-- dump date 20140619_024837 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264201000001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 264201000002 putative phosphoketolase; Provisional; Region: PRK05261 264201000003 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 264201000004 TPP-binding site; other site 264201000005 XFP C-terminal domain; Region: XFP_C; pfam09363 264201000006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201000007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264201000008 putative substrate translocation pore; other site 264201000009 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264201000010 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264201000011 putative acyl-acceptor binding pocket; other site 264201000012 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 264201000013 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 264201000014 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 264201000015 Part of AAA domain; Region: AAA_19; pfam13245 264201000016 Family description; Region: UvrD_C_2; pfam13538 264201000017 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 264201000018 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 264201000019 AAA domain; Region: AAA_30; pfam13604 264201000020 Family description; Region: UvrD_C_2; pfam13538 264201000021 NMT1-like family; Region: NMT1_2; pfam13379 264201000022 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264201000023 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264201000024 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 264201000025 Walker A/P-loop; other site 264201000026 ATP binding site [chemical binding]; other site 264201000027 Q-loop/lid; other site 264201000028 ABC transporter signature motif; other site 264201000029 Walker B; other site 264201000030 D-loop; other site 264201000031 H-loop/switch region; other site 264201000032 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264201000033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201000034 dimer interface [polypeptide binding]; other site 264201000035 conserved gate region; other site 264201000036 putative PBP binding loops; other site 264201000037 ABC-ATPase subunit interface; other site 264201000038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201000039 active site 264201000040 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264201000041 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264201000042 putative active site [active] 264201000043 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201000044 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 264201000045 active site 264201000046 putative DNA-binding cleft [nucleotide binding]; other site 264201000047 dimer interface [polypeptide binding]; other site 264201000048 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264201000049 RuvA N terminal domain; Region: RuvA_N; pfam01330 264201000050 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264201000051 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 264201000052 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264201000053 minor groove reading motif; other site 264201000054 helix-hairpin-helix signature motif; other site 264201000055 substrate binding pocket [chemical binding]; other site 264201000056 active site 264201000057 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264201000058 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264201000059 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264201000060 G1 box; other site 264201000061 GTP/Mg2+ binding site [chemical binding]; other site 264201000062 Switch I region; other site 264201000063 G2 box; other site 264201000064 Switch II region; other site 264201000065 G3 box; other site 264201000066 G4 box; other site 264201000067 G5 box; other site 264201000068 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264201000069 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 264201000070 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264201000071 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 264201000072 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264201000073 catalytic triad [active] 264201000074 dimer interface [polypeptide binding]; other site 264201000075 peroxidatic and resolving cysteines [active] 264201000076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 264201000077 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264201000078 RHS Repeat; Region: RHS_repeat; pfam05593 264201000079 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264201000080 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 264201000081 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 264201000082 chaperonin GroL; Region: GroEL; TIGR02348 264201000083 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264201000084 ring oligomerisation interface [polypeptide binding]; other site 264201000085 ATP/Mg binding site [chemical binding]; other site 264201000086 stacking interactions; other site 264201000087 hinge regions; other site 264201000088 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264201000089 oligomerisation interface [polypeptide binding]; other site 264201000090 mobile loop; other site 264201000091 roof hairpin; other site 264201000092 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 264201000093 Proline dehydrogenase; Region: Pro_dh; cl03282 264201000094 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 264201000095 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264201000096 Glutamate binding site [chemical binding]; other site 264201000097 NAD binding site [chemical binding]; other site 264201000098 catalytic residues [active] 264201000099 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 264201000100 Part of AAA domain; Region: AAA_19; pfam13245 264201000101 Family description; Region: UvrD_C_2; pfam13538 264201000102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264201000103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264201000104 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 264201000105 active site 264201000106 Zn binding site [ion binding]; other site 264201000107 Leucine rich repeat; Region: LRR_8; pfam13855 264201000108 Leucine rich repeat; Region: LRR_8; pfam13855 264201000109 Leucine rich repeat; Region: LRR_8; pfam13855 264201000110 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000112 binding surface 264201000113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000114 TPR motif; other site 264201000115 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000117 binding surface 264201000118 TPR motif; other site 264201000119 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000120 TPR repeat; Region: TPR_11; pfam13414 264201000121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000122 binding surface 264201000123 TPR motif; other site 264201000124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000125 CHAT domain; Region: CHAT; pfam12770 264201000126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000127 binding surface 264201000128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000129 TPR motif; other site 264201000130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000133 TPR repeat; Region: TPR_11; pfam13414 264201000134 binding surface 264201000135 TPR motif; other site 264201000136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000137 TPR repeat; Region: TPR_11; pfam13414 264201000138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000139 binding surface 264201000140 TPR motif; other site 264201000141 CHAT domain; Region: CHAT; pfam12770 264201000142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000144 binding surface 264201000145 TPR motif; other site 264201000146 TPR repeat; Region: TPR_11; pfam13414 264201000147 TPR repeat; Region: TPR_11; pfam13414 264201000148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000150 binding surface 264201000151 TPR motif; other site 264201000152 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000155 binding surface 264201000156 TPR motif; other site 264201000157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000158 CHAT domain; Region: CHAT; pfam12770 264201000159 chromosome segregation protein; Provisional; Region: PRK02224 264201000160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000162 TPR motif; other site 264201000163 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000164 binding surface 264201000165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000166 binding surface 264201000167 TPR motif; other site 264201000168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000169 CHAT domain; Region: CHAT; pfam12770 264201000170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000172 TPR motif; other site 264201000173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000174 binding surface 264201000175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000177 TPR motif; other site 264201000178 binding surface 264201000179 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000180 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000182 binding surface 264201000183 TPR motif; other site 264201000184 TPR repeat; Region: TPR_11; pfam13414 264201000185 CHAT domain; Region: CHAT; pfam12770 264201000186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000187 binding surface 264201000188 TPR motif; other site 264201000189 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000191 binding surface 264201000192 TPR motif; other site 264201000193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000195 binding surface 264201000196 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264201000197 TPR motif; other site 264201000198 CHAT domain; Region: CHAT; pfam12770 264201000199 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201000200 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201000201 Leucine rich repeat; Region: LRR_8; pfam13855 264201000202 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cl17238 264201000203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264201000204 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264201000205 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000208 binding surface 264201000209 TPR motif; other site 264201000210 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 264201000211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000212 binding surface 264201000213 TPR motif; other site 264201000214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000215 binding surface 264201000216 TPR motif; other site 264201000217 CHAT domain; Region: CHAT; pfam12770 264201000218 CHAT domain; Region: CHAT; pfam12770 264201000219 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000220 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000222 binding surface 264201000223 TPR motif; other site 264201000224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000226 binding surface 264201000227 TPR motif; other site 264201000228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000231 binding surface 264201000232 TPR motif; other site 264201000233 TPR repeat; Region: TPR_11; pfam13414 264201000234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000235 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000237 binding surface 264201000238 TPR motif; other site 264201000239 TPR repeat; Region: TPR_11; pfam13414 264201000240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000241 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000243 binding surface 264201000244 TPR motif; other site 264201000245 TPR repeat; Region: TPR_11; pfam13414 264201000246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000247 binding surface 264201000248 TPR motif; other site 264201000249 CHAT domain; Region: CHAT; pfam12770 264201000250 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201000251 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000253 TPR motif; other site 264201000254 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000255 binding surface 264201000256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000258 binding surface 264201000259 TPR motif; other site 264201000260 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000262 TPR motif; other site 264201000263 binding surface 264201000264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000267 binding surface 264201000268 TPR motif; other site 264201000269 TPR repeat; Region: TPR_11; pfam13414 264201000270 CHAT domain; Region: CHAT; pfam12770 264201000271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000273 TPR motif; other site 264201000274 binding surface 264201000275 TPR repeat; Region: TPR_11; pfam13414 264201000276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000277 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000279 binding surface 264201000280 TPR motif; other site 264201000281 TPR repeat; Region: TPR_11; pfam13414 264201000282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000283 CHAT domain; Region: CHAT; pfam12770 264201000284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000287 binding surface 264201000288 TPR motif; other site 264201000289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000291 binding surface 264201000292 TPR motif; other site 264201000293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201000294 TPR repeat; Region: TPR_11; pfam13414 264201000295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000296 binding surface 264201000297 TPR motif; other site 264201000298 CHAT domain; Region: CHAT; pfam12770 264201000299 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 264201000300 active site 264201000301 Zn binding site [ion binding]; other site 264201000302 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 264201000303 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 264201000304 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 264201000305 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264201000306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201000307 rod shape-determining protein MreC; Provisional; Region: PRK14872 264201000308 rod shape-determining protein MreC; Region: MreC; pfam04085 264201000309 rod shape-determining protein MreC; Region: MreC; pfam04085 264201000310 Transposase IS200 like; Region: Y1_Tnp; cl00848 264201000311 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264201000312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264201000313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201000314 homodimer interface [polypeptide binding]; other site 264201000315 catalytic residue [active] 264201000316 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 264201000317 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 264201000318 active site 264201000319 interdomain interaction site; other site 264201000320 putative metal-binding site [ion binding]; other site 264201000321 nucleotide binding site [chemical binding]; other site 264201000322 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264201000323 domain I; other site 264201000324 DNA binding groove [nucleotide binding] 264201000325 phosphate binding site [ion binding]; other site 264201000326 domain II; other site 264201000327 domain III; other site 264201000328 nucleotide binding site [chemical binding]; other site 264201000329 catalytic site [active] 264201000330 domain IV; other site 264201000331 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264201000332 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264201000333 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264201000334 SWIB/MDM2 domain; Region: SWIB; pfam02201 264201000335 DNA protecting protein DprA; Region: dprA; TIGR00732 264201000336 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 264201000337 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264201000338 active site 264201000339 dimer interface [polypeptide binding]; other site 264201000340 metal binding site [ion binding]; metal-binding site 264201000341 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 264201000342 ParB-like nuclease domain; Region: ParB; smart00470 264201000343 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264201000344 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264201000345 metal-binding site [ion binding] 264201000346 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264201000347 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264201000348 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264201000349 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 264201000350 putative NAD(P) binding site [chemical binding]; other site 264201000351 active site 264201000352 putative substrate binding site [chemical binding]; other site 264201000353 putative carbohydrate kinase; Provisional; Region: PRK10565 264201000354 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 264201000355 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264201000356 putative substrate binding site [chemical binding]; other site 264201000357 putative ATP binding site [chemical binding]; other site 264201000358 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 264201000359 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 264201000360 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264201000361 YacP-like NYN domain; Region: NYN_YacP; cl01491 264201000362 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264201000363 active site 264201000364 dimerization interface [polypeptide binding]; other site 264201000365 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 264201000366 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264201000367 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264201000368 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 264201000369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264201000370 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 264201000371 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 264201000372 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264201000373 minor groove reading motif; other site 264201000374 helix-hairpin-helix signature motif; other site 264201000375 substrate binding pocket [chemical binding]; other site 264201000376 active site 264201000377 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 264201000378 DNA binding and oxoG recognition site [nucleotide binding] 264201000379 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264201000380 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 264201000381 catalytic triad [active] 264201000382 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 264201000383 dimer interface [polypeptide binding]; other site 264201000384 active site 264201000385 aspartate-rich active site metal binding site; other site 264201000386 allosteric magnesium binding site [ion binding]; other site 264201000387 Schiff base residues; other site 264201000388 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 264201000389 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264201000390 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264201000391 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 264201000392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264201000393 E3 interaction surface; other site 264201000394 lipoyl attachment site [posttranslational modification]; other site 264201000395 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 264201000396 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 264201000397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264201000398 Walker A/P-loop; other site 264201000399 ATP binding site [chemical binding]; other site 264201000400 Q-loop/lid; other site 264201000401 ABC transporter signature motif; other site 264201000402 Walker B; other site 264201000403 D-loop; other site 264201000404 H-loop/switch region; other site 264201000405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264201000406 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264201000407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264201000408 Walker A/P-loop; other site 264201000409 ATP binding site [chemical binding]; other site 264201000410 Q-loop/lid; other site 264201000411 ABC transporter signature motif; other site 264201000412 Walker B; other site 264201000413 D-loop; other site 264201000414 H-loop/switch region; other site 264201000415 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 264201000416 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 264201000417 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264201000418 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 264201000419 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264201000420 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264201000421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201000422 dimer interface [polypeptide binding]; other site 264201000423 conserved gate region; other site 264201000424 ABC-ATPase subunit interface; other site 264201000425 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264201000426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201000427 dimer interface [polypeptide binding]; other site 264201000428 conserved gate region; other site 264201000429 putative PBP binding loops; other site 264201000430 ABC-ATPase subunit interface; other site 264201000431 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 264201000432 peptide binding site [polypeptide binding]; other site 264201000433 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264201000434 Family description; Region: DsbD_2; pfam13386 264201000435 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 264201000436 homodimer interface [polypeptide binding]; other site 264201000437 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 264201000438 active site pocket [active] 264201000439 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264201000440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264201000441 substrate binding pocket [chemical binding]; other site 264201000442 membrane-bound complex binding site; other site 264201000443 hinge residues; other site 264201000444 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 264201000445 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 264201000446 ligand binding site; other site 264201000447 oligomer interface; other site 264201000448 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 264201000449 dimer interface [polypeptide binding]; other site 264201000450 N-terminal domain interface [polypeptide binding]; other site 264201000451 sulfate 1 binding site; other site 264201000452 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 264201000453 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264201000454 putative active site [active] 264201000455 putative metal binding site [ion binding]; other site 264201000456 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 264201000457 Class II ribonucleotide reductase, monomeric form; Region: RNR_II_monomer; cd01676 264201000458 putative active site [active] 264201000459 Src Homology 3 domain superfamily; Region: SH3; cl17036 264201000460 peptide ligand binding site [polypeptide binding]; other site 264201000461 Domain of unknown function (DUF202); Region: DUF202; pfam02656 264201000462 Oxygen tolerance; Region: BatD; pfam13584 264201000463 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264201000464 metal ion-dependent adhesion site (MIDAS); other site 264201000465 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264201000466 metal ion-dependent adhesion site (MIDAS); other site 264201000467 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264201000468 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264201000469 alpha-glucosidase; Provisional; Region: PRK10137 264201000470 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 264201000471 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264201000472 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264201000473 substrate binding site; other site 264201000474 tetramer interface; other site 264201000475 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 264201000476 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 264201000477 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 264201000478 NADP binding site [chemical binding]; other site 264201000479 active site 264201000480 putative substrate binding site [chemical binding]; other site 264201000481 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264201000482 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264201000483 NAD binding site [chemical binding]; other site 264201000484 substrate binding site [chemical binding]; other site 264201000485 homodimer interface [polypeptide binding]; other site 264201000486 active site 264201000487 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264201000488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201000489 putative substrate translocation pore; other site 264201000490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201000491 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264201000492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264201000493 HlyD family secretion protein; Region: HlyD_3; pfam13437 264201000494 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 264201000495 active site 264201000496 catalytic residues [active] 264201000497 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264201000498 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264201000499 active site 264201000500 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 264201000501 Predicted acyl esterases [General function prediction only]; Region: COG2936 264201000502 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 264201000503 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 264201000504 active site 264201000505 metal-binding site 264201000506 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264201000507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 264201000508 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264201000509 rRNA interaction site [nucleotide binding]; other site 264201000510 S8 interaction site; other site 264201000511 putative laminin-1 binding site; other site 264201000512 elongation factor Ts; Provisional; Region: tsf; PRK09377 264201000513 UBA/TS-N domain; Region: UBA; pfam00627 264201000514 Elongation factor TS; Region: EF_TS; pfam00889 264201000515 Elongation factor TS; Region: EF_TS; pfam00889 264201000516 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264201000517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264201000518 ATP binding site [chemical binding]; other site 264201000519 Mg2+ binding site [ion binding]; other site 264201000520 G-X-G motif; other site 264201000521 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 264201000522 ATP binding site [chemical binding]; other site 264201000523 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 264201000524 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 264201000525 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264201000526 active site 264201000527 NTP binding site [chemical binding]; other site 264201000528 metal binding triad [ion binding]; metal-binding site 264201000529 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264201000530 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264201000531 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 264201000532 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264201000533 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 264201000534 RNA binding site [nucleotide binding]; other site 264201000535 homodimer interface [polypeptide binding]; other site 264201000536 GTPase RsgA; Reviewed; Region: PRK00098 264201000537 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264201000538 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264201000539 GTP/Mg2+ binding site [chemical binding]; other site 264201000540 G4 box; other site 264201000541 G5 box; other site 264201000542 G1 box; other site 264201000543 Switch I region; other site 264201000544 G2 box; other site 264201000545 G3 box; other site 264201000546 Switch II region; other site 264201000547 enolase; Provisional; Region: eno; PRK00077 264201000548 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264201000549 dimer interface [polypeptide binding]; other site 264201000550 metal binding site [ion binding]; metal-binding site 264201000551 substrate binding pocket [chemical binding]; other site 264201000552 Bax inhibitor 1 like; Region: BaxI_1; cl17691 264201000553 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 264201000554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201000555 ATP binding site [chemical binding]; other site 264201000556 putative Mg++ binding site [ion binding]; other site 264201000557 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 264201000558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201000559 nucleotide binding region [chemical binding]; other site 264201000560 ATP-binding site [chemical binding]; other site 264201000561 SEC-C motif; Region: SEC-C; pfam02810 264201000562 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 264201000563 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 264201000564 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 264201000565 transmembrane helices; other site 264201000566 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 264201000567 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 264201000568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264201000569 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264201000570 lipoyl synthase; Provisional; Region: PRK05481 264201000571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201000572 FeS/SAM binding site; other site 264201000573 farnesyltranstransferase; Region: PLN02789 264201000574 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201000575 Sel1-like repeats; Region: SEL1; smart00671 264201000576 Sel1-like repeats; Region: SEL1; smart00671 264201000577 Sel1-like repeats; Region: SEL1; smart00671 264201000578 Sel1-like repeats; Region: SEL1; smart00671 264201000579 Sel1-like repeats; Region: SEL1; smart00671 264201000580 Thymidylate synthase complementing protein; Region: Thy1; cl03630 264201000581 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 264201000582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201000583 S-adenosylmethionine binding site [chemical binding]; other site 264201000584 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264201000585 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264201000586 RNA binding surface [nucleotide binding]; other site 264201000587 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264201000588 active site 264201000589 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264201000590 catalytic core [active] 264201000591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264201000592 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264201000593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264201000594 catalytic residue [active] 264201000595 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 264201000596 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264201000597 NifU-like domain; Region: NifU; cl00484 264201000598 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 264201000599 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264201000600 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 264201000601 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 264201000602 aromatic amino acid transport protein; Region: araaP; TIGR00837 264201000603 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 264201000604 aromatic amino acid transport protein; Region: araaP; TIGR00837 264201000605 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264201000606 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264201000607 active site 264201000608 HIGH motif; other site 264201000609 dimer interface [polypeptide binding]; other site 264201000610 KMSKS motif; other site 264201000611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000612 TPR motif; other site 264201000613 binding surface 264201000614 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264201000615 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 264201000616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264201000617 binding surface 264201000618 TPR motif; other site 264201000619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201000620 binding surface 264201000621 TPR repeat; Region: TPR_11; pfam13414 264201000622 TPR motif; other site 264201000623 excinuclease ABC subunit B; Provisional; Region: PRK05298 264201000624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201000625 ATP binding site [chemical binding]; other site 264201000626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201000627 nucleotide binding region [chemical binding]; other site 264201000628 ATP-binding site [chemical binding]; other site 264201000629 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264201000630 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 264201000631 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264201000632 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 264201000633 DEAD_2; Region: DEAD_2; pfam06733 264201000634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201000635 nucleotide binding region [chemical binding]; other site 264201000636 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264201000637 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264201000638 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264201000639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264201000640 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264201000641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264201000642 DNA binding residues [nucleotide binding] 264201000643 Competence protein CoiA-like family; Region: CoiA; cl11541 264201000644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201000645 S-adenosylmethionine binding site [chemical binding]; other site 264201000646 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 264201000647 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 264201000648 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 264201000649 Walker A/P-loop; other site 264201000650 ATP binding site [chemical binding]; other site 264201000651 Q-loop/lid; other site 264201000652 ABC transporter signature motif; other site 264201000653 Walker B; other site 264201000654 D-loop; other site 264201000655 H-loop/switch region; other site 264201000656 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 264201000657 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 264201000658 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264201000659 IncA protein; Region: IncA; pfam04156 264201000660 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 264201000661 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264201000662 polysaccharide export protein Wza; Provisional; Region: PRK15078 264201000663 SLBB domain; Region: SLBB; pfam10531 264201000664 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 264201000665 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264201000666 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264201000667 Probable Catalytic site; other site 264201000668 metal-binding site 264201000669 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 264201000670 putative ABC transporter; Region: ycf24; CHL00085 264201000671 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 264201000672 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 264201000673 Walker A/P-loop; other site 264201000674 ATP binding site [chemical binding]; other site 264201000675 Q-loop/lid; other site 264201000676 ABC transporter signature motif; other site 264201000677 Walker B; other site 264201000678 D-loop; other site 264201000679 H-loop/switch region; other site 264201000680 FeS assembly protein SufD; Region: sufD; TIGR01981 264201000681 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 264201000682 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264201000683 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 