-- dump date 20140619_025203 -- class Genbank::misc_feature -- table misc_feature_note -- id note 234267000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 234267000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 234267000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267000004 Walker A motif; other site 234267000005 ATP binding site [chemical binding]; other site 234267000006 Walker B motif; other site 234267000007 arginine finger; other site 234267000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 234267000009 DnaA box-binding interface [nucleotide binding]; other site 234267000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 234267000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 234267000012 putative DNA binding surface [nucleotide binding]; other site 234267000013 dimer interface [polypeptide binding]; other site 234267000014 beta-clamp/clamp loader binding surface; other site 234267000015 beta-clamp/translesion DNA polymerase binding surface; other site 234267000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 234267000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267000018 ATP binding site [chemical binding]; other site 234267000019 Mg2+ binding site [ion binding]; other site 234267000020 G-X-G motif; other site 234267000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 234267000022 anchoring element; other site 234267000023 dimer interface [polypeptide binding]; other site 234267000024 ATP binding site [chemical binding]; other site 234267000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 234267000026 active site 234267000027 putative metal-binding site [ion binding]; other site 234267000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 234267000029 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267000030 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 234267000031 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 234267000032 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267000033 metal binding site [ion binding]; metal-binding site 234267000034 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 234267000035 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 234267000036 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 234267000037 Cu(I) binding site [ion binding]; other site 234267000038 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267000039 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267000040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267000041 S-adenosylmethionine binding site [chemical binding]; other site 234267000042 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 234267000043 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267000044 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 234267000045 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 234267000046 active site 234267000047 PHP Thumb interface [polypeptide binding]; other site 234267000048 metal binding site [ion binding]; metal-binding site 234267000049 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 234267000050 generic binding surface I; other site 234267000051 generic binding surface II; other site 234267000052 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267000053 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267000054 FtsX-like permease family; Region: FtsX; pfam02687 234267000055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267000056 FtsX-like permease family; Region: FtsX; pfam02687 234267000057 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 234267000058 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 234267000059 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 234267000060 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 234267000061 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 234267000062 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 234267000063 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 234267000064 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 234267000065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234267000066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234267000067 P-loop; other site 234267000068 Magnesium ion binding site [ion binding]; other site 234267000069 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234267000070 Magnesium ion binding site [ion binding]; other site 234267000071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267000072 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 234267000073 ParB-like nuclease domain; Region: ParB; smart00470 234267000074 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 234267000075 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267000076 DNA binding residues [nucleotide binding] 234267000077 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 234267000078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000079 binding surface 234267000080 TPR motif; other site 234267000081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000082 TPR motif; other site 234267000083 binding surface 234267000084 CHASE3 domain; Region: CHASE3; pfam05227 234267000085 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 234267000086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267000087 PAS domain; Region: PAS_9; pfam13426 234267000088 putative active site [active] 234267000089 heme pocket [chemical binding]; other site 234267000090 PAS fold; Region: PAS; pfam00989 234267000091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267000092 putative active site [active] 234267000093 heme pocket [chemical binding]; other site 234267000094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267000095 PAS domain; Region: PAS_9; pfam13426 234267000096 putative active site [active] 234267000097 heme pocket [chemical binding]; other site 234267000098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267000099 dimer interface [polypeptide binding]; other site 234267000100 phosphorylation site [posttranslational modification] 234267000101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267000102 ATP binding site [chemical binding]; other site 234267000103 Mg2+ binding site [ion binding]; other site 234267000104 G-X-G motif; other site 234267000105 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267000106 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267000107 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267000108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267000109 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267000110 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267000111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267000112 active site 234267000113 ATP binding site [chemical binding]; other site 234267000114 substrate binding site [chemical binding]; other site 234267000115 activation loop (A-loop); other site 234267000116 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267000117 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267000118 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267000119 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267000120 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 234267000121 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 234267000122 folate binding site [chemical binding]; other site 234267000123 NADP+ binding site [chemical binding]; other site 234267000124 RibD C-terminal domain; Region: RibD_C; cl17279 234267000125 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267000126 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267000127 AP (apurinic/apyrimidinic) site pocket; other site 234267000128 Metal-binding active site; metal-binding site 234267000129 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 234267000130 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 234267000131 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 234267000132 Part of AAA domain; Region: AAA_19; pfam13245 234267000133 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 234267000134 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 234267000135 Family description; Region: UvrD_C_2; pfam13538 234267000136 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 234267000137 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234267000138 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267000139 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234267000140 iron-sulfur cluster [ion binding]; other site 234267000141 [2Fe-2S] cluster binding site [ion binding]; other site 234267000142 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267000143 Peptidase S46; Region: Peptidase_S46; pfam10459 234267000144 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000145 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267000146 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267000147 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 234267000148 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234267000149 NAD binding site [chemical binding]; other site 234267000150 catalytic residues [active] 234267000151 substrate binding site [chemical binding]; other site 234267000152 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 234267000153 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 234267000154 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 234267000155 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 234267000156 NAD(P) binding site [chemical binding]; other site 234267000157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234267000158 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234267000159 active site 234267000160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267000161 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267000162 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 234267000163 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 234267000164 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 234267000165 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267000166 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267000167 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 234267000168 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 234267000169 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 234267000170 Walker A motif; other site 234267000171 ATP binding site [chemical binding]; other site 234267000172 Walker B motif; other site 234267000173 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 234267000174 cytidylate kinase; Provisional; Region: cmk; PRK00023 234267000175 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 234267000176 CMP-binding site; other site 234267000177 The sites determining sugar specificity; other site 234267000178 aspartate kinase; Provisional; Region: PRK06291 234267000179 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 234267000180 putative catalytic residues [active] 234267000181 nucleotide binding site [chemical binding]; other site 234267000182 aspartate binding site [chemical binding]; other site 234267000183 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 234267000184 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 234267000185 SurA N-terminal domain; Region: SurA_N_3; cl07813 234267000186 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 234267000187 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 234267000188 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 234267000189 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 234267000190 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 234267000191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267000192 active site 234267000193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267000194 aspartate aminotransferase; Provisional; Region: PRK06836 234267000195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267000196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267000197 homodimer interface [polypeptide binding]; other site 234267000198 catalytic residue [active] 234267000199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267000200 D-galactonate transporter; Region: 2A0114; TIGR00893 234267000201 putative substrate translocation pore; other site 234267000202 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234267000203 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234267000204 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 234267000205 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 234267000206 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 234267000207 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 234267000208 putative active site [active] 234267000209 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267000210 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267000211 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267000212 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267000213 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267000214 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 234267000215 Predicted methyltransferases [General function prediction only]; Region: COG0313 234267000216 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 234267000217 putative SAM binding site [chemical binding]; other site 234267000218 putative homodimer interface [polypeptide binding]; other site 234267000219 glutamine synthetase, type I; Region: GlnA; TIGR00653 234267000220 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 234267000221 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234267000222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 234267000223 MOSC domain; Region: MOSC; pfam03473 234267000224 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234267000225 metal binding triad; other site 234267000226 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 234267000227 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234267000228 metal binding triad; other site 234267000229 GAF domain; Region: GAF_3; pfam13492 234267000230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267000231 dimer interface [polypeptide binding]; other site 234267000232 phosphorylation site [posttranslational modification] 234267000233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267000234 ATP binding site [chemical binding]; other site 234267000235 Mg2+ binding site [ion binding]; other site 234267000236 G-X-G motif; other site 234267000237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267000238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267000239 active site 234267000240 phosphorylation site [posttranslational modification] 234267000241 intermolecular recognition site; other site 234267000242 dimerization interface [polypeptide binding]; other site 234267000243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267000244 DNA binding site [nucleotide binding] 234267000245 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 234267000246 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 234267000247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234267000248 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234267000249 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 234267000250 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 234267000251 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 234267000252 Ligand Binding Site [chemical binding]; other site 234267000253 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 234267000254 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 234267000255 Ligand Binding Site [chemical binding]; other site 234267000256 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 234267000257 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267000258 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267000259 Walker A/P-loop; other site 234267000260 ATP binding site [chemical binding]; other site 234267000261 Q-loop/lid; other site 234267000262 ABC transporter signature motif; other site 234267000263 Walker B; other site 234267000264 D-loop; other site 234267000265 H-loop/switch region; other site 234267000266 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267000267 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267000268 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267000269 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267000270 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267000271 active site 234267000272 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267000273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267000274 active site 234267000275 metal binding site [ion binding]; metal-binding site 234267000276 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 234267000277 PLD-like domain; Region: PLDc_2; pfam13091 234267000278 putative active site [active] 234267000279 putative catalytic site [active] 234267000280 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 234267000281 PLD-like domain; Region: PLDc_2; pfam13091 234267000282 putative active site [active] 234267000283 putative catalytic site [active] 234267000284 XFP N-terminal domain; Region: XFP_N; pfam09364 234267000285 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267000286 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267000287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267000288 Walker A/P-loop; other site 234267000289 ATP binding site [chemical binding]; other site 234267000290 Q-loop/lid; other site 234267000291 ABC transporter signature motif; other site 234267000292 Walker B; other site 234267000293 D-loop; other site 234267000294 H-loop/switch region; other site 234267000295 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267000296 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267000297 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 234267000298 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 234267000299 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 234267000300 active site 234267000301 catalytic triad [active] 234267000302 oxyanion hole [active] 234267000303 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 234267000304 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 234267000305 Carboxylesterase family; Region: COesterase; pfam00135 234267000306 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267000307 substrate binding pocket [chemical binding]; other site 234267000308 catalytic triad [active] 234267000309 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 234267000310 Ferredoxin [Energy production and conversion]; Region: COG1146 234267000311 4Fe-4S binding domain; Region: Fer4_6; pfam12837 234267000312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234267000313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234267000314 active site 234267000315 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 234267000316 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267000317 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267000318 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 234267000319 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267000320 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 234267000321 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234267000322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267000323 putative substrate translocation pore; other site 234267000324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267000325 TPR repeat; Region: TPR_11; pfam13414 234267000326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000327 binding surface 234267000328 TPR motif; other site 234267000329 TPR repeat; Region: TPR_11; pfam13414 234267000330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000331 TPR motif; other site 234267000332 binding surface 234267000333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267000334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000335 TPR repeat; Region: TPR_11; pfam13414 234267000336 binding surface 234267000337 TPR motif; other site 234267000338 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000339 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234267000340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 234267000341 ATP binding site [chemical binding]; other site 234267000342 Mg2+ binding site [ion binding]; other site 234267000343 G-X-G motif; other site 234267000344 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267000345 anti sigma factor interaction site; other site 234267000346 regulatory phosphorylation site [posttranslational modification]; other site 234267000347 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 234267000348 thiS-thiF/thiG interaction site; other site 234267000349 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 234267000350 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 234267000351 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 234267000352 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 234267000353 NADH dehydrogenase subunit D; Validated; Region: PRK06075 234267000354 NADH dehydrogenase subunit E; Validated; Region: PRK07539 234267000355 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 234267000356 putative dimer interface [polypeptide binding]; other site 234267000357 [2Fe-2S] cluster binding site [ion binding]; other site 234267000358 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 234267000359 SLBB domain; Region: SLBB; pfam10531 234267000360 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 234267000361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267000362 catalytic loop [active] 234267000363 iron binding site [ion binding]; other site 234267000364 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 234267000365 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 234267000366 4Fe-4S binding domain; Region: Fer4; pfam00037 234267000367 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267000368 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267000369 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267000370 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 234267000371 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 234267000372 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 234267000373 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 234267000374 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 234267000375 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 234267000376 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267000377 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 234267000378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267000379 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 234267000380 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267000381 TPR repeat; Region: TPR_11; pfam13414 234267000382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000383 binding surface 234267000384 TPR motif; other site 234267000385 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267000386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000387 binding surface 234267000388 TPR motif; other site 234267000389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000390 TPR motif; other site 234267000391 binding surface 234267000392 TPR repeat; Region: TPR_11; pfam13414 234267000393 TPR repeat; Region: TPR_11; pfam13414 234267000394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000395 binding surface 234267000396 TPR motif; other site 234267000397 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000398 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 234267000399 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 234267000400 N-terminal plug; other site 234267000401 ligand-binding site [chemical binding]; other site 234267000402 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 234267000403 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 234267000404 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 234267000405 Ligand Binding Site [chemical binding]; other site 234267000406 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 234267000407 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234267000408 cobalamin binding residues [chemical binding]; other site 234267000409 putative BtuC binding residues; other site 234267000410 dimer interface [polypeptide binding]; other site 234267000411 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 234267000412 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234267000413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267000414 active site 234267000415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267000416 active site 234267000417 phosphorylation site [posttranslational modification] 234267000418 intermolecular recognition site; other site 234267000419 dimerization interface [polypeptide binding]; other site 234267000420 hypothetical protein; Provisional; Region: PRK08201 234267000421 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 234267000422 metal binding site [ion binding]; metal-binding site 234267000423 putative dimer interface [polypeptide binding]; other site 234267000424 Sm and related proteins; Region: Sm_like; cl00259 234267000425 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 234267000426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000427 TPR motif; other site 234267000428 TPR repeat; Region: TPR_11; pfam13414 234267000429 binding surface 234267000430 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234267000431 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267000432 Probable Catalytic site; other site 234267000433 metal-binding site 234267000434 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267000435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267000436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267000437 DNA binding residues [nucleotide binding] 234267000438 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 234267000439 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000440 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267000441 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 234267000442 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 234267000443 active site 234267000444 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 234267000445 E-class dimer interface [polypeptide binding]; other site 234267000446 P-class dimer interface [polypeptide binding]; other site 234267000447 active site 234267000448 Cu2+ binding site [ion binding]; other site 234267000449 Zn2+ binding site [ion binding]; other site 234267000450 Predicted membrane protein [Function unknown]; Region: COG2259 234267000451 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234267000452 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267000453 Coenzyme A binding pocket [chemical binding]; other site 234267000454 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234267000455 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267000456 Flagellin N-methylase; Region: FliB; pfam03692 234267000457 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 234267000458 Phage Tail Collar Domain; Region: Collar; pfam07484 234267000459 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 234267000460 Phage Tail Collar Domain; Region: Collar; pfam07484 234267000461 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 234267000462 Phage Tail Collar Domain; Region: Collar; pfam07484 234267000463 MG2 domain; Region: A2M_N; pfam01835 234267000464 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 234267000465 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 234267000466 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 234267000467 putative active site [active] 234267000468 putative substrate binding site [chemical binding]; other site 234267000469 putative cosubstrate binding site; other site 234267000470 catalytic site [active] 234267000471 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 234267000472 generic binding surface I; other site 234267000473 generic binding surface II; other site 234267000474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267000475 PAS fold; Region: PAS_3; pfam08447 234267000476 putative active site [active] 234267000477 heme pocket [chemical binding]; other site 234267000478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267000479 dimer interface [polypeptide binding]; other site 234267000480 phosphorylation site [posttranslational modification] 234267000481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267000482 ATP binding site [chemical binding]; other site 234267000483 Mg2+ binding site [ion binding]; other site 234267000484 G-X-G motif; other site 234267000485 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267000487 active site 234267000488 phosphorylation site [posttranslational modification] 234267000489 intermolecular recognition site; other site 234267000490 dimerization interface [polypeptide binding]; other site 234267000491 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 234267000492 ACT domain-containing protein [General function prediction only]; Region: COG1707 234267000493 N-terminal ACT domain of the yet uncharacterized, small (; 133 a.a.), putative amino acid binding protein, Af1403, and related domains; Region: ACT_Af1403; cd04874 234267000494 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 234267000495 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267000496 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267000497 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267000498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267000499 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 234267000500 Zn binding site [ion binding]; other site 234267000501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267000502 dimer interface [polypeptide binding]; other site 234267000503 phosphorylation site [posttranslational modification] 234267000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267000505 ATP binding site [chemical binding]; other site 234267000506 Mg2+ binding site [ion binding]; other site 234267000507 G-X-G motif; other site 234267000508 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267000509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267000510 active site 234267000511 phosphorylation site [posttranslational modification] 234267000512 intermolecular recognition site; other site 234267000513 dimerization interface [polypeptide binding]; other site 234267000514 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 234267000515 CoA binding domain; Region: CoA_binding_2; pfam13380 234267000516 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 234267000517 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 234267000518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234267000519 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267000520 CCC1; Region: CCC1; cd02435 234267000521 methionine sulfoxide reductase B; Provisional; Region: PRK00222 234267000522 SelR domain; Region: SelR; pfam01641 234267000523 Uncharacterized conserved protein [Function unknown]; Region: COG2006 234267000524 Domain of unknown function (DUF362); Region: DUF362; pfam04015 234267000525 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 234267000526 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267000527 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267000528 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267000529 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267000530 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267000531 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267000532 metal ion-dependent adhesion site (MIDAS); other site 234267000533 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 234267000534 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267000535 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 234267000536 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 234267000537 active site 234267000538 catalytic residues [active] 234267000539 metal binding site [ion binding]; metal-binding site 234267000540 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 234267000541 ketol-acid reductoisomerase; Provisional; Region: PRK05479 234267000542 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 234267000543 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 234267000544 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 234267000545 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 234267000546 putative valine binding site [chemical binding]; other site 234267000547 dimer interface [polypeptide binding]; other site 234267000548 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 234267000549 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 234267000550 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234267000551 PYR/PP interface [polypeptide binding]; other site 234267000552 dimer interface [polypeptide binding]; other site 234267000553 TPP binding site [chemical binding]; other site 234267000554 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267000555 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 234267000556 TPP-binding site [chemical binding]; other site 234267000557 dimer interface [polypeptide binding]; other site 234267000558 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 234267000559 active site 234267000560 SAM binding site [chemical binding]; other site 234267000561 homodimer interface [polypeptide binding]; other site 234267000562 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 234267000563 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 234267000564 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 234267000565 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 234267000566 [4Fe-4S] binding site [ion binding]; other site 234267000567 molybdopterin cofactor binding site; other site 234267000568 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 234267000569 molybdopterin cofactor binding site; other site 234267000570 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 234267000571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267000572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267000573 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 234267000574 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234267000575 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 234267000576 [2Fe-2S] cluster binding site [ion binding]; other site 234267000577 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 234267000578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267000579 putative substrate translocation pore; other site 234267000580 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 234267000581 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 234267000582 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234267000583 active site 234267000584 RES domain; Region: RES; pfam08808 234267000585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267000586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267000587 putative substrate translocation pore; other site 234267000588 N-acetylneuraminate lyase; Provisional; Region: PRK04147 234267000589 Class I aldolases; Region: Aldolase_Class_I; cl17187 234267000590 catalytic residue [active] 234267000591 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 234267000592 catalytic site [active] 234267000593 BNR repeat-like domain; Region: BNR_2; pfam13088 234267000594 Asp-box motif; other site 234267000595 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000596 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267000597 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267000598 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234267000599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267000600 DNA-binding site [nucleotide binding]; DNA binding site 234267000601 FCD domain; Region: FCD; pfam07729 234267000602 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000603 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 234267000604 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 234267000605 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234267000606 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267000607 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 234267000608 Protein of unknown function, DUF608; Region: DUF608; pfam04685 234267000609 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000610 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267000611 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267000612 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 234267000613 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 234267000614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267000615 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 234267000616 putative dimerization interface [polypeptide binding]; other site 234267000617 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267000618 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 234267000619 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267000620 conserved cys residue [active] 234267000621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000622 TPR motif; other site 234267000623 binding surface 234267000624 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267000625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000626 TPR motif; other site 234267000627 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267000628 binding surface 234267000629 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267000630 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 234267000631 heme-binding residues [chemical binding]; other site 234267000632 TPR repeat; Region: TPR_11; pfam13414 234267000633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000634 binding surface 234267000635 TPR motif; other site 234267000636 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267000637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000638 binding surface 234267000639 TPR repeat; Region: TPR_11; pfam13414 234267000640 TPR motif; other site 234267000641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000642 binding surface 234267000643 TPR motif; other site 234267000644 Family description; Region: VCBS; pfam13517 234267000645 Family description; Region: VCBS; pfam13517 234267000646 Family description; Region: VCBS; pfam13517 234267000647 Family description; Region: VCBS; pfam13517 234267000648 Family description; Region: VCBS; pfam13517 234267000649 Family description; Region: VCBS; pfam13517 234267000650 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267000651 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 234267000652 Uncharacterized conserved protein [Function unknown]; Region: COG1656 234267000653 Protein of unknown function DUF82; Region: DUF82; pfam01927 234267000654 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 234267000655 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 234267000656 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 234267000657 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 234267000658 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 234267000659 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 234267000660 catalytic site [active] 234267000661 active site 234267000662 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 234267000663 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 234267000664 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 234267000665 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 234267000666 active site 234267000667 catalytic site [active] 234267000668 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 234267000669 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 234267000670 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 234267000671 active site 234267000672 catalytic site [active] 234267000673 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267000674 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267000675 active site 234267000676 ATP binding site [chemical binding]; other site 234267000677 substrate binding site [chemical binding]; other site 234267000678 activation loop (A-loop); other site 234267000679 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 234267000680 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 234267000681 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 234267000682 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 234267000683 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 234267000684 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 234267000685 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 234267000686 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 234267000687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267000688 S-adenosylmethionine binding site [chemical binding]; other site 234267000689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267000690 S-adenosylmethionine binding site [chemical binding]; other site 234267000691 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267000692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267000693 S-adenosylmethionine binding site [chemical binding]; other site 234267000694 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 234267000695 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 234267000696 Protein of unknown function (DUF770); Region: DUF770; pfam05591 234267000697 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 234267000698 Protein of unknown function (DUF877); Region: DUF877; pfam05943 234267000699 Protein of unknown function (DUF796); Region: DUF796; pfam05638 234267000700 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 234267000701 ImpE protein; Region: ImpE; pfam07024 234267000702 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 234267000703 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 234267000704 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 234267000705 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 234267000706 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 234267000707 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 234267000708 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 234267000709 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 234267000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267000711 Walker A motif; other site 234267000712 ATP binding site [chemical binding]; other site 234267000713 Walker B motif; other site 234267000714 arginine finger; other site 234267000715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267000716 Walker A motif; other site 234267000717 ATP binding site [chemical binding]; other site 234267000718 Walker B motif; other site 234267000719 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234267000720 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 234267000721 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 234267000722 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 234267000723 PAAR motif; Region: PAAR_motif; pfam05488 234267000724 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267000725 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 234267000726 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 234267000727 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 234267000728 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 234267000729 tetramer interface [polypeptide binding]; other site 234267000730 active site 234267000731 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 234267000732 heterodimer interface [polypeptide binding]; other site 234267000733 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 234267000734 active site 234267000735 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 234267000736 heterodimer interface [polypeptide binding]; other site 234267000737 multimer interface [polypeptide binding]; other site 234267000738 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 234267000739 active site 234267000740 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 234267000741 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 234267000742 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 234267000743 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234267000744 Bacterial transcriptional regulator; Region: IclR; pfam01614 234267000745 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 234267000746 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234267000747 dimer interface [polypeptide binding]; other site 234267000748 active site 234267000749 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 234267000750 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234267000751 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 234267000752 substrate binding site [chemical binding]; other site 234267000753 THF binding site; other site 234267000754 zinc-binding site [ion binding]; other site 234267000755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267000756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267000757 putative substrate translocation pore; other site 234267000758 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 234267000759 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234267000760 substrate binding site [chemical binding]; other site 234267000761 oxyanion hole (OAH) forming residues; other site 234267000762 trimer interface [polypeptide binding]; other site 234267000763 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 234267000764 CoA binding domain; Region: CoA_binding_2; pfam13380 234267000765 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 234267000766 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 234267000767 Predicted peptidase [General function prediction only]; Region: COG4099 234267000768 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 234267000769 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 234267000770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267000771 Tannase and feruloyl esterase; Region: Tannase; pfam07519 234267000772 Tannase and feruloyl esterase; Region: Tannase; pfam07519 234267000773 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 234267000774 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 234267000775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267000776 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 234267000777 DinB superfamily; Region: DinB_2; pfam12867 234267000778 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 234267000779 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 234267000780 Alginate lyase; Region: Alginate_lyase; pfam05426 234267000781 active site 234267000782 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234267000783 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234267000784 metal binding site [ion binding]; metal-binding site 234267000785 active site 234267000786 I-site; other site 234267000787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267000788 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 234267000789 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 234267000790 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 234267000791 active site 234267000792 dimer interface [polypeptide binding]; other site 234267000793 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 234267000794 Ligand Binding Site [chemical binding]; other site 234267000795 Molecular Tunnel; other site 234267000796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267000797 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267000798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267000799 S-adenosylmethionine binding site [chemical binding]; other site 234267000800 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 234267000801 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 234267000802 Ligand binding site; other site 234267000803 Putative Catalytic site; other site 234267000804 DXD motif; other site 234267000805 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 234267000806 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234267000807 inhibitor-cofactor binding pocket; inhibition site 234267000808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267000809 catalytic residue [active] 234267000810 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 234267000811 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267000812 Ligand binding site; other site 234267000813 Putative Catalytic site; other site 234267000814 DXD motif; other site 234267000815 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 234267000816 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267000817 NAD binding site [chemical binding]; other site 234267000818 homotetramer interface [polypeptide binding]; other site 234267000819 homodimer interface [polypeptide binding]; other site 234267000820 active site 234267000821 substrate binding site [chemical binding]; other site 234267000822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267000823 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 234267000824 NAD binding site [chemical binding]; other site 234267000825 homotetramer interface [polypeptide binding]; other site 234267000826 homodimer interface [polypeptide binding]; other site 234267000827 active site 234267000828 substrate binding site [chemical binding]; other site 234267000829 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234267000830 Low molecular weight phosphatase family; Region: LMWPc; cl00105 234267000831 active site 234267000832 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 234267000833 predicted active site [active] 234267000834 catalytic triad [active] 234267000835 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 234267000836 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 234267000837 active site 234267000838 multimer interface [polypeptide binding]; other site 234267000839 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234267000840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267000841 DNA-binding site [nucleotide binding]; DNA binding site 234267000842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267000843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267000844 homodimer interface [polypeptide binding]; other site 234267000845 catalytic residue [active] 234267000846 TPR repeat; Region: TPR_11; pfam13414 234267000847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267000848 binding surface 234267000849 TPR motif; other site 234267000850 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234267000851 homotrimer interaction site [polypeptide binding]; other site 234267000852 putative active site [active] 234267000853 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234267000854 homotrimer interaction site [polypeptide binding]; other site 234267000855 putative active site [active] 234267000856 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267000857 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267000858 metal ion-dependent adhesion site (MIDAS); other site 234267000859 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 234267000860 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 234267000861 Catalytic site [active] 234267000862 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 234267000863 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234267000864 minor groove reading motif; other site 234267000865 helix-hairpin-helix signature motif; other site 234267000866 substrate binding pocket [chemical binding]; other site 234267000867 active site 234267000868 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 234267000869 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 234267000870 DNA binding and oxoG recognition site [nucleotide binding] 234267000871 Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; Region: Reeler; cd08544 234267000872 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267000873 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 234267000874 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 234267000875 generic binding surface II; other site 234267000876 generic binding surface I; other site 234267000877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267000878 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 234267000879 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 234267000880 active site 234267000881 Zn binding site [ion binding]; other site 234267000882 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 234267000883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267000884 FeS/SAM binding site; other site 234267000885 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 234267000886 Ligand Binding Site [chemical binding]; other site 234267000887 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267000888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267000889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267000890 glycogen synthase; Provisional; Region: glgA; PRK00654 234267000891 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 234267000892 ADP-binding pocket [chemical binding]; other site 234267000893 homodimer interface [polypeptide binding]; other site 234267000894 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 234267000895 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267000896 catalytic residues [active] 234267000897 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267000898 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 234267000899 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 234267000900 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267000901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267000902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267000903 DNA binding residues [nucleotide binding] 234267000904 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 234267000905 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 234267000906 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 234267000907 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 234267000908 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 234267000909 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 234267000910 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 234267000911 active site 234267000912 DNA binding site [nucleotide binding] 234267000913 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 234267000914 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267000915 Rhomboid family; Region: Rhomboid; pfam01694 234267000916 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 234267000917 intersubunit interface [polypeptide binding]; other site 234267000918 active site 234267000919 Zn2+ binding site [ion binding]; other site 234267000920 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 234267000921 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 234267000922 Hexamer interface [polypeptide binding]; other site 234267000923 Hexagonal pore residue; other site 234267000924 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 234267000925 Hexamer/Pentamer interface [polypeptide binding]; other site 234267000926 central pore; other site 234267000927 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 234267000928 Hexamer/Pentamer interface [polypeptide binding]; other site 234267000929 central pore; other site 234267000930 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 234267000931 Hexamer/Pentamer interface [polypeptide binding]; other site 234267000932 central pore; other site 234267000933 FliW protein; Region: FliW; pfam02623 234267000934 Global regulator protein family; Region: CsrA; cl00670 234267000935 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 234267000936 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 234267000937 FliW protein; Region: FliW; pfam02623 234267000938 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 234267000939 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 234267000940 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 234267000941 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 234267000942 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 234267000943 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 234267000944 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 234267000945 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267000946 ligand binding site [chemical binding]; other site 234267000947 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 234267000948 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 234267000949 Flagellar protein (FlbD); Region: FlbD; pfam06289 234267000950 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 