-binding site [nucleotide binding]; other site
335992001482	B3/4 domain; Region: B3_4; pfam03483
335992001483	tRNA synthetase B5 domain; Region: B5; smart00874
335992001484	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
335992001485	dimer interface [polypeptide binding]; other site
335992001486	motif 1; other site
335992001487	motif 3; other site
335992001488	motif 2; other site
335992001489	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
335992001490	GTP-binding protein LepA; Provisional; Region: PRK05433
335992001491	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
335992001492	G1 box; other site
335992001493	putative GEF interaction site [polypeptide binding]; other site
335992001494	GTP/Mg2+ binding site [chemical binding]; other site
335992001495	Switch I region; other site
335992001496	G2 box; other site
335992001497	G3 box; other site
335992001498	Switch II region; other site
335992001499	G4 box; other site
335992001500	G5 box; other site
335992001501	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
335992001502	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
335992001503	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
335992001504	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
335992001505	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
335992001506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335992001507	Mg2+ binding site [ion binding]; other site
335992001508	G-X-G motif; other site
335992001509	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
335992001510	anchoring element; other site
335992001511	dimer interface [polypeptide binding]; other site
335992001512	ATP binding site [chemical binding]; other site
335992001513	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
335992001514	active site
335992001515	metal binding site [ion binding]; metal-binding site
335992001516	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
335992001517	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335992001518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335992001519	Mg2+ binding site [ion binding]; other site
335992001520	G-X-G motif; other site
335992001521	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
335992001522	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
335992001523	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
335992001524	metal ion-dependent adhesion site (MIDAS); other site
335992001525	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
335992001526	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
335992001527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335992001528	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335992001529	HSP70 interaction site [polypeptide binding]; other site
335992001530	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
335992001531	active site
335992001532	dimer interface [polypeptide binding]; other site
335992001533	metal binding site [ion binding]; metal-binding site
335992001534	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
335992001535	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
335992001536	ADP binding site [chemical binding]; other site
335992001537	magnesium binding site [ion binding]; other site
335992001538	putative shikimate binding site; other site
335992001539	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
335992001540	active site
335992001541	catalytic residues [active]
335992001542	metal binding site [ion binding]; metal-binding site
335992001543	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
335992001544	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
335992001545	putative active site [active]
335992001546	substrate binding site [chemical binding]; other site
335992001547	putative cosubstrate binding site; other site
335992001548	catalytic site [active]
335992001549	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
335992001550	substrate binding site [chemical binding]; other site
335992001551	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
335992001552	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
335992001553	dimerization interface 3.5A [polypeptide binding]; other site
335992001554	active site
335992001555	SET domain; Region: SET; pfam00856
335992001556	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
335992001557	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
335992001558	putative active site [active]
335992001559	Zn binding site [ion binding]; other site
335992001560	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
335992001561	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
335992001562	metal binding site [ion binding]; metal-binding site
335992001563	dimer interface [polypeptide binding]; other site
335992001564	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
335992001565	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
335992001566	trimer interface [polypeptide binding]; other site
335992001567	active site
335992001568	substrate binding site [chemical binding]; other site
335992001569	CoA binding site [chemical binding]; other site
335992001570	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
335992001571	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335992001572	motif II; other site
335992001573	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
335992001574	feedback inhibition sensing region; other site
335992001575	homohexameric interface [polypeptide binding]; other site
335992001576	nucleotide binding site [chemical binding]; other site
335992001577	N-acetyl-L-glutamate binding site [chemical binding]; other site
335992001578	membrane protein insertase; Provisional; Region: PRK01318
335992001579	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
335992001580	Haemolytic domain; Region: Haemolytic; pfam01809
335992001581	Ribosomal protein L34; Region: Ribosomal_L34; pfam00468
335992001582	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
335992001583	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
335992001584	trimer interface [polypeptide binding]; other site
335992001585	active site
335992001586	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
335992001587	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
335992001588	hinge; other site
335992001589	active site
335992001590	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
335992001591	histidinol dehydrogenase; Region: hisD; TIGR00069
335992001592	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
335992001593	NAD binding site [chemical binding]; other site
335992001594	dimerization interface [polypeptide binding]; other site
335992001595	product binding site; other site
335992001596	substrate binding site [chemical binding]; other site
335992001597	zinc binding site [ion binding]; other site
335992001598	catalytic residues [active]
335992001599	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
335992001600	rRNA binding site [nucleotide binding]; other site
335992001601	predicted 30S ribosome binding site; other site
335992001602	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335992001603	DNA-binding site [nucleotide binding]; DNA binding site
335992001604	RNA-binding motif; other site
335992001605	histidyl-tRNA synthetase; Region: hisS; TIGR00442
335992001606	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
335992001607	dimer interface [polypeptide binding]; other site
335992001608	motif 1; other site
335992001609	motif 2; other site
335992001610	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335992001611	active site
335992001612	motif 3; other site
335992001613	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
335992001614	anticodon binding site; other site
335992001615	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
335992001616	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335992001617	motif 1; other site
335992001618	dimer interface [polypeptide binding]; other site
335992001619	motif 2; other site
335992001620	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335992001621	motif 3; other site
335992001622	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
335992001623	RmuC family; Region: RmuC; pfam02646
335992001624	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
335992001625	active site
335992001626	catalytic site [active]
335992001627	substrate binding site [chemical binding]; other site
335992001628	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
335992001629	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
335992001630	catalytic residues [active]
335992001631	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
335992001632	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
335992001633	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
335992001634	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
335992001635	substrate binding site [chemical binding]; other site
335992001636	active site
335992001637	catalytic residues [active]
335992001638	heterodimer interface [polypeptide binding]; other site
335992001639	tryptophan synthase subunit beta; Validated; Region: PRK04346
335992001640	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
335992001641	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992001642	catalytic residue [active]
335992001643	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
335992001644	active site
335992001645	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
335992001646	active site
335992001647	dimer interface [polypeptide binding]; other site
335992001648	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335992001649	IHF - DNA interface [nucleotide binding]; other site
335992001650	IHF dimer interface [polypeptide binding]; other site
335992001651	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
335992001652	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
335992001653	RNA binding site [nucleotide binding]; other site
335992001654	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
335992001655	RNA binding site [nucleotide binding]; other site
335992001656	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
335992001657	RNA binding site [nucleotide binding]; other site
335992001658	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
335992001659	RNA binding site [nucleotide binding]; other site
335992001660	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
335992001661	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
335992001662	CMP-binding site; other site
335992001663	The sites determining sugar specificity; other site
335992001664	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
335992001665	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
335992001666	putative active site [active]
335992001667	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
335992001668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335992001669	Walker A/P-loop; other site
335992001670	ATP binding site [chemical binding]; other site
335992001671	Q-loop/lid; other site
335992001672	ABC transporter signature motif; other site
335992001673	Walker B; other site
335992001674	D-loop; other site
335992001675	H-loop/switch region; other site
335992001676	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
335992001677	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
335992001678	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
335992001679	putative active site [active]
335992001680	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
335992001681	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
335992001682	catalytic site [active]
335992001683	putative active site [active]
335992001684	putative substrate binding site [chemical binding]; other site
335992001685	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
335992001686	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
335992001687	putative NAD(P) binding site [chemical binding]; other site
335992001688	active site
335992001689	GcrA cell cycle regulator; Region: GcrA; cl11564
335992001690	ABC-2 type transporter; Region: ABC2_membrane; cl17235
335992001691	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
335992001692	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335992001693	inhibitor-cofactor binding pocket; inhibition site
335992001694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992001695	catalytic residue [active]
335992001696	ornithine carbamoyltransferase; Provisional; Region: PRK00779
335992001697	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
335992001698	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
335992001699	Cytochrome c2 [Energy production and conversion]; Region: COG3474
335992001700	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
335992001701	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335992001702	active site
335992001703	prephenate dehydratase; Provisional; Region: PRK11899
335992001704	Prephenate dehydratase; Region: PDT; pfam00800
335992001705	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
335992001706	putative L-Phe binding site [chemical binding]; other site
335992001707	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
335992001708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992001709	Walker A motif; other site
335992001710	ATP binding site [chemical binding]; other site
335992001711	Walker B motif; other site
335992001712	arginine finger; other site
335992001713	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
335992001714	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
335992001715	hypothetical protein; Validated; Region: PRK00153
335992001716	recombination protein RecR; Reviewed; Region: recR; PRK00076
335992001717	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
335992001718	putative active site [active]
335992001719	putative metal-binding site [ion binding]; other site
335992001720	tetramer interface [polypeptide binding]; other site
335992001721	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
335992001722	active site
335992001723	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
335992001724	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
335992001725	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
335992001726	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
335992001727	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
335992001728	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335992001729	nucleotide binding region [chemical binding]; other site
335992001730	ATP-binding site [chemical binding]; other site
335992001731	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
335992001732	heterotetramer interface [polypeptide binding]; other site
335992001733	active site pocket [active]
335992001734	cleavage site
335992001735	Protein of unknown function (DUF1178); Region: DUF1178; cl17833
335992001736	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
335992001737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992001738	S-adenosylmethionine binding site [chemical binding]; other site
335992001739	aspartate kinase; Reviewed; Region: PRK06635
335992001740	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
335992001741	putative nucleotide binding site [chemical binding]; other site
335992001742	putative catalytic residues [active]
335992001743	putative Mg ion binding site [ion binding]; other site
335992001744	putative aspartate binding site [chemical binding]; other site
335992001745	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
335992001746	putative allosteric regulatory site; other site
335992001747	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
335992001748	putative allosteric regulatory residue; other site
335992001749	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
335992001750	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
335992001751	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
335992001752	peptide chain release factor 1; Validated; Region: prfA; PRK00591
335992001753	This domain is found in peptide chain release factors; Region: PCRF; smart00937
335992001754	RF-1 domain; Region: RF-1; pfam00472
335992001755	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
335992001756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992001757	S-adenosylmethionine binding site [chemical binding]; other site
335992001758	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
335992001759	putative peptidase; Provisional; Region: PRK11649
335992001760	Peptidase family M23; Region: Peptidase_M23; pfam01551
335992001761	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
335992001762	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
335992001763	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335992001764	extended (e) SDRs; Region: SDR_e; cd08946
335992001765	NAD(P) binding site [chemical binding]; other site
335992001766	active site
335992001767	substrate binding site [chemical binding]; other site
335992001768	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001769	NAD(P) binding site [chemical binding]; other site
335992001770	active site
335992001771	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
335992001772	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335992001773	PYR/PP interface [polypeptide binding]; other site
335992001774	dimer interface [polypeptide binding]; other site
335992001775	TPP binding site [chemical binding]; other site
335992001776	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335992001777	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
335992001778	TPP-binding site [chemical binding]; other site
335992001779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335992001780	Methyltransferase domain; Region: Methyltransf_31; pfam13847
335992001781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992001782	S-adenosylmethionine binding site [chemical binding]; other site
335992001783	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
335992001784	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
335992001785	NAD(P) binding site [chemical binding]; other site
335992001786	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
335992001787	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335992001788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335992001789	TrkA-N domain; Region: TrkA_N; pfam02254
335992001790	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
335992001791	classical (c) SDRs; Region: SDR_c; cd05233
335992001792	NAD(P) binding site [chemical binding]; other site
335992001793	active site
335992001794	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335992001795	FAD binding domain; Region: FAD_binding_4; pfam01565
335992001796	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
335992001797	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
335992001798	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335992001799	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992001800	catalytic residue [active]
335992001801	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335992001802	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335992001803	PYR/PP interface [polypeptide binding]; other site
335992001804	dimer interface [polypeptide binding]; other site
335992001805	TPP binding site [chemical binding]; other site
335992001806	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335992001807	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
335992001808	TPP-binding site [chemical binding]; other site
335992001809	dimer interface [polypeptide binding]; other site
335992001810	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335992001811	extended (e) SDRs; Region: SDR_e; cd08946
335992001812	NAD(P) binding site [chemical binding]; other site
335992001813	active site
335992001814	substrate binding site [chemical binding]; other site
335992001815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001816	N-terminal domain of RfaE; Region: RfaE_N; cd02172
335992001817	putative active site [active]
335992001818	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
335992001819	(T/H)XGH motif; other site
335992001820	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335992001821	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
335992001822	substrate binding site [chemical binding]; other site
335992001823	ATP binding site [chemical binding]; other site
335992001824	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
335992001825	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335992001826	active site
335992001827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001828	NAD(P) binding site [chemical binding]; other site
335992001829	active site