264201000684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264201000685 catalytic residue [active] 264201000686 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 264201000687 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 264201000688 transglutaminase; Provisional; Region: tgl; PRK03187 264201000689 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 264201000690 active site 264201000691 Zn binding site [ion binding]; other site 264201000692 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264201000693 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 264201000694 putative active site [active] 264201000695 catalytic site [active] 264201000696 putative metal binding site [ion binding]; other site 264201000697 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201000698 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201000699 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201000700 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 264201000701 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 264201000702 type III secretion system protein; Reviewed; Region: PRK09617 264201000703 type III secretion system protein; Validated; Region: PRK06328 264201000704 Flagellar assembly protein FliH; Region: FliH; pfam02108 264201000705 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 264201000706 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 264201000707 elongation factor G; Reviewed; Region: PRK12739 264201000708 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264201000709 G1 box; other site 264201000710 putative GEF interaction site [polypeptide binding]; other site 264201000711 GTP/Mg2+ binding site [chemical binding]; other site 264201000712 Switch I region; other site 264201000713 G2 box; other site 264201000714 G3 box; other site 264201000715 Switch II region; other site 264201000716 G4 box; other site 264201000717 G5 box; other site 264201000718 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264201000719 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264201000720 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264201000721 30S ribosomal protein S7; Validated; Region: PRK05302 264201000722 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264201000723 S17 interaction site [polypeptide binding]; other site 264201000724 S8 interaction site; other site 264201000725 16S rRNA interaction site [nucleotide binding]; other site 264201000726 streptomycin interaction site [chemical binding]; other site 264201000727 23S rRNA interaction site [nucleotide binding]; other site 264201000728 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264201000729 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 264201000730 ScpA/B protein; Region: ScpA_ScpB; cl00598 264201000731 C-terminal peptidase (prc); Region: prc; TIGR00225 264201000732 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264201000733 protein binding site [polypeptide binding]; other site 264201000734 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264201000735 Catalytic dyad [active] 264201000736 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 264201000737 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 264201000738 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 264201000739 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 264201000740 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 264201000741 GTP1/OBG; Region: GTP1_OBG; pfam01018 264201000742 Obg GTPase; Region: Obg; cd01898 264201000743 G1 box; other site 264201000744 GTP/Mg2+ binding site [chemical binding]; other site 264201000745 Switch I region; other site 264201000746 G2 box; other site 264201000747 G3 box; other site 264201000748 Switch II region; other site 264201000749 G4 box; other site 264201000750 G5 box; other site 264201000751 transcription termination factor Rho; Provisional; Region: rho; PRK09376 264201000752 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 264201000753 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264201000754 RNA binding site [nucleotide binding]; other site 264201000755 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264201000756 multimer interface [polypeptide binding]; other site 264201000757 Walker A motif; other site 264201000758 ATP binding site [chemical binding]; other site 264201000759 Walker B motif; other site 264201000760 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264201000761 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264201000762 CoA-binding site [chemical binding]; other site 264201000763 ATP-binding [chemical binding]; other site 264201000764 DNA polymerase I; Provisional; Region: PRK05755 264201000765 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264201000766 active site 264201000767 metal binding site 1 [ion binding]; metal-binding site 264201000768 putative 5' ssDNA interaction site; other site 264201000769 metal binding site 3; metal-binding site 264201000770 metal binding site 2 [ion binding]; metal-binding site 264201000771 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264201000772 putative DNA binding site [nucleotide binding]; other site 264201000773 putative metal binding site [ion binding]; other site 264201000774 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 264201000775 active site 264201000776 catalytic site [active] 264201000777 substrate binding site [chemical binding]; other site 264201000778 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264201000779 active site 264201000780 DNA binding site [nucleotide binding] 264201000781 catalytic site [active] 264201000782 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 264201000783 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264201000784 tandem repeat interface [polypeptide binding]; other site 264201000785 oligomer interface [polypeptide binding]; other site 264201000786 active site residues [active] 264201000787 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 264201000788 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264201000789 FAD binding domain; Region: FAD_binding_1; pfam00667 264201000790 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 264201000791 FAD binding pocket [chemical binding]; other site 264201000792 FAD binding motif [chemical binding]; other site 264201000793 catalytic residues [active] 264201000794 NAD binding pocket [chemical binding]; other site 264201000795 phosphate binding motif [ion binding]; other site 264201000796 beta-alpha-beta structure motif; other site 264201000797 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 264201000798 homotrimer interaction site [polypeptide binding]; other site 264201000799 zinc binding site [ion binding]; other site 264201000800 CDP-binding sites; other site 264201000801 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 264201000802 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264201000803 hinge; other site 264201000804 active site 264201000805 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264201000806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201000807 FeS/SAM binding site; other site 264201000808 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 264201000809 arginine-tRNA ligase; Region: PLN02286 264201000810 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264201000811 active site 264201000812 HIGH motif; other site 264201000813 KMSK motif region; other site 264201000814 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264201000815 tRNA binding surface [nucleotide binding]; other site 264201000816 anticodon binding site; other site 264201000817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264201000818 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 264201000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201000820 Walker A motif; other site 264201000821 ATP binding site [chemical binding]; other site 264201000822 Walker B motif; other site 264201000823 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264201000824 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 264201000825 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 264201000826 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 264201000827 G1 box; other site 264201000828 GTP/Mg2+ binding site [chemical binding]; other site 264201000829 Switch I region; other site 264201000830 G2 box; other site 264201000831 G3 box; other site 264201000832 Switch II region; other site 264201000833 G4 box; other site 264201000834 G5 box; other site 264201000835 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 264201000836 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264201000837 active site 264201000838 catalytic site [active] 264201000839 substrate binding site [chemical binding]; other site 264201000840 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 264201000841 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 264201000842 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 264201000843 active site 264201000844 multimer interface [polypeptide binding]; other site 264201000845 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 264201000846 predicted active site [active] 264201000847 catalytic triad [active] 264201000848 Phosphoglycerate kinase; Region: PGK; pfam00162 264201000849 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 264201000850 substrate binding site [chemical binding]; other site 264201000851 hinge regions; other site 264201000852 ADP binding site [chemical binding]; other site 264201000853 catalytic site [active] 264201000854 TLC ATP/ADP transporter; Region: TLC; pfam03219 264201000855 TLC ATP/ADP transporter; Region: TLC; pfam03219 264201000856 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264201000857 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 264201000858 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264201000859 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264201000860 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264201000861 HIGH motif; other site 264201000862 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264201000863 active site 264201000864 KMSKS motif; other site 264201000865 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264201000866 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264201000867 protein binding site [polypeptide binding]; other site 264201000868 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264201000869 Catalytic dyad [active] 264201000870 Helix-turn-helix domain; Region: HTH_17; cl17695 264201000871 Helix-turn-helix domain; Region: HTH_17; pfam12728 264201000872 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264201000873 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 264201000874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201000875 S-adenosylmethionine binding site [chemical binding]; other site 264201000876 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 264201000877 DHH family; Region: DHH; pfam01368 264201000878 DHHA1 domain; Region: DHHA1; pfam02272 264201000879 TLC ATP/ADP transporter; Region: TLC; pfam03219 264201000880 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 264201000881 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 264201000882 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264201000883 Protein export membrane protein; Region: SecD_SecF; pfam02355 264201000884 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 264201000885 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264201000886 Protein of unknown function (DUF971); Region: DUF971; pfam06155 264201000887 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264201000888 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 264201000889 intersubunit interface [polypeptide binding]; other site 264201000890 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 264201000891 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 264201000892 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264201000893 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264201000894 ABC-ATPase subunit interface; other site 264201000895 dimer interface [polypeptide binding]; other site 264201000896 putative PBP binding regions; other site 264201000897 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 264201000898 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 264201000899 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264201000900 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264201000901 ABC-ATPase subunit interface; other site 264201000902 dimer interface [polypeptide binding]; other site 264201000903 putative PBP binding regions; other site 264201000904 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 264201000905 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 264201000906 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 264201000907 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 264201000908 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264201000909 active site 264201000910 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264201000911 RIP metalloprotease RseP; Region: TIGR00054 264201000912 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264201000913 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 264201000914 putative substrate binding region [chemical binding]; other site 264201000915 Amino acid permease; Region: AA_permease_2; pfam13520 264201000916 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264201000917 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201000918 Leucine-rich repeats; other site 264201000919 Substrate binding site [chemical binding]; other site 264201000920 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 264201000921 Leucine-rich repeats; other site 264201000922 Substrate binding site [chemical binding]; other site 264201000923 Leucine rich repeat; Region: LRR_8; pfam13855 264201000924 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201000925 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 264201000926 DNA binding residues [nucleotide binding] 264201000927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264201000928 active site 264201000929 phosphorylation site [posttranslational modification] 264201000930 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264201000931 active site 264201000932 phosphorylation site [posttranslational modification] 264201000933 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264201000934 trimer interface [polypeptide binding]; other site 264201000935 active site 264201000936 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 264201000937 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 264201000938 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264201000939 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264201000940 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264201000941 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 264201000942 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264201000943 active site 264201000944 porphobilinogen deaminase; Provisional; Region: PRK01066 264201000945 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 264201000946 domain interfaces; other site 264201000947 active site 264201000948 DNA repair protein RadA; Provisional; Region: PRK11823 264201000949 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264201000950 Walker A motif/ATP binding site; other site 264201000951 ATP binding site [chemical binding]; other site 264201000952 Walker B motif; other site 264201000953 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 264201000954 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264201000955 dimerization interface [polypeptide binding]; other site 264201000956 active site 264201000957 metal binding site [ion binding]; metal-binding site 264201000958 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264201000959 dsRNA binding site [nucleotide binding]; other site 264201000960 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264201000961 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 264201000962 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 264201000963 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 264201000964 putative ligand binding site [chemical binding]; other site 264201000965 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264201000966 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264201000967 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264201000968 lipoyl attachment site [posttranslational modification]; other site 264201000969 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 264201000970 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264201000971 tetramer interface [polypeptide binding]; other site 264201000972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201000973 catalytic residue [active] 264201000974 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264201000975 tetramer interface [polypeptide binding]; other site 264201000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201000977 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 264201000978 catalytic residue [active] 264201000979 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 264201000980 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 264201000981 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264201000982 Soluble P-type ATPase [General function prediction only]; Region: COG4087 264201000983 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 264201000984 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 264201000985 HlyD family secretion protein; Region: HlyD_3; pfam13437 264201000986 Outer membrane efflux protein; Region: OEP; pfam02321 264201000987 Outer membrane efflux protein; Region: OEP; pfam02321 264201000988 Transposase; Region: HTH_Tnp_IS630; pfam01710 264201000989 Helix-turn-helix domain; Region: HTH_28; pfam13518 264201000990 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 264201000991 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 264201000992 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 264201000993 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 264201000994 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 264201000995 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264201000996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264201000997 active site 264201000998 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264201000999 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 264201001000 oligomer interface [polypeptide binding]; other site 264201001001 metal binding site [ion binding]; metal-binding site 264201001002 metal binding site [ion binding]; metal-binding site 264201001003 Cl binding site [ion binding]; other site 264201001004 aspartate ring; other site 264201001005 basic sphincter; other site 264201001006 putative hydrophobic gate; other site 264201001007 periplasmic entrance; other site 264201001008 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 264201001009 DnaA N-terminal domain; Region: DnaA_N; pfam11638 264201001010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201001011 Walker A motif; other site 264201001012 ATP binding site [chemical binding]; other site 264201001013 Walker B motif; other site 264201001014 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264201001015 DnaA box-binding interface [nucleotide binding]; other site 264201001016 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264201001017 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264201001018 inhibitor-cofactor binding pocket; inhibition site 264201001019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201001020 catalytic residue [active] 264201001021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201001022 binding surface 264201001023 TPR motif; other site 264201001024 TPR repeat; Region: TPR_11; pfam13414 264201001025 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 264201001026 MraW methylase family; Region: Methyltransf_5; cl17771 264201001027 hypothetical protein; Region: PHA02414 264201001028 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264201001029 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264201001030 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 264201001031 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264201001032 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264201001033 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264201001034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264201001035 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 264201001036 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264201001037 active site 264201001038 metal binding site [ion binding]; metal-binding site 264201001039 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201001040 Sel1 repeat; Region: Sel1; pfam08238 264201001041 Sel1-like repeats; Region: SEL1; smart00671 264201001042 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 264201001043 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 264201001044 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 264201001045 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264201001046 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264201001047 putative acyl-acceptor binding pocket; other site 264201001048 cytidylate kinase; Provisional; Region: cmk; PRK00023 264201001049 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264201001050 CMP-binding site; other site 264201001051 The sites determining sugar specificity; other site 264201001052 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 264201001053 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 264201001054 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 264201001055 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 264201001056 catalytic residue [active] 264201001057 putative FPP diphosphate binding site; other site 264201001058 putative FPP binding hydrophobic cleft; other site 264201001059 dimer interface [polypeptide binding]; other site 264201001060 putative IPP diphosphate binding site; other site 264201001061 GTP-binding protein LepA; Provisional; Region: PRK05433 264201001062 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264201001063 G1 box; other site 264201001064 putative GEF interaction site [polypeptide binding]; other site 264201001065 GTP/Mg2+ binding site [chemical binding]; other site 264201001066 Switch I region; other site 264201001067 G2 box; other site 264201001068 G3 box; other site 264201001069 Switch II region; other site 264201001070 G4 box; other site 264201001071 G5 box; other site 264201001072 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264201001073 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264201001074 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264201001075 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571 264201001076 GTPase interaction site [polypeptide binding]; other site 264201001077 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201001078 active site 264201001079 SWIB/MDM2 domain; Region: SWIB; pfam02201 264201001080 phosphodiesterase YaeI; Provisional; Region: PRK11340 264201001081 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264201001082 putative active site [active] 264201001083 putative metal binding site [ion binding]; other site 264201001084 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264201001085 substrate binding site; other site 264201001086 dimer interface; other site 264201001087 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264201001088 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264201001089 dimerization interface 3.5A [polypeptide binding]; other site 264201001090 active site 264201001091 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 264201001092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264201001093 motif II; other site 264201001094 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264201001095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264201001096 active site 264201001097 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 264201001098 putative active site [active] 264201001099 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201001100 BTB/POZ domain; Region: BTB; cl02518 264201001101 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201001102 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201001103 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201001104 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201001105 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201001106 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201001107 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 264201001108 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 264201001109 30S subunit binding site; other site 264201001110 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 264201001111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201001112 FeS/SAM binding site; other site 264201001113 Recombination protein O N terminal; Region: RecO_N; pfam11967 264201001114 DNA repair protein RecO; Region: reco; TIGR00613 264201001115 Recombination protein O C terminal; Region: RecO_C; pfam02565 264201001116 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 264201001117 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264201001118 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 264201001119 endonuclease IV; Provisional; Region: PRK01060 264201001120 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 264201001121 AP (apurinic/apyrimidinic) site pocket; other site 264201001122 DNA interaction; other site 264201001123 Metal-binding active site; metal-binding site 264201001124 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 264201001125 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 264201001126 putative dimer interface [polypeptide binding]; other site 264201001127 putative anticodon binding site; other site 264201001128 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 264201001129 homodimer interface [polypeptide binding]; other site 264201001130 motif 1; other site 264201001131 motif 2; other site 264201001132 active site 264201001133 motif 3; other site 264201001134 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 264201001135 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 264201001136 tRNA; other site 264201001137 putative tRNA binding site [nucleotide binding]; other site 264201001138 putative NADP binding site [chemical binding]; other site 264201001139 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 264201001140 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264201001141 NAD(P) binding site [chemical binding]; other site 264201001142 homodimer interface [polypeptide binding]; other site 264201001143 substrate binding site [chemical binding]; other site 264201001144 active site 264201001145 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 264201001146 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 264201001147 ATP binding site [chemical binding]; other site 264201001148 Mg2+ binding site [ion binding]; other site 264201001149 G-X-G motif; other site 264201001150 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264201001151 anchoring element; other site 264201001152 dimer interface [polypeptide binding]; other site 264201001153 ATP binding site [chemical binding]; other site 264201001154 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 264201001155 active site 264201001156 putative metal-binding site [ion binding]; other site 264201001157 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264201001158 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 264201001159 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 264201001160 CAP-like domain; other site 264201001161 active site 264201001162 primary dimer interface [polypeptide binding]; other site 264201001163 RecX family; Region: RecX; pfam02631 264201001164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264201001165 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264201001166 RNA binding surface [nucleotide binding]; other site 264201001167 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264201001168 active site 264201001169 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264201001170 putative active site [active] 264201001171 dimerization interface [polypeptide binding]; other site 264201001172 putative tRNAtyr binding site [nucleotide binding]; other site 264201001173 hypothetical protein; Provisional; Region: PRK01064 264201001174 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264201001175 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264201001176 catalytic center binding site [active] 264201001177 ATP binding site [chemical binding]; other site 264201001178 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264201001179 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 264201001180 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 264201001181 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 264201001182 Walker A/P-loop; other site 264201001183 ATP binding site [chemical binding]; other site 264201001184 Q-loop/lid; other site 264201001185 ABC transporter signature motif; other site 264201001186 Walker B; other site 264201001187 D-loop; other site 264201001188 H-loop/switch region; other site 264201001189 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264201001190 active site 264201001191 multimer interface [polypeptide binding]; other site 264201001192 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 264201001193 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264201001194 glutamine binding [chemical binding]; other site 264201001195 catalytic triad [active] 264201001196 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264201001197 active site 264201001198 multimer interface [polypeptide binding]; other site 264201001199 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264201001200 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264201001201 putative tRNA-binding site [nucleotide binding]; other site 264201001202 B3/4 domain; Region: B3_4; pfam03483 264201001203 tRNA synthetase B5 domain; Region: B5; smart00874 264201001204 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264201001205 dimer interface [polypeptide binding]; other site 264201001206 motif 1; other site 264201001207 motif 3; other site 264201001208 motif 2; other site 264201001209 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 264201001210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264201001211 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264201001212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264201001213 catalytic loop [active] 264201001214 iron binding site [ion binding]; other site 264201001215 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 264201001216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201001217 ATP binding site [chemical binding]; other site 264201001218 putative Mg++ binding site [ion binding]; other site 264201001219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201001220 nucleotide binding region [chemical binding]; other site 264201001221 ATP-binding site [chemical binding]; other site 264201001222 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 264201001223 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 264201001224 active site residue [active] 264201001225 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264201001226 catalytic residues [active] 264201001227 putative cation:proton antiport protein; Provisional; Region: PRK10669 264201001228 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264201001229 TrkA-N domain; Region: TrkA_N; pfam02254 264201001230 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 264201001231 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 264201001232 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 264201001233 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 264201001234 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264201001235 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264201001236 dimer interface [polypeptide binding]; other site 264201001237 anticodon binding site; other site 264201001238 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264201001239 homodimer interface [polypeptide binding]; other site 264201001240 motif 1; other site 264201001241 active site 264201001242 motif 2; other site 264201001243 GAD domain; Region: GAD; pfam02938 264201001244 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 264201001245 motif 3; other site 264201001246 histidyl-tRNA synthetase; Region: hisS; TIGR00442 264201001247 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 264201001248 dimer interface [polypeptide binding]; other site 264201001249 motif 1; other site 264201001250 active site 264201001251 motif 2; other site 264201001252 motif 3; other site 264201001253 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264201001254 anticodon binding site; other site 264201001255 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264201001256 phosphopeptide binding site; other site 264201001257 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 264201001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201001259 putative substrate translocation pore; other site 264201001260 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 264201001261 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 264201001262 active site 264201001263 PHP Thumb interface [polypeptide binding]; other site 264201001264 metal binding site [ion binding]; metal-binding site 264201001265 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264201001266 generic binding surface I; other site 264201001267 generic binding surface II; other site 264201001268 TPR repeat; Region: TPR_11; pfam13414 264201001269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201001270 binding surface 264201001271 TPR motif; other site 264201001272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201001273 binding surface 264201001274 TPR motif; other site 264201001275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264201001276 binding surface 264201001277 TPR motif; other site 264201001278 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 264201001279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264201001280 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264201001281 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 264201001282 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 264201001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201001284 S-adenosylmethionine binding site [chemical binding]; other site 264201001285 16S rRNA methyltransferase B; Provisional; Region: PRK14902 264201001286 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 264201001287 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 264201001288 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264201001289 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264201001290 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 264201001291 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264201001292 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264201001293 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201001294 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201001295 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 264201001296 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 264201001297 putative active site [active] 264201001298 catalytic triad [active] 264201001299 putative dimer interface [polypeptide binding]; other site 264201001300 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 264201001301 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 264201001302 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264201001303 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264201001304 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 264201001305 active site 264201001306 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264201001307 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264201001308 putative active site [active] 264201001309 substrate binding site [chemical binding]; other site 264201001310 putative cosubstrate