234267000951 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 234267000952 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 234267000953 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 234267000954 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267000955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234267000956 DNA binding residues [nucleotide binding] 234267000957 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 234267000958 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 234267000959 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 234267000960 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 234267000961 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 234267000962 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 234267000963 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 234267000964 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 234267000965 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 234267000966 FliG C-terminal domain; Region: FliG_C; pfam01706 234267000967 Flagellar assembly protein FliH; Region: FliH; pfam02108 234267000968 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 234267000969 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234267000970 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 234267000971 Walker A motif/ATP binding site; other site 234267000972 Walker B motif; other site 234267000973 putative heme peroxidase; Provisional; Region: PRK12276 234267000974 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 234267000975 Glucose inhibited division protein A; Region: GIDA; pfam01134 234267000976 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267000977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267000978 active site 234267000979 DNA binding site [nucleotide binding] 234267000980 Int/Topo IB signature motif; other site 234267000981 multidrug efflux protein; Reviewed; Region: PRK01766 234267000982 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 234267000983 cation binding site [ion binding]; other site 234267000984 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 234267000985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267000986 putative homodimer interface [polypeptide binding]; other site 234267000987 hypothetical protein; Provisional; Region: PRK07208 234267000988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267000989 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267000990 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267000991 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 234267000992 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234267000993 tetramer interface [polypeptide binding]; other site 234267000994 TPP-binding site [chemical binding]; other site 234267000995 heterodimer interface [polypeptide binding]; other site 234267000996 phosphorylation loop region [posttranslational modification] 234267000997 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234267000998 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234267000999 alpha subunit interface [polypeptide binding]; other site 234267001000 TPP binding site [chemical binding]; other site 234267001001 heterodimer interface [polypeptide binding]; other site 234267001002 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267001003 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 234267001004 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267001005 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 234267001006 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 234267001007 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267001008 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267001009 guanine deaminase; Provisional; Region: PRK09228 234267001010 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267001011 active site 234267001012 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 234267001013 urate oxidase; Region: urate_oxi; TIGR03383 234267001014 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 234267001015 active site 234267001016 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 234267001017 active site 234267001018 homotetramer interface [polypeptide binding]; other site 234267001019 allantoate amidohydrolase; Reviewed; Region: PRK09290 234267001020 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 234267001021 active site 234267001022 metal binding site [ion binding]; metal-binding site 234267001023 dimer interface [polypeptide binding]; other site 234267001024 allantoinase; Provisional; Region: PRK06189 234267001025 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 234267001026 active site 234267001027 hypothetical protein; Provisional; Region: PRK11171 234267001028 Cupin domain; Region: Cupin_2; pfam07883 234267001029 allantoate amidohydrolase; Reviewed; Region: PRK09290 234267001030 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 234267001031 active site 234267001032 metal binding site [ion binding]; metal-binding site 234267001033 dimer interface [polypeptide binding]; other site 234267001034 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267001035 M28 Zn-Peptidases; Region: M28_like_4; cd08015 234267001036 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267001037 metal binding site [ion binding]; metal-binding site 234267001038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267001039 aspartate aminotransferase; Provisional; Region: PRK05764 234267001040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267001041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267001042 homodimer interface [polypeptide binding]; other site 234267001043 catalytic residue [active] 234267001044 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267001045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267001046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267001047 DNA binding residues [nucleotide binding] 234267001048 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 234267001049 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 234267001050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267001051 putative substrate translocation pore; other site 234267001052 POT family; Region: PTR2; cl17359 234267001053 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 234267001054 putative active site [active] 234267001055 homotetrameric interface [polypeptide binding]; other site 234267001056 metal binding site [ion binding]; metal-binding site 234267001057 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 234267001058 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234267001059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267001060 Coenzyme A binding pocket [chemical binding]; other site 234267001061 Peptidase family M49; Region: Peptidase_M49; pfam03571 234267001062 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 234267001063 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 234267001064 putative active site [active] 234267001065 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 234267001066 putative catalytic site [active] 234267001067 putative metal binding site [ion binding]; other site 234267001068 putative phosphate binding site [ion binding]; other site 234267001069 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 234267001070 putative active site [active] 234267001071 catalytic site [active] 234267001072 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 234267001073 PLD-like domain; Region: PLDc_2; pfam13091 234267001074 putative active site [active] 234267001075 catalytic site [active] 234267001076 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 234267001077 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 234267001078 Hexamer interface [polypeptide binding]; other site 234267001079 Putative hexagonal pore residue; other site 234267001080 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 234267001081 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 234267001082 putative catalytic cysteine [active] 234267001083 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 234267001084 DHH family; Region: DHH; pfam01368 234267001085 DHHA1 domain; Region: DHHA1; pfam02272 234267001086 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 234267001087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267001088 active site 234267001089 catalytic tetrad [active] 234267001090 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 234267001091 Domain of unknown function (DUF362); Region: DUF362; pfam04015 234267001092 Uncharacterized conserved protein [Function unknown]; Region: COG2006 234267001093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 234267001094 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 234267001095 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 234267001096 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267001097 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 234267001098 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 234267001099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267001100 dimerization interface [polypeptide binding]; other site 234267001101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267001102 dimer interface [polypeptide binding]; other site 234267001103 phosphorylation site [posttranslational modification] 234267001104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267001105 ATP binding site [chemical binding]; other site 234267001106 Mg2+ binding site [ion binding]; other site 234267001107 G-X-G motif; other site 234267001108 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 234267001109 active site 234267001110 Zn binding site [ion binding]; other site 234267001111 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267001112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001113 active site 234267001114 phosphorylation site [posttranslational modification] 234267001115 intermolecular recognition site; other site 234267001116 dimerization interface [polypeptide binding]; other site 234267001117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001118 Walker A motif; other site 234267001119 ATP binding site [chemical binding]; other site 234267001120 Walker B motif; other site 234267001121 arginine finger; other site 234267001122 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267001123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267001124 Helix-turn-helix domain; Region: HTH_18; pfam12833 234267001125 Cupin domain; Region: Cupin_2; pfam07883 234267001126 CoA binding domain; Region: CoA_binding_2; pfam13380 234267001127 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 234267001128 lipoyl-biotinyl attachment site [posttranslational modification]; other site 234267001129 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 234267001130 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 234267001131 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267001132 molybdopterin cofactor binding site; other site 234267001133 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 234267001134 heme-binding residues [chemical binding]; other site 234267001135 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 234267001136 lipoyl-biotinyl attachment site [posttranslational modification]; other site 234267001137 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 234267001138 putative homodimer interface [polypeptide binding]; other site 234267001139 putative active site pocket [active] 234267001140 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 234267001141 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234267001142 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267001143 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267001144 catalytic residue [active] 234267001145 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 234267001146 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234267001147 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234267001148 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 234267001149 dimer interface [polypeptide binding]; other site 234267001150 decamer (pentamer of dimers) interface [polypeptide binding]; other site 234267001151 catalytic triad [active] 234267001152 peroxidatic and resolving cysteines [active] 234267001153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267001154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267001155 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234267001156 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 234267001157 trimer interface [polypeptide binding]; other site 234267001158 active site 234267001159 Thymidylate synthase complementing protein; Region: Thy1; cl03630 234267001160 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267001161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267001162 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267001163 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 234267001164 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 234267001165 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 234267001166 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 234267001167 Substrate binding site; other site 234267001168 Mg++ binding site; other site 234267001169 metal-binding site 234267001170 Mg++ binding site; other site 234267001171 metal-binding site 234267001172 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 234267001173 active site 234267001174 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 234267001175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267001176 active site 234267001177 motif I; other site 234267001178 motif II; other site 234267001179 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267001180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267001181 PAS domain; Region: PAS_9; pfam13426 234267001182 putative active site [active] 234267001183 heme pocket [chemical binding]; other site 234267001184 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 234267001185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001186 Walker A motif; other site 234267001187 ATP binding site [chemical binding]; other site 234267001188 Walker B motif; other site 234267001189 arginine finger; other site 234267001190 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267001191 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 234267001192 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267001193 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 234267001194 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 234267001195 Zn binding sites [ion binding]; other site 234267001196 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267001197 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 234267001198 heme-binding residues [chemical binding]; other site 234267001199 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 234267001200 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 234267001201 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267001202 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267001203 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267001204 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234267001205 FAD binding domain; Region: FAD_binding_4; pfam01565 234267001206 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 234267001207 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267001208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001209 active site 234267001210 phosphorylation site [posttranslational modification] 234267001211 intermolecular recognition site; other site 234267001212 dimerization interface [polypeptide binding]; other site 234267001213 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234267001214 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234267001215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267001216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267001217 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267001218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267001219 ligand binding site [chemical binding]; other site 234267001220 flexible hinge region; other site 234267001221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267001222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267001223 ATP binding site [chemical binding]; other site 234267001224 Mg2+ binding site [ion binding]; other site 234267001225 G-X-G motif; other site 234267001226 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 234267001227 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 234267001228 active site 234267001229 DNA binding site [nucleotide binding] 234267001230 Int/Topo IB signature motif; other site 234267001231 catalytic residues [active] 234267001232 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 234267001233 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 234267001234 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 234267001235 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 234267001236 glutaminase; Reviewed; Region: PRK12356 234267001237 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 234267001238 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267001239 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 234267001240 DinB family; Region: DinB; cl17821 234267001241 DinB superfamily; Region: DinB_2; pfam12867 234267001242 Protein of unknown function DUF72; Region: DUF72; pfam01904 234267001243 Membrane protein of unknown function; Region: DUF360; pfam04020 234267001244 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 234267001245 FAD binding domain; Region: FAD_binding_4; pfam01565 234267001246 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 234267001247 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 234267001248 Cysteine-rich domain; Region: CCG; pfam02754 234267001249 Cysteine-rich domain; Region: CCG; pfam02754 234267001250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267001251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267001252 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 234267001253 Walker A/P-loop; other site 234267001254 ATP binding site [chemical binding]; other site 234267001255 Q-loop/lid; other site 234267001256 ABC transporter signature motif; other site 234267001257 Walker B; other site 234267001258 D-loop; other site 234267001259 H-loop/switch region; other site 234267001260 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 234267001261 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 234267001262 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 234267001263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267001265 active site 234267001266 phosphorylation site [posttranslational modification] 234267001267 intermolecular recognition site; other site 234267001268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267001269 dimer interface [polypeptide binding]; other site 234267001270 phosphorylation site [posttranslational modification] 234267001271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267001272 ATP binding site [chemical binding]; other site 234267001273 Mg2+ binding site [ion binding]; other site 234267001274 G-X-G motif; other site 234267001275 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267001276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001277 active site 234267001278 phosphorylation site [posttranslational modification] 234267001279 intermolecular recognition site; other site 234267001280 dimerization interface [polypeptide binding]; other site 234267001281 4Fe-4S binding domain; Region: Fer4_5; pfam12801 234267001282 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 234267001283 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 234267001284 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 234267001285 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267001286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267001287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267001288 DNA binding residues [nucleotide binding] 234267001289 OsmC-like protein; Region: OsmC; pfam02566 234267001290 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 234267001291 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 234267001292 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 234267001293 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 234267001294 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234267001295 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 234267001296 beta subunit interaction interface [polypeptide binding]; other site 234267001297 Walker A motif; other site 234267001298 ATP binding site [chemical binding]; other site 234267001299 Walker B motif; other site 234267001300 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 234267001301 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 234267001302 core domain interface [polypeptide binding]; other site 234267001303 delta subunit interface [polypeptide binding]; other site 234267001304 epsilon subunit interface [polypeptide binding]; other site 234267001305 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234267001306 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 234267001307 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 234267001308 alpha subunit interaction interface [polypeptide binding]; other site 234267001309 Walker A motif; other site 234267001310 ATP binding site [chemical binding]; other site 234267001311 Walker B motif; other site 234267001312 inhibitor binding site; inhibition site 234267001313 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 234267001314 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 234267001315 gamma subunit interface [polypeptide binding]; other site 234267001316 epsilon subunit interface [polypeptide binding]; other site 234267001317 LBP interface [polypeptide binding]; other site 234267001318 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267001319 Ligand binding site; other site 234267001320 Putative Catalytic site; other site 234267001321 DXD motif; other site 234267001322 Predicted membrane protein [Function unknown]; Region: COG2246 234267001323 GtrA-like protein; Region: GtrA; pfam04138 234267001324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267001325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234267001326 DNA binding site [nucleotide binding] 234267001327 domain linker motif; other site 234267001328 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267001329 ligand binding site [chemical binding]; other site 234267001330 dimerization interface [polypeptide binding]; other site 234267001331 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267001332 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267001333 Smr domain; Region: Smr; pfam01713 234267001334 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 234267001335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267001336 Coenzyme A binding pocket [chemical binding]; other site 234267001337 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 234267001338 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267001339 NAD(P) binding site [chemical binding]; other site 234267001340 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 234267001341 oxidative damage protection protein; Provisional; Region: PRK05408 234267001342 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 234267001343 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 234267001344 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267001345 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 234267001346 tetramer interface [polypeptide binding]; other site 234267001347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267001348 catalytic residue [active] 234267001349 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 234267001350 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 234267001351 tetramer interface [polypeptide binding]; other site 234267001352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267001353 catalytic residue [active] 234267001354 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 234267001355 lipoyl attachment site [posttranslational modification]; other site 234267001356 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 234267001357 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 234267001358 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 234267001359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267001360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267001361 DNA binding site [nucleotide binding] 234267001362 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 234267001363 active site 234267001364 dimer interface [polypeptide binding]; other site 234267001365 catalytic nucleophile [active] 234267001366 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 234267001367 heme-binding residues [chemical binding]; other site 234267001368 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267001369 molybdopterin cofactor binding site; other site 234267001370 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 234267001371 4Fe-4S binding domain; Region: Fer4; cl02805 234267001372 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 234267001373 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 234267001374 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 234267001375 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 234267001376 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267001377 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267001378 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 234267001379 Cu(I) binding site [ion binding]; other site 234267001380 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 234267001381 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 234267001382 Cytochrome c; Region: Cytochrom_C; pfam00034 234267001383 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234267001384 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 234267001385 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 234267001386 Subunit I/III interface [polypeptide binding]; other site 234267001387 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 234267001388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001389 TPR motif; other site 234267001390 binding surface 234267001391 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267001392 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267001393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267001394 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267001395 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267001396 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267001397 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 234267001398 Clp amino terminal domain; Region: Clp_N; pfam02861 234267001399 Clp amino terminal domain; Region: Clp_N; pfam02861 234267001400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001401 Walker A motif; other site 234267001402 ATP binding site [chemical binding]; other site 234267001403 Walker B motif; other site 234267001404 arginine finger; other site 234267001405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001406 Walker A motif; other site 234267001407 ATP binding site [chemical binding]; other site 234267001408 Walker B motif; other site 234267001409 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234267001410 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 234267001411 oligomeric interface; other site 234267001412 putative active site [active] 234267001413 homodimer interface [polypeptide binding]; other site 234267001414 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 234267001415 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 234267001416 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 234267001417 Walker A/P-loop; other site 234267001418 ATP binding site [chemical binding]; other site 234267001419 Q-loop/lid; other site 234267001420 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 234267001421 ABC transporter signature motif; other site 234267001422 Walker B; other site 234267001423 D-loop; other site 234267001424 H-loop/switch region; other site 234267001425 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 234267001426 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 234267001427 TolR protein; Region: tolR; TIGR02801 234267001428 TonB C terminal; Region: TonB_2; pfam13103 234267001429 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267001430 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001431 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001432 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001433 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267001434 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267001435 ligand binding site [chemical binding]; other site 234267001436 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 234267001437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001438 TPR motif; other site 234267001439 binding surface 234267001440 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 234267001441 intersubunit interface [polypeptide binding]; other site 234267001442 active site 234267001443 catalytic residue [active] 234267001444 Cupin domain; Region: Cupin_2; cl17218 234267001445 NHL repeat; Region: NHL; pfam01436 234267001446 NHL repeat; Region: NHL; pfam01436 234267001447 NHL repeat; Region: NHL; pfam01436 234267001448 NHL repeat; Region: NHL; pfam01436 234267001449 NHL repeat; Region: NHL; pfam01436 234267001450 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267001451 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234267001452 Thioredoxin; Region: Thioredoxin_4; pfam13462 234267001453 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234267001454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001455 S-adenosylmethionine binding site [chemical binding]; other site 234267001456 homoserine dehydrogenase; Provisional; Region: PRK06349 234267001457 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 234267001458 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 234267001459 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 234267001460 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 234267001461 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 234267001462 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 234267001463 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 234267001464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 234267001465 ATP binding site [chemical binding]; other site 234267001466 Mg2+ binding site [ion binding]; other site 234267001467 G-X-G motif; other site 234267001468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 234267001469 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 234267001470 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 234267001471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267001472 ATP binding site [chemical binding]; other site 234267001473 Mg2+ binding site [ion binding]; other site 234267001474 G-X-G motif; other site 234267001475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234267001476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267001477 dimer interface [polypeptide binding]; other site 234267001478 phosphorylation site [posttranslational modification] 234267001479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267001480 ATP binding site [chemical binding]; other site 234267001481 Mg2+ binding site [ion binding]; other site 234267001482 G-X-G motif; other site 234267001483 Response regulator receiver domain; Region: Response_reg; pfam00072 234267001484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001485 active site 234267001486 phosphorylation site [posttranslational modification] 234267001487 intermolecular recognition site; other site 234267001488 dimerization interface [polypeptide binding]; other site 234267001489 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267001490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001491 active site 234267001492 phosphorylation site [posttranslational modification] 234267001493 intermolecular recognition site; other site 234267001494 dimerization interface [polypeptide binding]; other site 234267001495 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 234267001496 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 234267001497 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 234267001498 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234267001499 active site 234267001500 DNA binding site [nucleotide binding] 234267001501 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267001502 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267001503 Trp docking motif [polypeptide binding]; other site 234267001504 active site 234267001505 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267001506 Cytochrome c; Region: Cytochrom_C; pfam00034 234267001507 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 234267001508 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234267001509 classical (c) SDRs; Region: SDR_c; cd05233 234267001510 NAD(P) binding site [chemical binding]; other site 234267001511 active site 234267001512 Domain of unknown function (DUF3601); Region: DUF3601; pfam12208 234267001513 threonine synthase; Validated; Region: PRK08197 234267001514 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 234267001515 homodimer interface [polypeptide binding]; other site 234267001516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267001517 catalytic residue [active] 234267001518 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 234267001519 O-Antigen ligase; Region: Wzy_C; pfam04932 234267001520 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 234267001521 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 234267001522 putative ribose interaction site [chemical binding]; other site 234267001523 putative ADP binding site [chemical binding]; other site 234267001524 putative translaldolase; Provisional; Region: PRK12376 234267001525 catalytic residue [active] 234267001526 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 234267001527 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 234267001528 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234267001529 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 234267001530 Beta-propeller repeat; Region: SBBP; pfam06739 234267001531 Beta-propeller repeat; Region: SBBP; pfam06739 234267001532 Beta-propeller repeat; Region: SBBP; pfam06739 234267001533 Beta-propeller repeat; Region: SBBP; pfam06739 234267001534 Beta-propeller repeat; Region: SBBP; pfam06739 234267001535 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234267001536 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267001537 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 234267001538 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 234267001539 Walker A/P-loop; other site 234267001540 ATP binding site [chemical binding]; other site 234267001541 Q-loop/lid; other site 234267001542 ABC transporter signature motif; other site 234267001543 Walker B; other site 234267001544 D-loop; other site 234267001545 H-loop/switch region; other site 234267001546 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 234267001547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001548 S-adenosylmethionine binding site [chemical binding]; other site 234267001549 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 234267001550 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 234267001551 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 234267001552 putative glycosyl transferase; Provisional; Region: PRK10073 234267001553 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 234267001554 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 234267001555 bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412 234267001556 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 234267001557 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001558 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267001559 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001560 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267001561 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001562 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 234267001563 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267001564 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 234267001565 protein binding site [polypeptide binding]; other site 234267001566 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 234267001567 Domain interface; other site 234267001568 Peptide binding site; other site 234267001569 Active site tetrad [active] 234267001570 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267001571 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 234267001572 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 234267001573 dimer interface [polypeptide binding]; other site 234267001574 ADP-ribose binding site [chemical binding]; other site 234267001575 active site 234267001576 nudix motif; other site 234267001577 metal binding site [ion binding]; metal-binding site 234267001578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267001579 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 234267001580 NAD binding site [chemical binding]; other site 234267001581 homodimer interface [polypeptide binding]; other site 234267001582 active site 234267001583 putative substrate binding site [chemical binding]; other site 234267001584 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 234267001585 Ligand binding site; other site 234267001586 Ligand binding site; other site 234267001587 Ligand binding site; other site 234267001588 Putative Catalytic site; other site 234267001589 DXD motif; other site 234267001590 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267001591 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267001592 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 234267001593 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 234267001594 peptidase domain interface [polypeptide binding]; other site 234267001595 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 234267001596 active site 234267001597 catalytic triad [active] 234267001598 calcium binding site [ion binding]; other site 234267001599 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 234267001600 putative active site [active] 234267001601 YdjC motif; other site 234267001602 Mg binding site [ion binding]; other site 234267001603 putative homodimer interface [polypeptide binding]; other site 234267001604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234267001605 mce related protein; Region: MCE; pfam02470 234267001606 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 234267001607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267001608 Walker A/P-loop; other site 234267001609 ATP binding site [chemical binding]; other site 234267001610 Q-loop/lid; other site 234267001611 ABC transporter signature motif; other site 234267001612 Walker B; other site 234267001613 D-loop; other site 234267001614 H-loop/switch region; other site 234267001615 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234267001616 Permease; Region: Permease; pfam02405 234267001617 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 234267001618 putative active site pocket [active] 234267001619 cleavage site 234267001620 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267001621 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267001622 active site 234267001623 ATP binding site [chemical binding]; other site 234267001624 substrate binding site [chemical binding]; other site 234267001625 activation loop (A-loop); other site 234267001626 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 234267001627 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 234267001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267001629 putative substrate translocation pore; other site 234267001630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234267001631 putative acyl-acceptor binding pocket; other site 234267001632 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 234267001633 acyl-activating enzyme (AAE) consensus motif; other site 234267001634 putative AMP binding site [chemical binding]; other site 234267001635 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267001636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001637 Walker A motif; other site 234267001638 ATP binding site [chemical binding]; other site 234267001639 Walker B motif; other site 234267001640 arginine finger; other site 234267001641 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234267001642 homotrimer interaction site [polypeptide binding]; other site 234267001643 putative active site [active] 234267001644 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234267001645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267001646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267001647 Family description; Region: VCBS; pfam13517 234267001648 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001649 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001650 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001651 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267001652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267001653 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267001654 putative active site [active] 234267001655 heme pocket [chemical binding]; other site 234267001656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267001657 dimer interface [polypeptide binding]; other site 234267001658 phosphorylation site [posttranslational modification] 234267001659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267001660 ATP binding site [chemical binding]; other site 234267001661 Mg2+ binding site [ion binding]; other site 234267001662 G-X-G motif; other site 234267001663 Response regulator receiver domain; Region: Response_reg; pfam00072 234267001664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267001665 active site 234267001666 phosphorylation site [posttranslational modification] 234267001667 intermolecular recognition site; other site 234267001668 dimerization interface [polypeptide binding]; other site 234267001669 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 234267001670 putative acyl-acceptor binding pocket; other site 234267001671 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 234267001672 active site 234267001673 metal binding site [ion binding]; metal-binding site 234267001674 homotetramer interface [polypeptide binding]; other site 234267001675 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 234267001676 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 234267001677 Ligand Binding Site [chemical binding]; other site 234267001678 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 234267001679 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 234267001680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267001681 catalytic residue [active] 234267001682 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 234267001683 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 234267001684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267001685 Walker A/P-loop; other site 234267001686 ATP binding site [chemical binding]; other site 234267001687 Q-loop/lid; other site 234267001688 ABC transporter signature motif; other site 234267001689 Walker B; other site 234267001690 D-loop; other site 234267001691 H-loop/switch region; other site 234267001692 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234267001693 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267001694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267001695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267001696 Penicillin amidase; Region: Penicil_amidase; pfam01804 234267001697 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267001698 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 234267001699 active site 234267001700 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267001701 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 234267001702 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 234267001703 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267001704 bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412 234267001705 bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412 234267001706 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267001707 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234267001708 active site 234267001709 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 234267001710 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234267001711 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 234267001712 metal-binding site 234267001713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267001714 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 234267001715 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 234267001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001717 S-adenosylmethionine binding site [chemical binding]; other site 234267001718 Methyltransferase domain; Region: Methyltransf_24; pfam13578 234267001719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234267001720 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 234267001721 metal-binding site 234267001722 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 234267001723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267001724 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 234267001725 NAD synthetase; Provisional; Region: PRK13981 234267001726 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 234267001727 multimer interface [polypeptide binding]; other site 234267001728 active site 234267001729 catalytic triad [active] 234267001730 protein interface 1 [polypeptide binding]; other site 234267001731 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 234267001732 homodimer interface [polypeptide binding]; other site 234267001733 NAD binding pocket [chemical binding]; other site 234267001734 ATP binding pocket [chemical binding]; other site 234267001735 Mg binding site [ion binding]; other site 234267001736 active-site loop [active] 234267001737 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 234267001738 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267001739 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234267001740 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 234267001741 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267001742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001743 S-adenosylmethionine binding site [chemical binding]; other site 234267001744 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 234267001745 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 234267001746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234267001747 Radical SAM superfamily; Region: Radical_SAM; pfam04055 234267001748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 234267001749 FeS/SAM binding site; other site 234267001750 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 234267001751 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 234267001752 Family description; Region: VCBS; pfam13517 234267001753 Family description; Region: VCBS; pfam13517 234267001754 FG-GAP repeat; Region: FG-GAP; pfam01839 234267001755 Family description; Region: VCBS; pfam13517 234267001756 Family description; Region: VCBS; pfam13517 234267001757 Family description; Region: VCBS; pfam13517 234267001758 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 234267001759 Family description; Region: VCBS; pfam13517 234267001760 Family description; Region: VCBS; pfam13517 234267001761 Family description; Region: VCBS; pfam13517 234267001762 Family description; Region: VCBS; pfam13517 234267001763 Family description; Region: VCBS; pfam13517 234267001764 FG-GAP repeat; Region: FG-GAP; pfam01839 234267001765 Family description; Region: VCBS; pfam13517 234267001766 Family description; Region: VCBS; pfam13517 234267001767 Family description; Region: VCBS; pfam13517 234267001768 Family description; Region: VCBS; pfam13517 234267001769 Family description; Region: VCBS; pfam13517 234267001770 Family description; Region: VCBS; pfam13517 234267001771 Family description; Region: VCBS; pfam13517 234267001772 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267001773 active site 234267001774 Int/Topo IB signature motif; other site 234267001775 DNA binding site [nucleotide binding] 234267001776 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 234267001777 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 234267001778 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 234267001779 Int/Topo IB signature motif; other site 234267001780 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267001781 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 234267001782 Int/Topo IB signature motif; other site 234267001783 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 234267001784 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267001785 active site 234267001786 Int/Topo IB signature motif; other site 234267001787 DNA binding site [nucleotide binding] 234267001788 Transposase; Region: HTH_Tnp_1; pfam01527 234267001789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267001790 putative transposase OrfB; Reviewed; Region: PHA02517 234267001791 HTH-like domain; Region: HTH_21; pfam13276 234267001792 Integrase core domain; Region: rve; pfam00665 234267001793 Integrase core domain; Region: rve_3; pfam13683 234267001794 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 234267001795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 234267001796 Transposase; Region: DDE_Tnp_ISL3; pfam01610 234267001797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001798 Walker A motif; other site 234267001799 ATP binding site [chemical binding]; other site 234267001800 Walker B motif; other site 234267001801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234267001802 ParB-like nuclease domain; Region: ParB; smart00470 234267001803 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 234267001804 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267001805 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267001806 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267001807 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 234267001808 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 234267001809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 234267001810 TPP-binding site [chemical binding]; other site 234267001811 dimer interface [polypeptide binding]; other site 234267001812 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 234267001813 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234267001814 PYR/PP interface [polypeptide binding]; other site 234267001815 dimer interface [polypeptide binding]; other site 234267001816 TPP binding site [chemical binding]; other site 234267001817 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267001818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267001819 NAD(P) binding site [chemical binding]; other site 234267001820 active site 234267001821 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 234267001822 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 234267001823 Ligand binding site; other site 234267001824 Putative Catalytic site; other site 234267001825 DXD motif; other site 234267001826 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267001827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001828 S-adenosylmethionine binding site [chemical binding]; other site 234267001829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001830 S-adenosylmethionine binding site [chemical binding]; other site 234267001831 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267001832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267001833 S-adenosylmethionine binding site [chemical binding]; other site 234267001834 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 234267001835 KTSC domain; Region: KTSC; pfam13619 234267001836 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 234267001837 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 234267001838 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 234267001839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267001840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267001841 putative substrate translocation pore; other site 234267001842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267001843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234267001844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267001845 DNA-binding site [nucleotide binding]; DNA binding site 234267001846 FCD domain; Region: FCD; pfam07729 234267001847 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267001848 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267001849 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267001850 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267001851 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267001852 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267001853 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267001854 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267001855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267001856 D-galactonate transporter; Region: 2A0114; TIGR00893 234267001857 putative substrate translocation pore; other site 234267001858 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 234267001859 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267001860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267001861 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 234267001862 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 234267001863 tetrameric interface [polypeptide binding]; other site 234267001864 NAD binding site [chemical binding]; other site 234267001865 catalytic residues [active] 234267001866 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 234267001867 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234267001868 nucleotide binding site [chemical binding]; other site 234267001869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267001870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267001871 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234267001872 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 234267001873 active site 234267001874 FMN binding site [chemical binding]; other site 234267001875 substrate binding site [chemical binding]; other site 234267001876 homotetramer interface [polypeptide binding]; other site 234267001877 catalytic residue [active] 234267001878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267001879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267001880 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267001881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001882 binding surface 234267001883 TPR motif; other site 234267001884 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267001885 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267001886 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267001887 TPR repeat; Region: TPR_11; pfam13414 234267001888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001889 binding surface 234267001890 TPR motif; other site 234267001891 TPR repeat; Region: TPR_11; pfam13414 234267001892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001893 TPR motif; other site 234267001894 binding surface 234267001895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001896 binding surface 234267001897 TPR motif; other site 234267001898 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 234267001899 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 234267001900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267001901 non-specific DNA binding site [nucleotide binding]; other site 234267001902 salt bridge; other site 234267001903 sequence-specific DNA binding site [nucleotide binding]; other site 234267001904 primosome assembly protein PriA; Validated; Region: PRK05580 234267001905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267001906 ATP binding site [chemical binding]; other site 234267001907 putative Mg++ binding site [ion binding]; other site 234267001908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267001909 ATP-binding site [chemical binding]; other site 234267001910 GTP-binding protein YchF; Reviewed; Region: PRK09601 234267001911 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 234267001912 G1 box; other site 234267001913 GTP/Mg2+ binding site [chemical binding]; other site 234267001914 Switch I region; other site 234267001915 G3 box; other site 234267001916 Switch II region; other site 234267001917 G4 box; other site 234267001918 G5 box; other site 234267001919 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 234267001920 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267001921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267001922 Walker A motif; other site 234267001923 ATP binding site [chemical binding]; other site 234267001924 Walker B motif; other site 234267001925 arginine finger; other site 234267001926 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234267001927 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267001928 thioredoxin 2; Provisional; Region: PRK10996 234267001929 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 234267001930 catalytic residues [active] 234267001931 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 234267001932 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 234267001933 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 234267001934 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267001935 active site 234267001936 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267001937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267001938 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267001939 DNA binding residues [nucleotide binding] 234267001940 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 234267001941 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267001942 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267001943 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267001944 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267001945 FtsX-like permease family; Region: FtsX; pfam02687 234267001946 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267001947 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267001948 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267001949 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 234267001950 BON domain; Region: BON; pfam04972 234267001951 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 234267001952 alpha-galactosidase; Region: PLN02808; cl17638 234267001953 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 234267001954 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 234267001955 putative hexamer interface [polypeptide binding]; other site 234267001956 putative hexagonal pore; other site 234267001957 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 234267001958 putative hexamer interface [polypeptide binding]; other site 234267001959 putative hexagonal pore; other site 234267001960 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 234267001961 SLBB domain; Region: SLBB; pfam10531 234267001962 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 234267001963 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267001964 inhibitor site; inhibition site 234267001965 active site 234267001966 dimer interface [polypeptide binding]; other site 234267001967 catalytic residue [active] 234267001968 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267001969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267001970 active site 234267001971 Right handed beta helix region; Region: Beta_helix; pfam13229 234267001972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267001973 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267001974 TPR motif; other site 234267001975 binding surface 234267001976 Sulfatase; Region: Sulfatase; cl17466 234267001977 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267001978 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267001979 Winged helix-turn helix; Region: HTH_29; pfam13551 234267001980 DNA-binding interface [nucleotide binding]; DNA binding site 234267001981 Homeodomain-like domain; Region: HTH_32; pfam13565 234267001982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267001983 Integrase core domain; Region: rve; pfam00665 234267001984 Integrase core domain; Region: rve_3; pfam13683 234267001985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267001986 Family description; Region: VCBS; pfam13517 234267001987 Family description; Region: VCBS; pfam13517 234267001988 Family description; Region: VCBS; pfam13517 234267001989 Family description; Region: VCBS; pfam13517 234267001990 Family description; Region: VCBS; pfam13517 234267001991 Family description; Region: VCBS; pfam13517 234267001992 Family description; Region: VCBS; pfam13517 234267001993 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267001994 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267001995 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267001996 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 234267001997 Predicted membrane protein [Function unknown]; Region: COG4818 234267001998 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 234267001999 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234267002000 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 234267002001 nucleotide binding site [chemical binding]; other site 234267002002 N-acetyl-L-glutamate binding site [chemical binding]; other site 234267002003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267002004 Coenzyme A binding pocket [chemical binding]; other site 234267002005 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 234267002006 putative MPT binding site; other site 234267002007 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 234267002008 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 234267002009 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267002010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267002011 Walker A/P-loop; other site 234267002012 ATP binding site [chemical binding]; other site 234267002013 Q-loop/lid; other site 234267002014 ABC transporter signature motif; other site 234267002015 Walker B; other site 234267002016 D-loop; other site 234267002017 H-loop/switch region; other site 234267002018 Outer membrane efflux protein; Region: OEP; pfam02321 234267002019 Outer membrane efflux protein; Region: OEP; pfam02321 234267002020 Outer membrane efflux protein; Region: OEP; pfam02321 234267002021 Outer membrane efflux protein; Region: OEP; pfam02321 234267002022 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 234267002023 GrpE; Region: GrpE; pfam01025 234267002024 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 234267002025 dimer interface [polypeptide binding]; other site 234267002026 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 234267002027 chaperone protein DnaJ; Provisional; Region: PRK10767 234267002028 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234267002029 HSP70 interaction site [polypeptide binding]; other site 234267002030 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 234267002031 substrate binding site [polypeptide binding]; other site 234267002032 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 234267002033 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 234267002034 dimer interface [polypeptide binding]; other site 234267002035 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267002036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267002037 active site 234267002038 phosphorylation site [posttranslational modification] 234267002039 intermolecular recognition site; other site 234267002040 dimerization interface [polypeptide binding]; other site 234267002041 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 234267002042 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 234267002043 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 234267002044 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 234267002045 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 234267002046 NHL repeat; Region: NHL; pfam01436 234267002047 NHL repeat; Region: NHL; pfam01436 234267002048 NHL repeat; Region: NHL; pfam01436 234267002049 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267002050 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234267002051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267002052 ATP binding site [chemical binding]; other site 234267002053 putative Mg++ binding site [ion binding]; other site 234267002054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267002055 nucleotide binding region [chemical binding]; other site 234267002056 ATP-binding site [chemical binding]; other site 234267002057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267002058 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234267002059 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 234267002060 dimer interface [polypeptide binding]; other site 234267002061 active site 234267002062 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 234267002063 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234267002064 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 234267002065 NodB motif; other site 234267002066 active site 234267002067 catalytic site [active] 234267002068 metal binding site [ion binding]; metal-binding site 234267002069 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 234267002070 Family of unknown function (DUF490); Region: DUF490; pfam04357 234267002071 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 234267002072 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267002073 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 234267002074 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267002075 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267002076 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267002077 Surface antigen; Region: Bac_surface_Ag; pfam01103 234267002078 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 234267002079 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 234267002080 ATP binding site [chemical binding]; other site 234267002081 substrate interface [chemical binding]; other site 234267002082 short chain dehydrogenase; Validated; Region: PRK06182 234267002083 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 234267002084 NADP binding site [chemical binding]; other site 234267002085 active site 234267002086 steroid binding site; other site 234267002087 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267002088 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002089 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002090 FtsX-like permease family; Region: FtsX; pfam02687 234267002091 FOG: CBS domain [General function prediction only]; Region: COG0517 234267002092 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 234267002093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267002094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267002095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267002096 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 234267002097 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 234267002098 active site 234267002099 putative substrate binding pocket [chemical binding]; other site 234267002100 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267002101 hypothetical protein; Validated; Region: PRK07411 234267002102 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 234267002103 ATP binding site [chemical binding]; other site 234267002104 substrate interface [chemical binding]; other site 234267002105 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234267002106 active site residue [active] 234267002107 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 234267002108 MoaE interaction surface [polypeptide binding]; other site 234267002109 MoeB interaction surface [polypeptide binding]; other site 234267002110 thiocarboxylated glycine; other site 234267002111 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 234267002112 MPN+ (JAMM) motif; other site 234267002113 Zinc-binding site [ion binding]; other site 234267002114 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 234267002115 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 234267002116 dimer interface [polypeptide binding]; other site 234267002117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267002118 catalytic residue [active] 234267002119 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267002120 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267002121 PAS domain S-box; Region: sensory_box; TIGR00229 234267002122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267002123 putative active site [active] 234267002124 heme pocket [chemical binding]; other site 234267002125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267002126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267002127 dimer interface [polypeptide binding]; other site 234267002128 phosphorylation site [posttranslational modification] 234267002129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267002130 ATP binding site [chemical binding]; other site 234267002131 Mg2+ binding site [ion binding]; other site 234267002132 G-X-G motif; other site 234267002133 Response regulator receiver domain; Region: Response_reg; pfam00072 234267002134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267002135 active site 234267002136 phosphorylation site [posttranslational modification] 234267002137 intermolecular recognition site; other site 234267002138 dimerization interface [polypeptide binding]; other site 234267002139 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 234267002140 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234267002141 active site 234267002142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002143 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267002144 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002145 FtsX-like permease family; Region: FtsX; pfam02687 234267002146 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267002147 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267002148 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 234267002149 ATP synthase I chain; Region: ATP_synt_I; pfam03899 234267002150 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 234267002151 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 234267002152 PilZ domain; Region: PilZ; pfam07238 234267002153 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 234267002154 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267002155 ATP binding site [chemical binding]; other site 234267002156 putative Mg++ binding site [ion binding]; other site 234267002157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267002158 nucleotide binding region [chemical binding]; other site 234267002159 ATP-binding site [chemical binding]; other site 234267002160 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 234267002161 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 234267002162 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 234267002163 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 234267002164 Peptidase family M1; Region: Peptidase_M1; pfam01433 234267002165 Zn binding site [ion binding]; other site 234267002166 TPR repeat; Region: TPR_11; pfam13414 234267002167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002168 binding surface 234267002169 TPR motif; other site 234267002170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267002171 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 234267002172 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267002173 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 234267002174 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234267002175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267002176 NAD(P) binding site [chemical binding]; other site 234267002177 active site 234267002178 shikimate kinase; Reviewed; Region: aroK; PRK00131 234267002179 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 234267002180 ADP binding site [chemical binding]; other site 234267002181 magnesium binding site [ion binding]; other site 234267002182 putative shikimate binding site; other site 234267002183 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 234267002184 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 234267002185 MOFRL family; Region: MOFRL; pfam05161 234267002186 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002187 binding surface 234267002188 TPR motif; other site 234267002189 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 234267002190 EamA-like transporter family; Region: EamA; pfam00892 234267002191 EamA-like transporter family; Region: EamA; pfam00892 234267002192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267002193 putative substrate translocation pore; other site 234267002194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267002195 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267002196 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 234267002197 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 234267002198 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 234267002199 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 234267002200 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 234267002201 seryl-tRNA synthetase; Provisional; Region: PRK05431 234267002202 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 234267002203 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267002204 B-box zinc finger; Region: zf-B_box; pfam00643 234267002205 Zn2+ binding site [ion binding]; other site 234267002206 TM2 domain; Region: TM2; pfam05154 234267002207 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 234267002208 Putative zinc-finger; Region: zf-HC2; pfam13490 234267002209 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267002210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267002211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267002212 DNA binding residues [nucleotide binding] 234267002213 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 234267002214 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 234267002215 ATP cone domain; Region: ATP-cone; pfam03477 234267002216 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 234267002217 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 234267002218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267002219 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234267002220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267002221 DNA binding residues [nucleotide binding] 234267002222 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 234267002223 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234267002224 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267002225 Catalytic site [active] 234267002226 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 234267002227 hypothetical protein; Provisional; Region: PRK09133 234267002228 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234267002229 putative metal binding site [ion binding]; other site 234267002230 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 234267002231 N- and C-terminal domain interface [polypeptide binding]; other site 234267002232 D-xylulose kinase; Region: XylB; TIGR01312 234267002233 active site 234267002234 MgATP binding site [chemical binding]; other site 234267002235 catalytic site [active] 234267002236 metal binding site [ion binding]; metal-binding site 234267002237 xylulose binding site [chemical binding]; other site 234267002238 homodimer interface [polypeptide binding]; other site 234267002239 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267002240 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 234267002241 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 234267002242 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 234267002243 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 234267002244 active site 234267002245 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234267002246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234267002247 nucleotide binding site [chemical binding]; other site 234267002248 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267002249 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267002250 transaminase; Validated; Region: PRK07324 234267002251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267002252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267002253 homodimer interface [polypeptide binding]; other site 234267002254 catalytic residue [active] 234267002255 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 234267002256 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 234267002257 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 234267002258 EamA-like transporter family; Region: EamA; pfam00892 234267002259 EamA-like transporter family; Region: EamA; pfam00892 234267002260 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 234267002261 Putative zinc ribbon domain; Region: DUF164; pfam02591 234267002262 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 234267002263 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 234267002264 putative substrate binding site [chemical binding]; other site 234267002265 putative ATP binding site [chemical binding]; other site 234267002266 Winged helix-turn helix; Region: HTH_29; pfam13551 234267002267 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267002268 DNA-binding interface [nucleotide binding]; DNA binding site 234267002269 Homeodomain-like domain; Region: HTH_32; pfam13565 234267002270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267002271 Integrase core domain; Region: rve; pfam00665 234267002272 Integrase core domain; Region: rve_3; pfam13683 234267002273 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 234267002274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267002275 S-adenosylmethionine binding site [chemical binding]; other site 234267002276 thiamine monophosphate kinase; Provisional; Region: PRK05731 234267002277 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 234267002278 ATP binding site [chemical binding]; other site 234267002279 dimerization interface [polypeptide binding]; other site 234267002280 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 234267002281 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267002282 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 234267002283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234267002284 DNA-binding site [nucleotide binding]; DNA binding site 234267002285 RNA-binding motif; other site 234267002286 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 234267002287 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 234267002288 putative ligand binding site [chemical binding]; other site 234267002289 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 234267002290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234267002291 ABC-ATPase subunit interface; other site 234267002292 dimer interface [polypeptide binding]; other site 234267002293 putative PBP binding regions; other site 234267002294 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 234267002295 Putative esterase; Region: Esterase; pfam00756 234267002296 Predicted acyl esterases [General function prediction only]; Region: COG2936 234267002297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267002298 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 234267002299 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 234267002300 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 234267002301 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 234267002302 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 234267002303 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 234267002304 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 234267002305 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 234267002306 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 234267002307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267002308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267002309 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267002310 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 234267002311 molybdopterin cofactor binding site; other site 234267002312 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234267002313 Cupin; Region: Cupin_1; smart00835 234267002314 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 234267002315 Cupin; Region: Cupin_1; smart00835 234267002316 Predicted membrane protein [Function unknown]; Region: COG2855 234267002317 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267002318 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267002319 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267002320 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267002321 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267002322 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267002323 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267002324 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267002325 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267002326 LabA_like proteins; Region: LabA_like; cd06167 234267002327 putative metal binding site [ion binding]; other site 234267002328 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267002329 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267002330 active site 234267002331 catalytic tetrad [active] 234267002332 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267002333 hypothetical protein; Provisional; Region: PRK08609 234267002334 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 234267002335 active site 234267002336 primer binding site [nucleotide binding]; other site 234267002337 NTP binding site [chemical binding]; other site 234267002338 metal binding triad [ion binding]; metal-binding site 234267002339 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 234267002340 active site 234267002341 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 234267002342 dimer interface [polypeptide binding]; other site 234267002343 ADP-ribose binding site [chemical binding]; other site 234267002344 active site 234267002345 nudix motif; other site 234267002346 metal binding site [ion binding]; metal-binding site 234267002347 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 234267002348 active site 234267002349 DNA polymerase IV; Validated; Region: PRK02406 234267002350 DNA binding site [nucleotide binding] 234267002351 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267002352 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 234267002353 protein binding site [polypeptide binding]; other site 234267002354 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 234267002355 Domain interface; other site 234267002356 Peptide binding site; other site 234267002357 Active site tetrad [active] 234267002358 Protein of unknown function (DUF620); Region: DUF620; pfam04788 234267002359 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267002360 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267002361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267002362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267002363 Walker A/P-loop; other site 234267002364 ATP binding site [chemical binding]; other site 234267002365 Q-loop/lid; other site 234267002366 ABC transporter signature motif; other site 234267002367 Walker B; other site 234267002368 D-loop; other site 234267002369 H-loop/switch region; other site 234267002370 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267002371 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267002372 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267002373 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267002374 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267002375 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267002376 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267002377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267002378 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234267002379 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234267002380 Walker A/P-loop; other site 234267002381 ATP binding site [chemical binding]; other site 234267002382 Q-loop/lid; other site 234267002383 ABC transporter signature motif; other site 234267002384 Walker B; other site 234267002385 D-loop; other site 234267002386 H-loop/switch region; other site 234267002387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 234267002388 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234267002389 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 234267002390 allophanate hydrolase; Provisional; Region: PRK08186 234267002391 Amidase; Region: Amidase; cl11426 234267002392 urea carboxylase; Region: urea_carbox; TIGR02712 234267002393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234267002394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234267002395 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 234267002396 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 234267002397 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 234267002398 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267002399 carboxyltransferase (CT) interaction site; other site 234267002400 biotinylation site [posttranslational modification]; other site 234267002401 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 234267002402 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 234267002403 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 234267002404 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 234267002405 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267002406 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267002407 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267002408 active site 234267002409 ATP binding site [chemical binding]; other site 234267002410 substrate binding site [chemical binding]; other site 234267002411 activation loop (A-loop); other site 234267002412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002413 binding surface 234267002414 TPR motif; other site 234267002415 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267002416 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267002417 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267002418 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267002419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267002420 active site 234267002421 ATP binding site [chemical binding]; other site 234267002422 substrate binding site [chemical binding]; other site 234267002423 activation loop (A-loop); other site 234267002424 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267002425 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267002426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002427 TPR motif; other site 234267002428 binding surface 234267002429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002430 TPR motif; other site 234267002431 binding surface 234267002432 Ion channel; Region: Ion_trans_2; pfam07885 234267002433 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 234267002434 intracellular protease, PfpI family; Region: PfpI; TIGR01382 234267002435 proposed catalytic triad [active] 234267002436 conserved cys residue [active] 234267002437 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 234267002438 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 234267002439 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267002440 B12 binding site [chemical binding]; other site 234267002441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267002442 FeS/SAM binding site; other site 234267002443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267002444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002445 binding surface 234267002446 TPR motif; other site 234267002447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267002448 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267002449 Sulfatase; Region: Sulfatase; pfam00884 234267002450 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267002451 M28 Zn-Peptidases; Region: M28_like_4; cd08015 234267002452 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267002453 metal binding site [ion binding]; metal-binding site 234267002454 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 234267002455 putative hydrophobic ligand binding site [chemical binding]; other site 234267002456 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267002457 Amidase; Region: Amidase; pfam01425 234267002458 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267002459 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267002460 active site 234267002461 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 234267002462 Putative glucoamylase; Region: Glycoamylase; pfam10091 234267002463 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 234267002464 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 234267002465 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 234267002466 Protein of unknown function, DUF608; Region: DUF608; pfam04685 234267002467 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 234267002468 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 234267002469 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 234267002470 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 234267002471 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 234267002472 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 234267002473 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 234267002474 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 234267002475 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 234267002476 PIN domain; Region: PIN_3; pfam13470 234267002477 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 234267002478 Penicillinase repressor; Region: Pencillinase_R; cl17580 234267002479 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267002480 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234267002481 Ligand Binding Site [chemical binding]; other site 234267002482 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 234267002483 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 234267002484 ribosome recycling factor; Reviewed; Region: frr; PRK00083 234267002485 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 234267002486 hinge region; other site 234267002487 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 234267002488 putative nucleotide binding site [chemical binding]; other site 234267002489 uridine monophosphate binding site [chemical binding]; other site 234267002490 homohexameric interface [polypeptide binding]; other site 234267002491 elongation factor Ts; Reviewed; Region: tsf; PRK12332 234267002492 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 234267002493 Elongation factor TS; Region: EF_TS; pfam00889 234267002494 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 234267002495 rRNA interaction site [nucleotide binding]; other site 234267002496 S8 interaction site; other site 234267002497 putative laminin-1 binding site; other site 234267002498 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 234267002499 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 234267002500 23S rRNA interface [nucleotide binding]; other site 234267002501 L3 interface [polypeptide binding]; other site 234267002502 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 234267002503 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234267002504 Isochorismatase family; Region: Isochorismatase; pfam00857 234267002505 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 234267002506 catalytic triad [active] 234267002507 conserved cis-peptide bond; other site 234267002508 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267002509 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267002510 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 234267002511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267002512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267002513 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234267002514 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 234267002515 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 234267002516 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234267002517 E3 interaction surface; other site 234267002518 lipoyl attachment site [posttranslational modification]; other site 234267002519 e3 binding domain; Region: E3_binding; pfam02817 234267002520 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234267002521 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 234267002522 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 234267002523 tyramine oxidase; Provisional; Region: tynA; PRK11504 234267002524 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 234267002525 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 234267002526 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 234267002527 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234267002528 DNA-binding site [nucleotide binding]; DNA binding site 234267002529 RNA-binding motif; other site 234267002530 Protein of unknown function (DUF3738); Region: DUF3738; pfam12543 234267002531 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267002532 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267002533 Active site serine [active] 234267002534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 234267002535 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 234267002536 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 234267002537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234267002538 nucleotide binding site [chemical binding]; other site 234267002539 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 234267002540 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 234267002541 Protein of unknown function, DUF485; Region: DUF485; pfam04341 234267002542 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 234267002543 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 234267002544 Na binding site [ion binding]; other site 234267002545 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 234267002546 amidohydrolase; Region: amidohydrolases; TIGR01891 234267002547 putative metal binding site [ion binding]; other site 234267002548 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267002549 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267002550 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267002551 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267002552 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267002553 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267002554 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267002555 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267002556 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267002557 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267002558 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267002559 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267002560 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 234267002561 Melibiase; Region: Melibiase; pfam02065 234267002562 RHS Repeat; Region: RHS_repeat; pfam05593 234267002563 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 234267002564 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 234267002565 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234267002566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267002567 non-specific DNA binding site [nucleotide binding]; other site 234267002568 salt bridge; other site 234267002569 sequence-specific DNA binding site [nucleotide binding]; other site 234267002570 putative transposase OrfB; Reviewed; Region: PHA02517 234267002571 HTH-like domain; Region: HTH_21; pfam13276 234267002572 Integrase core domain; Region: rve; pfam00665 234267002573 Integrase core domain; Region: rve_3; pfam13683 234267002574 Transposase; Region: HTH_Tnp_1; pfam01527 234267002575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267002576 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267002577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234267002578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002579 TPR motif; other site 234267002580 binding surface 234267002581 CHAT domain; Region: CHAT; pfam12770 234267002582 Peptidase family S64; Region: Peptidase_S64; pfam08192 234267002583 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267002584 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267002585 active site 234267002586 ATP binding site [chemical binding]; other site 234267002587 substrate binding site [chemical binding]; other site 234267002588 activation loop (A-loop); other site 234267002589 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267002590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267002591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267002592 binding surface 234267002593 TPR motif; other site 234267002594 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 234267002595 active site 234267002596 metal binding site [ion binding]; metal-binding site 234267002597 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267002598 phosphodiesterase YaeI; Provisional; Region: PRK11340 234267002599 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 234267002600 putative active site [active] 234267002601 putative metal binding site [ion binding]; other site 234267002602 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 234267002603 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 234267002604 RuvA N terminal domain; Region: RuvA_N; pfam01330 234267002605 Y-family of DNA polymerases; Region: PolY; cl12025 234267002606 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 234267002607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267002608 Walker A motif; other site 234267002609 ATP binding site [chemical binding]; other site 234267002610 Walker B motif; other site 234267002611 arginine finger; other site 234267002612 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 234267002613 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 234267002614 catalytic center binding site [active] 234267002615 ATP binding site [chemical binding]; other site 234267002616 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234267002617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267002618 ATP binding site [chemical binding]; other site 234267002619 putative Mg++ binding site [ion binding]; other site 234267002620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267002621 nucleotide binding region [chemical binding]; other site 234267002622 ATP-binding site [chemical binding]; other site 234267002623 HRDC domain; Region: HRDC; pfam00570 234267002624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267002625 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 234267002626 NAD(P) binding site [chemical binding]; other site 234267002627 active site 234267002628 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 234267002629 putative hydrophobic ligand binding site [chemical binding]; other site 234267002630 Peptidase family C69; Region: Peptidase_C69; cl17793 234267002631 YtxH-like protein; Region: YtxH; pfam12732 234267002632 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 234267002633 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 234267002634 dimer interface [polypeptide binding]; other site 234267002635 [2Fe-2S] cluster binding site [ion binding]; other site 234267002636 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 234267002637 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234267002638 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 234267002639 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234267002640 NAD(P) binding site [chemical binding]; other site 234267002641 catalytic residues [active] 234267002642 Helix-turn-helix domain; Region: HTH_37; pfam13744 234267002643 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 234267002644 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 234267002645 active site 234267002646 NTP binding site [chemical binding]; other site 234267002647 metal binding triad [ion binding]; metal-binding site 234267002648 Repair protein; Region: Repair_PSII; pfam04536 234267002649 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267002650 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267002651 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267002652 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267002653 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 234267002654 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 234267002655 nucleotide binding site [chemical binding]; other site 234267002656 putative NEF/HSP70 interaction site [polypeptide binding]; other site 234267002657 SBD interface [polypeptide binding]; other site 234267002658 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 234267002659 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267002660 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 234267002661 nucleotide binding site [chemical binding]; other site 234267002662 putative NEF/HSP70 interaction site [polypeptide binding]; other site 234267002663 SBD interface [polypeptide binding]; other site 234267002664 DNA-K related protein; Region: DUF3731; pfam12531 234267002665 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 234267002666 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267002667 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002668 FtsX-like permease family; Region: FtsX; pfam02687 234267002669 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002670 FtsX-like permease family; Region: FtsX; pfam02687 234267002671 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267002672 active site 234267002673 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267002674 anthranilate synthase; Provisional; Region: PRK13566 234267002675 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 234267002676 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 234267002677 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 234267002678 glutamine binding [chemical binding]; other site 234267002679 catalytic triad [active] 234267002680 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267002681 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267002682 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234267002683 classical (c) SDRs; Region: SDR_c; cd05233 234267002684 NAD(P) binding site [chemical binding]; other site 234267002685 active site 234267002686 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 234267002687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267002688 motif II; other site 234267002689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267002690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267002691 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 234267002692 Walker A/P-loop; other site 234267002693 ATP binding site [chemical binding]; other site 234267002694 Q-loop/lid; other site 234267002695 ABC transporter signature motif; other site 234267002696 Walker B; other site 234267002697 D-loop; other site 234267002698 H-loop/switch region; other site 234267002699 tellurite resistance protein TehB; Provisional; Region: PRK11207 234267002700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267002701 S-adenosylmethionine binding site [chemical binding]; other site 234267002702 malonyl-CoA synthase; Validated; Region: PRK07514 234267002703 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 234267002704 acyl-activating enzyme (AAE) consensus motif; other site 234267002705 active site 234267002706 AMP binding site [chemical binding]; other site 234267002707 CoA binding site [chemical binding]; other site 234267002708 benzoate transport; Region: 2A0115; TIGR00895 234267002709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267002710 putative substrate translocation pore; other site 234267002711 AAA domain; Region: AAA_33; pfam13671 234267002712 AAA domain; Region: AAA_17; pfam13207 234267002713 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 234267002714 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267002715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 234267002716 Nudix hydrolase homolog; Region: PLN02791 234267002717 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 234267002718 hexamer (dimer of trimers) interface [polypeptide binding]; other site 234267002719 substrate binding site [chemical binding]; other site 234267002720 trimer interface [polypeptide binding]; other site 234267002721 Mn binding site [ion binding]; other site 234267002722 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 234267002723 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267002724 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 234267002725 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 234267002726 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 234267002727 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 234267002728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267002729 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234267002730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267002731 DNA binding residues [nucleotide binding] 234267002732 DNA primase; Validated; Region: dnaG; PRK05667 234267002733 CHC2 zinc finger; Region: zf-CHC2; pfam01807 234267002734 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 234267002735 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 234267002736 active site 234267002737 metal binding site [ion binding]; metal-binding site 234267002738 interdomain interaction site; other site 234267002739 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 234267002740 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 234267002741 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 234267002742 IHF - DNA interface [nucleotide binding]; other site 234267002743 IHF dimer interface [polypeptide binding]; other site 234267002744 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234267002745 Walker A motif; other site 234267002746 ATP binding site [chemical binding]; other site 234267002747 Walker B motif; other site 234267002748 recombinase A; Provisional; Region: recA; PRK09354 234267002749 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 234267002750 hexamer interface [polypeptide binding]; other site 234267002751 Walker A motif; other site 234267002752 ATP binding site [chemical binding]; other site 234267002753 Walker B motif; other site 234267002754 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 234267002755 peptidase PmbA; Provisional; Region: PRK11040 234267002756 protease TldD; Provisional; Region: tldD; PRK10735 234267002757 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 234267002758 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 234267002759 NADP-binding site; other site 234267002760 homotetramer interface [polypeptide binding]; other site 234267002761 substrate binding site [chemical binding]; other site 234267002762 homodimer interface [polypeptide binding]; other site 234267002763 active site 234267002764 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267002765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267002766 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267002767 DNA binding residues [nucleotide binding] 234267002768 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 234267002769 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267002770 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 234267002771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267002772 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 234267002773 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 234267002774 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 234267002775 ferrochelatase; Reviewed; Region: hemH; PRK00035 234267002776 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 234267002777 C-terminal domain interface [polypeptide binding]; other site 234267002778 active site 234267002779 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 234267002780 active site 234267002781 N-terminal domain interface [polypeptide binding]; other site 234267002782 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267002783 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267002784 ligand binding site [chemical binding]; other site 234267002785 flexible hinge region; other site 234267002786 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234267002787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267002788 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267002789 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 234267002790 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267002791 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267002792 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 234267002793 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002794 FtsX-like permease family; Region: FtsX; pfam02687 234267002795 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 234267002796 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 234267002797 dimer interface [polypeptide binding]; other site 234267002798 putative anticodon binding site; other site 234267002799 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 234267002800 motif 1; other site 234267002801 active site 234267002802 motif 2; other site 234267002803 motif 3; other site 234267002804 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 234267002805 Ligand binding site; other site 234267002806 Ligand binding site; other site 234267002807 Ligand binding site; other site 234267002808 Putative Catalytic site; other site 234267002809 DXD motif; other site 234267002810 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267002811 Methyltransferase domain; Region: Methyltransf_12; pfam08242 234267002812 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 234267002813 GTP-binding protein Der; Reviewed; Region: PRK00093 234267002814 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 234267002815 G1 box; other site 234267002816 GTP/Mg2+ binding site [chemical binding]; other site 234267002817 Switch I region; other site 234267002818 G2 box; other site 234267002819 Switch II region; other site 234267002820 G3 box; other site 234267002821 G4 box; other site 234267002822 G5 box; other site 234267002823 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 234267002824 G1 box; other site 234267002825 GTP/Mg2+ binding site [chemical binding]; other site 234267002826 Switch I region; other site 234267002827 G2 box; other site 234267002828 G3 box; other site 234267002829 Switch II region; other site 234267002830 G4 box; other site 234267002831 G5 box; other site 234267002832 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 234267002833 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 234267002834 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 234267002835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267002836 ATP binding site [chemical binding]; other site 234267002837 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 234267002838 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 234267002839 active site 234267002840 Ferredoxin [Energy production and conversion]; Region: COG1146 234267002841 4Fe-4S binding domain; Region: Fer4; cl02805 234267002842 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 234267002843 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 234267002844 active site 234267002845 tetramer interface; other site 234267002846 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267002847 Trp docking motif [polypeptide binding]; other site 234267002848 putative active site [active] 234267002849 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267002850 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267002851 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267002852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002853 FtsX-like permease family; Region: FtsX; pfam02687 234267002854 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267002855 FtsX-like permease family; Region: FtsX; pfam02687 234267002856 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234267002857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 234267002858 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 234267002859 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 234267002860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 234267002861 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 234267002862 