-- dump date   	20140619_024911
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
488538000001	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538000002	EamA-like transporter family; Region: EamA; pfam00892
488538000003	Predicted helicase [General function prediction only]; Region: COG4889
488538000004	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
488538000005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488538000006	ATP binding site [chemical binding]; other site
488538000007	putative Mg++ binding site [ion binding]; other site
488538000008	helicase superfamily c-terminal domain; Region: HELICc; smart00490
488538000009	Nuclease-related domain; Region: NERD; pfam08378
488538000010	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
488538000011	YcfA-like protein; Region: YcfA; pfam07927
488538000012	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
488538000013	Sel1-like repeats; Region: SEL1; smart00671
488538000014	Sel1-like repeats; Region: SEL1; smart00671
488538000015	Sel1-like repeats; Region: SEL1; smart00671
488538000016	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
488538000017	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
488538000018	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
488538000019	Transcriptional regulator; Region: Rrf2; pfam02082
488538000020	Transcriptional regulator; Region: Rrf2; cl17282
488538000021	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
488538000022	putative ABC transporter; Region: ycf24; CHL00085
488538000023	FeS assembly ATPase SufC; Region: sufC; TIGR01978
488538000024	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
488538000025	Walker A/P-loop; other site
488538000026	ATP binding site [chemical binding]; other site
488538000027	Q-loop/lid; other site
488538000028	ABC transporter signature motif; other site
488538000029	Walker B; other site
488538000030	D-loop; other site
488538000031	H-loop/switch region; other site
488538000032	FeS assembly protein SufD; Region: sufD; TIGR01981
488538000033	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
488538000034	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
488538000035	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
488538000036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538000037	catalytic residue [active]
488538000038	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
488538000039	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
488538000040	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488538000041	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
488538000042	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538000043	Walker A/P-loop; other site
488538000044	ATP binding site [chemical binding]; other site
488538000045	Q-loop/lid; other site
488538000046	ABC transporter signature motif; other site
488538000047	Walker B; other site
488538000048	D-loop; other site
488538000049	H-loop/switch region; other site
488538000050	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
488538000051	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
488538000052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538000053	putative substrate translocation pore; other site
488538000054	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538000055	Cupin domain; Region: Cupin_2; cl17218
488538000056	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
488538000057	ATP-NAD kinase; Region: NAD_kinase; pfam01513
488538000058	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
488538000059	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
488538000060	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
488538000061	GTP binding site; other site
488538000062	KpsF/GutQ family protein; Region: kpsF; TIGR00393
488538000063	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
488538000064	putative active site [active]
488538000065	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
488538000066	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
488538000067	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
488538000068	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
488538000069	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
488538000070	epoxyqueuosine reductase; Region: TIGR00276
488538000071	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
488538000072	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
488538000073	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538000074	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
488538000075	putative C-terminal domain interface [polypeptide binding]; other site
488538000076	putative GSH binding site (G-site) [chemical binding]; other site
488538000077	putative dimer interface [polypeptide binding]; other site
488538000078	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
488538000079	putative N-terminal domain interface [polypeptide binding]; other site
488538000080	putative dimer interface [polypeptide binding]; other site
488538000081	putative substrate binding pocket (H-site) [chemical binding]; other site
488538000082	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
488538000083	homotrimer interaction site [polypeptide binding]; other site
488538000084	putative active site [active]
488538000085	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
488538000086	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
488538000087	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
488538000088	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538000089	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
488538000090	substrate binding site [chemical binding]; other site
488538000091	ATP binding site [chemical binding]; other site
488538000092	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
488538000093	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538000094	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538000095	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538000096	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538000097	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488538000098	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488538000099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538000100	dimer interface [polypeptide binding]; other site
488538000101	conserved gate region; other site
488538000102	putative PBP binding loops; other site
488538000103	ABC-ATPase subunit interface; other site
488538000104	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488538000105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538000106	dimer interface [polypeptide binding]; other site
488538000107	conserved gate region; other site
488538000108	putative PBP binding loops; other site
488538000109	ABC-ATPase subunit interface; other site
488538000110	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
488538000111	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
488538000112	Walker A/P-loop; other site
488538000113	ATP binding site [chemical binding]; other site
488538000114	Q-loop/lid; other site
488538000115	ABC transporter signature motif; other site
488538000116	Walker B; other site
488538000117	D-loop; other site
488538000118	H-loop/switch region; other site
488538000119	TOBE domain; Region: TOBE_2; pfam08402
488538000120	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538000121	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
488538000122	histidinol dehydrogenase; Region: hisD; TIGR00069
488538000123	NAD binding site [chemical binding]; other site
488538000124	dimerization interface [polypeptide binding]; other site
488538000125	product binding site; other site
488538000126	substrate binding site [chemical binding]; other site
488538000127	zinc binding site [ion binding]; other site
488538000128	catalytic residues [active]
488538000129	short chain dehydrogenase; Provisional; Region: PRK07060
488538000130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538000131	NAD(P) binding site [chemical binding]; other site
488538000132	active site
488538000133	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488538000134	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488538000135	DNA binding site [nucleotide binding]
488538000136	domain linker motif; other site
488538000137	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
488538000138	putative dimerization interface [polypeptide binding]; other site
488538000139	putative ligand binding site [chemical binding]; other site
488538000140	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538000141	SnoaL-like domain; Region: SnoaL_2; pfam12680
488538000142	Cupin domain; Region: Cupin_2; pfam07883
488538000143	Mif2/CENP-C like; Region: Mif2; pfam11699
488538000144	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
488538000145	substrate binding site [chemical binding]; other site
488538000146	THF binding site; other site
488538000147	zinc-binding site [ion binding]; other site
488538000148	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
488538000149	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
488538000150	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488538000151	DNA-binding site [nucleotide binding]; DNA binding site
488538000152	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
488538000153	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538000154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538000155	homodimer interface [polypeptide binding]; other site
488538000156	catalytic residue [active]
488538000157	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538000158	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
488538000159	NAD(P) binding site [chemical binding]; other site
488538000160	catalytic residues [active]
488538000161	Epoxide hydrolase N terminus; Region: EHN; pfam06441
488538000162	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
488538000163	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
488538000164	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538000165	DctM-like transporters; Region: DctM; pfam06808
488538000166	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
488538000167	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
488538000168	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
488538000169	hypothetical protein; Provisional; Region: PRK07538
488538000170	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538000171	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
488538000172	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488538000173	substrate binding pocket [chemical binding]; other site
488538000174	membrane-bound complex binding site; other site
488538000175	hinge residues; other site
488538000176	beta-ketothiolase; Provisional; Region: PRK09051
488538000177	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
488538000178	dimer interface [polypeptide binding]; other site
488538000179	active site
488538000180	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
488538000181	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538000182	Walker A/P-loop; other site
488538000183	ATP binding site [chemical binding]; other site
488538000184	Q-loop/lid; other site
488538000185	ABC transporter signature motif; other site
488538000186	Walker B; other site
488538000187	D-loop; other site
488538000188	H-loop/switch region; other site
488538000189	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488538000190	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538000191	Walker A/P-loop; other site
488538000192	ATP binding site [chemical binding]; other site
488538000193	Q-loop/lid; other site
488538000194	ABC transporter signature motif; other site
488538000195	Walker B; other site
488538000196	D-loop; other site
488538000197	H-loop/switch region; other site
488538000198	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488538000199	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
488538000200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538000201	dimer interface [polypeptide binding]; other site
488538000202	conserved gate region; other site
488538000203	putative PBP binding loops; other site
488538000204	ABC-ATPase subunit interface; other site
488538000205	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
488538000206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538000207	dimer interface [polypeptide binding]; other site
488538000208	conserved gate region; other site
488538000209	putative PBP binding loops; other site
488538000210	ABC-ATPase subunit interface; other site
488538000211	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
488538000212	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
488538000213	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
488538000214	active site pocket [active]
488538000215	oxyanion hole [active]
488538000216	catalytic triad [active]
488538000217	active site nucleophile [active]
488538000218	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
488538000219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538000220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538000221	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
488538000222	dimerization interface [polypeptide binding]; other site
488538000223	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488538000224	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
488538000225	phosphate binding site [ion binding]; other site
488538000226	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
488538000227	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538000228	PYR/PP interface [polypeptide binding]; other site
488538000229	dimer interface [polypeptide binding]; other site
488538000230	TPP binding site [chemical binding]; other site
488538000231	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538000232	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
488538000233	TPP-binding site; other site
488538000234	dimer interface [polypeptide binding]; other site
488538000235	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
488538000236	active site
488538000237	homotetramer interface [polypeptide binding]; other site
488538000238	putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486
488538000239	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538000240	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
488538000241	ferrochelatase; Reviewed; Region: hemH; PRK00035
488538000242	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
488538000243	C-terminal domain interface [polypeptide binding]; other site
488538000244	active site
488538000245	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
488538000246	active site
488538000247	N-terminal domain interface [polypeptide binding]; other site
488538000248	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
488538000249	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
488538000250	dimer interface [polypeptide binding]; other site
488538000251	decamer (pentamer of dimers) interface [polypeptide binding]; other site
488538000252	catalytic triad [active]
488538000253	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
488538000254	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
488538000255	substrate-cofactor binding pocket; other site
488538000256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538000257	catalytic residue [active]
488538000258	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538000259	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
488538000260	catalytic loop [active]
488538000261	iron binding site [ion binding]; other site
488538000262	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
488538000263	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
488538000264	[4Fe-4S] binding site [ion binding]; other site
488538000265	molybdopterin cofactor binding site; other site
488538000266	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
488538000267	molybdopterin cofactor binding site; other site
488538000268	NADH dehydrogenase subunit E; Validated; Region: PRK07539
488538000269	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
488538000270	putative dimer interface [polypeptide binding]; other site
488538000271	[2Fe-2S] cluster binding site [ion binding]; other site
488538000272	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
488538000273	SLBB domain; Region: SLBB; pfam10531
488538000274	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
488538000275	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
488538000276	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488538000277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538000278	active site
488538000279	phosphorylation site [posttranslational modification]
488538000280	intermolecular recognition site; other site
488538000281	dimerization interface [polypeptide binding]; other site
488538000282	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538000283	DNA binding site [nucleotide binding]
488538000284	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
488538000285	recombinase A; Provisional; Region: recA; PRK09354
488538000286	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
488538000287	hexamer interface [polypeptide binding]; other site
488538000288	Walker A motif; other site
488538000289	ATP binding site [chemical binding]; other site
488538000290	Walker B motif; other site
488538000291	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
488538000292	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
488538000293	motif 1; other site
488538000294	active site
488538000295	motif 2; other site
488538000296	motif 3; other site
488538000297	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
488538000298	isocitrate dehydrogenase; Validated; Region: PRK08299
488538000299	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
488538000300	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
488538000301	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
488538000302	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
488538000303	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
488538000304	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
488538000305	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
488538000306	methionine sulfoxide reductase B; Provisional; Region: PRK00222
488538000307	SelR domain; Region: SelR; pfam01641
488538000308	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
488538000309	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
488538000310	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
488538000311	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
488538000312	shikimate binding site; other site
488538000313	NAD(P) binding site [chemical binding]; other site
488538000314	GcrA cell cycle regulator; Region: GcrA; cl11564
488538000315	aminopeptidase N; Provisional; Region: pepN; PRK14015
488538000316	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
488538000317	Zn binding site [ion binding]; other site
488538000318	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
488538000319	DEAD-like helicases superfamily; Region: DEXDc; smart00487
488538000320	ATP binding site [chemical binding]; other site
488538000321	Mg++ binding site [ion binding]; other site
488538000322	motif III; other site
488538000323	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538000324	nucleotide binding region [chemical binding]; other site
488538000325	ATP-binding site [chemical binding]; other site
488538000326	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
488538000327	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
488538000328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538000329	ATP binding site [chemical binding]; other site
488538000330	Mg2+ binding site [ion binding]; other site
488538000331	G-X-G motif; other site
488538000332	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
488538000333	anchoring element; other site
488538000334	dimer interface [polypeptide binding]; other site
488538000335	ATP binding site [chemical binding]; other site
488538000336	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
488538000337	active site
488538000338	metal binding site [ion binding]; metal-binding site
488538000339	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
488538000340	glutamine synthetase; Provisional; Region: glnA; PRK09469
488538000341	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
488538000342	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
488538000343	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
488538000344	Nitrogen regulatory protein P-II; Region: P-II; smart00938
488538000345	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
488538000346	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
488538000347	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
488538000348	putative active site [active]
488538000349	N-formylglutamate amidohydrolase; Region: FGase; cl01522
488538000350	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
488538000351	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
488538000352	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538000353	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
488538000354	DctM-like transporters; Region: DctM; pfam06808
488538000355	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
488538000356	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
488538000357	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
488538000358	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538000359	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
488538000360	NAD(P) binding site [chemical binding]; other site
488538000361	catalytic residues [active]
488538000362	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
488538000363	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
488538000364	putative active site [active]
488538000365	metal binding site [ion binding]; metal-binding site
488538000366	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538000367	EamA-like transporter family; Region: EamA; pfam00892
488538000368	EamA-like transporter family; Region: EamA; pfam00892
488538000369	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
488538000370	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
488538000371	active site
488538000372	catalytic site [active]
488538000373	substrate binding site [chemical binding]; other site
488538000374	FOG: CBS domain [General function prediction only]; Region: COG0517
488538000375	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
488538000376	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
488538000377	metal binding triad; other site
488538000378	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
488538000379	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
488538000380	Ligand Binding Site [chemical binding]; other site
488538000381	trigger factor; Provisional; Region: tig; PRK01490
488538000382	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
488538000383	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
488538000384	Clp protease; Region: CLP_protease; pfam00574
488538000385	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
488538000386	oligomer interface [polypeptide binding]; other site
488538000387	active site residues [active]
488538000388	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
488538000389	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
488538000390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538000391	Walker A motif; other site
488538000392	ATP binding site [chemical binding]; other site
488538000393	Walker B motif; other site
488538000394	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
488538000395	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
488538000396	Found in ATP-dependent protease La (LON); Region: LON; smart00464
488538000397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538000398	Walker A motif; other site
488538000399	ATP binding site [chemical binding]; other site
488538000400	Walker B motif; other site
488538000401	arginine finger; other site
488538000402	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
488538000403	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
488538000404	IHF dimer interface [polypeptide binding]; other site
488538000405	IHF - DNA interface [nucleotide binding]; other site
488538000406	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
488538000407	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
488538000408	putative dimer interface [polypeptide binding]; other site
488538000409	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
488538000410	putative substrate binding site [chemical binding]; other site
488538000411	putative ATP binding site [chemical binding]; other site
488538000412	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538000413	EamA-like transporter family; Region: EamA; pfam00892
488538000414	Predicted membrane protein [Function unknown]; Region: COG2364
488538000415	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
488538000416	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
488538000417	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
488538000418	ArsC family; Region: ArsC; pfam03960
488538000419	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585
488538000420	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585
488538000421	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538000422	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
488538000423	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538000424	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
488538000425	NADH dehydrogenase subunit B; Validated; Region: PRK06411
488538000426	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
488538000427	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
488538000428	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
488538000429	NADH dehydrogenase subunit D; Validated; Region: PRK06075
488538000430	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
488538000431	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
488538000432	putative dimer interface [polypeptide binding]; other site
488538000433	[2Fe-2S] cluster binding site [ion binding]; other site
488538000434	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
488538000435	SLBB domain; Region: SLBB; pfam10531
488538000436	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
488538000437	NADH dehydrogenase subunit G; Validated; Region: PRK09130
488538000438	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538000439	catalytic loop [active]
488538000440	iron binding site [ion binding]; other site
488538000441	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
488538000442	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
488538000443	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
488538000444	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
488538000445	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
488538000446	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
488538000447	4Fe-4S binding domain; Region: Fer4; pfam00037
488538000448	4Fe-4S binding domain; Region: Fer4; pfam00037
488538000449	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
488538000450	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
488538000451	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
488538000452	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
488538000453	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
488538000454	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
488538000455	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
488538000456	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
488538000457	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
488538000458	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
488538000459	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
488538000460	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
488538000461	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
488538000462	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
488538000463	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
488538000464	pantothenate kinase; Reviewed; Region: PRK13318
488538000465	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
488538000466	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
488538000467	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
488538000468	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488538000469	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
488538000470	dimer interface [polypeptide binding]; other site
488538000471	substrate binding site [chemical binding]; other site
488538000472	metal binding site [ion binding]; metal-binding site
488538000473	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
488538000474	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
488538000475	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
488538000476	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
488538000477	dimer interface [polypeptide binding]; other site
488538000478	active site
488538000479	glycine-pyridoxal phosphate binding site [chemical binding]; other site
488538000480	folate binding site [chemical binding]; other site
488538000481	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
488538000482	ATP cone domain; Region: ATP-cone; pfam03477
488538000483	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
488538000484	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
488538000485	catalytic motif [active]
488538000486	Zn binding site [ion binding]; other site
488538000487	RibD C-terminal domain; Region: RibD_C; cl17279
488538000488	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
488538000489	Lumazine binding domain; Region: Lum_binding; pfam00677
488538000490	Lumazine binding domain; Region: Lum_binding; pfam00677
488538000491	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
488538000492	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
488538000493	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
488538000494	dimerization interface [polypeptide binding]; other site
488538000495	active site
488538000496	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
488538000497	homopentamer interface [polypeptide binding]; other site
488538000498	active site
488538000499	transcription antitermination factor NusB; Region: nusB; TIGR01951
488538000500	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
488538000501	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
488538000502	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
488538000503	putative phosphate acyltransferase; Provisional; Region: PRK05331
488538000504	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
488538000505	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
488538000506	dimer interface [polypeptide binding]; other site
488538000507	active site
488538000508	CoA binding pocket [chemical binding]; other site
488538000509	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
488538000510	IHF dimer interface [polypeptide binding]; other site
488538000511	IHF - DNA interface [nucleotide binding]; other site
488538000512	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
488538000513	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
488538000514	DNA binding residues [nucleotide binding]
488538000515	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538000516	active site
488538000517	DNA binding site [nucleotide binding]
488538000518	Int/Topo IB signature motif; other site
488538000519	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
488538000520	active site
488538000521	metal binding site [ion binding]; metal-binding site
488538000522	interdomain interaction site; other site
488538000523	AAA domain; Region: AAA_25; pfam13481
488538000524	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488538000525	Walker A motif; other site
488538000526	ATP binding site [chemical binding]; other site
488538000527	Walker B motif; other site
488538000528	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
488538000529	diiron binding motif [ion binding]; other site
488538000530	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
488538000531	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
488538000532	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
488538000533	ligand binding site [chemical binding]; other site
488538000534	DEAD-like helicases superfamily; Region: DEXDc; smart00487
488538000535	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488538000536	ATP binding site [chemical binding]; other site
488538000537	putative Mg++ binding site [ion binding]; other site
488538000538	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538000539	nucleotide binding region [chemical binding]; other site
488538000540	ATP-binding site [chemical binding]; other site
488538000541	Restriction endonuclease; Region: Mrr_cat; pfam04471
488538000542	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
488538000543	PDZ domain; Region: PDZ_2; pfam13180
488538000544	HEAT repeats; Region: HEAT_2; pfam13646
488538000545	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538000546	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538000547	EamA-like transporter family; Region: EamA; pfam00892
488538000548	EamA-like transporter family; Region: EamA; cl17759
488538000549	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
488538000550	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
488538000551	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
488538000552	acyl-activating enzyme (AAE) consensus motif; other site
488538000553	acyl-activating enzyme (AAE) consensus motif; other site
488538000554	putative AMP binding site [chemical binding]; other site
488538000555	putative active site [active]
488538000556	putative CoA binding site [chemical binding]; other site
488538000557	anthranilate synthase component I; Provisional; Region: PRK13573
488538000558	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
488538000559	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
488538000560	periplasmic folding chaperone; Provisional; Region: PRK10788
488538000561	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
488538000562	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
488538000563	triosephosphate isomerase; Provisional; Region: PRK14565
488538000564	substrate binding site [chemical binding]; other site
488538000565	dimer interface [polypeptide binding]; other site
488538000566	catalytic triad [active]
488538000567	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
488538000568	CTP synthetase; Validated; Region: pyrG; PRK05380
488538000569	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
488538000570	Catalytic site [active]
488538000571	active site
488538000572	UTP binding site [chemical binding]; other site
488538000573	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
488538000574	active site
488538000575	putative oxyanion hole; other site
488538000576	catalytic triad [active]
488538000577	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
488538000578	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
488538000579	enolase; Provisional; Region: eno; PRK00077
488538000580	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
488538000581	dimer interface [polypeptide binding]; other site
488538000582	metal binding site [ion binding]; metal-binding site
488538000583	substrate binding pocket [chemical binding]; other site
488538000584	Septum formation initiator; Region: DivIC; cl17659
488538000585	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
488538000586	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
488538000587	tetramer interface [polypeptide binding]; other site
488538000588	TPP-binding site [chemical binding]; other site
488538000589	heterodimer interface [polypeptide binding]; other site
488538000590	phosphorylation loop region [posttranslational modification]
488538000591	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
488538000592	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
488538000593	E3 interaction surface; other site
488538000594	lipoyl attachment site [posttranslational modification]; other site
488538000595	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
488538000596	alpha subunit interface [polypeptide binding]; other site
488538000597	TPP binding site [chemical binding]; other site
488538000598	heterodimer interface [polypeptide binding]; other site
488538000599	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
488538000600	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
488538000601	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
488538000602	E3 interaction surface; other site
488538000603	lipoyl attachment site [posttranslational modification]; other site
488538000604	e3 binding domain; Region: E3_binding; pfam02817
488538000605	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
488538000606	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
488538000607	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538000608	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538000609	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488538000610	lipoyl synthase; Provisional; Region: PRK05481
488538000611	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488538000612	FeS/SAM binding site; other site
488538000613	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
488538000614	putative coenzyme Q binding site [chemical binding]; other site
488538000615	Competence-damaged protein; Region: CinA; pfam02464
488538000616	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
488538000617	tetramer interfaces [polypeptide binding]; other site
488538000618	binuclear metal-binding site [ion binding]; other site
488538000619	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
488538000620	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
488538000621	substrate binding site; other site
488538000622	dimer interface; other site
488538000623	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
488538000624	homotrimer interaction site [polypeptide binding]; other site
488538000625	zinc binding site [ion binding]; other site
488538000626	CDP-binding sites; other site
488538000627	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
488538000628	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
488538000629	FMN binding site [chemical binding]; other site
488538000630	active site
488538000631	catalytic residues [active]
488538000632	substrate binding site [chemical binding]; other site
488538000633	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
488538000634	PAS domain; Region: PAS; smart00091
488538000635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538000636	dimer interface [polypeptide binding]; other site
488538000637	phosphorylation site [posttranslational modification]
488538000638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538000639	ATP binding site [chemical binding]; other site
488538000640	Mg2+ binding site [ion binding]; other site
488538000641	G-X-G motif; other site
488538000642	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
488538000643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538000644	active site
488538000645	phosphorylation site [posttranslational modification]
488538000646	intermolecular recognition site; other site
488538000647	dimerization interface [polypeptide binding]; other site
488538000648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538000649	Walker A motif; other site
488538000650	ATP binding site [chemical binding]; other site
488538000651	Walker B motif; other site
488538000652	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
488538000653	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
488538000654	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488538000655	dimerization interface [polypeptide binding]; other site
488538000656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538000657	dimer interface [polypeptide binding]; other site
488538000658	phosphorylation site [posttranslational modification]
488538000659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538000660	ATP binding site [chemical binding]; other site
488538000661	Mg2+ binding site [ion binding]; other site
488538000662	G-X-G motif; other site
488538000663	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
488538000664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538000665	active site
488538000666	phosphorylation site [posttranslational modification]
488538000667	intermolecular recognition site; other site
488538000668	dimerization interface [polypeptide binding]; other site
488538000669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538000670	Walker A motif; other site
488538000671	ATP binding site [chemical binding]; other site
488538000672	Walker B motif; other site
488538000673	arginine finger; other site
488538000674	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
488538000675	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
488538000676	TrkA-N domain; Region: TrkA_N; pfam02254
488538000677	TrkA-C domain; Region: TrkA_C; pfam02080
488538000678	TrkA-N domain; Region: TrkA_N; pfam02254
488538000679	TrkA-C domain; Region: TrkA_C; pfam02080
488538000680	bacterial Hfq-like; Region: Hfq; cd01716
488538000681	hexamer interface [polypeptide binding]; other site
488538000682	Sm1 motif; other site
488538000683	RNA binding site [nucleotide binding]; other site
488538000684	Sm2 motif; other site
488538000685	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
488538000686	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
488538000687	active site
488538000688	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
488538000689	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
488538000690	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
488538000691	homodimer interface [polypeptide binding]; other site
488538000692	metal binding site [ion binding]; metal-binding site
488538000693	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
488538000694	homodimer interface [polypeptide binding]; other site
488538000695	active site
488538000696	putative chemical substrate binding site [chemical binding]; other site
488538000697	metal binding site [ion binding]; metal-binding site
488538000698	Uncharacterized conserved protein [Function unknown]; Region: COG2928
488538000699	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
488538000700	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
488538000701	generic binding surface II; other site
488538000702	ssDNA binding site; other site
488538000703	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488538000704	ATP binding site [chemical binding]; other site
488538000705	putative Mg++ binding site [ion binding]; other site
488538000706	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538000707	nucleotide binding region [chemical binding]; other site
488538000708	ATP-binding site [chemical binding]; other site
488538000709	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
488538000710	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
488538000711	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
488538000712	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488538000713	ATP binding site [chemical binding]; other site
488538000714	putative Mg++ binding site [ion binding]; other site
488538000715	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538000716	nucleotide binding region [chemical binding]; other site
488538000717	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
488538000718	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
488538000719	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
488538000720	catalytic residues [active]
488538000721	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
488538000722	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538000723	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
488538000724	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
488538000725	dimer interface [polypeptide binding]; other site
488538000726	N-terminal domain interface [polypeptide binding]; other site
488538000727	substrate binding pocket (H-site) [chemical binding]; other site
488538000728	aminodeoxychorismate synthase; Provisional; Region: PRK07508
488538000729	chorismate binding enzyme; Region: Chorismate_bind; cl10555
488538000730	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
488538000731	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
488538000732	glutamine binding [chemical binding]; other site
488538000733	catalytic triad [active]
488538000734	hypothetical protein; Provisional; Region: PRK07546
488538000735	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
488538000736	substrate-cofactor binding pocket; other site
488538000737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538000738	catalytic residue [active]
488538000739	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
488538000740	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538000741	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538000742	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
488538000743	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
488538000744	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
488538000745	FMN-binding pocket [chemical binding]; other site
488538000746	flavin binding motif; other site
488538000747	phosphate binding motif [ion binding]; other site
488538000748	beta-alpha-beta structure motif; other site
488538000749	NAD binding pocket [chemical binding]; other site
488538000750	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538000751	catalytic loop [active]
488538000752	iron binding site [ion binding]; other site
488538000753	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
488538000754	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
488538000755	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
488538000756	conserved cys residue [active]
488538000757	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488538000758	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488538000759	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538000760	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
488538000761	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
488538000762	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538000763	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
488538000764	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
488538000765	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538000766	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538000767	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
488538000768	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
488538000769	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488538000770	DNA-binding site [nucleotide binding]; DNA binding site
488538000771	UTRA domain; Region: UTRA; pfam07702
488538000772	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
488538000773	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
488538000774	active site
488538000775	dimer interface [polypeptide binding]; other site
488538000776	non-prolyl cis peptide bond; other site
488538000777	insertion regions; other site
488538000778	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
488538000779	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
488538000780	active site
488538000781	catalytic tetrad [active]
488538000782	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
488538000783	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
488538000784	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
488538000785	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
488538000786	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538000787	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
488538000788	acetylornithine deacetylase; Provisional; Region: PRK07522
488538000789	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
488538000790	metal binding site [ion binding]; metal-binding site
488538000791	putative dimer interface [polypeptide binding]; other site
488538000792	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
488538000793	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
488538000794	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
488538000795	[2Fe-2S] cluster binding site [ion binding]; other site
488538000796	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
488538000797	putative alpha subunit interface [polypeptide binding]; other site
488538000798	putative active site [active]
488538000799	putative substrate binding site [chemical binding]; other site
488538000800	Fe binding site [ion binding]; other site
488538000801	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
488538000802	homotrimer interaction site [polypeptide binding]; other site
488538000803	putative active site [active]
488538000804	4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794
488538000805	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
488538000806	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538000807	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538000808	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
488538000809	putative substrate binding pocket [chemical binding]; other site
488538000810	dimerization interface [polypeptide binding]; other site
488538000811	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
488538000812	Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
488538000813	EamA-like transporter family; Region: EamA; pfam00892
488538000814	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538000815	EamA-like transporter family; Region: EamA; pfam00892
488538000816	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
488538000817	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
488538000818	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
488538000819	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
488538000820	intersubunit interface [polypeptide binding]; other site
488538000821	active site
488538000822	Zn2+ binding site [ion binding]; other site
488538000823	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538000824	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538000825	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538000826	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538000827	xylose isomerase; Provisional; Region: PRK05474
488538000828	xylose isomerase; Region: xylose_isom_A; TIGR02630
488538000829	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
488538000830	N- and C-terminal domain interface [polypeptide binding]; other site
488538000831	D-xylulose kinase; Region: XylB; TIGR01312
488538000832	active site
488538000833	MgATP binding site [chemical binding]; other site
488538000834	catalytic site [active]
488538000835	metal binding site [ion binding]; metal-binding site
488538000836	xylulose binding site [chemical binding]; other site
488538000837	homodimer interface [polypeptide binding]; other site
488538000838	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538000839	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538000840	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
488538000841	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538000842	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538000843	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
488538000844	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
488538000845	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
488538000846	putative ligand binding site [chemical binding]; other site
488538000847	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
488538000848	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
488538000849	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
488538000850	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538000851	TM-ABC transporter signature motif; other site
488538000852	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538000853	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
488538000854	Walker A/P-loop; other site
488538000855	ATP binding site [chemical binding]; other site
488538000856	Q-loop/lid; other site
488538000857	ABC transporter signature motif; other site
488538000858	Walker B; other site
488538000859	D-loop; other site
488538000860	H-loop/switch region; other site
488538000861	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
488538000862	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
488538000863	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
488538000864	putative active site [active]
488538000865	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538000866	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
488538000867	substrate binding site [chemical binding]; other site
488538000868	ATP binding site [chemical binding]; other site
488538000869	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
488538000870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
488538000871	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
488538000872	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538000873	PYR/PP interface [polypeptide binding]; other site
488538000874	dimer interface [polypeptide binding]; other site
488538000875	TPP binding site [chemical binding]; other site
488538000876	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538000877	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
488538000878	TPP-binding site [chemical binding]; other site
488538000879	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
488538000880	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
488538000881	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
488538000882	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
488538000883	Metal-binding active site; metal-binding site
488538000884	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
488538000885	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538000886	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
488538000887	substrate binding site [chemical binding]; other site
488538000888	ATP binding site [chemical binding]; other site
488538000889	KduI/IolB family; Region: KduI; pfam04962
488538000890	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
488538000891	active site
488538000892	intersubunit interface [polypeptide binding]; other site
488538000893	zinc binding site [ion binding]; other site
488538000894	Na+ binding site [ion binding]; other site
488538000895	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
488538000896	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
488538000897	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
488538000898	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
488538000899	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
488538000900	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
488538000901	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
488538000902	acyl-activating enzyme (AAE) consensus motif; other site
488538000903	acyl-activating enzyme (AAE) consensus motif; other site
488538000904	putative AMP binding site [chemical binding]; other site
488538000905	putative active site [active]
488538000906	putative CoA binding site [chemical binding]; other site
488538000907	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
488538000908	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
488538000909	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
488538000910	active site
488538000911	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
488538000912	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
488538000913	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
488538000914	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
488538000915	N-acetyl-D-glucosamine binding site [chemical binding]; other site
488538000916	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
488538000917	AzlC protein; Region: AzlC; pfam03591
488538000918	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
488538000919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
488538000920	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
488538000921	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
488538000922	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
488538000923	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
488538000924	Transcriptional regulator [Transcription]; Region: IclR; COG1414
488538000925	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
488538000926	Bacterial transcriptional regulator; Region: IclR; pfam01614
488538000927	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
488538000928	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
488538000929	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538000930	catalytic loop [active]
488538000931	iron binding site [ion binding]; other site
488538000932	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
488538000933	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
488538000934	active site residue [active]
488538000935	acyl-CoA synthetase; Validated; Region: PRK08162
488538000936	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
488538000937	acyl-activating enzyme (AAE) consensus motif; other site
488538000938	putative active site [active]
488538000939	AMP binding site [chemical binding]; other site
488538000940	putative CoA binding site [chemical binding]; other site
488538000941	short chain dehydrogenase; Provisional; Region: PRK06138
488538000942	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
488538000943	NAD binding site [chemical binding]; other site
488538000944	homotetramer interface [polypeptide binding]; other site
488538000945	homodimer interface [polypeptide binding]; other site
488538000946	active site
488538000947	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
488538000948	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
488538000949	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
488538000950	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
488538000951	active site pocket [active]
488538000952	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488538000953	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538000954	Walker A/P-loop; other site
488538000955	ATP binding site [chemical binding]; other site
488538000956	Q-loop/lid; other site
488538000957	ABC transporter signature motif; other site
488538000958	Walker B; other site
488538000959	D-loop; other site
488538000960	H-loop/switch region; other site
488538000961	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488538000962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538000963	dimer interface [polypeptide binding]; other site
488538000964	conserved gate region; other site
488538000965	putative PBP binding loops; other site
488538000966	ABC-ATPase subunit interface; other site
488538000967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538000968	dimer interface [polypeptide binding]; other site
488538000969	conserved gate region; other site
488538000970	putative PBP binding loops; other site
488538000971	ABC-ATPase subunit interface; other site
488538000972	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488538000973	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488538000974	substrate binding pocket [chemical binding]; other site