binding site; other site 264201001311 catalytic site [active] 264201001312 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264201001313 substrate binding site [chemical binding]; other site 264201001314 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201001315 SLBB domain; Region: SLBB; pfam10531 264201001316 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 264201001317 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 264201001318 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 264201001319 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264201001320 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264201001321 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264201001322 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 264201001323 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264201001324 putative translocon binding site; other site 264201001325 protein-rRNA interface [nucleotide binding]; other site 264201001326 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 264201001327 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264201001328 G-X-X-G motif; other site 264201001329 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264201001330 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264201001331 23S rRNA interface [nucleotide binding]; other site 264201001332 5S rRNA interface [nucleotide binding]; other site 264201001333 putative antibiotic binding site [chemical binding]; other site 264201001334 L25 interface [polypeptide binding]; other site 264201001335 L27 interface [polypeptide binding]; other site 264201001336 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264201001337 23S rRNA interface [nucleotide binding]; other site 264201001338 putative translocon interaction site; other site 264201001339 signal recognition particle (SRP54) interaction site; other site 264201001340 L23 interface [polypeptide binding]; other site 264201001341 trigger factor interaction site; other site 264201001342 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 264201001343 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 264201001344 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 264201001345 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 264201001346 RNA binding site [nucleotide binding]; other site 264201001347 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264201001348 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264201001349 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264201001350 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 264201001351 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264201001352 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264201001353 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264201001354 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264201001355 5S rRNA interface [nucleotide binding]; other site 264201001356 23S rRNA interface [nucleotide binding]; other site 264201001357 L5 interface [polypeptide binding]; other site 264201001358 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264201001359 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264201001360 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264201001361 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 264201001362 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264201001363 SecY translocase; Region: SecY; pfam00344 264201001364 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264201001365 30S ribosomal protein S13; Region: bact_S13; TIGR03631 264201001366 30S ribosomal protein S11; Validated; Region: PRK05309 264201001367 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264201001368 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264201001369 alphaNTD homodimer interface [polypeptide binding]; other site 264201001370 alphaNTD - beta interaction site [polypeptide binding]; other site 264201001371 alphaNTD - beta' interaction site [polypeptide binding]; other site 264201001372 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 264201001373 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 264201001374 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 264201001375 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 264201001376 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264201001377 CAAX protease self-immunity; Region: Abi; pfam02517 264201001378 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 264201001379 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264201001380 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264201001381 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264201001382 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 264201001383 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264201001384 oligomer interface [polypeptide binding]; other site 264201001385 active site residues [active] 264201001386 serine hydroxymethyltransferase; Provisional; Region: PRK13580 264201001387 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264201001388 dimer interface [polypeptide binding]; other site 264201001389 active site 264201001390 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264201001391 folate binding site [chemical binding]; other site 264201001392 Starch binding domain; Region: CBM_2; smart01065 264201001393 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 264201001394 Putative zinc ribbon domain; Region: DUF164; pfam02591 264201001395 CAAX protease self-immunity; Region: Abi; pfam02517 264201001396 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 264201001397 GTP cyclohydrolase I; Provisional; Region: PLN03044 264201001398 active site 264201001399 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264201001400 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264201001401 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201001402 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201001403 ABC transporter; Region: ABC_tran_2; pfam12848 264201001404 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201001405 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264201001406 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 264201001407 putative metal binding site; other site 264201001408 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 264201001409 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 264201001410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201001411 dimer interface [polypeptide binding]; other site 264201001412 conserved gate region; other site 264201001413 ABC-ATPase subunit interface; other site 264201001414 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 264201001415 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 264201001416 Walker A/P-loop; other site 264201001417 ATP binding site [chemical binding]; other site 264201001418 Q-loop/lid; other site 264201001419 ABC transporter signature motif; other site 264201001420 Walker B; other site 264201001421 D-loop; other site 264201001422 H-loop/switch region; other site 264201001423 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 264201001424 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264201001425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264201001426 active site 264201001427 DNA binding site [nucleotide binding] 264201001428 Int/Topo IB signature motif; other site 264201001429 ribonuclease Z; Region: RNase_Z; TIGR02651 264201001430 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 264201001431 Rhomboid family; Region: Rhomboid; pfam01694 264201001432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264201001433 active site 264201001434 nucleotide binding site [chemical binding]; other site 264201001435 HIGH motif; other site 264201001436 KMSKS motif; other site 264201001437 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264201001438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201001439 Walker A motif; other site 264201001440 ATP binding site [chemical binding]; other site 264201001441 Walker B motif; other site 264201001442 arginine finger; other site 264201001443 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264201001444 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 264201001445 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264201001446 Zn2+ binding site [ion binding]; other site 264201001447 Mg2+ binding site [ion binding]; other site 264201001448 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264201001449 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264201001450 Glycoprotease family; Region: Peptidase_M22; pfam00814 264201001451 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 264201001452 chaperone protein DnaJ; Provisional; Region: PRK14284 264201001453 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264201001454 HSP70 interaction site [polypeptide binding]; other site 264201001455 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264201001456 Zn binding sites [ion binding]; other site 264201001457 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264201001458 dimer interface [polypeptide binding]; other site 264201001459 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 264201001460 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 264201001461 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 264201001462 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 264201001463 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 264201001464 Bacitracin resistance protein BacA; Region: BacA; pfam02673 264201001465 Competence protein; Region: Competence; pfam03772 264201001466 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 264201001467 HPr kinase/phosphorylase; Provisional; Region: PRK05428 264201001468 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 264201001469 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 264201001470 Hpr binding site; other site 264201001471 active site 264201001472 homohexamer subunit interaction site [polypeptide binding]; other site 264201001473 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264201001474 dimerization domain swap beta strand [polypeptide binding]; other site 264201001475 regulatory protein interface [polypeptide binding]; other site 264201001476 active site 264201001477 regulatory phosphorylation site [posttranslational modification]; other site 264201001478 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 264201001479 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 264201001480 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 264201001481 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 264201001482 hypothetical protein; Validated; Region: PRK00153 264201001483 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 264201001484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201001485 Walker A motif; other site 264201001486 ATP binding site [chemical binding]; other site 264201001487 Walker B motif; other site 264201001488 arginine finger; other site 264201001489 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264201001490 RmuC family; Region: RmuC; pfam02646 264201001491 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264201001492 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 264201001493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201001494 Walker A motif; other site 264201001495 ATP binding site [chemical binding]; other site 264201001496 Walker B motif; other site 264201001497 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 264201001498 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264201001499 dinuclear metal binding motif [ion binding]; other site 264201001500 Bacterial SH3 domain homologues; Region: SH3b; smart00287 264201001501 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 264201001502 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 264201001503 putative active site [active] 264201001504 PhoH-like protein; Region: PhoH; pfam02562 264201001505 TLC ATP/ADP transporter; Region: TLC; cl03940 264201001506 MepB protein; Region: MepB; pfam08877 264201001507 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 264201001508 nudix motif; other site 264201001509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264201001510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264201001511 Coenzyme A binding pocket [chemical binding]; other site 264201001512 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264201001513 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 264201001514 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 264201001515 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 264201001516 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264201001517 HIGH motif; other site 264201001518 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264201001519 active site 264201001520 KMSKS motif; other site 264201001521 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 264201001522 tRNA binding surface [nucleotide binding]; other site 264201001523 anticodon binding site; other site 264201001524 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264201001525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 264201001526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264201001527 Catalytic site [active] 264201001528 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264201001529 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 264201001530 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 264201001531 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 264201001532 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 264201001533 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264201001534 Uncharacterized conserved protein [Function unknown]; Region: COG3189 264201001535 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 264201001536 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264201001537 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264201001538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201001539 Walker A/P-loop; other site 264201001540 ATP binding site [chemical binding]; other site 264201001541 Q-loop/lid; other site 264201001542 ABC transporter signature motif; other site 264201001543 Walker B; other site 264201001544 D-loop; other site 264201001545 H-loop/switch region; other site 264201001546 ABC transporter; Region: ABC_tran_2; pfam12848 264201001547 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201001548 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 264201001549 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264201001550 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 264201001551 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 264201001552 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 264201001553 trimer interface [polypeptide binding]; other site 264201001554 active site 264201001555 substrate binding site [chemical binding]; other site 264201001556 CoA binding site [chemical binding]; other site 264201001557 Fic/DOC family; Region: Fic; pfam02661 264201001558 YfdX protein; Region: YfdX; pfam10938 264201001559 Transposase; Region: HTH_Tnp_1; cl17663 264201001560 HTH-like domain; Region: HTH_21; pfam13276 264201001561 Integrase core domain; Region: rve; pfam00665 264201001562 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 264201001563 Chloramphenicol (Cm) binding site [chemical binding]; other site 264201001564 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264201001565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 264201001566 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264201001567 active site 264201001568 catalytic residues [active] 264201001569 metal binding site [ion binding]; metal-binding site 264201001570 thioesterase domain, putative; Region: yiiD_Cterm; TIGR02447 264201001571 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264201001572 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264201001573 active site 264201001574 catalytic tetrad [active] 264201001575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201001576 putative substrate translocation pore; other site 264201001577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264201001578 methionine aminopeptidase; Provisional; Region: PRK08671 264201001579 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 264201001580 active site 264201001581 RF-1 domain; Region: RF-1; pfam00472 264201001582 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264201001583 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264201001584 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264201001585 HlyD family secretion protein; Region: HlyD_3; pfam13437 264201001586 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264201001587 Protein export membrane protein; Region: SecD_SecF; cl14618 264201001588 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264201001589 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264201001590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264201001591 motif II; other site 264201001592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201001593 active site 264201001594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264201001595 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264201001596 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264201001597 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 264201001598 putative NAD(P) binding site [chemical binding]; other site 264201001599 active site 264201001600 putative substrate binding site [chemical binding]; other site 264201001601 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 264201001602 NADH dehydrogenase subunit B; Validated; Region: PRK06411 264201001603 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 264201001604 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 264201001605 NADH dehydrogenase subunit D; Validated; Region: PRK06075 264201001606 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 264201001607 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264201001608 putative dimer interface [polypeptide binding]; other site 264201001609 [2Fe-2S] cluster binding site [ion binding]; other site 264201001610 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264201001611 SLBB domain; Region: SLBB; pfam10531 264201001612 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 264201001613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264201001614 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 264201001615 catalytic loop [active] 264201001616 iron binding site [ion binding]; other site 264201001617 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 264201001618 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264201001619 molybdopterin cofactor binding site; other site 264201001620 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 264201001621 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 264201001622 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 264201001623 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 264201001624 4Fe-4S binding domain; Region: Fer4; pfam00037 264201001625 4Fe-4S binding domain; Region: Fer4; pfam00037 264201001626 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 264201001627 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 264201001628 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264201001629 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264201001630 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264201001631 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264201001632 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264201001633 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264201001634 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 264201001635 Peptidase family M48; Region: Peptidase_M48; pfam01435 264201001636 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 264201001637 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264201001638 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 264201001639 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 264201001640 nucleotide binding site/active site [active] 264201001641 HIT family signature motif; other site 264201001642 catalytic residue [active] 264201001643 Isochorismatase family; Region: Isochorismatase; pfam00857 264201001644 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 264201001645 catalytic triad [active] 264201001646 conserved cis-peptide bond; other site 264201001647 HEAT repeats; Region: HEAT_2; pfam13646 264201001648 HEAT repeats; Region: HEAT_2; pfam13646 264201001649 HEAT repeats; Region: HEAT_2; pfam13646 264201001650 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264201001651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201001652 dimer interface [polypeptide binding]; other site 264201001653 conserved gate region; other site 264201001654 ABC-ATPase subunit interface; other site 264201001655 NMT1/THI5 like; Region: NMT1; pfam09084 264201001656 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264201001657 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 264201001658 active site 264201001659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264201001660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201001661 Walker A/P-loop; other site 264201001662 ATP binding site [chemical binding]; other site 264201001663 Q-loop/lid; other site 264201001664 ABC transporter signature motif; other site 264201001665 Walker B; other site 264201001666 D-loop; other site 264201001667 H-loop/switch region; other site 264201001668 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 264201001669 aromatic amino acid transport protein; Region: araaP; TIGR00837 264201001670 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 264201001671 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 264201001672 nucleotide binding site [chemical binding]; other site 264201001673 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264201001674 SBD interface [polypeptide binding]; other site 264201001675 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 264201001676 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264201001677 rRNA binding site [nucleotide binding]; other site 264201001678 predicted 30S ribosome binding site; other site 264201001679 elongation factor Tu; Reviewed; Region: PRK12735 264201001680 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264201001681 G1 box; other site 264201001682 GEF interaction site [polypeptide binding]; other site 264201001683 GTP/Mg2+ binding site [chemical binding]; other site 264201001684 Switch I region; other site 264201001685 G2 box; other site 264201001686 G3 box; other site 264201001687 Switch II region; other site 264201001688 G4 box; other site 264201001689 G5 box; other site 264201001690 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264201001691 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264201001692 Antibiotic Binding Site [chemical binding]; other site 264201001693 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 264201001694 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 264201001695 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264201001696 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264201001697 putative homodimer interface [polypeptide binding]; other site 264201001698 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 264201001699 heterodimer interface [polypeptide binding]; other site 264201001700 homodimer interface [polypeptide binding]; other site 264201001701 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264201001702 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264201001703 23S rRNA interface [nucleotide binding]; other site 264201001704 L7/L12 interface [polypeptide binding]; other site 264201001705 putative thiostrepton binding site; other site 264201001706 L25 interface [polypeptide binding]; other site 264201001707 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264201001708 mRNA/rRNA interface [nucleotide binding]; other site 264201001709 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264201001710 23S rRNA interface [nucleotide binding]; other site 264201001711 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264201001712 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264201001713 core dimer interface [polypeptide binding]; other site 264201001714 peripheral dimer interface [polypeptide binding]; other site 264201001715 L10 interface [polypeptide binding]; other site 264201001716 L11 interface [polypeptide binding]; other site 264201001717 putative EF-Tu interaction site [polypeptide binding]; other site 264201001718 putative EF-G interaction site [polypeptide binding]; other site 264201001719 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 264201001720 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 264201001721 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 264201001722 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 264201001723 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264201001724 RPB11 interaction site [polypeptide binding]; other site 264201001725 RPB12 interaction site [polypeptide binding]; other site 264201001726 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264201001727 RPB3 interaction site [polypeptide binding]; other site 264201001728 RPB1 interaction site [polypeptide binding]; other site 264201001729 RPB11 interaction site [polypeptide binding]; other site 264201001730 RPB10 interaction site [polypeptide binding]; other site 264201001731 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264201001732 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 264201001733 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 264201001734 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264201001735 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264201001736 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264201001737 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 264201001738 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264201001739 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264201001740 DNA binding site [nucleotide binding] 264201001741 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264201001742 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 264201001743 Organic solvent tolerance protein; Region: OstA_C; pfam04453 264201001744 HEAT repeats; Region: HEAT_2; pfam13646 264201001745 HEAT repeats; Region: HEAT_2; pfam13646 264201001746 Maf-like protein; Region: Maf; pfam02545 264201001747 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264201001748 active site 264201001749 dimer interface [polypeptide binding]; other site 264201001750 Domain of unknown function DUF11; Region: DUF11; pfam01345 264201001751 Domain of unknown function DUF11; Region: DUF11; cl17728 264201001752 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 264201001753 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 264201001754 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 264201001755 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 264201001756 TPP-binding site; other site 264201001757 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264201001758 PYR/PP interface [polypeptide binding]; other site 264201001759 dimer interface [polypeptide binding]; other site 264201001760 TPP binding site [chemical binding]; other site 264201001761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264201001762 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 264201001763 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264201001764 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264201001765 generic binding surface II; other site 264201001766 generic binding surface I; other site 264201001767 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264201001768 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 264201001769 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 264201001770 Active_site [active] 264201001771 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 264201001772 YtxH-like protein; Region: YtxH; pfam12732 264201001773 YtxH-like protein; Region: YtxH; cl02079 264201001774 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 264201001775 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 264201001776 active site 264201001777 Zn binding site [ion binding]; other site 264201001778 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 264201001779 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264201001780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264201001781 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 264201001782 active site 264201001783 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264201001784 dimer interface [polypeptide binding]; other site 264201001785 substrate binding site [chemical binding]; other site 264201001786 catalytic residues [active] 264201001787 CsbD-like; Region: CsbD; cl17424 264201001788 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264201001789 Protein export membrane protein; Region: SecD_SecF; cl14618 264201001790 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264201001791 HlyD family secretion protein; Region: HlyD_3; pfam13437 264201001792 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264201001793 Predicted permeases [General function prediction only]; Region: COG0795 264201001794 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264201001795 Predicted permeases [General function prediction only]; Region: COG0795 264201001796 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264201001797 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264201001798 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264201001799 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 264201001800 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264201001801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201001802 Walker A motif; other site 264201001803 ATP binding site [chemical binding]; other site 264201001804 Walker B motif; other site 264201001805 arginine finger; other site 264201001806 Peptidase family M41; Region: Peptidase_M41; pfam01434 264201001807 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264201001808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264201001809 active site 264201001810 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264201001811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264201001812 active site 264201001813 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264201001814 RNase E interface [polypeptide binding]; other site 264201001815 polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591 264201001816 trimer interface [polypeptide binding]; other site 264201001817 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264201001818 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264201001819 RNase E interface [polypeptide binding]; other site 264201001820 trimer interface [polypeptide binding]; other site 264201001821 active site 264201001822 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264201001823 putative nucleic acid binding region [nucleotide binding]; other site 264201001824 G-X-X-G motif; other site 264201001825 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264201001826 RNA binding site [nucleotide binding]; other site 264201001827 domain interface; other site 264201001828 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264201001829 16S/18S rRNA binding site [nucleotide binding]; other site 264201001830 S13e-L30e interaction site [polypeptide binding]; other site 264201001831 25S rRNA binding site [nucleotide binding]; other site 264201001832 DDE superfamily endonuclease; Region: DDE_3; pfam13358 264201001833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 264201001834 Transposase; Region: HTH_Tnp_IS630; pfam01710 264201001835 Homeodomain-like domain; Region: HTH_23; cl17451 264201001836 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264201001837 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264201001838 nucleoside/Zn binding site; other site 264201001839 dimer interface [polypeptide binding]; other site 264201001840 catalytic motif [active] 264201001841 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 264201001842 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264201001843 PCRF domain; Region: PCRF; pfam03462 264201001844 RF-1 domain; Region: RF-1; pfam00472 264201001845 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 264201001846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201001847 S-adenosylmethionine binding site [chemical binding]; other site 264201001848 signal recognition particle protein; Provisional; Region: PRK10867 264201001849 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 264201001850 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264201001851 P loop; other site 264201001852 GTP binding site [chemical binding]; other site 264201001853 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264201001854 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 264201001855 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 264201001856 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 264201001857 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264201001858 RNA/DNA hybrid binding site [nucleotide binding]; other site 264201001859 active site 264201001860 hypothetical protein; Provisional; Region: PRK11820 264201001861 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264201001862 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264201001863 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264201001864 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264201001865 catalytic site [active] 264201001866 G-X2-G-X-G-K; other site 264201001867 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 264201001868 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 264201001869 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264201001870 active site 264201001871 HIGH motif; other site 264201001872 KMSKS motif; other site 264201001873 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264201001874 tRNA binding surface [nucleotide binding]; other site 264201001875 anticodon binding site; other site 264201001876 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264201001877 dimer interface [polypeptide binding]; other site 264201001878 putative tRNA-binding site [nucleotide binding]; other site 264201001879 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 264201001880 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264201001881 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264201001882 GatB domain; Region: GatB_Yqey; pfam02637 264201001883 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264201001884 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 264201001885 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 264201001886 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 264201001887 DNA photolyase; Region: DNA_photolyase; pfam00875 264201001888 TIGR01777 family protein; Region: yfcH 264201001889 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 264201001890 putative NAD(P) binding site [chemical binding]; other site 264201001891 putative active site [active] 264201001892 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201001893 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 264201001894 substrate binding site [chemical binding]; other site 264201001895 heme binding site [chemical binding]; other site 264201001896 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 264201001897 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 264201001898 active site 264201001899 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 264201001900 active site 264201001901 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264201001902 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264201001903 Walker A/P-loop; other site 264201001904 ATP binding site [chemical binding]; other site 264201001905 Q-loop/lid; other site 264201001906 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 264201001907 ABC transporter signature motif; other site 264201001908 Walker B; other site 264201001909 D-loop; other site 264201001910 H-loop/switch region; other