335992001830	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
335992001831	active site
335992001832	dimer interface [polypeptide binding]; other site
335992001833	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
335992001834	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335992001835	active site
335992001836	motif I; other site
335992001837	motif II; other site
335992001838	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
335992001839	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992001840	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335992001841	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
335992001842	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
335992001843	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
335992001844	putative metal binding site; other site
335992001845	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
335992001846	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335992001847	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992001848	catalytic residue [active]
335992001849	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
335992001850	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
335992001851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335992001852	S-adenosylmethionine binding site [chemical binding]; other site
335992001853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992001854	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335992001855	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
335992001856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992001857	putative ADP-binding pocket [chemical binding]; other site
335992001858	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335992001859	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992001860	S-adenosylmethionine binding site [chemical binding]; other site
335992001861	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335992001862	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992001863	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335992001864	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
335992001865	metal-binding site
335992001866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001868	O-Antigen ligase; Region: Wzy_C; pfam04932
335992001869	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
335992001870	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
335992001871	Mg++ binding site [ion binding]; other site
335992001872	putative catalytic motif [active]
335992001873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001874	NAD(P) binding site [chemical binding]; other site
335992001875	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
335992001876	active site
335992001877	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
335992001878	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
335992001879	NADP-binding site; other site
335992001880	homotetramer interface [polypeptide binding]; other site
335992001881	substrate binding site [chemical binding]; other site
335992001882	homodimer interface [polypeptide binding]; other site
335992001883	active site
335992001884	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001885	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
335992001886	NAD(P) binding site [chemical binding]; other site
335992001887	active site
335992001888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992001889	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
335992001890	NAD(P) binding site [chemical binding]; other site
335992001891	active site
335992001892	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
335992001893	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
335992001894	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
335992001895	ligand binding site [chemical binding]; other site
335992001896	homodimer interface [polypeptide binding]; other site
335992001897	NAD(P) binding site [chemical binding]; other site
335992001898	trimer interface B [polypeptide binding]; other site
335992001899	trimer interface A [polypeptide binding]; other site
335992001900	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
335992001901	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
335992001902	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
335992001903	putative translaldolase; Provisional; Region: PRK12376
335992001904	catalytic residue [active]
335992001905	Ribosomal protein S21; Region: Ribosomal_S21; pfam01165
335992001906	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
335992001907	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
335992001908	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335992001909	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
335992001910	active site
335992001911	dimerization interface [polypeptide binding]; other site
335992001912	translation elongation factor P; Region: efp; TIGR00038
335992001913	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
335992001914	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
335992001915	RNA binding site [nucleotide binding]; other site
335992001916	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
335992001917	RNA binding site [nucleotide binding]; other site
335992001918	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
335992001919	thiamine phosphate binding site [chemical binding]; other site
335992001920	active site
335992001921	pyrophosphate binding site [ion binding]; other site
335992001922	Class I aldolases; Region: Aldolase_Class_I; cl17187
335992001923	catalytic residue [active]
335992001924	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
335992001925	Phosphoglycerate kinase; Region: PGK; pfam00162
335992001926	substrate binding site [chemical binding]; other site
335992001927	hinge regions; other site
335992001928	ADP binding site [chemical binding]; other site
335992001929	catalytic site [active]
335992001930	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
335992001931	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
335992001932	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
335992001933	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
335992001934	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
335992001935	TPP-binding site [chemical binding]; other site
335992001936	dimer interface [polypeptide binding]; other site
335992001937	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335992001938	PYR/PP interface [polypeptide binding]; other site
335992001939	dimer interface [polypeptide binding]; other site
335992001940	TPP binding site [chemical binding]; other site
335992001941	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335992001942	Cell division protein ZapA; Region: ZapA; pfam05164
335992001943	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
335992001944	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
335992001945	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335992001946	putative active site [active]
335992001947	metal binding site [ion binding]; metal-binding site
335992001948	homodimer binding site [polypeptide binding]; other site
335992001949	hypothetical protein; Validated; Region: PRK00110
335992001950	TolQ protein; Region: tolQ; TIGR02796
335992001951	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
335992001952	TolR protein; Region: tolR; TIGR02801
335992001953	translocation protein TolB; Provisional; Region: tolB; PRK05137
335992001954	TolB amino-terminal domain; Region: TolB_N; pfam04052
335992001955	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335992001956	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335992001957	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335992001958	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335992001959	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
335992001960	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335992001961	ligand binding site [chemical binding]; other site
335992001962	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
335992001963	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
335992001964	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
335992001965	Ligand Binding Site [chemical binding]; other site
335992001966	FtsH Extracellular; Region: FtsH_ext; pfam06480
335992001967	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
335992001968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992001969	Walker A motif; other site
335992001970	ATP binding site [chemical binding]; other site
335992001971	Walker B motif; other site
335992001972	arginine finger; other site
335992001973	Peptidase family M41; Region: Peptidase_M41; pfam01434
335992001974	dihydropteroate synthase; Region: DHPS; TIGR01496
335992001975	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
335992001976	substrate binding pocket [chemical binding]; other site
335992001977	dimer interface [polypeptide binding]; other site
335992001978	inhibitor binding site; inhibition site
335992001979	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
335992001980	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
335992001981	active site
335992001982	substrate binding site [chemical binding]; other site
335992001983	metal binding site [ion binding]; metal-binding site
335992001984	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
335992001985	dimer interface [polypeptide binding]; other site
335992001986	substrate binding site [chemical binding]; other site
335992001987	ATP binding site [chemical binding]; other site
335992001988	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
335992001989	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
335992001990	GDP-binding site [chemical binding]; other site
335992001991	ACT binding site; other site
335992001992	IMP binding site; other site
335992001993	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
335992001994	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335992001995	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335992001996	DNA binding residues [nucleotide binding]
335992001997	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
335992001998	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335992001999	RNA binding surface [nucleotide binding]; other site
335992002000	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
335992002001	active site
335992002002	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
335992002003	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
335992002004	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
335992002005	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
335992002006	substrate binding pocket [chemical binding]; other site
335992002007	chain length determination region; other site
335992002008	substrate-Mg2+ binding site; other site
335992002009	catalytic residues [active]
335992002010	aspartate-rich region 1; other site
335992002011	active site lid residues [active]
335992002012	aspartate-rich region 2; other site
335992002013	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
335992002014	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
335992002015	TPP-binding site; other site
335992002016	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335992002017	PYR/PP interface [polypeptide binding]; other site
335992002018	dimer interface [polypeptide binding]; other site
335992002019	TPP binding site [chemical binding]; other site
335992002020	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335992002021	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
335992002022	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
335992002023	Tetramer interface [polypeptide binding]; other site
335992002024	active site
335992002025	FMN-binding site [chemical binding]; other site
335992002026	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
335992002027	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
335992002028	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
335992002029	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
335992002030	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
335992002031	substrate binding pocket [chemical binding]; other site
335992002032	chain length determination region; other site
335992002033	substrate-Mg2+ binding site; other site
335992002034	catalytic residues [active]
335992002035	aspartate-rich region 1; other site
335992002036	active site lid residues [active]
335992002037	aspartate-rich region 2; other site
335992002038	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
335992002039	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
335992002040	tandem repeat interface [polypeptide binding]; other site
335992002041	oligomer interface [polypeptide binding]; other site
335992002042	active site residues [active]
335992002043	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
335992002044	dimer interface [polypeptide binding]; other site
335992002045	motif 1; other site
335992002046	active site
335992002047	motif 2; other site
335992002048	motif 3; other site
335992002049	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
335992002050	pyruvate phosphate dikinase; Provisional; Region: PRK09279
335992002051	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
335992002052	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
335992002053	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
335992002054	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
335992002055	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
335992002056	dimerization interface [polypeptide binding]; other site
335992002057	active site
335992002058	quinolinate synthetase; Provisional; Region: PRK09375
335992002059	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
335992002060	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
335992002061	dihydroorotase; Validated; Region: PRK09060
335992002062	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
335992002063	active site
335992002064	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
335992002065	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
335992002066	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
335992002067	acyl-activating enzyme (AAE) consensus motif; other site
335992002068	putative AMP binding site [chemical binding]; other site
335992002069	putative active site [active]
335992002070	putative CoA binding site [chemical binding]; other site
335992002071	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036
335992002072	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
335992002073	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
335992002074	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335992002075	catalytic loop [active]
335992002076	iron binding site [ion binding]; other site
335992002077	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
335992002078	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335992002079	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335992002080	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
335992002081	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
335992002082	C-terminal domain interface [polypeptide binding]; other site
335992002083	GSH binding site (G-site) [chemical binding]; other site
335992002084	dimer interface [polypeptide binding]; other site
335992002085	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
335992002086	N-terminal domain interface [polypeptide binding]; other site
335992002087	putative dimer interface [polypeptide binding]; other site
335992002088	active site
335992002089	MOSC domain; Region: MOSC; pfam03473
335992002090	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
335992002091	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
335992002092	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335992002093	active site
335992002094	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
335992002095	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
335992002096	active site
335992002097	DNA binding site [nucleotide binding]
335992002098	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
335992002099	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
335992002100	Catalytic site [active]
335992002101	SOUL heme-binding protein; Region: SOUL; pfam04832
335992002102	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335992002103	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
335992002104	active site
335992002105	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
335992002106	recombinase A; Provisional; Region: recA; PRK09354
335992002107	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
335992002108	hexamer interface [polypeptide binding]; other site
335992002109	Walker A motif; other site
335992002110	ATP binding site [chemical binding]; other site
335992002111	Walker B motif; other site
335992002112	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335992002113	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
335992002114	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
335992002115	motif 1; other site
335992002116	active site
335992002117	motif 2; other site
335992002118	motif 3; other site
335992002119	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
335992002120	isocitrate dehydrogenase; Validated; Region: PRK08299
335992002121	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
335992002122	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
335992002123	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
335992002124	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335992002125	active site
335992002126	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
335992002127	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
335992002128	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
335992002129	guanosine monophosphate reductase, eukaryotic; Region: GMP_reduct_1; TIGR01305
335992002130	active site
335992002131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335992002132	binding surface
335992002133	TPR motif; other site
335992002134	GMP synthase; Reviewed; Region: guaA; PRK00074
335992002135	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
335992002136	AMP/PPi binding site [chemical binding]; other site
335992002137	candidate oxyanion hole; other site
335992002138	catalytic triad [active]
335992002139	potential glutamine specificity residues [chemical binding]; other site
335992002140	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
335992002141	ATP Binding subdomain [chemical binding]; other site
335992002142	Ligand Binding sites [chemical binding]; other site
335992002143	Dimerization subdomain; other site
335992002144	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
335992002145	dimer interface [polypeptide binding]; other site
335992002146	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335992002147	active site
335992002148	metal binding site [ion binding]; metal-binding site
335992002149	glutathione binding site [chemical binding]; other site
335992002150	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
335992002151	active site
335992002152	oligomerization interface [polypeptide binding]; other site
335992002153	metal binding site [ion binding]; metal-binding site
335992002154	Integral membrane protein TerC family; Region: TerC; cl10468
335992002155	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335992002156	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
335992002157	putative ligand binding site [chemical binding]; other site
335992002158	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335992002159	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335992002160	TM-ABC transporter signature motif; other site
335992002161	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335992002162	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335992002163	TM-ABC transporter signature motif; other site
335992002164	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335992002165	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335992002166	Walker A/P-loop; other site
335992002167	ATP binding site [chemical binding]; other site
335992002168	Q-loop/lid; other site
335992002169	ABC transporter signature motif; other site
335992002170	Walker B; other site
335992002171	D-loop; other site
335992002172	H-loop/switch region; other site
335992002173	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335992002174	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335992002175	Walker A/P-loop; other site
335992002176	ATP binding site [chemical binding]; other site
335992002177	Q-loop/lid; other site