488538000975	membrane-bound complex binding site; other site
488538000976	hinge residues; other site
488538000977	Transcriptional regulators [Transcription]; Region: GntR; COG1802
488538000978	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488538000979	DNA-binding site [nucleotide binding]; DNA binding site
488538000980	FCD domain; Region: FCD; pfam07729
488538000981	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
488538000982	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
488538000983	inhibitor site; inhibition site
488538000984	active site
488538000985	dimer interface [polypeptide binding]; other site
488538000986	catalytic residue [active]
488538000987	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538000988	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
488538000989	NAD(P) binding site [chemical binding]; other site
488538000990	catalytic residues [active]
488538000991	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
488538000992	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
488538000993	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
488538000994	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
488538000995	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
488538000996	Moco binding site; other site
488538000997	metal coordination site [ion binding]; other site
488538000998	dimerization interface [polypeptide binding]; other site
488538000999	tartrate dehydrogenase; Region: TTC; TIGR02089
488538001000	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
488538001001	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
488538001002	tricarballylate utilization protein B; Provisional; Region: PRK15033
488538001003	tricarballylate utilization protein B; Provisional; Region: PRK15033
488538001004	CitB domain protein; Region: CitB; TIGR02484
488538001005	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
488538001006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488538001007	DNA-binding site [nucleotide binding]; DNA binding site
488538001008	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
488538001009	UTRA domain; Region: UTRA; pfam07702
488538001010	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
488538001011	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
488538001012	active site
488538001013	imidazolonepropionase; Validated; Region: PRK09356
488538001014	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
488538001015	active site
488538001016	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
488538001017	active sites [active]
488538001018	tetramer interface [polypeptide binding]; other site
488538001019	urocanate hydratase; Provisional; Region: PRK05414
488538001020	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
488538001021	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
488538001022	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
488538001023	N-terminal domain interface [polypeptide binding]; other site
488538001024	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488538001025	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488538001026	Walker A/P-loop; other site
488538001027	ATP binding site [chemical binding]; other site
488538001028	Q-loop/lid; other site
488538001029	ABC transporter signature motif; other site
488538001030	Walker B; other site
488538001031	D-loop; other site
488538001032	H-loop/switch region; other site
488538001033	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488538001034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001035	dimer interface [polypeptide binding]; other site
488538001036	conserved gate region; other site
488538001037	putative PBP binding loops; other site
488538001038	ABC-ATPase subunit interface; other site
488538001039	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488538001040	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488538001041	substrate binding pocket [chemical binding]; other site
488538001042	membrane-bound complex binding site; other site
488538001043	hinge residues; other site
488538001044	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488538001045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001046	dimer interface [polypeptide binding]; other site
488538001047	conserved gate region; other site
488538001048	putative PBP binding loops; other site
488538001049	ABC-ATPase subunit interface; other site
488538001050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538001051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538001052	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
488538001053	dimerization interface [polypeptide binding]; other site
488538001054	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
488538001055	TPP-binding site [chemical binding]; other site
488538001056	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
488538001057	PYR/PP interface [polypeptide binding]; other site
488538001058	dimer interface [polypeptide binding]; other site
488538001059	TPP binding site [chemical binding]; other site
488538001060	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
488538001061	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538001062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001063	homodimer interface [polypeptide binding]; other site
488538001064	catalytic residue [active]
488538001065	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
488538001066	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
488538001067	active site
488538001068	Zn binding site [ion binding]; other site
488538001069	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
488538001070	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
488538001071	iron-sulfur cluster [ion binding]; other site
488538001072	[2Fe-2S] cluster binding site [ion binding]; other site
488538001073	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
488538001074	alpha subunit interface [polypeptide binding]; other site
488538001075	active site
488538001076	substrate binding site [chemical binding]; other site
488538001077	Fe binding site [ion binding]; other site
488538001078	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538001079	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
488538001080	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
488538001081	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538001082	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538001083	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
488538001084	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
488538001085	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538001086	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538001087	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
488538001088	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
488538001089	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488538001090	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538001091	TM-ABC transporter signature motif; other site
488538001092	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
488538001093	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488538001094	TM-ABC transporter signature motif; other site
488538001095	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538001096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538001097	Walker A/P-loop; other site
488538001098	ATP binding site [chemical binding]; other site
488538001099	Q-loop/lid; other site
488538001100	ABC transporter signature motif; other site
488538001101	Walker B; other site
488538001102	D-loop; other site
488538001103	H-loop/switch region; other site
488538001104	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488538001105	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488538001106	Walker A/P-loop; other site
488538001107	ATP binding site [chemical binding]; other site
488538001108	Q-loop/lid; other site
488538001109	ABC transporter signature motif; other site
488538001110	Walker B; other site
488538001111	D-loop; other site
488538001112	H-loop/switch region; other site
488538001113	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
488538001114	HlyD family secretion protein; Region: HlyD_3; pfam13437
488538001115	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
488538001116	Transglycosylase SLT domain; Region: SLT_2; pfam13406
488538001117	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
488538001118	N-acetyl-D-glucosamine binding site [chemical binding]; other site
488538001119	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
488538001120	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
488538001121	Sporulation related domain; Region: SPOR; pfam05036
488538001122	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
488538001123	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
488538001124	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
488538001125	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
488538001126	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
488538001127	TMP-binding site; other site
488538001128	ATP-binding site [chemical binding]; other site
488538001129	DNA polymerase III subunit delta'; Validated; Region: PRK07471
488538001130	DNA polymerase III subunit delta'; Validated; Region: PRK08485
488538001131	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
488538001132	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
488538001133	active site
488538001134	HIGH motif; other site
488538001135	KMSKS motif; other site
488538001136	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
488538001137	tRNA binding surface [nucleotide binding]; other site
488538001138	anticodon binding site; other site
488538001139	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
488538001140	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
488538001141	active site
488538001142	putative hydrolase; Provisional; Region: PRK02113
488538001143	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
488538001144	Peptidase family M48; Region: Peptidase_M48; cl12018
488538001145	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
488538001146	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
488538001147	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
488538001148	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
488538001149	large terminase protein; Provisional; Region: 17; PHA02533
488538001150	Terminase-like family; Region: Terminase_6; pfam03237
488538001151	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
488538001152	Phage Tail Collar Domain; Region: Collar; pfam07484
488538001153	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
488538001154	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
488538001155	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
488538001156	active site
488538001157	dimer interface [polypeptide binding]; other site
488538001158	effector binding site; other site
488538001159	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
488538001160	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
488538001161	cofactor binding site; other site
488538001162	DNA binding site [nucleotide binding]
488538001163	substrate interaction site [chemical binding]; other site
488538001164	exonuclease; Region: PHA00439
488538001165	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
488538001166	putative active site [active]
488538001167	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
488538001168	putative DNA binding site [nucleotide binding]; other site
488538001169	putative metal binding site [ion binding]; other site
488538001170	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_B; cd08643
488538001171	active site
488538001172	DNA binding site [nucleotide binding]
488538001173	catalytic site [active]
488538001174	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
488538001175	putative metal binding site [ion binding]; other site
488538001176	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl17533
488538001177	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
488538001178	active site
488538001179	metal binding site [ion binding]; metal-binding site
488538001180	interdomain interaction site; other site
488538001181	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488538001182	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
488538001183	Walker A motif; other site
488538001184	ATP binding site [chemical binding]; other site
488538001185	Walker B motif; other site
488538001186	single-stranded DNA-binding protein; Region: PHA00458
488538001187	T3/T7-like RNA polymerase; Region: PHA00452
488538001188	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
488538001189	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
488538001190	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488538001191	active site
488538001192	catalytic residues [active]
488538001193	DNA binding site [nucleotide binding]
488538001194	Int/Topo IB signature motif; other site
488538001195	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
488538001196	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
488538001197	active site
488538001198	(T/H)XGH motif; other site
488538001199	DNA gyrase subunit A; Validated; Region: PRK05560
488538001200	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
488538001201	CAP-like domain; other site
488538001202	active site
488538001203	primary dimer interface [polypeptide binding]; other site
488538001204	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488538001205	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488538001206	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488538001207	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488538001208	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488538001209	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
488538001210	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
488538001211	dimer interface [polypeptide binding]; other site
488538001212	ssDNA binding site [nucleotide binding]; other site
488538001213	tetramer (dimer of dimers) interface [polypeptide binding]; other site
488538001214	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
488538001215	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
488538001216	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
488538001217	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
488538001218	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
488538001219	Glucose inhibited division protein A; Region: GIDA; pfam01134
488538001220	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
488538001221	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
488538001222	Protein export membrane protein; Region: SecD_SecF; pfam02355
488538001223	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
488538001224	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
488538001225	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
488538001226	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
488538001227	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
488538001228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538001229	Walker A motif; other site
488538001230	ATP binding site [chemical binding]; other site
488538001231	Walker B motif; other site
488538001232	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
488538001233	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
488538001234	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
488538001235	Peptidase family M23; Region: Peptidase_M23; pfam01551
488538001236	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
488538001237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538001238	S-adenosylmethionine binding site [chemical binding]; other site
488538001239	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
488538001240	seryl-tRNA synthetase; Provisional; Region: PRK05431
488538001241	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
488538001242	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
488538001243	dimer interface [polypeptide binding]; other site
488538001244	active site
488538001245	motif 1; other site
488538001246	motif 2; other site
488538001247	motif 3; other site
488538001248	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
488538001249	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
488538001250	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
488538001251	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488538001252	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
488538001253	Walker A/P-loop; other site
488538001254	ATP binding site [chemical binding]; other site
488538001255	Q-loop/lid; other site
488538001256	ABC transporter signature motif; other site
488538001257	Walker B; other site
488538001258	D-loop; other site
488538001259	H-loop/switch region; other site
488538001260	TOBE domain; Region: TOBE_2; pfam08402
488538001261	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
488538001262	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
488538001263	Sporulation related domain; Region: SPOR; pfam05036
488538001264	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
488538001265	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
488538001266	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
488538001267	active site
488538001268	HIGH motif; other site
488538001269	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538001270	KMSK motif region; other site
488538001271	tRNA binding surface [nucleotide binding]; other site
488538001272	DALR anticodon binding domain; Region: DALR_1; smart00836
488538001273	anticodon binding site; other site
488538001274	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
488538001275	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488538001276	Zn2+ binding site [ion binding]; other site
488538001277	Mg2+ binding site [ion binding]; other site
488538001278	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
488538001279	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
488538001280	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
488538001281	putative catalytic site [active]
488538001282	putative phosphate binding site [ion binding]; other site
488538001283	active site
488538001284	metal binding site A [ion binding]; metal-binding site
488538001285	DNA binding site [nucleotide binding]
488538001286	putative AP binding site [nucleotide binding]; other site
488538001287	putative metal binding site B [ion binding]; other site
488538001288	putative acetyltransferase; Provisional; Region: PRK03624
488538001289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538001290	Coenzyme A binding pocket [chemical binding]; other site
488538001291	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
488538001292	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
488538001293	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
488538001294	HIGH motif; other site
488538001295	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
488538001296	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
488538001297	active site
488538001298	KMSKS motif; other site
488538001299	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
488538001300	tRNA binding surface [nucleotide binding]; other site
488538001301	anticodon binding site; other site
488538001302	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
488538001303	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
488538001304	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
488538001305	Methyltransferase domain; Region: Methyltransf_18; pfam12847
488538001306	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
488538001307	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
488538001308	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
488538001309	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
488538001310	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
488538001311	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
488538001312	dimerization interface [polypeptide binding]; other site
488538001313	ATP binding site [chemical binding]; other site
488538001314	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
488538001315	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
488538001316	active site residue [active]
488538001317	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
488538001318	Cupin domain; Region: Cupin_2; pfam07883
488538001319	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
488538001320	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
488538001321	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
488538001322	metal binding site [ion binding]; metal-binding site
488538001323	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
488538001324	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
488538001325	substrate binding site [chemical binding]; other site
488538001326	glutamase interaction surface [polypeptide binding]; other site
488538001327	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
488538001328	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
488538001329	catalytic residues [active]
488538001330	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
488538001331	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
488538001332	putative active site [active]
488538001333	oxyanion strand; other site
488538001334	catalytic triad [active]
488538001335	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
488538001336	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538001337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001338	homodimer interface [polypeptide binding]; other site
488538001339	catalytic residue [active]
488538001340	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
488538001341	putative active site pocket [active]
488538001342	4-fold oligomerization interface [polypeptide binding]; other site
488538001343	metal binding residues [ion binding]; metal-binding site
488538001344	3-fold/trimer interface [polypeptide binding]; other site
488538001345	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
488538001346	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
488538001347	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
488538001348	Trp repressor protein; Region: Trp_repressor; cl17266
488538001349	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488538001350	catalytic core [active]
488538001351	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
488538001352	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
488538001353	dimer interface [polypeptide binding]; other site
488538001354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001355	catalytic residue [active]
488538001356	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
488538001357	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
488538001358	active site residue [active]
488538001359	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
488538001360	active site residue [active]
488538001361	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488538001362	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488538001363	Walker A/P-loop; other site
488538001364	ATP binding site [chemical binding]; other site
488538001365	Q-loop/lid; other site
488538001366	ABC transporter signature motif; other site
488538001367	Walker B; other site
488538001368	D-loop; other site
488538001369	H-loop/switch region; other site
488538001370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001371	dimer interface [polypeptide binding]; other site
488538001372	conserved gate region; other site
488538001373	putative PBP binding loops; other site
488538001374	ABC-ATPase subunit interface; other site
488538001375	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
488538001376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001377	conserved gate region; other site
488538001378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
488538001379	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
488538001380	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488538001381	substrate binding pocket [chemical binding]; other site
488538001382	membrane-bound complex binding site; other site
488538001383	hinge residues; other site
488538001384	BCCT family transporter; Region: BCCT; pfam02028
488538001385	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
488538001386	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
488538001387	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
488538001388	NAD(P) binding site [chemical binding]; other site
488538001389	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
488538001390	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
488538001391	putative active site [active]
488538001392	Zn binding site [ion binding]; other site
488538001393	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
488538001394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538001395	Coenzyme A binding pocket [chemical binding]; other site
488538001396	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
488538001397	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
488538001398	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
488538001399	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
488538001400	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
488538001401	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
488538001402	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
488538001403	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
488538001404	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
488538001405	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
488538001406	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
488538001407	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
488538001408	potential protein location (hypothetical protein) that overlaps protein (multiple resistance and pH regulation protein F)
488538001409	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
488538001410	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
488538001411	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
488538001412	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
488538001413	trimerization site [polypeptide binding]; other site
488538001414	active site
488538001415	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
488538001416	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
488538001417	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
488538001418	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
488538001419	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
488538001420	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
488538001421	cyclase homology domain; Region: CHD; cd07302
488538001422	nucleotidyl binding site; other site
488538001423	metal binding site [ion binding]; metal-binding site
488538001424	dimer interface [polypeptide binding]; other site
488538001425	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
488538001426	nudix motif; other site
488538001427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
488538001428	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
488538001429	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538001430	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
488538001431	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538001432	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
488538001433	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
488538001434	DctM-like transporters; Region: DctM; pfam06808
488538001435	hypothetical protein; Provisional; Region: PRK07475
488538001436	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
488538001437	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
488538001438	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
488538001439	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
488538001440	DHH family; Region: DHH; pfam01368
488538001441	DHHA1 domain; Region: DHHA1; pfam02272
488538001442	homoserine dehydrogenase; Provisional; Region: PRK06349
488538001443	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
488538001444	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
488538001445	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
488538001446	5-oxoprolinase; Region: PLN02666
488538001447	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
488538001448	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
488538001449	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
488538001450	Uncharacterized conserved protein [Function unknown]; Region: COG3791
488538001451	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488538001452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538001453	Coenzyme A binding pocket [chemical binding]; other site
488538001454	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
488538001455	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488538001456	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
488538001457	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
488538001458	23S rRNA interface [nucleotide binding]; other site
488538001459	L3 interface [polypeptide binding]; other site
488538001460	Glutamine amidotransferase class-I; Region: GATase; pfam00117
488538001461	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
488538001462	glutamine binding [chemical binding]; other site
488538001463	catalytic triad [active]
488538001464	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
488538001465	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
488538001466	homodimer interface [polypeptide binding]; other site
488538001467	substrate-cofactor binding pocket; other site
488538001468	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001469	catalytic residue [active]
488538001470	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
488538001471	Sel1-like repeats; Region: SEL1; smart00671
488538001472	Sel1-like repeats; Region: SEL1; smart00671
488538001473	Sel1-like repeats; Region: SEL1; smart00671
488538001474	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
488538001475	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
488538001476	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
488538001477	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
488538001478	active site
488538001479	ribulose/triose binding site [chemical binding]; other site
488538001480	phosphate binding site [ion binding]; other site
488538001481	substrate (anthranilate) binding pocket [chemical binding]; other site
488538001482	product (indole) binding pocket [chemical binding]; other site
488538001483	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
488538001484	trimer interface [polypeptide binding]; other site
488538001485	dimer interface [polypeptide binding]; other site
488538001486	putative active site [active]
488538001487	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
488538001488	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
488538001489	dimer interface [polypeptide binding]; other site
488538001490	putative functional site; other site
488538001491	putative MPT binding site; other site
488538001492	LexA repressor; Validated; Region: PRK00215
488538001493	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
488538001494	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
488538001495	Catalytic site [active]
488538001496	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
488538001497	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
488538001498	Competence protein; Region: Competence; pfam03772
488538001499	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
488538001500	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538001501	active site
488538001502	HIGH motif; other site
488538001503	nucleotide binding site [chemical binding]; other site
488538001504	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
488538001505	active site
488538001506	KMSKS motif; other site
488538001507	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
488538001508	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
488538001509	dimer interface [polypeptide binding]; other site
488538001510	active site
488538001511	citrylCoA binding site [chemical binding]; other site
488538001512	NADH binding [chemical binding]; other site
488538001513	cationic pore residues; other site
488538001514	oxalacetate/citrate binding site [chemical binding]; other site
488538001515	coenzyme A binding site [chemical binding]; other site
488538001516	catalytic triad [active]
488538001517	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
488538001518	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
488538001519	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
488538001520	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
488538001521	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
488538001522	active site
488538001523	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
488538001524	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
488538001525	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
488538001526	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
488538001527	trimer interface [polypeptide binding]; other site
488538001528	active site
488538001529	UDP-GlcNAc binding site [chemical binding]; other site
488538001530	lipid binding site [chemical binding]; lipid-binding site
488538001531	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
488538001532	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
488538001533	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
488538001534	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
488538001535	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
488538001536	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
488538001537	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
488538001538	Surface antigen; Region: Bac_surface_Ag; pfam01103
488538001539	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
488538001540	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
488538001541	active site
488538001542	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
488538001543	protein binding site [polypeptide binding]; other site
488538001544	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
488538001545	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
488538001546	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
488538001547	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
488538001548	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
488538001549	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
488538001550	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
488538001551	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
488538001552	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
488538001553	catalytic residue [active]
488538001554	putative FPP diphosphate  binding site; other site
488538001555	putative FPP binding hydrophobic cleft; other site
488538001556	dimer interface [polypeptide binding]; other site
488538001557	putative IPP diphosphate binding site; other site
488538001558	ribosome recycling factor; Reviewed; Region: frr; PRK00083
488538001559	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
488538001560	hinge region; other site
488538001561	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
488538001562	putative nucleotide binding site [chemical binding]; other site
488538001563	uridine monophosphate binding site [chemical binding]; other site
488538001564	homohexameric interface [polypeptide binding]; other site
488538001565	elongation factor Ts; Provisional; Region: tsf; PRK09377
488538001566	UBA/TS-N domain; Region: UBA; pfam00627
488538001567	Elongation factor TS; Region: EF_TS; pfam00889
488538001568	Elongation factor TS; Region: EF_TS; pfam00889
488538001569	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
488538001570	rRNA interaction site [nucleotide binding]; other site
488538001571	S8 interaction site; other site
488538001572	putative laminin-1 binding site; other site
488538001573	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
488538001574	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
488538001575	putative active site [active]
488538001576	putative PHP Thumb interface [polypeptide binding]; other site
488538001577	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
488538001578	generic binding surface I; other site
488538001579	generic binding surface II; other site
488538001580	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488538001581	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488538001582	Walker A/P-loop; other site
488538001583	ATP binding site [chemical binding]; other site
488538001584	Q-loop/lid; other site
488538001585	ABC transporter signature motif; other site
488538001586	Walker B; other site
488538001587	D-loop; other site
488538001588	H-loop/switch region; other site
488538001589	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
488538001590	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
488538001591	FtsX-like permease family; Region: FtsX; pfam02687
488538001592	prolyl-tRNA synthetase; Provisional; Region: PRK12325
488538001593	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
488538001594	dimer interface [polypeptide binding]; other site
488538001595	motif 1; other site
488538001596	active site
488538001597	motif 2; other site
488538001598	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
488538001599	active site
488538001600	motif 3; other site
488538001601	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
488538001602	anticodon binding site; other site
488538001603	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
488538001604	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
488538001605	substrate binding site [chemical binding]; other site
488538001606	oxyanion hole (OAH) forming residues; other site
488538001607	trimer interface [polypeptide binding]; other site
488538001608	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
488538001609	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
488538001610	dimer interface [polypeptide binding]; other site
488538001611	allosteric magnesium binding site [ion binding]; other site
488538001612	active site
488538001613	aspartate-rich active site metal binding site; other site
488538001614	Schiff base residues; other site
488538001615	threonine dehydratase; Provisional; Region: PRK07334
488538001616	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
488538001617	tetramer interface [polypeptide binding]; other site
488538001618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001619	catalytic residue [active]
488538001620	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
488538001621	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
488538001622	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
488538001623	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
488538001624	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
488538001625	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
488538001626	CAP-like domain; other site
488538001627	active site
488538001628	primary dimer interface [polypeptide binding]; other site
488538001629	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
488538001630	Recombination protein O N terminal; Region: RecO_N; pfam11967
488538001631	Recombination protein O C terminal; Region: RecO_C; pfam02565
488538001632	GTPase Era; Reviewed; Region: era; PRK00089
488538001633	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
488538001634	G1 box; other site
488538001635	GTP/Mg2+ binding site [chemical binding]; other site
488538001636	Switch I region; other site
488538001637	G2 box; other site
488538001638	Switch II region; other site
488538001639	G3 box; other site
488538001640	G4 box; other site
488538001641	G5 box; other site
488538001642	KH domain; Region: KH_2; pfam07650
488538001643	ribonuclease III; Reviewed; Region: rnc; PRK00102
488538001644	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
488538001645	dimerization interface [polypeptide binding]; other site
488538001646	active site
488538001647	metal binding site [ion binding]; metal-binding site
488538001648	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
488538001649	dsRNA binding site [nucleotide binding]; other site
488538001650	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
488538001651	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
488538001652	Catalytic site [active]
488538001653	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
488538001654	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
488538001655	active site
488538001656	hydrophilic channel; other site
488538001657	dimerization interface [polypeptide binding]; other site
488538001658	catalytic residues [active]
488538001659	active site lid [active]
488538001660	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
488538001661	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
488538001662	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488538001663	Zn2+ binding site [ion binding]; other site
488538001664	Mg2+ binding site [ion binding]; other site
488538001665	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
488538001666	synthetase active site [active]
488538001667	NTP binding site [chemical binding]; other site
488538001668	metal binding site [ion binding]; metal-binding site
488538001669	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
488538001670	ACT domain; Region: ACT_4; pfam13291
488538001671	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
488538001672	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
488538001673	catalytic center binding site [active]
488538001674	ATP binding site [chemical binding]; other site
488538001675	Uncharacterized conserved protein [Function unknown]; Region: COG1432
488538001676	LabA_like proteins; Region: LabA; cd10911
488538001677	putative metal binding site [ion binding]; other site
488538001678	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
488538001679	Fe-S cluster binding site [ion binding]; other site
488538001680	DNA binding site [nucleotide binding]
488538001681	active site
488538001682	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
488538001683	SmpB-tmRNA interface; other site
488538001684	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
488538001685	dihydrodipicolinate synthase; Region: dapA; TIGR00674
488538001686	dimer interface [polypeptide binding]; other site
488538001687	active site
488538001688	catalytic residue [active]
488538001689	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
488538001690	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
488538001691	tetramer interface [polypeptide binding]; other site
488538001692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001693	catalytic residue [active]
488538001694	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538001695	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538001696	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538001697	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538001698	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538001699	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
488538001700	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
488538001701	homotrimer interface [polypeptide binding]; other site
488538001702	Walker A motif; other site
488538001703	GTP binding site [chemical binding]; other site
488538001704	Walker B motif; other site
488538001705	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
488538001706	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
488538001707	putative dimer interface [polypeptide binding]; other site
488538001708	active site pocket [active]
488538001709	putative cataytic base [active]
488538001710	cobalamin synthase; Reviewed; Region: cobS; PRK00235
488538001711	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488538001712	catalytic core [active]
488538001713	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
488538001714	30S subunit binding site; other site
488538001715	SprT-like family; Region: SprT-like; pfam10263
488538001716	SprT homologues; Region: SprT; cl01182
488538001717	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
488538001718	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538001719	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538001720	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
488538001721	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
488538001722	substrate binding site [chemical binding]; other site
488538001723	oxyanion hole (OAH) forming residues; other site
488538001724	trimer interface [polypeptide binding]; other site
488538001725	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
488538001726	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
488538001727	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
488538001728	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
488538001729	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
488538001730	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
488538001731	homodimer interface [polypeptide binding]; other site
488538001732	active site
488538001733	SAM binding site [chemical binding]; other site
488538001734	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
488538001735	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
488538001736	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
488538001737	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
488538001738	active site
488538001739	SAM binding site [chemical binding]; other site
488538001740	homodimer interface [polypeptide binding]; other site
488538001741	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
488538001742	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
488538001743	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
488538001744	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
488538001745	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
488538001746	active site
488538001747	SAM binding site [chemical binding]; other site
488538001748	homodimer interface [polypeptide binding]; other site
488538001749	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
488538001750	active site
488538001751	SAM binding site [chemical binding]; other site
488538001752	homodimer interface [polypeptide binding]; other site
488538001753	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
488538001754	active site
488538001755	putative homodimer interface [polypeptide binding]; other site
488538001756	SAM binding site [chemical binding]; other site
488538001757	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
488538001758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538001759	S-adenosylmethionine binding site [chemical binding]; other site
488538001760	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
488538001761	Precorrin-8X methylmutase; Region: CbiC; pfam02570
488538001762	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
488538001763	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
488538001764	putative active site [active]
488538001765	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
488538001766	putative active site [active]
488538001767	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
488538001768	cobyric acid synthase; Provisional; Region: PRK00784
488538001769	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
488538001770	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
488538001771	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
488538001772	catalytic triad [active]
488538001773	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
488538001774	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
488538001775	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
488538001776	homodimer interface [polypeptide binding]; other site
488538001777	Walker A motif; other site
488538001778	ATP binding site [chemical binding]; other site
488538001779	hydroxycobalamin binding site [chemical binding]; other site
488538001780	Walker B motif; other site
488538001781	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
488538001782	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
488538001783	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
488538001784	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
488538001785	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
488538001786	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
488538001787	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
488538001788	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
488538001789	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538001790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001791	homodimer interface [polypeptide binding]; other site
488538001792	catalytic residue [active]
488538001793	L-asparaginase II; Region: Asparaginase_II; pfam06089
488538001794	hypothetical protein; Provisional; Region: PRK06148
488538001795	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
488538001796	active site
488538001797	ATP binding site [chemical binding]; other site
488538001798	substrate binding site [chemical binding]; other site
488538001799	Peptidase family M23; Region: Peptidase_M23; pfam01551
488538001800	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
488538001801	inhibitor-cofactor binding pocket; inhibition site
488538001802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538001803	catalytic residue [active]
488538001804	short chain dehydrogenase; Provisional; Region: PRK07024
488538001805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538001806	NAD(P) binding site [chemical binding]; other site
488538001807	active site
488538001808	SnoaL-like domain; Region: SnoaL_2; pfam12680
488538001809	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
488538001810	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
488538001811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538001812	S-adenosylmethionine binding site [chemical binding]; other site
488538001813	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
488538001814	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
488538001815	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
488538001816	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
488538001817	active site
488538001818	catalytic residues [active]
488538001819	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
488538001820	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
488538001821	active site
488538001822	catalytic tetrad [active]
488538001823	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
488538001824	Protein of unknown function (DUF952); Region: DUF952; cl01393
488538001825	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
488538001826	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538001827	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538001828	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
488538001829	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
488538001830	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
488538001831	active site
488538001832	Fe binding site [ion binding]; other site
488538001833	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
488538001834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001835	dimer interface [polypeptide binding]; other site
488538001836	conserved gate region; other site
488538001837	putative PBP binding loops; other site
488538001838	ABC-ATPase subunit interface; other site
488538001839	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
488538001840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538001841	Walker A/P-loop; other site
488538001842	ATP binding site [chemical binding]; other site
488538001843	Q-loop/lid; other site
488538001844	ABC transporter signature motif; other site
488538001845	Walker B; other site
488538001846	D-loop; other site
488538001847	H-loop/switch region; other site
488538001848	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
488538001849	PBP superfamily domain; Region: PBP_like_2; pfam12849
488538001850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538001851	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538001852	putative substrate translocation pore; other site
488538001853	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538001854	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
488538001855	Fatty acid desaturase; Region: FA_desaturase; pfam00487
488538001856	putative di-iron ligands [ion binding]; other site
488538001857	hypothetical protein; Validated; Region: PRK02101
488538001858	allantoate amidohydrolase; Reviewed; Region: PRK12893
488538001859	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
488538001860	active site
488538001861	metal binding site [ion binding]; metal-binding site
488538001862	dimer interface [polypeptide binding]; other site
488538001863	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
488538001864	Amidase; Region: Amidase; cl11426
488538001865	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
488538001866	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538001867	Walker A/P-loop; other site
488538001868	ATP binding site [chemical binding]; other site
488538001869	Q-loop/lid; other site
488538001870	ABC transporter signature motif; other site
488538001871	Walker B; other site
488538001872	D-loop; other site
488538001873	H-loop/switch region; other site
488538001874	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
488538001875	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538001876	Walker A/P-loop; other site
488538001877	ATP binding site [chemical binding]; other site
488538001878	Q-loop/lid; other site
488538001879	ABC transporter signature motif; other site
488538001880	Walker B; other site
488538001881	D-loop; other site
488538001882	H-loop/switch region; other site
488538001883	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488538001884	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
488538001885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001886	dimer interface [polypeptide binding]; other site
488538001887	conserved gate region; other site
488538001888	putative PBP binding loops; other site
488538001889	ABC-ATPase subunit interface; other site
488538001890	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
488538001891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538001892	dimer interface [polypeptide binding]; other site
488538001893	conserved gate region; other site
488538001894	putative PBP binding loops; other site
488538001895	ABC-ATPase subunit interface; other site
488538001896	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
488538001897	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
488538001898	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
488538001899	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
488538001900	active site
488538001901	catalytic tetrad [active]
488538001902	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
488538001903	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
488538001904	ligand binding site [chemical binding]; other site
488538001905	flexible hinge region; other site
488538001906	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
488538001907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538001908	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
488538001909	Walker A/P-loop; other site
488538001910	ATP binding site [chemical binding]; other site
488538001911	Q-loop/lid; other site
488538001912	ABC transporter signature motif; other site
488538001913	Walker B; other site
488538001914	D-loop; other site
488538001915	H-loop/switch region; other site
488538001916	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
488538001917	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
488538001918	GatB domain; Region: GatB_Yqey; smart00845
488538001919	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
488538001920	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
488538001921	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
488538001922	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
488538001923	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
488538001924	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
488538001925	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
488538001926	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
488538001927	dihydroorotase; Validated; Region: pyrC; PRK09357
488538001928	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
488538001929	active site
488538001930	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
488538001931	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
488538001932	DNA protecting protein DprA; Region: dprA; TIGR00732
488538001933	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
488538001934	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
488538001935	active site
488538001936	interdomain interaction site; other site
488538001937	putative metal-binding site [ion binding]; other site
488538001938	nucleotide binding site [chemical binding]; other site
488538001939	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
488538001940	domain I; other site
488538001941	DNA binding groove [nucleotide binding]
488538001942	phosphate binding site [ion binding]; other site
488538001943	domain II; other site
488538001944	domain III; other site
488538001945	nucleotide binding site [chemical binding]; other site
488538001946	catalytic site [active]
488538001947	domain IV; other site
488538001948	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
488538001949	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
488538001950	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
488538001951	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
488538001952	ribonuclease R; Region: RNase_R; TIGR02063
488538001953	RNB domain; Region: RNB; pfam00773
488538001954	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
488538001955	RNA binding site [nucleotide binding]; other site
488538001956	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
488538001957	fructokinase; Reviewed; Region: PRK09557
488538001958	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
488538001959	nucleotide binding site [chemical binding]; other site
488538001960	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
488538001961	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
488538001962	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
488538001963	catalytic site [active]
488538001964	putative active site [active]
488538001965	putative substrate binding site [chemical binding]; other site
488538001966	HRDC domain; Region: HRDC; pfam00570
488538001967	short chain dehydrogenase; Provisional; Region: PRK08339
488538001968	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
488538001969	putative NAD(P) binding site [chemical binding]; other site
488538001970	putative active site [active]
488538001971	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
488538001972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
488538001973	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
488538001974	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
488538001975	dimerization interface [polypeptide binding]; other site
488538001976	putative ATP binding site [chemical binding]; other site
