-- dump date 20140619_025003 -- class Genbank::misc_feature -- table misc_feature_note -- id note 515618000001 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 515618000002 oligomerization interface [polypeptide binding]; other site 515618000003 active site 515618000004 metal binding site [ion binding]; metal-binding site 515618000005 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000006 pantoate--beta-alanine ligase; Region: panC; TIGR00018 515618000007 active site 515618000008 nucleotide binding site [chemical binding]; other site 515618000009 HIGH motif; other site 515618000010 KMSKS motif; other site 515618000011 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 515618000012 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 515618000013 Replication initiator protein A; Region: RPA; pfam10134 515618000014 Replication initiator protein A; Region: RPA; pfam10134 515618000015 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 515618000016 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 515618000017 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 515618000018 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 515618000019 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 515618000020 rod shape-determining protein MreC; Provisional; Region: PRK13922 515618000021 Salmonella outer protein D; Region: SopD; cl14701 515618000022 rod shape-determining protein MreC; Region: MreC; pfam04085 515618000023 rod shape-determining protein MreB; Provisional; Region: PRK13927 515618000024 MreB and similar proteins; Region: MreB_like; cd10225 515618000025 putative protofilament interaction site [polypeptide binding]; other site 515618000026 nucleotide binding site [chemical binding]; other site 515618000027 RodZ interaction site [polypeptide binding]; other site 515618000028 Mg binding site [ion binding]; other site 515618000029 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 515618000030 Dehydroquinase class II; Region: DHquinase_II; pfam01220 515618000031 trimer interface [polypeptide binding]; other site 515618000032 active site 515618000033 dimer interface [polypeptide binding]; other site 515618000034 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 515618000035 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 515618000036 carboxyltransferase (CT) interaction site; other site 515618000037 biotinylation site [posttranslational modification]; other site 515618000038 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 515618000039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515618000040 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515618000041 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 515618000042 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 515618000043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515618000044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515618000045 DNA binding residues [nucleotide binding] 515618000046 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 515618000047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618000048 S-adenosylmethionine binding site [chemical binding]; other site 515618000049 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 515618000050 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 515618000051 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515618000052 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 515618000053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515618000054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515618000055 DNA binding residues [nucleotide binding] 515618000056 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 515618000057 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515618000058 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515618000059 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 515618000060 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 515618000061 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 515618000062 carboxyltransferase (CT) interaction site; other site 515618000063 biotinylation site [posttranslational modification]; other site 515618000064 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 515618000065 Dehydroquinase class II; Region: DHquinase_II; pfam01220 515618000066 trimer interface [polypeptide binding]; other site 515618000067 active site 515618000068 dimer interface [polypeptide binding]; other site 515618000069 rod shape-determining protein MreB; Provisional; Region: PRK13927 515618000070 MreB and similar proteins; Region: MreB_like; cd10225 515618000071 nucleotide binding site [chemical binding]; other site 515618000072 Mg binding site [ion binding]; other site 515618000073 putative protofilament interaction site [polypeptide binding]; other site 515618000074 RodZ interaction site [polypeptide binding]; other site 515618000075 rod shape-determining protein MreC; Provisional; Region: PRK13922 515618000076 Salmonella outer protein D; Region: SopD; cl14701 515618000077 rod shape-determining protein MreC; Region: MreC; pfam04085 515618000078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 515618000079 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 515618000080 BolA-like protein; Region: BolA; cl00386 515618000081 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 515618000082 active site 515618000083 hinge; other site 515618000084 serine endoprotease; Provisional; Region: PRK10139 515618000085 Trypsin; Region: Trypsin; pfam00089 515618000086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 515618000087 protein binding site [polypeptide binding]; other site 515618000088 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 515618000089 protein binding site [polypeptide binding]; other site 515618000090 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 515618000091 23S rRNA interface [nucleotide binding]; other site 515618000092 L3 interface [polypeptide binding]; other site 515618000093 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 515618000094 Predicted methyltransferases [General function prediction only]; Region: COG0313 515618000095 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 515618000096 putative SAM binding site [chemical binding]; other site 515618000097 putative homodimer interface [polypeptide binding]; other site 515618000098 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 515618000099 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 515618000100 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 515618000101 Flavoprotein; Region: Flavoprotein; pfam02441 515618000102 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 515618000103 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 515618000104 trimer interface [polypeptide binding]; other site 515618000105 active site 515618000106 hypothetical protein; Provisional; Region: PRK11820 515618000107 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 515618000108 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 515618000109 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 515618000110 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 515618000111 active site 515618000112 ADP/pyrophosphate binding site [chemical binding]; other site 515618000113 dimerization interface [polypeptide binding]; other site 515618000114 allosteric effector site; other site 515618000115 fructose-1,6-bisphosphate binding site; other site 515618000116 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 515618000117 fumarate hydratase; Reviewed; Region: fumC; PRK00485 515618000118 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 515618000119 tetramer interface [polypeptide binding]; other site 515618000120 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 515618000121 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 515618000122 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515618000123 minor groove reading motif; other site 515618000124 helix-hairpin-helix signature motif; other site 515618000125 substrate binding pocket [chemical binding]; other site 515618000126 active site 515618000127 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 515618000128 homotrimer interaction site [polypeptide binding]; other site 515618000129 CDP-binding sites; other site 515618000130 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 515618000131 substrate binding site; other site 515618000132 dimer interface; other site 515618000133 Septum formation initiator; Region: DivIC; cl17659 515618000134 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515618000135 active site 515618000136 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 515618000137 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 515618000138 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 515618000139 signal recognition particle protein; Provisional; Region: PRK10867 515618000140 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 515618000141 P loop; other site 515618000142 GTP binding site [chemical binding]; other site 515618000143 Signal peptide binding domain; Region: SRP_SPB; pfam02978 515618000144 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 515618000145 carbon storage regulator; Provisional; Region: PRK01712 515618000146 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 515618000147 motif 1; other site 515618000148 active site 515618000149 motif 2; other site 515618000150 motif 3; other site 515618000151 recombinase A; Provisional; Region: recA; PRK09354 515618000152 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 515618000153 hexamer interface [polypeptide binding]; other site 515618000154 Walker A motif; other site 515618000155 ATP binding site [chemical binding]; other site 515618000156 Walker B motif; other site 515618000157 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 515618000158 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 515618000159 active site 515618000160 glutathione synthetase; Provisional; Region: PRK05246 515618000161 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 515618000162 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 515618000163 hypothetical protein; Validated; Region: PRK00228 515618000164 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 515618000165 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 515618000166 glutamine binding [chemical binding]; other site 515618000167 catalytic triad [active] 515618000168 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 515618000169 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 515618000170 catalytic loop [active] 515618000171 iron binding site [ion binding]; other site 515618000172 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 515618000173 dimer interface [polypeptide binding]; other site 515618000174 putative radical transfer pathway; other site 515618000175 diiron center [ion binding]; other site 515618000176 tyrosyl radical; other site 515618000177 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 515618000178 ATP cone domain; Region: ATP-cone; pfam03477 515618000179 Class I ribonucleotide reductase; Region: RNR_I; cd01679 515618000180 active site 515618000181 dimer interface [polypeptide binding]; other site 515618000182 catalytic residues [active] 515618000183 effector binding site; other site 515618000184 R2 peptide binding site; other site 515618000185 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 515618000186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618000187 S-adenosylmethionine binding site [chemical binding]; other site 515618000188 DNA gyrase subunit A; Validated; Region: PRK05560 515618000189 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 515618000190 CAP-like domain; other site 515618000191 active site 515618000192 primary dimer interface [polypeptide binding]; other site 515618000193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515618000194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515618000195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515618000196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515618000197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515618000198 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 515618000199 5S rRNA interface [nucleotide binding]; other site 515618000200 CTC domain interface [polypeptide binding]; other site 515618000201 L16 interface [polypeptide binding]; other site 515618000202 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 515618000203 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 515618000204 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 515618000205 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515618000206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515618000207 FeS/SAM binding site; other site 515618000208 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 515618000209 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 515618000210 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 515618000211 Transporter associated domain; Region: CorC_HlyC; smart01091 515618000212 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 515618000213 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 515618000214 HIGH motif; other site 515618000215 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515618000216 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000217 active site 515618000218 KMSKS motif; other site 515618000219 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 515618000220 tRNA binding surface [nucleotide binding]; other site 515618000221 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 515618000222 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 515618000223 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 515618000224 active site 515618000225 (T/H)XGH motif; other site 515618000226 penicillin-binding protein 2; Provisional; Region: PRK10795 515618000227 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 515618000228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515618000229 