335992002178	ABC transporter signature motif; other site
335992002179	Walker B; other site
335992002180	D-loop; other site
335992002181	H-loop/switch region; other site
335992002182	hypothetical protein; Provisional; Region: PRK05463
335992002183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
335992002184	TPR motif; other site
335992002185	binding surface
335992002186	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
335992002187	putative active site [active]
335992002188	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
335992002189	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
335992002190	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
335992002191	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992002192	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
335992002193	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992002194	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
335992002195	lipoyl attachment site [posttranslational modification]; other site
335992002196	glycine dehydrogenase; Provisional; Region: PRK05367
335992002197	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
335992002198	tetramer interface [polypeptide binding]; other site
335992002199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992002200	catalytic residue [active]
335992002201	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
335992002202	tetramer interface [polypeptide binding]; other site
335992002203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992002204	catalytic residue [active]
335992002205	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
335992002206	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335992002207	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
335992002208	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
335992002209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335992002210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992002211	S-adenosylmethionine binding site [chemical binding]; other site
335992002212	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
335992002213	short chain dehydrogenase; Provisional; Region: PRK07024
335992002214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992002215	NAD(P) binding site [chemical binding]; other site
335992002216	active site
335992002217	TspO/MBR family; Region: TspO_MBR; pfam03073
335992002218	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992002219	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335992002220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992002221	hypothetical protein; Validated; Region: PRK00029
335992002222	Uncharacterized conserved protein [Function unknown]; Region: COG0397
335992002223	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
335992002224	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
335992002225	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
335992002226	4Fe-4S binding domain; Region: Fer4; pfam00037
335992002227	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
335992002228	[4Fe-4S] binding site [ion binding]; other site
335992002229	molybdopterin cofactor binding site; other site
335992002230	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
335992002231	molybdopterin cofactor binding site; other site
335992002232	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
335992002233	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
335992002234	SLBB domain; Region: SLBB; pfam10531
335992002235	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
335992002236	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
335992002237	HPP family; Region: HPP; pfam04982
335992002238	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
335992002239	trimerization site [polypeptide binding]; other site
335992002240	active site
335992002241	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
335992002242	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
335992002243	GTP binding site; other site
335992002244	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
335992002245	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
335992002246	dimer interface [polypeptide binding]; other site
335992002247	putative functional site; other site
335992002248	putative MPT binding site; other site
335992002249	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
335992002250	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
335992002251	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
335992002252	active site
335992002253	Amidinotransferase; Region: Amidinotransf; cl12043
335992002254	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
335992002255	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
335992002256	tetramer interface [polypeptide binding]; other site
335992002257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992002258	catalytic residue [active]
335992002259	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
335992002260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
335992002261	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
335992002262	SlyX; Region: SlyX; pfam04102
335992002263	HI0933-like protein; Region: HI0933_like; pfam03486
335992002264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335992002265	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335992002266	putative substrate translocation pore; other site
335992002267	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
335992002268	glutathione synthetase; Provisional; Region: PRK05246
335992002269	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
335992002270	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335992002271	glutamate--cysteine ligase; Region: PLN02611
335992002272	amidophosphoribosyltransferase; Provisional; Region: PRK09123
335992002273	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
335992002274	active site
335992002275	tetramer interface [polypeptide binding]; other site
335992002276	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335992002277	active site
335992002278	Colicin V production protein; Region: Colicin_V; pfam02674
335992002279	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
335992002280	Protein export membrane protein; Region: SecD_SecF; cl14618
335992002281	replicative DNA helicase; Provisional; Region: PRK09165
335992002282	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
335992002283	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
335992002284	Walker A motif; other site
335992002285	ATP binding site [chemical binding]; other site
335992002286	Walker B motif; other site
335992002287	DNA binding loops [nucleotide binding]
335992002288	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
335992002289	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
335992002290	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
335992002291	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
335992002292	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
335992002293	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
335992002294	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
335992002295	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335992002296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992002297	NAD(P) binding site [chemical binding]; other site
335992002298	active site
335992002299	acyl carrier protein; Provisional; Region: acpP; PRK00982
335992002300	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
335992002301	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
335992002302	catalytic site [active]
335992002303	G-X2-G-X-G-K; other site
335992002304	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
335992002305	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
335992002306	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
335992002307	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
335992002308	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
335992002309	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
335992002310	Organic solvent tolerance protein; Region: OstA_C; pfam04453
335992002311	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
335992002312	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
335992002313	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
335992002314	multifunctional aminopeptidase A; Provisional; Region: PRK00913
335992002315	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
335992002316	interface (dimer of trimers) [polypeptide binding]; other site
335992002317	Substrate-binding/catalytic site; other site
335992002318	Zn-binding sites [ion binding]; other site
335992002319	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
335992002320	active site
335992002321	multimer interface [polypeptide binding]; other site
335992002322	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
335992002323	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
335992002324	active site
335992002325	substrate binding site [chemical binding]; other site
335992002326	cosubstrate binding site; other site
335992002327	catalytic site [active]
335992002328	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
335992002329	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
335992002330	dimerization interface [polypeptide binding]; other site
335992002331	putative ATP binding site [chemical binding]; other site
335992002332	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
335992002333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335992002334	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
335992002335	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
335992002336	dimer interface [polypeptide binding]; other site
335992002337	anticodon binding site; other site
335992002338	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335992002339	motif 1; other site
335992002340	dimer interface [polypeptide binding]; other site
335992002341	active site
335992002342	motif 2; other site
335992002343	GAD domain; Region: GAD; pfam02938
335992002344	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335992002345	active site
335992002346	motif 3; other site
335992002347	TSCPD domain; Region: TSCPD; pfam12637
335992002348	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
335992002349	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
335992002350	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
335992002351	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335992002352	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335992002353	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
335992002354	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
335992002355	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335992002356	carboxyltransferase (CT) interaction site; other site
335992002357	biotinylation site [posttranslational modification]; other site
335992002358	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
335992002359	Dehydroquinase class II; Region: DHquinase_II; pfam01220
335992002360	active site
335992002361	trimer interface [polypeptide binding]; other site
335992002362	dimer interface [polypeptide binding]; other site
335992002363	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
335992002364	thiS-thiF/thiG interaction site; other site
335992002365	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
335992002366	ThiS interaction site; other site
335992002367	putative active site [active]
335992002368	tetramer interface [polypeptide binding]; other site
335992002369	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
335992002370	RNA binding site [nucleotide binding]; other site
335992002371	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
335992002372	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
335992002373	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
335992002374	Transglycosylase; Region: Transgly; pfam00912
335992002375	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
335992002376	PCRF domain; Region: PCRF; pfam03462
335992002377	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
335992002378	RF-1 domain; Region: RF-1; pfam00472
335992002379	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
335992002380	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
335992002381	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
335992002382	active site
335992002383	HIGH motif; other site
335992002384	dimer interface [polypeptide binding]; other site
335992002385	KMSKS motif; other site
335992002386	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335992002387	RNA binding surface [nucleotide binding]; other site
335992002388	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
335992002389	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
335992002390	Predicted transcriptional regulator [Transcription]; Region: COG1959
335992002391	Transcriptional regulator; Region: Rrf2; cl17282
335992002392	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
335992002393	putative ABC transporter; Region: ycf24; CHL00085
335992002394	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
335992002395	FeS assembly ATPase SufC; Region: sufC; TIGR01978
335992002396	Walker A/P-loop; other site
335992002397	ATP binding site [chemical binding]; other site
335992002398	Q-loop/lid; other site
335992002399	ABC transporter signature motif; other site
335992002400	Walker B; other site
335992002401	D-loop; other site
335992002402	H-loop/switch region; other site
335992002403	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
335992002404	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
335992002405	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
335992002406	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
335992002407	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992002408	catalytic residue [active]
335992002409	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
335992002410	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
335992002411	trimerization site [polypeptide binding]; other site
335992002412	active site
335992002413	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
335992002414	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
335992002415	glutamine synthetase; Provisional; Region: glnA; PRK09469
335992002416	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
335992002417	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
335992002418	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
335992002419	putative deacylase active site [active]
335992002420	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992002421	EamA-like transporter family; Region: EamA; pfam00892
335992002422	EamA-like transporter family; Region: EamA; pfam00892
335992002423	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
335992002424	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
335992002425	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
335992002426	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335992002427	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
335992002428	MPT binding site; other site
335992002429	trimer interface [polypeptide binding]; other site
335992002430	Protein of unknown function (DUF1244); Region: DUF1244; cl01385
335992002431	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
335992002432	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992002433	NAD(P) binding site [chemical binding]; other site
335992002434	catalytic residues [active]
335992002435	Protein of unknown function (DUF779); Region: DUF779; pfam05610
335992002436	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
335992002437	TMAO/DMSO reductase; Reviewed; Region: PRK05363
335992002438	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
335992002439	Moco binding site; other site
335992002440	metal coordination site [ion binding]; other site
335992002441	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
335992002442	MoaE homodimer interface [polypeptide binding]; other site
335992002443	MoaD interaction [polypeptide binding]; other site
335992002444	active site residues [active]
335992002445	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
335992002446	trimer interface [polypeptide binding]; other site
335992002447	dimer interface [polypeptide binding]; other site
335992002448	putative active site [active]
335992002449	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
335992002450	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335992002451	FeS/SAM binding site; other site
335992002452	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
335992002453	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
335992002454	GYD domain; Region: GYD; pfam08734
335992002455	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992002456	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
335992002457	tetramerization interface [polypeptide binding]; other site
335992002458	NAD(P) binding site [chemical binding]; other site
335992002459	catalytic residues [active]
335992002460	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335992002461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992002462	NAD(P) binding site [chemical binding]; other site
335992002463	active site
335992002464	fructokinase; Reviewed; Region: PRK09557
335992002465	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
335992002466	nucleotide binding site [chemical binding]; other site
335992002467	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335992002468	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335992002469	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
335992002470	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335992002471	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335992002472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992002473	dimer interface [polypeptide binding]; other site
335992002474	conserved gate region; other site
335992002475	putative PBP binding loops; other site
335992002476	ABC-ATPase subunit interface; other site
335992002477	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
335992002478	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
335992002479	Walker A/P-loop; other site
335992002480	ATP binding site [chemical binding]; other site
335992002481	Q-loop/lid; other site
335992002482	ABC transporter signature motif; other site
335992002483	Walker B; other site
335992002484	D-loop; other site
335992002485	H-loop/switch region; other site
335992002486	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335992002487	classical (c) SDRs; Region: SDR_c; cd05233
335992002488	NAD(P) binding site [chemical binding]; other site
335992002489	active site
335992002490	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
335992002491	short chain dehydrogenase; Provisional; Region: PRK06138
335992002492	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
335992002493	NAD binding site [chemical binding]; other site
335992002494	homotetramer interface [polypeptide binding]; other site
335992002495	homodimer interface [polypeptide binding]; other site
335992002496	active site
335992002497	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335992002498	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335992002499	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335992002500	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335992002501	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335992002502	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335992002503	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335992002504	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
335992002505	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
335992002506	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
335992002507	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
335992002508	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
335992002509	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335992002510	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335992002511	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
335992002512	active site
335992002513	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
335992002514	Protein of unknown function (DUF952); Region: DUF952; pfam06108
335992002515	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
335992002516	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
335992002517	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
335992002518	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
335992002519	dimer interface [polypeptide binding]; other site