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 234267002863 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 234267002864 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 234267002865 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267002866 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267002867 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 234267002868 FAD binding domain; Region: FAD_binding_4; pfam01565 234267002869 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 234267002870 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 234267002871 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 234267002872 N-terminal plug; other site 234267002873 ligand-binding site [chemical binding]; other site 234267002874 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 234267002875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267002876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267002877 dimerization interface [polypeptide binding]; other site 234267002878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267002879 dimer interface [polypeptide binding]; other site 234267002880 phosphorylation site [posttranslational modification] 234267002881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267002882 ATP binding site [chemical binding]; other site 234267002883 Mg2+ binding site [ion binding]; other site 234267002884 G-X-G motif; other site 234267002885 Response regulator receiver domain; Region: Response_reg; pfam00072 234267002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267002887 active site 234267002888 phosphorylation site [posttranslational modification] 234267002889 intermolecular recognition site; other site 234267002890 dimerization interface [polypeptide binding]; other site 234267002891 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 234267002892 SmpB-tmRNA interface; other site 234267002893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267002894 TPR repeat; Region: TPR_11; pfam13414 234267002895 binding surface 234267002896 TPR motif; other site 234267002897 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 234267002898 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 234267002899 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 234267002900 dockerin binding interface; other site 234267002901 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 234267002902 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 234267002903 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 234267002904 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 234267002905 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267002906 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 234267002907 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 234267002908 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 234267002909 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 234267002910 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234267002911 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267002912 inhibitor site; inhibition site 234267002913 active site 234267002914 dimer interface [polypeptide binding]; other site 234267002915 catalytic residue [active] 234267002916 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 234267002917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267002918 CHASE3 domain; Region: CHASE3; cl05000 234267002919 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 234267002920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 234267002921 dimer interface [polypeptide binding]; other site 234267002922 putative CheW interface [polypeptide binding]; other site 234267002923 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234267002924 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 234267002925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234267002926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267002927 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234267002928 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 234267002929 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 234267002930 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 234267002931 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267002932 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 234267002933 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 234267002934 Protein of unknown function (DUF721); Region: DUF721; pfam05258 234267002935 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234267002936 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267002937 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267002938 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267002939 active site 234267002940 catalytic tetrad [active] 234267002941 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 234267002942 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 234267002943 active site 234267002944 substrate-binding site [chemical binding]; other site 234267002945 metal-binding site [ion binding] 234267002946 ATP binding site [chemical binding]; other site 234267002947 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234267002948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267002949 putative substrate translocation pore; other site 234267002950 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 234267002951 Maf-like protein; Region: Maf; pfam02545 234267002952 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 234267002953 active site 234267002954 dimer interface [polypeptide binding]; other site 234267002955 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267002956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267002957 metal ion-dependent adhesion site (MIDAS); other site 234267002958 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 234267002959 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 234267002960 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 234267002961 putative active site [active] 234267002962 Zn binding site [ion binding]; other site 234267002963 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 234267002964 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 234267002965 trmE is a tRNA modification GTPase; Region: trmE; cd04164 234267002966 G1 box; other site 234267002967 GTP/Mg2+ binding site [chemical binding]; other site 234267002968 Switch I region; other site 234267002969 G2 box; other site 234267002970 Switch II region; other site 234267002971 G3 box; other site 234267002972 G4 box; other site 234267002973 G5 box; other site 234267002974 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 234267002975 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 234267002976 RxxxH motif; other site 234267002977 membrane protein insertase; Provisional; Region: PRK01318 234267002978 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 234267002979 Haemolytic domain; Region: Haemolytic; pfam01809 234267002980 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 234267002981 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 234267002982 Putative zinc-finger; Region: zf-HC2; pfam13490 234267002983 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267002984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267002985 active site 234267002986 metal binding site [ion binding]; metal-binding site 234267002987 Cytochrome c; Region: Cytochrom_C; cl11414 234267002988 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 234267002989 active site 234267002990 catalytic triad [active] 234267002991 Pectic acid lyase; Region: Pec_lyase; pfam09492 234267002992 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 234267002993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267002994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267002995 active site 234267002996 phosphorylation site [posttranslational modification] 234267002997 intermolecular recognition site; other site 234267002998 dimerization interface [polypeptide binding]; other site 234267002999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267003000 DNA binding site [nucleotide binding] 234267003001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267003002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267003003 dimer interface [polypeptide binding]; other site 234267003004 phosphorylation site [posttranslational modification] 234267003005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267003006 ATP binding site [chemical binding]; other site 234267003007 Mg2+ binding site [ion binding]; other site 234267003008 G-X-G motif; other site 234267003009 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 234267003010 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234267003011 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234267003012 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 234267003013 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 234267003014 ligand binding site; other site 234267003015 oligomer interface; other site 234267003016 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 234267003017 dimer interface [polypeptide binding]; other site 234267003018 N-terminal domain interface [polypeptide binding]; other site 234267003019 sulfate 1 binding site; other site 234267003020 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 234267003021 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 234267003022 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 234267003023 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234267003024 Na binding site [ion binding]; other site 234267003025 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267003026 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267003027 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267003028 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267003029 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267003030 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 234267003031 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267003032 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 234267003033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267003034 PAS fold; Region: PAS_3; pfam08447 234267003035 putative active site [active] 234267003036 heme pocket [chemical binding]; other site 234267003037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267003038 ATP binding site [chemical binding]; other site 234267003039 Mg2+ binding site [ion binding]; other site 234267003040 G-X-G motif; other site 234267003041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003042 Response regulator receiver domain; Region: Response_reg; pfam00072 234267003043 active site 234267003044 phosphorylation site [posttranslational modification] 234267003045 intermolecular recognition site; other site 234267003046 dimerization interface [polypeptide binding]; other site 234267003047 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 234267003048 metal binding site 2 [ion binding]; metal-binding site 234267003049 putative DNA binding helix; other site 234267003050 metal binding site 1 [ion binding]; metal-binding site 234267003051 dimer interface [polypeptide binding]; other site 234267003052 structural Zn2+ binding site [ion binding]; other site 234267003053 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 234267003054 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 234267003055 dimer interface [polypeptide binding]; other site 234267003056 active site 234267003057 heme binding site [chemical binding]; other site 234267003058 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 234267003059 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 234267003060 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 234267003061 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 234267003062 substrate binding pocket [chemical binding]; other site 234267003063 chain length determination region; other site 234267003064 substrate-Mg2+ binding site; other site 234267003065 catalytic residues [active] 234267003066 aspartate-rich region 1; other site 234267003067 active site lid residues [active] 234267003068 aspartate-rich region 2; other site 234267003069 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 234267003070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267003071 RNA binding surface [nucleotide binding]; other site 234267003072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267003073 S-adenosylmethionine binding site [chemical binding]; other site 234267003074 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 234267003075 ATP-NAD kinase; Region: NAD_kinase; pfam01513 234267003076 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 234267003077 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 234267003078 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 234267003079 AhpC/TSA family; Region: AhpC-TSA; pfam00578 234267003080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267003081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267003082 Yip1 domain; Region: Yip1; pfam04893 234267003083 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267003084 IPT/TIG domain; Region: TIG; pfam01833 234267003085 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267003086 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267003087 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 234267003088 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 234267003089 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267003090 Walker A/P-loop; other site 234267003091 ATP binding site [chemical binding]; other site 234267003092 Q-loop/lid; other site 234267003093 ABC transporter signature motif; other site 234267003094 Walker B; other site 234267003095 D-loop; other site 234267003096 H-loop/switch region; other site 234267003097 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267003098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267003099 DNA binding residues [nucleotide binding] 234267003100 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267003101 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267003102 active site 234267003103 ATP binding site [chemical binding]; other site 234267003104 substrate binding site [chemical binding]; other site 234267003105 activation loop (A-loop); other site 234267003106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267003107 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267003108 Winged helix-turn helix; Region: HTH_29; pfam13551 234267003109 DNA-binding interface [nucleotide binding]; DNA binding site 234267003110 Homeodomain-like domain; Region: HTH_32; pfam13565 234267003111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267003112 Integrase core domain; Region: rve; pfam00665 234267003113 Integrase core domain; Region: rve_3; pfam13683 234267003114 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003115 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267003116 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 234267003117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003118 active site 234267003119 phosphorylation site [posttranslational modification] 234267003120 intermolecular recognition site; other site 234267003121 dimerization interface [polypeptide binding]; other site 234267003122 LytTr DNA-binding domain; Region: LytTR; smart00850 234267003123 Histidine kinase; Region: His_kinase; pfam06580 234267003124 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234267003125 ATP binding site [chemical binding]; other site 234267003126 Mg2+ binding site [ion binding]; other site 234267003127 G-X-G motif; other site 234267003128 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267003129 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267003130 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267003131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003132 active site 234267003133 phosphorylation site [posttranslational modification] 234267003134 intermolecular recognition site; other site 234267003135 AAA domain; Region: AAA_31; pfam13614 234267003136 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 234267003137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267003138 YtxH-like protein; Region: YtxH; pfam12732 234267003139 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267003140 Asp-box motif; other site 234267003141 NHL repeat; Region: NHL; pfam01436 234267003142 NHL repeat; Region: NHL; pfam01436 234267003143 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267003144 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267003145 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267003146 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267003147 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267003148 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267003149 Trp docking motif [polypeptide binding]; other site 234267003150 PQQ-like domain; Region: PQQ_2; pfam13360 234267003151 putative active site [active] 234267003152 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267003153 AAA domain; Region: AAA_21; pfam13304 234267003154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267003155 ABC transporter signature motif; other site 234267003156 Walker B; other site 234267003157 D-loop; other site 234267003158 H-loop/switch region; other site 234267003159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267003160 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267003161 active site 234267003162 metal binding site [ion binding]; metal-binding site 234267003163 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 234267003164 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 234267003165 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267003166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267003167 active site 234267003168 ATP binding site [chemical binding]; other site 234267003169 substrate binding site [chemical binding]; other site 234267003170 activation loop (A-loop); other site 234267003171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267003172 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267003173 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267003174 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267003175 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 234267003176 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 234267003177 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 234267003178 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 234267003179 active site 234267003180 homotetramer interface [polypeptide binding]; other site 234267003181 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 234267003182 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 234267003183 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 234267003184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267003185 S-adenosylmethionine binding site [chemical binding]; other site 234267003186 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 234267003187 active site clefts [active] 234267003188 zinc binding site [ion binding]; other site 234267003189 dimer interface [polypeptide binding]; other site 234267003190 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 234267003191 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 234267003192 HflX GTPase family; Region: HflX; cd01878 234267003193 G1 box; other site 234267003194 GTP/Mg2+ binding site [chemical binding]; other site 234267003195 Switch I region; other site 234267003196 G2 box; other site 234267003197 G3 box; other site 234267003198 Switch II region; other site 234267003199 G4 box; other site 234267003200 G5 box; other site 234267003201 bacterial Hfq-like; Region: Hfq; cd01716 234267003202 hexamer interface [polypeptide binding]; other site 234267003203 Sm1 motif; other site 234267003204 RNA binding site [nucleotide binding]; other site 234267003205 Sm2 motif; other site 234267003206 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267003207 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 234267003208 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 234267003209 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 234267003210 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 234267003211 Ligand binding site [chemical binding]; other site 234267003212 Electron transfer flavoprotein domain; Region: ETF; pfam01012 234267003213 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234267003214 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 234267003215 dimer interface [polypeptide binding]; other site 234267003216 active site 234267003217 acyl carrier protein; Provisional; Region: acpP; PRK00982 234267003218 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267003219 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234267003220 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267003221 Catalytic site [active] 234267003222 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267003223 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 234267003224 catalytic core [active] 234267003225 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 234267003226 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267003227 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 234267003228 Part of AAA domain; Region: AAA_19; pfam13245 234267003229 Family description; Region: UvrD_C_2; pfam13538 234267003230 amino acid transporter; Region: 2A0306; TIGR00909 234267003231 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 234267003232 Deoxyhypusine synthase; Region: DS; cl00826 234267003233 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 234267003234 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267003235 putative active site [active] 234267003236 metal binding site [ion binding]; metal-binding site 234267003237 homodimer binding site [polypeptide binding]; other site 234267003238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234267003239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234267003240 metal binding site [ion binding]; metal-binding site 234267003241 active site 234267003242 I-site; other site 234267003243 NHL repeat; Region: NHL; pfam01436 234267003244 NHL repeat; Region: NHL; pfam01436 234267003245 NHL repeat; Region: NHL; pfam01436 234267003246 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267003247 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267003248 tyrosine decarboxylase; Region: PLN02880 234267003249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267003250 catalytic residue [active] 234267003251 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267003252 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267003253 Trp docking motif [polypeptide binding]; other site 234267003254 putative active site [active] 234267003255 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267003256 hypothetical protein; Provisional; Region: PRK11239 234267003257 Protein of unknown function, DUF480; Region: DUF480; pfam04337 234267003258 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 234267003259 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267003260 hypothetical protein; Validated; Region: PRK06186 234267003261 conserved cys residue [active] 234267003262 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 234267003263 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003264 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 234267003265 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 234267003266 active site 234267003267 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 234267003268 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 234267003269 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 234267003270 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 234267003271 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 234267003272 putative active site [active] 234267003273 putative metal binding residues [ion binding]; other site 234267003274 signature motif; other site 234267003275 putative triphosphate binding site [ion binding]; other site 234267003276 dimer interface [polypeptide binding]; other site 234267003277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267003278 S-adenosylmethionine binding site [chemical binding]; other site 234267003279 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 234267003280 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 234267003281 PEP-CTERM motif; Region: VPEP; pfam07589 234267003282 Peptidase S46; Region: Peptidase_S46; pfam10459 234267003283 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267003284 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 234267003285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267003286 dimer interface [polypeptide binding]; other site 234267003287 ABC-ATPase subunit interface; other site 234267003288 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234267003289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267003290 Walker A/P-loop; other site 234267003291 ATP binding site [chemical binding]; other site 234267003292 Q-loop/lid; other site 234267003293 ABC transporter signature motif; other site 234267003294 Walker B; other site 234267003295 D-loop; other site 234267003296 H-loop/switch region; other site 234267003297 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 234267003298 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267003299 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267003300 C-terminal peptidase (prc); Region: prc; TIGR00225 234267003301 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 234267003302 protein binding site [polypeptide binding]; other site 234267003303 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 234267003304 Catalytic dyad [active] 234267003305 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267003306 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267003307 active site 234267003308 ATP binding site [chemical binding]; other site 234267003309 substrate binding site [chemical binding]; other site 234267003310 activation loop (A-loop); other site 234267003311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267003312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003313 TPR motif; other site 234267003314 binding surface 234267003315 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267003316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003317 binding surface 234267003318 TPR motif; other site 234267003319 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267003320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003321 TPR motif; other site 234267003322 binding surface 234267003323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267003324 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267003325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267003326 DNA binding residues [nucleotide binding] 234267003327 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267003328 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267003329 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267003330 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267003331 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267003332 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267003333 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267003334 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 234267003335 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 234267003336 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 234267003337 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 234267003338 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234267003339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267003340 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 234267003341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267003342 catalytic residue [active] 234267003343 TPR repeat; Region: TPR_11; pfam13414 234267003344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003345 binding surface 234267003346 TPR motif; other site 234267003347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003348 binding surface 234267003349 TPR motif; other site 234267003350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003351 binding surface 234267003352 TPR motif; other site 234267003353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003354 TPR motif; other site 234267003355 binding surface 234267003356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003357 binding surface 234267003358 TPR motif; other site 234267003359 TPR repeat; Region: TPR_11; pfam13414 234267003360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003361 TPR motif; other site 234267003362 binding surface 234267003363 TPR repeat; Region: TPR_11; pfam13414 234267003364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003365 TPR motif; other site 234267003366 binding surface 234267003367 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 234267003368 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 234267003369 23S rRNA binding site [nucleotide binding]; other site 234267003370 L21 binding site [polypeptide binding]; other site 234267003371 L13 binding site [polypeptide binding]; other site 234267003372 Cell division protein ZapA; Region: ZapA; pfam05164 234267003373 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 234267003374 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 234267003375 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234267003376 Zn2+ binding site [ion binding]; other site 234267003377 Mg2+ binding site [ion binding]; other site 234267003378 Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate...; Region: ZnMc_MMP; cd04278 234267003379 TIMP-binding surface; other site 234267003380 active site 234267003381 NHL repeat; Region: NHL; pfam01436 234267003382 NHL repeat; Region: NHL; pfam01436 234267003383 NHL repeat; Region: NHL; pfam01436 234267003384 NHL repeat; Region: NHL; pfam01436 234267003385 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267003386 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 234267003387 substrate binding site [chemical binding]; other site 234267003388 dimer interface [polypeptide binding]; other site 234267003389 ATP binding site [chemical binding]; other site 234267003390 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003391 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267003392 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267003393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267003394 S-adenosylmethionine binding site [chemical binding]; other site 234267003395 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 234267003396 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 234267003397 intersubunit interface [polypeptide binding]; other site 234267003398 active site 234267003399 Zn2+ binding site [ion binding]; other site 234267003400 ribulokinase; Provisional; Region: PRK04123 234267003401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234267003402 nucleotide binding site [chemical binding]; other site 234267003403 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 234267003404 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 234267003405 hexamer (dimer of trimers) interface [polypeptide binding]; other site 234267003406 substrate binding site [chemical binding]; other site 234267003407 trimer interface [polypeptide binding]; other site 234267003408 Mn binding site [ion binding]; other site 234267003409 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 234267003410 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 234267003411 Na binding site [ion binding]; other site 234267003412 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267003413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234267003414 DNA binding site [nucleotide binding] 234267003415 domain linker motif; other site 234267003416 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267003417 dimerization interface [polypeptide binding]; other site 234267003418 ligand binding site [chemical binding]; other site 234267003419 RNA polymerase sigma factor; Provisional; Region: PRK12513 234267003420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267003421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267003422 DNA binding residues [nucleotide binding] 234267003423 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 234267003424 dimer interface [polypeptide binding]; other site 234267003425 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267003426 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267003427 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267003428 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003429 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267003430 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267003431 Sulfatase; Region: Sulfatase; cl17466 234267003432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 234267003433 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 234267003434 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267003435 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267003436 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267003437 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267003438 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267003439 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267003440 Amino acid permease; Region: AA_permease_2; pfam13520 234267003441 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 234267003442 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267003443 active site 234267003444 metal binding site [ion binding]; metal-binding site 234267003445 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 234267003446 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 234267003447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 234267003448 active site residue [active] 234267003449 Pectinesterase; Region: Pectinesterase; pfam01095 234267003450 putative pectinesterase; Region: PLN02432; cl01911 234267003451 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 234267003452 active site 234267003453 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 234267003454 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267003455 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 234267003456 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 234267003457 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 234267003458 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 234267003459 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 234267003460 ligand binding site [chemical binding]; other site 234267003461 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267003462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003463 active site 234267003464 phosphorylation site [posttranslational modification] 234267003465 intermolecular recognition site; other site 234267003466 dimerization interface [polypeptide binding]; other site 234267003467 LytTr DNA-binding domain; Region: LytTR; pfam04397 234267003468 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 234267003469 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 234267003470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267003471 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 234267003472 putative NAD(P) binding site [chemical binding]; other site 234267003473 active site 234267003474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003475 binding surface 234267003476 TPR motif; other site 234267003477 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234267003478 DNA binding site [nucleotide binding] 234267003479 active site 234267003480 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 234267003481 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 234267003482 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 234267003483 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267003484 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 234267003485 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 234267003486 putative NADP binding site [chemical binding]; other site 234267003487 putative substrate binding site [chemical binding]; other site 234267003488 active site 234267003489 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 234267003490 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267003491 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 234267003492 putative NAD(P) binding site [chemical binding]; other site 234267003493 catalytic Zn binding site [ion binding]; other site 234267003494 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267003495 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267003496 NAD(P) binding site [chemical binding]; other site 234267003497 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 234267003498 active site lid residues [active] 234267003499 substrate binding pocket [chemical binding]; other site 234267003500 catalytic residues [active] 234267003501 substrate-Mg2+ binding site; other site 234267003502 aspartate-rich region 1; other site 234267003503 aspartate-rich region 2; other site 234267003504 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 234267003505 active site lid residues [active] 234267003506 substrate binding pocket [chemical binding]; other site 234267003507 catalytic residues [active] 234267003508 substrate-Mg2+ binding site; other site 234267003509 aspartate-rich region 1; other site 234267003510 aspartate-rich region 2; other site 234267003511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267003512 PAS domain; Region: PAS_9; pfam13426 234267003513 putative active site [active] 234267003514 heme pocket [chemical binding]; other site 234267003515 PAS domain S-box; Region: sensory_box; TIGR00229 234267003516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267003517 putative active site [active] 234267003518 heme pocket [chemical binding]; other site 234267003519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267003520 putative active site [active] 234267003521 heme pocket [chemical binding]; other site 234267003522 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 234267003523 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 234267003524 mce related protein; Region: MCE; pfam02470 234267003525 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267003526 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267003527 ligand binding site [chemical binding]; other site 234267003528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267003529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003530 active site 234267003531 phosphorylation site [posttranslational modification] 234267003532 intermolecular recognition site; other site 234267003533 dimerization interface [polypeptide binding]; other site 234267003534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267003535 DNA binding residues [nucleotide binding] 234267003536 dimerization interface [polypeptide binding]; other site 234267003537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267003538 Histidine kinase; Region: HisKA_3; pfam07730 234267003539 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234267003540 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267003541 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267003542 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267003543 Walker A/P-loop; other site 234267003544 ATP binding site [chemical binding]; other site 234267003545 Q-loop/lid; other site 234267003546 ABC transporter signature motif; other site 234267003547 Walker B; other site 234267003548 D-loop; other site 234267003549 H-loop/switch region; other site 234267003550 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 234267003551 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 234267003552 Preprotein translocase subunit; Region: YajC; pfam02699 234267003553 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 234267003554 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 234267003555 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 234267003556 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 234267003557 Protein export membrane protein; Region: SecD_SecF; pfam02355 234267003558 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267003559 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 234267003560 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 234267003561 TolR protein; Region: tolR; TIGR02801 234267003562 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 234267003563 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 234267003564 TPR repeat; Region: TPR_11; pfam13414 234267003565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003566 binding surface 234267003567 TPR motif; other site 234267003568 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 234267003569 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 234267003570 HD domain; Region: HD_4; pfam13328 234267003571 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 234267003572 synthetase active site [active] 234267003573 NTP binding site [chemical binding]; other site 234267003574 metal binding site [ion binding]; metal-binding site 234267003575 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 234267003576 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 234267003577 Protein of unknown function (DUF971); Region: DUF971; pfam06155 234267003578 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267003579 multifunctional aminopeptidase A; Provisional; Region: PRK00913 234267003580 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 234267003581 interface (dimer of trimers) [polypeptide binding]; other site 234267003582 Substrate-binding/catalytic site; other site 234267003583 Zn-binding sites [ion binding]; other site 234267003584 HEAT repeats; Region: HEAT_2; pfam13646 234267003585 HEAT repeats; Region: HEAT_2; pfam13646 234267003586 aconitate hydratase; Validated; Region: PRK09277 234267003587 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 234267003588 substrate binding site [chemical binding]; other site 234267003589 ligand binding site [chemical binding]; other site 234267003590 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 234267003591 substrate binding site [chemical binding]; other site 234267003592 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267003593 active site 234267003594 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 234267003595 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 234267003596 active site 234267003597 metal binding site [ion binding]; metal-binding site 234267003598 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 234267003599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003600 TPR motif; other site 234267003601 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267003602 binding surface 234267003603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003604 binding surface 234267003605 TPR motif; other site 234267003606 TPR repeat; Region: TPR_11; pfam13414 234267003607 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 234267003608 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 234267003609 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 234267003610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003611 TPR motif; other site 234267003612 binding surface 234267003613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003614 binding surface 234267003615 TPR motif; other site 234267003616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003617 binding surface 234267003618 TPR motif; other site 234267003619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003620 binding surface 234267003621 TPR motif; other site 234267003622 TPR repeat; Region: TPR_11; pfam13414 234267003623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003624 binding surface 234267003625 TPR motif; other site 234267003626 TPR repeat; Region: TPR_11; pfam13414 234267003627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267003628 Coenzyme A binding pocket [chemical binding]; other site 234267003629 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 234267003630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267003631 Uncharacterized conserved protein [Function unknown]; Region: COG3349 234267003632 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 234267003633 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267003634 active site 234267003635 ATP binding site [chemical binding]; other site 234267003636 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 234267003637 substrate binding site [chemical binding]; other site 234267003638 activation loop (A-loop); other site 234267003639 cyclase homology domain; Region: CHD; cd07302 234267003640 dimer interface [polypeptide binding]; other site 234267003641 nucleotidyl binding site; other site 234267003642 metal binding site [ion binding]; metal-binding site 234267003643 AAA ATPase domain; Region: AAA_16; pfam13191 234267003644 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267003646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267003647 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003648 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267003649 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403 234267003650 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 234267003651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267003652 FeS/SAM binding site; other site 234267003653 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 234267003654 UbiA prenyltransferase family; Region: UbiA; pfam01040 234267003655 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 234267003656 active site 234267003657 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267003658 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267003659 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267003660 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267003661 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 234267003662 ligand binding site [chemical binding]; other site 234267003663 flexible hinge region; other site 234267003664 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 234267003665 putative switch regulator; other site 234267003666 non-specific DNA interactions [nucleotide binding]; other site 234267003667 DNA binding site [nucleotide binding] 234267003668 sequence specific DNA binding site [nucleotide binding]; other site 234267003669 putative cAMP binding site [chemical binding]; other site 234267003670 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267003671 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267003672 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267003673 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267003674 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267003675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267003676 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267003677 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267003678 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267003679 ligand binding site [chemical binding]; other site 234267003680 flexible hinge region; other site 234267003681 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267003682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234267003683 metal ion-dependent adhesion site (MIDAS); other site 234267003684 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234267003685 Protein of unknown function (DUF3738); Region: DUF3738; pfam12543 234267003686 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234267003687 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234267003688 acyl-activating enzyme (AAE) consensus motif; other site 234267003689 AMP binding site [chemical binding]; other site 234267003690 active site 234267003691 CoA binding site [chemical binding]; other site 234267003692 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267003693 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267003694 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267003695 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267003696 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267003697 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267003698 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267003699 Winged helix-turn helix; Region: HTH_29; pfam13551 234267003700 DNA-binding interface [nucleotide binding]; DNA binding site 234267003701 Homeodomain-like domain; Region: HTH_32; pfam13565 234267003702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267003703 Integrase core domain; Region: rve; pfam00665 234267003704 Integrase core domain; Region: rve_3; pfam13683 234267003705 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 234267003706 Propanediol utilisation protein PduL; Region: PduL; pfam06130 234267003707 Propanediol utilisation protein PduL; Region: PduL; pfam06130 234267003708 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 234267003709 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 234267003710 Hexamer interface [polypeptide binding]; other site 234267003711 Hexagonal pore residue; other site 234267003712 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 234267003713 Hexamer interface [polypeptide binding]; other site 234267003714 Hexagonal pore residue; other site 234267003715 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 234267003716 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 234267003717 Hexamer interface [polypeptide binding]; other site 234267003718 Hexagonal pore residue; other site 234267003719 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 234267003720 NAD(P) binding site [chemical binding]; other site 234267003721 catalytic residues [active] 234267003722 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 234267003723 intersubunit interface [polypeptide binding]; other site 234267003724 active site 234267003725 Zn2+ binding site [ion binding]; other site 234267003726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 234267003727 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267003728 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267003729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267003730 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267003731 active site 234267003732 metal binding site [ion binding]; metal-binding site 234267003733 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267003734 active site 234267003735 metal binding site [ion binding]; metal-binding site 234267003736 Uncharacterized conserved protein [Function unknown]; Region: COG2128 234267003737 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234267003738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234267003739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267003740 Coenzyme A binding pocket [chemical binding]; other site 234267003741 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 234267003742 active site 234267003743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267003744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267003745 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267003746 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234267003747 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234267003748 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267003749 anti sigma factor interaction site; other site 234267003750 regulatory phosphorylation site [posttranslational modification]; other site 234267003751 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 234267003752 DNA polymerase I; Provisional; Region: PRK05755 234267003753 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 234267003754 active site 234267003755 metal binding site 1 [ion binding]; metal-binding site 234267003756 putative 5' ssDNA interaction site; other site 234267003757 metal binding site 3; metal-binding site 234267003758 metal binding site 2 [ion binding]; metal-binding site 234267003759 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 234267003760 putative DNA binding site [nucleotide binding]; other site 234267003761 putative metal binding site [ion binding]; other site 234267003762 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 234267003763 active site 234267003764 substrate binding site [chemical binding]; other site 234267003765 catalytic site [active] 234267003766 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 234267003767 active site 234267003768 DNA binding site [nucleotide binding] 234267003769 catalytic site [active] 234267003770 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267003771 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 234267003772 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 234267003773 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 234267003774 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234267003775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267003776 substrate binding pocket [chemical binding]; other site 234267003777 membrane-bound complex binding site; other site 234267003778 PAS domain S-box; Region: sensory_box; TIGR00229 234267003779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267003780 putative active site [active] 234267003781 heme pocket [chemical binding]; other site 234267003782 PAS domain S-box; Region: sensory_box; TIGR00229 234267003783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267003784 putative active site [active] 234267003785 heme pocket [chemical binding]; other site 234267003786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267003787 dimer interface [polypeptide binding]; other site 234267003788 phosphorylation site [posttranslational modification] 234267003789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267003790 ATP binding site [chemical binding]; other site 234267003791 Mg2+ binding site [ion binding]; other site 234267003792 G-X-G motif; other site 234267003793 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267003794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003795 active site 234267003796 phosphorylation site [posttranslational modification] 234267003797 intermolecular recognition site; other site 234267003798 dimerization interface [polypeptide binding]; other site 234267003799 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003800 YceI-like domain; Region: YceI; pfam04264 234267003801 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 234267003802 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 234267003803 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234267003804 inhibitor-cofactor binding pocket; inhibition site 234267003805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267003806 catalytic residue [active] 234267003807 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267003808 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234267003809 DNA binding site [nucleotide binding] 234267003810 domain linker motif; other site 234267003811 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267003812 dimerization interface [polypeptide binding]; other site 234267003813 ligand binding site [chemical binding]; other site 234267003814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267003815 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267003816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234267003817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267003818 NAD(P) binding site [chemical binding]; other site 234267003819 active site 234267003820 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234267003821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234267003822 acyl-activating enzyme (AAE) consensus motif; other site 234267003823 AMP binding site [chemical binding]; other site 234267003824 active site 234267003825 CoA binding site [chemical binding]; other site 234267003826 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 234267003827 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234267003828 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 234267003829 NAD(P) binding site [chemical binding]; other site 234267003830 catalytic residues [active] 234267003831 Radical SAM superfamily; Region: Radical_SAM; pfam04055 234267003832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267003833 FeS/SAM binding site; other site 234267003834 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 234267003835 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267003836 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267003837 DNA binding residues [nucleotide binding] 234267003838 