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 515618000230 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 515618000231 lipoyl synthase; Provisional; Region: PRK05481 515618000232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515618000233 FeS/SAM binding site; other site 515618000234 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 515618000235 DNA-binding site [nucleotide binding]; DNA binding site 515618000236 RNA-binding motif; other site 515618000237 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 515618000238 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 515618000239 active site 515618000240 dimer interface [polypeptide binding]; other site 515618000241 prolyl-tRNA synthetase; Provisional; Region: PRK12325 515618000242 motif 1; other site 515618000243 motif 2; other site 515618000244 motif 3; other site 515618000245 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 515618000246 anticodon binding site; other site 515618000247 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 515618000248 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 515618000249 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 515618000250 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 515618000251 23S rRNA binding site [nucleotide binding]; other site 515618000252 L21 binding site [polypeptide binding]; other site 515618000253 L13 binding site [polypeptide binding]; other site 515618000254 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 515618000255 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 515618000256 dimer interface [polypeptide binding]; other site 515618000257 motif 1; other site 515618000258 active site 515618000259 motif 2; other site 515618000260 motif 3; other site 515618000261 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 515618000262 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 515618000263 putative tRNA-binding site [nucleotide binding]; other site 515618000264 B3/4 domain; Region: B3_4; pfam03483 515618000265 tRNA synthetase B5 domain; Region: B5; smart00874 515618000266 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 515618000267 dimer interface [polypeptide binding]; other site 515618000268 motif 1; other site 515618000269 motif 3; other site 515618000270 motif 2; other site 515618000271 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 515618000272 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 515618000273 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 515618000274 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 515618000275 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 515618000276 active pocket/dimerization site; other site 515618000277 active site 515618000278 phosphorylation site [posttranslational modification] 515618000279 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 515618000280 active site 515618000281 phosphorylation site [posttranslational modification] 515618000282 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 515618000283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 515618000284 chorismate binding enzyme; Region: Chorismate_bind; cl10555 515618000285 DNA-specific endonuclease I; Provisional; Region: PRK15137 515618000286 Endonuclease I; Region: Endonuclease_1; cl01003 515618000287 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 515618000288 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 515618000289 glutaminase active site [active] 515618000290 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 515618000291 dimer interface [polypeptide binding]; other site 515618000292 active site 515618000293 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 515618000294 dimer interface [polypeptide binding]; other site 515618000295 active site 515618000296 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 515618000297 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 515618000298 Substrate binding site; other site 515618000299 Mg++ binding site; other site 515618000300 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 515618000301 active site 515618000302 substrate binding site [chemical binding]; other site 515618000303 CoA binding site [chemical binding]; other site 515618000304 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 515618000305 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 515618000306 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 515618000307 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 515618000308 GMP synthase; Reviewed; Region: guaA; PRK00074 515618000309 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 515618000310 AMP/PPi binding site [chemical binding]; other site 515618000311 candidate oxyanion hole; other site 515618000312 catalytic triad [active] 515618000313 potential glutamine specificity residues [chemical binding]; other site 515618000314 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 515618000315 ATP Binding subdomain [chemical binding]; other site 515618000316 Ligand Binding sites [chemical binding]; other site 515618000317 Dimerization subdomain; other site 515618000318 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 515618000319 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 515618000320 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 515618000321 active site 515618000322 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 515618000323 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 515618000324 dimer interface [polypeptide binding]; other site 515618000325 TPP-binding site [chemical binding]; other site 515618000326 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 515618000327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 515618000328 E3 interaction surface; other site 515618000329 lipoyl attachment site [posttranslational modification]; other site 515618000330 e3 binding domain; Region: E3_binding; pfam02817 515618000331 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 515618000332 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 515618000333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515618000334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515618000335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 515618000336 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 515618000337 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515618000338 active site 515618000339 dimer interface [polypeptide binding]; other site 515618000340 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 515618000341 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 515618000342 peptide chain release factor 2; Validated; Region: prfB; PRK00578 515618000343 This domain is found in peptide chain release factors; Region: PCRF; smart00937 515618000344 RF-1 domain; Region: RF-1; pfam00472 515618000345 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 515618000346 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 515618000347 dimer interface [polypeptide binding]; other site 515618000348 putative anticodon binding site; other site 515618000349 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 515618000350 motif 1; other site 515618000351 active site 515618000352 motif 2; other site 515618000353 motif 3; other site 515618000354 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 515618000355 putative catalytic site [active] 515618000356 putative phosphate binding site [ion binding]; other site 515618000357 active site 515618000358 metal binding site A [ion binding]; metal-binding site 515618000359 DNA binding site [nucleotide binding] 515618000360 putative AP binding site [nucleotide binding]; other site 515618000361 putative metal binding site B [ion binding]; other site 515618000362 protease 4; Provisional; Region: PRK10949 515618000363 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 515618000364 tandem repeat interface [polypeptide binding]; other site 515618000365 oligomer interface [polypeptide binding]; other site 515618000366 active site residues [active] 515618000367 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 515618000368 tandem repeat interface [polypeptide binding]; other site 515618000369 oligomer interface [polypeptide binding]; other site 515618000370 active site residues [active] 515618000371 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 515618000372 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 515618000373 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 515618000374 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 515618000375 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 515618000376 NAD binding site [chemical binding]; other site 515618000377 homotetramer interface [polypeptide binding]; other site 515618000378 homodimer interface [polypeptide binding]; other site 515618000379 substrate binding site [chemical binding]; other site 515618000380 active site 515618000381 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 515618000382 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 515618000383 active site 515618000384 HIGH motif; other site 515618000385 dimer interface [polypeptide binding]; other site 515618000386 KMSKS motif; other site 515618000387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515618000388 RNA binding surface [nucleotide binding]; other site 515618000389 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 515618000390 pyruvate kinase; Provisional; Region: PRK09206 515618000391 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 515618000392 domain interfaces; other site 515618000393 active site 515618000394 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 515618000395 L,D-transpeptidase; Provisional; Region: PRK10190 515618000396 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 515618000397 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 515618000398 Fe-S metabolism associated domain; Region: SufE; cl00951 515618000399 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 515618000400 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 515618000401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515618000402 catalytic residue [active] 515618000403 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 515618000404 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 515618000405 FeS assembly ATPase SufC; Region: sufC; TIGR01978 515618000406 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 515618000407 Walker A/P-loop; other site 515618000408 ATP binding site [chemical binding]; other site 515618000409 Q-loop/lid; other site 515618000410 ABC transporter signature motif; other site 515618000411 Walker B; other site 515618000412 D-loop; other site 515618000413 H-loop/switch region; other site 515618000414 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 515618000415 putative ABC transporter; Region: ycf24; CHL00085 515618000416 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 515618000417 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 515618000418 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 515618000419 putative protease; Provisional; Region: PRK15452 515618000420 Peptidase family U32; Region: Peptidase_U32; pfam01136 515618000421 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 515618000422 Divalent cation transporter; Region: MgtE; cl00786 515618000423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515618000424 active site 515618000425 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 515618000426 dihydrodipicolinate synthase; Region: dapA; TIGR00674 515618000427 dimer interface [polypeptide binding]; other site 515618000428 active site 515618000429 catalytic residue [active] 515618000430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515618000431 nucleotide binding region [chemical binding]; other site 515618000432 ATP-binding site [chemical binding]; other site 515618000433 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 515618000434 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 515618000435 ssDNA binding site; other site 515618000436 generic binding surface II; other site 515618000437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515618000438 ATP binding site [chemical binding]; other site 515618000439 putative Mg++ binding site [ion binding]; other site 515618000440 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 515618000441 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 515618000442 catalytic site [active] 515618000443 G-X2-G-X-G-K; other site 515618000444 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 515618000445 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 515618000446 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 515618000447 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 515618000448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515618000449 ATP binding site [chemical binding]; other site 515618000450 Mg2+ binding site [ion binding]; other site 515618000451 G-X-G motif; other site 515618000452 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 515618000453 anchoring element; other site 515618000454 dimer interface [polypeptide binding]; other site 515618000455 ATP binding site [chemical binding]; other site 515618000456 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 515618000457 active site 515618000458 putative metal-binding site [ion binding]; other site 515618000459 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 515618000460 DNA polymerase III subunit beta; Validated; Region: PRK05643 515618000461 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 515618000462 putative DNA binding surface [nucleotide binding]; other site 515618000463 dimer interface [polypeptide binding]; other site 515618000464 beta-clamp/clamp loader binding surface; other site 515618000465 beta-clamp/translesion DNA polymerase binding surface; other site 515618000466 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 515618000467 Ribonuclease P; Region: Ribonuclease_P; cl00457 515618000468 hypothetical protein; Validated; Region: PRK00041 515618000469 membrane protein