335992002520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992002521	catalytic residue [active]
335992002522	serine O-acetyltransferase; Region: cysE; TIGR01172
335992002523	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
335992002524	trimer interface [polypeptide binding]; other site
335992002525	active site
335992002526	substrate binding site [chemical binding]; other site
335992002527	CoA binding site [chemical binding]; other site
335992002528	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
335992002529	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335992002530	putative metal binding site [ion binding]; other site
335992002531	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
335992002532	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992002533	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
335992002534	NAD(P) binding site [chemical binding]; other site
335992002535	catalytic residues [active]
335992002536	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
335992002537	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
335992002538	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
335992002539	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
335992002540	Walker A/P-loop; other site
335992002541	ATP binding site [chemical binding]; other site
335992002542	Q-loop/lid; other site
335992002543	ABC transporter signature motif; other site
335992002544	Walker B; other site
335992002545	D-loop; other site
335992002546	H-loop/switch region; other site
335992002547	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992002548	dimer interface [polypeptide binding]; other site
335992002549	conserved gate region; other site
335992002550	putative PBP binding loops; other site
335992002551	ABC-ATPase subunit interface; other site
335992002552	LysE type translocator; Region: LysE; cl00565
335992002553	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
335992002554	histidinol dehydrogenase; Region: hisD; TIGR00069
335992002555	NAD binding site [chemical binding]; other site
335992002556	dimerization interface [polypeptide binding]; other site
335992002557	product binding site; other site
335992002558	substrate binding site [chemical binding]; other site
335992002559	zinc binding site [ion binding]; other site
335992002560	catalytic residues [active]
335992002561	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
335992002562	Epoxide hydrolase N terminus; Region: EHN; pfam06441
335992002563	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335992002564	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
335992002565	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335992002566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992002567	dimer interface [polypeptide binding]; other site
335992002568	conserved gate region; other site
335992002569	putative PBP binding loops; other site
335992002570	ABC-ATPase subunit interface; other site
335992002571	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335992002572	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335992002573	Walker A/P-loop; other site
335992002574	ATP binding site [chemical binding]; other site
335992002575	Q-loop/lid; other site
335992002576	ABC transporter signature motif; other site
335992002577	Walker B; other site
335992002578	D-loop; other site
335992002579	H-loop/switch region; other site
335992002580	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335992002581	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335992002582	substrate binding pocket [chemical binding]; other site
335992002583	membrane-bound complex binding site; other site
335992002584	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
335992002585	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335992002586	inhibitor-cofactor binding pocket; inhibition site
335992002587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992002588	catalytic residue [active]
335992002589	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
335992002590	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
335992002591	hexamer interface [polypeptide binding]; other site
335992002592	ligand binding site [chemical binding]; other site
335992002593	putative active site [active]
335992002594	NAD(P) binding site [chemical binding]; other site
335992002595	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
335992002596	Na binding site [ion binding]; other site
335992002597	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
335992002598	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335992002599	Walker A/P-loop; other site
335992002600	ATP binding site [chemical binding]; other site
335992002601	Q-loop/lid; other site
335992002602	ABC transporter signature motif; other site
335992002603	Walker B; other site
335992002604	D-loop; other site
335992002605	H-loop/switch region; other site
335992002606	ABC-2 type transporter; Region: ABC2_membrane; cl17235
335992002607	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335992002608	active site clefts [active]
335992002609	zinc binding site [ion binding]; other site
335992002610	dimer interface [polypeptide binding]; other site
335992002611	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
335992002612	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
335992002613	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
335992002614	active site
335992002615	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
335992002616	protein binding site [polypeptide binding]; other site
335992002617	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
335992002618	putative substrate binding region [chemical binding]; other site
335992002619	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335992002620	IHF - DNA interface [nucleotide binding]; other site
335992002621	IHF dimer interface [polypeptide binding]; other site
335992002622	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
335992002623	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
335992002624	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
335992002625	catalytic triad [active]
335992002626	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
335992002627	active site residue [active]
335992002628	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
335992002629	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
335992002630	putative catalytic residue [active]
335992002631	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
335992002632	recombination regulator RecX; Reviewed; Region: recX; PRK00117
335992002633	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
335992002634	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335992002635	active site
335992002636	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
335992002637	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
335992002638	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
335992002639	Ligand Binding Site [chemical binding]; other site
335992002640	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
335992002641	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335992002642	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992002643	catalytic residue [active]
335992002644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335992002645	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335992002646	putative substrate translocation pore; other site
335992002647	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
335992002648	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
335992002649	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
335992002650	Glutamine amidotransferase class-I; Region: GATase; pfam00117
335992002651	glutamine binding [chemical binding]; other site
335992002652	catalytic triad [active]
335992002653	Aminotransferase class IV; Region: Aminotran_4; pfam01063
335992002654	substrate-cofactor binding pocket; other site
335992002655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992002656	catalytic residue [active]
335992002657	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
335992002658	nucleotide binding site/active site [active]
335992002659	HIT family signature motif; other site
335992002660	catalytic residue [active]
335992002661	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
335992002662	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
335992002663	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
335992002664	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
335992002665	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
335992002666	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335992002667	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
335992002668	Predicted membrane protein [Function unknown]; Region: COG2855
335992002669	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
335992002670	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
335992002671	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
335992002672	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335992002673	PYR/PP interface [polypeptide binding]; other site
335992002674	dimer interface [polypeptide binding]; other site
335992002675	TPP binding site [chemical binding]; other site
335992002676	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335992002677	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
335992002678	TPP-binding site; other site
335992002679	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335992002680	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
335992002681	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335992002682	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992002683	NAD(P) binding site [chemical binding]; other site
335992002684	active site
335992002685	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335992002686	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992002687	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
335992002688	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
335992002689	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
335992002690	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335992002691	Walker A/P-loop; other site
335992002692	ATP binding site [chemical binding]; other site
335992002693	Q-loop/lid; other site
335992002694	ABC transporter signature motif; other site
335992002695	Walker B; other site
335992002696	D-loop; other site
335992002697	H-loop/switch region; other site
335992002698	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
335992002699	active site
335992002700	catalytic triad [active]
335992002701	oxyanion hole [active]
335992002702	switch loop; other site
335992002703	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
335992002704	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335992002705	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
335992002706	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
335992002707	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
335992002708	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
335992002709	active site
335992002710	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
335992002711	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
335992002712	Peptidase family M23; Region: Peptidase_M23; pfam01551
335992002713	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335992002714	classical (c) SDRs; Region: SDR_c; cd05233
335992002715	NAD(P) binding site [chemical binding]; other site
335992002716	active site
335992002717	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
335992002718	choline dehydrogenase; Validated; Region: PRK02106
335992002719	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335992002720	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
335992002721	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
335992002722	active site residue [active]
335992002723	Predicted transcriptional regulators [Transcription]; Region: COG1733
335992002724	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335992002725	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335992002726	classical (c) SDRs; Region: SDR_c; cd05233
335992002727	NAD(P) binding site [chemical binding]; other site
335992002728	active site
335992002729	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992002730	Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108
335992002731	NAD(P) binding site [chemical binding]; other site
335992002732	catalytic residues [active]
335992002733	catalytic residues [active]
335992002734	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335992002735	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
335992002736	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335992002737	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335992002738	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
335992002739	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
335992002740	DctM-like transporters; Region: DctM; pfam06808
335992002741	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992002742	EamA-like transporter family; Region: EamA; pfam00892
335992002743	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
335992002744	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
335992002745	Na binding site [ion binding]; other site
335992002746	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335992002747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335992002748	NAD(P) binding site [chemical binding]; other site
335992002749	active site
335992002750	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
335992002751	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
335992002752	active site
335992002753	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
335992002754	Fe-S cluster binding site [ion binding]; other site
335992002755	DNA binding site [nucleotide binding]
335992002756	active site
335992002757	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
335992002758	catalytic core [active]
335992002759	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
335992002760	trigger factor; Provisional; Region: tig; PRK01490
335992002761	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
335992002762	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
335992002763	Clp protease; Region: CLP_protease; pfam00574
335992002764	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
335992002765	oligomer interface [polypeptide binding]; other site
335992002766	active site residues [active]
335992002767	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
335992002768	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
335992002769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992002770	Walker A motif; other site
335992002771	ATP binding site [chemical binding]; other site
335992002772	Walker B motif; other site
335992002773	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
335992002774	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
335992002775	Found in ATP-dependent protease La (LON); Region: LON; smart00464
335992002776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992002777	Walker A motif; other site
335992002778	ATP binding site [chemical binding]; other site
335992002779	Walker B motif; other site
335992002780	arginine finger; other site
335992002781	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
335992002782	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
335992002783	NADH dehydrogenase subunit B; Validated; Region: PRK06411
335992002784	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
335992002785	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
335992002786	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
335992002787	NADH dehydrogenase subunit D; Validated; Region: PRK06075
335992002788	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
335992002789	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
335992002790	putative dimer interface [polypeptide binding]; other site
335992002791	[2Fe-2S] cluster binding site [ion binding]; other site
335992002792	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
335992002793	SLBB domain; Region: SLBB; pfam10531
335992002794	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
335992002795	NADH dehydrogenase subunit G; Validated; Region: PRK09130
335992002796	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335992002797	catalytic loop [active]
335992002798	iron binding site [ion binding]; other site
335992002799	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
335992002800	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
335992002801	molybdopterin cofactor binding site; other site
335992002802	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
335992002803	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
335992002804	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
335992002805	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
335992002806	4Fe-4S binding domain; Region: Fer4; pfam00037
335992002807	4Fe-4S binding domain; Region: Fer4; pfam00037
335992002808	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
335992002809	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
335992002810	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
335992002811	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
335992002812	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
335992002813	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
335992002814	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
335992002815	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
335992002816	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
335992002817	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
335992002818	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
335992002819	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
335992002820	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
335992002821	Type III pantothenate kinase; Region: Pan_kinase; cl17198
335992002822	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
335992002823	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335992002824	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
335992002825	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
335992002826	prolyl-tRNA synthetase; Provisional; Region: PRK12325
335992002827	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
335992002828	dimer interface [polypeptide binding]; other site
335992002829	motif 1; other site
335992002830	active site
335992002831	motif 2; other site
335992002832	motif 3; other site
335992002833	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
335992002834	anticodon binding site; other site
335992002835	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
335992002836	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
335992002837	FtsX-like permease family; Region: FtsX; pfam02687
335992002838	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335992002839	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
335992002840	Walker A/P-loop; other site
335992002841	ATP binding site [chemical binding]; other site
335992002842	Q-loop/lid; other site
335992002843	ABC transporter signature motif; other site
335992002844	Walker B; other site
335992002845	D-loop; other site
335992002846	H-loop/switch region; other site
335992002847	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
335992002848	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
335992002849	putative active site [active]
335992002850	putative PHP Thumb interface [polypeptide binding]; other site
335992002851	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
335992002852	generic binding surface I; other site
335992002853	generic binding surface II; other site
335992002854	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
335992002855	rRNA interaction site [nucleotide binding]; other site
335992002856	S8 interaction site; other site
335992002857	putative laminin-1 binding site; other site
335992002858	elongation factor Ts; Provisional; Region: tsf; PRK09377
335992002859	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
335992002860	Elongation factor TS; Region: EF_TS; pfam00889
335992002861	Elongation factor TS; Region: EF_TS; pfam00889
335992002862	ribosome recycling factor; Reviewed; Region: frr; PRK00083
335992002863	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
335992002864	hinge region; other site
335992002865	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
335992002866	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
335992002867	catalytic residue [active]
335992002868	putative FPP diphosphate  binding site; other site