site 264201001911 ribonuclease HIII; Provisional; Region: PRK00996 264201001912 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 264201001913 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 264201001914 RNA/DNA hybrid binding site [nucleotide binding]; other site 264201001915 active site 264201001916 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 264201001917 Helix-turn-helix domain; Region: HTH_25; pfam13413 264201001918 Domain of unknown function (DUF368); Region: DUF368; pfam04018 264201001919 Domain of unknown function (DUF368); Region: DUF368; pfam04018 264201001920 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264201001921 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264201001922 dimerization interface 3.5A [polypeptide binding]; other site 264201001923 active site 264201001924 MarC family integral membrane protein; Region: MarC; cl00919 264201001925 MarC family integral membrane protein; Region: MarC; pfam01914 264201001926 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 264201001927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264201001928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201001929 homodimer interface [polypeptide binding]; other site 264201001930 catalytic residue [active] 264201001931 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264201001932 dihydrodipicolinate synthase; Region: dapA; TIGR00674 264201001933 dimer interface [polypeptide binding]; other site 264201001934 active site 264201001935 catalytic residue [active] 264201001936 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264201001937 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 264201001938 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264201001939 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 264201001940 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 264201001941 putative active site [active] 264201001942 catalytic site [active] 264201001943 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264201001944 putative active site [active] 264201001945 catalytic site [active] 264201001946 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 264201001947 AAA domain; Region: AAA_30; pfam13604 264201001948 Family description; Region: UvrD_C_2; pfam13538 264201001949 DNA primase; Validated; Region: dnaG; PRK05667 264201001950 CHC2 zinc finger; Region: zf-CHC2; pfam01807 264201001951 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264201001952 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264201001953 active site 264201001954 metal binding site [ion binding]; metal-binding site 264201001955 interdomain interaction site; other site 264201001956 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264201001957 Protein of unknown function, DUF393; Region: DUF393; pfam04134 264201001958 glycyl-tRNA synthetase; Provisional; Region: PRK14908 264201001959 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 264201001960 dimer interface [polypeptide binding]; other site 264201001961 motif 1; other site 264201001962 active site 264201001963 motif 2; other site 264201001964 motif 3; other site 264201001965 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264201001966 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 264201001967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201001968 FeS/SAM binding site; other site 264201001969 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264201001970 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264201001971 GIY-YIG motif/motif A; other site 264201001972 active site 264201001973 catalytic site [active] 264201001974 putative DNA binding site [nucleotide binding]; other site 264201001975 metal binding site [ion binding]; metal-binding site 264201001976 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264201001977 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 264201001978 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264201001979 motif 1; other site 264201001980 dimer interface [polypeptide binding]; other site 264201001981 active site 264201001982 motif 3; other site 264201001983 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 264201001984 anticodon binding site; other site 264201001985 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 264201001986 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 264201001987 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 264201001988 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 264201001989 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264201001990 23S rRNA binding site [nucleotide binding]; other site 264201001991 L21 binding site [polypeptide binding]; other site 264201001992 L13 binding site [polypeptide binding]; other site 264201001993 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264201001994 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264201001995 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264201001996 dimer interface [polypeptide binding]; other site 264201001997 motif 1; other site 264201001998 active site 264201001999 motif 2; other site 264201002000 motif 3; other site 264201002001 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264201002002 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264201002003 RNA binding surface [nucleotide binding]; other site 264201002004 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264201002005 active site 264201002006 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264201002007 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264201002008 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264201002009 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002010 Sel1-like repeats; Region: SEL1; smart00671 264201002011 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002012 Sel1-like repeats; Region: SEL1; smart00671 264201002013 Sel1-like repeats; Region: SEL1; smart00671 264201002014 Sel1-like repeats; Region: SEL1; smart00671 264201002015 Sel1-like repeats; Region: SEL1; smart00671 264201002016 Sel1-like repeats; Region: SEL1; smart00671 264201002017 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002018 Sel1-like repeats; Region: SEL1; smart00671 264201002019 Sel1-like repeats; Region: SEL1; smart00671 264201002020 Sel1 repeat; Region: Sel1; cl02723 264201002021 Sel1-like repeats; Region: SEL1; smart00671 264201002022 Sel1-like repeats; Region: SEL1; smart00671 264201002023 Sel1-like repeats; Region: SEL1; smart00671 264201002024 Sel1-like repeats; Region: SEL1; smart00671 264201002025 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002026 Sel1-like repeats; Region: SEL1; smart00671 264201002027 Sel1-like repeats; Region: SEL1; smart00671 264201002028 Sel1-like repeats; Region: SEL1; smart00671 264201002029 Sel1-like repeats; Region: SEL1; smart00671 264201002030 Sel1-like repeats; Region: SEL1; smart00671 264201002031 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002032 Sel1-like repeats; Region: SEL1; smart00671 264201002033 Sel1-like repeats; Region: SEL1; smart00671 264201002034 Sel1-like repeats; Region: SEL1; smart00671 264201002035 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002036 Sel1-like repeats; Region: SEL1; smart00671 264201002037 Sel1-like repeats; Region: SEL1; smart00671 264201002038 Sel1-like repeats; Region: SEL1; smart00671 264201002039 Sel1-like repeats; Region: SEL1; smart00671 264201002040 Sel1-like repeats; Region: SEL1; smart00671 264201002041 Sel1-like repeats; Region: SEL1; smart00671 264201002042 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201002043 Sel1-like repeats; Region: SEL1; smart00671 264201002044 Sel1-like repeats; Region: SEL1; smart00671 264201002045 Sel1-like repeats; Region: SEL1; smart00671 264201002046 Sel1-like repeats; Region: SEL1; smart00671 264201002047 Sel1-like repeats; Region: SEL1; smart00671 264201002048 Sel1-like repeats; Region: SEL1; smart00671 264201002049 Sel1-like repeats; Region: SEL1; smart00671 264201002050 Sel1-like repeats; Region: SEL1; smart00671 264201002051 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 264201002052 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264201002053 nudix motif; other site 264201002054 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 264201002055 homodimer interface [polypeptide binding]; other site 264201002056 MazG family protein; Region: mazG; TIGR00444 264201002057 metal binding site [ion binding]; metal-binding site 264201002058 CAAX protease self-immunity; Region: Abi; pfam02517 264201002059 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 264201002060 reactive center loop; other site 264201002061 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264201002062 Protein phosphatase 2C; Region: PP2C; pfam00481 264201002063 active site 264201002064 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 264201002065 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 264201002066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264201002067 catalytic residue [active] 264201002068 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264201002069 nudix motif; other site 264201002070 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 264201002071 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 264201002072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264201002073 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264201002074 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264201002075 Clp amino terminal domain; Region: Clp_N; pfam02861 264201002076 Clp amino terminal domain; Region: Clp_N; pfam02861 264201002077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201002078 Walker A motif; other site 264201002079 ATP binding site [chemical binding]; other site 264201002080 Walker B motif; other site 264201002081 arginine finger; other site 264201002082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201002083 Walker A motif; other site 264201002084 ATP binding site [chemical binding]; other site 264201002085 Walker B motif; other site 264201002086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264201002087 A Receptor for Ubiquitination Targets; Region: FBOX; smart00256 264201002088 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 264201002089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264201002090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264201002091 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264201002092 F-box-like; Region: F-box-like; cl02535 264201002093 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 264201002094 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264201002095 A Receptor for Ubiquitination Targets; Region: FBOX; smart00256 264201002096 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 264201002097 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264201002098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 264201002099 Walker A motif; other site 264201002100 ATP binding site [chemical binding]; other site 264201002101 Walker B motif; other site 264201002102 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 264201002103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 264201002104 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264201002105 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201002106 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201002107 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264201002108 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 264201002109 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 264201002110 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Region: PLN02925 264201002111 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264201002112 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 264201002113 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 264201002114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201002115 binding surface 264201002116 TPR motif; other site 264201002117 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201002118 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002119 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002120 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002121 4-alpha-glucanotransferase; Provisional; Region: PRK14508 264201002122 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 264201002123 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 264201002124 FHIPEP family; Region: FHIPEP; pfam00771 264201002125 type III secretion system protein; Validated; Region: PRK06298 264201002126 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 264201002127 GTP-binding protein YchF; Reviewed; Region: PRK09601 264201002128 YchF GTPase; Region: YchF; cd01900 264201002129 G1 box; other site 264201002130 GTP/Mg2+ binding site [chemical binding]; other site 264201002131 Switch I region; other site 264201002132 G2 box; other site 264201002133 Switch II region; other site 264201002134 G3 box; other site 264201002135 G4 box; other site 264201002136 G5 box; other site 264201002137 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 264201002138 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 264201002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264201002140 S-adenosylmethionine binding site [chemical binding]; other site 264201002141 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002142 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264201002143 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264201002144 active site 264201002145 Riboflavin kinase; Region: Flavokinase; pfam01687 264201002146 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 264201002147 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264201002148 RNA binding site [nucleotide binding]; other site 264201002149 active site 264201002150 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 264201002151 translation initiation factor IF-2; Validated; Region: infB; PRK05306 264201002152 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264201002153 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264201002154 G1 box; other site 264201002155 putative GEF interaction site [polypeptide binding]; other site 264201002156 GTP/Mg2+ binding site [chemical binding]; other site 264201002157 Switch I region; other site 264201002158 G2 box; other site 264201002159 G3 box; other site 264201002160 Switch II region; other site 264201002161 G4 box; other site 264201002162 G5 box; other site 264201002163 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264201002164 Translation-initiation factor 2; Region: IF-2; pfam11987 264201002165 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264201002166 transcription termination factor NusA; Region: NusA; TIGR01953 264201002167 NusA N-terminal domain; Region: NusA_N; pfam08529 264201002168 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264201002169 RNA binding site [nucleotide binding]; other site 264201002170 homodimer interface [polypeptide binding]; other site 264201002171 NusA-like KH domain; Region: KH_5; pfam13184 264201002172 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264201002173 G-X-X-G motif; other site 264201002174 Helix-hairpin-helix motif; Region: HHH; pfam00633 264201002175 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 264201002176 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264201002177 RNA binding site [nucleotide binding]; other site 264201002178 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264201002179 RNA binding site [nucleotide binding]; other site 264201002180 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264201002181 RNA binding site [nucleotide binding]; other site 264201002182 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264201002183 RNA binding site [nucleotide binding]; other site 264201002184 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264201002185 RNA binding site [nucleotide binding]; other site 264201002186 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264201002187 RNA binding site [nucleotide binding]; other site 264201002188 domain interface; other site 264201002189 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 264201002190 putative nucleotide binding site [chemical binding]; other site 264201002191 putative catalytic residues [active] 264201002192 putative Mg ion binding site [ion binding]; other site 264201002193 putative aspartate binding site [chemical binding]; other site 264201002194 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 264201002195 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 264201002196 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264201002197 substrate binding site [chemical binding]; other site 264201002198 hexamer interface [polypeptide binding]; other site 264201002199 metal binding site [ion binding]; metal-binding site 264201002200 elongation factor P; Provisional; Region: PRK12426 264201002201 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264201002202 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264201002203 RNA binding site [nucleotide binding]; other site 264201002204 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264201002205 RNA binding site [nucleotide binding]; other site 264201002206 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 264201002207 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264201002208 carboxyltransferase (CT) interaction site; other site 264201002209 biotinylation site [posttranslational modification]; other site 264201002210 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264201002211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264201002212 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264201002213 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 264201002214 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 264201002215 Uncharacterized conserved protein [Function unknown]; Region: COG1284 264201002216 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 264201002217 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 264201002218 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264201002219 methionine aminopeptidase; Provisional; Region: PRK12318 264201002220 SEC-C motif; Region: SEC-C; pfam02810 264201002221 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264201002222 active site 264201002223 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 264201002224 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264201002225 active site 264201002226 dimer interface [polypeptide binding]; other site 264201002227 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264201002228 dimer interface [polypeptide binding]; other site 264201002229 active site 264201002230 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264201002231 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 264201002232 active site 264201002233 Int/Topo IB signature motif; other site 264201002234 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 264201002235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201002236 binding surface 264201002237 TPR motif; other site 264201002238 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264201002239 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 264201002240 putative NAD(P) binding site [chemical binding]; other site 264201002241 putative substrate binding site [chemical binding]; other site 264201002242 catalytic Zn binding site [ion binding]; other site 264201002243 structural Zn binding site [ion binding]; other site 264201002244 dimer interface [polypeptide binding]; other site 264201002245 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 264201002246 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264201002247 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 264201002248 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264201002249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264201002250 catalytic residue [active] 264201002251 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 264201002252 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 264201002253 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 264201002254 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264201002255 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 264201002256 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 264201002257 amphipathic channel; other site 264201002258 Asn-Pro-Ala signature motifs; other site 264201002259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 264201002260 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201002261 F-box-like; Region: F-box-like; pfam12937 264201002262 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 264201002263 putative active site [active] 264201002264 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264201002265 triosephosphate isomerase; Provisional; Region: PRK14567 264201002266 substrate binding site [chemical binding]; other site 264201002267 dimer interface [polypeptide binding]; other site 264201002268 catalytic triad [active] 264201002269 Preprotein translocase SecG subunit; Region: SecG; pfam03840 264201002270 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264201002271 active site 264201002272 catalytic residues [active] 264201002273 metal binding site [ion binding]; metal-binding site 264201002274 conserved hypothetical protein; Region: TIGR03843 264201002275 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201002276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 264201002277 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264201002278 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264201002279 metal-binding site [ion binding] 264201002280 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264201002281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264201002282 motif II; other site 264201002283 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 264201002284 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264201002285 NAD(P) binding site [chemical binding]; other site 264201002286 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 264201002287 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 264201002288 substrate-cofactor binding pocket; other site 264201002289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201002290 catalytic residue [active] 264201002291 Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921 264201002292 putative active site [active] 264201002293 redox center [active] 264201002294 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 264201002295 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264201002296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264201002297 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264201002298 Walker A/P-loop; other site 264201002299 ATP binding site [chemical binding]; other site 264201002300 Q-loop/lid; other site 264201002301 ABC transporter signature motif; other site 264201002302 Walker B; other site 264201002303 D-loop; other site 264201002304 H-loop/switch region; other site 264201002305 FtsX-like permease family; Region: FtsX; pfam02687 264201002306 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 264201002307 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 264201002308 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 264201002309 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 264201002310 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 264201002311 putative active site [active] 264201002312 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 264201002313 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264201002314 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264201002315 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264201002316 K-Cl cotransporter; Region: 2a30; TIGR00930 264201002317 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 264201002318 CTP synthetase; Validated; Region: pyrG; PRK05380 264201002319 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264201002320 Catalytic site [active] 264201002321 active site 264201002322 UTP binding site [chemical binding]; other site 264201002323 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264201002324 active site 264201002325 putative oxyanion hole; other site 264201002326 catalytic triad [active] 264201002327 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 264201002328 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 264201002329 Ligand binding site; other site 264201002330 oligomer interface; other site 264201002331 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 264201002332 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 264201002333 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 264201002334 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 264201002335 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264201002336 Family of unknown function (DUF648); Region: DUF648; pfam04890 264201002337 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 264201002338 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 264201002339 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 264201002340 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264201002341 active site 264201002342 metal binding site [ion binding]; metal-binding site 264201002343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264201002344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 264201002345 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264201002346 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 264201002347 nucleophilic elbow; other site 264201002348 catalytic triad; other site 264201002349 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201002350 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201002351 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264201002352 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264201002353 Erythromycin esterase; Region: Erythro_esteras; cl17110 264201002354 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 264201002355 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264201002356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201002357 S-adenosylmethionine binding site [chemical binding]; other site 264201002358 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 264201002359 SEC-C motif; Region: SEC-C; pfam02810 264201002360 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 264201002361 Ligand Binding Site [chemical binding]; other site 264201002362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201002363 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264201002364 Walker A motif; other site 264201002365 ATP binding site [chemical binding]; other site 264201002366 Walker B motif; other site 264201002367 arginine finger; other site 264201002368 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 264201002369 aconitate hydratase-like protein; Provisional; Region: PTZ00092 264201002370 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 264201002371 substrate binding site [chemical binding]; other site 264201002372 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 264201002373 ligand binding site [chemical binding]; other site 264201002374 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 264201002375 substrate binding site [chemical binding]; other site 264201002376 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 264201002377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201002378 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201002379 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264201002380 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 264201002381 Walker A/P-loop; other site 264201002382 ATP binding site [chemical binding]; other site 264201002383 Q-loop/lid; other site 264201002384 ABC transporter signature motif; other site 264201002385 Walker B; other site 264201002386 D-loop; other site 264201002387 H-loop/switch region; other site 264201002388 TOBE domain; Region: TOBE_2; pfam08402 264201002389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201002390 dimer interface [polypeptide binding]; other site 264201002391 conserved gate region; other site 264201002392 putative PBP binding loops; other site 264201002393 ABC-ATPase subunit interface; other site 264201002394 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264201002395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201002396 dimer interface [polypeptide binding]; other site 264201002397 conserved gate region; other site 264201002398 putative PBP binding loops; other site 264201002399 ABC-ATPase subunit interface; other site 264201002400 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264201002401 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 264201002402 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 264201002403 MgtE intracellular N domain; Region: MgtE_N; pfam03448 264201002404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 264201002405 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264201002406 Divalent cation transporter; Region: MgtE; pfam01769 264201002407 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264201002408 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264201002409 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 264201002410 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264201002411 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264201002412 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264201002413 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 264201002414 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 264201002415 active site 264201002416 ADP/pyrophosphate binding site [chemical binding]; other site 264201002417 dimerization interface [polypeptide binding]; other site 264201002418 allosteric effector site; other site 264201002419 fructose-1,6-bisphosphate binding site; other site 264201002420 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 264201002421 active site 264201002422 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 264201002423 catalytic residue [active] 264201002424 dimer interface [polypeptide binding]; other site 264201002425 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264201002426 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264201002427 shikimate binding site; other site 264201002428 NAD(P) binding site [chemical binding]; other site 264201002429 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 264201002430 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 264201002431 hinge; other site 264201002432 active site 264201002433 shikimate kinase; Provisional; Region: PRK13947 264201002434 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264201002435 ADP binding site [chemical binding]; other site 264201002436 magnesium binding site [ion binding]; other site 264201002437 putative shikimate binding site; other site 264201002438 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 264201002439 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264201002440 Tetramer interface [polypeptide binding]; other site 264201002441 active site 264201002442 FMN-binding site [chemical binding]; other site 264201002443 Caspase domain; Region: Peptidase_C14; pfam00656 264201002444 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002445 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002446 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002447 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264201002448 homopentamer interface [polypeptide binding]; other site 264201002449 active site 264201002450 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 264201002451 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 264201002452 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264201002453 dimerization interface [polypeptide binding]; other site 264201002454 active site 264201002455 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264201002456 Lumazine binding domain; Region: Lum_binding; pfam00677 264201002457 Lumazine binding domain; Region: Lum_binding; pfam00677 264201002458 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264201002459 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264201002460 DNA binding site [nucleotide binding] 264201002461 catalytic residue [active] 264201002462 H2TH interface [polypeptide binding]; other site 264201002463 putative catalytic residues [active] 264201002464 turnover-facilitating residue; other site 264201002465 intercalation triad [nucleotide binding]; other site 264201002466 8OG recognition residue [nucleotide binding]; other site 264201002467 putative reading head residues; other site 264201002468 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264201002469 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264201002470 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 264201002471 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264201002472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264201002473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201002474 Walker A/P-loop; other site 264201002475 ATP binding site [chemical binding]; other site 264201002476 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 264201002477 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 264201002478 Peptidase family M48; Region: Peptidase_M48; cl12018 264201002479 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201002480 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264201002481 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264201002482 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264201002483 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 264201002484 Probable Catalytic site; other site 264201002485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264201002486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264201002487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201002488 active site 264201002489 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 264201002490 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264201002491 Probable Catalytic site; other site 264201002492 metal-binding site 264201002493 Predicted membrane protein [Function unknown]; Region: COG2259 264201002494 Cytochrome c [Energy production and conversion]; Region: COG3258 264201002495 Cytochrome c; Region: Cytochrom_C; pfam00034 264201002496 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 264201002497 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 264201002498 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264201002499 Cation efflux family; Region: Cation_efflux; pfam01545 264201002500 putative cation:proton antiport protein; Provisional; Region: PRK10669 264201002501 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 264201002502 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 264201002503 TrkA-N domain; Region: TrkA_N; pfam02254 264201002504 TrkA-C domain; Region: TrkA_C; pfam02080 264201002505 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264201002506 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 264201002507 active site triad [active] 264201002508 Fic family protein [Function unknown]; Region: COG3177 264201002509 Fic/DOC family; Region: Fic; pfam02661 264201002510 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 264201002511 homodimer interaction site [polypeptide binding]; other site 264201002512 cofactor binding site; other site 264201002513 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 264201002514 putative rRNA binding site [nucleotide binding]; other site 264201002515 Protein required for attachment to host cells; Region: Host_attach; pfam10116 264201002516 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 264201002517 amino acid transporter; Region: 2A0306; TIGR00909 264201002518 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 264201002519 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 264201002520 catalytic triad [active] 264201002521 Flagellin N-methylase; Region: FliB; pfam03692 264201002522 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 264201002523 active site clefts [active] 264201002524 zinc binding site [ion binding]; other site 264201002525 dimer interface [polypeptide binding]; other site 264201002526 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 