insertase; Provisional; Region: PRK01318 515618000470 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 515618000471 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 515618000472 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 515618000473 trmE is a tRNA modification GTPase; Region: trmE; cd04164 515618000474 G1 box; other site 515618000475 GTP/Mg2+ binding site [chemical binding]; other site 515618000476 Switch I region; other site 515618000477 G2 box; other site 515618000478 Switch II region; other site 515618000479 G3 box; other site 515618000480 G4 box; other site 515618000481 G5 box; other site 515618000482 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 515618000483 hypothetical protein; Provisional; Region: PRK05208 515618000484 periplasmic folding chaperone; Provisional; Region: PRK10788 515618000485 SurA N-terminal domain; Region: SurA_N_3; cl07813 515618000486 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 515618000487 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 515618000488 Found in ATP-dependent protease La (LON); Region: LON; smart00464 515618000489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515618000490 Walker A motif; other site 515618000491 ATP binding site [chemical binding]; other site 515618000492 Walker B motif; other site 515618000493 arginine finger; other site 515618000494 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 515618000495 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 515618000496 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 515618000497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515618000498 Walker A motif; other site 515618000499 ATP binding site [chemical binding]; other site 515618000500 Walker B motif; other site 515618000501 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515618000502 Clp protease; Region: CLP_protease; pfam00574 515618000503 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 515618000504 oligomer interface [polypeptide binding]; other site 515618000505 active site residues [active] 515618000506 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 515618000507 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 515618000508 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 515618000509 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 515618000510 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 515618000511 D-pathway; other site 515618000512 Putative ubiquinol binding site [chemical binding]; other site 515618000513 Low-spin heme (heme b) binding site [chemical binding]; other site 515618000514 Putative water exit pathway; other site 515618000515 Binuclear center (heme o3/CuB) [ion binding]; other site 515618000516 K-pathway; other site 515618000517 Putative proton exit pathway; other site 515618000518 Subunit I/III interface [polypeptide binding]; other site 515618000519 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 515618000520 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 515618000521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515618000522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515618000523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515618000524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515618000525 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 515618000526 substrate binding pocket [chemical binding]; other site 515618000527 substrate-Mg2+ binding site; other site 515618000528 aspartate-rich region 1; other site 515618000529 aspartate-rich region 2; other site 515618000530 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 515618000531 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 515618000532 TPP-binding site; other site 515618000533 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515618000534 PYR/PP interface [polypeptide binding]; other site 515618000535 dimer interface [polypeptide binding]; other site 515618000536 TPP binding site [chemical binding]; other site 515618000537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515618000538 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 515618000539 tetramer interfaces [polypeptide binding]; other site 515618000540 binuclear metal-binding site [ion binding]; other site 515618000541 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 515618000542 putative RNA binding site [nucleotide binding]; other site 515618000543 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 515618000544 homopentamer interface [polypeptide binding]; other site 515618000545 active site 515618000546 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 515618000547 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 515618000548 catalytic motif [active] 515618000549 Zn binding site [ion binding]; other site 515618000550 RibD C-terminal domain; Region: RibD_C; cl17279 515618000551 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 515618000552 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 515618000553 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 515618000554 metal binding site [ion binding]; metal-binding site 515618000555 malic enzyme; Reviewed; Region: PRK12862 515618000556 Malic enzyme, N-terminal domain; Region: malic; pfam00390 515618000557 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 515618000558 putative NAD(P) binding site [chemical binding]; other site 515618000559 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 515618000560 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 515618000561 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 515618000562 adenylosuccinate lyase; Provisional; Region: PRK09285 515618000563 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 515618000564 tetramer interface [polypeptide binding]; other site 515618000565 active site 515618000566 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 515618000567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515618000568 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 515618000569 active site 515618000570 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 515618000571 rRNA binding site [nucleotide binding]; other site 515618000572 predicted 30S ribosome binding site; other site 515618000573 thioredoxin reductase; Provisional; Region: PRK10262 515618000574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515618000575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515618000576 seryl-tRNA synthetase; Provisional; Region: PRK05431 515618000577 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 515618000578 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 515618000579 dimer interface [polypeptide binding]; other site 515618000580 active site 515618000581 motif 1; other site 515618000582 motif 2; other site 515618000583 motif 3; other site 515618000584 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 515618000585 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515618000586 catalytic residue [active] 515618000587 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 515618000588 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 515618000589 hinge; other site 515618000590 active site 515618000591 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 515618000592 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 515618000593 RNA binding site [nucleotide binding]; other site 515618000594 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 515618000595 RNA binding site [nucleotide binding]; other site 515618000596 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 515618000597 RNA binding site [nucleotide binding]; other site 515618000598 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 515618000599 RNA binding site [nucleotide binding]; other site 515618000600 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 515618000601 RNA binding site [nucleotide binding]; other site 515618000602 Uncharacterized conserved protein [Function unknown]; Region: COG2835 515618000603 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 515618000604 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 515618000605 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 515618000606 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 515618000607 putative dimer interface [polypeptide binding]; other site 515618000608 putative anticodon binding site; other site 515618000609 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515618000610 motif 1; other site 515618000611 dimer interface [polypeptide binding]; other site 515618000612 active site 515618000613 motif 2; other site 515618000614 motif 3; other site 515618000615 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 515618000616 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 515618000617 active site 515618000618 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515618000619 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 515618000620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515618000621 active site 515618000622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515618000623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515618000624 Walker A/P-loop; other site 515618000625 ATP binding site [chemical binding]; other site 515618000626 Q-loop/lid; other site 515618000627 ABC transporter signature motif; other site 515618000628 Walker B; other site 515618000629 D-loop; other site 515618000630 H-loop/switch region; other site 515618000631 inner membrane transport permease; Provisional; Region: PRK15066 515618000632 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 515618000633 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 515618000634 catalytic center binding site [active] 515618000635 ATP binding site [chemical binding]; other site 515618000636 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 515618000637 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 515618000638 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 515618000639 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 515618000640 CTP synthetase; Validated; Region: pyrG; PRK05380 515618000641 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 515618000642 Catalytic site [active] 515618000643 active site 515618000644 UTP binding site [chemical binding]; other site 515618000645 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 515618000646 active site 515618000647 putative oxyanion hole; other site 515618000648 catalytic triad [active] 515618000649 enolase; Provisional; Region: eno; PRK00077 515618000650 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 515618000651 dimer interface [polypeptide binding]; other site 515618000652 metal binding site [ion binding]; metal-binding site 515618000653 substrate binding pocket [chemical binding]; other site 515618000654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 515618000655 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 515618000656 RNA/DNA hybrid binding site [nucleotide binding]; other site 515618000657 active site 515618000658 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 515618000659 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 515618000660 active site 515618000661 catalytic site [active] 515618000662 substrate binding site [chemical binding]; other site 515618000663 transketolase; Reviewed; Region: PRK12753 515618000664 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 515618000665 TPP-binding site [chemical binding]; other site 515618000666 dimer interface [polypeptide binding]; other site 515618000667 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515618000668 PYR/PP interface [polypeptide binding]; other site 515618000669 dimer interface [polypeptide binding]; other site 515618000670 TPP binding site [chemical binding]; other site 515618000671 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515618000672 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 515618000673 Phosphoglycerate kinase; Region: PGK; pfam00162 515618000674 substrate binding site [chemical binding]; other site 515618000675 hinge regions; other site 515618000676 ADP binding site [chemical binding]; other site 515618000677 catalytic site [active] 515618000678 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 515618000679 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 515618000680 active site 515618000681 intersubunit interface [polypeptide binding]; other site 515618000682 zinc binding site [ion binding]; other site 515618000683 Na+ binding site [ion binding]; other site 515618000684 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 515618000685 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000686 active site 515618000687 HIGH motif; other site 515618000688 nucleotide binding site [chemical binding]; other site 515618000689 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000690 active site 515618000691 KMSKS motif; other site 515618000692 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 515618000693 flavodoxin FldA; Validated; Region: PRK09267 515618000694 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 515618000695 Iron-sulfur protein interface; other site 515618000696 proximal quinone binding site [chemical binding]; other site 515618000697 SdhD (CybS) interface [polypeptide binding]; other site 515618000698 proximal heme binding site [chemical binding]; other site 515618000699 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 515618000700 proximal heme binding site [chemical binding]; other site 515618000701 Iron-sulfur protein interface; other site 515618000702 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 515618000703 L-aspartate oxidase; Provisional; Region: PRK06175 515618000704 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 515618000705 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 515618000706 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 515618000707 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 515618000708 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 515618000709 TPP-binding site [chemical binding]; other site 515618000710 