488538001977	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
488538001978	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
488538001979	active site
488538001980	substrate binding site [chemical binding]; other site
488538001981	cosubstrate binding site; other site
488538001982	catalytic site [active]
488538001983	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
488538001984	active site
488538001985	multimer interface [polypeptide binding]; other site
488538001986	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
488538001987	multifunctional aminopeptidase A; Provisional; Region: PRK00913
488538001988	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
488538001989	interface (dimer of trimers) [polypeptide binding]; other site
488538001990	Substrate-binding/catalytic site; other site
488538001991	Zn-binding sites [ion binding]; other site
488538001992	Predicted permeases [General function prediction only]; Region: COG0795
488538001993	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
488538001994	Predicted permeases [General function prediction only]; Region: COG0795
488538001995	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
488538001996	SurA N-terminal domain; Region: SurA_N_3; cl07813
488538001997	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
488538001998	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
488538001999	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
488538002000	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
488538002001	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
488538002002	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
488538002003	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
488538002004	catalytic site [active]
488538002005	G-X2-G-X-G-K; other site
488538002006	YceG-like family; Region: YceG; pfam02618
488538002007	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
488538002008	dimerization interface [polypeptide binding]; other site
488538002009	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
488538002010	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
488538002011	dimer interface [polypeptide binding]; other site
488538002012	active site
488538002013	acyl carrier protein; Provisional; Region: acpP; PRK00982
488538002014	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
488538002015	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538002016	NAD(P) binding site [chemical binding]; other site
488538002017	active site
488538002018	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
488538002019	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
488538002020	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
488538002021	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
488538002022	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
488538002023	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
488538002024	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
488538002025	replicative DNA helicase; Provisional; Region: PRK09165
488538002026	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
488538002027	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
488538002028	Walker A motif; other site
488538002029	ATP binding site [chemical binding]; other site
488538002030	Walker B motif; other site
488538002031	DNA binding loops [nucleotide binding]
488538002032	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
488538002033	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
488538002034	active site
488538002035	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488538002036	dimer interface [polypeptide binding]; other site
488538002037	substrate binding site [chemical binding]; other site
488538002038	catalytic residues [active]
488538002039	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
488538002040	Permease; Region: Permease; pfam02405
488538002041	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
488538002042	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
488538002043	Walker A/P-loop; other site
488538002044	ATP binding site [chemical binding]; other site
488538002045	Q-loop/lid; other site
488538002046	ABC transporter signature motif; other site
488538002047	Walker B; other site
488538002048	D-loop; other site
488538002049	H-loop/switch region; other site
488538002050	DNA repair protein RadA; Provisional; Region: PRK11823
488538002051	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
488538002052	Walker A motif/ATP binding site; other site
488538002053	ATP binding site [chemical binding]; other site
488538002054	Walker B motif; other site
488538002055	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
488538002056	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
488538002057	Colicin V production protein; Region: Colicin_V; pfam02674
488538002058	amidophosphoribosyltransferase; Provisional; Region: PRK09123
488538002059	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
488538002060	active site
488538002061	tetramer interface [polypeptide binding]; other site
488538002062	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538002063	active site
488538002064	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
488538002065	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538002066	NAD(P) binding site [chemical binding]; other site
488538002067	active site
488538002068	Methyltransferase domain; Region: Methyltransf_26; pfam13659
488538002069	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
488538002070	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
488538002071	Uncharacterized conserved protein [Function unknown]; Region: COG4121
488538002072	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
488538002073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538002074	S-adenosylmethionine binding site [chemical binding]; other site
488538002075	hypothetical protein; Provisional; Region: PRK05170
488538002076	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
488538002077	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
488538002078	C-terminal domain interface [polypeptide binding]; other site
488538002079	GSH binding site (G-site) [chemical binding]; other site
488538002080	dimer interface [polypeptide binding]; other site
488538002081	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
488538002082	putative dimer interface [polypeptide binding]; other site
488538002083	N-terminal domain interface [polypeptide binding]; other site
488538002084	active site
488538002085	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
488538002086	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
488538002087	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
488538002088	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
488538002089	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
488538002090	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
488538002091	putative MPT binding site; other site
488538002092	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
488538002093	active site
488538002094	hypothetical protein; Reviewed; Region: PRK00024
488538002095	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
488538002096	MPN+ (JAMM) motif; other site
488538002097	Zinc-binding site [ion binding]; other site
488538002098	adenylosuccinate lyase; Provisional; Region: PRK07492
488538002099	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
488538002100	tetramer interface [polypeptide binding]; other site
488538002101	active site
488538002102	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
488538002103	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
488538002104	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
488538002105	ATP binding site [chemical binding]; other site
488538002106	active site
488538002107	substrate binding site [chemical binding]; other site
488538002108	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
488538002109	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
488538002110	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
488538002111	putative active site [active]
488538002112	catalytic triad [active]
488538002113	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
488538002114	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
488538002115	dimerization interface [polypeptide binding]; other site
488538002116	ATP binding site [chemical binding]; other site
488538002117	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
488538002118	dimerization interface [polypeptide binding]; other site
488538002119	ATP binding site [chemical binding]; other site
488538002120	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
488538002121	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
488538002122	putative GSH binding site [chemical binding]; other site
488538002123	catalytic residues [active]
488538002124	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
488538002125	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
488538002126	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
488538002127	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538002128	RNA binding surface [nucleotide binding]; other site
488538002129	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
488538002130	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
488538002131	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
488538002132	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
488538002133	active site
488538002134	catalytic residues [active]
488538002135	metal binding site [ion binding]; metal-binding site
488538002136	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
488538002137	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
488538002138	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538002139	active site
488538002140	HIGH motif; other site
488538002141	nucleotide binding site [chemical binding]; other site
488538002142	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
488538002143	KMSKS motif; other site
488538002144	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
488538002145	tRNA binding surface [nucleotide binding]; other site
488538002146	anticodon binding site; other site
488538002147	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
488538002148	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
488538002149	active site
488538002150	HIGH motif; other site
488538002151	KMSKS motif; other site
488538002152	NAD synthetase; Provisional; Region: PRK13981
488538002153	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
488538002154	multimer interface [polypeptide binding]; other site
488538002155	active site
488538002156	catalytic triad [active]
488538002157	protein interface 1 [polypeptide binding]; other site
488538002158	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
488538002159	homodimer interface [polypeptide binding]; other site
488538002160	NAD binding pocket [chemical binding]; other site
488538002161	ATP binding pocket [chemical binding]; other site
488538002162	Mg binding site [ion binding]; other site
488538002163	active-site loop [active]
488538002164	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
488538002165	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
488538002166	active site
488538002167	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
488538002168	glutathione reductase; Validated; Region: PRK06116
488538002169	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538002170	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488538002171	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
488538002172	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
488538002173	acyl-activating enzyme (AAE) consensus motif; other site
488538002174	putative AMP binding site [chemical binding]; other site
488538002175	putative active site [active]
488538002176	putative CoA binding site [chemical binding]; other site
488538002177	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538002178	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
488538002179	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
488538002180	endonuclease III; Region: ENDO3c; smart00478
488538002181	minor groove reading motif; other site
488538002182	helix-hairpin-helix signature motif; other site
488538002183	substrate binding pocket [chemical binding]; other site
488538002184	active site
488538002185	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
488538002186	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
488538002187	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
488538002188	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
488538002189	FAD binding domain; Region: FAD_binding_4; pfam01565
488538002190	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
488538002191	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
488538002192	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
488538002193	putative active site [active]
488538002194	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538002195	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
488538002196	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
488538002197	OstA-like protein; Region: OstA; cl00844
488538002198	Organic solvent tolerance protein; Region: OstA_C; pfam04453
488538002199	putative acetyltransferase; Provisional; Region: PRK03624
488538002200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538002201	Coenzyme A binding pocket [chemical binding]; other site
488538002202	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
488538002203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538002204	Coenzyme A binding pocket [chemical binding]; other site
488538002205	Protein of unknown function (DUF805); Region: DUF805; pfam05656
488538002206	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
488538002207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538002208	Coenzyme A binding pocket [chemical binding]; other site
488538002209	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
488538002210	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
488538002211	glutaminase active site [active]
488538002212	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
488538002213	dimer interface [polypeptide binding]; other site
488538002214	active site
488538002215	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
488538002216	dimer interface [polypeptide binding]; other site
488538002217	active site
488538002218	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
488538002219	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
488538002220	Substrate binding site; other site
488538002221	Mg++ binding site; other site
488538002222	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
488538002223	active site
488538002224	substrate binding site [chemical binding]; other site
488538002225	CoA binding site [chemical binding]; other site
488538002226	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
488538002227	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
488538002228	putative ribose interaction site [chemical binding]; other site
488538002229	putative ADP binding site [chemical binding]; other site
488538002230	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
488538002231	active site
488538002232	nucleotide binding site [chemical binding]; other site
488538002233	HIGH motif; other site
488538002234	KMSKS motif; other site
488538002235	microcin B17 transporter; Reviewed; Region: PRK11098
488538002236	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
488538002237	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
488538002238	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
488538002239	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
488538002240	rod shape-determining protein MreC; Provisional; Region: PRK13922
488538002241	rod shape-determining protein MreC; Region: MreC; pfam04085
488538002242	rod shape-determining protein MreB; Provisional; Region: PRK13927
488538002243	MreB and similar proteins; Region: MreB_like; cd10225
488538002244	nucleotide binding site [chemical binding]; other site
488538002245	Mg binding site [ion binding]; other site
488538002246	putative protofilament interaction site [polypeptide binding]; other site
488538002247	RodZ interaction site [polypeptide binding]; other site
488538002248	ketol-acid reductoisomerase; Provisional; Region: PRK05479
488538002249	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
488538002250	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
488538002251	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
488538002252	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
488538002253	putative valine binding site [chemical binding]; other site
488538002254	dimer interface [polypeptide binding]; other site
488538002255	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
488538002256	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
488538002257	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538002258	PYR/PP interface [polypeptide binding]; other site
488538002259	dimer interface [polypeptide binding]; other site
488538002260	TPP binding site [chemical binding]; other site
488538002261	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538002262	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
488538002263	TPP-binding site [chemical binding]; other site
488538002264	dimer interface [polypeptide binding]; other site
488538002265	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
488538002266	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
488538002267	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
488538002268	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
488538002269	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
488538002270	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
488538002271	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
488538002272	protein binding site [polypeptide binding]; other site
488538002273	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
488538002274	protein binding site [polypeptide binding]; other site
488538002275	HflC protein; Region: hflC; TIGR01932
488538002276	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
488538002277	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
488538002278	HflK protein; Region: hflK; TIGR01933
488538002279	Domain of unknown function DUF59; Region: DUF59; pfam01883
488538002280	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
488538002281	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
488538002282	Walker A motif; other site
488538002283	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
488538002284	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
488538002285	folate binding site [chemical binding]; other site
488538002286	NADP+ binding site [chemical binding]; other site
488538002287	thymidylate synthase; Reviewed; Region: thyA; PRK01827
488538002288	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
488538002289	dimerization interface [polypeptide binding]; other site
488538002290	active site
488538002291	Stringent starvation protein B; Region: SspB; pfam04386
488538002292	fumarate hydratase; Provisional; Region: PRK15389
488538002293	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
488538002294	Fumarase C-terminus; Region: Fumerase_C; pfam05683
488538002295	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
488538002296	Cysteine-rich domain; Region: CCG; pfam02754
488538002297	Cysteine-rich domain; Region: CCG; pfam02754
488538002298	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
488538002299	FAD binding domain; Region: FAD_binding_4; pfam01565
488538002300	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
488538002301	FAD binding domain; Region: FAD_binding_4; pfam01565
488538002302	methionine sulfoxide reductase A; Provisional; Region: PRK00058
488538002303	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
488538002304	Phosphoglycerate kinase; Region: PGK; pfam00162
488538002305	substrate binding site [chemical binding]; other site
488538002306	hinge regions; other site
488538002307	ADP binding site [chemical binding]; other site
488538002308	catalytic site [active]
488538002309	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
488538002310	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
488538002311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
488538002312	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
488538002313	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
488538002314	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
488538002315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538002316	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538002317	putative substrate translocation pore; other site
488538002318	Amino acid synthesis; Region: AA_synth; pfam06684
488538002319	pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823
488538002320	aromatic arch; other site
488538002321	DCoH dimer interaction site [polypeptide binding]; other site
488538002322	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
488538002323	DCoH tetramer interaction site [polypeptide binding]; other site
488538002324	substrate binding site [chemical binding]; other site
488538002325	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
488538002326	Protein of unknown function (DUF461); Region: DUF461; pfam04314
488538002327	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488538002328	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
488538002329	phosphate binding site [ion binding]; other site
488538002330	Cytochrome c2 [Energy production and conversion]; Region: COG3474
488538002331	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
488538002332	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
488538002333	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
488538002334	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
488538002335	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
488538002336	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
488538002337	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538002338	EamA-like transporter family; Region: EamA; pfam00892
488538002339	Uncharacterized conserved protein [Function unknown]; Region: COG3791
488538002340	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
488538002341	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538002342	NAD(P) binding site [chemical binding]; other site
488538002343	catalytic residues [active]
488538002344	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
488538002345	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
488538002346	active site
488538002347	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
488538002348	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
488538002349	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538002350	NAD binding site [chemical binding]; other site
488538002351	catalytic residues [active]
488538002352	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538002353	EamA-like transporter family; Region: EamA; pfam00892
488538002354	EamA-like transporter family; Region: EamA; pfam00892
488538002355	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
488538002356	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
488538002357	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
488538002358	Ligand Binding Site [chemical binding]; other site
488538002359	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488538002360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002361	dimer interface [polypeptide binding]; other site
488538002362	conserved gate region; other site
488538002363	putative PBP binding loops; other site
488538002364	ABC-ATPase subunit interface; other site
488538002365	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
488538002366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002367	dimer interface [polypeptide binding]; other site
488538002368	conserved gate region; other site
488538002369	putative PBP binding loops; other site
488538002370	ABC-ATPase subunit interface; other site
488538002371	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
488538002372	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488538002373	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488538002374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538002375	Walker A/P-loop; other site
488538002376	ATP binding site [chemical binding]; other site
488538002377	Q-loop/lid; other site
488538002378	ABC transporter signature motif; other site
488538002379	Walker B; other site
488538002380	D-loop; other site
488538002381	H-loop/switch region; other site
488538002382	TOBE domain; Region: TOBE_2; pfam08402
488538002383	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488538002384	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488538002385	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
488538002386	active site
488538002387	Uncharacterized conserved protein [Function unknown]; Region: COG1479
488538002388	Protein of unknown function DUF262; Region: DUF262; pfam03235
488538002389	Protein of unknown function DUF262; Region: DUF262; pfam03235
488538002390	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
488538002391	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
488538002392	Active Sites [active]
488538002393	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488538002394	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488538002395	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
488538002396	active site
488538002397	agmatinase; Region: agmatinase; TIGR01230
488538002398	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
488538002399	oligomer interface [polypeptide binding]; other site
488538002400	active site
488538002401	Mn binding site [ion binding]; other site
488538002402	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
488538002403	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
488538002404	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
488538002405	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538002406	catalytic residue [active]
488538002407	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488538002408	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488538002409	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
488538002410	active site
488538002411	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
488538002412	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
488538002413	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488538002414	phosphate binding site [ion binding]; other site
488538002415	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
488538002416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002417	dimer interface [polypeptide binding]; other site
488538002418	conserved gate region; other site
488538002419	putative PBP binding loops; other site
488538002420	ABC-ATPase subunit interface; other site
488538002421	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
488538002422	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538002423	EamA-like transporter family; Region: EamA; pfam00892
488538002424	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
488538002425	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538002426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538002427	homodimer interface [polypeptide binding]; other site
488538002428	catalytic residue [active]
488538002429	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
488538002430	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
488538002431	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538002432	catalytic residue [active]
488538002433	thiamine pyrophosphate protein; Validated; Region: PRK08199
488538002434	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538002435	PYR/PP interface [polypeptide binding]; other site
488538002436	dimer interface [polypeptide binding]; other site
488538002437	TPP binding site [chemical binding]; other site
488538002438	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538002439	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
488538002440	TPP-binding site [chemical binding]; other site
488538002441	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
488538002442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538002443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538002444	homodimer interface [polypeptide binding]; other site
488538002445	catalytic residue [active]
488538002446	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
488538002447	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488538002448	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
488538002449	TM-ABC transporter signature motif; other site
488538002450	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538002451	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488538002452	TM-ABC transporter signature motif; other site
488538002453	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488538002454	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488538002455	Walker A/P-loop; other site
488538002456	ATP binding site [chemical binding]; other site
488538002457	Q-loop/lid; other site
488538002458	ABC transporter signature motif; other site
488538002459	Walker B; other site
488538002460	D-loop; other site
488538002461	H-loop/switch region; other site
488538002462	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538002463	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
488538002464	Walker A/P-loop; other site
488538002465	ATP binding site [chemical binding]; other site
488538002466	Q-loop/lid; other site
488538002467	ABC transporter signature motif; other site
488538002468	Walker B; other site
488538002469	D-loop; other site
488538002470	H-loop/switch region; other site
488538002471	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
488538002472	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
488538002473	putative ligand binding site [chemical binding]; other site
488538002474	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
488538002475	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538002476	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
488538002477	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
488538002478	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
488538002479	acyl-activating enzyme (AAE) consensus motif; other site
488538002480	AMP binding site [chemical binding]; other site
488538002481	active site
488538002482	CoA binding site [chemical binding]; other site
488538002483	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
488538002484	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
488538002485	Na binding site [ion binding]; other site
488538002486	putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647
488538002487	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
488538002488	Beta-lactamase; Region: Beta-lactamase; pfam00144
488538002489	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
488538002490	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
488538002491	homodimer interface [polypeptide binding]; other site
488538002492	substrate-cofactor binding pocket; other site
488538002493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538002494	catalytic residue [active]
488538002495	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
488538002496	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
488538002497	HflX GTPase family; Region: HflX; cd01878
488538002498	G1 box; other site
488538002499	GTP/Mg2+ binding site [chemical binding]; other site
488538002500	Switch I region; other site
488538002501	G2 box; other site
488538002502	G3 box; other site
488538002503	Switch II region; other site
488538002504	G4 box; other site
488538002505	G5 box; other site
488538002506	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
488538002507	classical (c) SDRs; Region: SDR_c; cd05233
488538002508	NAD(P) binding site [chemical binding]; other site
488538002509	active site
488538002510	DNA photolyase; Region: DNA_photolyase; pfam00875
488538002511	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
488538002512	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
488538002513	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
488538002514	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
488538002515	NAD(P) binding site [chemical binding]; other site
488538002516	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
488538002517	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
488538002518	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
488538002519	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
488538002520	Peptidase family M23; Region: Peptidase_M23; pfam01551
488538002521	Ion channel; Region: Ion_trans_2; pfam07885
488538002522	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
488538002523	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
488538002524	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
488538002525	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
488538002526	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
488538002527	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
488538002528	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
488538002529	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
488538002530	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
488538002531	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
488538002532	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
488538002533	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
488538002534	ligand binding site [chemical binding]; other site
488538002535	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
488538002536	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
488538002537	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
488538002538	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
488538002539	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
488538002540	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
488538002541	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
488538002542	flagellar motor switch protein FliN; Region: fliN; TIGR02480
488538002543	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
488538002544	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
488538002545	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
488538002546	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
488538002547	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
488538002548	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
488538002549	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488538002550	Walker A motif; other site
488538002551	ATP binding site [chemical binding]; other site
488538002552	Walker B motif; other site
488538002553	Flagellar assembly protein FliH; Region: FliH; pfam02108
488538002554	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
488538002555	FliG C-terminal domain; Region: FliG_C; pfam01706
488538002556	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
488538002557	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
488538002558	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
488538002559	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
488538002560	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
488538002561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538002562	Walker A motif; other site
488538002563	ATP binding site [chemical binding]; other site
488538002564	Walker B motif; other site
488538002565	arginine finger; other site
488538002566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538002567	Walker A motif; other site
488538002568	ATP binding site [chemical binding]; other site
488538002569	Walker B motif; other site
488538002570	arginine finger; other site
488538002571	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
488538002572	Flagellar protein FliS; Region: FliS; cl00654
488538002573	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
488538002574	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
488538002575	Cl- selectivity filter; other site
488538002576	Cl- binding residues [ion binding]; other site
488538002577	pore gating glutamate residue; other site
488538002578	dimer interface [polypeptide binding]; other site
488538002579	FOG: CBS domain [General function prediction only]; Region: COG0517
488538002580	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
488538002581	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
488538002582	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
488538002583	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
488538002584	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
488538002585	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
488538002586	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
488538002587	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
488538002588	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
488538002589	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
488538002590	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
488538002591	Rod binding protein; Region: Rod-binding; cl01626
488538002592	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
488538002593	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
488538002594	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
488538002595	Flagellar L-ring protein; Region: FlgH; pfam02107
488538002596	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
488538002597	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
488538002598	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
488538002599	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
488538002600	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
488538002601	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
488538002602	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
488538002603	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
488538002604	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
488538002605	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
488538002606	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
488538002607	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
488538002608	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
488538002609	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
488538002610	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
488538002611	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
488538002612	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
488538002613	SAF-like; Region: SAF_2; pfam13144
488538002614	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
488538002615	FimV N-terminal domain; Region: FimV_core; TIGR03505
488538002616	LPP20 lipoprotein; Region: LPP20; pfam02169
488538002617	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
488538002618	FHIPEP family; Region: FHIPEP; pfam00771
488538002619	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
488538002620	AAA domain; Region: AAA_17; pfam13207
488538002621	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
488538002622	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
488538002623	P-loop; other site
488538002624	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
488538002625	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
488538002626	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
488538002627	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
488538002628	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
488538002629	DNA binding residues [nucleotide binding]
488538002630	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
488538002631	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
488538002632	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
488538002633	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
488538002634	Sel1-like repeats; Region: SEL1; smart00671
488538002635	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
488538002636	Sensors of blue-light using FAD; Region: BLUF; pfam04940
488538002637	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
488538002638	CoA-transferase family III; Region: CoA_transf_3; pfam02515
488538002639	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
488538002640	Uncharacterized conserved protein [Function unknown]; Region: COG3777
488538002641	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
488538002642	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
488538002643	active site 2 [active]
488538002644	active site 1 [active]
488538002645	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
488538002646	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
488538002647	active site
488538002648	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
488538002649	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
488538002650	Sulfate transporter family; Region: Sulfate_transp; pfam00916
488538002651	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
488538002652	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
488538002653	active site
488538002654	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488538002655	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488538002656	Coenzyme A binding pocket [chemical binding]; other site
488538002657	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
488538002658	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
488538002659	Penicillinase repressor; Region: Pencillinase_R; pfam03965
488538002660	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
488538002661	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
488538002662	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
488538002663	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
488538002664	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
488538002665	N- and C-terminal domain interface [polypeptide binding]; other site
488538002666	active site
488538002667	MgATP binding site [chemical binding]; other site
488538002668	catalytic site [active]
488538002669	metal binding site [ion binding]; metal-binding site
488538002670	glycerol binding site [chemical binding]; other site
488538002671	homotetramer interface [polypeptide binding]; other site
488538002672	homodimer interface [polypeptide binding]; other site
488538002673	FBP binding site [chemical binding]; other site
488538002674	protein IIAGlc interface [polypeptide binding]; other site
488538002675	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
488538002676	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488538002677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002678	dimer interface [polypeptide binding]; other site
488538002679	conserved gate region; other site
488538002680	ABC-ATPase subunit interface; other site
488538002681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002682	dimer interface [polypeptide binding]; other site
488538002683	conserved gate region; other site
488538002684	putative PBP binding loops; other site
488538002685	ABC-ATPase subunit interface; other site
488538002686	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
488538002687	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
488538002688	Walker A/P-loop; other site
488538002689	ATP binding site [chemical binding]; other site
488538002690	Q-loop/lid; other site
488538002691	ABC transporter signature motif; other site
488538002692	Walker B; other site
488538002693	D-loop; other site
488538002694	H-loop/switch region; other site
488538002695	TOBE domain; Region: TOBE_2; pfam08402
488538002696	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
488538002697	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
488538002698	Walker A/P-loop; other site
488538002699	ATP binding site [chemical binding]; other site
488538002700	Q-loop/lid; other site
488538002701	ABC transporter signature motif; other site
488538002702	Walker B; other site
488538002703	D-loop; other site
488538002704	H-loop/switch region; other site
488538002705	TOBE domain; Region: TOBE_2; pfam08402
488538002706	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488538002707	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488538002708	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
488538002709	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
488538002710	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
488538002711	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
488538002712	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
488538002713	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
488538002714	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
488538002715	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488538002716	Walker A/P-loop; other site
488538002717	ATP binding site [chemical binding]; other site
488538002718	Q-loop/lid; other site
488538002719	ABC transporter signature motif; other site
488538002720	Walker B; other site
488538002721	D-loop; other site
488538002722	H-loop/switch region; other site
488538002723	ABC-2 type transporter; Region: ABC2_membrane; cl17235
488538002724	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
488538002725	Transcriptional regulator; Region: Rrf2; cl17282
488538002726	Rrf2 family protein; Region: rrf2_super; TIGR00738
488538002727	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
488538002728	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
488538002729	FAD binding pocket [chemical binding]; other site
488538002730	FAD binding motif [chemical binding]; other site
488538002731	phosphate binding motif [ion binding]; other site
488538002732	beta-alpha-beta structure motif; other site
488538002733	NAD binding pocket [chemical binding]; other site
488538002734	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
488538002735	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
488538002736	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
488538002737	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
488538002738	glucuronate isomerase; Reviewed; Region: PRK02925
488538002739	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
488538002740	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
488538002741	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
488538002742	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
488538002743	mannonate dehydratase; Provisional; Region: PRK03906
488538002744	mannonate dehydratase; Region: uxuA; TIGR00695
488538002745	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538002746	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
488538002747	substrate binding site [chemical binding]; other site
488538002748	ATP binding site [chemical binding]; other site
488538002749	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
488538002750	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
488538002751	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
488538002752	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
488538002753	putative ligand binding site [chemical binding]; other site
488538002754	NAD binding site [chemical binding]; other site
488538002755	catalytic site [active]
488538002756	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
488538002757	AAA domain; Region: AAA_33; pfam13671
488538002758	ATP-binding site [chemical binding]; other site
488538002759	Gluconate-6-phosphate binding site [chemical binding]; other site
488538002760	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
488538002761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002762	dimer interface [polypeptide binding]; other site
488538002763	putative PBP binding loops; other site
488538002764	ABC-ATPase subunit interface; other site
488538002765	hypothetical protein; Provisional; Region: PRK11622
488538002766	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
488538002767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538002768	Walker A/P-loop; other site
488538002769	ATP binding site [chemical binding]; other site
488538002770	ABC transporter; Region: ABC_tran; pfam00005
488538002771	Q-loop/lid; other site
488538002772	ABC transporter signature motif; other site
488538002773	Walker B; other site
488538002774	D-loop; other site
488538002775	H-loop/switch region; other site
488538002776	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
488538002777	hypothetical protein; Provisional; Region: PRK07483
488538002778	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
488538002779	inhibitor-cofactor binding pocket; inhibition site
488538002780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538002781	catalytic residue [active]
488538002782	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
488538002783	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
488538002784	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
488538002785	putative active site [active]
488538002786	enoyl-CoA hydratase; Validated; Region: PRK08139
488538002787	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
488538002788	substrate binding site [chemical binding]; other site
488538002789	oxyanion hole (OAH) forming residues; other site
488538002790	trimer interface [polypeptide binding]; other site
488538002791	putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486
488538002792	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538002793	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
488538002794	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488538002795	DNA binding site [nucleotide binding]
488538002796	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
488538002797	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
488538002798	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
488538002799	Dehydroquinase class II; Region: DHquinase_II; pfam01220
488538002800	trimer interface [polypeptide binding]; other site
488538002801	active site
488538002802	dimer interface [polypeptide binding]; other site
488538002803	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
488538002804	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
488538002805	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
488538002806	short chain dehydrogenase; Provisional; Region: PRK06125
488538002807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538002808	NAD(P) binding site [chemical binding]; other site
488538002809	active site
488538002810	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
488538002811	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
488538002812	active site
488538002813	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
488538002814	Coenzyme A transferase; Region: CoA_trans; smart00882
488538002815	Coenzyme A transferase; Region: CoA_trans; cl17247
488538002816	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538002817	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538002818	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
488538002819	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
488538002820	active site 2 [active]
488538002821	active site 1 [active]
488538002822	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
488538002823	classical (c) SDRs; Region: SDR_c; cd05233
488538002824	NAD(P) binding site [chemical binding]; other site
488538002825	active site
488538002826	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
488538002827	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488538002828	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488538002829	Walker A/P-loop; other site
488538002830	ATP binding site [chemical binding]; other site
488538002831	Q-loop/lid; other site
488538002832	ABC transporter signature motif; other site
488538002833	Walker B; other site
488538002834	D-loop; other site
488538002835	H-loop/switch region; other site
488538002836	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538002837	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488538002838	TM-ABC transporter signature motif; other site
488538002839	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
488538002840	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
488538002841	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
488538002842	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488538002843	TM-ABC transporter signature motif; other site
488538002844	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538002845	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
488538002846	Walker A/P-loop; other site
488538002847	ATP binding site [chemical binding]; other site
488538002848	Q-loop/lid; other site
488538002849	ABC transporter signature motif; other site
488538002850	Walker B; other site
488538002851	D-loop; other site
488538002852	H-loop/switch region; other site
488538002853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538002854	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538002855	putative substrate translocation pore; other site
488538002856	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538002857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538002858	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
488538002859	putative effector binding pocket; other site
488538002860	dimerization interface [polypeptide binding]; other site
488538002861	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
488538002862	tetramer interface [polypeptide binding]; other site
488538002863	dimer interface [polypeptide binding]; other site
488538002864	active site
488538002865	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
488538002866	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
488538002867	active site
488538002868	Fe(II) binding site [ion binding]; other site
488538002869	dimer interface [polypeptide binding]; other site
488538002870	tetramer interface [polypeptide binding]; other site
488538002871	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538002872	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538002873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
488538002874	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
488538002875	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
488538002876	active site
488538002877	Amidohydrolase; Region: Amidohydro_2; pfam04909
488538002878	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
488538002879	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
488538002880	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
488538002881	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
488538002882	active site
488538002883	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
488538002884	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538002885	Walker A/P-loop; other site
488538002886	ATP binding site [chemical binding]; other site
488538002887	Q-loop/lid; other site
488538002888	ABC transporter signature motif; other site
488538002889	Walker B; other site
488538002890	D-loop; other site
488538002891	H-loop/switch region; other site
488538002892	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
488538002893	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538002894	Walker A/P-loop; other site
488538002895	ATP binding site [chemical binding]; other site
488538002896	Q-loop/lid; other site
488538002897	ABC transporter signature motif; other site
488538002898	Walker B; other site
488538002899	D-loop; other site
488538002900	H-loop/switch region; other site
488538002901	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488538002902	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
488538002903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002904	dimer interface [polypeptide binding]; other site
488538002905	conserved gate region; other site
488538002906	putative PBP binding loops; other site
488538002907	ABC-ATPase subunit interface; other site
488538002908	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
488538002909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002910	dimer interface [polypeptide binding]; other site
488538002911	conserved gate region; other site
488538002912	putative PBP binding loops; other site
488538002913	ABC-ATPase subunit interface; other site
488538002914	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
488538002915	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
488538002916	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
488538002917	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
488538002918	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
488538002919	Acyltransferase family; Region: Acyl_transf_3; pfam01757
488538002920	Transcriptional regulators [Transcription]; Region: GntR; COG1802
488538002921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488538002922	DNA-binding site [nucleotide binding]; DNA binding site
488538002923	FCD domain; Region: FCD; pfam07729
488538002924	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
488538002925	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
488538002926	homodimer interface [polypeptide binding]; other site
488538002927	substrate-cofactor binding pocket; other site
488538002928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538002929	catalytic residue [active]
488538002930	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488538002931	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488538002932	Walker A/P-loop; other site
488538002933	ATP binding site [chemical binding]; other site
488538002934	Q-loop/lid; other site
488538002935	ABC transporter signature motif; other site
488538002936	Walker B; other site
488538002937	D-loop; other site
488538002938	H-loop/switch region; other site
488538002939	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488538002940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002941	dimer interface [polypeptide binding]; other site
488538002942	conserved gate region; other site
488538002943	putative PBP binding loops; other site
488538002944	ABC-ATPase subunit interface; other site
488538002945	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488538002946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002947	dimer interface [polypeptide binding]; other site
488538002948	conserved gate region; other site
488538002949	putative PBP binding loops; other site
488538002950	ABC-ATPase subunit interface; other site
488538002951	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488538002952	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488538002953	substrate binding pocket [chemical binding]; other site
488538002954	membrane-bound complex binding site; other site
488538002955	hinge residues; other site
488538002956	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
488538002957	Proline dehydrogenase; Region: Pro_dh; cl03282
488538002958	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
488538002959	NAD(P) binding site [chemical binding]; other site
488538002960	catalytic residues [active]
488538002961	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
488538002962	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488538002963	putative DNA binding site [nucleotide binding]; other site
488538002964	putative Zn2+ binding site [ion binding]; other site
488538002965	AsnC family; Region: AsnC_trans_reg; pfam01037
488538002966	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
488538002967	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
488538002968	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