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267003839 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267003840 active site 234267003841 ATP binding site [chemical binding]; other site 234267003842 substrate binding site [chemical binding]; other site 234267003843 activation loop (A-loop); other site 234267003844 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267003845 TPR repeat; Region: TPR_11; pfam13414 234267003846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003847 binding surface 234267003848 TPR motif; other site 234267003849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003850 TPR motif; other site 234267003851 binding surface 234267003852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003853 binding surface 234267003854 TPR motif; other site 234267003855 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 234267003856 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 234267003857 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 234267003858 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267003859 NAD binding site [chemical binding]; other site 234267003860 putative substrate binding site 2 [chemical binding]; other site 234267003861 putative substrate binding site 1 [chemical binding]; other site 234267003862 active site 234267003863 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 234267003864 Cysteine-rich domain; Region: CCG; pfam02754 234267003865 Cysteine-rich domain; Region: CCG; pfam02754 234267003866 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 234267003867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267003868 putative substrate translocation pore; other site 234267003869 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003870 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267003871 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 234267003872 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 234267003873 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267003874 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 234267003875 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267003876 4Fe-4S binding domain; Region: Fer4_6; pfam12837 234267003877 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 234267003878 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 234267003879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267003880 classical (c) SDRs; Region: SDR_c; cd05233 234267003881 NAD(P) binding site [chemical binding]; other site 234267003882 active site 234267003883 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234267003884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267003885 putative Zn2+ binding site [ion binding]; other site 234267003886 putative DNA binding site [nucleotide binding]; other site 234267003887 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267003888 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267003889 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267003890 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267003891 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 234267003892 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267003893 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 234267003894 Domain interface; other site 234267003895 Peptide binding site; other site 234267003896 Active site tetrad [active] 234267003897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267003898 TPR motif; other site 234267003899 binding surface 234267003900 TPR repeat; Region: TPR_11; pfam13414 234267003901 TPR repeat; Region: TPR_11; pfam13414 234267003902 TPR repeat; Region: TPR_11; pfam13414 234267003903 Tetratricopeptide repeat; Region: TPR_17; pfam13431 234267003904 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267003905 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267003906 Right handed beta helix region; Region: Beta_helix; pfam13229 234267003907 Right handed beta helix region; Region: Beta_helix; pfam13229 234267003908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267003909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267003910 S-adenosylmethionine binding site [chemical binding]; other site 234267003911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 234267003912 Walker A/P-loop; other site 234267003913 ATP binding site [chemical binding]; other site 234267003914 Walker B; other site 234267003915 D-loop; other site 234267003916 H-loop/switch region; other site 234267003917 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 234267003918 putative carbohydrate binding site [chemical binding]; other site 234267003919 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 234267003920 Fe-S cluster binding site [ion binding]; other site 234267003921 active site 234267003922 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 234267003923 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 234267003924 active site 234267003925 nucleophile elbow; other site 234267003926 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 234267003927 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 234267003928 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 234267003929 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267003930 active site 234267003931 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 234267003932 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 234267003933 ThiC family; Region: ThiC; pfam01964 234267003934 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 234267003935 BON domain; Region: BON; pfam04972 234267003936 BON domain; Region: BON; pfam04972 234267003937 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267003938 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267003939 metal ion-dependent adhesion site (MIDAS); other site 234267003940 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 234267003941 MPT binding site; other site 234267003942 trimer interface [polypeptide binding]; other site 234267003943 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 234267003944 trimer interface [polypeptide binding]; other site 234267003945 dimer interface [polypeptide binding]; other site 234267003946 putative active site [active] 234267003947 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 234267003948 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 234267003949 dimer interface [polypeptide binding]; other site 234267003950 putative functional site; other site 234267003951 putative MPT binding site; other site 234267003952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267003953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267003954 active site 234267003955 phosphorylation site [posttranslational modification] 234267003956 intermolecular recognition site; other site 234267003957 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267003958 DNA binding residues [nucleotide binding] 234267003959 dimerization interface [polypeptide binding]; other site 234267003960 PilZ domain; Region: PilZ; pfam07238 234267003961 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 234267003962 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 234267003963 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 234267003964 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 234267003965 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 234267003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 234267003967 active site 234267003968 phosphorylation site [posttranslational modification] 234267003969 AAA domain; Region: AAA_31; pfam13614 234267003970 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 234267003971 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 234267003972 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 234267003973 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 234267003974 ATP binding site [chemical binding]; other site 234267003975 Walker A motif; other site 234267003976 hexamer interface [polypeptide binding]; other site 234267003977 Walker B motif; other site 234267003978 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 234267003979 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267003980 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 234267003981 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267003982 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267003983 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267003984 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267003985 Uncharacterized conserved protein [Function unknown]; Region: COG2006 234267003986 Domain of unknown function (DUF362); Region: DUF362; pfam04015 234267003987 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234267003988 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267003989 phosphopeptide binding site; other site 234267003990 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 234267003991 cyclase homology domain; Region: CHD; cd07302 234267003992 nucleotidyl binding site; other site 234267003993 metal binding site [ion binding]; metal-binding site 234267003994 dimer interface [polypeptide binding]; other site 234267003995 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267003996 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 234267003997 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 234267003998 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 234267003999 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 234267004000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267004001 Walker A motif; other site 234267004002 ATP binding site [chemical binding]; other site 234267004003 Walker B motif; other site 234267004004 arginine finger; other site 234267004005 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267004006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267004007 ligand binding site [chemical binding]; other site 234267004008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267004009 TPR motif; other site 234267004010 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267004011 substrate binding site [chemical binding]; other site 234267004012 activation loop (A-loop); other site 234267004013 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267004014 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267004015 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267004016 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 234267004017 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267004018 DNA binding residues [nucleotide binding] 234267004019 putative dimer interface [polypeptide binding]; other site 234267004020 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 234267004021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267004022 putative NAD(P) binding site [chemical binding]; other site 234267004023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267004024 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 234267004025 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 234267004026 Protein of unknown function (DUF541); Region: SIMPL; cl01077 234267004027 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 234267004028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234267004029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 234267004030 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 234267004031 Ureide permease; Region: Ureide_permease; pfam07168 234267004032 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267004033 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267004034 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267004035 conserved hypothetical protein; Region: TIGR03843 234267004036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267004037 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 234267004038 active site 234267004039 metal binding site [ion binding]; metal-binding site 234267004040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004041 ATP binding site [chemical binding]; other site 234267004042 Mg2+ binding site [ion binding]; other site 234267004043 G-X-G motif; other site 234267004044 TLC ATP/ADP transporter; Region: TLC; cl03940 234267004045 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267004046 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267004047 ligand binding site [chemical binding]; other site 234267004048 flexible hinge region; other site 234267004049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267004050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004051 ATP binding site [chemical binding]; other site 234267004052 Mg2+ binding site [ion binding]; other site 234267004053 G-X-G motif; other site 234267004054 Response regulator receiver domain; Region: Response_reg; pfam00072 234267004055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004056 active site 234267004057 phosphorylation site [posttranslational modification] 234267004058 intermolecular recognition site; other site 234267004059 dimerization interface [polypeptide binding]; other site 234267004060 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 234267004061 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 234267004062 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 234267004063 Moco binding site; other site 234267004064 metal coordination site [ion binding]; other site 234267004065 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267004066 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267004067 catalytic residues [active] 234267004068 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 234267004069 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 234267004070 galactarate dehydratase; Region: galactar-dH20; TIGR03248 234267004071 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 234267004072 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 234267004073 Thioredoxin; Region: Thioredoxin_4; pfam13462 234267004074 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234267004075 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267004076 PA_M28_1_3: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 3. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_3; cd04822 234267004077 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267004078 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 234267004079 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267004080 metal binding site [ion binding]; metal-binding site 234267004081 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267004082 Response regulator receiver domain; Region: Response_reg; pfam00072 234267004083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004084 active site 234267004085 phosphorylation site [posttranslational modification] 234267004086 intermolecular recognition site; other site 234267004087 dimerization interface [polypeptide binding]; other site 234267004088 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 234267004089 active site 234267004090 catalytic residues [active] 234267004091 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 234267004092 NmrA-like family; Region: NmrA; pfam05368 234267004093 NAD(P) binding site [chemical binding]; other site 234267004094 putative active site [active] 234267004095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267004096 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004098 active site 234267004099 phosphorylation site [posttranslational modification] 234267004100 intermolecular recognition site; other site 234267004101 dimerization interface [polypeptide binding]; other site 234267004102 LytTr DNA-binding domain; Region: LytTR; smart00850 234267004103 Histidine kinase; Region: His_kinase; pfam06580 234267004104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004105 ATP binding site [chemical binding]; other site 234267004106 Mg2+ binding site [ion binding]; other site 234267004107 G-X-G motif; other site 234267004108 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267004109 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 234267004110 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267004111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267004112 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267004113 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267004114 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004115 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004116 FtsX-like permease family; Region: FtsX; pfam02687 234267004117 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 234267004118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267004119 alpha-galactosidase; Region: PLN02808; cl17638 234267004120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267004121 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267004122 putative substrate translocation pore; other site 234267004123 Domain of unknown function (DUF955); Region: DUF955; cl01076 234267004124 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267004125 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267004126 catalytic residues [active] 234267004127 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 234267004128 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 234267004129 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 234267004130 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 234267004131 potential catalytic triad [active] 234267004132 conserved cys residue [active] 234267004133 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004134 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267004135 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267004136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267004137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234267004138 DNA binding site [nucleotide binding] 234267004139 domain linker motif; other site 234267004140 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267004141 dimerization interface [polypeptide binding]; other site 234267004142 ligand binding site [chemical binding]; other site 234267004143 KduI/IolB family; Region: KduI; pfam04962 234267004144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267004145 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 234267004146 substrate binding site [chemical binding]; other site 234267004147 ATP binding site [chemical binding]; other site 234267004148 Class I aldolases; Region: Aldolase_Class_I; cl17187 234267004149 catalytic residue [active] 234267004150 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 234267004151 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234267004152 PYR/PP interface [polypeptide binding]; other site 234267004153 dimer interface [polypeptide binding]; other site 234267004154 TPP binding site [chemical binding]; other site 234267004155 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267004156 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 234267004157 TPP-binding site; other site 234267004158 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267004159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267004160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267004161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267004162 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 234267004163 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 234267004164 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267004165 catalytic residues [active] 234267004166 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267004167 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 234267004168 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 234267004169 G1 box; other site 234267004170 putative GEF interaction site [polypeptide binding]; other site 234267004171 GTP/Mg2+ binding site [chemical binding]; other site 234267004172 Switch I region; other site 234267004173 G2 box; other site 234267004174 G3 box; other site 234267004175 Switch II region; other site 234267004176 G4 box; other site 234267004177 G5 box; other site 234267004178 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 234267004179 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 234267004180 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 234267004181 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 234267004182 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 234267004183 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 234267004184 ligand binding site; other site 234267004185 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 234267004186 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234267004187 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234267004188 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234267004189 hypothetical protein; Provisional; Region: PRK07906 234267004190 putative metal binding site [ion binding]; other site 234267004191 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234267004192 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234267004193 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267004194 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267004195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267004196 Walker A/P-loop; other site 234267004197 ATP binding site [chemical binding]; other site 234267004198 Q-loop/lid; other site 234267004199 ABC transporter signature motif; other site 234267004200 Walker B; other site 234267004201 D-loop; other site 234267004202 H-loop/switch region; other site 234267004203 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 234267004204 LexA repressor; Validated; Region: PRK00215 234267004205 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 234267004206 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 234267004207 Catalytic site [active] 234267004208 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 234267004209 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 234267004210 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 234267004211 dimer interface [polypeptide binding]; other site 234267004212 active site residues [active] 234267004213 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 234267004214 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234267004215 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 234267004216 Sporulation related domain; Region: SPOR; pfam05036 234267004217 lipoyl synthase; Provisional; Region: PRK05481 234267004218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267004219 FeS/SAM binding site; other site 234267004220 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 234267004221 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 234267004222 putative active site [active] 234267004223 catalytic triad [active] 234267004224 putative dimer interface [polypeptide binding]; other site 234267004225 Transposase; Region: HTH_Tnp_1; cl17663 234267004226 putative transposase OrfB; Reviewed; Region: PHA02517 234267004227 HTH-like domain; Region: HTH_21; pfam13276 234267004228 Integrase core domain; Region: rve; pfam00665 234267004229 Integrase core domain; Region: rve_3; pfam13683 234267004230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267004231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267004232 active site 234267004233 catalytic tetrad [active] 234267004234 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 234267004235 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004236 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 234267004237 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267004238 Predicted membrane protein [Function unknown]; Region: COG4485 234267004239 Predicted integral membrane protein [Function unknown]; Region: COG5617 234267004240 Predicted integral membrane protein [Function unknown]; Region: COG5617 234267004241 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 234267004242 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267004243 metal binding site [ion binding]; metal-binding site 234267004244 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267004245 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267004246 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267004247 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 234267004248 SurA N-terminal domain; Region: SurA_N_3; cl07813 234267004249 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 234267004250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267004251 S-adenosylmethionine binding site [chemical binding]; other site 234267004252 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 234267004253 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 234267004254 Moco binding site; other site 234267004255 metal coordination site [ion binding]; other site 234267004256 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004257 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004258 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 234267004259 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004260 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004261 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004262 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267004263 Sulfatase; Region: Sulfatase; pfam00884 234267004264 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 234267004265 tartrate dehydrogenase; Region: TTC; TIGR02089 234267004266 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 234267004267 MviN-like protein; Region: MVIN; pfam03023 234267004268 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 234267004269 putative active site [active] 234267004270 Zn binding site [ion binding]; other site 234267004271 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267004272 conserved cys residue [active] 234267004273 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 234267004274 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 234267004275 active site 234267004276 Zn binding site [ion binding]; other site 234267004277 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234267004278 Peptidase family M23; Region: Peptidase_M23; pfam01551 234267004279 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267004280 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267004281 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267004282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267004283 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 234267004284 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 234267004285 dimer interface [polypeptide binding]; other site 234267004286 motif 1; other site 234267004287 active site 234267004288 motif 2; other site 234267004289 motif 3; other site 234267004290 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 234267004291 anticodon binding site; other site 234267004292 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 234267004293 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 234267004294 dimer interface [polypeptide binding]; other site 234267004295 anticodon binding site; other site 234267004296 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 234267004297 homodimer interface [polypeptide binding]; other site 234267004298 motif 1; other site 234267004299 active site 234267004300 motif 2; other site 234267004301 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 234267004302 motif 3; other site 234267004303 Nudix hydrolase homolog; Region: PLN02791 234267004304 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267004305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267004306 Helix-Turn-Helix DNA binding domain of putative Cfa-like transcription regulators; Region: HTH_Cfa-like_unk; cd04790 234267004307 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267004308 DNA binding residues [nucleotide binding] 234267004309 putative dimer interface [polypeptide binding]; other site 234267004310 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267004311 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267004312 Walker A/P-loop; other site 234267004313 ATP binding site [chemical binding]; other site 234267004314 Q-loop/lid; other site 234267004315 ABC transporter signature motif; other site 234267004316 Walker B; other site 234267004317 D-loop; other site 234267004318 H-loop/switch region; other site 234267004319 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 234267004320 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 234267004321 N-terminal plug; other site 234267004322 ligand-binding site [chemical binding]; other site 234267004323 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 234267004324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267004325 dimerization interface [polypeptide binding]; other site 234267004326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267004327 dimer interface [polypeptide binding]; other site 234267004328 phosphorylation site [posttranslational modification] 234267004329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004330 ATP binding site [chemical binding]; other site 234267004331 Mg2+ binding site [ion binding]; other site 234267004332 G-X-G motif; other site 234267004333 Response regulator receiver domain; Region: Response_reg; pfam00072 234267004334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004335 active site 234267004336 phosphorylation site [posttranslational modification] 234267004337 intermolecular recognition site; other site 234267004338 dimerization interface [polypeptide binding]; other site 234267004339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267004340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004341 active site 234267004342 phosphorylation site [posttranslational modification] 234267004343 intermolecular recognition site; other site 234267004344 dimerization interface [polypeptide binding]; other site 234267004345 malate dehydrogenase; Reviewed; Region: PRK06223 234267004346 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 234267004347 dimer interface [polypeptide binding]; other site 234267004348 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234267004349 NAD(P) binding site [chemical binding]; other site 234267004350 substrate binding site [chemical binding]; other site 234267004351 Phospholipase B; Region: Phospholip_B; pfam04916 234267004352 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 234267004353 NHL repeat; Region: NHL; pfam01436 234267004354 NHL repeat; Region: NHL; pfam01436 234267004355 NHL repeat; Region: NHL; pfam01436 234267004356 NHL repeat; Region: NHL; pfam01436 234267004357 NHL repeat; Region: NHL; pfam01436 234267004358 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267004359 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 234267004360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267004361 motif II; other site 234267004362 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 234267004363 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 234267004364 putative active site; other site 234267004365 catalytic triad [active] 234267004366 putative dimer interface [polypeptide binding]; other site 234267004367 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 234267004368 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 234267004369 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267004370 Active site serine [active] 234267004371 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267004372 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 234267004373 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267004374 putative NAD(P) binding site [chemical binding]; other site 234267004375 catalytic Zn binding site [ion binding]; other site 234267004376 structural Zn binding site [ion binding]; other site 234267004377 threonine synthase; Validated; Region: PRK06260 234267004378 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 234267004379 homodimer interface [polypeptide binding]; other site 234267004380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267004381 catalytic residue [active] 234267004382 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267004383 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267004384 catalytic residues [active] 234267004385 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267004386 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267004387 catalytic residues [active] 234267004388 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 234267004389 active site 234267004390 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 234267004391 active site 234267004392 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 234267004393 homodecamer interface [polypeptide binding]; other site 234267004394 GTP cyclohydrolase I; Provisional; Region: PLN03044 234267004395 active site 234267004396 putative catalytic site residues [active] 234267004397 zinc binding site [ion binding]; other site 234267004398 GTP-CH-I/GFRP interaction surface; other site 234267004399 XapX domain; Region: XapX; TIGR03510 234267004400 competence damage-inducible protein A; Provisional; Region: PRK00549 234267004401 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 234267004402 putative MPT binding site; other site 234267004403 Competence-damaged protein; Region: CinA; pfam02464 234267004404 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 234267004405 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 234267004406 tetramer interfaces [polypeptide binding]; other site 234267004407 binuclear metal-binding site [ion binding]; other site 234267004408 Domain of unknown function (DUF329); Region: DUF329; pfam03884 234267004409 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 234267004410 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 234267004411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267004412 FeS/SAM binding site; other site 234267004413 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 234267004414 putative hydrophobic ligand binding site [chemical binding]; other site 234267004415 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267004416 dimerization interface [polypeptide binding]; other site 234267004417 putative DNA binding site [nucleotide binding]; other site 234267004418 putative Zn2+ binding site [ion binding]; other site 234267004419 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 234267004420 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267004421 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 234267004422 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 234267004423 Protein export membrane protein; Region: SecD_SecF; cl14618 234267004424 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 234267004425 Protein export membrane protein; Region: SecD_SecF; cl14618 234267004426 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267004427 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267004428 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267004429 Predicted acyl esterases [General function prediction only]; Region: COG2936 234267004430 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 234267004431 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 234267004432 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 234267004433 This domain is found in peptide chain release factors; Region: PCRF; smart00937 234267004434 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 234267004435 RF-1 domain; Region: RF-1; pfam00472 234267004436 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267004437 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267004438 active site 234267004439 metal binding site [ion binding]; metal-binding site 234267004440 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 234267004441 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234267004442 Walker A motif; other site 234267004443 ATP binding site [chemical binding]; other site 234267004444 Walker B motif; other site 234267004445 alpha-galactosidase; Region: PLN02808; cl17638 234267004446 Family description; Region: VCBS; pfam13517 234267004447 Family description; Region: VCBS; pfam13517 234267004448 Family description; Region: VCBS; pfam13517 234267004449 Family description; Region: VCBS; pfam13517 234267004450 Family description; Region: VCBS; pfam13517 234267004451 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267004452 TPR repeat; Region: TPR_11; pfam13414 234267004453 TPR repeat; Region: TPR_11; pfam13414 234267004454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004455 binding surface 234267004456 TPR motif; other site 234267004457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004458 TPR motif; other site 234267004459 binding surface 234267004460 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004464 binding surface 234267004465 TPR motif; other site 234267004466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004468 binding surface 234267004469 TPR motif; other site 234267004470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004472 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004474 binding surface 234267004475 TPR motif; other site 234267004476 FG-GAP repeat; Region: FG-GAP; pfam01839 234267004477 Family description; Region: VCBS; pfam13517 234267004478 Family description; Region: VCBS; pfam13517 234267004479 Family description; Region: VCBS; pfam13517 234267004480 Family description; Region: VCBS; pfam13517 234267004481 Family description; Region: VCBS; pfam13517 234267004482 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267004483 Predicted transcriptional regulators [Transcription]; Region: COG1725 234267004484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267004485 DNA-binding site [nucleotide binding]; DNA binding site 234267004486 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234267004487 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 234267004488 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 234267004489 putative amphipathic alpha helix; other site 234267004490 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 234267004491 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 234267004492 dimer interface [polypeptide binding]; other site 234267004493 active site 234267004494 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 234267004495 dimer interface [polypeptide binding]; other site 234267004496 active site 234267004497 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267004498 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 234267004499 Domain interface; other site 234267004500 Peptide binding site; other site 234267004501 Active site tetrad [active] 234267004502 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 234267004503 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234267004504 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234267004505 Ycf46; Provisional; Region: ycf46; CHL00195 234267004506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267004507 Walker A motif; other site 234267004508 ATP binding site [chemical binding]; other site 234267004509 Walker B motif; other site 234267004510 arginine finger; other site 234267004511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267004512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004513 active site 234267004514 phosphorylation site [posttranslational modification] 234267004515 intermolecular recognition site; other site 234267004516 dimerization interface [polypeptide binding]; other site 234267004517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267004518 DNA binding residues [nucleotide binding] 234267004519 dimerization interface [polypeptide binding]; other site 234267004520 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 234267004521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267004522 Histidine kinase; Region: HisKA_3; pfam07730 234267004523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004524 ATP binding site [chemical binding]; other site 234267004525 Mg2+ binding site [ion binding]; other site 234267004526 G-X-G motif; other site 234267004527 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234267004528 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 234267004529 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004530 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267004531 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 234267004532 PAAR motif; Region: PAAR_motif; pfam05488 234267004533 TIR domain; Region: TIR_2; pfam13676 234267004534 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 234267004535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004536 TPR motif; other site 234267004537 binding surface 234267004538 TPR repeat; Region: TPR_11; pfam13414 234267004539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004540 binding surface 234267004541 TPR motif; other site 234267004542 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267004543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004544 binding surface 234267004545 TPR motif; other site 234267004546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004547 binding surface 234267004548 TPR motif; other site 234267004549 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004550 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267004551 Winged helix-turn helix; Region: HTH_29; pfam13551 234267004552 putative transposase OrfB; Reviewed; Region: PHA02517 234267004553 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 234267004554 Integrase core domain; Region: rve; pfam00665 234267004555 Integrase core domain; Region: rve_3; pfam13683 234267004556 Transposase; Region: HTH_Tnp_1; pfam01527 234267004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267004558 putative transposase OrfB; Reviewed; Region: PHA02517 234267004559 HTH-like domain; Region: HTH_21; pfam13276 234267004560 Integrase core domain; Region: rve; pfam00665 234267004561 Integrase core domain; Region: rve_3; pfam13683 234267004562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267004563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267004564 active site 234267004565 ATP binding site [chemical binding]; other site 234267004566 substrate binding site [chemical binding]; other site 234267004567 activation loop (A-loop); other site 234267004568 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267004569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267004570 DNA binding residues [nucleotide binding] 234267004571 WYL domain; Region: WYL; cl14852 234267004572 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234267004573 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234267004574 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 234267004575 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 234267004576 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267004577 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267004578 Trp docking motif [polypeptide binding]; other site 234267004579 putative active site [active] 234267004580 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267004581 putative active site [active] 234267004582 Zn binding site [ion binding]; other site 234267004583 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 234267004584 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 234267004585 active site 234267004586 substrate binding site [chemical binding]; other site 234267004587 FMN binding site [chemical binding]; other site 234267004588 putative catalytic residues [active] 234267004589 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004590 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267004591 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267004592 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267004593 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 234267004594 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004595 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267004596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004597 active site 234267004598 phosphorylation site [posttranslational modification] 234267004599 intermolecular recognition site; other site 234267004600 dimerization interface [polypeptide binding]; other site 234267004601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267004602 Walker A motif; other site 234267004603 ATP binding site [chemical binding]; other site 234267004604 Walker B motif; other site 234267004605 arginine finger; other site 234267004606 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 234267004607 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267004608 GAF domain; Region: GAF_3; pfam13492 234267004609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267004610 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267004611 putative active site [active] 234267004612 heme pocket [chemical binding]; other site 234267004613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267004614 dimer interface [polypeptide binding]; other site 234267004615 phosphorylation site [posttranslational modification] 234267004616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004617 ATP binding site [chemical binding]; other site 234267004618 Mg2+ binding site [ion binding]; other site 234267004619 G-X-G motif; other site 234267004620 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 234267004621 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 234267004622 SLBB domain; Region: SLBB; pfam10531 234267004623 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 234267004624 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 234267004625 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267004626 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234267004627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234267004628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004630 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004631 binding surface 234267004632 TPR motif; other site 234267004633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004634 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004636 binding surface 234267004637 TPR motif; other site 234267004638 CHAT domain; Region: CHAT; pfam12770 234267004639 Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is...; Region: CaCS_like; cd06116 234267004640 dimer interface [polypeptide binding]; other site 234267004641 Citrate synthase; Region: Citrate_synt; pfam00285 234267004642 active site 234267004643 citrylCoA binding site [chemical binding]; other site 234267004644 oxalacetate/citrate binding site [chemical binding]; other site 234267004645 coenzyme A binding site [chemical binding]; other site 234267004646 catalytic triad [active] 234267004647 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 234267004648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004649 FtsX-like permease family; Region: FtsX; pfam02687 234267004650 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004651 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267004652 FtsX-like permease family; Region: FtsX; pfam02687 234267004653 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267004654 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267004655 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267004656 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267004657 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267004658 Walker A/P-loop; other site 234267004659 ATP binding site [chemical binding]; other site 234267004660 Q-loop/lid; other site 234267004661 ABC transporter signature motif; other site 234267004662 Walker B; other site 234267004663 D-loop; other site 234267004664 H-loop/switch region; other site 234267004665 OPT oligopeptide transporter protein; Region: OPT; cl14607 234267004666 putative oligopeptide transporter, OPT family; Region: TIGR00733 234267004667 Yqey-like protein; Region: YqeY; cl17540 234267004668 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 234267004669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267004670 catalytic residue [active] 234267004671 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 234267004672 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 234267004673 ligand binding site [chemical binding]; other site 234267004674 NAD binding site [chemical binding]; other site 234267004675 dimerization interface [polypeptide binding]; other site 234267004676 catalytic site [active] 234267004677 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 234267004678 putative L-serine binding site [chemical binding]; other site 234267004679 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267004680 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267004681 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004682 FtsX-like permease family; Region: FtsX; pfam02687 234267004683 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004684 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 234267004685 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 234267004686 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 234267004687 active site 234267004688 dimer interface [polypeptide binding]; other site 234267004689 effector binding site; other site 234267004690 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 234267004691 TSCPD domain; Region: TSCPD; pfam12637 234267004692 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 234267004693 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234267004694 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 234267004695 catalytic residues [active] 234267004696 catalytic nucleophile [active] 234267004697 Recombinase; Region: Recombinase; pfam07508 234267004698 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 234267004699 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 234267004700 Virulence-associated protein E; Region: VirE; pfam05272 234267004701 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 234267004702 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 234267004703 active site 234267004704 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 234267004705 ABC1 family; Region: ABC1; cl17513 234267004706 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 234267004707 active site 234267004708 ATP binding site [chemical binding]; other site 234267004709 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 234267004710 catalytic loop [active] 234267004711 activation loop (A-loop); other site 234267004712 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 234267004713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267004714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267004715 catalytic residue [active] 234267004716 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234267004717 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 234267004718 iron-sulfur cluster [ion binding]; other site 234267004719 [2Fe-2S] cluster binding site [ion binding]; other site 234267004720 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 234267004721 hydrophobic ligand binding site; other site 234267004722 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 234267004723 Uncharacterized conserved protein [Function unknown]; Region: COG4938 234267004724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267004725 Walker A/P-loop; other site 234267004726 ATP binding site [chemical binding]; other site 234267004727 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 234267004728 Protein of unknown function DUF262; Region: DUF262; pfam03235 234267004729 Protein of unknown function DUF262; Region: DUF262; pfam03235 234267004730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267004731 ATP binding site [chemical binding]; other site 234267004732 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 234267004733 putative Mg++ binding site [ion binding]; other site 234267004734 AAA domain; Region: AAA_12; pfam13087 234267004735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267004736 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267004737 Walker A motif; other site 234267004738 ATP binding site [chemical binding]; other site 234267004739 Walker B motif; other site 234267004740 arginine finger; other site 234267004741 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 234267004742 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 234267004743 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 234267004744 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 234267004745 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 234267004746 additional DNA contacts [nucleotide binding]; other site 234267004747 active site 234267004748 zinc binding site [ion binding]; other site 234267004749 DNA intercalation site [nucleotide binding]; other site 234267004750 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 234267004751 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 234267004752 cofactor binding site; other site 234267004753 DNA binding site [nucleotide binding] 234267004754 substrate interaction site [chemical binding]; other site 234267004755 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 234267004756 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 234267004757 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 234267004758 Part of AAA domain; Region: AAA_19; pfam13245 234267004759 Family description; Region: UvrD_C_2; pfam13538 234267004760 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 234267004761 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 234267004762 Family description; Region: UvrD_C_2; pfam13538 234267004763 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 234267004764 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234267004765 minor groove reading motif; other site 234267004766 helix-hairpin-helix signature motif; other site 234267004767 substrate binding pocket [chemical binding]; other site 234267004768 active site 234267004769 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 234267004770 Restriction endonuclease; Region: Mrr_cat; pfam04471 234267004771 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 234267004772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267004773 ATP binding site [chemical binding]; other site 234267004774 putative Mg++ binding site [ion binding]; other site 234267004775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267004776 nucleotide binding region [chemical binding]; other site 234267004777 ATP-binding site [chemical binding]; other site 234267004778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004779 ATP binding site [chemical binding]; other site 234267004780 Mg2+ binding site [ion binding]; other site 234267004781 G-X-G motif; other site 234267004782 Double zinc ribbon; Region: DZR; pfam12773 234267004783 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 234267004784 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 234267004785 cofactor binding site; other site 234267004786 DNA binding site [nucleotide binding] 234267004787 substrate interaction site [chemical binding]; other site 234267004788 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 234267004789 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 234267004790 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267004791 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267004792 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 234267004793 putative substrate binding site [chemical binding]; other site 234267004794 putative ATP binding site [chemical binding]; other site 234267004795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004796 TPR motif; other site 234267004797 TPR repeat; Region: TPR_11; pfam13414 234267004798 binding surface 234267004799 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 234267004800 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 234267004801 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 234267004802 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 234267004803 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 234267004804 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 234267004805 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 234267004806 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 234267004807 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 234267004808 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267004809 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 234267004810 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004811 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267004812 FtsX-like permease family; Region: FtsX; pfam02687 234267004813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004814 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267004815 FtsX-like permease family; Region: FtsX; pfam02687 