335992002869	putative FPP binding hydrophobic cleft; other site
335992002870	dimer interface [polypeptide binding]; other site
335992002871	putative IPP diphosphate binding site; other site
335992002872	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
335992002873	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
335992002874	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
335992002875	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
335992002876	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
335992002877	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
335992002878	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
335992002879	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
335992002880	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335992002881	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335992002882	Surface antigen; Region: Bac_surface_Ag; pfam01103
335992002883	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
335992002884	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
335992002885	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
335992002886	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
335992002887	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
335992002888	trimer interface [polypeptide binding]; other site
335992002889	active site
335992002890	UDP-GlcNAc binding site [chemical binding]; other site
335992002891	lipid binding site [chemical binding]; lipid-binding site
335992002892	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
335992002893	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
335992002894	active site
335992002895	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
335992002896	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
335992002897	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
335992002898	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
335992002899	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992002900	active site
335992002901	HIGH motif; other site
335992002902	nucleotide binding site [chemical binding]; other site
335992002903	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
335992002904	active site
335992002905	KMSKS motif; other site
335992002906	LexA repressor; Validated; Region: PRK00215
335992002907	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
335992002908	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
335992002909	Catalytic site [active]
335992002910	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
335992002911	active site
335992002912	ribulose/triose binding site [chemical binding]; other site
335992002913	phosphate binding site [ion binding]; other site
335992002914	substrate (anthranilate) binding pocket [chemical binding]; other site
335992002915	product (indole) binding pocket [chemical binding]; other site
335992002916	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
335992002917	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
335992002918	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
335992002919	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
335992002920	Glutamine amidotransferase class-I; Region: GATase; pfam00117
335992002921	glutamine binding [chemical binding]; other site
335992002922	catalytic triad [active]
335992002923	anthranilate synthase component I; Provisional; Region: PRK13573
335992002924	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
335992002925	SurA N-terminal domain; Region: SurA_N_3; cl07813
335992002926	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
335992002927	triosephosphate isomerase; Provisional; Region: PRK14565
335992002928	substrate binding site [chemical binding]; other site
335992002929	dimer interface [polypeptide binding]; other site
335992002930	catalytic triad [active]
335992002931	Preprotein translocase SecG subunit; Region: SecG; pfam03840
335992002932	Outer membrane efflux protein; Region: OEP; pfam02321
335992002933	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
335992002934	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
335992002935	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002936	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002937	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002938	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002939	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002940	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002941	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002942	VCBS repeat; Region: VCBS_repeat; TIGR01965
335992002943	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335992002944	HlyD family secretion protein; Region: HlyD_3; pfam13437
335992002945	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
335992002946	HlyD family secretion protein; Region: HlyD_3; pfam13437
335992002947	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
335992002948	Peptidase family M50; Region: Peptidase_M50; pfam02163
335992002949	active site
335992002950	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
335992002951	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
335992002952	lipoyl-biotinyl attachment site [posttranslational modification]; other site
335992002953	CTP synthetase; Validated; Region: pyrG; PRK05380
335992002954	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
335992002955	Catalytic site [active]
335992002956	active site
335992002957	UTP binding site [chemical binding]; other site
335992002958	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
335992002959	active site
335992002960	putative oxyanion hole; other site
335992002961	catalytic triad [active]
335992002962	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
335992002963	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
335992002964	enolase; Provisional; Region: eno; PRK00077
335992002965	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
335992002966	dimer interface [polypeptide binding]; other site
335992002967	metal binding site [ion binding]; metal-binding site
335992002968	substrate binding pocket [chemical binding]; other site
335992002969	Septum formation initiator; Region: DivIC; pfam04977
335992002970	lipoyl synthase; Provisional; Region: PRK05481
335992002971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335992002972	FeS/SAM binding site; other site
335992002973	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
335992002974	putative coenzyme Q binding site [chemical binding]; other site
335992002975	Competence-damaged protein; Region: CinA; pfam02464
335992002976	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
335992002977	tetramer interfaces [polypeptide binding]; other site
335992002978	binuclear metal-binding site [ion binding]; other site
335992002979	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
335992002980	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
335992002981	substrate binding site; other site
335992002982	dimer interface; other site
335992002983	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
335992002984	homotrimer interaction site [polypeptide binding]; other site
335992002985	zinc binding site [ion binding]; other site
335992002986	CDP-binding sites; other site
335992002987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335992002988	dimer interface [polypeptide binding]; other site
335992002989	phosphorylation site [posttranslational modification]
335992002990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335992002991	ATP binding site [chemical binding]; other site
335992002992	G-X-G motif; other site
335992002993	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
335992002994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335992002995	active site
335992002996	phosphorylation site [posttranslational modification]
335992002997	intermolecular recognition site; other site
335992002998	dimerization interface [polypeptide binding]; other site
335992002999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335992003000	Walker A motif; other site
335992003001	ATP binding site [chemical binding]; other site
335992003002	Walker B motif; other site
335992003003	arginine finger; other site
335992003004	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335992003005	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
335992003006	TrkA-N domain; Region: TrkA_N; pfam02254
335992003007	TrkA-C domain; Region: TrkA_C; pfam02080
335992003008	TrkA-N domain; Region: TrkA_N; pfam02254
335992003009	TrkA-C domain; Region: TrkA_C; pfam02080
335992003010	Cation transport protein; Region: TrkH; cl17365
335992003011	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
335992003012	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335992003013	substrate binding pocket [chemical binding]; other site
335992003014	membrane-bound complex binding site; other site
335992003015	hinge residues; other site
335992003016	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
335992003017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335992003018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003019	dimer interface [polypeptide binding]; other site
335992003020	ABC-ATPase subunit interface; other site
335992003021	putative PBP binding loops; other site
335992003022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003023	dimer interface [polypeptide binding]; other site
335992003024	conserved gate region; other site
335992003025	putative PBP binding loops; other site
335992003026	ABC-ATPase subunit interface; other site
335992003027	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335992003028	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335992003029	Walker A/P-loop; other site
335992003030	ATP binding site [chemical binding]; other site
335992003031	Q-loop/lid; other site
335992003032	ABC transporter signature motif; other site
335992003033	Walker B; other site
335992003034	D-loop; other site
335992003035	H-loop/switch region; other site
335992003036	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335992003037	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335992003038	non-specific DNA binding site [nucleotide binding]; other site
335992003039	salt bridge; other site
335992003040	sequence-specific DNA binding site [nucleotide binding]; other site
335992003041	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
335992003042	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
335992003043	HIGH motif; other site
335992003044	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
335992003045	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
335992003046	active site
335992003047	KMSKS motif; other site
335992003048	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
335992003049	tRNA binding surface [nucleotide binding]; other site
335992003050	anticodon binding site; other site
335992003051	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
335992003052	6-phosphogluconate dehydratase; Region: edd; TIGR01196
335992003053	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
335992003054	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
335992003055	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
335992003056	Substrate binding site; other site
335992003057	Cupin domain; Region: Cupin_2; cl17218
335992003058	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
335992003059	metal binding site 2 [ion binding]; metal-binding site
335992003060	putative DNA binding helix; other site
335992003061	metal binding site 1 [ion binding]; metal-binding site
335992003062	dimer interface [polypeptide binding]; other site
335992003063	structural Zn2+ binding site [ion binding]; other site
335992003064	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
335992003065	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
335992003066	putative catalytic site [active]
335992003067	putative phosphate binding site [ion binding]; other site
335992003068	active site
335992003069	metal binding site A [ion binding]; metal-binding site
335992003070	DNA binding site [nucleotide binding]
335992003071	putative AP binding site [nucleotide binding]; other site
335992003072	putative metal binding site B [ion binding]; other site
335992003073	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
335992003074	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
335992003075	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335992003076	Zn2+ binding site [ion binding]; other site
335992003077	Mg2+ binding site [ion binding]; other site
335992003078	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
335992003079	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
335992003080	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
335992003081	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
335992003082	active site
335992003083	HIGH motif; other site
335992003084	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992003085	KMSK motif region; other site
335992003086	tRNA binding surface [nucleotide binding]; other site
335992003087	DALR anticodon binding domain; Region: DALR_1; smart00836
335992003088	anticodon binding site; other site
335992003089	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
335992003090	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
335992003091	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
335992003092	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
335992003093	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
335992003094	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
335992003095	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
335992003096	seryl-tRNA synthetase; Provisional; Region: PRK05431
335992003097	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
335992003098	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
335992003099	dimer interface [polypeptide binding]; other site
335992003100	active site
335992003101	motif 1; other site
335992003102	motif 2; other site
335992003103	motif 3; other site
335992003104	Preprotein translocase subunit; Region: YajC; pfam02699
335992003105	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
335992003106	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
335992003107	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
335992003108	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
335992003109	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
335992003110	Protein export membrane protein; Region: SecD_SecF; pfam02355
335992003111	Predicted membrane protein [Function unknown]; Region: COG3748
335992003112	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
335992003113	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
335992003114	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
335992003115	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
335992003116	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
335992003117	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
335992003118	dimer interface [polypeptide binding]; other site
335992003119	ssDNA binding site [nucleotide binding]; other site
335992003120	tetramer (dimer of dimers) interface [polypeptide binding]; other site
335992003121	DNA gyrase subunit A; Validated; Region: PRK05560
335992003122	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
335992003123	CAP-like domain; other site
335992003124	active site
335992003125	primary dimer interface [polypeptide binding]; other site
335992003126	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335992003127	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335992003128	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335992003129	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335992003130	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
335992003131	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
335992003132	active site
335992003133	(T/H)XGH motif; other site
335992003134	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
335992003135	active site
335992003136	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
335992003137	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
335992003138	Peptidase family M48; Region: Peptidase_M48; pfam01435
335992003139	Uncharacterized conserved protein [Function unknown]; Region: COG2928
335992003140	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
335992003141	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
335992003142	generic binding surface II; other site
335992003143	ssDNA binding site; other site
335992003144	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335992003145	ATP binding site [chemical binding]; other site
335992003146	putative Mg++ binding site [ion binding]; other site
335992003147	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335992003148	nucleotide binding region [chemical binding]; other site
335992003149	ATP-binding site [chemical binding]; other site
335992003150	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
335992003151	Predicted permeases [General function prediction only]; Region: RarD; COG2962
335992003152	Transglycosylase SLT domain; Region: SLT_2; pfam13406
335992003153	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335992003154	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335992003155	rare lipoprotein A; Region: rlpA; TIGR00413
335992003156	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
335992003157	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
335992003158	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
335992003159	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
335992003160	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
335992003161	TMP-binding site; other site
335992003162	ATP-binding site [chemical binding]; other site
335992003163	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
335992003164	DNA polymerase III subunit delta'; Validated; Region: PRK08485
335992003165	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
335992003166	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
335992003167	active site
335992003168	HIGH motif; other site
335992003169	KMSKS motif; other site
335992003170	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
335992003171	tRNA binding surface [nucleotide binding]; other site
335992003172	anticodon binding site; other site
335992003173	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
335992003174	active site
335992003175	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
335992003176	putative hydrolase; Provisional; Region: PRK02113
335992003177	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
335992003178	catalytic residues [active]
335992003179	dimer interface [polypeptide binding]; other site
335992003180	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
335992003181	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
335992003182	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
335992003183	SbmA/BacA-like family; Region: SbmA_BacA; pfam05992
335992003184	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
335992003185	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
335992003186	putative active site [active]
335992003187	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
335992003188	DHH family; Region: DHH; pfam01368
335992003189	DHHA1 domain; Region: DHHA1; pfam02272
335992003190	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
335992003191	GIY-YIG motif/motif A; other site
335992003192	putative active site [active]
335992003193	putative metal binding site [ion binding]; other site
335992003194	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335992003195	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992003196	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
335992003197	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335992003198	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
335992003199	putative active site [active]
335992003200	putative metal binding site [ion binding]; other site
335992003201	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335992003202	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
335992003203	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992003204	catalytic residue [active]
335992003205	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
335992003206	extended (e) SDRs; Region: SDR_e; cd08946
335992003207	NAD(P) binding site [chemical binding]; other site
335992003208	active site
335992003209	substrate binding site [chemical binding]; other site
335992003210	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
335992003211	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335992003212	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