488538002969	sorbitol dehydrogenase; Provisional; Region: PRK07067
488538002970	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538002971	NAD(P) binding site [chemical binding]; other site
488538002972	active site
488538002973	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
488538002974	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
488538002975	Walker A/P-loop; other site
488538002976	ATP binding site [chemical binding]; other site
488538002977	Q-loop/lid; other site
488538002978	ABC transporter signature motif; other site
488538002979	Walker B; other site
488538002980	D-loop; other site
488538002981	H-loop/switch region; other site
488538002982	TOBE domain; Region: TOBE_2; pfam08402
488538002983	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488538002984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002985	dimer interface [polypeptide binding]; other site
488538002986	conserved gate region; other site
488538002987	putative PBP binding loops; other site
488538002988	ABC-ATPase subunit interface; other site
488538002989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538002990	dimer interface [polypeptide binding]; other site
488538002991	conserved gate region; other site
488538002992	putative PBP binding loops; other site
488538002993	ABC-ATPase subunit interface; other site
488538002994	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488538002995	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488538002996	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488538002997	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488538002998	DNA binding site [nucleotide binding]
488538002999	domain linker motif; other site
488538003000	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
488538003001	dimerization interface [polypeptide binding]; other site
488538003002	ligand binding site [chemical binding]; other site
488538003003	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
488538003004	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
488538003005	active site
488538003006	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
488538003007	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538003008	putative substrate binding site [chemical binding]; other site
488538003009	putative ATP binding site [chemical binding]; other site
488538003010	aspartate aminotransferase; Provisional; Region: PRK05764
488538003011	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538003012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003013	homodimer interface [polypeptide binding]; other site
488538003014	catalytic residue [active]
488538003015	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
488538003016	active site
488538003017	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538003018	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
488538003019	putative ADP-binding pocket [chemical binding]; other site
488538003020	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
488538003021	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
488538003022	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538003023	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
488538003024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538003025	NAD(P) binding site [chemical binding]; other site
488538003026	active site
488538003027	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
488538003028	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
488538003029	inhibitor-cofactor binding pocket; inhibition site
488538003030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003031	catalytic residue [active]
488538003032	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
488538003033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538003034	NAD(P) binding site [chemical binding]; other site
488538003035	active site
488538003036	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
488538003037	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
488538003038	substrate binding site; other site
488538003039	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
488538003040	Predicted membrane protein [Function unknown]; Region: COG3463
488538003041	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
488538003042	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
488538003043	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
488538003044	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
488538003045	extended (e) SDRs; Region: SDR_e; cd08946
488538003046	NAD(P) binding site [chemical binding]; other site
488538003047	active site
488538003048	substrate binding site [chemical binding]; other site
488538003049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538003050	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
488538003051	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
488538003052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538003053	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
488538003054	NAD(P) binding site [chemical binding]; other site
488538003055	active site
488538003056	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538003057	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
488538003058	NAD(P) binding site [chemical binding]; other site
488538003059	active site
488538003060	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
488538003061	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
488538003062	active site
488538003063	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
488538003064	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538003065	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
488538003066	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
488538003067	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
488538003068	Ligand binding site; other site
488538003069	Putative Catalytic site; other site
488538003070	DXD motif; other site
488538003071	Methyltransferase domain; Region: Methyltransf_31; pfam13847
488538003072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538003073	S-adenosylmethionine binding site [chemical binding]; other site
488538003074	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
488538003075	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538003076	PYR/PP interface [polypeptide binding]; other site
488538003077	dimer interface [polypeptide binding]; other site
488538003078	TPP binding site [chemical binding]; other site
488538003079	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538003080	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
488538003081	TPP-binding site [chemical binding]; other site
488538003082	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538003083	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
488538003084	active site
488538003085	Int/Topo IB signature motif; other site
488538003086	DNA binding site [nucleotide binding]
488538003087	Helix-turn-helix domain; Region: HTH_17; pfam12728
488538003088	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
488538003089	Thioredoxin; Region: Thioredoxin_4; pfam13462
488538003090	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
488538003091	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
488538003092	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
488538003093	Cu(I) binding site [ion binding]; other site
488538003094	Protein of unknown function (DUF461); Region: DUF461; pfam04314
488538003095	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
488538003096	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
488538003097	Cu(I) binding site [ion binding]; other site
488538003098	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
488538003099	Peptidase family M23; Region: Peptidase_M23; pfam01551
488538003100	Protein of unknown function, DUF; Region: DUF411; cl01142
488538003101	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
488538003102	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
488538003103	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
488538003104	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
488538003105	putative active site [active]
488538003106	catalytic triad [active]
488538003107	putative dimer interface [polypeptide binding]; other site
488538003108	Autotransporter beta-domain; Region: Autotransporter; smart00869
488538003109	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488538003110	active site
488538003111	catalytic residues [active]
488538003112	DNA binding site [nucleotide binding]
488538003113	Int/Topo IB signature motif; other site
488538003114	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538003115	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488538003116	active site
488538003117	catalytic residues [active]
488538003118	DNA binding site [nucleotide binding]
488538003119	Int/Topo IB signature motif; other site
488538003120	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
488538003121	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
488538003122	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
488538003123	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
488538003124	Ligand Binding Site [chemical binding]; other site
488538003125	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
488538003126	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538003127	catalytic loop [active]
488538003128	iron binding site [ion binding]; other site
488538003129	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
488538003130	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
488538003131	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538003132	catalytic residue [active]
488538003133	serine O-acetyltransferase; Region: cysE; TIGR01172
488538003134	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
488538003135	trimer interface [polypeptide binding]; other site
488538003136	active site
488538003137	substrate binding site [chemical binding]; other site
488538003138	CoA binding site [chemical binding]; other site
488538003139	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
488538003140	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
488538003141	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
488538003142	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
488538003143	active site
488538003144	HIGH motif; other site
488538003145	dimer interface [polypeptide binding]; other site
488538003146	KMSKS motif; other site
488538003147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538003148	RNA binding surface [nucleotide binding]; other site
488538003149	Protein of unknown function; Region: DUF3971; pfam13116
488538003150	AsmA-like C-terminal region; Region: AsmA_1; pfam13109
488538003151	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
488538003152	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
488538003153	catalytic triad [active]
488538003154	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
488538003155	dinuclear metal binding motif [ion binding]; other site
488538003156	peptide chain release factor 2; Validated; Region: prfB; PRK00578
488538003157	This domain is found in peptide chain release factors; Region: PCRF; smart00937
488538003158	RF-1 domain; Region: RF-1; pfam00472
488538003159	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
488538003160	Transglycosylase; Region: Transgly; pfam00912
488538003161	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
488538003162	AMIN domain; Region: AMIN; pfam11741
488538003163	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
488538003164	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
488538003165	active site
488538003166	metal binding site [ion binding]; metal-binding site
488538003167	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
488538003168	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
488538003169	homodimer interface [polypeptide binding]; other site
488538003170	oligonucleotide binding site [chemical binding]; other site
488538003171	aspartate aminotransferase; Provisional; Region: PRK05764
488538003172	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538003173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003174	homodimer interface [polypeptide binding]; other site
488538003175	catalytic residue [active]
488538003176	Peptidase family M48; Region: Peptidase_M48; cl12018
488538003177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
488538003178	binding surface
488538003179	TPR motif; other site
488538003180	TPR repeat; Region: TPR_11; pfam13414
488538003181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538003182	TPR motif; other site
488538003183	binding surface
488538003184	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
488538003185	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
488538003186	catalytic residues [active]
488538003187	Dehydroquinase class II; Region: DHquinase_II; pfam01220
488538003188	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
488538003189	trimer interface [polypeptide binding]; other site
488538003190	active site
488538003191	dimer interface [polypeptide binding]; other site
488538003192	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
488538003193	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
488538003194	carboxyltransferase (CT) interaction site; other site
488538003195	biotinylation site [posttranslational modification]; other site
488538003196	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
488538003197	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488538003198	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
488538003199	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
488538003200	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
488538003201	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
488538003202	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
488538003203	mce related protein; Region: MCE; pfam02470
488538003204	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
488538003205	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
488538003206	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
488538003207	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
488538003208	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
488538003209	active site
488538003210	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
488538003211	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
488538003212	TSCPD domain; Region: TSCPD; pfam12637
488538003213	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
488538003214	homotrimer interaction site [polypeptide binding]; other site
488538003215	putative active site [active]
488538003216	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
488538003217	Protein of unknown function, DUF482; Region: DUF482; pfam04339
488538003218	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
488538003219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538003220	Walker A motif; other site
488538003221	ATP binding site [chemical binding]; other site
488538003222	Walker B motif; other site
488538003223	arginine finger; other site
488538003224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538003225	Walker A motif; other site
488538003226	ATP binding site [chemical binding]; other site
488538003227	Walker B motif; other site
488538003228	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
488538003229	Uncharacterized conserved protein [Function unknown]; Region: COG2127
488538003230	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
488538003231	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
488538003232	Sporulation related domain; Region: SPOR; pfam05036
488538003233	Uncharacterized conserved protein [Function unknown]; Region: COG3791
488538003234	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
488538003235	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
488538003236	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
488538003237	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
488538003238	metal binding site [ion binding]; metal-binding site
488538003239	putative dimer interface [polypeptide binding]; other site
488538003240	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
488538003241	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538003242	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
488538003243	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
488538003244	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
488538003245	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538003246	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538003247	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
488538003248	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538003249	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538003250	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538003251	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538003252	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
488538003253	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
488538003254	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
488538003255	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
488538003256	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
488538003257	NAD binding site [chemical binding]; other site
488538003258	homotetramer interface [polypeptide binding]; other site
488538003259	homodimer interface [polypeptide binding]; other site
488538003260	substrate binding site [chemical binding]; other site
488538003261	active site
488538003262	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
488538003263	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
488538003264	Tetramer interface [polypeptide binding]; other site
488538003265	active site
488538003266	FMN-binding site [chemical binding]; other site
488538003267	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
488538003268	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538003269	RNA binding surface [nucleotide binding]; other site
488538003270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538003271	S-adenosylmethionine binding site [chemical binding]; other site
488538003272	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
488538003273	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
488538003274	TPP-binding site; other site
488538003275	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
488538003276	PYR/PP interface [polypeptide binding]; other site
488538003277	dimer interface [polypeptide binding]; other site
488538003278	TPP binding site [chemical binding]; other site
488538003279	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
488538003280	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
488538003281	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
488538003282	substrate binding pocket [chemical binding]; other site
488538003283	chain length determination region; other site
488538003284	substrate-Mg2+ binding site; other site
488538003285	catalytic residues [active]
488538003286	aspartate-rich region 1; other site
488538003287	active site lid residues [active]
488538003288	aspartate-rich region 2; other site
488538003289	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
488538003290	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488538003291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538003292	non-specific DNA binding site [nucleotide binding]; other site
488538003293	salt bridge; other site
488538003294	sequence-specific DNA binding site [nucleotide binding]; other site
488538003295	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
488538003296	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
488538003297	Ferredoxin [Energy production and conversion]; Region: COG1146
488538003298	4Fe-4S binding domain; Region: Fer4; cl02805
488538003299	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
488538003300	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
488538003301	putative metal binding site [ion binding]; other site
488538003302	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538003303	RNA binding surface [nucleotide binding]; other site
488538003304	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538003305	nucleotide binding region [chemical binding]; other site
488538003306	ATP-binding site [chemical binding]; other site
488538003307	aconitate hydratase; Validated; Region: PRK09277
488538003308	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
488538003309	substrate binding site [chemical binding]; other site
488538003310	ligand binding site [chemical binding]; other site
488538003311	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
488538003312	substrate binding site [chemical binding]; other site
488538003313	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
488538003314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538003315	Walker A/P-loop; other site
488538003316	ATP binding site [chemical binding]; other site
488538003317	Q-loop/lid; other site
488538003318	ABC transporter signature motif; other site
488538003319	Walker B; other site
488538003320	D-loop; other site
488538003321	H-loop/switch region; other site
488538003322	CcmB protein; Region: CcmB; cl17444
488538003323	heme exporter protein CcmC; Region: ccmC; TIGR01191
488538003324	Heme exporter protein D (CcmD); Region: CcmD; pfam04995
488538003325	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
488538003326	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538003327	catalytic loop [active]
488538003328	iron binding site [ion binding]; other site
488538003329	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
488538003330	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
488538003331	substrate binding pocket [chemical binding]; other site
488538003332	dimer interface [polypeptide binding]; other site
488538003333	inhibitor binding site; inhibition site
488538003334	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
488538003335	FAD binding site [chemical binding]; other site
488538003336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538003337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538003338	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
488538003339	putative dimerization interface [polypeptide binding]; other site
488538003340	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
488538003341	FAD binding site [chemical binding]; other site
488538003342	Virulence factor; Region: Virulence_fact; pfam13769
488538003343	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
488538003344	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
488538003345	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
488538003346	B12 binding site [chemical binding]; other site
488538003347	cobalt ligand [ion binding]; other site
488538003348	Intracellular septation protein A; Region: IspA; pfam04279
488538003349	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
488538003350	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
488538003351	FMN binding site [chemical binding]; other site
488538003352	active site
488538003353	catalytic residues [active]
488538003354	substrate binding site [chemical binding]; other site
488538003355	Protein of unknown function (DUF1491); Region: DUF1491; cl11568
488538003356	NusB family; Region: NusB; pfam01029
488538003357	16S rRNA methyltransferase B; Provisional; Region: PRK10901
488538003358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538003359	S-adenosylmethionine binding site [chemical binding]; other site
488538003360	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
488538003361	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
488538003362	active site residue [active]
488538003363	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
488538003364	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
488538003365	Chromate transporter; Region: Chromate_transp; pfam02417
488538003366	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
488538003367	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
488538003368	purine monophosphate binding site [chemical binding]; other site
488538003369	dimer interface [polypeptide binding]; other site
488538003370	putative catalytic residues [active]
488538003371	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
488538003372	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
488538003373	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
488538003374	minor groove reading motif; other site
488538003375	helix-hairpin-helix signature motif; other site
488538003376	substrate binding pocket [chemical binding]; other site
488538003377	active site
488538003378	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
488538003379	DNA binding and oxoG recognition site [nucleotide binding]
488538003380	Protein of unknown function (DUF721); Region: DUF721; pfam05258
488538003381	Thioredoxin; Region: Thioredoxin_4; pfam13462
488538003382	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
488538003383	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
488538003384	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
488538003385	Walker A/P-loop; other site
488538003386	ATP binding site [chemical binding]; other site
488538003387	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
488538003388	ABC transporter signature motif; other site
488538003389	Walker B; other site
488538003390	D-loop; other site
488538003391	H-loop/switch region; other site
488538003392	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
488538003393	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
488538003394	ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131
488538003395	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
488538003396	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
488538003397	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
488538003398	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
488538003399	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
488538003400	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
488538003401	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
488538003402	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
488538003403	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
488538003404	putative active site [active]
488538003405	putative substrate binding site [chemical binding]; other site
488538003406	ATP binding site [chemical binding]; other site
488538003407	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
488538003408	RNA/DNA hybrid binding site [nucleotide binding]; other site
488538003409	active site
488538003410	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
488538003411	catalytic triad [active]
488538003412	dimer interface [polypeptide binding]; other site
488538003413	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
488538003414	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
488538003415	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
488538003416	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
488538003417	DsbD alpha interface [polypeptide binding]; other site
488538003418	catalytic residues [active]
488538003419	Putative transcriptional regulator [Transcription]; Region: COG1678
488538003420	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
488538003421	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
488538003422	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
488538003423	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
488538003424	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
488538003425	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003426	catalytic residue [active]
488538003427	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
488538003428	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
488538003429	Subunit III/VIIa interface [polypeptide binding]; other site
488538003430	Phospholipid binding site [chemical binding]; other site
488538003431	Subunit I/III interface [polypeptide binding]; other site
488538003432	Subunit III/VIb interface [polypeptide binding]; other site
488538003433	Subunit III/VIa interface; other site
488538003434	Subunit III/Vb interface [polypeptide binding]; other site
488538003435	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
488538003436	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
488538003437	UbiA prenyltransferase family; Region: UbiA; pfam01040
488538003438	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
488538003439	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
488538003440	Subunit I/III interface [polypeptide binding]; other site
488538003441	D-pathway; other site
488538003442	Subunit I/VIIc interface [polypeptide binding]; other site
488538003443	Subunit I/IV interface [polypeptide binding]; other site
488538003444	Subunit I/II interface [polypeptide binding]; other site
488538003445	Low-spin heme (heme a) binding site [chemical binding]; other site
488538003446	Subunit I/VIIa interface [polypeptide binding]; other site
488538003447	Subunit I/VIa interface [polypeptide binding]; other site
488538003448	Dimer interface; other site
488538003449	Putative water exit pathway; other site
488538003450	Binuclear center (heme a3/CuB) [ion binding]; other site
488538003451	K-pathway; other site
488538003452	Subunit I/Vb interface [polypeptide binding]; other site
488538003453	Putative proton exit pathway; other site
488538003454	Subunit I/VIb interface; other site
488538003455	Subunit I/VIc interface [polypeptide binding]; other site
488538003456	Electron transfer pathway; other site
488538003457	Subunit I/VIIIb interface [polypeptide binding]; other site
488538003458	Subunit I/VIIb interface [polypeptide binding]; other site
488538003459	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
488538003460	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
488538003461	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
488538003462	protease TldD; Provisional; Region: tldD; PRK10735
488538003463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538003464	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538003465	putative substrate translocation pore; other site
488538003466	glutamate--cysteine ligase; Region: PLN02611
488538003467	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
488538003468	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
488538003469	UbiA prenyltransferase family; Region: UbiA; pfam01040
488538003470	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
488538003471	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
488538003472	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
488538003473	Putative phosphatase (DUF442); Region: DUF442; cl17385
488538003474	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488538003475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538003476	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488538003477	Walker A/P-loop; other site
488538003478	ATP binding site [chemical binding]; other site
488538003479	Q-loop/lid; other site
488538003480	ABC transporter signature motif; other site
488538003481	Walker B; other site
488538003482	D-loop; other site
488538003483	H-loop/switch region; other site
488538003484	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
488538003485	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
488538003486	putative active site [active]
488538003487	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
488538003488	putative acyl-acceptor binding pocket; other site
488538003489	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
488538003490	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
488538003491	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
488538003492	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
488538003493	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
488538003494	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
488538003495	putative acyl-acceptor binding pocket; other site
488538003496	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
488538003497	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
488538003498	generic binding surface II; other site
488538003499	generic binding surface I; other site
488538003500	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
488538003501	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
488538003502	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
488538003503	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
488538003504	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
488538003505	nucleoside/Zn binding site; other site
488538003506	dimer interface [polypeptide binding]; other site
488538003507	catalytic motif [active]
488538003508	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
488538003509	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538003510	RNA binding surface [nucleotide binding]; other site
488538003511	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
488538003512	active site
488538003513	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
488538003514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538003515	S-adenosylmethionine binding site [chemical binding]; other site
488538003516	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
488538003517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538003518	ATP binding site [chemical binding]; other site
488538003519	Mg2+ binding site [ion binding]; other site
488538003520	G-X-G motif; other site
488538003521	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
488538003522	ATP binding site [chemical binding]; other site
488538003523	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
488538003524	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
488538003525	lipoprotein signal peptidase; Provisional; Region: PRK14787
488538003526	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
488538003527	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
488538003528	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538003529	active site
488538003530	HIGH motif; other site
488538003531	nucleotide binding site [chemical binding]; other site
488538003532	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
488538003533	active site
488538003534	KMSKS motif; other site
488538003535	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
488538003536	tRNA binding surface [nucleotide binding]; other site
488538003537	anticodon binding site; other site
488538003538	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
488538003539	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
488538003540	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
488538003541	active site
488538003542	Riboflavin kinase; Region: Flavokinase; pfam01687
488538003543	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
488538003544	Mechanosensitive ion channel; Region: MS_channel; pfam00924
488538003545	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
488538003546	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
488538003547	putative active site pocket [active]
488538003548	dimerization interface [polypeptide binding]; other site
488538003549	putative catalytic residue [active]
488538003550	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
488538003551	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
488538003552	diiron binding motif [ion binding]; other site
488538003553	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
488538003554	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
488538003555	active site
488538003556	putative hydrolase; Provisional; Region: PRK11460
488538003557	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
488538003558	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
488538003559	active site
488538003560	HIGH motif; other site
488538003561	nucleotide binding site [chemical binding]; other site
488538003562	active site
488538003563	KMSKS motif; other site
488538003564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538003565	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538003566	putative substrate translocation pore; other site
488538003567	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
488538003568	metal binding site 2 [ion binding]; metal-binding site
488538003569	putative DNA binding helix; other site
488538003570	metal binding site 1 [ion binding]; metal-binding site
488538003571	dimer interface [polypeptide binding]; other site
488538003572	structural Zn2+ binding site [ion binding]; other site
488538003573	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
488538003574	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
488538003575	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
488538003576	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
488538003577	Membrane transport protein; Region: Mem_trans; cl09117
488538003578	BioY family; Region: BioY; pfam02632
488538003579	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
488538003580	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
488538003581	Thiamine pyrophosphokinase; Region: TPK; cd07995
488538003582	active site
488538003583	dimerization interface [polypeptide binding]; other site
488538003584	thiamine binding site [chemical binding]; other site
488538003585	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
488538003586	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
488538003587	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
488538003588	HlyD family secretion protein; Region: HlyD_3; pfam13437
488538003589	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488538003590	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488538003591	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
488538003592	Walker A/P-loop; other site
488538003593	ATP binding site [chemical binding]; other site
488538003594	Q-loop/lid; other site
488538003595	ABC transporter signature motif; other site
488538003596	Walker B; other site
488538003597	D-loop; other site
488538003598	H-loop/switch region; other site
488538003599	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
488538003600	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
488538003601	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
488538003602	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
488538003603	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
488538003604	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
488538003605	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538003606	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
488538003607	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
488538003608	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
488538003609	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
488538003610	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
488538003611	homodimer interface [polypeptide binding]; other site
488538003612	substrate-cofactor binding pocket; other site
488538003613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003614	catalytic residue [active]
488538003615	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
488538003616	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
488538003617	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
488538003618	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
488538003619	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
488538003620	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
488538003621	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
488538003622	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
488538003623	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
488538003624	substrate binding site [chemical binding]; other site
488538003625	oxyanion hole (OAH) forming residues; other site
488538003626	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
488538003627	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
488538003628	active site
488538003629	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
488538003630	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
488538003631	Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598
488538003632	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538003633	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538003634	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538003635	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538003636	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538003637	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538003638	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538003639	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
488538003640	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538003641	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538003642	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488538003643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538003644	non-specific DNA binding site [nucleotide binding]; other site
488538003645	salt bridge; other site
488538003646	sequence-specific DNA binding site [nucleotide binding]; other site
488538003647	Cupin domain; Region: Cupin_2; pfam07883
488538003648	Protein of unknown function (DUF983); Region: DUF983; cl02211
488538003649	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
488538003650	catalytic triad [active]
488538003651	putative active site [active]
488538003652	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
488538003653	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
488538003654	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538003655	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
488538003656	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
488538003657	active site
488538003658	dimer interface [polypeptide binding]; other site
488538003659	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
488538003660	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
488538003661	Walker A/P-loop; other site
488538003662	ATP binding site [chemical binding]; other site
488538003663	Q-loop/lid; other site
488538003664	ABC transporter signature motif; other site
488538003665	Walker B; other site
488538003666	D-loop; other site
488538003667	H-loop/switch region; other site
488538003668	TOBE domain; Region: TOBE_2; pfam08402
488538003669	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
488538003670	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
488538003671	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
488538003672	galactokinase; Provisional; Region: PRK05101
488538003673	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
488538003674	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
488538003675	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
488538003676	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
488538003677	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
488538003678	nucleotide binding site/active site [active]
488538003679	HIT family signature motif; other site
488538003680	catalytic residue [active]
488538003681	alpha-galactosidase; Provisional; Region: PRK15076
488538003682	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
488538003683	NAD binding site [chemical binding]; other site
488538003684	sugar binding site [chemical binding]; other site
488538003685	divalent metal binding site [ion binding]; other site
488538003686	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
488538003687	dimer interface [polypeptide binding]; other site
488538003688	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488538003689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538003690	dimer interface [polypeptide binding]; other site
488538003691	conserved gate region; other site
488538003692	putative PBP binding loops; other site
488538003693	ABC-ATPase subunit interface; other site
488538003694	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
488538003695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538003696	dimer interface [polypeptide binding]; other site
488538003697	conserved gate region; other site
488538003698	putative PBP binding loops; other site
488538003699	ABC-ATPase subunit interface; other site
488538003700	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488538003701	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488538003702	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
488538003703	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488538003704	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
488538003705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538003706	active site
488538003707	phosphorylation site [posttranslational modification]
488538003708	intermolecular recognition site; other site
488538003709	dimerization interface [polypeptide binding]; other site
488538003710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538003711	DNA binding site [nucleotide binding]
488538003712	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
488538003713	PhoU domain; Region: PhoU; pfam01895
488538003714	PhoU domain; Region: PhoU; pfam01895
488538003715	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
488538003716	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
488538003717	Walker A/P-loop; other site
488538003718	ATP binding site [chemical binding]; other site
488538003719	Q-loop/lid; other site
488538003720	ABC transporter signature motif; other site
488538003721	Walker B; other site
488538003722	D-loop; other site
488538003723	H-loop/switch region; other site
488538003724	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
488538003725	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
488538003726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538003727	dimer interface [polypeptide binding]; other site
488538003728	conserved gate region; other site
488538003729	putative PBP binding loops; other site
488538003730	ABC-ATPase subunit interface; other site
488538003731	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
488538003732	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
488538003733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538003734	dimer interface [polypeptide binding]; other site
488538003735	conserved gate region; other site
488538003736	ABC-ATPase subunit interface; other site
488538003737	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
488538003738	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
488538003739	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
488538003740	putative active site [active]
488538003741	heme pocket [chemical binding]; other site
488538003742	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538003743	dimer interface [polypeptide binding]; other site
488538003744	phosphorylation site [posttranslational modification]
488538003745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538003746	ATP binding site [chemical binding]; other site
488538003747	Mg2+ binding site [ion binding]; other site
488538003748	G-X-G motif; other site
488538003749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
488538003750	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
488538003751	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
488538003752	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
488538003753	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
488538003754	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
488538003755	acyl-activating enzyme (AAE) consensus motif; other site
488538003756	acyl-activating enzyme (AAE) consensus motif; other site
488538003757	putative AMP binding site [chemical binding]; other site
488538003758	putative active site [active]
488538003759	putative CoA binding site [chemical binding]; other site
488538003760	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
488538003761	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
488538003762	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
488538003763	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
488538003764	homodimer interface [polypeptide binding]; other site
488538003765	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003766	catalytic residue [active]
488538003767	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488538003768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538003769	non-specific DNA binding site [nucleotide binding]; other site
488538003770	salt bridge; other site
488538003771	sequence-specific DNA binding site [nucleotide binding]; other site
488538003772	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
488538003773	Domain of unknown function (DUF955); Region: DUF955; pfam06114
488538003774	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
488538003775	D-alanyl-alanine synthetase A; Provisional; Region: PRK14569
488538003776	ATP-grasp domain; Region: ATP-grasp_4; cl17255
488538003777	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
488538003778	dimer interface [polypeptide binding]; other site
488538003779	FMN binding site [chemical binding]; other site
488538003780	NADPH bind site [chemical binding]; other site
488538003781	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
488538003782	extended (e) SDRs; Region: SDR_e; cd08946
488538003783	NAD(P) binding site [chemical binding]; other site
488538003784	active site
488538003785	substrate binding site [chemical binding]; other site
488538003786	GTP-binding protein LepA; Provisional; Region: PRK05433
488538003787	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
488538003788	G1 box; other site
488538003789	putative GEF interaction site [polypeptide binding]; other site
488538003790	GTP/Mg2+ binding site [chemical binding]; other site
488538003791	Switch I region; other site
488538003792	G2 box; other site
488538003793	G3 box; other site
488538003794	Switch II region; other site
488538003795	G4 box; other site
488538003796	G5 box; other site
488538003797	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
488538003798	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
488538003799	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
488538003800	2-isopropylmalate synthase; Validated; Region: PRK03739
488538003801	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
488538003802	active site
488538003803	catalytic residues [active]
488538003804	metal binding site [ion binding]; metal-binding site
488538003805	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
488538003806	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
488538003807	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
488538003808	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
488538003809	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
488538003810	Cadherin repeat-like domain; Region: CA_like; cl15786
488538003811	potential protein location (hypothetical protein) that overlaps protein (adenylate/guanylate cyclase)
488538003812	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
488538003813	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
488538003814	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
488538003815	putative tRNA-binding site [nucleotide binding]; other site
488538003816	B3/4 domain; Region: B3_4; pfam03483
488538003817	tRNA synthetase B5 domain; Region: B5; smart00874
488538003818	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
488538003819	motif 1; other site
488538003820	dimer interface [polypeptide binding]; other site
488538003821	motif 3; other site
488538003822	motif 2; other site
488538003823	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
488538003824	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
488538003825	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
488538003826	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
488538003827	dimer interface [polypeptide binding]; other site
488538003828	motif 1; other site
488538003829	active site
488538003830	motif 2; other site
488538003831	motif 3; other site
488538003832	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
488538003833	23S rRNA binding site [nucleotide binding]; other site
488538003834	L21 binding site [polypeptide binding]; other site
488538003835	L13 binding site [polypeptide binding]; other site
488538003836	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
488538003837	LabA_like proteins; Region: LabA_like; cd06167
488538003838	Uncharacterized conserved protein [Function unknown]; Region: COG1432
488538003839	putative metal binding site [ion binding]; other site
488538003840	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
488538003841	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
488538003842	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
488538003843	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
488538003844	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
488538003845	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
488538003846	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
488538003847	active site
488538003848	dimer interface [polypeptide binding]; other site
488538003849	motif 1; other site
488538003850	motif 2; other site
488538003851	motif 3; other site
488538003852	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
488538003853	anticodon binding site; other site
488538003854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538003855	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
488538003856	putative ADP-binding pocket [chemical binding]; other site
488538003857	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
488538003858	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
488538003859	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
488538003860	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
488538003861	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538003862	C-terminal domain interface [polypeptide binding]; other site
488538003863	GSH binding site (G-site) [chemical binding]; other site
488538003864	dimer interface [polypeptide binding]; other site
488538003865	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
488538003866	N-terminal domain interface [polypeptide binding]; other site
488538003867	dimer interface [polypeptide binding]; other site
488538003868	substrate binding pocket (H-site) [chemical binding]; other site
488538003869	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538003870	Coenzyme A binding pocket [chemical binding]; other site
488538003871	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
488538003872	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
488538003873	active site
488538003874	dimer interface [polypeptide binding]; other site
488538003875	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
488538003876	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
488538003877	active site
488538003878	FMN binding site [chemical binding]; other site
488538003879	substrate binding site [chemical binding]; other site
488538003880	3Fe-4S cluster binding site [ion binding]; other site
488538003881	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
488538003882	domain interface; other site
488538003883	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
488538003884	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538003885	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538003886	Bacitracin resistance protein BacA; Region: BacA; pfam02673
488538003887	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
488538003888	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
488538003889	putative NAD(P) binding site [chemical binding]; other site
488538003890	active site
488538003891	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
488538003892	catalytic site [active]
488538003893	putative active site [active]
488538003894	putative substrate binding site [chemical binding]; other site
488538003895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
488538003896	OstA-like protein; Region: OstA; cl00844
488538003897	OstA-like protein; Region: OstA; cl00844
488538003898	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
488538003899	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
488538003900	Walker A/P-loop; other site
488538003901	ATP binding site [chemical binding]; other site
488538003902	Q-loop/lid; other site
488538003903	ABC transporter signature motif; other site
488538003904	Walker B; other site
488538003905	D-loop; other site
488538003906	H-loop/switch region; other site
488538003907	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488538003908	active site
488538003909	phosphorylation site [posttranslational modification]
488538003910	TIGR02300 family protein; Region: FYDLN_acid
488538003911	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
488538003912	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
488538003913	hinge; other site
488538003914	active site
488538003915	cytidylate kinase; Provisional; Region: cmk; PRK00023
488538003916	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
488538003917	CMP-binding site; other site
488538003918	The sites determining sugar specificity; other site
488538003919	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
488538003920	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
488538003921	RNA binding site [nucleotide binding]; other site
488538003922	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
488538003923	RNA binding site [nucleotide binding]; other site
488538003924	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
488538003925	RNA binding site [nucleotide binding]; other site
488538003926	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
488538003927	RNA binding site [nucleotide binding]; other site
488538003928	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
488538003929	RNA binding site [nucleotide binding]; other site
488538003930	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
488538003931	RNA binding site [nucleotide binding]; other site
488538003932	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
488538003933	IHF dimer interface [polypeptide binding]; other site
488538003934	IHF - DNA interface [nucleotide binding]; other site
488538003935	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
488538003936	active site
488538003937	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
488538003938	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
488538003939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538003940	catalytic residue [active]
488538003941	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
488538003942	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
488538003943	substrate binding site [chemical binding]; other site
488538003944	active site
488538003945	catalytic residues [active]
488538003946	heterodimer interface [polypeptide binding]; other site
488538003947	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
488538003948	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
488538003949	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
488538003950	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488538003951	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
488538003952	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
488538003953	catalytic residues [active]
488538003954	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
488538003955	Family description; Region: UvrD_C_2; pfam13538
488538003956	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
488538003957	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
488538003958	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029