234267004816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267004818 binding surface 234267004819 TPR motif; other site 234267004820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267004822 Tetratricopeptide repeat; Region: TPR_10; pfam13374 234267004823 CHAT domain; Region: CHAT; pfam12770 234267004824 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267004825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267004826 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267004827 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 234267004828 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 234267004829 tetramer interface [polypeptide binding]; other site 234267004830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267004831 catalytic residue [active] 234267004832 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267004833 PEP-CTERM motif; Region: VPEP; pfam07589 234267004834 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267004835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004836 TPR motif; other site 234267004837 binding surface 234267004838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004839 TPR motif; other site 234267004840 binding surface 234267004841 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267004842 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267004843 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267004844 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267004845 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267004846 Amidinotransferase; Region: Amidinotransf; cl12043 234267004847 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267004848 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267004849 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267004850 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004851 FtsX-like permease family; Region: FtsX; pfam02687 234267004852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004853 FtsX-like permease family; Region: FtsX; pfam02687 234267004854 alpha-dioxygenase; Region: PLN02283 234267004855 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 234267004856 putative heme binding site [chemical binding]; other site 234267004857 putative active site [active] 234267004858 putative substrate binding site [chemical binding]; other site 234267004859 short chain dehydrogenase; Provisional; Region: PRK06123 234267004860 classical (c) SDRs; Region: SDR_c; cd05233 234267004861 NAD(P) binding site [chemical binding]; other site 234267004862 active site 234267004863 galactarate dehydratase; Region: galactar-dH20; TIGR03248 234267004864 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 234267004865 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 234267004866 Cytochrome c; Region: Cytochrom_C; pfam00034 234267004867 Cytochrome c; Region: Cytochrom_C; pfam00034 234267004868 Cytochrome c; Region: Cytochrom_C; pfam00034 234267004869 Family description; Region: VCBS; pfam13517 234267004870 Family description; Region: VCBS; pfam13517 234267004871 Family description; Region: VCBS; pfam13517 234267004872 Family description; Region: VCBS; pfam13517 234267004873 Family description; Region: VCBS; pfam13517 234267004874 Family description; Region: VCBS; pfam13517 234267004875 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267004876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004877 TPR motif; other site 234267004878 TPR repeat; Region: TPR_11; pfam13414 234267004879 binding surface 234267004880 TPR repeat; Region: TPR_11; pfam13414 234267004881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004882 binding surface 234267004883 TPR motif; other site 234267004884 TPR repeat; Region: TPR_11; pfam13414 234267004885 TPR repeat; Region: TPR_11; pfam13414 234267004886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267004887 binding surface 234267004888 TPR motif; other site 234267004889 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004890 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234267004891 L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388 234267004892 Multicopper oxidase; Region: Cu-oxidase; pfam00394 234267004893 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234267004894 Protein of unknown function (DUF445); Region: DUF445; pfam04286 234267004895 hypothetical protein; Provisional; Region: PRK09133 234267004896 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234267004897 putative metal binding site [ion binding]; other site 234267004898 PX-associated; Region: PXB; pfam12828 234267004899 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 234267004900 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267004901 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234267004902 substrate binding pocket [chemical binding]; other site 234267004903 membrane-bound complex binding site; other site 234267004904 hinge residues; other site 234267004905 PAS fold; Region: PAS_4; pfam08448 234267004906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267004907 putative active site [active] 234267004908 heme pocket [chemical binding]; other site 234267004909 PAS domain S-box; Region: sensory_box; TIGR00229 234267004910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267004911 putative active site [active] 234267004912 heme pocket [chemical binding]; other site 234267004913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267004914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267004915 dimer interface [polypeptide binding]; other site 234267004916 phosphorylation site [posttranslational modification] 234267004917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267004918 ATP binding site [chemical binding]; other site 234267004919 Mg2+ binding site [ion binding]; other site 234267004920 G-X-G motif; other site 234267004921 Response regulator receiver domain; Region: Response_reg; pfam00072 234267004922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004923 active site 234267004924 phosphorylation site [posttranslational modification] 234267004925 intermolecular recognition site; other site 234267004926 dimerization interface [polypeptide binding]; other site 234267004927 Response regulator receiver domain; Region: Response_reg; pfam00072 234267004928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004929 active site 234267004930 phosphorylation site [posttranslational modification] 234267004931 intermolecular recognition site; other site 234267004932 dimerization interface [polypeptide binding]; other site 234267004933 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267004934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004935 active site 234267004936 phosphorylation site [posttranslational modification] 234267004937 intermolecular recognition site; other site 234267004938 dimerization interface [polypeptide binding]; other site 234267004939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267004940 Walker A motif; other site 234267004941 ATP binding site [chemical binding]; other site 234267004942 Walker B motif; other site 234267004943 arginine finger; other site 234267004944 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267004945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267004946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267004947 active site 234267004948 phosphorylation site [posttranslational modification] 234267004949 intermolecular recognition site; other site 234267004950 dimerization interface [polypeptide binding]; other site 234267004951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267004952 DNA binding residues [nucleotide binding] 234267004953 dimerization interface [polypeptide binding]; other site 234267004954 Predicted transcriptional regulators [Transcription]; Region: COG1378 234267004955 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 234267004956 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 234267004957 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267004958 DNA binding residues [nucleotide binding] 234267004959 dimer interface [polypeptide binding]; other site 234267004960 metal binding site [ion binding]; metal-binding site 234267004961 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 234267004962 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 234267004963 Ligand binding site; other site 234267004964 Putative Catalytic site; other site 234267004965 DXD motif; other site 234267004966 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234267004967 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 234267004968 putative ligand binding pocket/active site [active] 234267004969 putative metal binding site [ion binding]; other site 234267004970 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 234267004971 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 234267004972 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 234267004973 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267004974 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267004975 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267004976 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004977 FtsX-like permease family; Region: FtsX; pfam02687 234267004978 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267004979 FtsX-like permease family; Region: FtsX; pfam02687 234267004980 FtsX-like permease family; Region: FtsX; pfam02687 234267004981 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267004982 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 234267004983 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 234267004984 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 234267004985 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 234267004986 putative active site [active] 234267004987 homotetrameric interface [polypeptide binding]; other site 234267004988 metal binding site [ion binding]; metal-binding site 234267004989 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004990 PEP-CTERM motif; Region: VPEP; pfam07589 234267004991 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 234267004992 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 234267004993 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267004994 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267004995 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267004996 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267004997 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234267004998 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234267004999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 234267005000 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234267005001 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234267005002 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 234267005003 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 234267005004 active site 234267005005 substrate binding site [chemical binding]; other site 234267005006 FMN binding site [chemical binding]; other site 234267005007 putative catalytic residues [active] 234267005008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 234267005009 Putative glucoamylase; Region: Glycoamylase; pfam10091 234267005010 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 234267005011 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 234267005012 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 234267005013 TPP-binding site; other site 234267005014 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234267005015 PYR/PP interface [polypeptide binding]; other site 234267005016 dimer interface [polypeptide binding]; other site 234267005017 TPP binding site [chemical binding]; other site 234267005018 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267005019 short chain dehydrogenase; Provisional; Region: PRK08278 234267005020 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 234267005021 NAD(P) binding site [chemical binding]; other site 234267005022 homodimer interface [polypeptide binding]; other site 234267005023 active site 234267005024 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234267005025 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234267005026 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 234267005027 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 234267005028 NAD(P) binding site [chemical binding]; other site 234267005029 catalytic residues [active] 234267005030 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 234267005031 nucleophilic elbow; other site 234267005032 catalytic triad; other site 234267005033 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 234267005034 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 234267005035 ABC1 family; Region: ABC1; cl17513 234267005036 Amino acid permease; Region: AA_permease_2; pfam13520 234267005037 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 234267005038 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267005039 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267005040 Amidohydrolase; Region: Amidohydro_4; pfam13147 234267005041 active site 234267005042 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 234267005043 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 234267005044 active site 234267005045 catalytic site [active] 234267005046 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 234267005047 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267005049 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234267005050 NAD(P) binding site [chemical binding]; other site 234267005051 active site 234267005052 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 234267005053 Methane oxygenase PmoA; Region: PmoA; pfam14100 234267005054 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267005055 Ligand binding site; other site 234267005056 Putative Catalytic site; other site 234267005057 DXD motif; other site 234267005058 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267005059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267005060 S-adenosylmethionine binding site [chemical binding]; other site 234267005061 ribonuclease III; Reviewed; Region: rnc; PRK00102 234267005062 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 234267005063 dimerization interface [polypeptide binding]; other site 234267005064 active site 234267005065 metal binding site [ion binding]; metal-binding site 234267005066 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 234267005067 dsRNA binding site [nucleotide binding]; other site 234267005068 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 234267005069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005070 TPR motif; other site 234267005071 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267005072 binding surface 234267005073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267005074 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 234267005075 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005076 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 234267005077 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 234267005078 G4 box; other site 234267005079 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234267005080 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 234267005081 Walker A/P-loop; other site 234267005082 ATP binding site [chemical binding]; other site 234267005083 Q-loop/lid; other site 234267005084 ABC transporter signature motif; other site 234267005085 Walker B; other site 234267005086 D-loop; other site 234267005087 H-loop/switch region; other site 234267005088 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267005089 Predicted nucleotidyltransferases [General function prediction only]; Region: COG1708 234267005090 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 234267005091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234267005092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267005093 ABC transporter signature motif; other site 234267005094 Walker B; other site 234267005095 D-loop; other site 234267005096 H-loop/switch region; other site 234267005097 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 234267005098 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005099 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267005100 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 234267005101 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 234267005102 active site 234267005103 Zn binding site [ion binding]; other site 234267005104 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 234267005105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267005106 D-galactonate transporter; Region: 2A0114; TIGR00893 234267005107 putative substrate translocation pore; other site 234267005108 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267005109 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 234267005110 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267005111 Peptidase S46; Region: Peptidase_S46; pfam10459 234267005112 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267005113 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005114 FtsX-like permease family; Region: FtsX; pfam02687 234267005115 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005116 FtsX-like permease family; Region: FtsX; pfam02687 234267005117 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267005118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267005119 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 234267005120 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005121 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005122 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267005123 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267005124 metal binding site [ion binding]; metal-binding site 234267005125 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 234267005126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005127 FtsX-like permease family; Region: FtsX; pfam02687 234267005128 FtsX-like permease family; Region: FtsX; pfam02687 234267005129 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267005130 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267005131 Walker A/P-loop; other site 234267005132 ATP binding site [chemical binding]; other site 234267005133 Q-loop/lid; other site 234267005134 ABC transporter signature motif; other site 234267005135 Walker B; other site 234267005136 D-loop; other site 234267005137 H-loop/switch region; other site 234267005138 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 234267005139 active site 234267005140 catalytic triad [active] 234267005141 oxyanion hole [active] 234267005142 switch loop; other site 234267005143 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234267005144 transaminase; Validated; Region: PRK07324 234267005145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267005146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267005147 homodimer interface [polypeptide binding]; other site 234267005148 catalytic residue [active] 234267005149 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 234267005150 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 234267005151 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 234267005152 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 234267005153 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 234267005154 active site 234267005155 Riboflavin kinase; Region: Flavokinase; pfam01687 234267005156 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 234267005157 putative hydrolase; Provisional; Region: PRK02113 234267005158 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 234267005159 prolyl-tRNA synthetase; Provisional; Region: PRK08661 234267005160 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 234267005161 dimer interface [polypeptide binding]; other site 234267005162 motif 1; other site 234267005163 active site 234267005164 motif 2; other site 234267005165 motif 3; other site 234267005166 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 234267005167 anticodon binding site; other site 234267005168 zinc-binding site [ion binding]; other site 234267005169 DinB superfamily; Region: DinB_2; pfam12867 234267005170 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234267005171 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 234267005172 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 234267005173 homodimer interface [polypeptide binding]; other site 234267005174 metal binding site [ion binding]; metal-binding site 234267005175 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 234267005176 homodimer interface [polypeptide binding]; other site 234267005177 active site 234267005178 putative chemical substrate binding site [chemical binding]; other site 234267005179 metal binding site [ion binding]; metal-binding site 234267005180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267005181 Coenzyme A binding pocket [chemical binding]; other site 234267005182 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 234267005183 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 234267005184 active site 234267005185 octamer interface [polypeptide binding]; other site 234267005186 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267005187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267005188 putative substrate translocation pore; other site 234267005189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234267005190 classical (c) SDRs; Region: SDR_c; cd05233 234267005191 NAD(P) binding site [chemical binding]; other site 234267005192 active site 234267005193 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267005194 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 234267005195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267005196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267005197 dimer interface [polypeptide binding]; other site 234267005198 phosphorylation site [posttranslational modification] 234267005199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005200 ATP binding site [chemical binding]; other site 234267005201 Mg2+ binding site [ion binding]; other site 234267005202 G-X-G motif; other site 234267005203 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267005204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005205 active site 234267005206 phosphorylation site [posttranslational modification] 234267005207 intermolecular recognition site; other site 234267005208 dimerization interface [polypeptide binding]; other site 234267005209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267005210 Walker A motif; other site 234267005211 ATP binding site [chemical binding]; other site 234267005212 Walker B motif; other site 234267005213 arginine finger; other site 234267005214 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267005215 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 234267005216 TH1 protein; Region: TH1; pfam04858 234267005217 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267005218 active site 234267005219 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234267005220 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267005221 phosphopeptide binding site; other site 234267005222 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267005223 GAF domain; Region: GAF_3; pfam13492 234267005224 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267005225 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267005226 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 234267005227 metal binding site 2 [ion binding]; metal-binding site 234267005228 putative DNA binding helix; other site 234267005229 metal binding site 1 [ion binding]; metal-binding site 234267005230 dimer interface [polypeptide binding]; other site 234267005231 structural Zn2+ binding site [ion binding]; other site 234267005232 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 234267005233 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234267005234 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234267005235 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234267005236 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 234267005237 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267005238 carboxyltransferase (CT) interaction site; other site 234267005239 biotinylation site [posttranslational modification]; other site 234267005240 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 234267005241 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 234267005242 homotrimer interaction site [polypeptide binding]; other site 234267005243 zinc binding site [ion binding]; other site 234267005244 CDP-binding sites; other site 234267005245 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 234267005246 substrate binding site; other site 234267005247 dimer interface; other site 234267005248 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 234267005249 putative active site [active] 234267005250 TRAM domain; Region: TRAM; cl01282 234267005251 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267005252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267005253 PAS domain; Region: PAS_9; pfam13426 234267005254 putative active site [active] 234267005255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267005256 PAS fold; Region: PAS_3; pfam08447 234267005257 putative active site [active] 234267005258 heme pocket [chemical binding]; other site 234267005259 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267005260 GAF domain; Region: GAF; pfam01590 234267005261 PAS domain S-box; Region: sensory_box; TIGR00229 234267005262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267005263 putative active site [active] 234267005264 heme pocket [chemical binding]; other site 234267005265 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267005266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267005267 putative active site [active] 234267005268 heme pocket [chemical binding]; other site 234267005269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267005270 putative active site [active] 234267005271 heme pocket [chemical binding]; other site 234267005272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005273 ATP binding site [chemical binding]; other site 234267005274 Mg2+ binding site [ion binding]; other site 234267005275 G-X-G motif; other site 234267005276 Response regulator receiver domain; Region: Response_reg; pfam00072 234267005277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005278 active site 234267005279 phosphorylation site [posttranslational modification] 234267005280 intermolecular recognition site; other site 234267005281 dimerization interface [polypeptide binding]; other site 234267005282 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267005283 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 234267005284 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234267005285 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267005286 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 234267005287 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 234267005288 dimer interface [polypeptide binding]; other site 234267005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267005290 catalytic residue [active] 234267005291 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 234267005292 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 234267005293 TPP-binding site [chemical binding]; other site 234267005294 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 234267005295 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 234267005296 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 234267005297 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 234267005298 dimer interface [polypeptide binding]; other site 234267005299 PYR/PP interface [polypeptide binding]; other site 234267005300 TPP binding site [chemical binding]; other site 234267005301 substrate binding site [chemical binding]; other site 234267005302 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 234267005303 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267005304 DinB superfamily; Region: DinB_2; pfam12867 234267005305 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267005306 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 234267005307 putative hydrophobic ligand binding site [chemical binding]; other site 234267005308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267005309 dimerization interface [polypeptide binding]; other site 234267005310 putative DNA binding site [nucleotide binding]; other site 234267005311 putative Zn2+ binding site [ion binding]; other site 234267005312 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 234267005313 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267005314 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267005315 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005316 FtsX-like permease family; Region: FtsX; pfam02687 234267005317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005318 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267005319 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267005320 Walker A/P-loop; other site 234267005321 ATP binding site [chemical binding]; other site 234267005322 Q-loop/lid; other site 234267005323 ABC transporter signature motif; other site 234267005324 Walker B; other site 234267005325 D-loop; other site 234267005326 H-loop/switch region; other site 234267005327 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234267005328 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 234267005329 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 234267005330 PEP-CTERM motif; Region: VPEP; pfam07589 234267005331 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267005332 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267005333 active site pocket [active] 234267005334 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267005335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267005336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267005337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267005338 Walker A/P-loop; other site 234267005339 ATP binding site [chemical binding]; other site 234267005340 Q-loop/lid; other site 234267005341 ABC transporter signature motif; other site 234267005342 Walker B; other site 234267005343 D-loop; other site 234267005344 H-loop/switch region; other site 234267005345 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 234267005346 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 234267005347 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 234267005348 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 234267005349 catalytic triad [active] 234267005350 conserved cis-peptide bond; other site 234267005351 Erythromycin esterase; Region: Erythro_esteras; pfam05139 234267005352 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267005353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267005354 dimerization interface [polypeptide binding]; other site 234267005355 putative DNA binding site [nucleotide binding]; other site 234267005356 putative Zn2+ binding site [ion binding]; other site 234267005357 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 234267005358 putative hydrophobic ligand binding site [chemical binding]; other site 234267005359 HEAT repeats; Region: HEAT_2; pfam13646 234267005360 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 234267005361 HEAT repeats; Region: HEAT_2; pfam13646 234267005362 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267005363 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 234267005364 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 234267005365 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234267005366 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 234267005367 AAA domain; Region: AAA_30; pfam13604 234267005368 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 234267005369 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 234267005370 Part of AAA domain; Region: AAA_19; pfam13245 234267005371 Family description; Region: UvrD_C_2; pfam13538 234267005372 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 234267005373 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 234267005374 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 234267005375 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 234267005376 dimerization interface [polypeptide binding]; other site 234267005377 active site 234267005378 Uncharacterized conserved protein [Function unknown]; Region: COG1624 234267005379 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 234267005380 YbbR-like protein; Region: YbbR; pfam07949 234267005381 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 234267005382 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 234267005383 active site 234267005384 substrate binding site [chemical binding]; other site 234267005385 metal binding site [ion binding]; metal-binding site 234267005386 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 234267005387 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 234267005388 putative active site [active] 234267005389 Zn binding site [ion binding]; other site 234267005390 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 234267005391 putative active site [active] 234267005392 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234267005393 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 234267005394 dimer interface [polypeptide binding]; other site 234267005395 active site 234267005396 ribosomal protein S1; Region: rpsA; TIGR00717 234267005397 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 234267005398 RNA binding site [nucleotide binding]; other site 234267005399 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 234267005400 RNA binding site [nucleotide binding]; other site 234267005401 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 234267005402 RNA binding site [nucleotide binding]; other site 234267005403 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267005404 RNA binding site [nucleotide binding]; other site 234267005405 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267005406 RNA binding site [nucleotide binding]; other site 234267005407 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267005408 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005409 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267005410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267005411 dimerization interface [polypeptide binding]; other site 234267005412 putative DNA binding site [nucleotide binding]; other site 234267005413 putative Zn2+ binding site [ion binding]; other site 234267005414 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 234267005415 putative hydrophobic ligand binding site [chemical binding]; other site 234267005416 PIN domain; Region: PIN_3; cl17397 234267005417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267005418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267005419 phosphorylation site [posttranslational modification] 234267005420 dimer interface [polypeptide binding]; other site 234267005421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005422 ATP binding site [chemical binding]; other site 234267005423 G-X-G motif; other site 234267005424 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267005425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005426 active site 234267005427 phosphorylation site [posttranslational modification] 234267005428 intermolecular recognition site; other site 234267005429 dimerization interface [polypeptide binding]; other site 234267005430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267005431 Walker A motif; other site 234267005432 ATP binding site [chemical binding]; other site 234267005433 Walker B motif; other site 234267005434 arginine finger; other site 234267005435 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267005436 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 234267005437 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 234267005438 active site 234267005439 dimer interface [polypeptide binding]; other site 234267005440 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 234267005441 dimer interface [polypeptide binding]; other site 234267005442 active site 234267005443 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 234267005444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267005445 Walker A/P-loop; other site 234267005446 ATP binding site [chemical binding]; other site 234267005447 Q-loop/lid; other site 234267005448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267005449 ABC transporter signature motif; other site 234267005450 Walker B; other site 234267005451 D-loop; other site 234267005452 ABC transporter; Region: ABC_tran_2; pfam12848 234267005453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267005454 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 234267005455 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 234267005456 NAD binding site [chemical binding]; other site 234267005457 sugar binding site [chemical binding]; other site 234267005458 divalent metal binding site [ion binding]; other site 234267005459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234267005460 dimer interface [polypeptide binding]; other site 234267005461 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267005462 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 234267005463 substrate binding site [chemical binding]; other site 234267005464 ATP binding site [chemical binding]; other site 234267005465 amino acid transporter; Region: 2A0306; TIGR00909 234267005466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005467 binding surface 234267005468 TPR motif; other site 234267005469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267005470 binding surface 234267005471 TPR motif; other site 234267005472 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267005473 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005474 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005475 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267005476 Family description; Region: VCBS; pfam13517 234267005477 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267005478 Trp docking motif [polypeptide binding]; other site 234267005479 putative active site [active] 234267005480 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267005481 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267005482 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267005483 Family description; Region: VCBS; pfam13517 234267005484 Family description; Region: VCBS; pfam13517 234267005485 Family description; Region: VCBS; pfam13517 234267005486 Family description; Region: VCBS; pfam13517 234267005487 Family description; Region: VCBS; pfam13517 234267005488 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005489 Cupin domain; Region: Cupin_2; pfam07883 234267005490 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 234267005491 TPP-binding site [chemical binding]; other site 234267005492 dimer interface [polypeptide binding]; other site 234267005493 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 234267005494 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 234267005495 PYR/PP interface [polypeptide binding]; other site 234267005496 dimer interface [polypeptide binding]; other site 234267005497 TPP binding site [chemical binding]; other site 234267005498 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267005499 Uncharacterized conserved protein [Function unknown]; Region: COG2006 234267005500 Domain of unknown function (DUF362); Region: DUF362; pfam04015 234267005501 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005502 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267005503 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267005504 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 234267005505 heme-binding residues [chemical binding]; other site 234267005506 TPR repeat; Region: TPR_11; pfam13414 234267005507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005508 binding surface 234267005509 TPR motif; other site 234267005510 TPR repeat; Region: TPR_11; pfam13414 234267005511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005512 TPR motif; other site 234267005513 binding surface 234267005514 TPR repeat; Region: TPR_11; pfam13414 234267005515 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267005516 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234267005517 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234267005518 Bacterial transcriptional regulator; Region: IclR; pfam01614 234267005519 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267005520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267005521 NAD(P) binding site [chemical binding]; other site 234267005522 active site 234267005523 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267005524 Winged helix-turn helix; Region: HTH_29; pfam13551 234267005525 Homeodomain-like domain; Region: HTH_32; pfam13565 234267005526 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005527 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267005528 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267005529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267005530 TPR motif; other site 234267005531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267005532 binding surface 234267005533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005534 binding surface 234267005535 TPR motif; other site 234267005536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267005537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267005538 Tetratricopeptide repeat; Region: TPR_10; pfam13374 234267005539 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267005540 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267005541 Trp docking motif [polypeptide binding]; other site 234267005542 PQQ-like domain; Region: PQQ_2; pfam13360 234267005543 putative active site [active] 234267005544 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267005545 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267005546 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267005547 Family description; Region: VCBS; pfam13517 234267005548 Family description; Region: VCBS; pfam13517 234267005549 Family description; Region: VCBS; pfam13517 234267005550 Family description; Region: VCBS; pfam13517 234267005551 Family description; Region: VCBS; pfam13517 234267005552 hypothetical protein; Provisional; Region: PRK09133 234267005553 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234267005554 putative metal binding site [ion binding]; other site 234267005555 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267005556 Asp-box motif; other site 234267005557 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 234267005558 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005559 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267005560 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267005561 Asp-box motif; other site 234267005562 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267005563 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267005564 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267005565 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267005566 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267005567 Amidohydrolase; Region: Amidohydro_5; pfam13594 234267005568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267005569 Winged helix-turn helix; Region: HTH_29; pfam13551 234267005570 Homeodomain-like domain; Region: HTH_32; pfam13565 234267005571 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 234267005572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005573 binding surface 234267005574 TPR motif; other site 234267005575 Family description; Region: VCBS; pfam13517 234267005576 Family description; Region: VCBS; pfam13517 234267005577 Family description; Region: VCBS; pfam13517 234267005578 Family description; Region: VCBS; pfam13517 234267005579 Family description; Region: VCBS; pfam13517 234267005580 Family description; Region: VCBS; pfam13517 234267005581 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267005582 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 234267005583 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 234267005584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267005585 Cu(I) binding site [ion binding]; other site 234267005586 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 234267005587 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 234267005588 Family description; Region: VCBS; pfam13517 234267005589 Family description; Region: VCBS; pfam13517 234267005590 Family description; Region: VCBS; pfam13517 234267005591 Family description; Region: VCBS; pfam13517 234267005592 Family description; Region: VCBS; pfam13517 234267005593 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267005594 TPR repeat; Region: TPR_11; pfam13414 234267005595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005596 binding surface 234267005597 TPR motif; other site 234267005598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005599 binding surface 234267005600 TPR repeat; Region: TPR_11; pfam13414 234267005601 TPR motif; other site 234267005602 TPR repeat; Region: TPR_11; pfam13414 234267005603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005604 binding surface 234267005605 TPR motif; other site 234267005606 TPR repeat; Region: TPR_11; pfam13414 234267005607 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005608 VPS10 domain; Region: VPS10; smart00602 234267005609 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005610 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267005611 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267005612 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267005613 active site 234267005614 Nidogen-like; Region: NIDO; cl02648 234267005615 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234267005616 FMN binding site [chemical binding]; other site 234267005617 substrate binding site [chemical binding]; other site 234267005618 putative catalytic residue [active] 234267005619 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 234267005620 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234267005621 phosphate binding site [ion binding]; other site 234267005622 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 234267005623 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234267005624 active site 234267005625 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234267005626 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 234267005627 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 234267005628 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 234267005629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267005630 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 234267005631 putative NADP binding site [chemical binding]; other site 234267005632 active site 234267005633 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 234267005634 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 234267005635 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 234267005636 active site 234267005637 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234267005638 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234267005639 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 234267005640 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 234267005641 Phosphopantetheine attachment site; Region: PP-binding; cl09936 234267005642 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267005643 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267005644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267005645 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234267005646 short chain dehydrogenase; Provisional; Region: PRK07832 234267005647 classical (c) SDRs; Region: SDR_c; cd05233 234267005648 NAD(P) binding site [chemical binding]; other site 234267005649 active site 234267005650 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267005651 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 234267005652 putative NAD(P) binding site [chemical binding]; other site 234267005653 active site 234267005654 short chain dehydrogenase; Provisional; Region: PRK06914 234267005655 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 234267005656 NADP binding site [chemical binding]; other site 234267005657 active site 234267005658 steroid binding site; other site 234267005659 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267005660 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267005661 active site 234267005662 TDP-binding site; other site 234267005663 acceptor substrate-binding pocket; other site 234267005664 homodimer interface [polypeptide binding]; other site 234267005665 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267005666 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267005667 active site 234267005668 TDP-binding site; other site 234267005669 acceptor substrate-binding pocket; other site 234267005670 homodimer interface [polypeptide binding]; other site 234267005671 translocation protein TolB; Provisional; Region: tolB; PRK05137 234267005672 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267005673 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 234267005674 Interdomain contacts; other site 234267005675 Cytokine receptor motif; other site 234267005676 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267005677 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267005678 homodimer interface [polypeptide binding]; other site 234267005679 active site 234267005680 TDP-binding site; other site 234267005681 acceptor substrate-binding pocket; other site 234267005682 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267005683 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267005684 homodimer interface [polypeptide binding]; other site 234267005685 active site 234267005686 TDP-binding site; other site 234267005687 acceptor substrate-binding pocket; other site 234267005688 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 234267005689 MFS/sugar transport protein; Region: MFS_2; pfam13347 234267005690 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267005691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267005692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267005693 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267005694 Family description; Region: VCBS; pfam13517 234267005695 Family description; Region: VCBS; pfam13517 234267005696 Family description; Region: VCBS; pfam13517 234267005697 Family description; Region: VCBS; pfam13517 234267005698 Family description; Region: VCBS; pfam13517 234267005699 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267005700 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005701 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005702 TPR repeat; Region: TPR_11; pfam13414 234267005703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005704 binding surface 234267005705 TPR motif; other site 234267005706 TPR repeat; Region: TPR_11; pfam13414 234267005707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005708 binding surface 234267005709 TPR motif; other site 234267005710 TPR repeat; Region: TPR_11; pfam13414 234267005711 TPR repeat; Region: TPR_11; pfam13414 234267005712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005713 binding surface 234267005714 TPR motif; other site 234267005715 TPR repeat; Region: TPR_11; pfam13414 234267005716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005717 binding surface 234267005718 TPR motif; other site 234267005719 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267005720 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267005721 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 234267005722 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234267005723 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 234267005724 substrate binding site [chemical binding]; other site 234267005725 hypothetical protein; Validated; Region: PRK08116 234267005726 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 234267005727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267005728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267005729 active site 234267005730 catalytic tetrad [active] 234267005731 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 234267005732 Protein of unknown function (DUF419); Region: DUF419; pfam04237 234267005733 TPR repeat; Region: TPR_11; pfam13414 234267005734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005735 binding surface 234267005736 TPR motif; other site 234267005737 TPR repeat; Region: TPR_11; pfam13414 234267005738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267005739 TPR motif; other site 234267005740 binding surface 234267005741 TPR repeat; Region: TPR_11; pfam13414 234267005742 TPR repeat; Region: TPR_11; pfam13414 234267005743 Transglycosylase; Region: Transgly; pfam00912 234267005744 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 234267005745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267005746 Proline dehydrogenase; Region: Pro_dh; cl03282 234267005747 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 234267005748 Leucine-rich repeats; other site 234267005749 Substrate binding site [chemical binding]; other site 234267005750 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005751 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267005752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005753 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267005754 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267005755 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267005756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 234267005757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234267005758 catalytic residue [active] 234267005759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267005760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267005761 Predicted acyl esterases [General function prediction only]; Region: COG2936 234267005762 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 234267005763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267005764 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 234267005765 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 234267005766 putative active site [active] 234267005767 putative NTP binding site [chemical binding]; other site 234267005768 putative nucleic acid binding site [nucleotide binding]; other site 234267005769 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267005770 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267005771 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 234267005772 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 234267005773 GDP-binding site [chemical binding]; other site 234267005774 ACT binding site; other site 234267005775 IMP binding site; other site 234267005776 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267005777 Protein of unknown function DUF72; Region: DUF72; pfam01904 234267005778 trigger factor; Region: tig; TIGR00115 234267005779 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234267005780 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 234267005781 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 234267005782 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 234267005783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267005784 Walker A motif; other site 234267005785 ATP binding site [chemical binding]; other site 234267005786 Walker B motif; other site 234267005787 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234267005788 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 234267005789 Found in ATP-dependent protease La (LON); Region: LON; smart00464 234267005790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267005791 Walker A motif; other site 234267005792 ATP binding site [chemical binding]; other site 234267005793 Walker B motif; other site 234267005794 arginine finger; other site 234267005795 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 234267005796 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 234267005797 G1 box; other site 234267005798 GTP/Mg2+ binding site [chemical binding]; other site 234267005799 Switch I region; other site 234267005800 G2 box; other site 234267005801 G3 box; other site 234267005802 Switch II region; other site 234267005803 G4 