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 515618000711 dimer interface [polypeptide binding]; other site 515618000712 PYR/PP interface [polypeptide binding]; other site 515618000713 TPP binding site [chemical binding]; other site 515618000714 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 515618000715 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347 515618000716 E3 interaction surface; other site 515618000717 lipoyl attachment site [posttranslational modification]; other site 515618000718 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 515618000719 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 515618000720 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 515618000721 CoA-ligase; Region: Ligase_CoA; pfam00549 515618000722 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 515618000723 CoA binding domain; Region: CoA_binding; smart00881 515618000724 CoA-ligase; Region: Ligase_CoA; pfam00549 515618000725 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515618000726 catalytic core [active] 515618000727 peroxiredoxin; Region: AhpC; TIGR03137 515618000728 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 515618000729 dimer interface [polypeptide binding]; other site 515618000730 decamer (pentamer of dimers) interface [polypeptide binding]; other site 515618000731 catalytic triad [active] 515618000732 peroxidatic and resolving cysteines [active] 515618000733 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 515618000734 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 515618000735 catalytic residues [active] 515618000736 transcription termination factor Rho; Provisional; Region: rho; PRK09376 515618000737 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 515618000738 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 515618000739 RNA binding site [nucleotide binding]; other site 515618000740 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 515618000741 multimer interface [polypeptide binding]; other site 515618000742 Walker A motif; other site 515618000743 ATP binding site [chemical binding]; other site 515618000744 Walker B motif; other site 515618000745 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 515618000746 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 515618000747 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 515618000748 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515618000749 Part of AAA domain; Region: AAA_19; pfam13245 515618000750 Family description; Region: UvrD_C_2; pfam13538 515618000751 putative hydrolase; Provisional; Region: PRK10976 515618000752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515618000753 active site 515618000754 motif I; other site 515618000755 motif II; other site 515618000756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515618000757 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 515618000758 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 515618000759 catalytic site [active] 515618000760 putative active site [active] 515618000761 putative substrate binding site [chemical binding]; other site 515618000762 dimer interface [polypeptide binding]; other site 515618000763 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 515618000764 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 515618000765 HflK protein; Region: hflK; TIGR01933 515618000766 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 515618000767 FtsH protease regulator HflC; Provisional; Region: PRK11029 515618000768 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 515618000769 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 515618000770 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 515618000771 GDP-binding site [chemical binding]; other site 515618000772 ACT binding site; other site 515618000773 IMP binding site; other site 515618000774 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 515618000775 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 515618000776 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 515618000777 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 515618000778 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 515618000779 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 515618000780 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 515618000781 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 515618000782 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 515618000783 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 515618000784 NAD binding site [chemical binding]; other site 515618000785 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 515618000786 multifunctional aminopeptidase A; Provisional; Region: PRK00913 515618000787 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 515618000788 interface (dimer of trimers) [polypeptide binding]; other site 515618000789 Substrate-binding/catalytic site; other site 515618000790 Zn-binding sites [ion binding]; other site 515618000791 Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525 515618000792 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000793 active site 515618000794 HIGH motif; other site 515618000795 nucleotide binding site [chemical binding]; other site 515618000796 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515618000797 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000798 active site 515618000799 KMSKS motif; other site 515618000800 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 515618000801 tRNA binding surface [nucleotide binding]; other site 515618000802 anticodon binding site; other site 515618000803 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 515618000804 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 515618000805 oligomer interface [polypeptide binding]; other site 515618000806 RNA binding site [nucleotide binding]; other site 515618000807 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 515618000808 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 515618000809 RNase E interface [polypeptide binding]; other site 515618000810 trimer interface [polypeptide binding]; other site 515618000811 active site 515618000812 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 515618000813 putative nucleic acid binding region [nucleotide binding]; other site 515618000814 G-X-X-G motif; other site 515618000815 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515618000816 RNA binding site [nucleotide binding]; other site 515618000817 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 515618000818 16S/18S rRNA binding site [nucleotide binding]; other site 515618000819 S13e-L30e interaction site [polypeptide binding]; other site 515618000820 Ribosome-binding factor A; Region: RBFA; pfam02033 515618000821 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 515618000822 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 515618000823 G1 box; other site 515618000824 putative GEF interaction site [polypeptide binding]; other site 515618000825 GTP/Mg2+ binding site [chemical binding]; other site 515618000826 Switch I region; other site 515618000827 G2 box; other site 515618000828 G3 box; other site 515618000829 Switch II region; other site 515618000830 G4 box; other site 515618000831 G5 box; other site 515618000832 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 515618000833 Translation-initiation factor 2; Region: IF-2; pfam11987 515618000834 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 515618000835 transcription termination factor NusA; Region: NusA; TIGR01953 515618000836 NusA N-terminal domain; Region: NusA_N; pfam08529 515618000837 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 515618000838 RNA binding site [nucleotide binding]; other site 515618000839 homodimer interface [polypeptide binding]; other site 515618000840 NusA-like KH domain; Region: KH_5; pfam13184 515618000841 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 515618000842 G-X-X-G motif; other site 515618000843 protein translocase, SecG subunit; Region: secG; TIGR00810 515618000844 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 515618000845 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 515618000846 active site 515618000847 substrate binding site [chemical binding]; other site 515618000848 metal binding site [ion binding]; metal-binding site 515618000849 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 515618000850 dihydropteroate synthase; Region: DHPS; TIGR01496 515618000851 substrate binding pocket [chemical binding]; other site 515618000852 dimer interface [polypeptide binding]; other site 515618000853 inhibitor binding site; inhibition site 515618000854 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 515618000855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515618000856 ATP binding site [chemical binding]; other site 515618000857 Walker A motif; other site 515618000858 Walker B motif; other site 515618000859 arginine finger; other site 515618000860 Peptidase family M41; Region: Peptidase_M41; pfam01434 515618000861 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 515618000862 FtsJ-like methyltransferase; Region: FtsJ; cl17430 515618000863 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 515618000864 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 515618000865 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 515618000866 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 515618000867 GTP1/OBG; Region: GTP1_OBG; pfam01018 515618000868 Obg GTPase; Region: Obg; cd01898 515618000869 G1 box; other site 515618000870 GTP/Mg2+ binding site [chemical binding]; other site 515618000871 Switch I region; other site 515618000872 G2 box; other site 515618000873 G3 box; other site 515618000874 Switch II region; other site 515618000875 G4 box; other site 515618000876 G5 box; other site 515618000877 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 515618000878 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 515618000879 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 515618000880 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 515618000881 substrate binding pocket [chemical binding]; other site 515618000882 chain length determination region; other site 515618000883 substrate-Mg2+ binding site; other site 515618000884 catalytic residues [active] 515618000885 aspartate-rich region 1; other site 515618000886 active site lid residues [active] 515618000887 aspartate-rich region 2; other site 515618000888 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 515618000889 dimer interface [polypeptide binding]; other site 515618000890 substrate binding site [chemical binding]; other site 515618000891 metal binding sites [ion binding]; metal-binding site 515618000892 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 515618000893 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515618000894 minor groove reading motif; other site 515618000895 helix-hairpin-helix signature motif; other site 515618000896 active site 515618000897 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 515618000898 dimerization interface [polypeptide binding]; other site 515618000899 active site 515618000900 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 515618000901 putative inner membrane peptidase; Provisional; Region: PRK11778 515618000902 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 515618000903 tandem repeat interface [polypeptide binding]; other site 515618000904 oligomer interface [polypeptide binding]; other site 515618000905 active site residues [active] 515618000906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515618000907 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 515618000908 NAD(P) binding site [chemical binding]; other site 515618000909 active site 515618000910 hypothetical protein; Provisional; Region: PRK02868 515618000911 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 515618000912 PLD-like domain; Region: PLDc_2; pfam13091 515618000913 putative active site [active] 515618000914 catalytic site [active] 515618000915 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 515618000916 PLD-like domain; Region: PLDc_2; pfam13091 515618000917 putative active site [active] 515618000918 catalytic site [active] 515618000919 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 515618000920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 515618000921 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 515618000922 Protein of unknown function (DUF721); Region: DUF721; cl02324 515618000923 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 515618000924 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 515618000925 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 515618000926 homodimer interface [polypeptide binding]; other site 515618000927 NADP binding site [chemical binding]; other site 515618000928 substrate binding site [chemical binding]; other site 515618000929 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 515618000930 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618000931 active site 515618000932 HIGH motif; other site 515618000933 nucleotide binding site [chemical binding]; other site 515618000934 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 515618000935 KMSKS motif; other site 515618000936 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 515618000937 tRNA binding surface [nucleotide binding]; other site 515618000938 anticodon binding site; other site 515618000939 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 515618000940 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 515618000941 adenylate kinase; Reviewed; Region: adk; PRK00279 515618000942 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 515618000943 AMP-binding site [chemical binding]; other site 515618000944 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 515618000945 heat shock protein 90; Provisional; Region: PRK05218 515618000946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515618000947 ATP binding site [chemical binding]; other site 515618000948 Mg2+ binding site [ion