488538003959	zinc binding site [ion binding]; other site
488538003960	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
488538003961	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
488538003962	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
488538003963	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
488538003964	homotetramer interface [polypeptide binding]; other site
488538003965	ligand binding site [chemical binding]; other site
488538003966	catalytic site [active]
488538003967	NAD binding site [chemical binding]; other site
488538003968	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
488538003969	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
488538003970	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488538003971	HAMP domain; Region: HAMP; pfam00672
488538003972	dimerization interface [polypeptide binding]; other site
488538003973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538003974	dimer interface [polypeptide binding]; other site
488538003975	phosphorylation site [posttranslational modification]
488538003976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538003977	ATP binding site [chemical binding]; other site
488538003978	Mg2+ binding site [ion binding]; other site
488538003979	G-X-G motif; other site
488538003980	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488538003981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538003982	active site
488538003983	phosphorylation site [posttranslational modification]
488538003984	intermolecular recognition site; other site
488538003985	dimerization interface [polypeptide binding]; other site
488538003986	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538003987	DNA binding site [nucleotide binding]
488538003988	DNA polymerase I; Provisional; Region: PRK05755
488538003989	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
488538003990	active site
488538003991	metal binding site 1 [ion binding]; metal-binding site
488538003992	putative 5' ssDNA interaction site; other site
488538003993	metal binding site 3; metal-binding site
488538003994	metal binding site 2 [ion binding]; metal-binding site
488538003995	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
488538003996	putative DNA binding site [nucleotide binding]; other site
488538003997	putative metal binding site [ion binding]; other site
488538003998	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
488538003999	active site
488538004000	catalytic site [active]
488538004001	substrate binding site [chemical binding]; other site
488538004002	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
488538004003	active site
488538004004	DNA binding site [nucleotide binding]
488538004005	catalytic site [active]
488538004006	Zinc-finger domain; Region: zf-CHCC; pfam10276
488538004007	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
488538004008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538004009	Walker A/P-loop; other site
488538004010	ATP binding site [chemical binding]; other site
488538004011	Q-loop/lid; other site
488538004012	ABC transporter signature motif; other site
488538004013	Walker B; other site
488538004014	D-loop; other site
488538004015	H-loop/switch region; other site
488538004016	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538004017	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488538004018	active site
488538004019	catalytic residues [active]
488538004020	DNA binding site [nucleotide binding]
488538004021	Int/Topo IB signature motif; other site
488538004022	Protein of unknown function (DUF461); Region: DUF461; pfam04314
488538004023	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488538004024	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538004025	Coenzyme A binding pocket [chemical binding]; other site
488538004026	HD domain; Region: HD_4; pfam13328
488538004027	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
488538004028	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
488538004029	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
488538004030	head completion protein; Provisional; Region: 4; PHA02552
488538004031	DNA methylase; Region: N6_N4_Mtase; pfam01555
488538004032	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
488538004033	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
488538004034	multiple promoter invertase; Provisional; Region: mpi; PRK13413
488538004035	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
488538004036	catalytic residues [active]
488538004037	catalytic nucleophile [active]
488538004038	Presynaptic Site I dimer interface [polypeptide binding]; other site
488538004039	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
488538004040	Synaptic Flat tetramer interface [polypeptide binding]; other site
488538004041	Synaptic Site I dimer interface [polypeptide binding]; other site
488538004042	DNA binding site [nucleotide binding]
488538004043	Homeodomain-like domain; Region: HTH_23; pfam13384
488538004044	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
488538004045	Sel1-like repeats; Region: SEL1; smart00671
488538004046	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
488538004047	Part of AAA domain; Region: AAA_19; pfam13245
488538004048	Family description; Region: UvrD_C_2; pfam13538
488538004049	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
488538004050	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
488538004051	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
488538004052	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538004053	active site
488538004054	DNA binding site [nucleotide binding]
488538004055	Int/Topo IB signature motif; other site
488538004056	AIPR protein; Region: AIPR; pfam10592
488538004057	AIPR protein; Region: AIPR; pfam10592
488538004058	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
488538004059	Z1 domain; Region: Z1; pfam10593
488538004060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538004061	ATP binding site [chemical binding]; other site
488538004062	Mg2+ binding site [ion binding]; other site
488538004063	G-X-G motif; other site
488538004064	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
488538004065	cofactor binding site; other site
488538004066	DNA binding site [nucleotide binding]
488538004067	substrate interaction site [chemical binding]; other site
488538004068	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
488538004069	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
488538004070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538004071	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538004072	putative substrate translocation pore; other site
488538004073	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
488538004074	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
488538004075	TPR repeat; Region: TPR_11; pfam13414
488538004076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004077	TPR motif; other site
488538004078	binding surface
488538004079	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
488538004080	TPR repeat; Region: TPR_11; pfam13414
488538004081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004082	binding surface
488538004083	TPR motif; other site
488538004084	TPR repeat; Region: TPR_11; pfam13414
488538004085	TPR repeat; Region: TPR_11; pfam13414
488538004086	TPR repeat; Region: TPR_11; pfam13414
488538004087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004088	binding surface
488538004089	TPR motif; other site
488538004090	TPR repeat; Region: TPR_11; pfam13414
488538004091	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
488538004092	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
488538004093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004094	binding surface
488538004095	TPR motif; other site
488538004096	TPR repeat; Region: TPR_11; pfam13414
488538004097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004098	binding surface
488538004099	TPR motif; other site
488538004100	TPR repeat; Region: TPR_11; pfam13414
488538004101	TPR repeat; Region: TPR_11; pfam13414
488538004102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004103	binding surface
488538004104	TPR motif; other site
488538004105	TPR repeat; Region: TPR_11; pfam13414
488538004106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004107	binding surface
488538004108	TPR motif; other site
488538004109	TPR repeat; Region: TPR_11; pfam13414
488538004110	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004111	binding surface
488538004112	TPR motif; other site
488538004113	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
488538004114	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
488538004115	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
488538004116	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538004117	active site
488538004118	Int/Topo IB signature motif; other site
488538004119	DNA binding site [nucleotide binding]
488538004120	Domain of unknown function (DUF329); Region: DUF329; pfam03884
488538004121	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
488538004122	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
488538004123	Maf-like protein; Region: Maf; pfam02545
488538004124	active site
488538004125	dimer interface [polypeptide binding]; other site
488538004126	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
488538004127	rRNA binding site [nucleotide binding]; other site
488538004128	predicted 30S ribosome binding site; other site
488538004129	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
488538004130	Low molecular weight phosphatase family; Region: LMWPc; cl00105
488538004131	active site
488538004132	hypothetical protein; Provisional; Region: PRK02853
488538004133	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
488538004134	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
488538004135	NAD binding site [chemical binding]; other site
488538004136	dimerization interface [polypeptide binding]; other site
488538004137	product binding site; other site
488538004138	substrate binding site [chemical binding]; other site
488538004139	zinc binding site [ion binding]; other site
488538004140	catalytic residues [active]
488538004141	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
488538004142	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
488538004143	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
488538004144	hinge; other site
488538004145	active site
488538004146	Uncharacterized conserved protein [Function unknown]; Region: COG0398
488538004147	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
488538004148	mercuric reductase; Validated; Region: PRK06370
488538004149	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538004150	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538004151	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488538004152	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
488538004153	FOG: CBS domain [General function prediction only]; Region: COG0517
488538004154	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
488538004155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538004156	Walker A motif; other site
488538004157	ATP binding site [chemical binding]; other site
488538004158	Walker B motif; other site
488538004159	arginine finger; other site
488538004160	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
488538004161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538004162	Walker A motif; other site
488538004163	ATP binding site [chemical binding]; other site
488538004164	Walker B motif; other site
488538004165	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
488538004166	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538004167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538004168	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
488538004169	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
488538004170	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538004171	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
488538004172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538004173	NAD(P) binding site [chemical binding]; other site
488538004174	active site
488538004175	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
488538004176	AIR carboxylase; Region: AIRC; pfam00731
488538004177	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
488538004178	ATP-grasp domain; Region: ATP-grasp; pfam02222
488538004179	Homoserine O-succinyltransferase; Region: HTS; pfam04204
488538004180	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
488538004181	proposed active site lysine [active]
488538004182	conserved cys residue [active]
488538004183	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
488538004184	COQ9; Region: COQ9; pfam08511
488538004185	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
488538004186	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
488538004187	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
488538004188	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
488538004189	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
488538004190	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
488538004191	ligand binding site [chemical binding]; other site
488538004192	homodimer interface [polypeptide binding]; other site
488538004193	NAD(P) binding site [chemical binding]; other site
488538004194	trimer interface B [polypeptide binding]; other site
488538004195	trimer interface A [polypeptide binding]; other site
488538004196	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
488538004197	ABC1 family; Region: ABC1; pfam03109
488538004198	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
488538004199	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
488538004200	active site
488538004201	Zn binding site [ion binding]; other site
488538004202	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
488538004203	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538004204	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
488538004205	lipoyl attachment site [posttranslational modification]; other site
488538004206	glycine dehydrogenase; Provisional; Region: PRK05367
488538004207	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
488538004208	tetramer interface [polypeptide binding]; other site
488538004209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538004210	catalytic residue [active]
488538004211	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
488538004212	tetramer interface [polypeptide binding]; other site
488538004213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538004214	catalytic residue [active]
488538004215	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
488538004216	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
488538004217	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
488538004218	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
488538004219	active site
488538004220	oligomerization interface [polypeptide binding]; other site
488538004221	metal binding site [ion binding]; metal-binding site
488538004222	pantoate--beta-alanine ligase; Region: panC; TIGR00018
488538004223	Pantoate-beta-alanine ligase; Region: PanC; cd00560
488538004224	active site
488538004225	ATP-binding site [chemical binding]; other site
488538004226	pantoate-binding site; other site
488538004227	HXXH motif; other site
488538004228	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
488538004229	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
488538004230	catalytic triad [active]
488538004231	putative active site [active]
488538004232	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488538004233	active site
488538004234	catalytic residues [active]
488538004235	DNA binding site [nucleotide binding]
488538004236	Int/Topo IB signature motif; other site
488538004237	ATP synthase A chain; Region: ATP-synt_A; cl00413
488538004238	rod shape-determining protein MreB; Provisional; Region: PRK13930
488538004239	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
488538004240	nucleotide binding site [chemical binding]; other site
488538004241	putative NEF/HSP70 interaction site [polypeptide binding]; other site
488538004242	SBD interface [polypeptide binding]; other site
488538004243	tellurite resistance protein terB; Region: terB; cd07176
488538004244	putative metal binding site [ion binding]; other site
488538004245	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
488538004246	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
488538004247	cofactor binding site; other site
488538004248	DNA binding site [nucleotide binding]
488538004249	substrate interaction site [chemical binding]; other site
488538004250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538004251	S-adenosylmethionine binding site [chemical binding]; other site
488538004252	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
488538004253	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
488538004254	active site
488538004255	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
488538004256	nucleotide binding site/active site [active]
488538004257	HIT family signature motif; other site
488538004258	catalytic residue [active]
488538004259	helicase 45; Provisional; Region: PTZ00424
488538004260	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
488538004261	ATP binding site [chemical binding]; other site
488538004262	Mg++ binding site [ion binding]; other site
488538004263	motif III; other site
488538004264	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538004265	nucleotide binding region [chemical binding]; other site
488538004266	ATP-binding site [chemical binding]; other site
488538004267	acyl-CoA synthetase; Validated; Region: PRK08162
488538004268	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
488538004269	acyl-activating enzyme (AAE) consensus motif; other site
488538004270	putative active site [active]
488538004271	AMP binding site [chemical binding]; other site
488538004272	putative CoA binding site [chemical binding]; other site
488538004273	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
488538004274	CoA-transferase family III; Region: CoA_transf_3; pfam02515
488538004275	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
488538004276	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538004277	PYR/PP interface [polypeptide binding]; other site
488538004278	dimer interface [polypeptide binding]; other site
488538004279	TPP binding site [chemical binding]; other site
488538004280	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538004281	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
488538004282	TPP-binding site [chemical binding]; other site
488538004283	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538004284	DctM-like transporters; Region: DctM; pfam06808
488538004285	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
488538004286	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
488538004287	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
488538004288	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538004289	xanthine permease; Region: pbuX; TIGR03173
488538004290	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
488538004291	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
488538004292	active site
488538004293	putative substrate binding pocket [chemical binding]; other site
488538004294	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
488538004295	allantoicase; Provisional; Region: PRK13257
488538004296	Allantoicase repeat; Region: Allantoicase; pfam03561
488538004297	Allantoicase repeat; Region: Allantoicase; pfam03561
488538004298	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
488538004299	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
488538004300	active site
488538004301	catalytic site [active]
488538004302	tetramer interface [polypeptide binding]; other site
488538004303	Predicted membrane protein [Function unknown]; Region: COG3748
488538004304	Protein of unknown function (DUF989); Region: DUF989; pfam06181
488538004305	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
488538004306	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
488538004307	XdhC Rossmann domain; Region: XdhC_C; pfam13478
488538004308	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
488538004309	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
488538004310	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
488538004311	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
488538004312	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
488538004313	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
488538004314	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
488538004315	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
488538004316	active site
488538004317	homotetramer interface [polypeptide binding]; other site
488538004318	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
488538004319	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
488538004320	FAD binding domain; Region: FAD_binding_4; pfam01565
488538004321	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
488538004322	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
488538004323	tetrameric interface [polypeptide binding]; other site
488538004324	NAD binding site [chemical binding]; other site
488538004325	catalytic residues [active]
488538004326	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
488538004327	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
488538004328	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
488538004329	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
488538004330	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
488538004331	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
488538004332	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
488538004333	Walker A/P-loop; other site
488538004334	ATP binding site [chemical binding]; other site
488538004335	Q-loop/lid; other site
488538004336	ABC transporter signature motif; other site
488538004337	Walker B; other site
488538004338	D-loop; other site
488538004339	H-loop/switch region; other site
488538004340	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
488538004341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004342	dimer interface [polypeptide binding]; other site
488538004343	conserved gate region; other site
488538004344	putative PBP binding loops; other site
488538004345	ABC-ATPase subunit interface; other site
488538004346	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
488538004347	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
488538004348	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
488538004349	active site
488538004350	intersubunit interface [polypeptide binding]; other site
488538004351	Zn2+ binding site [ion binding]; other site
488538004352	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
488538004353	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
488538004354	NAD(P) binding site [chemical binding]; other site
488538004355	catalytic residues [active]
488538004356	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
488538004357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538004358	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
488538004359	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488538004360	putative DNA binding site [nucleotide binding]; other site
488538004361	putative Zn2+ binding site [ion binding]; other site
488538004362	AsnC family; Region: AsnC_trans_reg; pfam01037
488538004363	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
488538004364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538004365	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
488538004366	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
488538004367	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
488538004368	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
488538004369	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
488538004370	conserved cys residue [active]
488538004371	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488538004372	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
488538004373	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
488538004374	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
488538004375	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
488538004376	B12 binding site [chemical binding]; other site
488538004377	cobalt ligand [ion binding]; other site
488538004378	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
488538004379	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
488538004380	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
488538004381	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
488538004382	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
488538004383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
488538004384	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
488538004385	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
488538004386	active site
488538004387	dimer interface [polypeptide binding]; other site
488538004388	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
488538004389	DNA-binding site [nucleotide binding]; DNA binding site
488538004390	RNA-binding motif; other site
488538004391	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
488538004392	DNA-binding site [nucleotide binding]; DNA binding site
488538004393	RNA-binding motif; other site
488538004394	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
488538004395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538004396	putative substrate translocation pore; other site
488538004397	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
488538004398	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538004399	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538004400	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
488538004401	Peptidase family M23; Region: Peptidase_M23; pfam01551
488538004402	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
488538004403	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
488538004404	putative NAD(P) binding site [chemical binding]; other site
488538004405	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
488538004406	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
488538004407	intersubunit interface [polypeptide binding]; other site
488538004408	active site
488538004409	zinc binding site [ion binding]; other site
488538004410	Na+ binding site [ion binding]; other site
488538004411	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
488538004412	AMP binding site [chemical binding]; other site
488538004413	metal binding site [ion binding]; metal-binding site
488538004414	active site
488538004415	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
488538004416	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
488538004417	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
488538004418	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488538004419	FeS/SAM binding site; other site
488538004420	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
488538004421	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
488538004422	active site
488538004423	catalytic triad [active]
488538004424	oxyanion hole [active]
488538004425	switch loop; other site
488538004426	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
488538004427	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488538004428	Walker A/P-loop; other site
488538004429	ATP binding site [chemical binding]; other site
488538004430	Q-loop/lid; other site
488538004431	ABC transporter signature motif; other site
488538004432	Walker B; other site
488538004433	D-loop; other site
488538004434	H-loop/switch region; other site
488538004435	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
488538004436	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
488538004437	FtsX-like permease family; Region: FtsX; pfam02687
488538004438	argininosuccinate synthase; Provisional; Region: PRK13820
488538004439	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
488538004440	ANP binding site [chemical binding]; other site
488538004441	Substrate Binding Site II [chemical binding]; other site
488538004442	Substrate Binding Site I [chemical binding]; other site
488538004443	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
488538004444	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
488538004445	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
488538004446	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
488538004447	trimer interface [polypeptide binding]; other site
488538004448	putative metal binding site [ion binding]; other site
488538004449	succinic semialdehyde dehydrogenase; Region: PLN02278
488538004450	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
488538004451	tetramerization interface [polypeptide binding]; other site
488538004452	NAD(P) binding site [chemical binding]; other site
488538004453	catalytic residues [active]
488538004454	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
488538004455	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
488538004456	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538004457	active site
488538004458	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488538004459	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
488538004460	active site
488538004461	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
488538004462	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
488538004463	NADP binding site [chemical binding]; other site
488538004464	dimer interface [polypeptide binding]; other site
488538004465	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
488538004466	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
488538004467	cyclase homology domain; Region: CHD; cd07302
488538004468	nucleotidyl binding site; other site
488538004469	metal binding site [ion binding]; metal-binding site
488538004470	dimer interface [polypeptide binding]; other site
488538004471	PAS domain; Region: PAS_9; pfam13426
488538004472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
488538004473	putative active site [active]
488538004474	heme pocket [chemical binding]; other site
488538004475	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
488538004476	TPR repeat; Region: TPR_11; pfam13414
488538004477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004478	TPR motif; other site
488538004479	binding surface
488538004480	Tetratricopeptide repeat; Region: TPR_16; pfam13432
488538004481	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
488538004482	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
488538004483	pyruvate kinase; Provisional; Region: PRK06247
488538004484	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
488538004485	domain interfaces; other site
488538004486	active site
488538004487	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
488538004488	NMT1-like family; Region: NMT1_2; pfam13379
488538004489	NMT1/THI5 like; Region: NMT1; pfam09084
488538004490	membrane-bound complex binding site; other site
488538004491	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
488538004492	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
488538004493	Walker A/P-loop; other site
488538004494	ATP binding site [chemical binding]; other site
488538004495	Q-loop/lid; other site
488538004496	ABC transporter signature motif; other site
488538004497	Walker B; other site
488538004498	D-loop; other site
488538004499	H-loop/switch region; other site
488538004500	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
488538004501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004502	dimer interface [polypeptide binding]; other site
488538004503	conserved gate region; other site
488538004504	putative PBP binding loops; other site
488538004505	ABC-ATPase subunit interface; other site
488538004506	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
488538004507	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
488538004508	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538004509	catalytic residue [active]
488538004510	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488538004511	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488538004512	substrate binding pocket [chemical binding]; other site
488538004513	membrane-bound complex binding site; other site
488538004514	hinge residues; other site
488538004515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004516	dimer interface [polypeptide binding]; other site
488538004517	conserved gate region; other site
488538004518	putative PBP binding loops; other site
488538004519	ABC-ATPase subunit interface; other site
488538004520	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488538004521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004522	dimer interface [polypeptide binding]; other site
488538004523	conserved gate region; other site
488538004524	putative PBP binding loops; other site
488538004525	ABC-ATPase subunit interface; other site
488538004526	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488538004527	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488538004528	Walker A/P-loop; other site
488538004529	ATP binding site [chemical binding]; other site
488538004530	Q-loop/lid; other site
488538004531	ABC transporter signature motif; other site
488538004532	Walker B; other site
488538004533	D-loop; other site
488538004534	H-loop/switch region; other site
488538004535	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538004536	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
488538004537	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
488538004538	molybdopterin cofactor binding site [chemical binding]; other site
488538004539	substrate binding site [chemical binding]; other site
488538004540	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
488538004541	molybdopterin cofactor binding site; other site
488538004542	putative inner membrane protein; Provisional; Region: PRK11099
488538004543	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
488538004544	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
488538004545	active site residue [active]
488538004546	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
488538004547	active site residue [active]
488538004548	EamA-like transporter family; Region: EamA; cl17759
488538004549	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538004550	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
488538004551	ArsC family; Region: ArsC; pfam03960
488538004552	catalytic residues [active]
488538004553	short chain dehydrogenase; Provisional; Region: PRK06198
488538004554	classical (c) SDRs; Region: SDR_c; cd05233
488538004555	NAD(P) binding site [chemical binding]; other site
488538004556	active site
488538004557	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
488538004558	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
488538004559	putative ligand binding site [chemical binding]; other site
488538004560	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538004561	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488538004562	TM-ABC transporter signature motif; other site
488538004563	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
488538004564	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488538004565	TM-ABC transporter signature motif; other site
488538004566	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538004567	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
488538004568	Walker A/P-loop; other site
488538004569	ATP binding site [chemical binding]; other site
488538004570	Q-loop/lid; other site
488538004571	ABC transporter signature motif; other site
488538004572	Walker B; other site
488538004573	D-loop; other site
488538004574	H-loop/switch region; other site
488538004575	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488538004576	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488538004577	Walker A/P-loop; other site
488538004578	ATP binding site [chemical binding]; other site
488538004579	Q-loop/lid; other site
488538004580	ABC transporter signature motif; other site
488538004581	Walker B; other site
488538004582	D-loop; other site
488538004583	H-loop/switch region; other site
488538004584	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
488538004585	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
488538004586	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538004587	catalytic residue [active]
488538004588	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
488538004589	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
488538004590	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538004591	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488538004592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538004593	non-specific DNA binding site [nucleotide binding]; other site
488538004594	salt bridge; other site
488538004595	sequence-specific DNA binding site [nucleotide binding]; other site
488538004596	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
488538004597	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
488538004598	active site
488538004599	DNA binding site [nucleotide binding]
488538004600	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
488538004601	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
488538004602	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
488538004603	Catalytic site [active]
488538004604	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
488538004605	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
488538004606	HemY protein N-terminus; Region: HemY_N; pfam07219
488538004607	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
488538004608	active site
488538004609	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
488538004610	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
488538004611	domain interfaces; other site
488538004612	active site
488538004613	UGMP family protein; Validated; Region: PRK09604
488538004614	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
488538004615	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
488538004616	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
488538004617	EVE domain; Region: EVE; pfam01878
488538004618	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
488538004619	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
488538004620	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
488538004621	active site
488538004622	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
488538004623	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
488538004624	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
488538004625	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
488538004626	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
488538004627	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
488538004628	interface (dimer of trimers) [polypeptide binding]; other site
488538004629	Substrate-binding/catalytic site; other site
488538004630	Zn-binding sites [ion binding]; other site
488538004631	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
488538004632	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
488538004633	putative ligand binding site [chemical binding]; other site
488538004634	NAD binding site [chemical binding]; other site
488538004635	dimerization interface [polypeptide binding]; other site
488538004636	catalytic site [active]
488538004637	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
488538004638	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
488538004639	active site
488538004640	Cytochrome c2 [Energy production and conversion]; Region: COG3474
488538004641	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
488538004642	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
488538004643	Ligand binding site; other site
488538004644	oligomer interface; other site
488538004645	prephenate dehydratase; Provisional; Region: PRK11899
488538004646	Prephenate dehydratase; Region: PDT; pfam00800
488538004647	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
488538004648	putative L-Phe binding site [chemical binding]; other site
488538004649	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
488538004650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538004651	Walker A motif; other site
488538004652	ATP binding site [chemical binding]; other site
488538004653	Walker B motif; other site
488538004654	arginine finger; other site
488538004655	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
488538004656	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
488538004657	hypothetical protein; Validated; Region: PRK00153
488538004658	recombination protein RecR; Reviewed; Region: recR; PRK00076
488538004659	RecR protein; Region: RecR; pfam02132
488538004660	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
488538004661	putative active site [active]
488538004662	putative metal-binding site [ion binding]; other site
488538004663	tetramer interface [polypeptide binding]; other site
488538004664	RmuC family; Region: RmuC; pfam02646
488538004665	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
488538004666	active site
488538004667	catalytic residues [active]
488538004668	metal binding site [ion binding]; metal-binding site
488538004669	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
488538004670	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
488538004671	putative active site [active]
488538004672	substrate binding site [chemical binding]; other site
488538004673	putative cosubstrate binding site; other site
488538004674	catalytic site [active]
488538004675	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
488538004676	substrate binding site [chemical binding]; other site
488538004677	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
488538004678	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
488538004679	dimerization interface 3.5A [polypeptide binding]; other site
488538004680	active site
488538004681	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
488538004682	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
488538004683	metal binding site [ion binding]; metal-binding site
488538004684	dimer interface [polypeptide binding]; other site
488538004685	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
488538004686	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
488538004687	trimer interface [polypeptide binding]; other site
488538004688	active site
488538004689	substrate binding site [chemical binding]; other site
488538004690	CoA binding site [chemical binding]; other site
488538004691	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
488538004692	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488538004693	motif II; other site
488538004694	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
488538004695	feedback inhibition sensing region; other site
488538004696	homohexameric interface [polypeptide binding]; other site
488538004697	nucleotide binding site [chemical binding]; other site
488538004698	N-acetyl-L-glutamate binding site [chemical binding]; other site
488538004699	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
488538004700	G1 box; other site
488538004701	GTP/Mg2+ binding site [chemical binding]; other site
488538004702	Switch I region; other site
488538004703	G2 box; other site
488538004704	G3 box; other site
488538004705	Switch II region; other site
488538004706	G4 box; other site
488538004707	G5 box; other site
488538004708	membrane protein insertase; Provisional; Region: PRK01318
488538004709	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
488538004710	Ribonuclease P; Region: Ribonuclease_P; pfam00825
488538004711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488538004712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538004713	ATP binding site [chemical binding]; other site
488538004714	Mg2+ binding site [ion binding]; other site
488538004715	G-X-G motif; other site
488538004716	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538004717	active site
488538004718	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
488538004719	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538004720	active site
488538004721	Int/Topo IB signature motif; other site
488538004722	DNA binding site [nucleotide binding]
488538004723	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
488538004724	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
488538004725	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
488538004726	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
488538004727	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
488538004728	substrate binding [chemical binding]; other site
488538004729	active site
488538004730	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
488538004731	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488538004732	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488538004733	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488538004734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004735	dimer interface [polypeptide binding]; other site
488538004736	conserved gate region; other site
488538004737	putative PBP binding loops; other site
488538004738	ABC-ATPase subunit interface; other site
488538004739	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
488538004740	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
488538004741	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
488538004742	Walker A/P-loop; other site
488538004743	ATP binding site [chemical binding]; other site
488538004744	Q-loop/lid; other site
488538004745	ABC transporter signature motif; other site
488538004746	Walker B; other site
488538004747	D-loop; other site
488538004748	H-loop/switch region; other site
488538004749	MarR family; Region: MarR_2; pfam12802
488538004750	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
488538004751	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488538004752	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
488538004753	integrase; Provisional; Region: int; PHA02601
488538004754	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538004755	active site
488538004756	DNA binding site [nucleotide binding]
488538004757	Int/Topo IB signature motif; other site
488538004758	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
488538004759	putative uracil binding site [chemical binding]; other site
488538004760	putative active site [active]
488538004761	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
488538004762	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538004763	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488538004764	Coenzyme A binding pocket [chemical binding]; other site
488538004765	active site
488538004766	DNA binding site [nucleotide binding]
488538004767	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
488538004768	catalytic site [active]
488538004769	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538004770	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538004771	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
488538004772	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538004773	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538004774	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
488538004775	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538004776	Walker A/P-loop; other site
488538004777	ATP binding site [chemical binding]; other site
488538004778	Q-loop/lid; other site
488538004779	ABC transporter signature motif; other site
488538004780	Walker B; other site
488538004781	D-loop; other site
488538004782	H-loop/switch region; other site
488538004783	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
488538004784	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
488538004785	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488538004786	Walker A/P-loop; other site
488538004787	ATP binding site [chemical binding]; other site
488538004788	Q-loop/lid; other site
488538004789	ABC transporter signature motif; other site
488538004790	Walker B; other site
488538004791	D-loop; other site
488538004792	H-loop/switch region; other site
488538004793	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488538004794	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
488538004795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004796	dimer interface [polypeptide binding]; other site
488538004797	conserved gate region; other site
488538004798	putative PBP binding loops; other site
488538004799	ABC-ATPase subunit interface; other site
488538004800	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
488538004801	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
488538004802	metal binding site [ion binding]; metal-binding site
488538004803	substrate binding pocket [chemical binding]; other site
488538004804	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
488538004805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538004806	dimer interface [polypeptide binding]; other site
488538004807	conserved gate region; other site
488538004808	putative PBP binding loops; other site
488538004809	ABC-ATPase subunit interface; other site
488538004810	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
488538004811	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
488538004812	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
488538004813	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
488538004814	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
488538004815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538004816	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
488538004817	dimerization interface [polypeptide binding]; other site
488538004818	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
488538004819	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
488538004820	Active Sites [active]
488538004821	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
488538004822	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
488538004823	CysD dimerization site [polypeptide binding]; other site
488538004824	G1 box; other site
488538004825	putative GEF interaction site [polypeptide binding]; other site
488538004826	GTP/Mg2+ binding site [chemical binding]; other site
488538004827	Switch I region; other site
488538004828	G2 box; other site
488538004829	G3 box; other site
488538004830	Switch II region; other site
488538004831	G4 box; other site
488538004832	G5 box; other site
488538004833	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
488538004834	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
488538004835	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
488538004836	ligand-binding site [chemical binding]; other site
488538004837	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
488538004838	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
488538004839	active site
488538004840	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
488538004841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004842	binding surface
488538004843	TPR motif; other site
488538004844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004845	binding surface
488538004846	TPR motif; other site
488538004847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538004848	TPR motif; other site
488538004849	binding surface
488538004850	TPR repeat; Region: TPR_11; pfam13414
488538004851	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
488538004852	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
488538004853	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
488538004854	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
488538004855	putative active site [active]
488538004856	putative metal binding site [ion binding]; other site
488538004857	LrgA family; Region: LrgA; pfam03788
488538004858	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
488538004859	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
488538004860	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
488538004861	putative NAD(P) binding site [chemical binding]; other site
488538004862	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
488538004863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
488538004864	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
488538004865	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
488538004866	Pirin-related protein [General function prediction only]; Region: COG1741
488538004867	Pirin; Region: Pirin; pfam02678
488538004868	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
488538004869	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
488538004870	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
488538004871	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
488538004872	ligand binding site [chemical binding]; other site
488538004873	Domain of unknown function (DUF336); Region: DUF336; cl01249
488538004874	EamA-like transporter family; Region: EamA; pfam00892
488538004875	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538004876	EamA-like transporter family; Region: EamA; pfam00892
488538004877	EamA-like transporter family; Region: EamA; pfam00892
488538004878	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
488538004879	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
488538004880	homodimer interface [polypeptide binding]; other site
488538004881	substrate-cofactor binding pocket; other site
488538004882	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538004883	catalytic residue [active]
488538004884	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
488538004885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538004886	active site
488538004887	phosphorylation site [posttranslational modification]
488538004888	intermolecular recognition site; other site
488538004889	dimerization interface [polypeptide binding]; other site
488538004890	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488538004891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538004892	ATP binding site [chemical binding]; other site
488538004893	Mg2+ binding site [ion binding]; other site
488538004894	G-X-G motif; other site
488538004895	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
488538004896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538004897	Mg2+ binding site [ion binding]; other site
488538004898	G-X-G motif; other site
488538004899	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
488538004900	anchoring element; other site
488538004901	dimer interface [polypeptide binding]; other site
488538004902	ATP binding site [chemical binding]; other site
488538004903	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
488538004904	active site
488538004905	putative metal-binding site [ion binding]; other site
488538004906	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
488538004907	recombination protein F; Reviewed; Region: recF; PRK00064
488538004908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538004909	Walker A/P-loop; other site
488538004910	ATP binding site [chemical binding]; other site
488538004911	Q-loop/lid; other site
488538004912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538004913	ABC transporter signature motif; other site
488538004914	Walker B; other site
488538004915	D-loop; other site
488538004916	H-loop/switch region; other site
488538004917	DNA polymerase III subunit beta; Validated; Region: PRK05643
488538004918	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
488538004919	putative DNA binding surface [nucleotide binding]; other site
488538004920	dimer interface [polypeptide binding]; other site
488538004921	beta-clamp/clamp loader binding surface; other site
488538004922	beta-clamp/translesion DNA polymerase binding surface; other site
488538004923	DnaA N-terminal domain; Region: DnaA_N; pfam11638
488538004924	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
488538004925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538004926	Walker A motif; other site
488538004927	ATP binding site [chemical binding]; other site
488538004928	Walker B motif; other site
488538004929	arginine finger; other site
488538004930	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
488538004931	DnaA box-binding interface [nucleotide binding]; other site
488538004932	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
488538004933	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
488538004934	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
488538004935	DNA binding site [nucleotide binding]
488538004936	catalytic residue [active]
488538004937	H2TH interface [polypeptide binding]; other site
488538004938	putative catalytic residues [active]
488538004939	turnover-facilitating residue; other site
488538004940	intercalation triad [nucleotide binding]; other site
488538004941	8OG recognition residue [nucleotide binding]; other site
488538004942	putative reading head residues; other site
488538004943	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
488538004944	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
488538004945	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
488538004946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538004947	S-adenosylmethionine binding site [chemical binding]; other site
488538004948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
488538004949	ABC1 family; Region: ABC1; cl17513
488538004950	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
488538004951	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
488538004952	Flavoprotein; Region: Flavoprotein; pfam02441
488538004953	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
488538004954	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
488538004955	trimer interface [polypeptide binding]; other site
488538004956	active site
488538004957	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
488538004958	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
488538004959	ATP binding site [chemical binding]; other site
488538004960	substrate interface [chemical binding]; other site
488538004961	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
488538004962	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
488538004963	dimerization interface [polypeptide binding]; other site
488538004964	ligand binding site [chemical binding]; other site
488538004965	NADP binding site [chemical binding]; other site
488538004966	catalytic site [active]
488538004967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
488538004968	Bacterial SH3 domain; Region: SH3_4; pfam06347
488538004969	Bacterial SH3 domain; Region: SH3_4; pfam06347
488538004970	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
488538004971	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
488538004972	dimer interface [polypeptide binding]; other site
488538004973	active site
488538004974	heme binding site [chemical binding]; other site
488538004975	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
488538004976	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
488538004977	metal binding site 2 [ion binding]; metal-binding site
488538004978	putative DNA binding helix; other site
488538004979	metal binding site 1 [ion binding]; metal-binding site
488538004980	structural Zn2+ binding site [ion binding]; other site
488538004981	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
488538004982	active site 1 [active]