335992003213	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
335992003214	DNA binding site [nucleotide binding]
335992003215	dimer interface [polypeptide binding]; other site
335992003216	active site
335992003217	Int/Topo IB signature motif; other site
335992003218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335992003219	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
335992003220	Coenzyme A binding pocket [chemical binding]; other site
335992003221	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
335992003222	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
335992003223	DNA binding site [nucleotide binding]
335992003224	active site
335992003225	EamA-like transporter family; Region: EamA; pfam00892
335992003226	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
335992003227	Predicted permeases [General function prediction only]; Region: COG0679
335992003228	homoserine dehydrogenase; Provisional; Region: PRK06349
335992003229	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
335992003230	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
335992003231	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
335992003232	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
335992003233	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
335992003234	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
335992003235	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
335992003236	23S rRNA interface [nucleotide binding]; other site
335992003237	L3 interface [polypeptide binding]; other site
335992003238	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
335992003239	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335992003240	homodimer interface [polypeptide binding]; other site
335992003241	substrate-cofactor binding pocket; other site
335992003242	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335992003243	catalytic residue [active]
335992003244	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
335992003245	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
335992003246	Chorismate mutase type II; Region: CM_2; smart00830
335992003247	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
335992003248	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
335992003249	DNA binding residues [nucleotide binding]
335992003250	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335992003251	IHF dimer interface [polypeptide binding]; other site
335992003252	IHF - DNA interface [nucleotide binding]; other site
335992003253	putative phosphate acyltransferase; Provisional; Region: PRK05331
335992003254	ribosomal protein L32; Region: rpmF_bact; TIGR01031
335992003255	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
335992003256	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
335992003257	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
335992003258	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
335992003259	thiamine monophosphate kinase; Provisional; Region: PRK05731
335992003260	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
335992003261	ATP binding site [chemical binding]; other site
335992003262	dimerization interface [polypeptide binding]; other site
335992003263	transcription antitermination factor NusB; Region: nusB; TIGR01951
335992003264	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
335992003265	homopentamer interface [polypeptide binding]; other site
335992003266	active site
335992003267	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
335992003268	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
335992003269	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
335992003270	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
335992003271	Lumazine binding domain; Region: Lum_binding; pfam00677
335992003272	Lumazine binding domain; Region: Lum_binding; pfam00677
335992003273	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
335992003274	catalytic motif [active]
335992003275	Zn binding site [ion binding]; other site
335992003276	RibD C-terminal domain; Region: RibD_C; cl17279
335992003277	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
335992003278	ATP cone domain; Region: ATP-cone; pfam03477
335992003279	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
335992003280	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
335992003281	dimer interface [polypeptide binding]; other site
335992003282	active site
335992003283	glycine-pyridoxal phosphate binding site [chemical binding]; other site
335992003284	folate binding site [chemical binding]; other site
335992003285	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
335992003286	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
335992003287	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
335992003288	dimer interface [polypeptide binding]; other site
335992003289	allosteric magnesium binding site [ion binding]; other site
335992003290	active site
335992003291	aspartate-rich active site metal binding site; other site
335992003292	Schiff base residues; other site
335992003293	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
335992003294	Recombination protein O N terminal; Region: RecO_N; pfam11967
335992003295	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
335992003296	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
335992003297	dimerization interface [polypeptide binding]; other site
335992003298	active site
335992003299	metal binding site [ion binding]; metal-binding site
335992003300	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
335992003301	dsRNA binding site [nucleotide binding]; other site
335992003302	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
335992003303	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335992003304	Catalytic site [active]
335992003305	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335992003306	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
335992003307	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
335992003308	active site
335992003309	hydrophilic channel; other site
335992003310	dimerization interface [polypeptide binding]; other site
335992003311	catalytic residues [active]
335992003312	active site lid [active]
335992003313	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335992003314	active site
335992003315	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
335992003316	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335992003317	Zn2+ binding site [ion binding]; other site
335992003318	Mg2+ binding site [ion binding]; other site
335992003319	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
335992003320	synthetase active site [active]
335992003321	NTP binding site [chemical binding]; other site
335992003322	metal binding site [ion binding]; metal-binding site
335992003323	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
335992003324	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
335992003325	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
335992003326	catalytic center binding site [active]
335992003327	ATP binding site [chemical binding]; other site
335992003328	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
335992003329	SmpB-tmRNA interface; other site
335992003330	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335992003331	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
335992003332	dimer interface [polypeptide binding]; other site
335992003333	active site
335992003334	catalytic residue [active]
335992003335	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
335992003336	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335992003337	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335992003338	catalytic residue [active]
335992003339	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
335992003340	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335992003341	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
335992003342	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
335992003343	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
335992003344	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
335992003345	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992003346	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
335992003347	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335992003348	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335992003349	substrate binding pocket [chemical binding]; other site
335992003350	membrane-bound complex binding site; other site
335992003351	hinge residues; other site
335992003352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003353	dimer interface [polypeptide binding]; other site
335992003354	conserved gate region; other site
335992003355	putative PBP binding loops; other site
335992003356	ABC-ATPase subunit interface; other site
335992003357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335992003358	Coenzyme A binding pocket [chemical binding]; other site
335992003359	Staphylococcal nuclease homologues; Region: SNc; smart00318
335992003360	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
335992003361	Catalytic site; other site
335992003362	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
335992003363	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145
335992003364	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
335992003365	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
335992003366	active site residue [active]
335992003367	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
335992003368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992003369	S-adenosylmethionine binding site [chemical binding]; other site
335992003370	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
335992003371	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
335992003372	GatB domain; Region: GatB_Yqey; smart00845
335992003373	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335992003374	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
335992003375	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
335992003376	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
335992003377	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
335992003378	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
335992003379	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
335992003380	dihydroorotase; Validated; Region: PRK09059
335992003381	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335992003382	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
335992003383	active site
335992003384	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
335992003385	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
335992003386	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
335992003387	active site
335992003388	interdomain interaction site; other site
335992003389	putative metal-binding site [ion binding]; other site
335992003390	nucleotide binding site [chemical binding]; other site
335992003391	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
335992003392	domain I; other site
335992003393	DNA binding groove [nucleotide binding]
335992003394	phosphate binding site [ion binding]; other site
335992003395	domain II; other site
335992003396	domain III; other site
335992003397	nucleotide binding site [chemical binding]; other site
335992003398	catalytic site [active]
335992003399	domain IV; other site
335992003400	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
335992003401	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
335992003402	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
335992003403	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
335992003404	homotrimer interaction site [polypeptide binding]; other site
335992003405	putative active site [active]
335992003406	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
335992003407	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
335992003408	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
335992003409	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335992003410	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
335992003411	active site
335992003412	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992003413	pantoate--beta-alanine ligase; Region: panC; TIGR00018
335992003414	active site
335992003415	nucleotide binding site [chemical binding]; other site
335992003416	HIGH motif; other site
335992003417	KMSKS motif; other site
335992003418	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
335992003419	MgtE intracellular N domain; Region: MgtE_N; smart00924
335992003420	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
335992003421	Divalent cation transporter; Region: MgtE; cl00786
335992003422	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
335992003423	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
335992003424	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
335992003425	active site
335992003426	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
335992003427	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
335992003428	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
335992003429	alphaNTD homodimer interface [polypeptide binding]; other site
335992003430	alphaNTD - beta interaction site [polypeptide binding]; other site
335992003431	alphaNTD - beta' interaction site [polypeptide binding]; other site
335992003432	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
335992003433	30S ribosomal protein S11; Validated; Region: PRK05309
335992003434	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
335992003435	30S ribosomal protein S13; Region: bact_S13; TIGR03631
335992003436	adenylate kinase; Reviewed; Region: adk; PRK00279
335992003437	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
335992003438	AMP-binding site [chemical binding]; other site
335992003439	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
335992003440	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
335992003441	SecY translocase; Region: SecY; pfam00344
335992003442	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
335992003443	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
335992003444	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
335992003445	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
335992003446	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
335992003447	5S rRNA interface [nucleotide binding]; other site
335992003448	23S rRNA interface [nucleotide binding]; other site
335992003449	L5 interface [polypeptide binding]; other site
335992003450	ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654
335992003451	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
335992003452	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
335992003453	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
335992003454	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
335992003455	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
335992003456	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
335992003457	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
335992003458	RNA binding site [nucleotide binding]; other site
335992003459	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
335992003460	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
335992003461	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
335992003462	23S rRNA interface [nucleotide binding]; other site
335992003463	putative translocon interaction site; other site
335992003464	signal recognition particle (SRP54) interaction site; other site
335992003465	L23 interface [polypeptide binding]; other site
335992003466	trigger factor interaction site; other site
335992003467	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
335992003468	23S rRNA interface [nucleotide binding]; other site
335992003469	5S rRNA interface [nucleotide binding]; other site
335992003470	putative antibiotic binding site [chemical binding]; other site
335992003471	L25 interface [polypeptide binding]; other site
335992003472	L27 interface [polypeptide binding]; other site
335992003473	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
335992003474	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
335992003475	G-X-X-G motif; other site
335992003476	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
335992003477	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
335992003478	putative translocon binding site; other site
335992003479	protein-rRNA interface [nucleotide binding]; other site
335992003480	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
335992003481	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
335992003482	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
335992003483	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
335992003484	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
335992003485	50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953
335992003486	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
335992003487	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
335992003488	elongation factor G; Reviewed; Region: PRK00007
335992003489	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
335992003490	G1 box; other site
335992003491	putative GEF interaction site [polypeptide binding]; other site
335992003492	GTP/Mg2+ binding site [chemical binding]; other site
335992003493	Switch I region; other site
335992003494	G2 box; other site
335992003495	G3 box; other site
335992003496	Switch II region; other site
335992003497	G4 box; other site
335992003498	G5 box; other site
335992003499	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
335992003500	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
335992003501	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
335992003502	30S ribosomal protein S7; Validated; Region: PRK05302
335992003503	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
335992003504	S17 interaction site [polypeptide binding]; other site
335992003505	S8 interaction site; other site
335992003506	16S rRNA interaction site [nucleotide binding]; other site
335992003507	streptomycin interaction site [chemical binding]; other site
335992003508	23S rRNA interaction site [nucleotide binding]; other site
335992003509	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
335992003510	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
335992003511	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
335992003512	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
335992003513	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
335992003514	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
335992003515	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
335992003516	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
335992003517	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
335992003518	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
335992003519	DNA binding site [nucleotide binding]
335992003520	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
335992003521	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
335992003522	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
335992003523	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
335992003524	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
335992003525	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
335992003526	RPB12 interaction site [polypeptide binding]; other site
335992003527	RPB11 interaction site [polypeptide binding]; other site
335992003528	RPB12 interaction site [polypeptide binding]; other site
335992003529	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
335992003530	RPB3 interaction site [polypeptide binding]; other site
335992003531	RPB1 interaction site [polypeptide binding]; other site
335992003532	RPB11 interaction site [polypeptide binding]; other site
335992003533	RPB10 interaction site [polypeptide binding]; other site
335992003534	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
335992003535	core dimer interface [polypeptide binding]; other site
335992003536	peripheral dimer interface [polypeptide binding]; other site
335992003537	L10 interface [polypeptide binding]; other site
335992003538	L11 interface [polypeptide binding]; other site
335992003539	putative EF-Tu interaction site [polypeptide binding]; other site
335992003540	putative EF-G interaction site [polypeptide binding]; other site
335992003541	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
335992003542	23S rRNA interface [nucleotide binding]; other site
335992003543	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