binding]; other site 515618000949 G-X-G motif; other site 515618000950 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 515618000951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515618000952 Walker A motif; other site 515618000953 ATP binding site [chemical binding]; other site 515618000954 Walker B motif; other site 515618000955 arginine finger; other site 515618000956 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 515618000957 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 515618000958 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 515618000959 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 515618000960 active site 515618000961 HIGH motif; other site 515618000962 KMSK motif region; other site 515618000963 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 515618000964 tRNA binding surface [nucleotide binding]; other site 515618000965 anticodon binding site; other site 515618000966 Methyltransferase domain; Region: Methyltransf_23; pfam13489 515618000967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618000968 S-adenosylmethionine binding site [chemical binding]; other site 515618000969 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 515618000970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618000971 S-adenosylmethionine binding site [chemical binding]; other site 515618000972 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 515618000973 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 515618000974 dimer interface [polypeptide binding]; other site 515618000975 anticodon binding site; other site 515618000976 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515618000977 motif 1; other site 515618000978 dimer interface [polypeptide binding]; other site 515618000979 active site 515618000980 motif 2; other site 515618000981 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515618000982 active site 515618000983 motif 3; other site 515618000984 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 515618000985 active site 515618000986 putative DNA-binding cleft [nucleotide binding]; other site 515618000987 dimer interface [polypeptide binding]; other site 515618000988 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 515618000989 oligomerisation interface [polypeptide binding]; other site 515618000990 mobile loop; other site 515618000991 roof hairpin; other site 515618000992 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 515618000993 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 515618000994 ring oligomerisation interface [polypeptide binding]; other site 515618000995 ATP/Mg binding site [chemical binding]; other site 515618000996 stacking interactions; other site 515618000997 hinge regions; other site 515618000998 translation elongation factor P; Region: efp; TIGR00038 515618000999 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 515618001000 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 515618001001 RNA binding site [nucleotide binding]; other site 515618001002 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515618001003 RNA binding site [nucleotide binding]; other site 515618001004 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 515618001005 SmpB-tmRNA interface; other site 515618001006 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 515618001007 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 515618001008 GrpE; Region: GrpE; pfam01025 515618001009 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 515618001010 dimer interface [polypeptide binding]; other site 515618001011 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 515618001012 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 515618001013 ligand binding site [chemical binding]; other site 515618001014 active site 515618001015 UGI interface [polypeptide binding]; other site 515618001016 catalytic site [active] 515618001017 GTP-binding protein LepA; Provisional; Region: PRK05433 515618001018 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 515618001019 G1 box; other site 515618001020 GTP/Mg2+ binding site [chemical binding]; other site 515618001021 G2 box; other site 515618001022 Switch I region; other site 515618001023 G3 box; other site 515618001024 Switch II region; other site 515618001025 G4 box; other site 515618001026 G5 box; other site 515618001027 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 515618001028 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 515618001029 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 515618001030 signal peptidase I; Provisional; Region: PRK10861 515618001031 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515618001032 Catalytic site [active] 515618001033 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515618001034 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 515618001035 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 515618001036 dimerization interface [polypeptide binding]; other site 515618001037 active site 515618001038 metal binding site [ion binding]; metal-binding site 515618001039 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 515618001040 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 515618001041 active site 515618001042 hydrophilic channel; other site 515618001043 dimerization interface [polypeptide binding]; other site 515618001044 catalytic residues [active] 515618001045 active site lid [active] 515618001046 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 515618001047 ferredoxin; Validated; Region: PRK07118 515618001048 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 515618001049 nucleoside/Zn binding site; other site 515618001050 dimer interface [polypeptide binding]; other site 515618001051 catalytic motif [active] 515618001052 NAD synthetase; Provisional; Region: PRK13981 515618001053 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 515618001054 active site 515618001055 catalytic triad [active] 515618001056 dimer interface [polypeptide binding]; other site 515618001057 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 515618001058 homodimer interface [polypeptide binding]; other site 515618001059 NAD binding pocket [chemical binding]; other site 515618001060 ATP binding pocket [chemical binding]; other site 515618001061 Mg binding site [ion binding]; other site 515618001062 active-site loop [active] 515618001063 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 515618001064 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 515618001065 dimer interface [polypeptide binding]; other site 515618001066 active site 515618001067 glycine-pyridoxal phosphate binding site [chemical binding]; other site 515618001068 folate binding site [chemical binding]; other site 515618001069 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 515618001070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515618001071 putative substrate translocation pore; other site 515618001072 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 515618001073 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 515618001074 active site 515618001075 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 515618001076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515618001077 FeS/SAM binding site; other site 515618001078 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 515618001079 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 515618001080 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 515618001081 histidyl-tRNA synthetase; Region: hisS; TIGR00442 515618001082 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 515618001083 dimer interface [polypeptide binding]; other site 515618001084 motif 1; other site 515618001085 active site 515618001086 motif 2; other site 515618001087 motif 3; other site 515618001088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 515618001089 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 515618001090 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 515618001091 G2 box; other site 515618001092 Switch I region; other site 515618001093 G3 box; other site 515618001094 Switch II region; other site 515618001095 GTP/Mg2+ binding site [chemical binding]; other site 515618001096 G4 box; other site 515618001097 G5 box; other site 515618001098 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 515618001099 G1 box; other site 515618001100 GTP/Mg2+ binding site [chemical binding]; other site 515618001101 G2 box; other site 515618001102 Switch I region; other site 515618001103 G3 box; other site 515618001104 Switch II region; other site 515618001105 G4 box; other site 515618001106 G5 box; other site 515618001107 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 515618001108 CoA-binding site [chemical binding]; other site 515618001109 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 515618001110 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 515618001111 dimer interface [polypeptide binding]; other site 515618001112 motif 1; other site 515618001113 active site 515618001114 motif 2; other site 515618001115 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 515618001116 putative deacylase active site [active] 515618001117 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515618001118 motif 3; other site 515618001119 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 515618001120 anticodon binding site; other site 515618001121 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 515618001122 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 515618001123 Ligand Binding Site [chemical binding]; other site 515618001124 TilS substrate binding domain; Region: TilS; pfam09179 515618001125 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 515618001126 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 515618001127 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 515618001128 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 515618001129 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 515618001130 putative active site [active] 515618001131 putative PHP Thumb interface [polypeptide binding]; other site 515618001132 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 515618001133 generic binding surface I; other site 515618001134 generic binding surface II; other site 515618001135 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 515618001136 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 515618001137 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515618001138 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515618001139 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515618001140 Surface antigen; Region: Bac_surface_Ag; pfam01103 515618001141 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 515618001142 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 515618001143 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 515618001144 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 515618001145 catalytic residue [active] 515618001146 putative FPP diphosphate binding site; other site 515618001147 putative FPP binding hydrophobic cleft; other site 515618001148 dimer interface [polypeptide binding]; other site 515618001149 putative IPP diphosphate binding site; other site 515618001150 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 515618001151 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 515618001152 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 515618001153 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 515618001154 ribosome recycling factor; Reviewed; Region: frr; PRK00083 515618001155 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 515618001156 hinge region; other site 515618001157 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 515618001158 putative nucleotide binding site [chemical binding]; other site 515618001159 uridine monophosphate binding site [chemical binding]; other site 515618001160 homohexameric interface [polypeptide binding]; other site 515618001161 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 515618001162 Elongation factor TS; Region: EF_TS; pfam00889 515618001163 Elongation factor TS; Region: EF_TS; pfam00889 515618001164 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 515618001165 rRNA interaction site [nucleotide binding]; other site 515618001166 S8 interaction site; other site 515618001167 putative laminin-1 binding site; other site 515618001168 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 515618001169 active site 515618001170 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 515618001171 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 515618001172 trimer interface [polypeptide binding]; other site 515618001173 active site 515618001174 substrate binding site [chemical binding]; other site 515618001175 CoA binding site [chemical binding]; other site 515618001176 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 515618001177 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 515618001178 active site 515618001179 metal binding site [ion binding]; metal-binding site 515618001180 thymidylate synthase; Reviewed; Region: thyA; PRK01827 515618001181 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 515618001182 dimerization interface [polypeptide binding]; other site 515618001183 active site 515618001184 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 515618001185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515618001186 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 515618001187 thiamine ABC transporter, permease protein; Region: thiP; TIGR01253 515618001188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515618001189 dimer interface [polypeptide binding]; other site 515618001190 conserved gate region; other site 515618001191 putative PBP binding loops; other site 515618001192 ABC-ATPase subunit interface; other site 515618001193 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 515618001194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515618001195 Walker A/P-loop; other site 515618001196 ATP binding site [chemical binding]; other site 515618001197 