488538004983	dimer interface [polypeptide binding]; other site
488538004984	active site 2 [active]
488538004985	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
488538004986	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
488538004987	dimer interface [polypeptide binding]; other site
488538004988	active site
488538004989	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
488538004990	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
488538004991	NAD binding site [chemical binding]; other site
488538004992	homotetramer interface [polypeptide binding]; other site
488538004993	homodimer interface [polypeptide binding]; other site
488538004994	substrate binding site [chemical binding]; other site
488538004995	active site
488538004996	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
488538004997	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
488538004998	NAD binding site [chemical binding]; other site
488538004999	homodimer interface [polypeptide binding]; other site
488538005000	active site
488538005001	substrate binding site [chemical binding]; other site
488538005002	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
488538005003	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
488538005004	RNase E interface [polypeptide binding]; other site
488538005005	trimer interface [polypeptide binding]; other site
488538005006	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
488538005007	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
488538005008	RNase E interface [polypeptide binding]; other site
488538005009	trimer interface [polypeptide binding]; other site
488538005010	active site
488538005011	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
488538005012	putative nucleic acid binding region [nucleotide binding]; other site
488538005013	G-X-X-G motif; other site
488538005014	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
488538005015	RNA binding site [nucleotide binding]; other site
488538005016	domain interface; other site
488538005017	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
488538005018	16S/18S rRNA binding site [nucleotide binding]; other site
488538005019	S13e-L30e interaction site [polypeptide binding]; other site
488538005020	25S rRNA binding site [nucleotide binding]; other site
488538005021	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
488538005022	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
488538005023	RNA binding site [nucleotide binding]; other site
488538005024	active site
488538005025	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
488538005026	translation initiation factor IF-2; Validated; Region: infB; PRK05306
488538005027	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
488538005028	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
488538005029	G1 box; other site
488538005030	putative GEF interaction site [polypeptide binding]; other site
488538005031	GTP/Mg2+ binding site [chemical binding]; other site
488538005032	Switch I region; other site
488538005033	G2 box; other site
488538005034	G3 box; other site
488538005035	Switch II region; other site
488538005036	G4 box; other site
488538005037	G5 box; other site
488538005038	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
488538005039	Translation-initiation factor 2; Region: IF-2; pfam11987
488538005040	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
488538005041	hypothetical protein; Provisional; Region: PRK09190
488538005042	Protein of unknown function (DUF448); Region: DUF448; pfam04296
488538005043	putative RNA binding cleft [nucleotide binding]; other site
488538005044	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
488538005045	NusA N-terminal domain; Region: NusA_N; pfam08529
488538005046	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
488538005047	RNA binding site [nucleotide binding]; other site
488538005048	homodimer interface [polypeptide binding]; other site
488538005049	NusA-like KH domain; Region: KH_5; pfam13184
488538005050	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
488538005051	G-X-X-G motif; other site
488538005052	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
488538005053	ribosome maturation protein RimP; Reviewed; Region: PRK00092
488538005054	Sm and related proteins; Region: Sm_like; cl00259
488538005055	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
488538005056	putative oligomer interface [polypeptide binding]; other site
488538005057	putative RNA binding site [nucleotide binding]; other site
488538005058	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
488538005059	S-adenosylmethionine synthetase; Validated; Region: PRK05250
488538005060	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
488538005061	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
488538005062	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
488538005063	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
488538005064	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
488538005065	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
488538005066	putative active site [active]
488538005067	catalytic triad [active]
488538005068	putative dimer interface [polypeptide binding]; other site
488538005069	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
488538005070	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
488538005071	Transporter associated domain; Region: CorC_HlyC; smart01091
488538005072	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
488538005073	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
488538005074	PhoH-like protein; Region: PhoH; pfam02562
488538005075	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
488538005076	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
488538005077	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488538005078	FeS/SAM binding site; other site
488538005079	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
488538005080	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488538005081	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
488538005082	Glycoprotease family; Region: Peptidase_M22; pfam00814
488538005083	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
488538005084	putative active site [active]
488538005085	putative metal binding site [ion binding]; other site
488538005086	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
488538005087	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
488538005088	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
488538005089	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
488538005090	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
488538005091	active site
488538005092	HIGH motif; other site
488538005093	dimer interface [polypeptide binding]; other site
488538005094	KMSKS motif; other site
488538005095	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538005096	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
488538005097	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
488538005098	PII uridylyl-transferase; Provisional; Region: PRK05092
488538005099	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
488538005100	metal binding triad; other site
488538005101	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
488538005102	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488538005103	Zn2+ binding site [ion binding]; other site
488538005104	Mg2+ binding site [ion binding]; other site
488538005105	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
488538005106	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
488538005107	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
488538005108	MutS domain I; Region: MutS_I; pfam01624
488538005109	MutS domain II; Region: MutS_II; pfam05188
488538005110	MutS domain III; Region: MutS_III; pfam05192
488538005111	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
488538005112	Walker A/P-loop; other site
488538005113	ATP binding site [chemical binding]; other site
488538005114	Q-loop/lid; other site
488538005115	ABC transporter signature motif; other site
488538005116	Walker B; other site
488538005117	D-loop; other site
488538005118	H-loop/switch region; other site
488538005119	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
488538005120	Malic enzyme, N-terminal domain; Region: malic; pfam00390
488538005121	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
488538005122	putative NAD(P) binding site [chemical binding]; other site
488538005123	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
488538005124	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538005125	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
488538005126	substrate binding site [chemical binding]; other site
488538005127	ATP binding site [chemical binding]; other site
488538005128	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
488538005129	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
488538005130	minor groove reading motif; other site
488538005131	helix-hairpin-helix signature motif; other site
488538005132	substrate binding pocket [chemical binding]; other site
488538005133	active site
488538005134	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
488538005135	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
488538005136	active site
488538005137	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
488538005138	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
488538005139	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
488538005140	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
488538005141	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
488538005142	ligand binding site [chemical binding]; other site
488538005143	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
488538005144	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
488538005145	Walker A/P-loop; other site
488538005146	ATP binding site [chemical binding]; other site
488538005147	Q-loop/lid; other site
488538005148	ABC transporter signature motif; other site
488538005149	Walker B; other site
488538005150	D-loop; other site
488538005151	H-loop/switch region; other site
488538005152	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
488538005153	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
488538005154	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538005155	TM-ABC transporter signature motif; other site
488538005156	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538005157	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
488538005158	TM-ABC transporter signature motif; other site
488538005159	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
488538005160	active site
488538005161	catalytic motif [active]
488538005162	Zn binding site [ion binding]; other site
488538005163	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538005164	active site
488538005165	thymidine kinase; Provisional; Region: PRK04296
488538005166	dihydrodipicolinate reductase; Provisional; Region: PRK00048
488538005167	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
488538005168	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
488538005169	chaperone protein DnaJ; Provisional; Region: PRK10767
488538005170	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
488538005171	HSP70 interaction site [polypeptide binding]; other site
488538005172	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
488538005173	substrate binding site [polypeptide binding]; other site
488538005174	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
488538005175	Zn binding sites [ion binding]; other site
488538005176	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
488538005177	dimer interface [polypeptide binding]; other site
488538005178	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
488538005179	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
488538005180	nucleotide binding site [chemical binding]; other site
488538005181	GrpE; Region: GrpE; pfam01025
488538005182	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
488538005183	dimer interface [polypeptide binding]; other site
488538005184	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
488538005185	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
488538005186	ribonuclease PH; Reviewed; Region: rph; PRK00173
488538005187	Ribonuclease PH; Region: RNase_PH_bact; cd11362
488538005188	hexamer interface [polypeptide binding]; other site
488538005189	active site
488538005190	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
488538005191	active site
488538005192	dimerization interface [polypeptide binding]; other site
488538005193	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
488538005194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488538005195	FeS/SAM binding site; other site
488538005196	HemN C-terminal domain; Region: HemN_C; pfam06969
488538005197	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
488538005198	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
488538005199	putative ligand binding site [chemical binding]; other site
488538005200	Predicted methyltransferases [General function prediction only]; Region: COG0313
488538005201	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
488538005202	putative SAM binding site [chemical binding]; other site
488538005203	putative homodimer interface [polypeptide binding]; other site
488538005204	hypothetical protein; Reviewed; Region: PRK12497
488538005205	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
488538005206	BON domain; Region: BON; pfam04972
488538005207	BON domain; Region: BON; pfam04972
488538005208	glutathione synthetase; Provisional; Region: PRK05246
488538005209	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
488538005210	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
488538005211	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
488538005212	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
488538005213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538005214	Walker A motif; other site
488538005215	ATP binding site [chemical binding]; other site
488538005216	Walker B motif; other site
488538005217	arginine finger; other site
488538005218	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
488538005219	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
488538005220	nucleotide binding site/active site [active]
488538005221	HIT family signature motif; other site
488538005222	catalytic residue [active]
488538005223	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488538005224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488538005225	Coenzyme A binding pocket [chemical binding]; other site
488538005226	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488538005227	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538005228	non-specific DNA binding site [nucleotide binding]; other site
488538005229	salt bridge; other site
488538005230	sequence-specific DNA binding site [nucleotide binding]; other site
488538005231	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
488538005232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
488538005233	Smr domain; Region: Smr; pfam01713
488538005234	Tim44-like domain; Region: Tim44; pfam04280
488538005235	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
488538005236	preprotein translocase subunit SecB; Validated; Region: PRK05751
488538005237	SecA binding site; other site
488538005238	Preprotein binding site; other site
488538005239	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
488538005240	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
488538005241	active site
488538005242	catalytic site [active]
488538005243	substrate binding site [chemical binding]; other site
488538005244	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
488538005245	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
488538005246	CoA-binding site [chemical binding]; other site
488538005247	ATP-binding [chemical binding]; other site
488538005248	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
488538005249	active site
488538005250	dimer interface [polypeptide binding]; other site
488538005251	PEP synthetase regulatory protein; Provisional; Region: PRK05339
488538005252	uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115
488538005253	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
488538005254	transcription termination factor Rho; Provisional; Region: rho; PRK09376
488538005255	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
488538005256	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
488538005257	RNA binding site [nucleotide binding]; other site
488538005258	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
488538005259	multimer interface [polypeptide binding]; other site
488538005260	Walker A motif; other site
488538005261	ATP binding site [chemical binding]; other site
488538005262	Walker B motif; other site
488538005263	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
488538005264	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
488538005265	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
488538005266	active site
488538005267	DNA binding site [nucleotide binding]
488538005268	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
488538005269	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
488538005270	trmE is a tRNA modification GTPase; Region: trmE; cd04164
488538005271	G1 box; other site
488538005272	GTP/Mg2+ binding site [chemical binding]; other site
488538005273	Switch I region; other site
488538005274	G2 box; other site
488538005275	Switch II region; other site
488538005276	G3 box; other site
488538005277	G4 box; other site
488538005278	G5 box; other site
488538005279	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
488538005280	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
488538005281	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
488538005282	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
488538005283	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
488538005284	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
488538005285	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
488538005286	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
488538005287	P-loop; other site
488538005288	Magnesium ion binding site [ion binding]; other site
488538005289	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
488538005290	ParB-like nuclease domain; Region: ParB; smart00470
488538005291	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
488538005292	Lipopolysaccharide-assembly; Region: LptE; cl01125
488538005293	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
488538005294	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
488538005295	HIGH motif; other site
488538005296	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
488538005297	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538005298	active site
488538005299	KMSKS motif; other site
488538005300	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
488538005301	tRNA binding surface [nucleotide binding]; other site
488538005302	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
488538005303	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
488538005304	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488538005305	catalytic residue [active]
488538005306	GTP cyclohydrolase; Provisional; Region: PRK08815
488538005307	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
488538005308	dimerization interface [polypeptide binding]; other site
488538005309	active site
488538005310	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488538005311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538005312	active site
488538005313	phosphorylation site [posttranslational modification]
488538005314	intermolecular recognition site; other site
488538005315	dimerization interface [polypeptide binding]; other site
488538005316	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538005317	DNA binding site [nucleotide binding]
488538005318	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
488538005319	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
488538005320	TPR repeat; Region: TPR_11; pfam13414
488538005321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005322	binding surface
488538005323	TPR motif; other site
488538005324	TPR repeat; Region: TPR_11; pfam13414
488538005325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005326	binding surface
488538005327	TPR motif; other site
488538005328	TPR repeat; Region: TPR_11; pfam13414
488538005329	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
488538005330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
488538005331	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
488538005332	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
488538005333	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
488538005334	Fe-S cluster binding site [ion binding]; other site
488538005335	active site
488538005336	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
488538005337	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
488538005338	N-acetyl-D-glucosamine binding site [chemical binding]; other site
488538005339	catalytic residue [active]
488538005340	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
488538005341	MPT binding site; other site
488538005342	trimer interface [polypeptide binding]; other site
488538005343	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
488538005344	RNA/DNA hybrid binding site [nucleotide binding]; other site
488538005345	active site
488538005346	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
488538005347	DNA methylase; Region: N6_N4_Mtase; pfam01555
488538005348	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538005349	active site
488538005350	malate synthase G; Provisional; Region: PRK02999
488538005351	active site
488538005352	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
488538005353	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
488538005354	active site
488538005355	substrate binding site [chemical binding]; other site
488538005356	metal binding site [ion binding]; metal-binding site
488538005357	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
488538005358	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
488538005359	active site
488538005360	tetramer interface; other site
488538005361	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
488538005362	dimer interface [polypeptide binding]; other site
488538005363	active site
488538005364	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
488538005365	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
488538005366	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
488538005367	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
488538005368	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488538005369	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
488538005370	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
488538005371	classical (c) SDRs; Region: SDR_c; cd05233
488538005372	NAD(P) binding site [chemical binding]; other site
488538005373	active site
488538005374	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
488538005375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538005376	NAD(P) binding site [chemical binding]; other site
488538005377	active site
488538005378	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
488538005379	tartrate dehydrogenase; Region: TTC; TIGR02089
488538005380	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
488538005381	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
488538005382	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
488538005383	N-acetyl-D-glucosamine binding site [chemical binding]; other site
488538005384	catalytic residue [active]
488538005385	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
488538005386	Peptidase family M48; Region: Peptidase_M48; cl12018
488538005387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005388	TPR motif; other site
488538005389	TPR repeat; Region: TPR_11; pfam13414
488538005390	binding surface
488538005391	TPR repeat; Region: TPR_11; pfam13414
488538005392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005393	binding surface
488538005394	TPR motif; other site
488538005395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005396	binding surface
488538005397	TPR repeat; Region: TPR_11; pfam13414
488538005398	TPR motif; other site
488538005399	TPR repeat; Region: TPR_11; pfam13414
488538005400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005401	TPR motif; other site
488538005402	TPR repeat; Region: TPR_11; pfam13414
488538005403	binding surface
488538005404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005405	binding surface
488538005406	TPR motif; other site
488538005407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005408	binding surface
488538005409	Tetratricopeptide repeat; Region: TPR_16; pfam13432
488538005410	TPR motif; other site
488538005411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538005412	non-specific DNA binding site [nucleotide binding]; other site
488538005413	salt bridge; other site
488538005414	sequence-specific DNA binding site [nucleotide binding]; other site
488538005415	Cupin domain; Region: Cupin_2; pfam07883
488538005416	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
488538005417	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
488538005418	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
488538005419	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
488538005420	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
488538005421	active site
488538005422	FMN binding site [chemical binding]; other site
488538005423	substrate binding site [chemical binding]; other site
488538005424	3Fe-4S cluster binding site [ion binding]; other site
488538005425	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
488538005426	domain_subunit interface; other site
488538005427	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
488538005428	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
488538005429	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
488538005430	putative active site [active]
488538005431	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
488538005432	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
488538005433	Amidase; Region: Amidase; cl11426
488538005434	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
488538005435	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
488538005436	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
488538005437	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
488538005438	hydrophobic ligand binding site; other site
488538005439	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538005440	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
488538005441	NAD(P) binding site [chemical binding]; other site
488538005442	catalytic residues [active]
488538005443	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
488538005444	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
488538005445	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
488538005446	FMN-binding pocket [chemical binding]; other site
488538005447	flavin binding motif; other site
488538005448	phosphate binding motif [ion binding]; other site
488538005449	beta-alpha-beta structure motif; other site
488538005450	NAD binding pocket [chemical binding]; other site
488538005451	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538005452	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
488538005453	catalytic loop [active]
488538005454	iron binding site [ion binding]; other site
488538005455	EamA-like transporter family; Region: EamA; cl17759
488538005456	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538005457	short chain dehydrogenase; Provisional; Region: PRK07577
488538005458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538005459	NAD(P) binding site [chemical binding]; other site
488538005460	active site
488538005461	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
488538005462	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
488538005463	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
488538005464	alpha subunit interface [polypeptide binding]; other site
488538005465	active site
488538005466	substrate binding site [chemical binding]; other site
488538005467	Fe binding site [ion binding]; other site
488538005468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538005469	dimer interface [polypeptide binding]; other site
488538005470	conserved gate region; other site
488538005471	putative PBP binding loops; other site
488538005472	ABC-ATPase subunit interface; other site
488538005473	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488538005474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538005475	dimer interface [polypeptide binding]; other site
488538005476	conserved gate region; other site
488538005477	putative PBP binding loops; other site
488538005478	ABC-ATPase subunit interface; other site
488538005479	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
488538005480	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
488538005481	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488538005482	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538005483	Walker A/P-loop; other site
488538005484	ATP binding site [chemical binding]; other site
488538005485	Q-loop/lid; other site
488538005486	ABC transporter signature motif; other site
488538005487	Walker B; other site
488538005488	D-loop; other site
488538005489	H-loop/switch region; other site
488538005490	TOBE domain; Region: TOBE_2; pfam08402
488538005491	Domain of unknown function (DUF336); Region: DUF336; cl01249
488538005492	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
488538005493	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
488538005494	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
488538005495	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
488538005496	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
488538005497	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
488538005498	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
488538005499	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
488538005500	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
488538005501	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
488538005502	putative [4Fe-4S] binding site [ion binding]; other site
488538005503	putative molybdopterin cofactor binding site [chemical binding]; other site
488538005504	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
488538005505	putative molybdopterin cofactor binding site; other site
488538005506	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
488538005507	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488538005508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538005509	dimer interface [polypeptide binding]; other site
488538005510	phosphorylation site [posttranslational modification]
488538005511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538005512	ATP binding site [chemical binding]; other site
488538005513	Mg2+ binding site [ion binding]; other site
488538005514	G-X-G motif; other site
488538005515	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488538005516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538005517	active site
488538005518	phosphorylation site [posttranslational modification]
488538005519	intermolecular recognition site; other site
488538005520	dimerization interface [polypeptide binding]; other site
488538005521	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538005522	DNA binding site [nucleotide binding]
488538005523	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
488538005524	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
488538005525	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
488538005526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
488538005527	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
488538005528	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
488538005529	dimerization interface [polypeptide binding]; other site
488538005530	NAD binding site [chemical binding]; other site
488538005531	ligand binding site [chemical binding]; other site
488538005532	catalytic site [active]
488538005533	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
488538005534	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
488538005535	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
488538005536	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
488538005537	Transcriptional regulators [Transcription]; Region: FadR; COG2186
488538005538	FCD domain; Region: FCD; pfam07729
488538005539	tricarballylate dehydrogenase; Validated; Region: PRK08274
488538005540	Predicted oxidoreductase [General function prediction only]; Region: COG3573
488538005541	tricarballylate utilization protein B; Provisional; Region: PRK15033
488538005542	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538005543	active site
488538005544	Int/Topo IB signature motif; other site
488538005545	DNA binding site [nucleotide binding]
488538005546	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538005547	active site
488538005548	Int/Topo IB signature motif; other site
488538005549	DNA binding site [nucleotide binding]
488538005550	Domain of unknown function DUF87; Region: DUF87; pfam01935
488538005551	HerA helicase [Replication, recombination, and repair]; Region: COG0433
488538005552	SIR2-like domain; Region: SIR2_2; pfam13289
488538005553	TrwC relaxase; Region: TrwC; pfam08751
488538005554	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
488538005555	AAA domain; Region: AAA_30; pfam13604
488538005556	Family description; Region: UvrD_C_2; pfam13538
488538005557	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
488538005558	Ca2+ binding site [ion binding]; other site
488538005559	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
488538005560	Ca2+ binding site [ion binding]; other site
488538005561	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
488538005562	Ca2+ binding site [ion binding]; other site
488538005563	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
488538005564	Ca2+ binding site [ion binding]; other site
488538005565	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
488538005566	Ca2+ binding site [ion binding]; other site
488538005567	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
488538005568	active site
488538005569	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538005570	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488538005571	TM-ABC transporter signature motif; other site
488538005572	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538005573	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488538005574	TM-ABC transporter signature motif; other site
488538005575	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488538005576	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488538005577	Walker A/P-loop; other site
488538005578	ATP binding site [chemical binding]; other site
488538005579	Q-loop/lid; other site
488538005580	ABC transporter signature motif; other site
488538005581	Walker B; other site
488538005582	D-loop; other site
488538005583	H-loop/switch region; other site
488538005584	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538005585	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
488538005586	Walker A/P-loop; other site
488538005587	ATP binding site [chemical binding]; other site
488538005588	Q-loop/lid; other site
488538005589	ABC transporter signature motif; other site
488538005590	Walker B; other site
488538005591	D-loop; other site
488538005592	H-loop/switch region; other site
488538005593	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
488538005594	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
488538005595	ligand binding site [chemical binding]; other site
488538005596	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
488538005597	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
488538005598	active site
488538005599	Zn binding site [ion binding]; other site
488538005600	hypothetical protein; Provisional; Region: PRK07036
488538005601	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
488538005602	inhibitor-cofactor binding pocket; inhibition site
488538005603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538005604	catalytic residue [active]
488538005605	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
488538005606	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
488538005607	DNA binding residues [nucleotide binding]
488538005608	dimerization interface [polypeptide binding]; other site
488538005609	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
488538005610	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
488538005611	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538005612	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538005613	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
488538005614	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538005615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538005616	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
488538005617	putative substrate binding pocket [chemical binding]; other site
488538005618	dimerization interface [polypeptide binding]; other site
488538005619	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
488538005620	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
488538005621	putative ligand binding site [chemical binding]; other site
488538005622	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
488538005623	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
488538005624	Walker A/P-loop; other site
488538005625	ATP binding site [chemical binding]; other site
488538005626	Q-loop/lid; other site
488538005627	ABC transporter signature motif; other site
488538005628	Walker B; other site
488538005629	D-loop; other site
488538005630	H-loop/switch region; other site
488538005631	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
488538005632	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538005633	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
488538005634	TM-ABC transporter signature motif; other site
488538005635	Aspergillus nidulans lactam utilization protein LamB and similar proteins; Region: LamB_like; cd11665
488538005636	putative active site [active]
488538005637	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
488538005638	carboxyltransferase (CT) interaction site; other site
488538005639	biotinylation site [posttranslational modification]; other site
488538005640	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
488538005641	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488538005642	ATP-grasp domain; Region: ATP-grasp_4; cl17255
488538005643	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
488538005644	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
488538005645	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
488538005646	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
488538005647	BioY family; Region: BioY; pfam02632
488538005648	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
488538005649	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
488538005650	Cadherin repeat-like domain; Region: CA_like; cl15786
488538005651	PKD domain; Region: PKD; pfam00801
488538005652	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
488538005653	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
488538005654	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
488538005655	putative hydrophobic ligand binding site [chemical binding]; other site
488538005656	protein interface [polypeptide binding]; other site
488538005657	gate; other site
488538005658	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
488538005659	hypothetical protein; Provisional; Region: PRK02399
488538005660	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
488538005661	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488538005662	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488538005663	Walker A/P-loop; other site
488538005664	ATP binding site [chemical binding]; other site
488538005665	Q-loop/lid; other site
488538005666	ABC transporter signature motif; other site
488538005667	Walker B; other site
488538005668	D-loop; other site
488538005669	H-loop/switch region; other site
488538005670	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488538005671	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
488538005672	Walker A/P-loop; other site
488538005673	ATP binding site [chemical binding]; other site
488538005674	Q-loop/lid; other site
488538005675	ABC transporter signature motif; other site
488538005676	Walker B; other site
488538005677	D-loop; other site
488538005678	H-loop/switch region; other site
488538005679	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
488538005680	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
488538005681	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538005682	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488538005683	TM-ABC transporter signature motif; other site
488538005684	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488538005685	TM-ABC transporter signature motif; other site
488538005686	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
488538005687	Cupin domain; Region: Cupin_2; pfam07883
488538005688	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488538005689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538005690	dimer interface [polypeptide binding]; other site
488538005691	conserved gate region; other site
488538005692	putative PBP binding loops; other site
488538005693	ABC-ATPase subunit interface; other site
488538005694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538005695	dimer interface [polypeptide binding]; other site
488538005696	conserved gate region; other site
488538005697	putative PBP binding loops; other site
488538005698	ABC-ATPase subunit interface; other site
488538005699	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488538005700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538005701	Walker A/P-loop; other site
488538005702	ATP binding site [chemical binding]; other site
488538005703	Q-loop/lid; other site
488538005704	ABC transporter signature motif; other site
488538005705	Walker B; other site
488538005706	D-loop; other site
488538005707	H-loop/switch region; other site
488538005708	TOBE domain; Region: TOBE_2; pfam08402
488538005709	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
488538005710	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
488538005711	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
488538005712	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
488538005713	active site pocket [active]
488538005714	Protein of unknown function DUF262; Region: DUF262; pfam03235
488538005715	Uncharacterized conserved protein [Function unknown]; Region: COG1479
488538005716	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
488538005717	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
488538005718	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
488538005719	inhibitor-cofactor binding pocket; inhibition site
488538005720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538005721	catalytic residue [active]
488538005722	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538005723	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538005724	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
488538005725	putative deacylase active site [active]
488538005726	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
488538005727	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
488538005728	catalytic residues [active]
488538005729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538005730	TPR motif; other site
488538005731	binding surface
488538005732	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
488538005733	Uncharacterized conserved protein [Function unknown]; Region: COG2835
488538005734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
488538005735	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
488538005736	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538005737	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
488538005738	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488538005739	active site
488538005740	motif I; other site
488538005741	motif II; other site
488538005742	succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538
488538005743	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538005744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538005745	homodimer interface [polypeptide binding]; other site
488538005746	catalytic residue [active]
488538005747	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
488538005748	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
488538005749	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
488538005750	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
488538005751	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
488538005752	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
488538005753	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
488538005754	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
488538005755	dimer interface [polypeptide binding]; other site
488538005756	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
488538005757	active site
488538005758	Fe binding site [ion binding]; other site
488538005759	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
488538005760	putative catalytic site [active]
488538005761	putative phosphate binding site [ion binding]; other site
488538005762	active site
488538005763	metal binding site A [ion binding]; metal-binding site
488538005764	DNA binding site [nucleotide binding]
488538005765	putative AP binding site [nucleotide binding]; other site
488538005766	putative metal binding site B [ion binding]; other site
488538005767	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
488538005768	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
488538005769	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
488538005770	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
488538005771	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
488538005772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488538005773	FeS/SAM binding site; other site
488538005774	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
488538005775	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
488538005776	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
488538005777	Uncharacterized conserved protein [Function unknown]; Region: COG1434
488538005778	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
488538005779	putative active site [active]
488538005780	signal recognition particle protein; Provisional; Region: PRK10867
488538005781	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
488538005782	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
488538005783	P loop; other site
488538005784	GTP binding site [chemical binding]; other site
488538005785	Signal peptide binding domain; Region: SRP_SPB; pfam02978
488538005786	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
488538005787	RimM N-terminal domain; Region: RimM; pfam01782
488538005788	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
488538005789	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
488538005790	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
488538005791	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
488538005792	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
488538005793	substrate binding site [chemical binding]; other site
488538005794	ligand binding site [chemical binding]; other site
488538005795	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
488538005796	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
488538005797	substrate binding site [chemical binding]; other site
488538005798	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
488538005799	tartrate dehydrogenase; Region: TTC; TIGR02089
488538005800	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
488538005801	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
488538005802	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
488538005803	dimer interface [polypeptide binding]; other site
488538005804	pyridoxal binding site [chemical binding]; other site
488538005805	ATP binding site [chemical binding]; other site
488538005806	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
488538005807	Iron-sulfur protein interface; other site
488538005808	proximal quinone binding site [chemical binding]; other site
488538005809	SdhD (CybS) interface [polypeptide binding]; other site
488538005810	proximal heme binding site [chemical binding]; other site
488538005811	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
488538005812	putative SdhC subunit interface [polypeptide binding]; other site
488538005813	putative proximal heme binding site [chemical binding]; other site
488538005814	putative Iron-sulfur protein interface [polypeptide binding]; other site
488538005815	putative proximal quinone binding site; other site
488538005816	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
488538005817	L-aspartate oxidase; Provisional; Region: PRK06175
488538005818	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
488538005819	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
488538005820	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
488538005821	Predicted ATPase [General function prediction only]; Region: COG1485
488538005822	malate dehydrogenase; Reviewed; Region: PRK06223
488538005823	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
488538005824	NAD(P) binding site [chemical binding]; other site
488538005825	dimer interface [polypeptide binding]; other site
488538005826	tetramer (dimer of dimers) interface [polypeptide binding]; other site
488538005827	substrate binding site [chemical binding]; other site
488538005828	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
488538005829	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
488538005830	CoA-ligase; Region: Ligase_CoA; pfam00549
488538005831	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
488538005832	CoA binding domain; Region: CoA_binding; pfam02629
488538005833	CoA-ligase; Region: Ligase_CoA; pfam00549
488538005834	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
488538005835	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
488538005836	TPP-binding site [chemical binding]; other site
488538005837	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
488538005838	dimer interface [polypeptide binding]; other site
488538005839	PYR/PP interface [polypeptide binding]; other site
488538005840	TPP binding site [chemical binding]; other site
488538005841	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
488538005842	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
488538005843	E3 interaction surface; other site
488538005844	lipoyl attachment site [posttranslational modification]; other site
488538005845	e3 binding domain; Region: E3_binding; pfam02817
488538005846	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
488538005847	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
488538005848	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538005849	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538005850	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488538005851	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
488538005852	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538005853	active site
488538005854	DNA binding site [nucleotide binding]
488538005855	Int/Topo IB signature motif; other site
488538005856	Protein of unknown function, DUF484; Region: DUF484; cl17449
488538005857	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
488538005858	active site
488538005859	intersubunit interactions; other site
488538005860	catalytic residue [active]
488538005861	primosome assembly protein PriA; Validated; Region: PRK05580
488538005862	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488538005863	ATP binding site [chemical binding]; other site
488538005864	putative Mg++ binding site [ion binding]; other site
488538005865	Prokaryotic RING finger family 2; Region: Prok-RING_2; pfam14445
488538005866	helicase superfamily c-terminal domain; Region: HELICc; smart00490
488538005867	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
488538005868	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
488538005869	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
488538005870	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
488538005871	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
488538005872	beta subunit interaction interface [polypeptide binding]; other site
488538005873	Walker A motif; other site
488538005874	ATP binding site [chemical binding]; other site
488538005875	Walker B motif; other site
488538005876	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
488538005877	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
488538005878	core domain interface [polypeptide binding]; other site
488538005879	delta subunit interface [polypeptide binding]; other site
488538005880	epsilon subunit interface [polypeptide binding]; other site
488538005881	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
488538005882	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
488538005883	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
488538005884	alpha subunit interaction interface [polypeptide binding]; other site
488538005885	Walker A motif; other site
488538005886	ATP binding site [chemical binding]; other site
488538005887	Walker B motif; other site
488538005888	inhibitor binding site; inhibition site
488538005889	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
488538005890	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736
488538005891	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
488538005892	gamma subunit interface [polypeptide binding]; other site
488538005893	epsilon subunit interface [polypeptide binding]; other site
488538005894	LBP interface [polypeptide binding]; other site
488538005895	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
488538005896	putative active site [active]
488538005897	Ap4A binding site [chemical binding]; other site
488538005898	nudix motif; other site
488538005899	putative metal binding site [ion binding]; other site
488538005900	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
488538005901	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
488538005902	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
488538005903	protein binding site [polypeptide binding]; other site
488538005904	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
488538005905	Catalytic dyad [active]
488538005906	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
488538005907	phosphoglyceromutase; Provisional; Region: PRK05434
488538005908	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
488538005909	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
488538005910	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
488538005911	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
488538005912	active site
488538005913	(T/H)XGH motif; other site
488538005914	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
488538005915	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
488538005916	putative catalytic cysteine [active]
488538005917	gamma-glutamyl kinase; Provisional; Region: PRK05429
488538005918	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
488538005919	nucleotide binding site [chemical binding]; other site
488538005920	homotetrameric interface [polypeptide binding]; other site
488538005921	putative phosphate binding site [ion binding]; other site
488538005922	putative allosteric binding site; other site
488538005923	PUA domain; Region: PUA; pfam01472
488538005924	GTPase CgtA; Reviewed; Region: obgE; PRK12299
488538005925	GTP1/OBG; Region: GTP1_OBG; pfam01018
488538005926	Obg GTPase; Region: Obg; cd01898
488538005927	G1 box; other site
488538005928	GTP/Mg2+ binding site [chemical binding]; other site
488538005929	Switch I region; other site
488538005930	G2 box; other site
488538005931	G3 box; other site
488538005932	Switch II region; other site
488538005933	G4 box; other site
488538005934	G5 box; other site
488538005935	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
488538005936	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
488538005937	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
488538005938	galactonate dehydratase; Provisional; Region: PRK14017
488538005939	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
488538005940	active site pocket [active]
488538005941	Electron transfer DM13; Region: DM13; pfam10517
488538005942	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
488538005943	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
488538005944	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
488538005945	Dihydroneopterin aldolase; Region: FolB; smart00905
488538005946	active site
488538005947	Methyltransferase domain; Region: Methyltransf_11; pfam08241
488538005948	Methyltransferase domain; Region: Methyltransf_23; pfam13489
488538005949	hypothetical protein; Provisional; Region: PRK06034
488538005950	Chorismate mutase type II; Region: CM_2; smart00830
488538005951	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
488538005952	prephenate dehydrogenase; Validated; Region: PRK08507
488538005953	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
488538005954	putative active site [active]
488538005955	diaminopimelate decarboxylase; Region: lysA; TIGR01048
488538005956	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
488538005957	active site
488538005958	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488538005959	substrate binding site [chemical binding]; other site
488538005960	catalytic residues [active]
488538005961	dimer interface [polypeptide binding]; other site
488538005962	argininosuccinate lyase; Provisional; Region: PRK00855
488538005963	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
488538005964	active sites [active]
488538005965	tetramer interface [polypeptide binding]; other site
488538005966	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
488538005967	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
488538005968	catalytic residues [active]
488538005969	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
488538005970	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
488538005971	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
488538005972	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
488538005973	Ligand binding site [chemical binding]; other site
488538005974	Electron transfer flavoprotein domain; Region: ETF; pfam01012
488538005975	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
488538005976	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
488538005977	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
488538005978	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
488538005979	homodimer interface [polypeptide binding]; other site
488538005980	NADP binding site [chemical binding]; other site
488538005981	substrate binding site [chemical binding]; other site
488538005982	YGGT family; Region: YGGT; pfam02325