335992003544	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
335992003545	mRNA/rRNA interface [nucleotide binding]; other site
335992003546	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
335992003547	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
335992003548	23S rRNA interface [nucleotide binding]; other site
335992003549	L7/L12 interface [polypeptide binding]; other site
335992003550	putative thiostrepton binding site; other site
335992003551	L25 interface [polypeptide binding]; other site
335992003552	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
335992003553	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
335992003554	putative homodimer interface [polypeptide binding]; other site
335992003555	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
335992003556	heterodimer interface [polypeptide binding]; other site
335992003557	homodimer interface [polypeptide binding]; other site
335992003558	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
335992003559	elongation factor Tu; Reviewed; Region: PRK00049
335992003560	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
335992003561	G1 box; other site
335992003562	GEF interaction site [polypeptide binding]; other site
335992003563	GTP/Mg2+ binding site [chemical binding]; other site
335992003564	Switch I region; other site
335992003565	G2 box; other site
335992003566	G3 box; other site
335992003567	Switch II region; other site
335992003568	G4 box; other site
335992003569	G5 box; other site
335992003570	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
335992003571	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
335992003572	Antibiotic Binding Site [chemical binding]; other site
335992003573	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
335992003574	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
335992003575	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
335992003576	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
335992003577	ATP-NAD kinase; Region: NAD_kinase; pfam01513
335992003578	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
335992003579	putative active site pocket [active]
335992003580	putative catalytic residue [active]
335992003581	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
335992003582	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
335992003583	putative MPT binding site; other site
335992003584	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
335992003585	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
335992003586	active site
335992003587	adenylosuccinate lyase; Provisional; Region: PRK07492
335992003588	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
335992003589	tetramer interface [polypeptide binding]; other site
335992003590	active site
335992003591	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
335992003592	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
335992003593	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
335992003594	active site
335992003595	ATP binding site [chemical binding]; other site
335992003596	substrate binding site [chemical binding]; other site
335992003597	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
335992003598	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
335992003599	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
335992003600	putative active site [active]
335992003601	catalytic triad [active]
335992003602	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
335992003603	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
335992003604	dimerization interface [polypeptide binding]; other site
335992003605	ATP binding site [chemical binding]; other site
335992003606	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
335992003607	dimerization interface [polypeptide binding]; other site
335992003608	ATP binding site [chemical binding]; other site
335992003609	BolA-like protein; Region: BolA; pfam01722
335992003610	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
335992003611	putative GSH binding site [chemical binding]; other site
335992003612	catalytic residues [active]
335992003613	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
335992003614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335992003615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335992003616	S-adenosylmethionine binding site [chemical binding]; other site
335992003617	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
335992003618	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
335992003619	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335992003620	RNA binding surface [nucleotide binding]; other site
335992003621	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
335992003622	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
335992003623	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
335992003624	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
335992003625	active site
335992003626	catalytic residues [active]
335992003627	metal binding site [ion binding]; metal-binding site
335992003628	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
335992003629	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
335992003630	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992003631	active site
335992003632	HIGH motif; other site
335992003633	nucleotide binding site [chemical binding]; other site
335992003634	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
335992003635	KMSKS motif; other site
335992003636	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
335992003637	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
335992003638	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
335992003639	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
335992003640	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
335992003641	glutaminase active site [active]
335992003642	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
335992003643	dimer interface [polypeptide binding]; other site
335992003644	active site
335992003645	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
335992003646	dimer interface [polypeptide binding]; other site
335992003647	active site
335992003648	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
335992003649	active site
335992003650	substrate binding site [chemical binding]; other site
335992003651	CoA binding site [chemical binding]; other site
335992003652	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
335992003653	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335992003654	motif II; other site
335992003655	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
335992003656	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
335992003657	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
335992003658	tetramer interface [polypeptide binding]; other site
335992003659	active site
335992003660	Mg2+/Mn2+ binding site [ion binding]; other site
335992003661	citrate synthase; Provisional; Region: PRK14033
335992003662	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
335992003663	dimer interface [polypeptide binding]; other site
335992003664	active site
335992003665	citrylCoA binding site [chemical binding]; other site
335992003666	oxalacetate/citrate binding site [chemical binding]; other site
335992003667	coenzyme A binding site [chemical binding]; other site
335992003668	catalytic triad [active]
335992003669	Methyltransferase domain; Region: Methyltransf_24; pfam13578
335992003670	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
335992003671	dimer interface [polypeptide binding]; other site
335992003672	putative radical transfer pathway; other site
335992003673	diiron center [ion binding]; other site
335992003674	tyrosyl radical; other site
335992003675	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
335992003676	Class I ribonucleotide reductase; Region: RNR_I; cd01679
335992003677	active site
335992003678	dimer interface [polypeptide binding]; other site
335992003679	catalytic residues [active]
335992003680	effector binding site; other site
335992003681	R2 peptide binding site; other site
335992003682	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
335992003683	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
335992003684	active site
335992003685	substrate binding site [chemical binding]; other site
335992003686	metal binding site [ion binding]; metal-binding site
335992003687	Cytochrome P450; Region: p450; cl12078
335992003688	Adenosylmethionine decarboxylase; Region: SAM_decarbox; cl03253
335992003689	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
335992003690	Protein of unknown function DUF91; Region: DUF91; cl00709
335992003691	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335992003692	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992003693	OsmC-like protein; Region: OsmC; pfam02566
335992003694	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
335992003695	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
335992003696	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
335992003697	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
335992003698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335992003699	active site
335992003700	phosphorylation site [posttranslational modification]
335992003701	intermolecular recognition site; other site
335992003702	dimerization interface [polypeptide binding]; other site
335992003703	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335992003704	DNA binding site [nucleotide binding]
335992003705	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
335992003706	PhoU domain; Region: PhoU; pfam01895
335992003707	PhoU domain; Region: PhoU; pfam01895
335992003708	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
335992003709	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
335992003710	Walker A/P-loop; other site
335992003711	ATP binding site [chemical binding]; other site
335992003712	Q-loop/lid; other site
335992003713	ABC transporter signature motif; other site
335992003714	Walker B; other site
335992003715	D-loop; other site
335992003716	H-loop/switch region; other site
335992003717	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
335992003718	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
335992003719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003720	dimer interface [polypeptide binding]; other site
335992003721	conserved gate region; other site
335992003722	putative PBP binding loops; other site
335992003723	ABC-ATPase subunit interface; other site
335992003724	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
335992003725	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
335992003726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003727	dimer interface [polypeptide binding]; other site
335992003728	conserved gate region; other site
335992003729	putative PBP binding loops; other site
335992003730	ABC-ATPase subunit interface; other site
335992003731	PBP superfamily domain; Region: PBP_like_2; cl17296
335992003732	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
335992003733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335992003734	dimer interface [polypeptide binding]; other site
335992003735	phosphorylation site [posttranslational modification]
335992003736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335992003737	ATP binding site [chemical binding]; other site
335992003738	Mg2+ binding site [ion binding]; other site
335992003739	G-X-G motif; other site
335992003740	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
335992003741	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335992003742	Cytochrome c; Region: Cytochrom_C; pfam00034
335992003743	EamA-like transporter family; Region: EamA; pfam00892
335992003744	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
335992003745	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
335992003746	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
335992003747	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
335992003748	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
335992003749	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
335992003750	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
335992003751	NAD(P) binding site [chemical binding]; other site
335992003752	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
335992003753	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
335992003754	Sulfate transporter family; Region: Sulfate_transp; pfam00916
335992003755	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335992003756	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
335992003757	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335992003758	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
335992003759	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
335992003760	FMN binding site [chemical binding]; other site
335992003761	active site
335992003762	catalytic residues [active]
335992003763	substrate binding site [chemical binding]; other site
335992003764	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
335992003765	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335992003766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335992003767	putative substrate translocation pore; other site
335992003768	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335992003769	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335992003770	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
335992003771	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
335992003772	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
335992003773	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
335992003774	trimer interface [polypeptide binding]; other site
335992003775	putative metal binding site [ion binding]; other site
335992003776	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
335992003777	putative catalytic residue [active]
335992003778	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335992003779	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335992003780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
335992003781	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
335992003782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335992003783	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
335992003784	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
335992003785	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
335992003786	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
335992003787	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
335992003788	putative active site [active]
335992003789	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
335992003790	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335992003791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003792	dimer interface [polypeptide binding]; other site
335992003793	conserved gate region; other site
335992003794	putative PBP binding loops; other site
335992003795	ABC-ATPase subunit interface; other site
335992003796	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335992003797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003798	dimer interface [polypeptide binding]; other site
335992003799	conserved gate region; other site
335992003800	putative PBP binding loops; other site
335992003801	ABC-ATPase subunit interface; other site
335992003802	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
335992003803	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335992003804	substrate binding pocket [chemical binding]; other site
335992003805	membrane-bound complex binding site; other site
335992003806	hinge residues; other site
335992003807	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
335992003808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335992003809	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
335992003810	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335992003811	active site
335992003812	TPR repeat; Region: TPR_11; pfam13414
335992003813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335992003814	binding surface
335992003815	TPR motif; other site
335992003816	TPR repeat; Region: TPR_11; pfam13414
335992003817	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
335992003818	sulfotransferase; Region: PLN02164
335992003819	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
335992003820	apolar tunnel; other site
335992003821	heme binding site [chemical binding]; other site
335992003822	dimerization interface [polypeptide binding]; other site
335992003823	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
335992003824	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
335992003825	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
335992003826	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992003827	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335992003828	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
335992003829	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992003830	Cytochrome C' Region: Cytochrom_C_2; pfam01322
335992003831	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
335992003832	Uncharacterized conserved protein [Function unknown]; Region: COG1262
335992003833	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
335992003834	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
335992003835	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
335992003836	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
335992003837	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
335992003838	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
335992003839	active site residue [active]
335992003840	SprT-like family; Region: SprT-like; pfam10263
335992003841	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
335992003842	catalytic residues [active]
335992003843	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992003844	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
335992003845	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
335992003846	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335992003847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335992003848	Walker A/P-loop; other site
335992003849	ATP binding site [chemical binding]; other site
335992003850	Q-loop/lid; other site
335992003851	ABC transporter signature motif; other site
335992003852	Walker B; other site
335992003853	D-loop; other site
335992003854	H-loop/switch region; other site
335992003855	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
335992003856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003857	dimer interface [polypeptide binding]; other site
335992003858	conserved gate region; other site
335992003859	ABC-ATPase subunit interface; other site
335992003860	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335992003861	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
335992003862	isocitrate lyase; Provisional; Region: PRK15063
335992003863	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
335992003864	tetramer interface [polypeptide binding]; other site
335992003865	active site
335992003866	Mg2+/Mn2+ binding site [ion binding]; other site
335992003867	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335992003868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335992003869	non-specific DNA binding site [nucleotide binding]; other site
335992003870	salt bridge; other site
335992003871	sequence-specific DNA binding site [nucleotide binding]; other site
335992003872	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
335992003873	Domain of unknown function (DUF955); Region: DUF955; pfam06114
335992003874	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
335992003875	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335992003876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335992003877	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335992003878	putative effector binding pocket; other site
335992003879	dimerization interface [polypeptide binding]; other site
335992003880	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
335992003881	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
335992003882	NADP binding site [chemical binding]; other site
335992003883	dimer interface [polypeptide binding]; other site
335992003884	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
335992003885	GTP cyclohydrolase I; Provisional; Region: PLN03044
335992003886	active site
335992003887	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
335992003888	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
335992003889	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