Q-loop/lid; other site 515618001198 ABC transporter signature motif; other site 515618001199 Walker B; other site 515618001200 D-loop; other site 515618001201 H-loop/switch region; other site 515618001202 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 515618001203 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 515618001204 putative metal binding site [ion binding]; other site 515618001205 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 515618001206 HSP70 interaction site [polypeptide binding]; other site 515618001207 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 515618001208 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 515618001209 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 515618001210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618001211 S-adenosylmethionine binding site [chemical binding]; other site 515618001212 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 515618001213 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515618001214 active site 515618001215 metal binding site [ion binding]; metal-binding site 515618001216 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 515618001217 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 515618001218 folate binding site [chemical binding]; other site 515618001219 NADP+ binding site [chemical binding]; other site 515618001220 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 515618001221 putative acyl-acceptor binding pocket; other site 515618001222 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 515618001223 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 515618001224 Membrane fusogenic activity; Region: BMFP; cl01115 515618001225 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 515618001226 triosephosphate isomerase; Provisional; Region: PRK14565 515618001227 substrate binding site [chemical binding]; other site 515618001228 dimer interface [polypeptide binding]; other site 515618001229 catalytic triad [active] 515618001230 ferredoxin-NADP reductase; Provisional; Region: PRK10926 515618001231 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 515618001232 FAD binding pocket [chemical binding]; other site 515618001233 FAD binding motif [chemical binding]; other site 515618001234 phosphate binding motif [ion binding]; other site 515618001235 beta-alpha-beta structure motif; other site 515618001236 NAD binding pocket [chemical binding]; other site 515618001237 glycerol kinase; Provisional; Region: glpK; PRK00047 515618001238 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 515618001239 N- and C-terminal domain interface [polypeptide binding]; other site 515618001240 active site 515618001241 MgATP binding site [chemical binding]; other site 515618001242 catalytic site [active] 515618001243 metal binding site [ion binding]; metal-binding site 515618001244 glycerol binding site [chemical binding]; other site 515618001245 homotetramer interface [polypeptide binding]; other site 515618001246 homodimer interface [polypeptide binding]; other site 515618001247 FBP binding site [chemical binding]; other site 515618001248 protein IIAGlc interface [polypeptide binding]; other site 515618001249 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 515618001250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515618001251 Walker A motif; other site 515618001252 ATP binding site [chemical binding]; other site 515618001253 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 515618001254 Walker B motif; other site 515618001255 arginine finger; other site 515618001256 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515618001257 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 515618001258 active site 515618001259 HslU subunit interaction site [polypeptide binding]; other site 515618001260 potential frameshift: common BLAST hit: gi|290477224|ref|YP_003470141.1| primosomal protein N' (factor Y) directs replication fork assembly 515618001261 primosomal protein N' Region: priA; TIGR00595 515618001262 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515618001263 ATP binding site [chemical binding]; other site 515618001264 putative Mg++ binding site [ion binding]; other site 515618001265 helicase superfamily c-terminal domain; Region: HELICc; smart00490 515618001266 nucleotide binding region [chemical binding]; other site 515618001267 ATP-binding site [chemical binding]; other site 515618001268 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 515618001269 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 515618001270 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 515618001271 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 515618001272 homodimer interface [polypeptide binding]; other site 515618001273 oligonucleotide binding site [chemical binding]; other site 515618001274 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 515618001275 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515618001276 RNA binding surface [nucleotide binding]; other site 515618001277 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515618001278 active site 515618001279 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 515618001280 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 515618001281 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 515618001282 dimer interface [polypeptide binding]; other site 515618001283 active site 515618001284 CoA binding pocket [chemical binding]; other site 515618001285 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 515618001286 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 515618001287 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 515618001288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515618001289 NAD(P) binding site [chemical binding]; other site 515618001290 active site 515618001291 acyl carrier protein; Provisional; Region: acpP; PRK00982 515618001292 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 515618001293 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 515618001294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515618001295 catalytic residue [active] 515618001296 thymidylate kinase; Validated; Region: tmk; PRK00698 515618001297 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 515618001298 TMP-binding site; other site 515618001299 ATP-binding site [chemical binding]; other site 515618001300 DNA polymerase III subunit delta'; Validated; Region: PRK07993 515618001301 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 515618001302 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 515618001303 active site 515618001304 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 515618001305 nucleotide binding site/active site [active] 515618001306 HIT family signature motif; other site 515618001307 catalytic residue [active] 515618001308 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 515618001309 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 515618001310 domain interface [polypeptide binding]; other site 515618001311 putative active site [active] 515618001312 catalytic site [active] 515618001313 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 515618001314 domain interface [polypeptide binding]; other site 515618001315 putative active site [active] 515618001316 catalytic site [active] 515618001317 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 515618001318 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 515618001319 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 515618001320 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 515618001321 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 515618001322 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 515618001323 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 515618001324 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 515618001325 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 515618001326 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 515618001327 DNA binding site [nucleotide binding] 515618001328 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 515618001329 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 515618001330 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 515618001331 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 515618001332 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 515618001333 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 515618001334 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 515618001335 RPB3 interaction site [polypeptide binding]; other site 515618001336 RPB1 interaction site [polypeptide binding]; other site 515618001337 RPB11 interaction site [polypeptide binding]; other site 515618001338 RPB10 interaction site [polypeptide binding]; other site 515618001339 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 515618001340 core dimer interface [polypeptide binding]; other site 515618001341 peripheral dimer interface [polypeptide binding]; other site 515618001342 L10 interface [polypeptide binding]; other site 515618001343 L11 interface [polypeptide binding]; other site 515618001344 putative EF-Tu interaction site [polypeptide binding]; other site 515618001345 putative EF-G interaction site [polypeptide binding]; other site 515618001346 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 515618001347 23S rRNA interface [nucleotide binding]; other site 515618001348 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 515618001349 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 515618001350 mRNA/rRNA interface [nucleotide binding]; other site 515618001351 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 515618001352 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 515618001353 putative thiostrepton binding site; other site 515618001354 23S rRNA interface [nucleotide binding]; other site 515618001355 L7/L12 interface [polypeptide binding]; other site 515618001356 L25 interface [polypeptide binding]; other site 515618001357 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 515618001358 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 515618001359 putative homodimer interface [polypeptide binding]; other site 515618001360 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 515618001361 heterodimer interface [polypeptide binding]; other site 515618001362 homodimer interface [polypeptide binding]; other site 515618001363 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 515618001364 elongation factor Tu; Reviewed; Region: PRK00049 515618001365 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 515618001366 G1 box; other site 515618001367 GEF interaction site [polypeptide binding]; other site 515618001368 GTP/Mg2+ binding site [chemical binding]; other site 515618001369 Switch I region; other site 515618001370 G2 box; other site 515618001371 G3 box; other site 515618001372 Switch II region; other site 515618001373 G4 box; other site 515618001374 G5 box; other site 515618001375 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 515618001376 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 515618001377 Antibiotic Binding Site [chemical binding]; other site 515618001378 pantothenate kinase; Provisional; Region: PRK05439 515618001379 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 515618001380 ATP-binding site [chemical binding]; other site 515618001381 CoA-binding site [chemical binding]; other site 515618001382 Mg2+-binding site [ion binding]; other site 515618001383 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 515618001384 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 515618001385 FAD binding domain; Region: FAD_binding_4; pfam01565 515618001386 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 515618001387 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 515618001388 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 515618001389 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 515618001390 shikimate binding site; other site 515618001391 NAD(P) binding site [chemical binding]; other site 515618001392 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 515618001393 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 515618001394 active site 515618001395 catalytic residues [active] 515618001396 metal binding site [ion binding]; metal-binding site 515618001397 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 515618001398 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 515618001399 putative active site [active] 515618001400 substrate binding site [chemical binding]; other site 515618001401 putative cosubstrate binding site; other site 515618001402 catalytic site [active] 515618001403 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 515618001404 substrate binding site [chemical binding]; other site 515618001405 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 515618001406 TrkA-N domain; Region: TrkA_N; pfam02254 515618001407 TrkA-C domain; Region: TrkA_C; pfam02080 515618001408 TrkA-N domain; Region: TrkA_N; pfam02254 515618001409 TrkA-C domain; Region: TrkA_C; pfam02080 515618001410 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 515618001411 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 515618001412 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 515618001413 alphaNTD homodimer interface [polypeptide binding]; other site 515618001414 alphaNTD - beta interaction site [polypeptide binding]; other site 515618001415 alphaNTD - beta' interaction site [polypeptide binding]; other site 515618001416 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 515618001417 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 515618001418 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 515618001419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515618001420 RNA binding surface [nucleotide binding]; other site 515618001421 30S ribosomal protein S11; Validated; Region: PRK05309 515618001422 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 515618001423 30S ribosomal protein S13; Region: bact_S13; TIGR03631 515618001424 