488538005983	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
488538005984	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
488538005985	Cu(I) binding site [ion binding]; other site
488538005986	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
488538005987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538005988	active site
488538005989	phosphorylation site [posttranslational modification]
488538005990	intermolecular recognition site; other site
488538005991	dimerization interface [polypeptide binding]; other site
488538005992	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
488538005993	DNA binding residues [nucleotide binding]
488538005994	dimerization interface [polypeptide binding]; other site
488538005995	acetyl-CoA synthetase; Provisional; Region: PRK00174
488538005996	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
488538005997	active site
488538005998	CoA binding site [chemical binding]; other site
488538005999	acyl-activating enzyme (AAE) consensus motif; other site
488538006000	AMP binding site [chemical binding]; other site
488538006001	acetate binding site [chemical binding]; other site
488538006002	RecX family; Region: RecX; cl00936
488538006003	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
488538006004	ABC-2 type transporter; Region: ABC2_membrane; cl17235
488538006005	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
488538006006	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
488538006007	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
488538006008	trimer interface [polypeptide binding]; other site
488538006009	active site
488538006010	acetylornithine aminotransferase; Provisional; Region: PRK02627
488538006011	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
488538006012	inhibitor-cofactor binding pocket; inhibition site
488538006013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538006014	catalytic residue [active]
488538006015	ornithine carbamoyltransferase; Provisional; Region: PRK00779
488538006016	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
488538006017	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
488538006018	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
488538006019	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
488538006020	dimerization interface [polypeptide binding]; other site
488538006021	domain crossover interface; other site
488538006022	redox-dependent activation switch; other site
488538006023	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
488538006024	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
488538006025	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
488538006026	conserved cys residue [active]
488538006027	methionine synthase I; Validated; Region: PRK07534
488538006028	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
488538006029	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
488538006030	dimer interface [polypeptide binding]; other site
488538006031	anticodon binding site; other site
488538006032	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
488538006033	homodimer interface [polypeptide binding]; other site
488538006034	motif 1; other site
488538006035	active site
488538006036	motif 2; other site
488538006037	GAD domain; Region: GAD; pfam02938
488538006038	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
488538006039	active site
488538006040	motif 3; other site
488538006041	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
488538006042	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
488538006043	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
488538006044	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
488538006045	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
488538006046	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
488538006047	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
488538006048	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
488538006049	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
488538006050	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
488538006051	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
488538006052	oligomerisation interface [polypeptide binding]; other site
488538006053	mobile loop; other site
488538006054	roof hairpin; other site
488538006055	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
488538006056	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
488538006057	ring oligomerisation interface [polypeptide binding]; other site
488538006058	ATP/Mg binding site [chemical binding]; other site
488538006059	stacking interactions; other site
488538006060	hinge regions; other site
488538006061	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
488538006062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538006063	non-specific DNA binding site [nucleotide binding]; other site
488538006064	salt bridge; other site
488538006065	sequence-specific DNA binding site [nucleotide binding]; other site
488538006066	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
488538006067	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
488538006068	ATP binding site [chemical binding]; other site
488538006069	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
488538006070	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
488538006071	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488538006072	active site
488538006073	nucleotide binding site [chemical binding]; other site
488538006074	HIGH motif; other site
488538006075	KMSKS motif; other site
488538006076	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
488538006077	quinone interaction residues [chemical binding]; other site
488538006078	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
488538006079	active site
488538006080	catalytic residues [active]
488538006081	FMN binding site [chemical binding]; other site
488538006082	substrate binding site [chemical binding]; other site
488538006083	Ribbon-helix-helix domain; Region: RHH_4; cl01775
488538006084	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
488538006085	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
488538006086	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
488538006087	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
488538006088	metal ion-dependent adhesion site (MIDAS); other site
488538006089	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
488538006090	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
488538006091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
488538006092	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
488538006093	HSP70 interaction site [polypeptide binding]; other site
488538006094	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
488538006095	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
488538006096	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
488538006097	Domain of unknown function DUF21; Region: DUF21; pfam01595
488538006098	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
488538006099	Transporter associated domain; Region: CorC_HlyC; smart01091
488538006100	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
488538006101	active site
488538006102	dimer interface [polypeptide binding]; other site
488538006103	metal binding site [ion binding]; metal-binding site
488538006104	shikimate kinase; Provisional; Region: PRK13946
488538006105	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
488538006106	ADP binding site [chemical binding]; other site
488538006107	magnesium binding site [ion binding]; other site
488538006108	putative shikimate binding site; other site
488538006109	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
488538006110	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488538006111	active site
488538006112	DNA binding site [nucleotide binding]
488538006113	Int/Topo IB signature motif; other site
488538006114	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
488538006115	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
488538006116	nitrilase; Region: PLN02798
488538006117	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
488538006118	putative active site [active]
488538006119	catalytic triad [active]
488538006120	dimer interface [polypeptide binding]; other site
488538006121	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
488538006122	GSH binding site [chemical binding]; other site
488538006123	catalytic residues [active]
488538006124	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
488538006125	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538006126	active site
488538006127	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
488538006128	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538006129	S-adenosylmethionine binding site [chemical binding]; other site
488538006130	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
488538006131	active site
488538006132	8-oxo-dGMP binding site [chemical binding]; other site
488538006133	nudix motif; other site
488538006134	metal binding site [ion binding]; metal-binding site
488538006135	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
488538006136	heterotetramer interface [polypeptide binding]; other site
488538006137	active site pocket [active]
488538006138	cleavage site
488538006139	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
488538006140	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
488538006141	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
488538006142	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
488538006143	SEC-C motif; Region: SEC-C; pfam02810
488538006144	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
488538006145	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
488538006146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538006147	S-adenosylmethionine binding site [chemical binding]; other site
488538006148	aspartate kinase; Reviewed; Region: PRK06635
488538006149	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
488538006150	putative nucleotide binding site [chemical binding]; other site
488538006151	putative catalytic residues [active]
488538006152	putative Mg ion binding site [ion binding]; other site
488538006153	putative aspartate binding site [chemical binding]; other site
488538006154	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
488538006155	putative allosteric regulatory site; other site
488538006156	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
488538006157	putative allosteric regulatory residue; other site
488538006158	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
488538006159	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538006160	non-specific DNA binding site [nucleotide binding]; other site
488538006161	salt bridge; other site
488538006162	sequence-specific DNA binding site [nucleotide binding]; other site
488538006163	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
488538006164	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
488538006165	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
488538006166	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
488538006167	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
488538006168	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
488538006169	dimer interface [polypeptide binding]; other site
488538006170	motif 1; other site
488538006171	active site
488538006172	motif 2; other site
488538006173	motif 3; other site
488538006174	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
488538006175	anticodon binding site; other site
488538006176	peptide chain release factor 1; Validated; Region: prfA; PRK00591
488538006177	This domain is found in peptide chain release factors; Region: PCRF; smart00937
488538006178	RF-1 domain; Region: RF-1; pfam00472
488538006179	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
488538006180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538006181	S-adenosylmethionine binding site [chemical binding]; other site
488538006182	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
488538006183	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
488538006184	MOSC domain; Region: MOSC; pfam03473
488538006185	putative peptidase; Provisional; Region: PRK11649
488538006186	Peptidase family M23; Region: Peptidase_M23; pfam01551
488538006187	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
488538006188	sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846
488538006189	Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372
488538006190	TPP-binding site; other site
488538006191	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538006192	PYR/PP interface [polypeptide binding]; other site
488538006193	dimer interface [polypeptide binding]; other site
488538006194	TPP binding site [chemical binding]; other site
488538006195	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
488538006196	aromatic arch; other site
488538006197	DCoH dimer interaction site [polypeptide binding]; other site
488538006198	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
488538006199	DCoH tetramer interaction site [polypeptide binding]; other site
488538006200	substrate binding site [chemical binding]; other site
488538006201	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
488538006202	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
488538006203	putative NAD(P) binding site [chemical binding]; other site
488538006204	active site
488538006205	putative substrate binding site [chemical binding]; other site
488538006206	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
488538006207	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
488538006208	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
488538006209	short chain dehydrogenase; Provisional; Region: PRK05993
488538006210	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
488538006211	NADP binding site [chemical binding]; other site
488538006212	active site
488538006213	steroid binding site; other site
488538006214	Cupin domain; Region: Cupin_2; cl17218
488538006215	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
488538006216	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
488538006217	Mg++ binding site [ion binding]; other site
488538006218	putative catalytic motif [active]
488538006219	O-Antigen ligase; Region: Wzy_C; cl04850
488538006220	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
488538006221	putative DNA binding site [nucleotide binding]; other site
488538006222	putative Zn2+ binding site [ion binding]; other site
488538006223	transcriptional activator RfaH; Region: RfaH; TIGR01955
488538006224	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
488538006225	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
488538006226	heterodimer interface [polypeptide binding]; other site
488538006227	homodimer interface [polypeptide binding]; other site
488538006228	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
488538006229	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
488538006230	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
488538006231	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
488538006232	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488538006233	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488538006234	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538006235	Walker A/P-loop; other site
488538006236	ATP binding site [chemical binding]; other site
488538006237	Q-loop/lid; other site
488538006238	ABC transporter signature motif; other site
488538006239	Walker B; other site
488538006240	D-loop; other site
488538006241	H-loop/switch region; other site
488538006242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
488538006243	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
488538006244	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
488538006245	active site
488538006246	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
488538006247	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538006248	putative ADP-binding pocket [chemical binding]; other site
488538006249	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
488538006250	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538006251	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
488538006252	putative ADP-binding pocket [chemical binding]; other site
488538006253	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
488538006254	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
488538006255	NADP binding site [chemical binding]; other site
488538006256	active site
488538006257	putative substrate binding site [chemical binding]; other site
488538006258	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
488538006259	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
488538006260	NADP-binding site; other site
488538006261	homotetramer interface [polypeptide binding]; other site
488538006262	substrate binding site [chemical binding]; other site
488538006263	homodimer interface [polypeptide binding]; other site
488538006264	active site
488538006265	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
488538006266	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
488538006267	active site
488538006268	dimer interface [polypeptide binding]; other site
488538006269	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
488538006270	Ligand Binding Site [chemical binding]; other site
488538006271	Molecular Tunnel; other site
488538006272	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
488538006273	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538006274	putative ADP-binding pocket [chemical binding]; other site
488538006275	Bacterial sugar transferase; Region: Bac_transf; pfam02397
488538006276	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
488538006277	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
488538006278	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
488538006279	NAD(P) binding site [chemical binding]; other site
488538006280	homodimer interface [polypeptide binding]; other site
488538006281	substrate binding site [chemical binding]; other site
488538006282	active site
488538006283	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
488538006284	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
488538006285	Substrate binding site; other site
488538006286	Cupin domain; Region: Cupin_2; cl17218
488538006287	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
488538006288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538006289	dimer interface [polypeptide binding]; other site
488538006290	conserved gate region; other site
488538006291	putative PBP binding loops; other site
488538006292	ABC-ATPase subunit interface; other site
488538006293	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
488538006294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538006295	Walker A/P-loop; other site
488538006296	ATP binding site [chemical binding]; other site
488538006297	Q-loop/lid; other site
488538006298	ABC transporter signature motif; other site
488538006299	Walker B; other site
488538006300	D-loop; other site
488538006301	H-loop/switch region; other site
488538006302	Putative transcription activator [Transcription]; Region: TenA; COG0819
488538006303	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
488538006304	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
488538006305	NMT1/THI5 like; Region: NMT1; pfam09084
488538006306	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
488538006307	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
488538006308	ATP binding site [chemical binding]; other site
488538006309	substrate interface [chemical binding]; other site
488538006310	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
488538006311	active site
488538006312	thiamine phosphate binding site [chemical binding]; other site
488538006313	pyrophosphate binding site [ion binding]; other site
488538006314	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
488538006315	ThiS interaction site; other site
488538006316	putative active site [active]
488538006317	tetramer interface [polypeptide binding]; other site
488538006318	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
488538006319	thiS-thiF/thiG interaction site; other site
488538006320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
488538006321	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
488538006322	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
488538006323	dimer interface [polypeptide binding]; other site
488538006324	substrate binding site [chemical binding]; other site
488538006325	ATP binding site [chemical binding]; other site
488538006326	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
488538006327	GAF domain; Region: GAF; pfam01590
488538006328	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538006329	DNA polymerase IV; Provisional; Region: PRK02794
488538006330	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
488538006331	active site
488538006332	DNA binding site [nucleotide binding]
488538006333	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
488538006334	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
488538006335	FAD binding site [chemical binding]; other site
488538006336	substrate binding pocket [chemical binding]; other site
488538006337	catalytic base [active]
488538006338	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
488538006339	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
488538006340	Ligand binding site; other site
488538006341	metal-binding site
488538006342	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
488538006343	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
488538006344	XdhC Rossmann domain; Region: XdhC_C; pfam13478
488538006345	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
488538006346	putative hydrophobic ligand binding site [chemical binding]; other site
488538006347	glucokinase; Provisional; Region: glk; PRK00292
488538006348	glucokinase, proteobacterial type; Region: glk; TIGR00749
488538006349	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
488538006350	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
488538006351	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
488538006352	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
488538006353	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
488538006354	putative active site [active]
488538006355	phosphogluconate dehydratase; Validated; Region: PRK09054
488538006356	6-phosphogluconate dehydratase; Region: edd; TIGR01196
488538006357	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
488538006358	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
488538006359	active site
488538006360	intersubunit interface [polypeptide binding]; other site
488538006361	catalytic residue [active]
488538006362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
488538006363	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538006364	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488538006365	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488538006366	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
488538006367	exopolyphosphatase; Region: exo_poly_only; TIGR03706
488538006368	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
488538006369	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
488538006370	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
488538006371	Low molecular weight phosphatase family; Region: LMWPc; cd00115
488538006372	active site
488538006373	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
488538006374	amphipathic channel; other site
488538006375	Asn-Pro-Ala signature motifs; other site
488538006376	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
488538006377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538006378	putative substrate translocation pore; other site
488538006379	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
488538006380	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
488538006381	G1 box; other site
488538006382	putative GEF interaction site [polypeptide binding]; other site
488538006383	GTP/Mg2+ binding site [chemical binding]; other site
488538006384	Switch I region; other site
488538006385	G2 box; other site
488538006386	G3 box; other site
488538006387	Switch II region; other site
488538006388	G4 box; other site
488538006389	G5 box; other site
488538006390	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
488538006391	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
488538006392	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
488538006393	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
488538006394	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538006395	active site
488538006396	choline dehydrogenase; Validated; Region: PRK02106
488538006397	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
488538006398	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
488538006399	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
488538006400	HlyD family secretion protein; Region: HlyD_3; pfam13437
488538006401	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
488538006402	amidase; Provisional; Region: PRK07056
488538006403	Amidase; Region: Amidase; cl11426
488538006404	choline dehydrogenase; Validated; Region: PRK02106
488538006405	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
488538006406	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
488538006407	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
488538006408	substrate binding site [chemical binding]; other site
488538006409	catalytic Zn binding site [ion binding]; other site
488538006410	NAD binding site [chemical binding]; other site
488538006411	structural Zn binding site [ion binding]; other site
488538006412	dimer interface [polypeptide binding]; other site
488538006413	S-formylglutathione hydrolase; Region: PLN02442
488538006414	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
488538006415	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
488538006416	agmatinase; Region: agmatinase; TIGR01230
488538006417	oligomer interface [polypeptide binding]; other site
488538006418	putative active site [active]
488538006419	Mn binding site [ion binding]; other site
488538006420	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
488538006421	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488538006422	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
488538006423	active site
488538006424	acetylornithine deacetylase; Provisional; Region: PRK07522
488538006425	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
488538006426	metal binding site [ion binding]; metal-binding site
488538006427	putative dimer interface [polypeptide binding]; other site
488538006428	EamA-like transporter family; Region: EamA; pfam00892
488538006429	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538006430	EamA-like transporter family; Region: EamA; pfam00892
488538006431	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
488538006432	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
488538006433	substrate binding site [chemical binding]; other site
488538006434	hexamer interface [polypeptide binding]; other site
488538006435	metal binding site [ion binding]; metal-binding site
488538006436	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
488538006437	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
488538006438	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
488538006439	putative dimer interface [polypeptide binding]; other site
488538006440	N-terminal domain interface [polypeptide binding]; other site
488538006441	putative substrate binding pocket (H-site) [chemical binding]; other site
488538006442	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
488538006443	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
488538006444	active site residue [active]
488538006445	Isochorismatase family; Region: Isochorismatase; pfam00857
488538006446	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
488538006447	catalytic triad [active]
488538006448	metal binding site [ion binding]; metal-binding site
488538006449	conserved cis-peptide bond; other site
488538006450	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538006451	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
488538006452	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
488538006453	inhibitor-cofactor binding pocket; inhibition site
488538006454	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538006455	catalytic residue [active]
488538006456	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
488538006457	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488538006458	DNA-binding site [nucleotide binding]; DNA binding site
488538006459	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538006460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538006461	homodimer interface [polypeptide binding]; other site
488538006462	catalytic residue [active]
488538006463	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
488538006464	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
488538006465	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
488538006466	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
488538006467	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
488538006468	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
488538006469	homodimer interface [polypeptide binding]; other site
488538006470	NADP binding site [chemical binding]; other site
488538006471	substrate binding site [chemical binding]; other site
488538006472	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
488538006473	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538006474	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
488538006475	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
488538006476	active site
488538006477	catalytic site [active]
488538006478	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
488538006479	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
488538006480	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
488538006481	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
488538006482	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488538006483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538006484	Walker A/P-loop; other site
488538006485	ATP binding site [chemical binding]; other site
488538006486	Q-loop/lid; other site
488538006487	ABC transporter signature motif; other site
488538006488	Walker B; other site
488538006489	D-loop; other site
488538006490	H-loop/switch region; other site
488538006491	TOBE domain; Region: TOBE_2; pfam08402
488538006492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538006493	dimer interface [polypeptide binding]; other site
488538006494	conserved gate region; other site
488538006495	putative PBP binding loops; other site
488538006496	ABC-ATPase subunit interface; other site
488538006497	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488538006498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538006499	dimer interface [polypeptide binding]; other site
488538006500	conserved gate region; other site
488538006501	putative PBP binding loops; other site
488538006502	ABC-ATPase subunit interface; other site
488538006503	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
488538006504	oligomer interface [polypeptide binding]; other site
488538006505	putative active site [active]
488538006506	Mn binding site [ion binding]; other site
488538006507	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
488538006508	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538006509	putative aminotransferase; Validated; Region: PRK07480
488538006510	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
488538006511	inhibitor-cofactor binding pocket; inhibition site
488538006512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538006513	catalytic residue [active]
488538006514	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
488538006515	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
488538006516	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
488538006517	active site
488538006518	substrate binding pocket [chemical binding]; other site
488538006519	dimer interface [polypeptide binding]; other site
488538006520	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538006521	EamA-like transporter family; Region: EamA; pfam00892
488538006522	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
488538006523	DNA photolyase; Region: DNA_photolyase; pfam00875
488538006524	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
488538006525	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
488538006526	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
488538006527	Intracellular septation protein A; Region: IspA; pfam04279
488538006528	C factor cell-cell signaling protein; Provisional; Region: PRK09009
488538006529	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
488538006530	NADP binding site [chemical binding]; other site
488538006531	homodimer interface [polypeptide binding]; other site
488538006532	active site
488538006533	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
488538006534	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488538006535	substrate binding site [chemical binding]; other site
488538006536	dimer interface [polypeptide binding]; other site
488538006537	ATP binding site [chemical binding]; other site
488538006538	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
488538006539	active site
488538006540	catalytic triad [active]
488538006541	oxyanion hole [active]
488538006542	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
488538006543	ligand binding site [chemical binding]; other site
488538006544	active site
488538006545	UGI interface [polypeptide binding]; other site
488538006546	catalytic site [active]
488538006547	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538006548	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538006549	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
488538006550	putative effector binding pocket; other site
488538006551	dimerization interface [polypeptide binding]; other site
488538006552	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
488538006553	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488538006554	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488538006555	ABC transporter; Region: ABC_tran_2; pfam12848
488538006556	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488538006557	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488538006558	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
488538006559	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
488538006560	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
488538006561	active site residue [active]
488538006562	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538006563	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538006564	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538006565	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
488538006566	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
488538006567	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538006568	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
488538006569	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
488538006570	DctM-like transporters; Region: DctM; pfam06808
488538006571	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
488538006572	Amidase; Region: Amidase; cl11426
488538006573	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
488538006574	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
488538006575	ligand binding site [chemical binding]; other site
488538006576	flexible hinge region; other site
488538006577	Protein of unknown function, DUF393; Region: DUF393; pfam04134
488538006578	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538006579	EamA-like transporter family; Region: EamA; pfam00892
488538006580	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488538006581	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488538006582	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
488538006583	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
488538006584	active site
488538006585	putative substrate binding pocket [chemical binding]; other site
488538006586	Methyltransferase domain; Region: Methyltransf_12; pfam08242
488538006587	Predicted amidohydrolase [General function prediction only]; Region: COG0388
488538006588	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
488538006589	active site
488538006590	catalytic triad [active]
488538006591	dimer interface [polypeptide binding]; other site
488538006592	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
488538006593	homotrimer interaction site [polypeptide binding]; other site
488538006594	putative active site [active]
488538006595	SlyX; Region: SlyX; pfam04102
488538006596	cystathionine beta-lyase; Provisional; Region: PRK07050
488538006597	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
488538006598	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538006599	catalytic residue [active]
488538006600	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
488538006601	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
488538006602	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
488538006603	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
488538006604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488538006605	dimerization interface [polypeptide binding]; other site
488538006606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538006607	dimer interface [polypeptide binding]; other site
488538006608	phosphorylation site [posttranslational modification]
488538006609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538006610	ATP binding site [chemical binding]; other site
488538006611	Mg2+ binding site [ion binding]; other site
488538006612	G-X-G motif; other site
488538006613	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488538006614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538006615	active site
488538006616	phosphorylation site [posttranslational modification]
488538006617	intermolecular recognition site; other site
488538006618	dimerization interface [polypeptide binding]; other site
488538006619	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538006620	DNA binding site [nucleotide binding]
488538006621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
488538006622	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
488538006623	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
488538006624	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
488538006625	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
488538006626	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
488538006627	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
488538006628	ligand binding site [chemical binding]; other site
488538006629	flexible hinge region; other site
488538006630	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
488538006631	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
488538006632	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
488538006633	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
488538006634	Cytochrome P450; Region: p450; cl12078
488538006635	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
488538006636	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
488538006637	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
488538006638	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
488538006639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538006640	Walker A/P-loop; other site
488538006641	ATP binding site [chemical binding]; other site
488538006642	Q-loop/lid; other site
488538006643	ABC transporter signature motif; other site
488538006644	Walker B; other site
488538006645	D-loop; other site
488538006646	H-loop/switch region; other site
488538006647	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
488538006648	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
488538006649	Walker A/P-loop; other site
488538006650	ATP binding site [chemical binding]; other site
488538006651	Q-loop/lid; other site
488538006652	ABC transporter signature motif; other site
488538006653	Walker B; other site
488538006654	D-loop; other site
488538006655	H-loop/switch region; other site
488538006656	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
488538006657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538006658	dimer interface [polypeptide binding]; other site
488538006659	conserved gate region; other site
488538006660	putative PBP binding loops; other site
488538006661	ABC-ATPase subunit interface; other site
488538006662	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
488538006663	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
488538006664	Walker A/P-loop; other site
488538006665	ATP binding site [chemical binding]; other site
488538006666	Q-loop/lid; other site
488538006667	ABC transporter signature motif; other site
488538006668	Walker B; other site
488538006669	D-loop; other site
488538006670	H-loop/switch region; other site
488538006671	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
488538006672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488538006673	dimer interface [polypeptide binding]; other site
488538006674	conserved gate region; other site
488538006675	putative PBP binding loops; other site
488538006676	ABC-ATPase subunit interface; other site
488538006677	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
488538006678	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
488538006679	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
488538006680	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
488538006681	[2Fe-2S] cluster binding site [ion binding]; other site
488538006682	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
488538006683	active site
488538006684	substrate binding site [chemical binding]; other site
488538006685	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
488538006686	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538006687	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538006688	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488538006689	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
488538006690	iron-sulfur cluster [ion binding]; other site
488538006691	[2Fe-2S] cluster binding site [ion binding]; other site
488538006692	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
488538006693	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
488538006694	molybdopterin cofactor binding site; other site
488538006695	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
488538006696	molybdopterin cofactor binding site; other site
488538006697	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
488538006698	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
488538006699	putative molybdopterin cofactor binding site; other site
488538006700	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
488538006701	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
488538006702	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
488538006703	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
488538006704	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
488538006705	alpha subunit interface [polypeptide binding]; other site
488538006706	active site
488538006707	substrate binding site [chemical binding]; other site
488538006708	Fe binding site [ion binding]; other site
488538006709	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538006710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538006711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
488538006712	dimerization interface [polypeptide binding]; other site
488538006713	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538006714	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
488538006715	oligomerization interface [polypeptide binding]; other site
488538006716	active site
488538006717	metal binding site [ion binding]; metal-binding site
488538006718	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
488538006719	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
488538006720	Potassium binding sites [ion binding]; other site
488538006721	Cesium cation binding sites [ion binding]; other site
488538006722	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
488538006723	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538006724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538006725	LysR substrate binding domain; Region: LysR_substrate; pfam03466
488538006726	dimerization interface [polypeptide binding]; other site
488538006727	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538006728	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
488538006729	NAD(P) binding site [chemical binding]; other site
488538006730	catalytic residues [active]
488538006731	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
488538006732	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
488538006733	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
488538006734	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
488538006735	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
488538006736	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488538006737	PYR/PP interface [polypeptide binding]; other site
488538006738	dimer interface [polypeptide binding]; other site
488538006739	TPP binding site [chemical binding]; other site
488538006740	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488538006741	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
488538006742	TPP-binding site [chemical binding]; other site
488538006743	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
488538006744	choline-sulfatase; Region: chol_sulfatase; TIGR03417
488538006745	Sulfatase; Region: Sulfatase; cl17466
488538006746	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
488538006747	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
488538006748	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
488538006749	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
488538006750	putative acyl-acceptor binding pocket; other site
488538006751	Helix-turn-helix domain; Region: HTH_18; pfam12833
488538006752	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036
488538006753	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
488538006754	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
488538006755	substrate binding pocket [chemical binding]; other site
488538006756	substrate-Mg2+ binding site; other site
488538006757	aspartate-rich region 1; other site
488538006758	aspartate-rich region 2; other site
488538006759	phytoene desaturase; Region: crtI_fam; TIGR02734
488538006760	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
488538006761	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
488538006762	active site lid residues [active]
488538006763	substrate binding pocket [chemical binding]; other site
488538006764	catalytic residues [active]
488538006765	substrate-Mg2+ binding site; other site
488538006766	aspartate-rich region 1; other site
488538006767	aspartate-rich region 2; other site
488538006768	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
488538006769	lycopene cyclase; Region: lycopene_cycl; TIGR01789
488538006770	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
488538006771	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
488538006772	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
488538006773	homotetramer interface [polypeptide binding]; other site
488538006774	FMN binding site [chemical binding]; other site
488538006775	homodimer contacts [polypeptide binding]; other site
488538006776	putative active site [active]
488538006777	putative substrate binding site [chemical binding]; other site
488538006778	Transcriptional regulator [Transcription]; Region: IclR; COG1414
488538006779	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
488538006780	Bacterial transcriptional regulator; Region: IclR; pfam01614
488538006781	choline dehydrogenase; Validated; Region: PRK02106
488538006782	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
488538006783	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
488538006784	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
488538006785	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
488538006786	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
488538006787	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
488538006788	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
488538006789	histidinol dehydrogenase; Region: hisD; TIGR00069
488538006790	NAD binding site [chemical binding]; other site
488538006791	dimerization interface [polypeptide binding]; other site
488538006792	product binding site; other site
488538006793	substrate binding site [chemical binding]; other site
488538006794	zinc binding site [ion binding]; other site
488538006795	catalytic residues [active]
488538006796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538006797	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
488538006798	NAD(P) binding site [chemical binding]; other site
488538006799	active site
488538006800	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
488538006801	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
488538006802	NAD(P) binding site [chemical binding]; other site
488538006803	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
488538006804	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488538006805	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
488538006806	dimer interface [polypeptide binding]; other site
488538006807	active site
488538006808	metal binding site [ion binding]; metal-binding site
488538006809	glutathione binding site [chemical binding]; other site
488538006810	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
488538006811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488538006812	motif II; other site
488538006813	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
488538006814	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
488538006815	amidase catalytic site [active]
488538006816	Zn binding residues [ion binding]; other site
488538006817	substrate binding site [chemical binding]; other site
488538006818	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
488538006819	NlpC/P60 family; Region: NLPC_P60; cl17555
488538006820	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
488538006821	fructuronate transporter; Provisional; Region: PRK10034; cl15264
488538006822	muropeptide transporter; Validated; Region: ampG; cl17669
488538006823	muropeptide transporter; Reviewed; Region: ampG; PRK11902
488538006824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
488538006825	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
488538006826	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
488538006827	putative active site [active]
488538006828	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
488538006829	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
488538006830	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
488538006831	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538006832	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
488538006833	putative hydrophobic ligand binding site [chemical binding]; other site
488538006834	hypothetical protein; Provisional; Region: PRK07550
488538006835	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538006836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538006837	homodimer interface [polypeptide binding]; other site
488538006838	catalytic residue [active]
488538006839	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
488538006840	putative FMN binding site [chemical binding]; other site
488538006841	putative dimer interface [polypeptide binding]; other site
488538006842	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
488538006843	MarR family; Region: MarR_2; cl17246
488538006844	Helix-turn-helix domain; Region: HTH_18; pfam12833
488538006845	hypothetical protein; Provisional; Region: PRK09262
488538006846	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
488538006847	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
488538006848	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
488538006849	catalytic loop [active]
488538006850	iron binding site [ion binding]; other site
488538006851	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
488538006852	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
488538006853	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
488538006854	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
488538006855	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
488538006856	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
488538006857	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
488538006858	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488538006859	motif II; other site
488538006860	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
488538006861	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
488538006862	inhibitor site; inhibition site
488538006863	active site
488538006864	dimer interface [polypeptide binding]; other site
488538006865	catalytic residue [active]
488538006866	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538006867	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
488538006868	NAD(P) binding site [chemical binding]; other site
488538006869	catalytic residues [active]
488538006870	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
488538006871	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
488538006872	NAD(P) binding site [chemical binding]; other site
488538006873	catalytic residues [active]
488538006874	catalytic residues [active]
488538006875	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
488538006876	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488538006877	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488538006878	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
488538006879	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
488538006880	tetramer interface [polypeptide binding]; other site
488538006881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538006882	catalytic residue [active]
488538006883	putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486
488538006884	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538006885	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488538006886	hydroxyglutarate oxidase; Provisional; Region: PRK11728
488538006887	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
488538006888	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
488538006889	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
488538006890	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
488538006891	DNA-binding site [nucleotide binding]; DNA binding site
488538006892	RNA-binding motif; other site
488538006893	Predicted permeases [General function prediction only]; Region: RarD; COG2962
488538006894	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
488538006895	active site
488538006896	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
488538006897	Ligand Binding Site [chemical binding]; other site
488538006898	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
488538006899	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488538006900	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488538006901	dimerization interface [polypeptide binding]; other site
488538006902	putative DNA binding site [nucleotide binding]; other site
488538006903	putative Zn2+ binding site [ion binding]; other site
488538006904	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
488538006905	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
488538006906	putative active site [active]
488538006907	putative CoA binding site [chemical binding]; other site
488538006908	nudix motif; other site
488538006909	metal binding site [ion binding]; metal-binding site
488538006910	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
488538006911	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
488538006912	active site
488538006913	NTP binding site [chemical binding]; other site
488538006914	metal binding triad [ion binding]; metal-binding site
488538006915	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
488538006916	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
488538006917	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
488538006918	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
488538006919	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
488538006920	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
488538006921	[2Fe-2S] cluster binding site [ion binding]; other site
488538006922	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
488538006923	cytochrome b; Provisional; Region: CYTB; MTH00156
488538006924	Qi binding site; other site
488538006925	intrachain domain interface; other site
488538006926	interchain domain interface [polypeptide binding]; other site
488538006927	heme bH binding site [chemical binding]; other site
488538006928	heme bL binding site [chemical binding]; other site
488538006929	Qo binding site; other site
488538006930	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
488538006931	interchain domain interface [polypeptide binding]; other site
488538006932	intrachain domain interface; other site
488538006933	Qi binding site; other site
488538006934	Qo binding site; other site
488538006935	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
488538006936	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538006937	EamA-like transporter family; Region: EamA; pfam00892
488538006938	GTP-binding protein YchF; Reviewed; Region: PRK09601
488538006939	YchF GTPase; Region: YchF; cd01900
488538006940	G1 box; other site
488538006941	GTP/Mg2+ binding site [chemical binding]; other site
488538006942	Switch I region; other site
488538006943	G2 box; other site
488538006944	Switch II region; other site
488538006945	G3 box; other site
488538006946	G4 box; other site
488538006947	G5 box; other site
488538006948	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
488538006949	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
488538006950	putative active site [active]
488538006951	catalytic residue [active]
488538006952	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
488538006953	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
488538006954	5S rRNA interface [nucleotide binding]; other site
488538006955	CTC domain interface [polypeptide binding]; other site
488538006956	L16 interface [polypeptide binding]; other site
488538006957	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
488538006958	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
488538006959	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488538006960	active site
488538006961	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
488538006962	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
488538006963	Uncharacterized conserved protein [Function unknown]; Region: COG1565
488538006964	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
488538006965	Membrane fusogenic activity; Region: BMFP; pfam04380
488538006966	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
488538006967	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