box; other site 234267005804 G5 box; other site 234267005805 transcription termination factor Rho; Provisional; Region: rho; PRK09376 234267005806 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 234267005807 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 234267005808 RNA binding site [nucleotide binding]; other site 234267005809 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 234267005810 multimer interface [polypeptide binding]; other site 234267005811 Walker A motif; other site 234267005812 ATP binding site [chemical binding]; other site 234267005813 Walker B motif; other site 234267005814 putative aminotransferase; Provisional; Region: PRK09105 234267005815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267005816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267005817 homodimer interface [polypeptide binding]; other site 234267005818 catalytic residue [active] 234267005819 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267005820 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267005821 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267005822 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267005823 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267005824 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267005825 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267005826 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267005827 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267005828 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267005829 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267005830 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267005831 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267005832 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267005833 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267005834 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234267005835 HSP70 interaction site [polypeptide binding]; other site 234267005836 VPS10 domain; Region: VPS10; smart00602 234267005837 VPS10 domain; Region: VPS10; smart00602 234267005838 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234267005839 FAD binding domain; Region: FAD_binding_4; pfam01565 234267005840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005841 ATP binding site [chemical binding]; other site 234267005842 Mg2+ binding site [ion binding]; other site 234267005843 G-X-G motif; other site 234267005844 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267005845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005846 active site 234267005847 phosphorylation site [posttranslational modification] 234267005848 intermolecular recognition site; other site 234267005849 dimerization interface [polypeptide binding]; other site 234267005850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267005851 Walker A motif; other site 234267005852 ATP binding site [chemical binding]; other site 234267005853 Walker B motif; other site 234267005854 arginine finger; other site 234267005855 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267005856 Response regulator receiver domain; Region: Response_reg; pfam00072 234267005857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005858 active site 234267005859 phosphorylation site [posttranslational modification] 234267005860 intermolecular recognition site; other site 234267005861 dimerization interface [polypeptide binding]; other site 234267005862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005863 ATP binding site [chemical binding]; other site 234267005864 Mg2+ binding site [ion binding]; other site 234267005865 G-X-G motif; other site 234267005866 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267005867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005868 active site 234267005869 phosphorylation site [posttranslational modification] 234267005870 intermolecular recognition site; other site 234267005871 dimerization interface [polypeptide binding]; other site 234267005872 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267005873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267005874 putative active site [active] 234267005875 heme pocket [chemical binding]; other site 234267005876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 234267005877 phosphorylation site [posttranslational modification] 234267005878 dimer interface [polypeptide binding]; other site 234267005879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005880 ATP binding site [chemical binding]; other site 234267005881 Mg2+ binding site [ion binding]; other site 234267005882 G-X-G motif; other site 234267005883 Response regulator receiver domain; Region: Response_reg; pfam00072 234267005884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005885 active site 234267005886 phosphorylation site [posttranslational modification] 234267005887 intermolecular recognition site; other site 234267005888 dimerization interface [polypeptide binding]; other site 234267005889 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 234267005890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005891 dimerization interface [polypeptide binding]; other site 234267005892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005893 dimerization interface [polypeptide binding]; other site 234267005894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005895 dimerization interface [polypeptide binding]; other site 234267005896 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 234267005897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005898 dimerization interface [polypeptide binding]; other site 234267005899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005900 dimerization interface [polypeptide binding]; other site 234267005901 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 234267005902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005903 dimerization interface [polypeptide binding]; other site 234267005904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005905 dimerization interface [polypeptide binding]; other site 234267005906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005907 dimerization interface [polypeptide binding]; other site 234267005908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005909 dimerization interface [polypeptide binding]; other site 234267005910 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 234267005911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005912 dimerization interface [polypeptide binding]; other site 234267005913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005914 dimerization interface [polypeptide binding]; other site 234267005915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267005916 dimerization interface [polypeptide binding]; other site 234267005917 HAMP domain; Region: HAMP; pfam00672 234267005918 dimerization interface [polypeptide binding]; other site 234267005919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 234267005920 dimerization interface [polypeptide binding]; other site 234267005921 GAF domain; Region: GAF_2; pfam13185 234267005922 GAF domain; Region: GAF; cl17456 234267005923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267005924 dimer interface [polypeptide binding]; other site 234267005925 phosphorylation site [posttranslational modification] 234267005926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005927 ATP binding site [chemical binding]; other site 234267005928 Mg2+ binding site [ion binding]; other site 234267005929 G-X-G motif; other site 234267005930 Response regulator receiver domain; Region: Response_reg; pfam00072 234267005931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005932 active site 234267005933 phosphorylation site [posttranslational modification] 234267005934 intermolecular recognition site; other site 234267005935 dimerization interface [polypeptide binding]; other site 234267005936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 234267005937 active site 234267005938 phosphorylation site [posttranslational modification] 234267005939 intermolecular recognition site; other site 234267005940 Response regulator receiver domain; Region: Response_reg; pfam00072 234267005941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005942 active site 234267005943 phosphorylation site [posttranslational modification] 234267005944 intermolecular recognition site; other site 234267005945 dimerization interface [polypeptide binding]; other site 234267005946 Response regulator receiver domain; Region: Response_reg; pfam00072 234267005947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267005948 active site 234267005949 phosphorylation site [posttranslational modification] 234267005950 intermolecular recognition site; other site 234267005951 dimerization interface [polypeptide binding]; other site 234267005952 PAS domain; Region: PAS; smart00091 234267005953 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267005954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267005955 dimer interface [polypeptide binding]; other site 234267005956 phosphorylation site [posttranslational modification] 234267005957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267005958 ATP binding site [chemical binding]; other site 234267005959 Mg2+ binding site [ion binding]; other site 234267005960 G-X-G motif; other site 234267005961 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267005962 Cytochrome c; Region: Cytochrom_C; pfam00034 234267005963 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267005964 Trehalose utilisation; Region: ThuA; pfam06283 234267005965 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267005966 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 234267005967 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 234267005968 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267005969 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267005970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267005971 Walker A motif; other site 234267005972 ATP binding site [chemical binding]; other site 234267005973 Walker B motif; other site 234267005974 arginine finger; other site 234267005975 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267005976 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 234267005977 RNA polymerase sigma factor; Provisional; Region: PRK11922 234267005978 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267005979 anti sigma factor interaction site; other site 234267005980 regulatory phosphorylation site [posttranslational modification]; other site 234267005981 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267005982 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 234267005983 putative active site pocket [active] 234267005984 putative metal binding site [ion binding]; other site 234267005985 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234267005986 FAD binding domain; Region: FAD_binding_4; pfam01565 234267005987 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 234267005988 Cysteine-rich domain; Region: CCG; pfam02754 234267005989 Cysteine-rich domain; Region: CCG; pfam02754 234267005990 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 234267005991 trimer interface [polypeptide binding]; other site 234267005992 putative Zn binding site [ion binding]; other site 234267005993 short chain dehydrogenase; Provisional; Region: PRK07109 234267005994 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 234267005995 putative NAD(P) binding site [chemical binding]; other site 234267005996 active site 234267005997 HipA N-terminal domain; Region: Couple_hipA; pfam13657 234267005998 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 234267005999 HipA-like N-terminal domain; Region: HipA_N; pfam07805 234267006000 HipA-like C-terminal domain; Region: HipA_C; pfam07804 234267006001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267006002 non-specific DNA binding site [nucleotide binding]; other site 234267006003 salt bridge; other site 234267006004 sequence-specific DNA binding site [nucleotide binding]; other site 234267006005 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267006006 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267006007 Trp docking motif [polypeptide binding]; other site 234267006008 active site 234267006009 Cytochrome c; Region: Cytochrom_C; pfam00034 234267006010 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267006011 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267006012 Metal-binding active site; metal-binding site 234267006013 BNR repeat-like domain; Region: BNR_2; pfam13088 234267006014 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234267006016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267006017 DNA-binding site [nucleotide binding]; DNA binding site 234267006018 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267006019 dimerization interface [polypeptide binding]; other site 234267006020 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 234267006021 ligand binding site [chemical binding]; other site 234267006022 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267006023 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 234267006024 putative substrate binding site [chemical binding]; other site 234267006025 putative ATP binding site [chemical binding]; other site 234267006026 sucrose phosphorylase; Provisional; Region: PRK13840 234267006027 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 234267006028 active site 234267006029 homodimer interface [polypeptide binding]; other site 234267006030 catalytic site [active] 234267006031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006032 putative substrate translocation pore; other site 234267006033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267006034 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 234267006035 active site 234267006036 catalytic triad [active] 234267006037 oxyanion hole [active] 234267006038 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 234267006039 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267006040 Putative esterase; Region: Esterase; pfam00756 234267006041 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 234267006042 active site 234267006043 catalytic triad [active] 234267006044 oxyanion hole [active] 234267006045 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 234267006046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006047 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 234267006048 putative substrate translocation pore; other site 234267006049 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234267006050 Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like; Region: ALDH_LactADH_F420-Bios; cd07145 234267006051 NAD(P) binding site [chemical binding]; other site 234267006052 catalytic residues [active] 234267006053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267006054 DNA-binding site [nucleotide binding]; DNA binding site 234267006055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267006056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267006057 ligand binding site [chemical binding]; other site 234267006058 dimerization interface [polypeptide binding]; other site 234267006059 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 234267006060 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 234267006061 substrate binding [chemical binding]; other site 234267006062 active site 234267006063 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 234267006064 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 234267006065 dimerization interface [polypeptide binding]; other site 234267006066 putative active cleft [active] 234267006067 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267006068 BNR repeat-like domain; Region: BNR_2; pfam13088 234267006069 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006070 Carboxylesterase family; Region: COesterase; pfam00135 234267006071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267006072 substrate binding pocket [chemical binding]; other site 234267006073 catalytic triad [active] 234267006074 Carboxylesterase family; Region: COesterase; pfam00135 234267006075 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267006076 substrate binding pocket [chemical binding]; other site 234267006077 catalytic triad [active] 234267006078 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267006079 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267006080 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267006081 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 234267006082 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267006083 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 234267006084 active site 234267006085 catalytic triad [active] 234267006086 oxyanion hole [active] 234267006087 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 234267006088 active site 234267006089 catalytic triad [active] 234267006090 oxyanion hole [active] 234267006091 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006092 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 234267006093 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267006094 substrate binding pocket [chemical binding]; other site 234267006095 catalytic triad [active] 234267006096 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006097 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267006098 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 234267006099 Family description; Region: VCBS; pfam13517 234267006100 Family description; Region: VCBS; pfam13517 234267006101 Family description; Region: VCBS; pfam13517 234267006102 Family description; Region: VCBS; pfam13517 234267006103 Family description; Region: VCBS; pfam13517 234267006104 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267006105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006106 TPR motif; other site 234267006107 TPR repeat; Region: TPR_11; pfam13414 234267006108 binding surface 234267006109 TPR repeat; Region: TPR_11; pfam13414 234267006110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006111 TPR motif; other site 234267006112 binding surface 234267006113 TPR repeat; Region: TPR_11; pfam13414 234267006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006115 binding surface 234267006116 TPR motif; other site 234267006117 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267006118 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267006119 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267006120 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267006121 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267006122 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267006123 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 234267006124 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267006125 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 234267006126 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 234267006127 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 234267006128 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 234267006129 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267006130 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 234267006131 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 234267006132 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267006133 Domain of unknown function (DUF303); Region: DUF303; pfam03629 234267006134 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267006135 Domain of unknown function (DUF303); Region: DUF303; pfam03629 234267006136 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 234267006137 Carboxylesterase family; Region: COesterase; pfam00135 234267006138 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267006139 substrate binding pocket [chemical binding]; other site 234267006140 catalytic triad [active] 234267006141 Family description; Region: VCBS; pfam13517 234267006142 Family description; Region: VCBS; pfam13517 234267006143 Family description; Region: VCBS; pfam13517 234267006144 Family description; Region: VCBS; pfam13517 234267006145 Family description; Region: VCBS; pfam13517 234267006146 Family description; Region: VCBS; pfam13517 234267006147 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267006148 TPR repeat; Region: TPR_11; pfam13414 234267006149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006150 TPR motif; other site 234267006151 binding surface 234267006152 TPR repeat; Region: TPR_11; pfam13414 234267006153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006154 TPR motif; other site 234267006155 binding surface 234267006156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006157 TPR motif; other site 234267006158 TPR repeat; Region: TPR_11; pfam13414 234267006159 binding surface 234267006160 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006161 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267006162 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267006163 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267006164 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267006165 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267006166 Trp docking motif [polypeptide binding]; other site 234267006167 active site 234267006168 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267006169 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267006170 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 234267006171 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 234267006172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267006173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267006174 sequence-specific DNA binding site [nucleotide binding]; other site 234267006175 salt bridge; other site 234267006176 Cupin domain; Region: Cupin_2; pfam07883 234267006177 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 234267006178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006179 D-galactonate transporter; Region: 2A0114; TIGR00893 234267006180 putative substrate translocation pore; other site 234267006181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267006182 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 234267006183 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 234267006184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267006185 PAS fold; Region: PAS_3; pfam08447 234267006186 putative active site [active] 234267006187 heme pocket [chemical binding]; other site 234267006188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267006189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006190 ATP binding site [chemical binding]; other site 234267006191 Mg2+ binding site [ion binding]; other site 234267006192 G-X-G motif; other site 234267006193 Response regulator receiver domain; Region: Response_reg; pfam00072 234267006194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006195 active site 234267006196 phosphorylation site [posttranslational modification] 234267006197 intermolecular recognition site; other site 234267006198 dimerization interface [polypeptide binding]; other site 234267006199 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 234267006200 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 234267006201 Lamin Tail Domain; Region: LTD; pfam00932 234267006202 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267006203 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267006204 active site 234267006205 ATP binding site [chemical binding]; other site 234267006206 substrate binding site [chemical binding]; other site 234267006207 activation loop (A-loop); other site 234267006208 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267006209 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 234267006210 substrate binding site [chemical binding]; other site 234267006211 ATP binding site [chemical binding]; other site 234267006212 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 234267006213 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 234267006214 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 234267006215 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267006216 Ligand binding site; other site 234267006217 Putative Catalytic site; other site 234267006218 DXD motif; other site 234267006219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267006220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006221 S-adenosylmethionine binding site [chemical binding]; other site 234267006222 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267006223 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 234267006224 intracellular protease, PfpI family; Region: PfpI; TIGR01382 234267006225 conserved cys residue [active] 234267006226 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234267006227 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 234267006228 homodimer interaction site [polypeptide binding]; other site 234267006229 cofactor binding site; other site 234267006230 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267006231 classical (c) SDRs; Region: SDR_c; cd05233 234267006232 NAD(P) binding site [chemical binding]; other site 234267006233 active site 234267006234 Bacterial PH domain; Region: DUF304; pfam03703 234267006235 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234267006236 Peptidase family M23; Region: Peptidase_M23; pfam01551 234267006237 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 234267006238 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234267006239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 234267006240 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234267006241 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 234267006242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 234267006243 dimer interface [polypeptide binding]; other site 234267006244 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 234267006245 putative CheW interface [polypeptide binding]; other site 234267006246 PBP superfamily domain; Region: PBP_like_2; cl17296 234267006247 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 234267006248 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 234267006249 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 234267006250 NAD binding site [chemical binding]; other site 234267006251 ligand binding site [chemical binding]; other site 234267006252 catalytic site [active] 234267006253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006254 S-adenosylmethionine binding site [chemical binding]; other site 234267006255 DinB family; Region: DinB; cl17821 234267006256 DinB superfamily; Region: DinB_2; pfam12867 234267006257 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 234267006258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267006259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267006260 DNA binding residues [nucleotide binding] 234267006261 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267006262 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267006263 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267006264 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267006265 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267006266 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267006267 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267006268 Winged helix-turn helix; Region: HTH_29; pfam13551 234267006269 DNA-binding interface [nucleotide binding]; DNA binding site 234267006270 Homeodomain-like domain; Region: HTH_32; pfam13565 234267006271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267006272 Integrase core domain; Region: rve; pfam00665 234267006273 Integrase core domain; Region: rve_3; pfam13683 234267006274 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267006275 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 234267006276 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 234267006277 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267006278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267006279 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267006280 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267006281 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267006282 active site 234267006283 metal binding site [ion binding]; metal-binding site 234267006284 metal-dependent hydrolase; Provisional; Region: PRK13291 234267006285 DinB superfamily; Region: DinB_2; pfam12867 234267006286 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 234267006287 classical (c) SDRs; Region: SDR_c; cd05233 234267006288 NAD(P) binding site [chemical binding]; other site 234267006289 active site 234267006290 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 234267006291 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 234267006292 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 234267006293 putative substrate binding site [chemical binding]; other site 234267006294 putative ATP binding site [chemical binding]; other site 234267006295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267006296 dimerization interface [polypeptide binding]; other site 234267006297 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267006298 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267006299 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267006300 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 234267006301 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267006302 Ligand binding site; other site 234267006303 Putative Catalytic site; other site 234267006304 DXD motif; other site 234267006305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267006306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006307 active site 234267006308 phosphorylation site [posttranslational modification] 234267006309 intermolecular recognition site; other site 234267006310 dimerization interface [polypeptide binding]; other site 234267006311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267006312 DNA binding site [nucleotide binding] 234267006313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267006314 dimerization interface [polypeptide binding]; other site 234267006315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267006316 dimer interface [polypeptide binding]; other site 234267006317 phosphorylation site [posttranslational modification] 234267006318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006319 ATP binding site [chemical binding]; other site 234267006320 Mg2+ binding site [ion binding]; other site 234267006321 G-X-G motif; other site 234267006322 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234267006323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006324 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267006325 putative substrate translocation pore; other site 234267006326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006327 TPR motif; other site 234267006328 binding surface 234267006329 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 234267006330 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006331 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267006332 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 234267006333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267006334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267006335 DinB family; Region: DinB; cl17821 234267006336 DinB superfamily; Region: DinB_2; pfam12867 234267006337 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267006338 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 234267006339 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 234267006340 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 234267006341 FeoA domain; Region: FeoA; pfam04023 234267006342 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267006343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006344 S-adenosylmethionine binding site [chemical binding]; other site 234267006345 Histidine kinase; Region: His_kinase; pfam06580 234267006346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006347 ATP binding site [chemical binding]; other site 234267006348 Mg2+ binding site [ion binding]; other site 234267006349 G-X-G motif; other site 234267006350 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 234267006351 dimerization interface [polypeptide binding]; other site 234267006352 active site 234267006353 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267006354 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006355 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006356 FtsX-like permease family; Region: FtsX; pfam02687 234267006357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234267006358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267006359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234267006360 dimerization interface [polypeptide binding]; other site 234267006361 NHL repeat; Region: NHL; pfam01436 234267006362 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267006363 diaminopimelate decarboxylase; Region: lysA; TIGR01048 234267006364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 234267006365 active site 234267006366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234267006367 substrate binding site [chemical binding]; other site 234267006368 catalytic residues [active] 234267006369 dimer interface [polypeptide binding]; other site 234267006370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267006371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006372 active site 234267006373 phosphorylation site [posttranslational modification] 234267006374 intermolecular recognition site; other site 234267006375 dimerization interface [polypeptide binding]; other site 234267006376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267006377 DNA binding residues [nucleotide binding] 234267006378 dimerization interface [polypeptide binding]; other site 234267006379 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 234267006380 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 234267006381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234267006382 Histidine kinase; Region: HisKA_3; pfam07730 234267006383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006384 ATP binding site [chemical binding]; other site 234267006385 Mg2+ binding site [ion binding]; other site 234267006386 G-X-G motif; other site 234267006387 HEAT repeats; Region: HEAT_2; pfam13646 234267006388 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 234267006389 RNA polymerase sigma factor; Provisional; Region: PRK12539 234267006390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267006391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267006392 DNA binding residues [nucleotide binding] 234267006393 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267006394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006395 active site 234267006396 phosphorylation site [posttranslational modification] 234267006397 intermolecular recognition site; other site 234267006398 dimerization interface [polypeptide binding]; other site 234267006399 LytTr DNA-binding domain; Region: LytTR; smart00850 234267006400 Histidine kinase; Region: His_kinase; pfam06580 234267006401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006402 ATP binding site [chemical binding]; other site 234267006403 Mg2+ binding site [ion binding]; other site 234267006404 G-X-G motif; other site 234267006405 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267006406 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267006407 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267006408 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267006409 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267006410 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267006411 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267006412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267006413 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267006414 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267006415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006416 putative substrate translocation pore; other site 234267006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 234267006418 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 234267006419 High-affinity nickel-transport protein; Region: NicO; cl00964 234267006420 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 234267006421 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 234267006422 intersubunit interface [polypeptide binding]; other site 234267006423 active site 234267006424 catalytic residue [active] 234267006425 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267006426 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267006427 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267006428 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 234267006429 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267006430 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267006431 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267006432 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 234267006433 Catalytic site [active] 234267006434 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267006435 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 234267006436 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 234267006437 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267006438 metal ion-dependent adhesion site (MIDAS); other site 234267006439 hypothetical protein; Provisional; Region: PRK09133 234267006440 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234267006441 putative metal binding site [ion binding]; other site 234267006442 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 234267006443 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267006444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006445 FtsX-like permease family; Region: FtsX; pfam02687 234267006446 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006447 FtsX-like permease family; Region: FtsX; pfam02687 234267006448 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267006449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267006450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267006451 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 234267006452 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267006453 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267006454 metal ion-dependent adhesion site (MIDAS); other site 234267006455 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267006456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006457 active site 234267006458 phosphorylation site [posttranslational modification] 234267006459 intermolecular recognition site; other site 234267006460 dimerization interface [polypeptide binding]; other site 234267006461 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 234267006462 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 234267006463 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 234267006464 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 234267006465 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267006466 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267006467 NAD(P) binding site [chemical binding]; other site 234267006468 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 234267006469 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 234267006470 NADP binding site [chemical binding]; other site 234267006471 homodimer interface [polypeptide binding]; other site 234267006472 active site 234267006473 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 234267006474 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like3; cd08013 234267006475 metal binding site [ion binding]; metal-binding site 234267006476 putative dimer interface [polypeptide binding]; other site 234267006477 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234267006478 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267006479 catalytic loop [active] 234267006480 iron binding site [ion binding]; other site 234267006481 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267006482 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267006483 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267006484 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267006485 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 234267006486 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 234267006487 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 234267006488 putative hydrophobic ligand binding site [chemical binding]; other site 234267006489 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267006490 Winged helix-turn helix; Region: HTH_29; pfam13551 234267006491 DNA-binding interface [nucleotide binding]; DNA binding site 234267006492 Homeodomain-like domain; Region: HTH_32; pfam13565 234267006493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267006494 Integrase core domain; Region: rve; pfam00665 234267006495 Integrase core domain; Region: rve_3; pfam13683 234267006496 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 234267006497 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 234267006498 putative metal binding site [ion binding]; other site 234267006499 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 234267006500 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267006501 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267006502 AP (apurinic/apyrimidinic) site pocket; other site 234267006503 Metal-binding active site; metal-binding site 234267006504 aspartate aminotransferase; Provisional; Region: PRK06108 234267006505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267006507 homodimer interface [polypeptide binding]; other site 234267006508 catalytic residue [active] 234267006509 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 234267006510 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 234267006511 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 234267006512 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 234267006513 Ligand binding site; other site 234267006514 Putative Catalytic site; other site 234267006515 DXD motif; other site 234267006516 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 234267006517 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 234267006518 dimer interface [polypeptide binding]; other site 234267006519 active site 234267006520 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267006521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006522 S-adenosylmethionine binding site [chemical binding]; other site 234267006523 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 234267006524 flagellin modification protein A; Provisional; Region: PRK09186 234267006525 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 234267006526 putative NAD(P) binding site [chemical binding]; other site 234267006527 active site 234267006528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267006529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267006530 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267006531 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 234267006532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234267006533 PYR/PP interface [polypeptide binding]; other site 234267006534 dimer interface [polypeptide binding]; other site 234267006535 TPP binding site [chemical binding]; other site 234267006536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267006537 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 234267006538 TPP-binding site [chemical binding]; other site 234267006539 Methyltransferase domain; Region: Methyltransf_24; pfam13578 234267006540 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234267006541 NeuB family; Region: NeuB; pfam03102 234267006542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267006543 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267006544 NAD(P) binding site [chemical binding]; other site 234267006545 active site 234267006546 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 234267006547 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234267006548 inhibitor-cofactor binding pocket; inhibition site 234267006549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267006550 catalytic residue [active] 234267006551 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 234267006552 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 234267006553 NAD binding site [chemical binding]; other site 234267006554 homotetramer interface [polypeptide binding]; other site 234267006555 homodimer interface [polypeptide binding]; other site 234267006556 substrate binding site [chemical binding]; other site 234267006557 active site 234267006558 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 234267006559 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 234267006560 substrate binding site; other site 234267006561 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 234267006562 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 234267006563 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267006564 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267006565 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 234267006566 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267006567 active site 234267006568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267006569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267006570 active site 234267006571 catalytic tetrad [active] 234267006572 BMC domain; Region: BMC; pfam00936 234267006573 Hexamer interface [polypeptide binding]; other site 234267006574 Hexagonal pore residue; other site 234267006575 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 234267006576 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 234267006577 Hexamer interface [polypeptide binding]; other site 234267006578 Hexagonal pore residue; other site 234267006579 dihydrodipicolinate synthase; Region: dapA; TIGR00674 234267006580 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267006581 inhibitor site; inhibition site 234267006582 active site 234267006583 dimer interface [polypeptide binding]; other site 234267006584 catalytic residue [active] 234267006585 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267006586 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267006587 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 234267006588 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234267006589 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234267006590 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 234267006591 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267006592 carboxyltransferase (CT) interaction site; other site 234267006593 biotinylation site [posttranslational modification]; other site 234267006594 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267006595 anti sigma factor interaction site; other site 234267006596 regulatory phosphorylation site [posttranslational modification]; other site 234267006597 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267006598 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267006599 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267006600 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 234267006601 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 234267006602 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267006603 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267006604 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267006605 putative transposase OrfB; Reviewed; Region: PHA02517 234267006606 HTH-like domain; Region: HTH_21; pfam13276 234267006607 Integrase core domain; Region: rve; pfam00665 234267006608 Integrase core domain; Region: rve_3; pfam13683 234267006609 Transposase; Region: HTH_Tnp_1; pfam01527 234267006610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267006611 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 234267006612 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 234267006613 dinuclear metal binding motif [ion binding]; other site 234267006614 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 234267006615 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267006616 Walker A/P-loop; other site 234267006617 ATP binding site [chemical binding]; other site 234267006618 Q-loop/lid; other site 234267006619 ABC transporter signature motif; other site 234267006620 Walker B; other site 234267006621 D-loop; other site 234267006622 H-loop/switch region; other site 234267006623 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 234267006624 Clp amino terminal domain; Region: Clp_N; pfam02861 234267006625 Clp amino terminal domain; Region: Clp_N; pfam02861 234267006626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267006627 Walker A motif; other site 234267006628 ATP binding site [chemical binding]; other site 234267006629 Walker B motif; other site 234267006630 arginine finger; other site 234267006631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267006632 Walker A motif; other site 234267006633 ATP binding site [chemical binding]; other site 234267006634 Walker B motif; other site 234267006635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234267006636 SnoaL-like domain; Region: SnoaL_2; pfam12680 234267006637 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234267006638 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234267006639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267006640 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267006641 Amidohydrolase; Region: Amidohydro_4; pfam13147 234267006642 active site 234267006643 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267006644 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267006645 catalytic residues [active] 234267006646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267006647 Tetratricopeptide repeat; Region: TPR_10; pfam13374 234267006648 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 234267006649 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 234267006650 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 234267006651 active site 234267006652 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267006653 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234267006654 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267006655 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267006656 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267006657 Trp docking motif [polypeptide binding]; other site 234267006658 putative active site [active] 234267006659 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267006660 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 234267006661 putative hydrophobic ligand binding site [chemical binding]; other site 234267006662 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267006663 dimerization interface [polypeptide binding]; other site 234267006664 putative DNA binding site [nucleotide binding]; other site 234267006665 putative Zn2+ binding site [ion binding]; other site 234267006666 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267006667 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 234267006668 PAS fold; Region: PAS_3; pfam08447 234267006669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 234267006670 heme pocket [chemical binding]; other site 234267006671 putative active site [active] 234267006672 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267006673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267006674 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267006675 putative active site [active] 234267006676 heme pocket [chemical binding]; other site 234267006677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006678 ATP binding site [chemical binding]; other site 234267006679 Mg2+ binding site [ion binding]; other site 234267006680 G-X-G motif; other site 234267006681 Response regulator receiver domain; Region: Response_reg; pfam00072 234267006682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006683 active site 234267006684 phosphorylation site [posttranslational modification] 234267006685 intermolecular recognition site; other site 234267006686 dimerization interface [polypeptide binding]; other site 234267006687 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 234267006688 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 234267006689 putative metal binding site [ion binding]; other site 234267006690 Amino acid permease; Region: AA_permease_2; pfam13520 234267006691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 234267006692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 234267006693 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 234267006694 Stage II sporulation protein; Region: SpoIID; pfam08486 234267006695 MG2 domain; Region: A2M_N; pfam01835 234267006696 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 234267006697 Alpha-2-macroglobulin family; Region: A2M; pfam00207 234267006698 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 234267006699 surface patch; other site 234267006700 thioester region; other site 234267006701 Protein of unknown function (DUF1175); Region: DUF1175; pfam06672 234267006702 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 234267006703 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 234267006704 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267006705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267006706 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267006707 Walker A motif; other site 234267006708 ATP binding site [chemical binding]; other site 234267006709 Walker B motif; other site 234267006710 arginine finger; other site 234267006711 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267006712 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267006713 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267006714 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006715 FtsX-like permease family; Region: FtsX; pfam02687 234267006716 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006717 FtsX-like permease family; Region: FtsX; pfam02687 234267006718 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267006719 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267006720 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267006722 active site 234267006723 phosphorylation site [posttranslational modification] 234267006724 intermolecular recognition site; other site 234267006725 dimerization interface [polypeptide binding]; other site 234267006726 LytTr DNA-binding domain; Region: LytTR; smart00850 234267006727 Histidine kinase; Region: His_kinase; pfam06580 234267006728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006729 Mg2+ binding site [ion binding]; other site 234267006730 G-X-G motif; other site 234267006731 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 234267006732 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 234267006733 Protein of unknown function, DUF608; Region: DUF608; pfam04685 234267006734 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 234267006735 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267006736 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267006737 conserved cys residue [active] 234267006738 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267006739 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267006740 metal ion-dependent adhesion site (MIDAS); other site 234267006741 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 234267006742 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 234267006743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267006744 catalytic residue [active] 234267006745 PilZ domain; Region: PilZ; pfam07238 234267006746 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 234267006747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267006748 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267006749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267006750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267006751 DNA binding residues [nucleotide binding] 234267006752 Putative zinc-finger; Region: zf-HC2; pfam13490 234267006753 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 234267006754 Double zinc ribbon; Region: DZR; pfam12773 234267006755 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 234267006756 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 234267006757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267006758 non-specific DNA binding site [nucleotide binding]; other site 234267006759 salt