264201002527 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264201002528 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 264201002529 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 264201002530 putative active site; other site 264201002531 catalytic residue [active] 264201002532 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264201002533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264201002534 motif II; other site 264201002535 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264201002536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264201002537 nucleotide binding site [chemical binding]; other site 264201002538 PKD domain; Region: PKD; pfam00801 264201002539 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 264201002540 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264201002541 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264201002542 active site residue [active] 264201002543 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264201002544 active site residue [active] 264201002545 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 264201002546 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264201002547 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264201002548 catalytic residues [active] 264201002549 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 264201002550 putative active site [active] 264201002551 putative metal binding site [ion binding]; other site 264201002552 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 264201002553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201002554 ATP binding site [chemical binding]; other site 264201002555 putative Mg++ binding site [ion binding]; other site 264201002556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201002557 nucleotide binding region [chemical binding]; other site 264201002558 ATP-binding site [chemical binding]; other site 264201002559 DEAD/H associated; Region: DEAD_assoc; pfam08494 264201002560 ATP-dependent DNA ligase; Validated; Region: PRK09247 264201002561 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 264201002562 active site 264201002563 DNA binding site [nucleotide binding] 264201002564 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 264201002565 DNA binding site [nucleotide binding] 264201002566 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 264201002567 short chain dehydrogenase; Provisional; Region: PRK06701 264201002568 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 264201002569 NAD binding site [chemical binding]; other site 264201002570 metal binding site [ion binding]; metal-binding site 264201002571 active site 264201002572 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 264201002573 dimerization interface [polypeptide binding]; other site 264201002574 metal binding site [ion binding]; metal-binding site 264201002575 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 264201002576 Ferritin-like domain; Region: Ferritin; pfam00210 264201002577 ferroxidase diiron center [ion binding]; other site 264201002578 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264201002579 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264201002580 Methyltransferase domain; Region: Methyltransf_26; pfam13659 264201002581 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264201002582 trimer interface [polypeptide binding]; other site 264201002583 active site 264201002584 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 264201002585 GIY-YIG motif/motif A; other site 264201002586 putative active site [active] 264201002587 putative metal binding site [ion binding]; other site 264201002588 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201002589 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264201002590 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 264201002591 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 264201002592 methionine sulfoxide reductase A; Provisional; Region: PRK14054 264201002593 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201002594 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264201002595 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201002596 Leucine-rich repeats; other site 264201002597 Substrate binding site [chemical binding]; other site 264201002598 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201002599 Predicted flavoprotein [General function prediction only]; Region: COG0431 264201002600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264201002601 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264201002602 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264201002603 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 264201002604 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264201002605 RNA binding site [nucleotide binding]; other site 264201002606 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 264201002607 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264201002608 active site 264201002609 DNA binding site [nucleotide binding] 264201002610 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 264201002611 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 264201002612 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264201002613 Catalytic site [active] 264201002614 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 264201002615 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 264201002616 heme-binding site [chemical binding]; other site 264201002617 Transmembrane proteins 14C; Region: Tmemb_14; pfam03647 264201002618 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 264201002619 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264201002620 TraE protein; Region: TraE; cl05060 264201002621 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 264201002622 Transposase; Region: HTH_Tnp_1; pfam01527 264201002623 Integrase core domain; Region: rve; pfam00665 264201002624 ParG; Region: ParG; pfam09274 264201002625 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 264201002626 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002627 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002628 BTB/POZ domain; Region: BTB; cl02518 264201002629 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002630 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264201002631 DNA binding site [nucleotide binding] 264201002632 active site 264201002633 Int/Topo IB signature motif; other site 264201002634 catalytic residues [active] 264201002635 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 264201002636 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 264201002637 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264201002638 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002639 HTH-like domain; Region: HTH_21; pfam13276 264201002640 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 264201002641 Integrase core domain; Region: rve; pfam00665 264201002642 Integrase core domain; Region: rve_3; pfam13683 264201002643 Transposase; Region: HTH_Tnp_1; cl17663 264201002644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264201002645 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 264201002646 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201002647 Transposase; Region: HTH_Tnp_1; pfam01527 264201002648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 264201002649 HTH-like domain; Region: HTH_21; pfam13276 264201002650 Integrase core domain; Region: rve; pfam00665 264201002651 Integrase core domain; Region: rve_3; pfam13683 264201002652 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264201002653 HI0933-like protein; Region: HI0933_like; pfam03486 264201002654 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264201002655 HI0933-like protein; Region: HI0933_like; pfam03486 264201002656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264201002657 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264201002658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201002659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201002660 ABC transporter; Region: ABC_tran_2; pfam12848 264201002661 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201002662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201002663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264201002664 non-specific DNA binding site [nucleotide binding]; other site 264201002665 salt bridge; other site 264201002666 sequence-specific DNA binding site [nucleotide binding]; other site 264201002667 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264201002668 Fic/DOC family; Region: Fic; cl00960 264201002669 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002670 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002671 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002672 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264201002673 DNA binding site [nucleotide binding] 264201002674 active site 264201002675 Int/Topo IB signature motif; other site 264201002676 Transposase; Region: HTH_Tnp_1; cl17663 264201002677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264201002678 HTH-like domain; Region: HTH_21; pfam13276 264201002679 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 264201002680 Integrase core domain; Region: rve; pfam00665 264201002681 Integrase core domain; Region: rve_3; pfam13683 264201002682 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002683 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002684 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002685 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201002686 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002687 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002688 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002689 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201002690 Leucine-rich repeats; other site 264201002691 Substrate binding site [chemical binding]; other site 264201002692 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002693 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002694 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264201002695 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264201002696 Magnesium ion binding site [ion binding]; other site 264201002697 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 264201002698 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264201002699 adenylate kinase; Reviewed; Region: adk; PRK00279 264201002700 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264201002701 AMP-binding site [chemical binding]; other site 264201002702 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264201002703 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 264201002704 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264201002705 catalytic motif [active] 264201002706 Zn binding site [ion binding]; other site 264201002707 RibD C-terminal domain; Region: RibD_C; cl17279 264201002708 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264201002709 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264201002710 putative RNA binding site [nucleotide binding]; other site 264201002711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201002712 S-adenosylmethionine binding site [chemical binding]; other site 264201002713 Protein of unknown function (DUF423); Region: DUF423; pfam04241 264201002714 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264201002715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201002716 S-adenosylmethionine binding site [chemical binding]; other site 264201002717 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264201002718 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264201002719 HIGH motif; other site 264201002720 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264201002721 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264201002722 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264201002723 active site 264201002724 KMSKS motif; other site 264201002725 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264201002726 tRNA binding surface [nucleotide binding]; other site 264201002727 ribonuclease R; Region: RNase_R; TIGR02063 264201002728 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 264201002729 RNB domain; Region: RNB; pfam00773 264201002730 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 264201002731 RNA binding site [nucleotide binding]; other site 264201002732 Uncharacterized conserved protein [Function unknown]; Region: COG2928 264201002733 Protein of unknown function (DUF502); Region: DUF502; cl01107 264201002734 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 264201002735 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 264201002736 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 264201002737 FOG: CBS domain [General function prediction only]; Region: COG0517 264201002738 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264201002739 Transporter associated domain; Region: CorC_HlyC; smart01091 264201002740 ribonuclease Y; Region: RNase_Y; TIGR03319 264201002741 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264201002742 Zn2+ binding site [ion binding]; other site 264201002743 Mg2+ binding site [ion binding]; other site 264201002744 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 264201002745 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 264201002746 active site clefts [active] 264201002747 zinc binding site [ion binding]; other site 264201002748 dimer interface [polypeptide binding]; other site 264201002749 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264201002750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201002751 S-adenosylmethionine binding site [chemical binding]; other site 264201002752 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264201002753 active site 264201002754 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264201002755 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 264201002756 AMP binding site [chemical binding]; other site 264201002757 active site 264201002758 acyl-activating enzyme (AAE) consensus motif; other site 264201002759 CoA binding site [chemical binding]; other site 264201002760 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 264201002761 UbiA prenyltransferase family; Region: UbiA; pfam01040 264201002762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264201002763 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264201002764 substrate binding site [chemical binding]; other site 264201002765 oxyanion hole (OAH) forming residues; other site 264201002766 trimer interface [polypeptide binding]; other site 264201002767 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201002768 Leucine-rich repeats; other site 264201002769 Substrate binding site [chemical binding]; other site 264201002770 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201002771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264201002772 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 264201002773 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 264201002774 dimer interface [polypeptide binding]; other site 264201002775 tetramer interface [polypeptide binding]; other site 264201002776 PYR/PP interface [polypeptide binding]; other site 264201002777 TPP binding site [chemical binding]; other site 264201002778 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 264201002779 TPP-binding site; other site 264201002780 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264201002781 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 264201002782 DNA polymerase III subunit delta'; Validated; Region: PRK08485 264201002783 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 264201002784 thymidylate kinase; Validated; Region: tmk; PRK00698 264201002785 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264201002786 TMP-binding site; other site 264201002787 ATP-binding site [chemical binding]; other site 264201002788 DNA gyrase subunit A; Validated; Region: PRK05560 264201002789 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 264201002790 CAP-like domain; other site 264201002791 active site 264201002792 primary dimer interface [polypeptide binding]; other site 264201002793 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264201002794 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264201002795 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264201002796 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264201002797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264201002798 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264201002799 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 264201002800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264201002801 ATP binding site [chemical binding]; other site 264201002802 Mg2+ binding site [ion binding]; other site 264201002803 G-X-G motif; other site 264201002804 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264201002805 anchoring element; other site 264201002806 dimer interface [polypeptide binding]; other site 264201002807 ATP binding site [chemical binding]; other site 264201002808 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264201002809 active site 264201002810 putative metal-binding site [ion binding]; other site 264201002811 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264201002812 Protein of unknown function (DUF721); Region: DUF721; pfam05258 264201002813 Autotransporter beta-domain; Region: Autotransporter; cl17461 264201002814 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 264201002815 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 264201002816 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 264201002817 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264201002818 active site 264201002819 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264201002820 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264201002821 active site 264201002822 ATP binding site [chemical binding]; other site 264201002823 substrate binding site [chemical binding]; other site 264201002824 activation loop (A-loop); other site 264201002825 Uncharacterized conserved protein [Function unknown]; Region: COG1262 264201002826 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 264201002827 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 264201002828 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 264201002829 chromosomal replication initiation protein; Provisional; Region: PRK12422 264201002830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201002831 Walker A motif; other site 264201002832 ATP binding site [chemical binding]; other site 264201002833 Walker B motif; other site 264201002834 arginine finger; other site 264201002835 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264201002836 DnaA box-binding interface [nucleotide binding]; other site 264201002837 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 264201002838 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264201002839 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 264201002840 catalytic loop [active] 264201002841 iron binding site [ion binding]; other site 264201002842 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 264201002843 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 264201002844 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201002845 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201002846 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 264201002847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264201002848 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264201002849 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 264201002850 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264201002851 E3 interaction surface; other site 264201002852 lipoyl attachment site [posttranslational modification]; other site 264201002853 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264201002854 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264201002855 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264201002856 TPP-binding site [chemical binding]; other site 264201002857 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 264201002858 dimer interface [polypeptide binding]; other site 264201002859 PYR/PP interface [polypeptide binding]; other site 264201002860 TPP binding site [chemical binding]; other site 264201002861 Dienelactone hydrolase family; Region: DLH; pfam01738 264201002862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 264201002863 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264201002864 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 264201002865 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 264201002866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201002867 FeS/SAM binding site; other site 264201002868 HemN C-terminal domain; Region: HemN_C; pfam06969 264201002869 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 264201002870 homodimer interface [polypeptide binding]; other site 264201002871 putative SAM binding site [chemical binding]; other site 264201002872 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264201002873 DNA polymerase III, delta subunit; Region: holA; TIGR01128 264201002874 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 264201002875 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 264201002876 multifunctional aminopeptidase A; Provisional; Region: PRK00913 264201002877 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 264201002878 interface (dimer of trimers) [polypeptide binding]; other site 264201002879 Substrate-binding/catalytic site; other site 264201002880 Zn-binding sites [ion binding]; other site 264201002881 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 264201002882 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264201002883 dimer interface [polypeptide binding]; other site 264201002884 ssDNA binding site [nucleotide binding]; other site 264201002885 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264201002886 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 264201002887 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 264201002888 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 264201002889 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 264201002890 active site 264201002891 catalytic site [active] 264201002892 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 264201002893 Stage II sporulation protein; Region: SpoIID; pfam08486 264201002894 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264201002895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201002896 Walker A motif; other site 264201002897 ATP binding site [chemical binding]; other site 264201002898 Walker B motif; other site 264201002899 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264201002900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201002901 binding surface 264201002902 TPR motif; other site 264201002903 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 264201002904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201002905 S-adenosylmethionine binding site [chemical binding]; other site 264201002906 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 264201002907 MgtE intracellular N domain; Region: MgtE_N; pfam03448 264201002908 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 264201002909 Divalent cation transporter; Region: MgtE; pfam01769 264201002910 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 264201002911 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264201002912 G1 box; other site 264201002913 putative GEF interaction site [polypeptide binding]; other site 264201002914 GTP/Mg2+ binding site [chemical binding]; other site 264201002915 Switch I region; other site 264201002916 G2 box; other site 264201002917 G3 box; other site 264201002918 Switch II region; other site 264201002919 G4 box; other site 264201002920 G5 box; other site 264201002921 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264201002922 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264201002923 TPR repeat; Region: TPR_11; pfam13414 264201002924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201002925 TPR motif; other site 264201002926 binding surface 264201002927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201002928 TPR motif; other site 264201002929 TPR repeat; Region: TPR_11; pfam13414 264201002930 binding surface 264201002931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201002932 binding surface 264201002933 TPR repeat; Region: TPR_11; pfam13414 264201002934 TPR motif; other site 264201002935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201002936 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 264201002937 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 264201002938 catalytic residues [active] 264201002939 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 264201002940 active site 264201002941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201002942 Domain of unknown function DUF21; Region: DUF21; pfam01595 264201002943 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 264201002944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264201002945 Transporter associated domain; Region: CorC_HlyC; smart01091 264201002946 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264201002947 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264201002948 catalytic residue [active] 264201002949 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 264201002950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201002951 Protein kinase domain; Region: Pkinase; pfam00069 264201002952 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264201002953 active site 264201002954 ATP binding site [chemical binding]; other site 264201002955 substrate binding site [chemical binding]; other site 264201002956 activation loop (A-loop); other site 264201002957 Haemolysin-III related; Region: HlyIII; cl03831 264201002958 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 264201002959 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 264201002960 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264201002961 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 264201002962 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 264201002963 cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain; Region: cyclophilin_WD40; cd01927 264201002964 active site 264201002965 Thioredoxin; Region: Thioredoxin_4; cl17273 264201002966 Predicted membrane protein [Function unknown]; Region: COG4129 264201002967 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 264201002968 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002969 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201002970 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 264201002971 DNA binding site [nucleotide binding] 264201002972 dimer interface [polypeptide binding]; other site 264201002973 active site 264201002974 Int/Topo IB signature motif; other site 264201002975 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 264201002976 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201002977 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201002978 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 264201002979 dimerization interface [polypeptide binding]; other site 264201002980 metal binding site [ion binding]; metal-binding site 264201002981 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264201002982 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 264201002983 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 264201002984 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264201002985 dimerization interface [polypeptide binding]; other site 264201002986 DPS ferroxidase diiron center [ion binding]; other site 264201002987 ion pore; other site 264201002988 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 264201002989 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06300 264201002990 NAD(P) binding site [chemical binding]; other site 264201002991 active site 264201002992 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 264201002993 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 264201002994 NADP binding site [chemical binding]; other site 264201002995 substrate binding pocket [chemical binding]; other site 264201002996 active site 264201002997 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 264201002998 nudix motif; other site 264201002999 Dihydroneopterin aldolase; Region: FolB; pfam02152 264201003000 active site 264201003001 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 264201003002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 264201003003 active site 264201003004 motif I; other site 264201003005 motif II; other site 264201003006 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 264201003007 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 264201003008 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 264201003009 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264201003010 active site 264201003011 substrate binding site [chemical binding]; other site 264201003012 catalytic site [active] 264201003013 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 264201003014 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 264201003015 putative NAD(P) binding site [chemical binding]; other site 264201003016 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 264201003017 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264201003018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264201003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201003020 Walker A/P-loop; other site 264201003021 ATP binding site [chemical binding]; other site 264201003022 Q-loop/lid; other site 264201003023 ABC transporter signature motif; other site 264201003024 Walker B; other site 264201003025 D-loop; other site 264201003026 H-loop/switch region; other site 264201003027 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 264201003028 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 264201003029 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 264201003030 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264201003031 IHF dimer interface [polypeptide binding]; other site 264201003032 IHF - DNA interface [nucleotide binding]; other site 264201003033 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264201003034 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264201003035 active site 264201003036 HIGH motif; other site 264201003037 dimer interface [polypeptide binding]; other site 264201003038 KMSKS motif; other site 264201003039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264201003040 RNA binding surface [nucleotide binding]; other site 264201003041 BON domain; Region: BON; pfam04972 264201003042 Uncharacterized conserved protein [Function unknown]; Region: COG0327 264201003043 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 264201003044 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 264201003045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264201003046 active site 264201003047 dimer interface [polypeptide binding]; other site 264201003048 Bifunctional nuclease; Region: DNase-RNase; pfam02577 264201003049 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264201003050 dimerization domain swap beta strand [polypeptide binding]; other site 264201003051 regulatory protein interface [polypeptide binding]; other site 264201003052 active site 264201003053 regulatory phosphorylation site [posttranslational modification]; other site 264201003054 oligoendopeptidase F; Region: pepF; TIGR00181 264201003055 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 264201003056 active site 264201003057 Zn binding site [ion binding]; other site 264201003058 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264201003059 oligomerisation interface [polypeptide binding]; other site 264201003060 mobile loop; other site 264201003061 roof hairpin; other site 264201003062 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264201003063 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264201003064 ring oligomerisation interface [polypeptide binding]; other site 264201003065 ATP/Mg binding site [chemical binding]; other site 264201003066 stacking interactions; other site 264201003067 hinge regions; other site 264201003068 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 264201003069 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 264201003070 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 264201003071 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 264201003072 active site 264201003073 DNA binding site [nucleotide binding] 264201003074 Int/Topo IB signature motif; other site 264201003075 catalytic residues [active] 264201003076 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264201003077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264201003078 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 264201003079 TspO/MBR family; Region: TspO_MBR; pfam03073 264201003080 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 264201003081 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 264201003082 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264201003083 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264201003084 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264201003085 D-pathway; other site 264201003086 Putative ubiquinol binding site [chemical binding]; other site 264201003087 Low-spin heme (heme b) binding site [chemical binding]; other site 264201003088 Putative water exit pathway; other site 264201003089 Binuclear center (heme o3/CuB) [ion binding]; other site 264201003090 K-pathway; other site 264201003091 Putative proton exit pathway; other site 264201003092 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264201003093 Subunit I/III interface [polypeptide binding]; other site 264201003094 Subunit III/IV interface [polypeptide binding]; other site 264201003095 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 264201003096 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 264201003097 UbiA prenyltransferase family; Region: UbiA; pfam01040 264201003098 A Receptor for Ubiquitination Targets; Region: FBOX; smart00256 264201003099 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264201003100 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003101 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264201003102 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003103 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003104 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003105 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003106 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003107 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264201003108 DNA binding site [nucleotide binding] 264201003109 active site 264201003110 Int/Topo IB signature motif; other site 264201003111 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264201003112 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003113 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264201003114 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003115 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003116 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264201003117 DNA binding site [nucleotide binding] 264201003118 Int/Topo IB signature motif; other site 264201003119 active site 264201003120 catalytic residues [active] 264201003121 Vps4 C terminal oligomerisation domain; Region: Vps4_C; pfam09336 264201003122 F-box-like; Region: F-box-like; pfam12937 264201003123 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 264201003124 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 264201003125 active site 264201003126 Mg2+ binding site [ion binding]; other site 264201003127 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 264201003128 active site 264201003129 Zn binding site [ion binding]; other site 264201003130 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003132 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 264201003133 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264201003134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 264201003135 FtsX-like permease family; Region: FtsX; pfam02687 264201003136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264201003137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 264201003138 Walker A/P-loop; other site 264201003139 ATP binding site [chemical binding]; other site 264201003140 Q-loop/lid; other site 264201003141 ABC transporter signature motif; other site 264201003142 Walker B; other site 264201003143 D-loop; other site 264201003144 H-loop/switch region; other site 264201003145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264201003146 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264201003147 Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222 264201003148 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264201003149 MutS domain I; Region: MutS_I; pfam01624 264201003150 MutS domain II; Region: MutS_II; pfam05188 264201003151 MutS domain III; Region: MutS_III; pfam05192 264201003152 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 264201003153 Walker A/P-loop; other site 264201003154 ATP binding site [chemical binding]; other site 264201003155 Q-loop/lid; other site 264201003156 ABC transporter signature motif; other site 264201003157 Walker B; other site 264201003158 D-loop; other site 264201003159 H-loop/switch region; other site 264201003160 primosome assembly protein PriA; Validated; Region: PRK05580 264201003161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201003162 ATP binding site [chemical binding]; other site 264201003163 putative Mg++ binding site [ion binding]; other site 264201003164 helicase superfamily c-terminal domain; Region: HELICc; smart00490 264201003165 ATP-binding site [chemical binding]; other site 264201003166 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 264201003167 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264201003168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201003169 FeS/SAM binding site; other site 264201003170 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264201003171 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264201003172 dimer interface [polypeptide binding]; other site 264201003173 putative anticodon binding site; other site 264201003174 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264201003175 motif 1; other site 264201003176 dimer interface [polypeptide binding]; other site 264201003177 active site 264201003178 motif 2; other site 264201003179 motif 3; other site 264201003180 transglutaminase; Provisional; Region: tgl; PRK03187 264201003181 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264201003182 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264201003183 active site 264201003184 HIGH motif; other site 264201003185 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264201003186 KMSKS motif; other site 264201003187 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264201003188 tRNA binding surface [nucleotide binding]; other site 264201003189 anticodon binding site; other site 264201003190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264201003191 putative acyl-acceptor binding pocket; other site 264201003192 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 264201003193 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 264201003194 acyl-activating enzyme (AAE) consensus motif; other site 264201003195 putative AMP binding site [chemical binding]; other site 264201003196 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264201003197 nudix motif; other site 264201003198 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 264201003199 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264201003200 dimer interface [polypeptide binding]; other site 264201003201 active site 264201003202 Oligomerisation domain; Region: Oligomerisation; pfam02410 264201003203 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 264201003204 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 264201003205 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264201003206 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264201003207 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 264201003208 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 264201003209 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 264201003210 active site 264201003211 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 264201003212 anti sigma factor interaction site; other site 264201003213 regulatory phosphorylation site [posttranslational modification]; other site 264201003214 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264201003215 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264201003216 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264201003217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201003218 Walker A/P-loop; other site 264201003219 ATP binding site [chemical binding]; other site 264201003220 Q-loop/lid; other site 264201003221 ABC transporter signature motif; other site 264201003222 Walker B; other site 264201003223 D-loop; other site 264201003224 H-loop/switch region; other site 264201003225 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264201003226 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264201003227 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264201003228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264201003229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264201003230 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264201003231 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264201003232 active site 264201003233 homodimer interface [polypeptide binding]; other site 264201003234 cell division protein FtsW; Region: ftsW; TIGR02614 264201003235 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264201003236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264201003237 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 264201003238 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 264201003239 NAD binding site [chemical binding]; other site 264201003240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264201003241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264201003242 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264201003243 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264201003244 Mg++ binding site [ion binding]; other site 264201003245 putative catalytic motif [active] 264201003246 putative substrate binding site [chemical binding]; other site 264201003247 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 264201003248 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264201003249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264201003250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264201003251 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 264201003252 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264201003253 Di-iron ligands [ion binding]; other site 264201003254 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 264201003255 Predicted methyltransferases [General function prediction only]; Region: COG0313 264201003256 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 264201003257 putative SAM binding site [chemical binding]; other site 264201003258 putative homodimer interface [polypeptide binding]; other site 264201003259 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264201003260 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264201003261 ring oligomerisation interface [polypeptide binding]; other site 264201003262 ATP/Mg binding site [chemical binding]; other site 264201003263 stacking interactions; other site 264201003264 hinge regions; other site 264201003265 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 264201003266 Na2 binding site [ion binding]; other site 264201003267 putative substrate binding site 1 [chemical binding]; other site 264201003268 Na binding site 1 [ion binding]; other site 264201003269 putative substrate binding site 2 [chemical binding]; other site 264201003270 Flagellin N-methylase; Region: FliB; pfam03692 264201003271 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 264201003272 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 264201003273 active site 264201003274 substrate binding site [chemical binding]; other site 264201003275 metal binding site [ion binding]; metal-binding site 264201003276 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003277 pseudaminic acid synthase; Region: PseI; TIGR03586 264201003278 NeuB family; Region: NeuB; pfam03102 264201003279 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 264201003280 NeuB binding interface [polypeptide binding]; other site 264201003281 putative substrate binding site [chemical binding]; other site 264201003282 helicase 45; Provisional; Region: PTZ00424 264201003283 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264201003284 ATP binding site [chemical binding]; other site 264201003285 Mg++ binding site [ion binding]; other site 264201003286 motif III; other site 264201003287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201003288 nucleotide binding region [chemical binding]; other site 264201003289 ATP-binding site [chemical binding]; other site 264201003290 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264201003291 classical (c) SDRs; Region: SDR_c; cd05233 264201003292 NAD(P) binding site [chemical binding]; other site 264201003293 active site 264201003294 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 264201003295 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 264201003296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264201003297 Zn2+ binding site [ion binding]; other site 264201003298 Mg2+ binding site [ion binding]; other site 264201003299 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 264201003300 active site 264201003301 LexA repressor; Validated; Region: PRK00215 264201003302 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 264201003303 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264201003304 Catalytic site [active] 264201003305 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264201003306 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 264201003307 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 264201003308 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264201003309 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264201003310 Peptidase M16C associated; Region: M16C_assoc; pfam08367 264201003311 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264201003312 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003313 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003314 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003315 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201003316 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201003317 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 264201003318 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003319 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003320 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003322 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003323 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003324 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003325 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003326 DDE superfamily endonuclease; Region: DDE_3; pfam13358 264201003327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 264201003328 Transposase; Region: HTH_Tnp_IS630; pfam01710 264201003329 Helix-turn-helix domain; Region: HTH_28; pfam13518 264201003330 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003331 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003332 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003333 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 264201003334 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 264201003335 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264201003336 active site 264201003337 hypothetical protein; Provisional; Region: PRK08201 264201003338 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 264201003339 metal binding site [ion binding]; metal-binding site 264201003340 putative dimer interface [polypeptide binding]; other site 264201003341 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264201003342 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264201003343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264201003344 protein binding site [polypeptide binding]; other site 264201003345 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264201003346 protein binding site [polypeptide binding]; other site 264201003347 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264201003348 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 264201003349 nucleophile elbow; other site 264201003350 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 264201003351 Peptidase family M50; Region: Peptidase_M50; pfam02163 264201003352 active site 264201003353 putative substrate binding region [chemical binding]; other site 264201003354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264201003355 binding surface 264201003356 TPR motif; other site 264201003357 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 264201003358 CoA binding domain; Region: CoA_binding; smart00881 264201003359 CoA-ligase; Region: Ligase_CoA; pfam00549 264201003360 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 264201003361 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 264201003362 CoA-ligase; Region: Ligase_CoA; pfam00549 264201003363 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264201003364 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 264201003365 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264201003366 P loop; other site 264201003367 GTP binding site [chemical binding]; other site 264201003368 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 264201003369 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264201003370 NAD binding site [chemical binding]; other site 264201003371 homodimer interface [polypeptide binding]; other site 264201003372 active site 264201003373 substrate binding site [chemical binding]; other site 264201003374 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 264201003375 aromatic amino acid transport protein; Region: araaP; TIGR00837 264201003376 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264201003377 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264201003378 glutaminase active site [active] 264201003379 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264201003380 dimer interface [polypeptide binding]; other site 264201003381 active site 264201003382 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264201003383 dimer interface [polypeptide binding]; other site 264201003384 active site 264201003385 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 264201003386 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264201003387 active site 264201003388 substrate binding site [chemical binding]; other site 264201003389 metal binding site [ion binding]; metal-binding site 264201003390 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264201003391 active site 264201003392 NTP binding site [chemical binding]; other site 264201003393 metal binding triad [ion binding]; metal-binding site 264201003394 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264201003395 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 264201003396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264201003397 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264201003398 Putative Catalytic site; other site 264201003399 DXD motif; other site 264201003400 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 264201003401 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 264201003402 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 264201003403 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 264201003404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 264201003405 putative acyl-acceptor binding pocket; other site 264201003406 putative phosphate acyltransferase; Provisional; Region: PRK05331 264201003407 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 264201003408 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 264201003409 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264201003410 homodimer interface [polypeptide binding]; other site 264201003411 oligonucleotide binding site [chemical binding]; other site 264201003412 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 264201003413 putative acyl-acceptor binding pocket; other site 264201003414 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 264201003415 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 264201003416 Integral membrane protein TerC family; Region: TerC; cl10468 264201003417 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003418 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003419 prolyl-tRNA synthetase; Provisional; Region: PRK08661 264201003420 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 264201003421 dimer interface [polypeptide binding]; other site 264201003422 motif 1; other site 264201003423 active site 264201003424 motif 2; other site 264201003425 motif 3; other site 264201003426 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 264201003427 anticodon binding site; other site 264201003428 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 264201003429 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 264201003430 homodimer interface [polypeptide binding]; other site 264201003431 substrate-cofactor binding pocket; other site 264201003432 Aminotransferase class IV; Region: Aminotran_4; pfam01063 264201003433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201003434 catalytic residue [active] 264201003435 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 264201003436 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264201003437 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 264201003438 hypothetical protein; Validated; Region: PRK00110 264201003439 SprT-like family; Region: SprT-like; pfam10263 264201003440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264201003441 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 264201003442 Coenzyme A binding pocket [chemical binding]; other site 264201003443 peptide chain release factor 2; Provisional; Region: PRK05589 264201003444 This domain is found in peptide chain release factors; Region: PCRF; smart00937 264201003445 RF-1 domain; Region: RF-1; pfam00472 264201003446 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264201003447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264201003448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 264201003449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201003450 Walker A/P-loop; other site 264201003451 ATP binding site [chemical binding]; other site 264201003452 Q-loop/lid; other site 264201003453 ABC transporter signature motif; other site 264201003454 Walker B; other site 264201003455 D-loop; other site 264201003456 H-loop/switch region; other site 264201003457 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264201003458 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 264201003459 Thioredoxin; Region: Thioredoxin_4; pfam13462 264201003460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 264201003461 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 264201003462 Predicted flavoprotein [General function prediction only]; Region: COG0431 264201003463 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 264201003464 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 264201003465 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264201003466 metal binding triad [ion binding]; metal-binding site 264201003467 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201003468 Leucine-rich repeats; other site 264201003469 Substrate binding site [chemical binding]; other site 264201003470 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 264201003471 Leucine-rich repeats; other site 264201003472 Substrate binding site [chemical binding]; other site 264201003473 Leucine rich repeat; Region: LRR_8; pfam13855 264201003474 TLC ATP/ADP transporter; Region: TLC; pfam03219 264201003475 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 264201003476 putative ArsC-like catalytic residues; other site 264201003477 putative TRX-like catalytic residues [active] 264201003478 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 264201003479 Tetratricopeptide repeat; Region: TPR_2; pfam07719 264201003480 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 264201003481 active site 264201003482 conformational flexibility of ligand binding pocket; other site 264201003483 ADP-ribosylating toxin turn-turn motif; other site 264201003484 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 264201003485 ATP cone domain; Region: ATP-cone; pfam03477 264201003486 Class I ribonucleotide reductase; Region: RNR_I; cd01679 264201003487 active site 264201003488 dimer interface [polypeptide binding]; other site 264201003489 catalytic residues [active] 264201003490 effector binding site; other site 264201003491 R2 peptide binding site; other site 264201003492 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 264201003493 dimer interface [polypeptide binding]; other site 264201003494 putative radical transfer pathway; other site 264201003495 diiron center [ion binding]; other site 264201003496 tyrosyl radical; other site 264201003497 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 264201003498 F-box-like; Region: F-box-like; pfam12937 264201003499 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 264201003500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264201003501 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 264201003502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264201003503 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 264201003504 propionate/acetate kinase; Provisional; Region: PRK12379 264201003505 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 264201003506 RasGEF domain; Region: RasGEF; pfam00617 264201003507 Ras interaction site [polypeptide binding]; other site 264201003508 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264201003509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264201003510 active site 264201003511 phosphorylation site [posttranslational modification] 264201003512 intermolecular recognition site; other site 264201003513 dimerization interface [polypeptide binding]; other site 264201003514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201003515 Walker A motif; other site 264201003516 ATP binding site [chemical binding]; other site 264201003517 Walker B motif; other site 264201003518 arginine finger; other site 264201003519 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 264201003520 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264201003521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264201003522 dimer interface [polypeptide binding]; other site 264201003523 phosphorylation site [posttranslational modification] 264201003524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264201003525 ATP binding site [chemical binding]; other site 264201003526 Mg2+ binding site [ion binding]; other site 264201003527 G-X-G motif; other site 264201003528 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264201003529 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264201003530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264201003531 RNA binding surface [nucleotide binding]; other site 264201003532 Haemolytic domain; Region: Haemolytic; pfam01809 264201003533 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264201003534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201003535 active site 264201003536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201003537 binding surface 264201003538 TPR motif; other site 264201003539 TPR repeat; Region: TPR_11; pfam13414 264201003540 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264201003541 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264201003542 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 264201003543 active site 264201003544 substrate-binding site [chemical binding]; other site 264201003545 metal-binding site [ion binding] 264201003546 GTP binding site [chemical binding]; other site 264201003547 rod shape-determining protein MreB; Provisional; Region: PRK13927 264201003548 MreB and similar proteins; Region: MreB_like; cd10225 264201003549 nucleotide binding site [chemical binding]; other site 264201003550 Mg binding site [ion binding]; other site 264201003551 putative protofilament interaction site [polypeptide binding]; other site 264201003552 RodZ interaction site [polypeptide binding]; other site 264201003553 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 264201003554 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 264201003555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201003556 ATP binding site [chemical binding]; other site 264201003557 putative Mg++ binding site [ion binding]; other site 264201003558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201003559 nucleotide binding region [chemical binding]; other site 264201003560 ATP-binding site [chemical binding]; other site 264201003561 trigger factor; Region: tig; TIGR00115 264201003562 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264201003563 Clp protease; Region: CLP_protease; pfam00574 264201003564 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264201003565 oligomer interface [polypeptide binding]; other site 264201003566 active site residues [active] 264201003567 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264201003568 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 264201003569 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 264201003570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201003571 Walker A motif; other site 264201003572 ATP binding site [chemical binding]; other site 264201003573 Walker B motif; other site 264201003574 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 264201003575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264201003576 Coenzyme A binding pocket [chemical binding]; other site 264201003577 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 264201003578 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 264201003579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201003580 binding surface 264201003581 TPR motif; other site 264201003582 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 264201003583 TRADD, N-terminal domain; Region: TRADD_N; pfam09034 264201003584 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 264201003585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264201003586 binding surface 264201003587 TPR motif; other site 264201003588 Tir chaperone protein (CesT) family; Region: CesT; cl08444 264201003589 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264201003590 phosphopeptide binding site; other site 264201003591 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264201003592 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 264201003593 phosphopeptide binding site; other site 264201003594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201003595 active site 264201003596 type III secretion system ATPase; Provisional; Region: PRK06315 264201003597 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264201003598 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 264201003599 Walker A motif/ATP binding site; other site 264201003600 Walker B motif; other site 264201003601 phosphodiesterase; Provisional; Region: PRK12704 264201003602 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 264201003603 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 264201003604 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264201003605 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264201003606 active site 264201003607 ATP binding site [chemical binding]; other site 264201003608 substrate binding site [chemical binding]; other site 264201003609 activation loop (A-loop); other site 264201003610 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 264201003611 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 264201003612 Helix-turn-helix domain; Region: HTH_17; pfam12728 264201003613 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264201003614 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 264201003615 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264201003616 Helix-turn-helix domain; Region: HTH_17; pfam12728 264201003617 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 264201003618 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 264201003619 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264201003620 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003621 TraL protein; Region: TraL; cl06278 264201003622 type IV conjugative transfer system protein TraE; Region: TraE_TIGR; TIGR02761 264201003623 TraK protein; Region: TraK; pfam06586 264201003624 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 264201003625 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 264201003626 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003627 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 264201003628 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 264201003629 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 264201003630 Walker A motif; other site 264201003631 ATP binding site [chemical binding]; other site 264201003632 Walker B motif; other site 264201003633 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 264201003634 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 264201003635 type-F conjugative transfer system protein TraW; Region: TraW; TIGR02743 264201003636 type-F conjugative transfer system pilin assembly protein TrbC; Region: TrbC_Ftype; TIGR02742 264201003637 TraU protein; Region: TraU; pfam06834 264201003638 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 264201003639 type-F conjugative transfer system pilin assembly protein TraF; Region: TraF; TIGR02739 264201003640 F plasmid transfer operon protein; Region: TraF; pfam13728 264201003641 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 264201003642 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 264201003643 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 264201003644 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 264201003645 multimer interface [polypeptide binding]; other site 264201003646 Walker A motif; other site 264201003647 ATP binding site [chemical binding]; other site 264201003648 Walker B motif; other site 264201003649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264201003650 non-specific DNA binding site [nucleotide binding]; other site 264201003651 salt bridge; other site 264201003652 sequence-specific DNA binding site [nucleotide binding]; other site 264201003653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264201003654 non-specific DNA binding site [nucleotide binding]; other site 264201003655 salt bridge; other site 264201003656 sequence-specific DNA binding site [nucleotide binding]; other site 264201003657 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 264201003658 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264201003659 A Receptor for Ubiquitination Targets; Region: FBOX; smart00256 264201003660 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201003661 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 264201003662 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201003663 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201003664 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201003665 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201003666 RmuC family; Region: RmuC; pfam02646 264201003667 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 264201003668 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 264201003669 HicB family; Region: HicB; pfam05534 264201003670 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201003671 Leucine-rich repeats; other site 264201003672 Substrate binding site [chemical binding]; other site 264201003673 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 264201003674 Leucine-rich repeats; other site 264201003675 Substrate binding site [chemical binding]; other site 264201003676 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003677 Leucine rich repeat; Region: LRR_8; pfam13855 264201003678 Fic/DOC family; Region: Fic; cl00960 264201003679 Methyltransferase domain; Region: Methyltransf_32; pfam13679 264201003680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264201003681 non-specific DNA binding site [nucleotide binding]; other site 264201003682 salt bridge; other site 264201003683 sequence-specific DNA binding site [nucleotide binding]; other site 264201003684 BTB/POZ domain; Region: BTB; cl02518 264201003685 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003686 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003687 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003688 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264201003689 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264201003690 multiple promoter invertase; Provisional; Region: mpi; PRK13413 264201003691 catalytic residues [active] 264201003692 catalytic nucleophile [active] 264201003693 Presynaptic Site I dimer interface [polypeptide binding]; other site 264201003694 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 264201003695 Synaptic Flat tetramer interface [polypeptide binding]; other site 264201003696 Synaptic Site I dimer interface [polypeptide binding]; other site 264201003697 DNA binding site [nucleotide binding] 264201003698 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264201003699 DNA-binding interface [nucleotide binding]; DNA binding site 264201003700 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264201003701 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264201003702 Fic/DOC family; Region: Fic; cl00960 264201003703 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 264201003704 type II secretion system protein D; Region: type_II_gspD; TIGR02517 264201003705 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264201003706 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264201003707 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 264201003708 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264201003709 Haemolytic domain; Region: Haemolytic; cl00506 264201003710 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264201003711 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 264201003712 Sulfate transporter family; Region: Sulfate_transp; pfam00916 264201003713 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264201003714 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 264201003715 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264201003716 G1 box; other site 264201003717 GTP/Mg2+ binding site [chemical binding]; other site 264201003718 Switch I region; other site 264201003719 G2 box; other site 264201003720 Switch II region; other site 264201003721 G3 box; other site 264201003722 G4 box; other site 264201003723 G5 box; other site 264201003724 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264201003725 G1 box; other site 264201003726 GTP/Mg2+ binding site [chemical binding]; other site 264201003727 Switch I region; other site 264201003728 G2 box; other site 264201003729 G3 box; other site 264201003730 Switch II region; other site 264201003731 G4 box; other site 264201003732 G5 box; other site 264201003733 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264201003734 active site 264201003735 catalytic residues [active] 264201003736 Domain of unknown function DUF21; Region: DUF21; pfam01595 264201003737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264201003738 FOG: CBS domain [General function prediction only]; Region: COG0517 264201003739 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 264201003740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201003741 ATP binding site [chemical binding]; other site 264201003742 putative Mg++ binding site [ion binding]; other site 264201003743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201003744 nucleotide binding region [chemical binding]; other site 264201003745 ATP-binding site [chemical binding]; other site 264201003746 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 264201003747 nucleotide binding site [chemical binding]; other site 264201003748 putative NEF/HSP70 interaction site [polypeptide binding]; other site 264201003749 SBD interface [polypeptide binding]; other site 264201003750 DNA-K related protein; Region: DUF3731; pfam12531 264201003751 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264201003752 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 264201003753 hexamer interface [polypeptide binding]; other site 264201003754 ligand binding site [chemical binding]; other site 264201003755 putative active site [active] 264201003756 NAD(P) binding site [chemical binding]; other site 264201003757 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201003758 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264201003759 Walker A/P-loop; other site 264201003760 ATP binding site [chemical binding]; other site 264201003761 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 264201003762 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 264201003763 ABC transporter signature motif; other site 264201003764 Walker B; other site 264201003765 D-loop; other site 264201003766 H-loop/switch region; other site 264201003767 seryl-tRNA synthetase; Provisional; Region: PRK05431 264201003768 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264201003769 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 264201003770 dimer interface [polypeptide binding]; other site 264201003771 active site 264201003772 motif 1; other site 264201003773 motif 2; other site 264201003774 motif 3; other site 264201003775 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 264201003776 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 264201003777 active site 264201003778 metal binding site [ion binding]; metal-binding site 264201003779 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201003780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264201003781 BTB/POZ domain; Region: BTB; cl02518 264201003782 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003783 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003784 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 264201003785 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 264201003786 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 264201003787 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 264201003788 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264201003789 dimer interface [polypeptide binding]; other site 264201003790 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264201003791 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264201003792 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 264201003793 nucleotide binding site [chemical binding]; other site 264201003794 NEF interaction site [polypeptide binding]; other site 264201003795 SBD interface [polypeptide binding]; other site 264201003796 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 264201003797 Bacterial SH3 domain; Region: SH3_4; pfam06347 264201003798 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264201003799 NlpC/P60 family; Region: NLPC_P60; pfam00877 264201003800 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264201003801 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 264201003802 peptide binding site [polypeptide binding]; other site 264201003803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264201003804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201003805 dimer interface [polypeptide binding]; other site 264201003806 conserved gate region; other site 264201003807 putative PBP binding loops; other site 264201003808 ABC-ATPase subunit interface; other site 264201003809 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264201003810 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264201003811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264201003812 dimer interface [polypeptide binding]; other site 264201003813 conserved gate region; other site 264201003814 putative PBP binding loops; other site 264201003815 ABC-ATPase subunit interface; other site 264201003816 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264201003817 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264201003818 Walker A/P-loop; other site 264201003819 ATP binding site [chemical binding]; other site 264201003820 Q-loop/lid; other site 264201003821 ABC transporter signature motif; other site 264201003822 Walker B; other site 264201003823 D-loop; other site 264201003824 H-loop/switch region; other site 264201003825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264201003826 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 264201003827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 264201003828 Walker A/P-loop; other site 264201003829 ATP binding site [chemical binding]; other site 264201003830 Q-loop/lid; other site 264201003831 ABC transporter signature motif; other site 264201003832 Walker B; other site 264201003833 D-loop; other site 264201003834 H-loop/switch region; other site 264201003835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264201003836 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003837 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003838 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003839 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003840 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003841 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003842 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003843 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003844 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003845 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 264201003846 Clp amino terminal domain; Region: Clp_N; pfam02861 264201003847 Clp amino terminal domain; Region: Clp_N; pfam02861 264201003848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201003849 Walker A motif; other site 264201003850 ATP binding site [chemical binding]; other site 264201003851 Walker B motif; other site 264201003852 arginine finger; other site 264201003853 UvrB/uvrC motif; Region: UVR; pfam02151 264201003854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201003855 Walker A motif; other site 264201003856 ATP binding site [chemical binding]; other site 264201003857 Walker B motif; other site 264201003858 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 264201003859 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 264201003860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 264201003861 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 264201003862 substrate binding site [chemical binding]; other site 264201003863 active site 264201003864 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 264201003865 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264201003866 TPP-binding site [chemical binding]; other site 264201003867 dimer interface [polypeptide binding]; other site 264201003868 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264201003869 PYR/PP interface [polypeptide binding]; other site 264201003870 dimer interface [polypeptide binding]; other site 264201003871 TPP binding site [chemical binding]; other site 264201003872 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264201003873 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264201003874 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 264201003875 motif 1; other site 264201003876 active site 264201003877 motif 2; other site 264201003878 motif 3; other site 264201003879 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264201003880 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 264201003881 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264201003882 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 264201003883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264201003884 ATP binding site [chemical binding]; other site 264201003885 putative Mg++ binding site [ion binding]; other site 264201003886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201003887 nucleotide binding region [chemical binding]; other site 264201003888 ATP-binding site [chemical binding]; other site 264201003889 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 264201003890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264201003891 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264201003892 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 264201003893 AMP nucleosidase; Provisional; Region: PRK07115 264201003894 translation elongation factor P; Region: efp; TIGR00038 264201003895 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264201003896 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264201003897 RNA binding site [nucleotide binding]; other site 264201003898 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264201003899 RNA binding site [nucleotide binding]; other site 264201003900 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 264201003901 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 264201003902 motif 1; other site 264201003903 dimer interface [polypeptide binding]; other site 264201003904 active site 264201003905 motif 2; other site 264201003906 motif 3; other site 264201003907 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 264201003908 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 264201003909 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264201003910 catalytic loop [active] 264201003911 iron binding site [ion binding]; other site 264201003912 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 264201003913 FAD binding pocket [chemical binding]; other site 264201003914 FAD binding motif [chemical binding]; other site 264201003915 phosphate binding motif [ion binding]; other site 264201003916 beta-alpha-beta structure motif; other site 264201003917 NAD binding pocket [chemical binding]; other site 264201003918 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264201003919 homotrimer interaction site [polypeptide binding]; other site 264201003920 putative active site [active] 264201003921 heat shock protein 90; Provisional; Region: PRK05218 264201003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264201003923 ATP binding site [chemical binding]; other site 264201003924 Mg2+ binding site [ion binding]; other site 264201003925 G-X-G motif; other site 264201003926 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 264201003927 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264201003928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264201003929 active site 264201003930 metal binding site [ion binding]; metal-binding site 264201003931 Autophagy protein Apg17; Region: APG17; pfam04108 264201003932 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 264201003933 Archaeal ADP-dependent phosphofructokinase/glucokinase [Carbohydrate transport and metabolism]; Region: COG4809 264201003934 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 264201003935 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264201003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201003937 S-adenosylmethionine binding site [chemical binding]; other site 264201003938 Histone H1-like protein Hc1; Region: Hc1; pfam07432 264201003939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201003940 binding surface 264201003941 TPR motif; other site 264201003942 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264201003943 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264201003944 FkbH-like domain; Region: FkbH; TIGR01686 264201003945 Fasciclin domain; Region: Fasciclin; pfam02469 264201003946 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 264201003947 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264201003948 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264201003949 active site 264201003950 catalytic site [active] 264201003951 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 264201003952 ferrochelatase; Reviewed; Region: hemH; PRK00035 264201003953 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 264201003954 C-terminal domain interface [polypeptide binding]; other site 264201003955 active site 264201003956 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 264201003957 active site 264201003958 N-terminal domain interface [polypeptide binding]; other site 264201003959 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 264201003960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201003961 Walker A motif; other site 264201003962 ATP binding site [chemical binding]; other site 264201003963 Walker B motif; other site 264201003964 arginine finger; other site 264201003965 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 264201003966 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264201003967 ATP binding site [chemical binding]; other site 264201003968 Mg++ binding site [ion binding]; other site 264201003969 motif III; other site 264201003970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264201003971 nucleotide binding region [chemical binding]; other site 264201003972 ATP-binding site [chemical binding]; other site 264201003973 Transposase; Region: HTH_Tnp_IS630; pfam01710 264201003974 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003975 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003976 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003977 BTB/POZ domain; Region: BTB; cl02518 264201003978 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003979 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003980 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003981 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201003982 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003983 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201003984 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 264201003985 ligand binding site; other site 264201003986 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 264201003987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264201003988 motif II; other site 264201003989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264201003990 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264201003991 NAD(P) binding site [chemical binding]; other site 264201003992 active site 264201003993 ATP-grasp domain; Region: ATP-grasp_4; cl17255 264201003994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 264201003995 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264201003996 CoA binding domain; Region: CoA_binding_2; pfam13380 264201003997 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 264201003998 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 264201003999 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264201004000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 264201004001 RNB domain; Region: RNB; pfam00773 264201004002 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 264201004003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264201004004 RNA binding site [nucleotide binding]; other site 264201004005 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264201004006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201004007 ABC transporter; Region: ABC_tran_2; pfam12848 264201004008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 264201004009 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264201004010 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 264201004011 G1 box; other site 264201004012 putative GEF interaction site [polypeptide binding]; other site 264201004013 GTP/Mg2+ binding site [chemical binding]; other site 264201004014 Switch I region; other site 264201004015 G2 box; other site 264201004016 G3 box; other site 264201004017 Switch II region; other site 264201004018 G4 box; other site 264201004019 G5 box; other site 264201004020 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264201004021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201004022 S-adenosylmethionine binding site [chemical binding]; other site 264201004023 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 264201004024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 264201004025 active site 264201004026 dimerization interface [polypeptide binding]; other site 264201004027 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264201004028 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 264201004029 putative NAD(P) binding site [chemical binding]; other site 264201004030 homodimer interface [polypeptide binding]; other site 264201004031 homotetramer interface [polypeptide binding]; other site 264201004032 active site 264201004033 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264201004034 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264201004035 FMN binding site [chemical binding]; other site 264201004036 active site 264201004037 catalytic residues [active] 264201004038 substrate binding site [chemical binding]; other site 264201004039 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264201004040 nudix motif; other site 264201004041 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264201004042 metal binding site [ion binding]; metal-binding site 264201004043 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264201004044 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 264201004045 putative ribose interaction site [chemical binding]; other site 264201004046 putative ADP binding site [chemical binding]; other site 264201004047 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 264201004048 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 264201004049 NADP binding site [chemical binding]; other site 264201004050 homopentamer interface [polypeptide binding]; other site 264201004051 substrate binding site [chemical binding]; other site 264201004052 active site 264201004053 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 264201004054 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264201004055 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264201004056 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264201004057 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264201004058 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 264201004059 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 264201004060 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264201004061 putative active site [active] 264201004062 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264201004063 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 264201004064 5S rRNA interface [nucleotide binding]; other site 264201004065 CTC domain interface [polypeptide binding]; other site 264201004066 L16 interface [polypeptide binding]; other site 264201004067 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264201004068 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264201004069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264201004070 active site 264201004071 glycogen synthase; Provisional; Region: glgA; PRK00654 264201004072 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 264201004073 ADP-binding pocket [chemical binding]; other site 264201004074 homodimer interface [polypeptide binding]; other site 264201004075 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 264201004076 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264201004077 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 264201004078 Domain of unknown function (DUF367); Region: DUF367; pfam04034 264201004079 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 264201004080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264201004081 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264201004082 Part of AAA domain; Region: AAA_19; pfam13245 264201004083 Family description; Region: UvrD_C_2; pfam13538 264201004084 Ribonuclease P; Region: Ribonuclease_P; pfam00825 264201004085 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 264201004086 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 264201004087 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 264201004088 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 264201004089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 264201004090 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264201004091 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201004092 Leucine-rich repeats; other site 264201004093 Substrate binding site [chemical binding]; other site 264201004094 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201004095 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201004096 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201004097 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201004098 BTB/POZ domain; Region: BTB; cl02518 264201004099 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004100 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004101 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004102 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 264201004103 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 264201004104 active site 264201004105 catalytic site [active] 264201004106 substrate binding site [chemical binding]; other site 264201004107 transcription antitermination factor NusB; Region: nusB; TIGR01951 264201004108 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 264201004109 FAD binding domain; Region: FAD_binding_4; pfam01565 264201004110 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264201004111 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 264201004112 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264201004113 active site 264201004114 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 264201004115 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 264201004116 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264201004117 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264201004118 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264201004119 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264201004120 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264201004121 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 264201004122 dihydropteroate synthase; Region: DHPS; TIGR01496 264201004123 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264201004124 substrate binding pocket [chemical binding]; other site 264201004125 dimer interface [polypeptide binding]; other site 264201004126 inhibitor binding site; inhibition site 264201004127 Uncharacterized conserved protein [Function unknown]; Region: COG1624 264201004128 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 264201004129 RNA methyltransferase, RsmE family; Region: TIGR00046 264201004130 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 264201004131 pyruvate kinase; Provisional; Region: PRK06354 264201004132 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 264201004133 domain interfaces; other site 264201004134 active site 264201004135 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 264201004136 DDE superfamily endonuclease; Region: DDE_3; pfam13358 264201004137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 264201004138 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201004139 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201004140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201004141 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201004142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264201004143 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 264201004144 active site 264201004145 nucleophile elbow; other site 264201004146 NB-ARC domain; Region: NB-ARC; pfam00931 264201004147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201004148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264201004149 binding surface 264201004150 TPR motif; other site 264201004151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201004152 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201004153 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264201004154 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264201004155 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264201004156 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264201004157 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264201004158 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264201004159 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 264201004160 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 264201004161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201004162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264201004163 putative substrate translocation pore; other site 264201004164 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 264201004165 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264201004166 active site 264201004167 ATP binding site [chemical binding]; other site 264201004168 substrate binding site [chemical binding]; other site 264201004169 activation loop (A-loop); other site 264201004170 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264201004171 dimer interface [polypeptide binding]; other site 264201004172 ADP-ribose binding site [chemical binding]; other site 264201004173 active site 264201004174 nudix motif; other site 264201004175 metal binding site [ion binding]; metal-binding site 264201004176 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201004177 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004178 HTH-like domain; Region: HTH_21; pfam13276 264201004179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 264201004180 Integrase core domain; Region: rve_3; pfam13683 264201004181 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cl17238 264201004182 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201004183 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264201004184 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264201004185 active site 264201004186 HIGH motif; other site 264201004187 nucleotide binding site [chemical binding]; other site 264201004188 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264201004189 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264201004190 active site 264201004191 KMSKS motif; other site 264201004192 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264201004193 tRNA binding surface [nucleotide binding]; other site 264201004194 anticodon binding site; other site 264201004195 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264201004196 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 264201004197 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264201004198 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 264201004199 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 264201004200 amino acid carrier protein; Region: agcS; TIGR00835 264201004201 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 264201004202 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264201004203 fumarate hydratase; Reviewed; Region: fumC; PRK00485 264201004204 Class II fumarases; Region: Fumarase_classII; cd01362 264201004205 active site 264201004206 tetramer interface [polypeptide binding]; other site 264201004207 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 264201004208 Sel1-like repeats; Region: SEL1; smart00671 264201004209 Sel1 repeat; Region: Sel1; cl02723 264201004210 Sel1-like repeats; Region: SEL1; smart00671 264201004211 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 264201004212 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 264201004213 active site 264201004214 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201004215 Flavodoxin domain; Region: Flavodoxin_5; cl17428 264201004216 BTB/POZ domain; Region: BTB; cl02518 264201004217 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004218 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004219 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 264201004220 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 264201004221 gamma subunit interface [polypeptide binding]; other site 264201004222 epsilon subunit interface [polypeptide binding]; other site 264201004223 LBP interface [polypeptide binding]; other site 264201004224 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264201004225 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264201004226 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264201004227 alpha subunit interaction interface [polypeptide binding]; other site 264201004228 Walker A motif; other site 264201004229 ATP binding site [chemical binding]; other site 264201004230 Walker B motif; other site 264201004231 inhibitor binding site; inhibition site 264201004232 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264201004233 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 264201004234 core domain interface [polypeptide binding]; other site 264201004235 delta subunit interface [polypeptide binding]; other site 264201004236 epsilon subunit interface [polypeptide binding]; other site 264201004237 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264201004238 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264201004239 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264201004240 beta subunit interaction interface [polypeptide binding]; other site 264201004241 Walker A motif; other site 264201004242 ATP binding site [chemical binding]; other site 264201004243 Walker B motif; other site 264201004244 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264201004245 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 264201004246 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264201004247 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264201004248 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 264201004249 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 264201004250 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 264201004251 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 264201004252 V-type ATP synthase subunit K; Provisional; Region: PRK09621 264201004253 V-type ATP synthase subunit I; Validated; Region: PRK05771 264201004254 V-type ATP synthase subunit D; Provisional; Region: PRK02195 264201004255 V-type ATP synthase subunit B; Provisional; Region: PRK02118 264201004256 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264201004257 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 264201004258 Walker A motif homologous position; other site 264201004259 Walker B motif; other site 264201004260 V-type ATP synthase subunit A; Provisional; Region: PRK04192 264201004261 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 264201004262 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 264201004263 Walker A motif/ATP binding site; other site 264201004264 Walker B motif; other site 264201004265 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264201004266 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 264201004267 V-type ATP synthase subunit E; Provisional; Region: PRK01005 264201004268 V-type ATP synthase subunit E; Provisional; Region: PRK01558 264201004269 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 264201004270 transaldolase-like protein; Provisional; Region: PTZ00411 264201004271 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 264201004272 active site 264201004273 dimer interface [polypeptide binding]; other site 264201004274 catalytic residue [active] 264201004275 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 264201004276 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 264201004277 NAD binding site [chemical binding]; other site 264201004278 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264201004279 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 264201004280 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264201004281 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264201004282 substrate binding pocket [chemical binding]; other site 264201004283 chain length determination region; other site 264201004284 substrate-Mg2+ binding site; other site 264201004285 catalytic residues [active] 264201004286 aspartate-rich region 1; other site 264201004287 active site lid residues [active] 264201004288 aspartate-rich region 2; other site 264201004289 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 264201004290 Bacterial sugar transferase; Region: Bac_transf; pfam02397 264201004291 recombination factor protein RarA; Reviewed; Region: PRK13342 264201004292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201004293 Walker A motif; other site 264201004294 ATP binding site [chemical binding]; other site 264201004295 Walker B motif; other site 264201004296 arginine finger; other site 264201004297 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264201004298 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 264201004299 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264201004300 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264201004301 homodimer interface [polypeptide binding]; other site 264201004302 NADP binding site [chemical binding]; other site 264201004303 substrate binding site [chemical binding]; other site 264201004304 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 264201004305 ApbE family; Region: ApbE; pfam02424 264201004306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 264201004307 putative Zn2+ binding site [ion binding]; other site 264201004308 DNA polymerase III subunit beta; Validated; Region: PRK05643 264201004309 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264201004310 putative DNA binding surface [nucleotide binding]; other site 264201004311 dimer interface [polypeptide binding]; other site 264201004312 beta-clamp/clamp loader binding surface; other site 264201004313 beta-clamp/translesion DNA polymerase binding surface; other site 264201004314 recombination protein F; Reviewed; Region: recF; PRK00064 264201004315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201004316 Walker A/P-loop; other site 264201004317 ATP binding site [chemical binding]; other site 264201004318 Q-loop/lid; other site 264201004319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201004320 ABC transporter signature motif; other site 264201004321 Walker B; other site 264201004322 D-loop; other site 264201004323 H-loop/switch region; other site 264201004324 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264201004325 SmpB-tmRNA interface; other site 264201004326 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 264201004327 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 264201004328 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264201004329 putative active site [active] 264201004330 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 264201004331 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 264201004332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264201004333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264201004334 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264201004335 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 264201004336 Na binding site [ion binding]; other site 264201004337 acyl carrier protein; Provisional; Region: acpP; PRK00982 264201004338 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264201004339 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264201004340 NAD(P) binding site [chemical binding]; other site 264201004341 homotetramer interface [polypeptide binding]; other site 264201004342 homodimer interface [polypeptide binding]; other site 264201004343 active site 264201004344 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 264201004345 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264201004346 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264201004347 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264201004348 dimer interface [polypeptide binding]; other site 264201004349 active site 264201004350 CoA binding pocket [chemical binding]; other site 264201004351 PT repeat; Region: PT; pfam04886 264201004352 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 264201004353 recombination protein RecR; Reviewed; Region: recR; PRK00076 264201004354 RecR protein; Region: RecR; pfam02132 264201004355 