488538006968	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
488538006969	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
488538006970	dimer interface [polypeptide binding]; other site
488538006971	putative tRNA-binding site [nucleotide binding]; other site
488538006972	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488538006973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488538006974	dimerization interface [polypeptide binding]; other site
488538006975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488538006976	dimer interface [polypeptide binding]; other site
488538006977	phosphorylation site [posttranslational modification]
488538006978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488538006979	ATP binding site [chemical binding]; other site
488538006980	Mg2+ binding site [ion binding]; other site
488538006981	G-X-G motif; other site
488538006982	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488538006983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488538006984	active site
488538006985	phosphorylation site [posttranslational modification]
488538006986	intermolecular recognition site; other site
488538006987	dimerization interface [polypeptide binding]; other site
488538006988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488538006989	DNA binding site [nucleotide binding]
488538006990	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
488538006991	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488538006992	dimerization interface [polypeptide binding]; other site
488538006993	putative Zn2+ binding site [ion binding]; other site
488538006994	putative DNA binding site [nucleotide binding]; other site
488538006995	branched-chain amino acid aminotransferase; Validated; Region: PRK07544
488538006996	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
488538006997	homodimer interface [polypeptide binding]; other site
488538006998	substrate-cofactor binding pocket; other site
488538006999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538007000	catalytic residue [active]
488538007001	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
488538007002	MoaE interaction surface [polypeptide binding]; other site
488538007003	MoeB interaction surface [polypeptide binding]; other site
488538007004	thiocarboxylated glycine; other site
488538007005	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
488538007006	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
488538007007	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
488538007008	GIY-YIG motif/motif A; other site
488538007009	active site
488538007010	catalytic site [active]
488538007011	putative DNA binding site [nucleotide binding]; other site
488538007012	metal binding site [ion binding]; metal-binding site
488538007013	UvrB/uvrC motif; Region: UVR; pfam02151
488538007014	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
488538007015	excinuclease ABC subunit B; Provisional; Region: PRK05298
488538007016	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488538007017	ATP binding site [chemical binding]; other site
488538007018	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488538007019	nucleotide binding region [chemical binding]; other site
488538007020	ATP-binding site [chemical binding]; other site
488538007021	Ultra-violet resistance protein B; Region: UvrB; pfam12344
488538007022	UvrB/uvrC motif; Region: UVR; pfam02151
488538007023	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
488538007024	aspartate aminotransferase; Provisional; Region: PRK05764
488538007025	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488538007026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538007027	homodimer interface [polypeptide binding]; other site
488538007028	catalytic residue [active]
488538007029	Cadherin prodomain like; Region: Cadherin_pro; cl07391
488538007030	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
488538007031	active site
488538007032	TMAO/DMSO reductase; Reviewed; Region: PRK05363
488538007033	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
488538007034	Moco binding site; other site
488538007035	metal coordination site [ion binding]; other site
488538007036	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
488538007037	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
488538007038	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488538007039	putative DNA binding site [nucleotide binding]; other site
488538007040	putative Zn2+ binding site [ion binding]; other site
488538007041	AsnC family; Region: AsnC_trans_reg; pfam01037
488538007042	DNA binding domain, excisionase family; Region: excise; TIGR01764
488538007043	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
488538007044	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
488538007045	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
488538007046	metal binding site 2 [ion binding]; metal-binding site
488538007047	putative DNA binding helix; other site
488538007048	metal binding site 1 [ion binding]; metal-binding site
488538007049	dimer interface [polypeptide binding]; other site
488538007050	structural Zn2+ binding site [ion binding]; other site
488538007051	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
488538007052	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
488538007053	putative PBP binding regions; other site
488538007054	ABC-ATPase subunit  interface; other site
488538007055	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
488538007056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538007057	Walker A/P-loop; other site
488538007058	ATP binding site [chemical binding]; other site
488538007059	Q-loop/lid; other site
488538007060	ABC transporter signature motif; other site
488538007061	Walker B; other site
488538007062	D-loop; other site
488538007063	H-loop/switch region; other site
488538007064	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
488538007065	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
488538007066	metal binding site [ion binding]; metal-binding site
488538007067	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
488538007068	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
488538007069	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
488538007070	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
488538007071	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488538007072	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
488538007073	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
488538007074	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488538007075	ATP-grasp domain; Region: ATP-grasp_4; cl17255
488538007076	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
488538007077	IMP binding site; other site
488538007078	dimer interface [polypeptide binding]; other site
488538007079	interdomain contacts; other site
488538007080	partial ornithine binding site; other site
488538007081	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
488538007082	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
488538007083	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
488538007084	catalytic site [active]
488538007085	subunit interface [polypeptide binding]; other site
488538007086	Yqey-like protein; Region: YqeY; pfam09424
488538007087	DNA primase, catalytic core; Region: dnaG; TIGR01391
488538007088	CHC2 zinc finger; Region: zf-CHC2; pfam01807
488538007089	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
488538007090	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
488538007091	active site
488538007092	metal binding site [ion binding]; metal-binding site
488538007093	interdomain interaction site; other site
488538007094	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
488538007095	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
488538007096	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
488538007097	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
488538007098	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
488538007099	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
488538007100	DNA binding residues [nucleotide binding]
488538007101	YCII-related domain; Region: YCII; cl00999
488538007102	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488538007103	Helix-turn-helix domain; Region: HTH_18; pfam12833
488538007104	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
488538007105	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
488538007106	DNA binding site [nucleotide binding]
488538007107	active site
488538007108	LysE type translocator; Region: LysE; cl00565
488538007109	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
488538007110	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
488538007111	active site
488538007112	D-cysteine desulfhydrase; Validated; Region: PRK03910
488538007113	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
488538007114	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538007115	catalytic residue [active]
488538007116	Predicted flavoprotein [General function prediction only]; Region: COG0431
488538007117	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
488538007118	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
488538007119	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
488538007120	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
488538007121	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
488538007122	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
488538007123	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
488538007124	catalytic triad [active]
488538007125	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
488538007126	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
488538007127	Predicted transcriptional regulator [Transcription]; Region: COG2932
488538007128	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
488538007129	Catalytic site [active]
488538007130	Uncharacterized conserved protein [Function unknown]; Region: COG5323
488538007131	Terminase-like family; Region: Terminase_6; pfam03237
488538007132	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
488538007133	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
488538007134	Phage minor tail protein; Region: Phage_min_tail; cl01940
488538007135	Phage minor tail protein L; Region: Phage_tail_L; cl01908
488538007136	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
488538007137	NlpC/P60 family; Region: NLPC_P60; cl17555
488538007138	Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945
488538007139	Putative phage tail protein; Region: Phage-tail_3; pfam13550
488538007140	Gram-negative porin; Region: Porin_4; pfam13609
488538007141	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
488538007142	catalytic residue [active]
488538007143	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
488538007144	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
488538007145	substrate binding pocket [chemical binding]; other site
488538007146	chain length determination region; other site
488538007147	substrate-Mg2+ binding site; other site
488538007148	catalytic residues [active]
488538007149	aspartate-rich region 1; other site
488538007150	active site lid residues [active]
488538007151	aspartate-rich region 2; other site
488538007152	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
488538007153	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
488538007154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538007155	S-adenosylmethionine binding site [chemical binding]; other site
488538007156	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
488538007157	tandem repeat interface [polypeptide binding]; other site
488538007158	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
488538007159	oligomer interface [polypeptide binding]; other site
488538007160	active site residues [active]
488538007161	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
488538007162	dimer interface [polypeptide binding]; other site
488538007163	motif 1; other site
488538007164	active site
488538007165	motif 2; other site
488538007166	motif 3; other site
488538007167	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
488538007168	pyruvate phosphate dikinase; Provisional; Region: PRK09279
488538007169	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
488538007170	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
488538007171	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
488538007172	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
488538007173	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
488538007174	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488538007175	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
488538007176	Walker A/P-loop; other site
488538007177	ATP binding site [chemical binding]; other site
488538007178	Q-loop/lid; other site
488538007179	ABC transporter signature motif; other site
488538007180	Walker B; other site
488538007181	D-loop; other site
488538007182	H-loop/switch region; other site
488538007183	hypothetical protein; Validated; Region: PRK09039
488538007184	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
488538007185	ligand binding site [chemical binding]; other site
488538007186	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
488538007187	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
488538007188	active site
488538007189	dimerization interface [polypeptide binding]; other site
488538007190	elongation factor P; Validated; Region: PRK00529
488538007191	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
488538007192	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
488538007193	RNA binding site [nucleotide binding]; other site
488538007194	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
488538007195	RNA binding site [nucleotide binding]; other site
488538007196	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
488538007197	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
488538007198	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
488538007199	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
488538007200	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
488538007201	TPP-binding site [chemical binding]; other site
488538007202	dimer interface [polypeptide binding]; other site
488538007203	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
488538007204	PYR/PP interface [polypeptide binding]; other site
488538007205	dimer interface [polypeptide binding]; other site
488538007206	TPP binding site [chemical binding]; other site
488538007207	Cell division protein ZapA; Region: ZapA; pfam05164
488538007208	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
488538007209	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
488538007210	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
488538007211	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
488538007212	putative active site [active]
488538007213	metal binding site [ion binding]; metal-binding site
488538007214	homodimer binding site [polypeptide binding]; other site
488538007215	hypothetical protein; Validated; Region: PRK00110
488538007216	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
488538007217	active site
488538007218	putative DNA-binding cleft [nucleotide binding]; other site
488538007219	dimer interface [polypeptide binding]; other site
488538007220	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
488538007221	RuvA N terminal domain; Region: RuvA_N; pfam01330
488538007222	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
488538007223	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
488538007224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538007225	Walker A motif; other site
488538007226	ATP binding site [chemical binding]; other site
488538007227	Walker B motif; other site
488538007228	arginine finger; other site
488538007229	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
488538007230	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
488538007231	active site
488538007232	TolQ protein; Region: tolQ; TIGR02796
488538007233	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
488538007234	TolR protein; Region: tolR; TIGR02801
488538007235	translocation protein TolB; Provisional; Region: tolB; PRK05137
488538007236	TolB amino-terminal domain; Region: TolB_N; pfam04052
488538007237	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
488538007238	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
488538007239	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
488538007240	ligand binding site [chemical binding]; other site
488538007241	Tetratricopeptide repeat; Region: TPR_16; pfam13432
488538007242	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
488538007243	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
488538007244	Ligand Binding Site [chemical binding]; other site
488538007245	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
488538007246	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538007247	Walker A motif; other site
488538007248	ATP binding site [chemical binding]; other site
488538007249	Walker B motif; other site
488538007250	arginine finger; other site
488538007251	Peptidase family M41; Region: Peptidase_M41; pfam01434
488538007252	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
488538007253	dihydropteroate synthase; Region: DHPS; TIGR01496
488538007254	substrate binding pocket [chemical binding]; other site
488538007255	dimer interface [polypeptide binding]; other site
488538007256	inhibitor binding site; inhibition site
488538007257	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
488538007258	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
488538007259	active site
488538007260	substrate binding site [chemical binding]; other site
488538007261	metal binding site [ion binding]; metal-binding site
488538007262	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
488538007263	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538007264	catalytic residue [active]
488538007265	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
488538007266	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
488538007267	ligand binding site [chemical binding]; other site
488538007268	NAD binding site [chemical binding]; other site
488538007269	dimerization interface [polypeptide binding]; other site
488538007270	catalytic site [active]
488538007271	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
488538007272	putative L-serine binding site [chemical binding]; other site
488538007273	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
488538007274	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
488538007275	GDP-binding site [chemical binding]; other site
488538007276	ACT binding site; other site
488538007277	IMP binding site; other site
488538007278	PemK-like protein; Region: PemK; pfam02452
488538007279	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
488538007280	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
488538007281	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
488538007282	DNA binding residues [nucleotide binding]
488538007283	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
488538007284	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538007285	RNA binding surface [nucleotide binding]; other site
488538007286	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
488538007287	active site
488538007288	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
488538007289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488538007290	Walker A/P-loop; other site
488538007291	ATP binding site [chemical binding]; other site
488538007292	Q-loop/lid; other site
488538007293	ABC transporter signature motif; other site
488538007294	Walker B; other site
488538007295	D-loop; other site
488538007296	H-loop/switch region; other site
488538007297	ABC transporter; Region: ABC_tran_2; pfam12848
488538007298	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488538007299	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
488538007300	VacJ like lipoprotein; Region: VacJ; cl01073
488538007301	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
488538007302	Part of AAA domain; Region: AAA_19; pfam13245
488538007303	Family description; Region: UvrD_C_2; pfam13538
488538007304	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
488538007305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538007306	S-adenosylmethionine binding site [chemical binding]; other site
488538007307	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488538007308	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488538007309	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
488538007310	active site
488538007311	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
488538007312	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
488538007313	nucleotide binding pocket [chemical binding]; other site
488538007314	K-X-D-G motif; other site
488538007315	catalytic site [active]
488538007316	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
488538007317	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
488538007318	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
488538007319	Dimer interface [polypeptide binding]; other site
488538007320	BRCT sequence motif; other site
488538007321	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
488538007322	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
488538007323	Walker A/P-loop; other site
488538007324	ATP binding site [chemical binding]; other site
488538007325	Q-loop/lid; other site
488538007326	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
488538007327	Q-loop/lid; other site
488538007328	ABC transporter signature motif; other site
488538007329	Walker B; other site
488538007330	D-loop; other site
488538007331	H-loop/switch region; other site
488538007332	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
488538007333	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
488538007334	binding surface
488538007335	TPR motif; other site
488538007336	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
488538007337	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
488538007338	cell division protein FtsZ; Validated; Region: PRK09330
488538007339	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
488538007340	nucleotide binding site [chemical binding]; other site
488538007341	SulA interaction site; other site
488538007342	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
488538007343	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
488538007344	Cell division protein FtsA; Region: FtsA; pfam14450
488538007345	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
488538007346	Cell division protein FtsA; Region: FtsA; pfam14450
488538007347	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
488538007348	Cell division protein FtsQ; Region: FtsQ; pfam03799
488538007349	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
488538007350	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
488538007351	ATP-grasp domain; Region: ATP-grasp_4; cl17255
488538007352	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
488538007353	FAD binding domain; Region: FAD_binding_4; pfam01565
488538007354	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
488538007355	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
488538007356	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
488538007357	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488538007358	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488538007359	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
488538007360	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
488538007361	active site
488538007362	homodimer interface [polypeptide binding]; other site
488538007363	cell division protein FtsW; Region: ftsW; TIGR02614
488538007364	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
488538007365	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488538007366	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488538007367	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
488538007368	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
488538007369	Mg++ binding site [ion binding]; other site
488538007370	putative catalytic motif [active]
488538007371	putative substrate binding site [chemical binding]; other site
488538007372	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
488538007373	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
488538007374	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488538007375	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
488538007376	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
488538007377	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488538007378	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488538007379	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
488538007380	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
488538007381	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
488538007382	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
488538007383	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
488538007384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538007385	S-adenosylmethionine binding site [chemical binding]; other site
488538007386	MraZ protein; Region: MraZ; pfam02381
488538007387	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
488538007388	MraZ protein; Region: MraZ; pfam02381
488538007389	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
488538007390	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
488538007391	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488538007392	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488538007393	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
488538007394	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
488538007395	putative metal binding site [ion binding]; other site
488538007396	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
488538007397	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
488538007398	CPxP  motif; other site
488538007399	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
488538007400	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
488538007401	putative acyl-acceptor binding pocket; other site
488538007402	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
488538007403	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
488538007404	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
488538007405	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
488538007406	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
488538007407	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
488538007408	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
488538007409	LytTr DNA-binding domain; Region: LytTR; pfam04397
488538007410	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
488538007411	active site residue [active]
488538007412	Tetratricopeptide repeat; Region: TPR_16; pfam13432
488538007413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488538007414	binding surface
488538007415	Tetratricopeptide repeat; Region: TPR_16; pfam13432
488538007416	TPR motif; other site
488538007417	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
488538007418	catalytic residues [active]
488538007419	dimer interface [polypeptide binding]; other site
488538007420	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538007421	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
488538007422	C-terminal domain interface [polypeptide binding]; other site
488538007423	GSH binding site (G-site) [chemical binding]; other site
488538007424	dimer interface [polypeptide binding]; other site
488538007425	SET domain; Region: SET; pfam00856
488538007426	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
488538007427	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538007428	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
488538007429	C-terminal domain interface [polypeptide binding]; other site
488538007430	GSH binding site (G-site) [chemical binding]; other site
488538007431	dimer interface [polypeptide binding]; other site
488538007432	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
488538007433	dimer interface [polypeptide binding]; other site
488538007434	substrate binding pocket (H-site) [chemical binding]; other site
488538007435	N-terminal domain interface [polypeptide binding]; other site
488538007436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488538007437	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
488538007438	NAD(P) binding site [chemical binding]; other site
488538007439	active site
488538007440	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
488538007441	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488538007442	motif II; other site
488538007443	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538007444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538007445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538007446	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
488538007447	dimerization interface [polypeptide binding]; other site
488538007448	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
488538007449	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
488538007450	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
488538007451	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
488538007452	elongation factor Tu; Reviewed; Region: PRK00049
488538007453	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
488538007454	G1 box; other site
488538007455	GEF interaction site [polypeptide binding]; other site
488538007456	GTP/Mg2+ binding site [chemical binding]; other site
488538007457	Switch I region; other site
488538007458	G2 box; other site
488538007459	G3 box; other site
488538007460	Switch II region; other site
488538007461	G4 box; other site
488538007462	G5 box; other site
488538007463	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
488538007464	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
488538007465	Antibiotic Binding Site [chemical binding]; other site
488538007466	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
488538007467	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
488538007468	tetramer interface [polypeptide binding]; other site
488538007469	active site
488538007470	Mg2+/Mn2+ binding site [ion binding]; other site
488538007471	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538007472	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
488538007473	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
488538007474	N-terminal domain interface [polypeptide binding]; other site
488538007475	dimer interface [polypeptide binding]; other site
488538007476	substrate binding pocket (H-site) [chemical binding]; other site
488538007477	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
488538007478	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
488538007479	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
488538007480	putative homodimer interface [polypeptide binding]; other site
488538007481	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
488538007482	heterodimer interface [polypeptide binding]; other site
488538007483	homodimer interface [polypeptide binding]; other site
488538007484	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
488538007485	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
488538007486	23S rRNA interface [nucleotide binding]; other site
488538007487	L7/L12 interface [polypeptide binding]; other site
488538007488	putative thiostrepton binding site; other site
488538007489	L25 interface [polypeptide binding]; other site
488538007490	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
488538007491	mRNA/rRNA interface [nucleotide binding]; other site
488538007492	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
488538007493	23S rRNA interface [nucleotide binding]; other site
488538007494	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
488538007495	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
488538007496	L11 interface [polypeptide binding]; other site
488538007497	putative EF-Tu interaction site [polypeptide binding]; other site
488538007498	putative EF-G interaction site [polypeptide binding]; other site
488538007499	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
488538007500	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
488538007501	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
488538007502	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
488538007503	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
488538007504	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
488538007505	RPB1 interaction site [polypeptide binding]; other site
488538007506	RPB11 interaction site [polypeptide binding]; other site
488538007507	RPB10 interaction site [polypeptide binding]; other site
488538007508	RPB3 interaction site [polypeptide binding]; other site
488538007509	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
488538007510	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
488538007511	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
488538007512	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
488538007513	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
488538007514	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
488538007515	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
488538007516	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
488538007517	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
488538007518	DNA binding site [nucleotide binding]
488538007519	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
488538007520	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
488538007521	S17 interaction site [polypeptide binding]; other site
488538007522	S8 interaction site; other site
488538007523	16S rRNA interaction site [nucleotide binding]; other site
488538007524	streptomycin interaction site [chemical binding]; other site
488538007525	23S rRNA interaction site [nucleotide binding]; other site
488538007526	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
488538007527	30S ribosomal protein S7; Validated; Region: PRK05302
488538007528	elongation factor G; Reviewed; Region: PRK00007
488538007529	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
488538007530	G1 box; other site
488538007531	putative GEF interaction site [polypeptide binding]; other site
488538007532	GTP/Mg2+ binding site [chemical binding]; other site
488538007533	Switch I region; other site
488538007534	G2 box; other site
488538007535	G3 box; other site
488538007536	Switch II region; other site
488538007537	G4 box; other site
488538007538	G5 box; other site
488538007539	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
488538007540	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
488538007541	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
488538007542	elongation factor Tu; Reviewed; Region: PRK00049
488538007543	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
488538007544	G1 box; other site
488538007545	GEF interaction site [polypeptide binding]; other site
488538007546	GTP/Mg2+ binding site [chemical binding]; other site
488538007547	Switch I region; other site
488538007548	G2 box; other site
488538007549	G3 box; other site
488538007550	Switch II region; other site
488538007551	G4 box; other site
488538007552	G5 box; other site
488538007553	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
488538007554	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
488538007555	Antibiotic Binding Site [chemical binding]; other site
488538007556	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
488538007557	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
488538007558	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
488538007559	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
488538007560	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
488538007561	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
488538007562	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
488538007563	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
488538007564	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
488538007565	putative translocon binding site; other site
488538007566	protein-rRNA interface [nucleotide binding]; other site
488538007567	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
488538007568	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
488538007569	G-X-X-G motif; other site
488538007570	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
488538007571	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
488538007572	23S rRNA interface [nucleotide binding]; other site
488538007573	5S rRNA interface [nucleotide binding]; other site
488538007574	putative antibiotic binding site [chemical binding]; other site
488538007575	L25 interface [polypeptide binding]; other site
488538007576	L27 interface [polypeptide binding]; other site
488538007577	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
488538007578	putative translocon interaction site; other site
488538007579	23S rRNA interface [nucleotide binding]; other site
488538007580	signal recognition particle (SRP54) interaction site; other site
488538007581	L23 interface [polypeptide binding]; other site
488538007582	trigger factor interaction site; other site
488538007583	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
488538007584	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
488538007585	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
488538007586	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
488538007587	RNA binding site [nucleotide binding]; other site
488538007588	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
488538007589	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
488538007590	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
488538007591	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
488538007592	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
488538007593	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
488538007594	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
488538007595	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
488538007596	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
488538007597	5S rRNA interface [nucleotide binding]; other site
488538007598	23S rRNA interface [nucleotide binding]; other site
488538007599	L5 interface [polypeptide binding]; other site
488538007600	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
488538007601	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
488538007602	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
488538007603	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
488538007604	23S rRNA binding site [nucleotide binding]; other site
488538007605	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
488538007606	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
488538007607	SecY translocase; Region: SecY; pfam00344
488538007608	adenylate kinase; Reviewed; Region: adk; PRK00279
488538007609	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
488538007610	AMP-binding site [chemical binding]; other site
488538007611	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
488538007612	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
488538007613	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
488538007614	30S ribosomal protein S11; Validated; Region: PRK05309
488538007615	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
488538007616	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
488538007617	alphaNTD homodimer interface [polypeptide binding]; other site
488538007618	alphaNTD - beta interaction site [polypeptide binding]; other site
488538007619	alphaNTD - beta' interaction site [polypeptide binding]; other site
488538007620	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
488538007621	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
488538007622	recombination factor protein RarA; Reviewed; Region: PRK13342
488538007623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488538007624	Walker A motif; other site
488538007625	ATP binding site [chemical binding]; other site
488538007626	Walker B motif; other site
488538007627	arginine finger; other site
488538007628	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
488538007629	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
488538007630	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
488538007631	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488538007632	RNA binding surface [nucleotide binding]; other site
488538007633	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
488538007634	active site
488538007635	ATP12 chaperone protein; Region: ATP12; cl02228
488538007636	lipoate-protein ligase B; Provisional; Region: PRK14341
488538007637	Methyltransferase domain; Region: Methyltransf_23; pfam13489
488538007638	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
488538007639	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
488538007640	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
488538007641	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
488538007642	tetramer interface [polypeptide binding]; other site
488538007643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488538007644	catalytic residue [active]
488538007645	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
488538007646	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
488538007647	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
488538007648	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
488538007649	catalytic core [active]
488538007650	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
488538007651	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
488538007652	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
488538007653	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
488538007654	putative active site [active]
488538007655	putative metal binding site [ion binding]; other site
488538007656	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
488538007657	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488538007658	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
488538007659	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
488538007660	GAF domain; Region: GAF; pfam01590
488538007661	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
488538007662	GTP cyclohydrolase I; Provisional; Region: PLN03044
488538007663	active site
488538007664	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
488538007665	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
488538007666	folate binding site [chemical binding]; other site
488538007667	NADP+ binding site [chemical binding]; other site
488538007668	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
488538007669	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
488538007670	active site
488538007671	catalytic tetrad [active]
488538007672	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
488538007673	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
488538007674	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
488538007675	N-terminal domain interface [polypeptide binding]; other site
488538007676	dimer interface [polypeptide binding]; other site
488538007677	substrate binding pocket (H-site) [chemical binding]; other site
488538007678	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
488538007679	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
488538007680	FMN binding site [chemical binding]; other site
488538007681	active site
488538007682	substrate binding site [chemical binding]; other site
488538007683	catalytic residue [active]
488538007684	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
488538007685	Predicted permeases [General function prediction only]; Region: COG0679
488538007686	Cytochrome C' Region: Cytochrom_C_2; pfam01322
488538007687	NIPSNAP; Region: NIPSNAP; pfam07978
488538007688	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
488538007689	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
488538007690	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
488538007691	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
488538007692	active site
488538007693	dimer interface [polypeptide binding]; other site
488538007694	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
488538007695	dimer interface [polypeptide binding]; other site
488538007696	active site
488538007697	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
488538007698	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
488538007699	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488538007700	catalytic residue [active]
488538007701	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
488538007702	GIY-YIG motif/motif A; other site
488538007703	putative active site [active]
488538007704	putative metal binding site [ion binding]; other site
488538007705	HI0933-like protein; Region: HI0933_like; pfam03486
488538007706	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
488538007707	active site clefts [active]
488538007708	zinc binding site [ion binding]; other site
488538007709	dimer interface [polypeptide binding]; other site
488538007710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488538007711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488538007712	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
488538007713	dimerization interface [polypeptide binding]; other site
488538007714	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
488538007715	Nitrogen regulatory protein P-II; Region: P-II; smart00938
488538007716	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
488538007717	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
488538007718	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
488538007719	Walker A/P-loop; other site
488538007720	ATP binding site [chemical binding]; other site
488538007721	Q-loop/lid; other site
488538007722	ABC transporter signature motif; other site
488538007723	Walker B; other site
488538007724	D-loop; other site
488538007725	H-loop/switch region; other site
488538007726	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
488538007727	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538007728	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
488538007729	TM-ABC transporter signature motif; other site
488538007730	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488538007731	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
488538007732	TM-ABC transporter signature motif; other site
488538007733	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
488538007734	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
488538007735	putative ligand binding site [chemical binding]; other site
488538007736	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
488538007737	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
488538007738	dimerization interface [polypeptide binding]; other site
488538007739	ligand binding site [chemical binding]; other site
488538007740	NADP binding site [chemical binding]; other site
488538007741	catalytic site [active]
488538007742	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
488538007743	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
488538007744	MOFRL family; Region: MOFRL; pfam05161
488538007745	isocitrate lyase; Provisional; Region: PRK15063
488538007746	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
488538007747	tetramer interface [polypeptide binding]; other site
488538007748	active site
488538007749	Mg2+/Mn2+ binding site [ion binding]; other site
488538007750	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488538007751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488538007752	non-specific DNA binding site [nucleotide binding]; other site
488538007753	salt bridge; other site
488538007754	sequence-specific DNA binding site [nucleotide binding]; other site
488538007755	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
488538007756	Domain of unknown function (DUF955); Region: DUF955; pfam06114
488538007757	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
488538007758	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
488538007759	MgtE intracellular N domain; Region: MgtE_N; smart00924
488538007760	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
488538007761	Divalent cation transporter; Region: MgtE; pfam01769
488538007762	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
488538007763	Staphylococcal nuclease homologues; Region: SNc; smart00318
488538007764	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
488538007765	Catalytic site; other site
488538007766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538007767	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538007768	putative substrate translocation pore; other site
488538007769	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
488538007770	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
488538007771	metal binding triad; other site
488538007772	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
488538007773	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
488538007774	metal binding triad; other site
488538007775	multidrug efflux protein; Reviewed; Region: PRK01766
488538007776	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
488538007777	cation binding site [ion binding]; other site
488538007778	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
488538007779	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
488538007780	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
488538007781	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488538007782	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
488538007783	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
488538007784	active site
488538007785	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
488538007786	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
488538007787	GMP synthase; Reviewed; Region: guaA; PRK00074
488538007788	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
488538007789	AMP/PPi binding site [chemical binding]; other site
488538007790	candidate oxyanion hole; other site
488538007791	catalytic triad [active]
488538007792	potential glutamine specificity residues [chemical binding]; other site
488538007793	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
488538007794	ATP Binding subdomain [chemical binding]; other site
488538007795	Ligand Binding sites [chemical binding]; other site
488538007796	Dimerization subdomain; other site
488538007797	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
488538007798	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488538007799	active site
488538007800	catalytic residues [active]
488538007801	DNA binding site [nucleotide binding]
488538007802	Int/Topo IB signature motif; other site
488538007803	Cupin domain; Region: Cupin_2; cl17218
488538007804	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
488538007805	potential frameshift: common BLAST hit: gi|209549735|ref|YP_002281652.1| Lysine exporter protein (LYSE/YGGA)
488538007806	LysE type translocator; Region: LysE; cl00565
488538007807	LysE type translocator; Region: LysE; cl00565
488538007808	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
488538007809	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
488538007810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
488538007811	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
488538007812	Trp docking motif [polypeptide binding]; other site
488538007813	active site
488538007814	PQQ-like domain; Region: PQQ_2; pfam13360
488538007815	PQQ-like domain; Region: PQQ_2; pfam13360
488538007816	GTP-binding protein Der; Reviewed; Region: PRK00093
488538007817	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
488538007818	G1 box; other site
488538007819	GTP/Mg2+ binding site [chemical binding]; other site
488538007820	Switch I region; other site
488538007821	G2 box; other site
488538007822	Switch II region; other site
488538007823	G3 box; other site
488538007824	G4 box; other site
488538007825	G5 box; other site
488538007826	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
488538007827	G1 box; other site
488538007828	GTP/Mg2+ binding site [chemical binding]; other site
488538007829	Switch I region; other site
488538007830	G2 box; other site
488538007831	G3 box; other site
488538007832	Switch II region; other site
488538007833	G4 box; other site
488538007834	G5 box; other site
488538007835	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
488538007836	EamA-like transporter family; Region: EamA; pfam00892
488538007837	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
488538007838	phenol 2-monooxygenase; Provisional; Region: PRK08294
488538007839	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488538007840	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
488538007841	dimer interface [polypeptide binding]; other site
488538007842	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
488538007843	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
488538007844	putative FMN binding site [chemical binding]; other site
488538007845	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
488538007846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488538007847	FeS/SAM binding site; other site
488538007848	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
488538007849	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
488538007850	Walker A motif; other site
488538007851	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
488538007852	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
488538007853	dimer interface [polypeptide binding]; other site
488538007854	putative functional site; other site
488538007855	putative MPT binding site; other site
488538007856	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
488538007857	MoaE homodimer interface [polypeptide binding]; other site
488538007858	MoaD interaction [polypeptide binding]; other site
488538007859	active site residues [active]
488538007860	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
488538007861	Methyltransferase domain; Region: Methyltransf_23; pfam13489
488538007862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488538007863	S-adenosylmethionine binding site [chemical binding]; other site
488538007864	short chain dehydrogenase; Provisional; Region: PRK06123
488538007865	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
488538007866	NADP binding site [chemical binding]; other site
488538007867	homodimer interface [polypeptide binding]; other site
488538007868	active site
488538007869	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
488538007870	Nitronate monooxygenase; Region: NMO; pfam03060
488538007871	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
488538007872	FMN binding site [chemical binding]; other site
488538007873	substrate binding site [chemical binding]; other site
488538007874	putative catalytic residue [active]
488538007875	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
488538007876	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
488538007877	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
488538007878	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
488538007879	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
488538007880	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488538007881	Walker A motif; other site
488538007882	ATP binding site [chemical binding]; other site
488538007883	Walker B motif; other site
488538007884	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
488538007885	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
488538007886	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
488538007887	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
488538007888	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
488538007889	Sel1 repeat; Region: Sel1; cl02723
488538007890	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
488538007891	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488538007892	Walker A motif; other site
488538007893	ATP binding site [chemical binding]; other site
488538007894	Walker B motif; other site
488538007895	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
488538007896	anti sigma factor interaction site; other site
488538007897	regulatory phosphorylation site [posttranslational modification]; other site
488538007898	GAF domain; Region: GAF; cl17456
488538007899	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
488538007900	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
488538007901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
488538007902	Protein of unknown function (DUF330); Region: DUF330; cl01135
488538007903	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
488538007904	mce related protein; Region: MCE; pfam02470
488538007905	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
488538007906	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
488538007907	Walker A/P-loop; other site
488538007908	ATP binding site [chemical binding]; other site
488538007909	Q-loop/lid; other site
488538007910	ABC transporter signature motif; other site
488538007911	Walker B; other site
488538007912	D-loop; other site
488538007913	H-loop/switch region; other site
488538007914	Permease; Region: Permease; pfam02405
488538007915	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
488538007916	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
488538007917	P-loop; other site
488538007918	Magnesium ion binding site [ion binding]; other site
488538007919	Major Facilitator Superfamily; Region: MFS_1; pfam07690
488538007920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488538007921	putative substrate translocation pore; other site
488538007922	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
488538007923	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
488538007924	[2Fe-2S] cluster binding site [ion binding]; other site
488538007925	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
488538007926	alpha subunit interface [polypeptide binding]; other site
488538007927	active site
488538007928	substrate binding site [chemical binding]; other site
488538007929	Fe binding site [ion binding]; other site
488538007930	hypothetical protein; Validated; Region: PRK00029
488538007931	Uncharacterized conserved protein [Function unknown]; Region: COG0397
488538007932	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
488538007933	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488538007934	putative DNA binding site [nucleotide binding]; other site
488538007935	putative Zn2+ binding site [ion binding]; other site
488538007936	AsnC family; Region: AsnC_trans_reg; pfam01037
488538007937	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
488538007938	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
488538007939	hexamer interface [polypeptide binding]; other site
488538007940	ligand binding site [chemical binding]; other site
488538007941	putative active site [active]
488538007942	NAD(P) binding site [chemical binding]; other site
488538007943	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
488538007944	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
488538007945	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
488538007946	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442