335992003890	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
335992003891	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335992003892	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
335992003893	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
335992003894	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
335992003895	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
335992003896	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
335992003897	Ligand binding site [chemical binding]; other site
335992003898	Electron transfer flavoprotein domain; Region: ETF; pfam01012
335992003899	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992003900	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335992003901	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
335992003902	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992003903	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
335992003904	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335992003905	Predicted transporter component [General function prediction only]; Region: COG2391
335992003906	Sulphur transport; Region: Sulf_transp; pfam04143
335992003907	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
335992003908	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
335992003909	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335992003910	enoyl-CoA hydratase; Validated; Region: PRK08139
335992003911	substrate binding site [chemical binding]; other site
335992003912	oxyanion hole (OAH) forming residues; other site
335992003913	trimer interface [polypeptide binding]; other site
335992003914	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
335992003915	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335992003916	active site
335992003917	HIGH motif; other site
335992003918	nucleotide binding site [chemical binding]; other site
335992003919	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
335992003920	AAA domain; Region: AAA_33; pfam13671
335992003921	active site
335992003922	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
335992003923	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
335992003924	[2Fe-2S] cluster binding site [ion binding]; other site
335992003925	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
335992003926	alpha subunit interface [polypeptide binding]; other site
335992003927	active site
335992003928	substrate binding site [chemical binding]; other site
335992003929	Fe binding site [ion binding]; other site
335992003930	FAD binding site [chemical binding]; other site
335992003931	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
335992003932	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
335992003933	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992003934	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
335992003935	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335992003936	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
335992003937	active site
335992003938	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
335992003939	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
335992003940	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335992003941	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335992003942	Coenzyme A binding pocket [chemical binding]; other site
335992003943	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335992003944	DNA-binding site [nucleotide binding]; DNA binding site
335992003945	RNA-binding motif; other site
335992003946	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335992003947	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
335992003948	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
335992003949	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335992003950	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992003951	EamA-like transporter family; Region: EamA; cl17759
335992003952	EamA-like transporter family; Region: EamA; pfam00892
335992003953	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
335992003954	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
335992003955	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
335992003956	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335992003957	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992003958	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
335992003959	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
335992003960	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335992003961	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335992003962	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
335992003963	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
335992003964	Potassium binding sites [ion binding]; other site
335992003965	Cesium cation binding sites [ion binding]; other site
335992003966	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
335992003967	catalytic triad [active]
335992003968	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
335992003969	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
335992003970	putative active site [active]
335992003971	metal binding site [ion binding]; metal-binding site
335992003972	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
335992003973	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992003974	NAD(P) binding site [chemical binding]; other site
335992003975	catalytic residues [active]
335992003976	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335992003977	classical (c) SDRs; Region: SDR_c; cd05233
335992003978	NAD(P) binding site [chemical binding]; other site
335992003979	active site
335992003980	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335992003981	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
335992003982	DctM-like transporters; Region: DctM; pfam06808
335992003983	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
335992003984	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
335992003985	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
335992003986	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
335992003987	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335992003988	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
335992003989	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
335992003990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003991	dimer interface [polypeptide binding]; other site
335992003992	conserved gate region; other site
335992003993	putative PBP binding loops; other site
335992003994	ABC-ATPase subunit interface; other site
335992003995	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335992003996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992003997	dimer interface [polypeptide binding]; other site
335992003998	conserved gate region; other site
335992003999	putative PBP binding loops; other site
335992004000	ABC-ATPase subunit interface; other site
335992004001	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
335992004002	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
335992004003	Walker A/P-loop; other site
335992004004	ATP binding site [chemical binding]; other site
335992004005	Q-loop/lid; other site
335992004006	ABC transporter signature motif; other site
335992004007	Walker B; other site
335992004008	D-loop; other site
335992004009	H-loop/switch region; other site
335992004010	MORN repeat; Region: MORN; cl14787
335992004011	MORN repeat; Region: MORN; cl14787
335992004012	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
335992004013	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
335992004014	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
335992004015	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
335992004016	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
335992004017	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335992004018	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992004019	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335992004020	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
335992004021	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
335992004022	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
335992004023	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
335992004024	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
335992004025	putative active site [active]
335992004026	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
335992004027	domain_subunit interface; other site
335992004028	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
335992004029	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
335992004030	active site
335992004031	FMN binding site [chemical binding]; other site
335992004032	substrate binding site [chemical binding]; other site
335992004033	3Fe-4S cluster binding site [ion binding]; other site
335992004034	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
335992004035	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
335992004036	putative active site [active]
335992004037	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
335992004038	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
335992004039	domain_subunit interface; other site
335992004040	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
335992004041	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
335992004042	active site
335992004043	FMN binding site [chemical binding]; other site
335992004044	substrate binding site [chemical binding]; other site
335992004045	3Fe-4S cluster binding site [ion binding]; other site
335992004046	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
335992004047	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
335992004048	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
335992004049	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
335992004050	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335992004051	catalytic residue [active]
335992004052	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
335992004053	DNA photolyase; Region: DNA_photolyase; pfam00875
335992004054	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
335992004055	Predicted ATPase [General function prediction only]; Region: COG1485
335992004056	PQQ-like domain; Region: PQQ_2; pfam13360
335992004057	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
335992004058	Trp docking motif [polypeptide binding]; other site
335992004059	aconitate hydratase; Validated; Region: PRK09277
335992004060	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
335992004061	substrate binding site [chemical binding]; other site
335992004062	ligand binding site [chemical binding]; other site
335992004063	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
335992004064	substrate binding site [chemical binding]; other site
335992004065	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335992004066	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
335992004067	dimer interface [polypeptide binding]; other site
335992004068	putative tRNA-binding site [nucleotide binding]; other site
335992004069	acetylornithine deacetylase; Provisional; Region: PRK07522
335992004070	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
335992004071	metal binding site [ion binding]; metal-binding site
335992004072	putative dimer interface [polypeptide binding]; other site
335992004073	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
335992004074	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992004075	NAD binding site [chemical binding]; other site
335992004076	catalytic residues [active]
335992004077	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
335992004078	agmatinase; Region: agmatinase; TIGR01230
335992004079	oligomer interface [polypeptide binding]; other site
335992004080	putative active site [active]
335992004081	Mn binding site [ion binding]; other site
335992004082	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
335992004083	active site
335992004084	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
335992004085	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335992004086	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335992004087	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335992004088	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335992004089	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335992004090	substrate binding site [chemical binding]; other site
335992004091	oxyanion hole (OAH) forming residues; other site
335992004092	trimer interface [polypeptide binding]; other site
335992004093	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335992004094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992004095	dimer interface [polypeptide binding]; other site
335992004096	conserved gate region; other site
335992004097	putative PBP binding loops; other site
335992004098	ABC-ATPase subunit interface; other site
335992004099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335992004100	dimer interface [polypeptide binding]; other site
335992004101	conserved gate region; other site
335992004102	putative PBP binding loops; other site
335992004103	ABC-ATPase subunit interface; other site
335992004104	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335992004105	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335992004106	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
335992004107	Walker A/P-loop; other site
335992004108	ATP binding site [chemical binding]; other site
335992004109	Q-loop/lid; other site
335992004110	ABC transporter signature motif; other site
335992004111	Walker B; other site
335992004112	D-loop; other site
335992004113	H-loop/switch region; other site
335992004114	TOBE domain; Region: TOBE_2; pfam08402
335992004115	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
335992004116	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
335992004117	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
335992004118	active site
335992004119	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335992004120	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
335992004121	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
335992004122	Amino acid synthesis; Region: AA_synth; pfam06684
335992004123	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335992004124	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335992004125	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
335992004126	NAD(P) binding site [chemical binding]; other site
335992004127	catalytic residues [active]
335992004128	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992004129	EamA-like transporter family; Region: EamA; pfam00892
335992004130	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335992004131	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
335992004132	putative ligand binding site [chemical binding]; other site
335992004133	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335992004134	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335992004135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335992004136	putative substrate translocation pore; other site
335992004137	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335992004138	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335992004139	TM-ABC transporter signature motif; other site
335992004140	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335992004141	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335992004142	TM-ABC transporter signature motif; other site
335992004143	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335992004144	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335992004145	Walker A/P-loop; other site
335992004146	ATP binding site [chemical binding]; other site
335992004147	Q-loop/lid; other site
335992004148	ABC transporter signature motif; other site
335992004149	Walker B; other site
335992004150	D-loop; other site
335992004151	H-loop/switch region; other site
335992004152	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335992004153	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335992004154	Walker A/P-loop; other site
335992004155	ATP binding site [chemical binding]; other site
335992004156	Q-loop/lid; other site
335992004157	ABC transporter signature motif; other site
335992004158	Walker B; other site
335992004159	D-loop; other site
335992004160	H-loop/switch region; other site
335992004161	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476
335992004162	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
335992004163	carbon starvation induced protein; Validated; Region: PRK02963
335992004164	substrate binding pocket [chemical binding]; other site
335992004165	active site
335992004166	iron coordination sites [ion binding]; other site
335992004167	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
335992004168	AzlC protein; Region: AzlC; pfam03591
335992004169	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335992004170	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335992004171	Walker A/P-loop; other site
335992004172	ATP binding site [chemical binding]; other site
335992004173	Q-loop/lid; other site
335992004174	ABC transporter signature motif; other site
335992004175	Walker B; other site
335992004176	D-loop; other site
335992004177	H-loop/switch region; other site
335992004178	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335992004179	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335992004180	Walker A/P-loop; other site
335992004181	ATP binding site [chemical binding]; other site
335992004182	Q-loop/lid; other site
335992004183	ABC transporter signature motif; other site
335992004184	Walker B; other site
335992004185	D-loop; other site
335992004186	H-loop/switch region; other site
335992004187	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335992004188	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335992004189	TM-ABC transporter signature motif; other site
335992004190	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335992004191	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335992004192	TM-ABC transporter signature motif; other site
335992004193	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335992004194	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
335992004195	putative ligand binding site [chemical binding]; other site
335992004196	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335992004197	TIGR03643 family protein; Region: TIGR03643
335992004198	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
335992004199	GSH binding site [chemical binding]; other site
335992004200	catalytic residues [active]
335992004201	SelR domain; Region: SelR; pfam01641
335992004202	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
335992004203	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
335992004204	dimerization interface [polypeptide binding]; other site
335992004205	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
335992004206	NAD binding site [chemical binding]; other site
335992004207	ligand binding site [chemical binding]; other site
335992004208	catalytic site [active]
335992004209	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335992004210	EamA-like transporter family; Region: EamA; pfam00892
335992004211	EamA-like transporter family; Region: EamA; pfam00892
335992004212	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335992004213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335992004214	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
335992004215	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
335992004216	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
335992004217	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
335992004218	rod shape-determining protein MreC; Provisional; Region: PRK13922
335992004219	rod shape-determining protein MreC; Region: MreC; pfam04085
335992004220	rod shape-determining protein MreB; Provisional; Region: PRK13927
335992004221	MreB and similar proteins; Region: MreB_like; cd10225
335992004222	nucleotide binding site [chemical binding]; other site
335992004223	Mg binding site [ion binding]; other site
335992004224	putative protofilament interaction site [polypeptide binding]; other site
335992004225	RodZ interaction site [polypeptide binding]; other site
335992004226	2-isopropylmalate synthase; Validated; Region: PRK00915
335992004227	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
335992004228	active site
335992004229	metal binding site [ion binding]; metal-binding site
335992004230	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
335992004231	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974