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264201004356 putative active site [active] 264201004357 putative metal-binding site [ion binding]; other site 264201004358 tetramer interface [polypeptide binding]; other site 264201004359 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 264201004360 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264201004361 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264201004362 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264201004363 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264201004364 Surface antigen; Region: Bac_surface_Ag; pfam01103 264201004365 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 264201004366 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 264201004367 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 264201004368 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 264201004369 trimer interface [polypeptide binding]; other site 264201004370 active site 264201004371 UDP-GlcNAc binding site [chemical binding]; other site 264201004372 lipid binding site [chemical binding]; lipid-binding site 264201004373 Protein phosphatase 2C; Region: PP2C; pfam00481 264201004374 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264201004375 active site 264201004376 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 264201004377 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264201004378 E3 interaction surface; other site 264201004379 lipoyl attachment site [posttranslational modification]; other site 264201004380 e3 binding domain; Region: E3_binding; pfam02817 264201004381 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 264201004382 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264201004383 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 264201004384 alpha subunit interface [polypeptide binding]; other site 264201004385 TPP binding site [chemical binding]; other site 264201004386 heterodimer interface [polypeptide binding]; other site 264201004387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264201004388 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 264201004389 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264201004390 tetramer interface [polypeptide binding]; other site 264201004391 TPP-binding site [chemical binding]; other site 264201004392 heterodimer interface [polypeptide binding]; other site 264201004393 phosphorylation loop region [posttranslational modification] 264201004394 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264201004395 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 264201004396 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 264201004397 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264201004398 catalytic residue [active] 264201004399 hypothetical protein; Provisional; Region: PRK13665 264201004400 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 264201004401 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 264201004402 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 264201004403 active site residues [active] 264201004404 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 264201004405 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264201004406 inhibitor-cofactor binding pocket; inhibition site 264201004407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264201004408 catalytic residue [active] 264201004409 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 264201004410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 264201004411 Surface antigen; Region: Bac_surface_Ag; pfam01103 264201004412 Family of unknown function (DUF490); Region: DUF490; pfam04357 264201004413 Family of unknown function (DUF490); Region: DUF490; pfam04357 264201004414 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 264201004415 Permease; Region: Permease; pfam02405 264201004416 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 264201004417 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 264201004418 Walker A/P-loop; other site 264201004419 ATP binding site [chemical binding]; other site 264201004420 Q-loop/lid; other site 264201004421 ABC transporter signature motif; other site 264201004422 Walker B; other site 264201004423 D-loop; other site 264201004424 H-loop/switch region; other site 264201004425 mce related protein; Region: MCE; pfam02470 264201004426 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 264201004427 hypothetical protein; Validated; Region: PRK00228 264201004428 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 264201004429 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264201004430 23S rRNA interface [nucleotide binding]; other site 264201004431 L3 interface [polypeptide binding]; other site 264201004432 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 264201004433 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264201004434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201004435 FeS/SAM binding site; other site 264201004436 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 264201004437 E-class dimer interface [polypeptide binding]; other site 264201004438 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 264201004439 P-class dimer interface [polypeptide binding]; other site 264201004440 active site 264201004441 Cu2+ binding site [ion binding]; other site 264201004442 Zn2+ binding site [ion binding]; other site 264201004443 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264201004444 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264201004445 nucleotide binding pocket [chemical binding]; other site 264201004446 K-X-D-G motif; other site 264201004447 catalytic site [active] 264201004448 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264201004449 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264201004450 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264201004451 Dimer interface [polypeptide binding]; other site 264201004452 BRCT sequence motif; other site 264201004453 glycogen branching enzyme; Provisional; Region: PRK05402 264201004454 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 264201004455 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 264201004456 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 264201004457 active site 264201004458 catalytic site [active] 264201004459 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 264201004460 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264201004461 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 264201004462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264201004463 FeS/SAM binding site; other site 264201004464 hypothetical protein; Reviewed; Region: PRK00024 264201004465 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264201004466 MPN+ (JAMM) motif; other site 264201004467 Zinc-binding site [ion binding]; other site 264201004468 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264201004469 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 264201004470 HflX GTPase family; Region: HflX; cd01878 264201004471 G1 box; other site 264201004472 GTP/Mg2+ binding site [chemical binding]; other site 264201004473 Switch I region; other site 264201004474 G2 box; other site 264201004475 G3 box; other site 264201004476 Switch II region; other site 264201004477 G4 box; other site 264201004478 G5 box; other site 264201004479 putative hydrolase; Provisional; Region: PRK02113 264201004480 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 264201004481 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264201004482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 264201004483 type I citrate synthase; Reviewed; Region: PRK09569 264201004484 Citrate synthase; Region: Citrate_synt; pfam00285 264201004485 oxalacetate binding site [chemical binding]; other site 264201004486 citrylCoA binding site [chemical binding]; other site 264201004487 coenzyme A binding site [chemical binding]; other site 264201004488 catalytic triad [active] 264201004489 malate dehydrogenase; Provisional; Region: PRK05442 264201004490 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 264201004491 NAD(P) binding site [chemical binding]; other site 264201004492 dimer interface [polypeptide binding]; other site 264201004493 malate binding site [chemical binding]; other site 264201004494 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 264201004495 Domain of unknown function (DUF2431); Region: DUF2431; pfam10354 264201004496 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 264201004497 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264201004498 KpsF/GutQ family protein; Region: kpsF; TIGR00393 264201004499 putative active site [active] 264201004500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264201004501 isocitrate dehydrogenase; Validated; Region: PRK09222 264201004502 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 264201004503 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 264201004504 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264201004505 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 264201004506 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 264201004507 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 264201004508 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 264201004509 dimer interface [polypeptide binding]; other site 264201004510 active site 264201004511 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 264201004512 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 264201004513 putative catalytic residue [active] 264201004514 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264201004515 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264201004516 active site 264201004517 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264201004518 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 264201004519 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 264201004520 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264201004521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 264201004522 nucleotide binding site [chemical binding]; other site 264201004523 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 264201004524 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 264201004525 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 264201004526 ATP cone domain; Region: ATP-cone; pfam03477 264201004527 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 264201004528 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264201004529 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264201004530 metal binding site 2 [ion binding]; metal-binding site 264201004531 putative DNA binding helix; other site 264201004532 metal binding site 1 [ion binding]; metal-binding site 264201004533 dimer interface [polypeptide binding]; other site 264201004534 structural Zn2+ binding site [ion binding]; other site 264201004535 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 264201004536 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264201004537 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264201004538 putative dimer interface [polypeptide binding]; other site 264201004539 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 264201004540 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 264201004541 putative metal binding residues [ion binding]; other site 264201004542 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 264201004543 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 264201004544 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 264201004545 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264201004546 ABC-ATPase subunit interface; other site 264201004547 dimer interface [polypeptide binding]; other site 264201004548 putative PBP binding regions; other site 264201004549 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264201004550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264201004551 replicative DNA helicase; Provisional; Region: PRK06321 264201004552 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264201004553 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264201004554 Walker A motif; other site 264201004555 ATP binding site [chemical binding]; other site 264201004556 Walker B motif; other site 264201004557 DNA binding loops [nucleotide binding] 264201004558 Fic family protein [Function unknown]; Region: COG3177 264201004559 Fic/DOC family; Region: Fic; pfam02661 264201004560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264201004561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264201004562 DNA binding residues [nucleotide binding] 264201004563 dimerization interface [polypeptide binding]; other site 264201004564 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 264201004565 Domain of unknown function (DUF814); Region: DUF814; pfam05670 264201004566 F-box-like; Region: F-box-like; pfam12937 264201004567 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004568 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264201004569 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264201004570 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264201004571 active site 264201004572 DNA polymerase IV; Validated; Region: PRK02406 264201004573 DNA binding site [nucleotide binding] 264201004574 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 264201004575 Na binding site [ion binding]; other site 264201004576 BioY family; Region: BioY; pfam02632 264201004577 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 264201004578 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 264201004579 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264201004580 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264201004581 nucleoside/Zn binding site; other site 264201004582 dimer interface [polypeptide binding]; other site 264201004583 catalytic motif [active] 264201004584 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 264201004585 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 264201004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 264201004587 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201004588 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004589 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264201004590 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 264201004591 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264201004592 active site 264201004593 DNA binding site [nucleotide binding] 264201004594 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264201004595 DNA binding site [nucleotide binding] 264201004596 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 264201004597 nucleotide binding site [chemical binding]; other site 264201004598 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 264201004599 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 264201004600 AlkA N-terminal domain; Region: AlkA_N; pfam06029 264201004601 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 264201004602 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264201004603 minor groove reading motif; other site 264201004604 helix-hairpin-helix signature motif; other site 264201004605 substrate binding pocket [chemical binding]; other site 264201004606 active site 264201004607 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264201004608 DNA binding site [nucleotide binding] 264201004609 active site 264201004610 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 264201004611 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264201004612 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264201004613 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 264201004614 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 264201004615 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264201004616 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 264201004617 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 264201004618 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 264201004619 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264201004620 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 264201004621 L-aspartate oxidase; Provisional; Region: PRK06175 264201004622 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264201004623 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 264201004624 putative Iron-sulfur protein interface [polypeptide binding]; other site 264201004625 proximal heme binding site [chemical binding]; other site 264201004626 putative dimer interface [polypeptide binding]; other site 264201004627 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 264201004628 proximal heme binding site [chemical binding]; other site 264201004629 Iron-sulfur protein interface; other site 264201004630 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264201004631 active site 264201004632 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 264201004633 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 264201004634 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264201004635 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 264201004636 DsbD alpha interface [polypeptide binding]; other site 264201004637 catalytic residues [active] 264201004638 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 264201004639 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 264201004640 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 264201004641 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264201004642 translocation protein TolB; Provisional; Region: tolB; PRK01029 264201004643 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264201004644 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264201004645 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264201004646 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264201004647 ligand binding site [chemical binding]; other site 264201004648 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 264201004649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264201004650 glutamate racemase; Provisional; Region: PRK00865 264201004651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264201004652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264201004653 active site 264201004654 phosphorylation site [posttranslational modification] 264201004655 intermolecular recognition site; other site 264201004656 dimerization interface [polypeptide binding]; other site 264201004657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264201004658 DNA binding site [nucleotide binding] 264201004659 EamA-like transporter family; Region: EamA; pfam00892 264201004660 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264201004661 EamA-like transporter family; Region: EamA; pfam00892 264201004662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201004663 TPR motif; other site 264201004664 binding surface 264201004665 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 264201004666 Double zinc ribbon; Region: DZR; pfam12773 264201004667 Transglutaminase family; Region: Transglut_N; pfam00868 264201004668 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 264201004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201004670 S-adenosylmethionine binding site [chemical binding]; other site 264201004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264201004672 putative substrate translocation pore; other site 264201004673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264201004674 hypothetical protein; Provisional; Region: PRK05409 264201004675 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 264201004676 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 264201004677 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 264201004678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264201004679 catalytic core [active] 264201004680 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 264201004681 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 264201004682 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 264201004683 ADP binding site [chemical binding]; other site 264201004684 phosphagen binding site; other site 264201004685 substrate specificity loop; other site 264201004686 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 264201004687 UvrB/uvrC motif; Region: UVR; pfam02151 264201004688 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264201004689 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 264201004690 hinge region; other site 264201004691 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264201004692 putative nucleotide binding site [chemical binding]; other site 264201004693 uridine monophosphate binding site [chemical binding]; other site 264201004694 homohexameric interface [polypeptide binding]; other site 264201004695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264201004696 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 264201004697 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264201004698 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264201004699 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 264201004700 active site 264201004701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 264201004702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264201004703 putative active site [active] 264201004704 heme pocket [chemical binding]; other site 264201004705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264201004706 dimer interface [polypeptide binding]; other site 264201004707 phosphorylation site [posttranslational modification] 264201004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264201004709 ATP binding site [chemical binding]; other site 264201004710 Mg2+ binding site [ion binding]; other site 264201004711 G-X-G motif; other site 264201004712 MoxR-like ATPases [General function prediction only]; Region: COG0714 264201004713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264201004714 Walker A motif; other site 264201004715 ATP binding site [chemical binding]; other site 264201004716 Walker B motif; other site 264201004717 arginine finger; other site 264201004718 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264201004719 Protein of unknown function DUF58; Region: DUF58; pfam01882 264201004720 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264201004721 metal ion-dependent adhesion site (MIDAS); other site 264201004722 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 264201004723 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 264201004724 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 264201004725 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 264201004726 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 264201004727 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264201004728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201004729 Walker A/P-loop; other site 264201004730 ATP binding site [chemical binding]; other site 264201004731 Q-loop/lid; other site 264201004732 ABC transporter signature motif; other site 264201004733 Walker B; other site 264201004734 D-loop; other site 264201004735 H-loop/switch region; other site 264201004736 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264201004737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201004738 Walker A/P-loop; other site 264201004739 ATP binding site [chemical binding]; other site 264201004740 Q-loop/lid; other site 264201004741 ABC transporter signature motif; other site 264201004742 Walker B; other site 264201004743 D-loop; other site 264201004744 H-loop/switch region; other site 264201004745 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 264201004746 HlyD family secretion protein; Region: HlyD_3; pfam13437 264201004747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201004748 S-adenosylmethionine binding site [chemical binding]; other site 264201004749 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 264201004750 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 264201004751 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264201004752 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264201004753 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 264201004754 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264201004755 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 264201004756 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264201004757 Walker A motif; other site 264201004758 ATP binding site [chemical binding]; other site 264201004759 Walker B motif; other site 264201004760 type II secretion system protein D; Region: type_II_gspD; TIGR02517 264201004761 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264201004762 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264201004763 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 264201004764 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264201004765 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264201004766 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201004767 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 264201004768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 264201004769 BTB/POZ domain; Region: BTB; cl02518 264201004770 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004771 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004772 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004773 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004774 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004775 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264201004776 DNA binding site [nucleotide binding] 264201004777 active site 264201004778 Int/Topo IB signature motif; other site 264201004779 BTB/POZ domain; Region: BTB; cl02518 264201004780 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004781 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004782 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004783 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004784 Leucine rich repeat; Region: LRR_8; pfam13855 264201004785 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004786 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264201004787 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 264201004788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 264201004789 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 264201004790 BTB/POZ domain; Region: BTB; cl02518 264201004791 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004792 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004793 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004794 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004795 Leucine rich repeat; Region: LRR_8; pfam13855 264201004796 BTB/POZ domain; Region: BTB; cl02518 264201004797 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004798 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004799 Leucine rich repeat; Region: LRR_8; pfam13855 264201004800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264201004801 DNA binding site [nucleotide binding] 264201004802 active site 264201004803 Int/Topo IB signature motif; other site 264201004804 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264201004805 DNA binding site [nucleotide binding] 264201004806 active site 264201004807 Int/Topo IB signature motif; other site 264201004808 catalytic residues [active] 264201004809 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004810 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004811 BTB/POZ domain; Region: BTB; cl02518 264201004812 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004813 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004814 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 264201004815 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 264201004816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 264201004817 Walker A/P-loop; other site 264201004818 ATP binding site [chemical binding]; other site 264201004819 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 264201004820 F-box-like; Region: F-box-like; pfam12937 264201004821 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 264201004822 Zn binding site [ion binding]; other site 264201004823 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264201004824 DNA binding site [nucleotide binding] 264201004825 Int/Topo IB signature motif; other site 264201004826 active site 264201004827 catalytic residues [active] 264201004828 BTB/POZ domain; Region: BTB; cl02518 264201004829 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004830 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004831 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004832 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004833 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201004834 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004835 BTB/POZ domain; Region: BTB; cl02518 264201004836 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004837 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201004839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 264201004840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201004841 binding surface 264201004842 TPR motif; other site 264201004843 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 264201004844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201004845 binding surface 264201004846 TPR motif; other site 264201004847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264201004848 binding surface 264201004849 TPR motif; other site 264201004850 CHAT domain; Region: CHAT; pfam12770 264201004851 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 264201004852 Zn binding site [ion binding]; other site 264201004853 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 264201004854 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 264201004855 Transposase; Region: HTH_Tnp_1; cl17663 264201004856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264201004857 HTH-like domain; Region: HTH_21; pfam13276 264201004858 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 264201004859 Integrase core domain; Region: rve; pfam00665 264201004860 Integrase core domain; Region: rve_3; pfam13683 264201004861 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 264201004862 active site 264201004863 Zn binding site [ion binding]; other site 264201004864 AAA domain; Region: AAA_21; pfam13304 264201004865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 264201004866 Q-loop/lid; other site 264201004867 ABC transporter signature motif; other site 264201004868 Walker B; other site 264201004869 D-loop; other site 264201004870 H-loop/switch region; other site 264201004871 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 264201004872 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 264201004873 F-box-like; Region: F-box-like; pfam12937 264201004874 FOG: WD40 repeat [General function prediction only]; Region: COG2319 264201004875 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264201004876 structural tetrad; other site 264201004877 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 264201004878 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 264201004879 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 264201004880 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 264201004881 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 264201004882 Low-spin heme binding site [chemical binding]; other site 264201004883 D-pathway; other site 264201004884 Binuclear center (active site) [active] 264201004885 K-pathway; other site 264201004886 Putative proton exit pathway; other site 264201004887 HD domain; Region: HD_3; pfam13023 264201004888 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264201004889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264201004890 S-adenosylmethionine binding site [chemical binding]; other site 264201004891 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 264201004892 active site 264201004893 intersubunit interactions; other site 264201004894 catalytic residue [active] 264201004895 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264201004896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264201004897 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 264201004898 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264201004899 FMN binding site [chemical binding]; other site 264201004900 active site 264201004901 catalytic residues [active] 264201004902 substrate binding site [chemical binding]; other site 264201004903 YGGT family; Region: YGGT; pfam02325 264201004904 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 264201004905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264201004906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264201004907 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004908 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 264201004909 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004910 recombinase A; Provisional; Region: recA; PRK09354 264201004911 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264201004912 hexamer interface [polypeptide binding]; other site 264201004913 Walker A motif; other site 264201004914 ATP binding site [chemical binding]; other site 264201004915 Walker B motif; other site 264201004916 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264201004917 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264201004918 substrate binding pocket [chemical binding]; other site 264201004919 chain length determination region; other site 264201004920 substrate-Mg2+ binding site; other site 264201004921 catalytic residues [active] 264201004922 aspartate-rich region 1; other site 264201004923 active site lid residues [active] 264201004924 aspartate-rich region 2; other site 264201004925 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 264201004926 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 264201004927 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 264201004928 MgtC family; Region: MgtC; pfam02308 264201004929 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 264201004930 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 264201004931 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 264201004932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264201004933 active site 264201004934 motif I; other site 264201004935 motif II; other site 264201004936 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264201004937 ligand binding site [chemical binding]; other site 264201004938 active site 264201004939 UGI interface [polypeptide binding]; other site 264201004940 catalytic site [active] 264201004941 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 264201004942 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264201004943 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 264201004944 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 264201004945 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264201004946 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 264201004947 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264201004948 active site 264201004949 dimer interface [polypeptide binding]; other site 264201004950 motif 1; other site 264201004951 motif 2; other site 264201004952 motif 3; other site 264201004953 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264201004954 anticodon binding site; other site 264201004955 Fic/DOC family; Region: Fic; pfam02661 264201004956 Fic family protein [Function unknown]; Region: COG3177 264201004957 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201004958 Broad-Complex, Tramtrack and Bric a brac; Region: BTB; smart00225 264201004959 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004960 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004961 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 264201004962 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 264201004963 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 264201004964 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264201004965 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 264201004966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264201004967 non-specific DNA binding site [nucleotide binding]; other site 264201004968 salt bridge; other site 264201004969 sequence-specific DNA binding site [nucleotide binding]; other site