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 515618001425 SecY translocase; Region: SecY; pfam00344 515618001426 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 515618001427 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 515618001428 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 515618001429 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 515618001430 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 515618001431 5S rRNA interface [nucleotide binding]; other site 515618001432 L27 interface [polypeptide binding]; other site 515618001433 23S rRNA interface [nucleotide binding]; other site 515618001434 L5 interface [polypeptide binding]; other site 515618001435 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 515618001436 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 515618001437 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 515618001438 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 515618001439 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 515618001440 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 515618001441 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 515618001442 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 515618001443 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 515618001444 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 515618001445 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 515618001446 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 515618001447 23S rRNA interface [nucleotide binding]; other site 515618001448 5S rRNA interface [nucleotide binding]; other site 515618001449 putative antibiotic binding site [chemical binding]; other site 515618001450 L25 interface [polypeptide binding]; other site 515618001451 L27 interface [polypeptide binding]; other site 515618001452 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 515618001453 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 515618001454 G-X-X-G motif; other site 515618001455 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 515618001456 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 515618001457 protein-rRNA interface [nucleotide binding]; other site 515618001458 putative translocon binding site; other site 515618001459 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 515618001460 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 515618001461 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 515618001462 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 515618001463 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 515618001464 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 515618001465 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 515618001466 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 515618001467 elongation factor G; Reviewed; Region: PRK00007 515618001468 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 515618001469 G1 box; other site 515618001470 putative GEF interaction site [polypeptide binding]; other site 515618001471 GTP/Mg2+ binding site [chemical binding]; other site 515618001472 Switch I region; other site 515618001473 G2 box; other site 515618001474 G3 box; other site 515618001475 Switch II region; other site 515618001476 G4 box; other site 515618001477 G5 box; other site 515618001478 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 515618001479 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 515618001480 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 515618001481 30S ribosomal protein S7; Validated; Region: PRK05302 515618001482 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 515618001483 S17 interaction site [polypeptide binding]; other site 515618001484 S8 interaction site; other site 515618001485 16S rRNA interaction site [nucleotide binding]; other site 515618001486 streptomycin interaction site [chemical binding]; other site 515618001487 23S rRNA interaction site [nucleotide binding]; other site 515618001488 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 515618001489 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 515618001490 Lumazine binding domain; Region: Lum_binding; pfam00677 515618001491 Lumazine binding domain; Region: Lum_binding; pfam00677 515618001492 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 515618001493 MviN-like protein; Region: MVIN; pfam03023 515618001494 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 515618001495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618001496 S-adenosylmethionine binding site [chemical binding]; other site 515618001497 This domain is found in peptide chain release factors; Region: PCRF; smart00937 515618001498 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 515618001499 RF-1 domain; Region: RF-1; pfam00472 515618001500 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 515618001501 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515618001502 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 515618001503 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 515618001504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515618001505 active site 515618001506 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 515618001507 putative active site [active] 515618001508 catalytic residue [active] 515618001509 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 515618001510 alanine racemase; Reviewed; Region: alr; PRK00053 515618001511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515618001512 catalytic residue [active] 515618001513 replicative DNA helicase; Provisional; Region: PRK08006 515618001514 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 515618001515 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 515618001516 Walker A motif; other site 515618001517 ATP binding site [chemical binding]; other site 515618001518 Walker B motif; other site 515618001519 DNA binding loops [nucleotide binding] 515618001520 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 515618001521 active site 1 [active] 515618001522 dimer interface [polypeptide binding]; other site 515618001523 active site 2 [active] 515618001524 DsrC like protein; Region: DsrC; pfam04358 515618001525 cell division protein FtsZ; Validated; Region: PRK09330 515618001526 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 515618001527 nucleotide binding site [chemical binding]; other site 515618001528 SulA interaction site; other site 515618001529 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 515618001530 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515618001531 Cell division protein FtsA; Region: FtsA; pfam14450 515618001532 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 515618001533 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 515618001534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515618001535 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 515618001536 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515618001537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515618001538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515618001539 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 515618001540 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 515618001541 homodimer interface [polypeptide binding]; other site 515618001542 active site 515618001543 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 515618001544 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 515618001545 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515618001546 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515618001547 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 515618001548 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 515618001549 Mg++ binding site [ion binding]; other site 515618001550 putative catalytic motif [active] 515618001551 putative substrate binding site [chemical binding]; other site 515618001552 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 515618001553 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515618001554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515618001555 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 515618001556 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515618001557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515618001558 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515618001559 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 515618001560 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 515618001561 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515618001562 MraW methylase family; Region: Methyltransf_5; cl17771 515618001563 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 515618001564 S-adenosylmethionine synthetase; Validated; Region: PRK05250 515618001565 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 515618001566 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 515618001567 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 515618001568 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 515618001569 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 515618001570 HIGH motif; other site 515618001571 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 515618001572 active site 515618001573 KMSKS motif; other site 515618001574 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 515618001575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515618001576 Walker A/P-loop; other site 515618001577 ATP binding site [chemical binding]; other site 515618001578 Q-loop/lid; other site 515618001579 ABC transporter signature motif; other site 515618001580 Walker B; other site 515618001581 D-loop; other site 515618001582 H-loop/switch region; other site 515618001583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515618001584 dimer interface [polypeptide binding]; other site 515618001585 conserved gate region; other site 515618001586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515618001587 ABC-ATPase subunit interface; other site 515618001588 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515618001589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515618001590 dimer interface [polypeptide binding]; other site 515618001591 conserved gate region; other site 515618001592 putative PBP binding loops; other site 515618001593 ABC-ATPase subunit interface; other site 515618001594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515618001595 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 515618001596 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 515618001597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 515618001598 S-adenosylmethionine binding site [chemical binding]; other site 515618001599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 515618001600 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 515618001601 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 515618001602 Tetramer interface [polypeptide binding]; other site 515618001603 active site 515618001604 FMN-binding site [chemical binding]; other site 515618001605 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 515618001606 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 515618001607 dimer interface [polypeptide binding]; other site 515618001608 active site 515618001609 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 515618001610 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 515618001611 ligand binding site [chemical binding]; other site 515618001612 NAD binding site [chemical binding]; other site 515618001613 catalytic site [active] 515618001614 homodimer interface [polypeptide binding]; other site 515618001615 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 515618001616 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 515618001617 dimerization interface 3.5A [polypeptide binding]; other site 515618001618 active site 515618001619 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 515618001620 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 515618001621 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 515618001622 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 515618001623 Flavoprotein; Region: Flavoprotein; pfam02441 515618001624 phosphate acetyltransferase; Reviewed; Region: PRK05632 515618001625 DRTGG domain; Region: DRTGG; pfam07085 515618001626 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 515618001627 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 515618001628 propionate/acetate kinase; Provisional; Region: PRK12379 515618001629 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 515618001630 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618001631 active site 515618001632 HIGH motif; other site 515618001633 nucleotide binding site [chemical binding]; other site 515618001634 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618001635 active site 515618001636 KMSKS motif; other site 515618001637 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 515618001638 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 515618001639 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 515618001640 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 515618001641 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 515618001642 active site 515618001643 dimer interface [polypeptide binding]; other site 515618001644 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 515618001645 dimer interface [polypeptide binding]; other site 515618001646 active site 515618001647 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 515618001648 UbiA prenyltransferase family; Region: UbiA; pfam01040 515618001649 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 515618001650 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 515618001651 putative acyl-acceptor binding pocket; other site 515618001652 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 515618001653 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 515618001654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515618001655 putative substrate translocation pore; other site 515618001656 POT family; Region: PTR2; cl17359 515618001657 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 515618001658 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 515618001659 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 515618001660 glutamate dehydrogenase; Provisional; Region: PRK09414 515618001661 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 515618001662 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 515618001663 NAD(P) binding pocket [chemical binding]; other site 515618001664 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 515618001665 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 515618001666 shikimate kinase; Reviewed; Region: aroK; PRK00131 515618001667 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 515618001668 ADP binding site [chemical binding]; other site 515618001669 magnesium binding site [ion binding]; other site 515618001670 putative shikimate binding site; other site 515618001671 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 515618001672 active site 515618001673 dimer interface [polypeptide binding]; other site 515618001674 metal binding site [ion binding]; metal-binding site 515618001675 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 515618001676 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 515618001677 substrate binding site [chemical binding]; other site 515618001678 hexamer interface [polypeptide binding]; other site 515618001679 metal binding site [ion binding]; metal-binding site 515618001680 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 515618001681 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 515618001682 active site 515618001683 HIGH motif; other site 515618001684 dimer interface [polypeptide binding]; other site 515618001685 KMSKS motif; other site 515618001686 superoxide dismutase; Provisional; Region: PRK10925 515618001687 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 515618001688 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 515618001689 Cation transport protein; Region: TrkH; cl17365 515618001690 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 515618001691 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 515618001692 ABC1 family; Region: ABC1; cl17513 515618001693 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 515618001694 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 515618001695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618001696 S-adenosylmethionine binding site [chemical binding]; other site 515618001697 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 515618001698 substrate binding site [chemical binding]; other site 515618001699 nucleotide binding site [chemical binding]; other site 515618001700 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 515618001701 nucleotide binding site [chemical binding]; other site 515618001702 transaldolase-like protein; Provisional; Region: PTZ00411 515618001703 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 515618001704 active site 515618001705 dimer interface [polypeptide binding]; other site 515618001706 catalytic residue [active] 515618001707 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 515618001708 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515618001709 nucleotide binding site [chemical binding]; other site 515618001710 chaperone protein DnaJ; Provisional; Region: PRK10767 515618001711 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 515618001712 HSP70 interaction site [polypeptide binding]; other site 515618001713 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 515618001714 substrate binding site [polypeptide binding]; other site 515618001715 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 515618001716 Zn binding sites [ion binding]; other site 515618001717 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 515618001718 dimer interface [polypeptide binding]; other site 515618001719 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 515618001720 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 515618001721 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 515618001722 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 515618001723 active site 515618001724 Riboflavin kinase; Region: Flavokinase; smart00904 515618001725 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 515618001726 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618001727 active site 515618001728 HIGH motif; other site 515618001729 nucleotide binding site [chemical binding]; other site 515618001730 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515618001731 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 515618001732 active site 515618001733 KMSKS motif; other site 515618001734 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 515618001735 tRNA binding surface [nucleotide binding]; other site 515618001736 anticodon binding site; other site 515618001737 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 515618001738 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 515618001739 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 515618001740 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 515618001741 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 515618001742 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 515618001743 Peptidase family M23; Region: Peptidase_M23; pfam01551 515618001744 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 515618001745 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 515618001746 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 515618001747 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 515618001748 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 515618001749 dimerization domain swap beta strand [polypeptide binding]; other site 515618001750 regulatory protein interface [polypeptide binding]; other site 515618001751 active site 515618001752 regulatory phosphorylation site [posttranslational modification]; other site 515618001753 Ligase N family; Region: LIGANc; smart00532 515618001754 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 515618001755 nucleotide binding pocket [chemical binding]; other site 515618001756 K-X-D-G motif; other site 515618001757 catalytic site [active] 515618001758 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 515618001759 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 515618001760 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 515618001761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 515618001762 inhibitor-cofactor binding pocket; inhibition site 515618001763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515618001764 catalytic residue [active] 515618001765 biotin synthase; Provisional; Region: PRK15108 515618001766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515618001767 FeS/SAM binding site; other site 515618001768 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 515618001769 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 515618001770 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 515618001771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515618001772 catalytic residue [active] 515618001773 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 515618001774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515618001775 S-adenosylmethionine binding site [chemical binding]; other site 515618001776 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 515618001777 AAA domain; Region: AAA_26; pfam13500 515618001778 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 515618001779 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 515618001780 threonine and homoserine efflux system; Provisional; Region: PRK10532 515618001781 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 515618001782 active site 515618001783 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 515618001784 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 515618001785 active site 515618001786 HIGH motif; other site 515618001787 KMSKS motif; other site 515618001788 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 515618001789 anticodon binding site; other site 515618001790 tRNA binding surface [nucleotide binding]; other site 515618001791 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 515618001792 trimer interface [polypeptide binding]; other site 515618001793 active site 515618001794 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 515618001795 FOG: CBS domain [General function prediction only]; Region: COG0517 515618001796 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 515618001797 Transporter associated domain; Region: CorC_HlyC; smart01091 515618001798 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 515618001799 motif 1; other site 515618001800 dimer interface [polypeptide binding]; other site 515618001801 active site 515618001802 motif 2; other site 515618001803 motif 3; other site 515618001804 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 515618001805 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 515618001806 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 515618001807 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 515618001808 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 515618001809 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 515618001810 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 515618001811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515618001812 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 515618001813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515618001814 DNA binding residues [nucleotide binding] 515618001815 DNA primase; Validated; Region: dnaG; PRK05667 515618001816 CHC2 zinc finger; Region: zf-CHC2; pfam01807 515618001817 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 515618001818 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 515618001819 active site 515618001820 metal binding site [ion binding]; metal-binding site 515618001821 interdomain interaction site; other site 515618001822 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 515618001823 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 515618001824 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 515618001825 UGMP family protein; Validated; Region: PRK09604 515618001826 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 515618001827 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 515618001828 active site 515618001829 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 515618001830 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 515618001831 active site 515618001832 NTP binding site [chemical binding]; other site 515618001833 metal binding triad [ion binding]; metal-binding site 515618001834 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 515618001835 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 515618001836 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 515618001837 putative ribose interaction site [chemical binding]; other site 515618001838 putative ADP binding site [chemical binding]; other site 515618001839 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618001840 active site 515618001841 HIGH motif; other site 515618001842 nucleotide binding site [chemical binding]; other site 515618001843 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 515618001844 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 515618001845 dimer interface [polypeptide binding]; other site 515618001846 ssDNA binding site [nucleotide binding]; other site 515618001847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515618001848 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 515618001849 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 515618001850 dimer interface [polypeptide binding]; other site 515618001851 ssDNA binding site [nucleotide binding]; other site 515618001852 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515618001853 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 515618001854 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 515618001855 putative ribose interaction site [chemical binding]; other site 515618001856 putative ADP binding site [chemical binding]; other site 515618001857 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515618001858 active site 515618001859 HIGH motif; other site 515618001860 nucleotide binding site [chemical binding]; other site 515618001861 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 515618001862 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 515618001863 active site 515618001864 NTP binding site [chemical binding]; other site 515618001865 metal binding triad [ion binding]; metal-binding site 515618001866 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 515618001867 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 515618001868 active site 515618001869 UGMP family protein; Validated; Region: PRK09604 515618001870 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 515618001871 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 515618001872 DNA primase; Validated; Region: dnaG; PRK05667 515618001873 CHC2 zinc finger; Region: zf-CHC2; pfam01807 515618001874 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 515618001875 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 515618001876 active site 515618001877 metal binding site [ion binding]; metal-binding site 515618001878 interdomain interaction site; other site 515618001879 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 515618001880 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 515618001881 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 515618001882 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 515618001883 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 515618001884 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 515618001885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515618001886 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 515618001887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515618001888 DNA binding residues [nucleotide binding]