bridge; other site 234267006760 sequence-specific DNA binding site [nucleotide binding]; other site 234267006761 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 234267006762 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 234267006763 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 234267006764 putative dimer interface [polypeptide binding]; other site 234267006765 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 234267006766 Clp amino terminal domain; Region: Clp_N; pfam02861 234267006767 Clp amino terminal domain; Region: Clp_N; pfam02861 234267006768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267006769 Walker A motif; other site 234267006770 ATP binding site [chemical binding]; other site 234267006771 Walker B motif; other site 234267006772 arginine finger; other site 234267006773 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 234267006774 linker region; other site 234267006775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267006776 Walker A motif; other site 234267006777 ATP binding site [chemical binding]; other site 234267006778 Walker B motif; other site 234267006779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234267006780 Peptidase family M48; Region: Peptidase_M48; cl12018 234267006781 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 234267006782 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 234267006783 putative RNA binding site [nucleotide binding]; other site 234267006784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006785 S-adenosylmethionine binding site [chemical binding]; other site 234267006786 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234267006787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267006788 NAD(P) binding site [chemical binding]; other site 234267006789 active site 234267006790 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234267006791 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 234267006792 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234267006793 inhibitor-cofactor binding pocket; inhibition site 234267006794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267006795 catalytic residue [active] 234267006796 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 234267006797 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 234267006798 putative trimer interface [polypeptide binding]; other site 234267006799 putative active site [active] 234267006800 putative substrate binding site [chemical binding]; other site 234267006801 putative CoA binding site [chemical binding]; other site 234267006802 WxcM-like, C-terminal; Region: FdtA; pfam05523 234267006803 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 234267006804 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 234267006805 Ligand binding site; other site 234267006806 Putative Catalytic site; other site 234267006807 DXD motif; other site 234267006808 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267006809 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267006810 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006812 S-adenosylmethionine binding site [chemical binding]; other site 234267006813 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 234267006814 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 234267006815 putative trimer interface [polypeptide binding]; other site 234267006816 putative CoA binding site [chemical binding]; other site 234267006817 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 234267006818 putative trimer interface [polypeptide binding]; other site 234267006819 putative CoA binding site [chemical binding]; other site 234267006820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267006821 Protein of unknown function (DUF507); Region: DUF507; pfam04368 234267006822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267006824 putative substrate translocation pore; other site 234267006825 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 234267006826 Fe-S cluster binding site [ion binding]; other site 234267006827 active site 234267006828 Flavoprotein; Region: Flavoprotein; pfam02441 234267006829 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 234267006830 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 234267006831 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 234267006832 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 234267006833 Guanylate kinase; Region: Guanylate_kin; pfam00625 234267006834 catalytic site [active] 234267006835 G-X2-G-X-G-K; other site 234267006836 hypothetical protein; Provisional; Region: PRK11820 234267006837 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 234267006838 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 234267006839 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267006840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267006841 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 234267006842 Walker A/P-loop; other site 234267006843 ATP binding site [chemical binding]; other site 234267006844 Q-loop/lid; other site 234267006845 ABC transporter signature motif; other site 234267006846 Walker B; other site 234267006847 D-loop; other site 234267006848 H-loop/switch region; other site 234267006849 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 234267006850 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 234267006851 putative active site [active] 234267006852 Trm112p-like protein; Region: Trm112p; cl01066 234267006853 Radical SAM superfamily; Region: Radical_SAM; pfam04055 234267006854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267006855 FeS/SAM binding site; other site 234267006856 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 234267006857 active site 234267006858 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267006859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267006860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267006861 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 234267006862 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 234267006863 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267006864 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267006865 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267006866 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267006867 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 234267006868 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 234267006869 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267006870 DNA binding residues [nucleotide binding] 234267006871 dimer interface [polypeptide binding]; other site 234267006872 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 234267006873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 234267006874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267006875 Walker A/P-loop; other site 234267006876 ATP binding site [chemical binding]; other site 234267006877 Q-loop/lid; other site 234267006878 ABC transporter signature motif; other site 234267006879 Walker B; other site 234267006880 D-loop; other site 234267006881 H-loop/switch region; other site 234267006882 TOBE domain; Region: TOBE_2; pfam08402 234267006883 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 234267006884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267006885 dimer interface [polypeptide binding]; other site 234267006886 conserved gate region; other site 234267006887 putative PBP binding loops; other site 234267006888 ABC-ATPase subunit interface; other site 234267006889 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 234267006890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267006891 dimer interface [polypeptide binding]; other site 234267006892 conserved gate region; other site 234267006893 putative PBP binding loops; other site 234267006894 ABC-ATPase subunit interface; other site 234267006895 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 234267006896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 234267006897 High-affinity nickel-transport protein; Region: NicO; cl00964 234267006898 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 234267006899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267006900 putative catalytic residue [active] 234267006901 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267006902 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267006903 Cytochrome c; Region: Cytochrom_C; cl11414 234267006904 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267006905 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267006906 Active site serine [active] 234267006907 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267006908 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234267006909 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 234267006910 active site 234267006911 catalytic triad [active] 234267006912 dimer interface [polypeptide binding]; other site 234267006913 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267006914 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267006915 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267006916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267006917 binding surface 234267006918 TPR motif; other site 234267006919 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267006920 CHAT domain; Region: CHAT; pfam12770 234267006921 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267006922 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267006923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006924 S-adenosylmethionine binding site [chemical binding]; other site 234267006925 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 234267006926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267006927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267006928 putative substrate translocation pore; other site 234267006929 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267006930 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267006931 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267006932 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006933 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267006934 FtsX-like permease family; Region: FtsX; pfam02687 234267006935 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267006936 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 234267006937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267006938 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 234267006939 substrate binding pocket [chemical binding]; other site 234267006940 membrane-bound complex binding site; other site 234267006941 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234267006942 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267006943 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267006944 catalytic residue [active] 234267006945 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 234267006946 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 234267006947 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 234267006948 catalytic site [active] 234267006949 subunit interface [polypeptide binding]; other site 234267006950 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 234267006951 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234267006952 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 234267006953 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 234267006954 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234267006955 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234267006956 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 234267006957 IMP binding site; other site 234267006958 dimer interface [polypeptide binding]; other site 234267006959 interdomain contacts; other site 234267006960 partial ornithine binding site; other site 234267006961 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267006962 active site 234267006963 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267006964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267006965 S-adenosylmethionine binding site [chemical binding]; other site 234267006966 Hemerythrin; Region: Hemerythrin; cd12107 234267006967 Fe binding site [ion binding]; other site 234267006968 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 234267006969 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 234267006970 active site 234267006971 interdomain interaction site; other site 234267006972 putative metal-binding site [ion binding]; other site 234267006973 nucleotide binding site [chemical binding]; other site 234267006974 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 234267006975 domain I; other site 234267006976 DNA binding groove [nucleotide binding] 234267006977 phosphate binding site [ion binding]; other site 234267006978 domain II; other site 234267006979 domain III; other site 234267006980 nucleotide binding site [chemical binding]; other site 234267006981 catalytic site [active] 234267006982 domain IV; other site 234267006983 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 234267006984 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 234267006985 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 234267006986 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 234267006987 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 234267006988 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 234267006989 DNA protecting protein DprA; Region: dprA; TIGR00732 234267006990 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 234267006991 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234267006992 Di-iron ligands [ion binding]; other site 234267006993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267006994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267006995 dimer interface [polypeptide binding]; other site 234267006996 phosphorylation site [posttranslational modification] 234267006997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267006998 ATP binding site [chemical binding]; other site 234267006999 Mg2+ binding site [ion binding]; other site 234267007000 G-X-G motif; other site 234267007001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267007002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007003 active site 234267007004 phosphorylation site [posttranslational modification] 234267007005 intermolecular recognition site; other site 234267007006 dimerization interface [polypeptide binding]; other site 234267007007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267007008 DNA binding site [nucleotide binding] 234267007009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267007010 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267007011 active site 234267007012 metal binding site [ion binding]; metal-binding site 234267007013 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007014 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 234267007015 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 234267007016 putative active site [active] 234267007017 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007020 FtsX-like permease family; Region: FtsX; pfam02687 234267007021 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267007022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267007023 metal ion-dependent adhesion site (MIDAS); other site 234267007024 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 234267007025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267007026 FeS/SAM binding site; other site 234267007027 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234267007028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267007029 Coenzyme A binding pocket [chemical binding]; other site 234267007030 PEP-CTERM motif; Region: VPEP; pfam07589 234267007031 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 234267007032 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 234267007033 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234267007034 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267007035 catalytic loop [active] 234267007036 iron binding site [ion binding]; other site 234267007037 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267007038 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267007039 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267007040 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267007041 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 234267007042 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 234267007043 P-loop containing region of AAA domain; Region: AAA_29; cl17516 234267007044 AAA domain; Region: AAA_23; pfam13476 234267007045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267007046 AAA domain; Region: AAA_21; pfam13304 234267007047 Walker A/P-loop; other site 234267007048 ATP binding site [chemical binding]; other site 234267007049 Q-loop/lid; other site 234267007050 ABC transporter signature motif; other site 234267007051 AAA domain; Region: AAA_21; pfam13304 234267007052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 234267007053 ABC transporter signature motif; other site 234267007054 Walker B; other site 234267007055 D-loop; other site 234267007056 H-loop/switch region; other site 234267007057 Family description; Region: VCBS; pfam13517 234267007058 FG-GAP repeat; Region: FG-GAP; pfam01839 234267007059 Family description; Region: VCBS; pfam13517 234267007060 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007061 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007063 FtsX-like permease family; Region: FtsX; pfam02687 234267007064 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 234267007065 MerT mercuric transport protein; Region: MerT; cl03578 234267007066 YCII-related domain; Region: YCII; cl00999 234267007067 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 234267007068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267007069 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267007070 DinB family; Region: DinB; cl17821 234267007071 DinB superfamily; Region: DinB_2; pfam12867 234267007072 hypothetical protein; Reviewed; Region: PRK12497 234267007073 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267007074 S-adenosylmethionine binding site [chemical binding]; other site 234267007075 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 234267007076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234267007077 inhibitor-cofactor binding pocket; inhibition site 234267007078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267007079 catalytic residue [active] 234267007080 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 234267007081 adenylosuccinate lyase; Provisional; Region: PRK07492 234267007082 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 234267007083 tetramer interface [polypeptide binding]; other site 234267007084 active site 234267007085 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 234267007086 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234267007087 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 234267007088 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234267007089 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 234267007090 putative NAD(P) binding site [chemical binding]; other site 234267007091 structural Zn binding site [ion binding]; other site 234267007092 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 234267007093 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234267007094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267007095 NAD(P) binding site [chemical binding]; other site 234267007096 active site 234267007097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267007098 putative DNA binding site [nucleotide binding]; other site 234267007099 putative Zn2+ binding site [ion binding]; other site 234267007100 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267007101 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 234267007102 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267007103 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 234267007104 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267007105 metal binding site [ion binding]; metal-binding site 234267007106 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234267007107 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267007108 inhibitor site; inhibition site 234267007109 active site 234267007110 dimer interface [polypeptide binding]; other site 234267007111 catalytic residue [active] 234267007112 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 234267007113 NHL repeat; Region: NHL; pfam01436 234267007114 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267007115 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267007116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267007117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007118 active site 234267007119 phosphorylation site [posttranslational modification] 234267007120 intermolecular recognition site; other site 234267007121 dimerization interface [polypeptide binding]; other site 234267007122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267007123 DNA binding residues [nucleotide binding] 234267007124 dimerization interface [polypeptide binding]; other site 234267007125 Histidine kinase; Region: HisKA_3; pfam07730 234267007126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267007127 ATP binding site [chemical binding]; other site 234267007128 Mg2+ binding site [ion binding]; other site 234267007129 G-X-G motif; other site 234267007130 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 234267007131 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234267007132 PYR/PP interface [polypeptide binding]; other site 234267007133 dimer interface [polypeptide binding]; other site 234267007134 TPP binding site [chemical binding]; other site 234267007135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267007136 transketolase; Reviewed; Region: PRK05899 234267007137 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 234267007138 TPP-binding site [chemical binding]; other site 234267007139 dimer interface [polypeptide binding]; other site 234267007140 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267007141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267007142 active site 234267007143 ATP binding site [chemical binding]; other site 234267007144 substrate binding site [chemical binding]; other site 234267007145 activation loop (A-loop); other site 234267007146 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267007147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267007148 active site 234267007149 ATP binding site [chemical binding]; other site 234267007150 substrate binding site [chemical binding]; other site 234267007151 activation loop (A-loop); other site 234267007152 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007153 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007154 FtsX-like permease family; Region: FtsX; pfam02687 234267007155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007156 FtsX-like permease family; Region: FtsX; pfam02687 234267007157 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267007158 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 234267007159 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 234267007160 dimer interface [polypeptide binding]; other site 234267007161 active site 234267007162 Schiff base residues; other site 234267007163 putative transposase OrfB; Reviewed; Region: PHA02517 234267007164 HTH-like domain; Region: HTH_21; pfam13276 234267007165 Integrase core domain; Region: rve; pfam00665 234267007166 Integrase core domain; Region: rve_3; pfam13683 234267007167 Transposase; Region: HTH_Tnp_1; pfam01527 234267007168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267007169 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234267007170 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267007171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267007172 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267007173 active site 234267007174 ATP binding site [chemical binding]; other site 234267007175 substrate binding site [chemical binding]; other site 234267007176 activation loop (A-loop); other site 234267007177 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267007178 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267007179 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267007180 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267007181 active site 234267007182 ATP binding site [chemical binding]; other site 234267007183 substrate binding site [chemical binding]; other site 234267007184 activation loop (A-loop); other site 234267007185 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267007186 TPR repeat; Region: TPR_11; pfam13414 234267007187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007188 TPR motif; other site 234267007189 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267007190 binding surface 234267007191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234267007192 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267007193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007194 DNA binding residues [nucleotide binding] 234267007195 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267007196 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267007197 active site 234267007198 ATP binding site [chemical binding]; other site 234267007199 substrate binding site [chemical binding]; other site 234267007200 activation loop (A-loop); other site 234267007201 TPR repeat; Region: TPR_11; pfam13414 234267007202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007203 binding surface 234267007204 TPR motif; other site 234267007205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267007206 S-adenosylmethionine binding site [chemical binding]; other site 234267007207 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 234267007208 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 234267007209 putative metal binding site [ion binding]; other site 234267007210 EamA-like transporter family; Region: EamA; pfam00892 234267007211 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 234267007212 EamA-like transporter family; Region: EamA; pfam00892 234267007213 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 234267007214 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267007215 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267007216 protein binding site [polypeptide binding]; other site 234267007217 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267007218 protein binding site [polypeptide binding]; other site 234267007219 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234267007220 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 234267007221 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267007222 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267007223 Walker A/P-loop; other site 234267007224 ATP binding site [chemical binding]; other site 234267007225 Q-loop/lid; other site 234267007226 ABC transporter signature motif; other site 234267007227 Walker B; other site 234267007228 D-loop; other site 234267007229 H-loop/switch region; other site 234267007230 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267007231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267007232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007233 DNA binding residues [nucleotide binding] 234267007234 seryl-tRNA synthetase; Provisional; Region: PRK05431 234267007235 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 234267007236 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 234267007237 dimer interface [polypeptide binding]; other site 234267007238 active site 234267007239 motif 1; other site 234267007240 motif 2; other site 234267007241 motif 3; other site 234267007242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267007243 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267007244 S-adenosylmethionine binding site [chemical binding]; other site 234267007245 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007246 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007247 FtsX-like permease family; Region: FtsX; pfam02687 234267007248 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007249 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267007250 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267007251 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 234267007252 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267007253 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267007254 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007255 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007256 FtsX-like permease family; Region: FtsX; pfam02687 234267007257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007258 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267007259 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 234267007260 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 234267007261 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 234267007262 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 234267007263 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 234267007264 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267007265 active site 234267007266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 234267007267 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 234267007268 Uncharacterized conserved protein [Function unknown]; Region: COG2308 234267007269 KpsF/GutQ family protein; Region: kpsF; TIGR00393 234267007270 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 234267007271 putative active site [active] 234267007272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 234267007273 hypothetical protein; Provisional; Region: PRK06815 234267007274 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 234267007275 tetramer interface [polypeptide binding]; other site 234267007276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267007277 catalytic residue [active] 234267007278 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267007279 Arginine repressor [Transcription]; Region: ArgR; COG1438 234267007280 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 234267007281 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 234267007282 argininosuccinate lyase; Provisional; Region: PRK00855 234267007283 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 234267007284 active sites [active] 234267007285 tetramer interface [polypeptide binding]; other site 234267007286 ornithine carbamoyltransferase; Provisional; Region: PRK14805 234267007287 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 234267007288 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 234267007289 Abi-like protein; Region: Abi_2; cl01988 234267007290 Phosphotransferase enzyme family; Region: APH; pfam01636 234267007291 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267007292 active site 234267007293 substrate binding site [chemical binding]; other site 234267007294 ATP binding site [chemical binding]; other site 234267007295 Transglycosylase; Region: Transgly; pfam00912 234267007296 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 234267007297 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 234267007298 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267007299 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267007300 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267007301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267007302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007303 DNA binding residues [nucleotide binding] 234267007304 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 234267007305 homodimer interface [polypeptide binding]; other site 234267007306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267007307 catalytic residue [active] 234267007308 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 234267007309 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 234267007310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267007311 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267007312 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 234267007313 Int/Topo IB signature motif; other site 234267007314 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267007315 active site 234267007316 DNA binding site [nucleotide binding] 234267007317 Int/Topo IB signature motif; other site 234267007318 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 234267007319 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 234267007320 Int/Topo IB signature motif; other site 234267007321 Domain of unknown function (DUF932); Region: DUF932; cl12129 234267007322 RHS Repeat; Region: RHS_repeat; pfam05593 234267007323 RHS Repeat; Region: RHS_repeat; pfam05593 234267007324 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 234267007325 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267007326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267007327 binding surface 234267007328 TPR motif; other site 234267007329 RHS Repeat; Region: RHS_repeat; pfam05593 234267007330 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 234267007331 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 234267007332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 234267007333 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 234267007334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 234267007335 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 234267007336 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 234267007337 Domain of unknown function DUF29; Region: DUF29; pfam01724 234267007338 PemK-like protein; Region: PemK; cl00995 234267007339 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 234267007340 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234267007341 nucleoside/Zn binding site; other site 234267007342 dimer interface [polypeptide binding]; other site 234267007343 catalytic motif [active] 234267007344 PAS domain S-box; Region: sensory_box; TIGR00229 234267007345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267007346 putative active site [active] 234267007347 heme pocket [chemical binding]; other site 234267007348 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267007349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267007350 DNA binding residues [nucleotide binding] 234267007351 dimerization interface [polypeptide binding]; other site 234267007352 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267007353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267007354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007355 DNA binding residues [nucleotide binding] 234267007356 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 234267007357 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 234267007358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234267007359 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267007360 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267007361 Protein required for attachment to host cells; Region: Host_attach; cl02398 234267007362 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267007363 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267007364 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007366 FtsX-like permease family; Region: FtsX; pfam02687 234267007367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007368 FtsX-like permease family; Region: FtsX; pfam02687 234267007369 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267007370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267007371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007372 DNA binding residues [nucleotide binding] 234267007373 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 234267007374 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 234267007375 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 234267007376 [2Fe-2S] cluster binding site [ion binding]; other site 234267007377 C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883 234267007378 putative alpha subunit interface [polypeptide binding]; other site 234267007379 putative active site [active] 234267007380 putative substrate binding site [chemical binding]; other site 234267007381 Fe binding site [ion binding]; other site 234267007382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267007383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267007384 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 234267007385 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 234267007386 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 234267007387 putative active site [active] 234267007388 putative NTP binding site [chemical binding]; other site 234267007389 putative nucleic acid binding site [nucleotide binding]; other site 234267007390 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 234267007391 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267007392 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 234267007393 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267007394 Trp docking motif [polypeptide binding]; other site 234267007395 putative active site [active] 234267007396 Cytochrome c; Region: Cytochrom_C; pfam00034 234267007397 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 234267007398 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 234267007399 Peptidase family M1; Region: Peptidase_M1; pfam01433 234267007400 Zn binding site [ion binding]; other site 234267007401 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 234267007402 RNA/DNA hybrid binding site [nucleotide binding]; other site 234267007403 active site 234267007404 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 234267007405 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007406 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267007407 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 234267007408 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 234267007409 RimM N-terminal domain; Region: RimM; pfam01782 234267007410 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 234267007411 hypothetical protein; Provisional; Region: PRK00468 234267007412 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 234267007413 signal recognition particle protein; Provisional; Region: PRK10867 234267007414 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 234267007415 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 234267007416 P loop; other site 234267007417 GTP binding site [chemical binding]; other site 234267007418 Signal peptide binding domain; Region: SRP_SPB; pfam02978 234267007419 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234267007420 DNA-binding site [nucleotide binding]; DNA binding site 234267007421 RNA-binding motif; other site 234267007422 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 234267007423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007426 binding surface 234267007427 TPR motif; other site 234267007428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007430 binding surface 234267007431 TPR motif; other site 234267007432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007433 EVE domain; Region: EVE; pfam01878 234267007434 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234267007435 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 234267007436 putative NAD(P) binding site [chemical binding]; other site 234267007437 putative substrate binding site [chemical binding]; other site 234267007438 catalytic Zn binding site [ion binding]; other site 234267007439 structural Zn binding site [ion binding]; other site 234267007440 dimer interface [polypeptide binding]; other site 234267007441 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267007442 Sulfatase; Region: Sulfatase; pfam00884 234267007443 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267007444 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234267007445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267007446 putative Zn2+ binding site [ion binding]; other site 234267007447 putative DNA binding site [nucleotide binding]; other site 234267007448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267007449 Coenzyme A binding pocket [chemical binding]; other site 234267007450 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 234267007451 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267007452 dimer interface [polypeptide binding]; other site 234267007453 putative metal binding site [ion binding]; other site 234267007454 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267007455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007456 DNA binding residues [nucleotide binding] 234267007457 Putative zinc-finger; Region: zf-HC2; pfam13490 234267007458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007460 binding surface 234267007461 TPR motif; other site 234267007462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007463 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007465 binding surface 234267007466 TPR motif; other site 234267007467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007468 CHAT domain; Region: CHAT; pfam12770 234267007469 Transposase; Region: HTH_Tnp_1; cl17663 234267007470 putative transposase OrfB; Reviewed; Region: PHA02517 234267007471 HTH-like domain; Region: HTH_21; pfam13276 234267007472 Integrase core domain; Region: rve; pfam00665 234267007473 Integrase core domain; Region: rve_3; pfam13683 234267007474 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267007475 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267007476 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267007477 Asp-box motif; other site 234267007478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267007479 non-specific DNA binding site [nucleotide binding]; other site 234267007480 salt bridge; other site 234267007481 sequence-specific DNA binding site [nucleotide binding]; other site 234267007482 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234267007483 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234267007484 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 234267007485 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 234267007486 active site 234267007487 Zn binding site [ion binding]; other site 234267007488 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234267007489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267007490 DNA-binding site [nucleotide binding]; DNA binding site 234267007491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267007492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267007493 homodimer interface [polypeptide binding]; other site 234267007494 catalytic residue [active] 234267007495 Trehalose utilisation; Region: ThuA; pfam06283 234267007496 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267007497 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 234267007498 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 234267007499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267007500 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 234267007501 trimer interface [polypeptide binding]; other site 234267007502 putative Zn binding site [ion binding]; other site 234267007503 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267007504 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267007505 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 234267007506 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007509 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 234267007510 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 234267007511 heme binding site [chemical binding]; other site 234267007512 ferroxidase pore; other site 234267007513 ferroxidase diiron center [ion binding]; other site 234267007514 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007515 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007516 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007517 FtsX-like permease family; Region: FtsX; pfam02687 234267007518 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 234267007519 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 234267007520 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267007521 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267007522 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267007523 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007524 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267007525 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234267007526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267007527 putative substrate translocation pore; other site 234267007528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267007529 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 234267007530 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267007531 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267007532 Outer membrane efflux protein; Region: OEP; pfam02321 234267007533 Outer membrane efflux protein; Region: OEP; pfam02321 234267007534 PA14 domain; Region: PA14; cl08459 234267007535 Right handed beta helix region; Region: Beta_helix; pfam13229 234267007536 Peptidase S46; Region: Peptidase_S46; pfam10459 234267007537 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267007538 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 234267007539 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267007540 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267007541 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267007542 active site pocket [active] 234267007543 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007544 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 234267007546 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 234267007547 AAA domain; Region: AAA_33; pfam13671 234267007548 AAA domain; Region: AAA_17; pfam13207 234267007549 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 234267007550 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 234267007551 active site 234267007552 metal binding site [ion binding]; metal-binding site 234267007553 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 234267007554 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 234267007555 active site 234267007556 benzoate transport; Region: 2A0115; TIGR00895 234267007557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267007558 putative substrate translocation pore; other site 234267007559 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267007560 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267007561 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267007562 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267007563 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 234267007564 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 234267007565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267007566 Coenzyme A binding pocket [chemical binding]; other site 234267007567 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267007568 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267007569 active site 234267007570 TDP-binding site; other site 234267007571 acceptor substrate-binding pocket; other site 234267007572 homodimer interface [polypeptide binding]; other site 234267007573 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234267007574 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 234267007575 putative di-iron ligands [ion binding]; other site 234267007576 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 234267007577 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 234267007578 dimer interface [polypeptide binding]; other site 234267007579 Penicillinase repressor; Region: Pencillinase_R; cl17580 234267007580 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267007581 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267007582 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 234267007583 VPS10 domain; Region: VPS10; smart00602 234267007584 VPS10 domain; Region: VPS10; smart00602 234267007585 Putative esterase; Region: Esterase; pfam00756 234267007586 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267007587 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 234267007588 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267007589 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267007590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267007591 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 234267007592 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267007593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267007594 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 234267007595 active site 234267007596 catalytic triad [active] 234267007597 oxyanion hole [active] 234267007598 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 234267007599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234267007600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267007601 Coenzyme A binding pocket [chemical binding]; other site 234267007602 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 234267007603 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 234267007604 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267007605 Domain of unknown function (DUF1736); Region: DUF1736; pfam08409 234267007606 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267007607 catalytic residues [active] 234267007608 BNR repeat-like domain; Region: BNR_2; pfam13088 234267007609 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 234267007610 Asp-box motif; other site 234267007611 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 234267007612 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 234267007613 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 234267007614 PA14 domain; Region: PA14; cl08459 234267007615 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 234267007616 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 234267007617 galactonate dehydratase; Provisional; Region: PRK14017 234267007618 putative active site pocket [active] 234267007619 putative metal binding site [ion binding]; other site 234267007620 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267007621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267007622 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267007623 PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820 234267007624 active site 234267007625 catalytic triad [active] 234267007626 oxyanion hole [active] 234267007627 specificity pocket; other site 234267007628 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007629 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 234267007630 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 234267007631 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 234267007632 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 234267007633 metal binding site [ion binding]; metal-binding site 234267007634 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267007635 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 234267007636 metal binding site [ion binding]; metal-binding site 234267007637 substrate binding pocket [chemical binding]; other site 234267007638 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 234267007639 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 234267007640 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 234267007641 B12 binding site [chemical binding]; other site 234267007642 cobalt ligand [ion binding]; other site 234267007643 Virulence factor; Region: Virulence_fact; pfam13769 234267007644 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 234267007645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267007646 catalytic loop [active] 234267007647 iron binding site [ion binding]; other site 234267007648 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 234267007649 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 234267007650 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 234267007651 Transposase IS200 like; Region: Y1_Tnp; cl00848 234267007652 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 234267007653 substrate binding site [chemical binding]; other site 234267007654 THF binding site; other site 234267007655 zinc-binding site [ion binding]; other site 234267007656 MarR family; Region: MarR_2; pfam12802 234267007657 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234267007658 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234267007659 nucleotide binding site [chemical binding]; other site 234267007660 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 234267007661 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 234267007662 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 234267007663 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 234267007664 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 234267007665 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 234267007666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267007667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007668 active site 234267007669 phosphorylation site [posttranslational modification] 234267007670 intermolecular recognition site; other site 234267007671 dimerization interface [polypeptide binding]; other site 234267007672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267007673 DNA binding residues [nucleotide binding] 234267007674 dimerization interface [polypeptide binding]; other site 234267007675 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 234267007676 Two component regulator propeller; Region: Reg_prop; pfam07494 234267007677 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 234267007678 Histidine kinase; Region: HisKA_3; pfam07730 234267007679 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234267007680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267007681 ATP binding site [chemical binding]; other site 234267007682 Mg2+ binding site [ion binding]; other site 234267007683 G-X-G motif; other site 234267007684 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007685 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267007686 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267007687 structural tetrad; other site 234267007688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267007689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267007690 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267007691 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 234267007692 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 234267007693 SLBB domain; Region: SLBB; pfam10531 234267007694 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267007695 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 234267007696 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 234267007697 Zn binding site [ion binding]; other site 234267007698 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 234267007699 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 234267007700 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267007701 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267007702 Thioredoxin; Region: Thioredoxin_4; pfam13462 234267007703 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 234267007704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267007705 DNA binding residues [nucleotide binding] 234267007706 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007707 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007708 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007709 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 234267007710 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 234267007711 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 234267007712 putative NAD(P) binding site [chemical binding]; other site 234267007713 active site 234267007714 putative sialic acid transporter; Region: 2A0112; TIGR00891 234267007715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267007716 putative substrate translocation pore; other site 234267007717 CAAX protease self-immunity; Region: Abi; pfam02517 234267007718 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 234267007719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267007720 S-adenosylmethionine binding site [chemical binding]; other site 234267007721 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 234267007722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267007723 Walker A motif; other site 234267007724 ATP binding site [chemical binding]; other site 234267007725 Walker B motif; other site 234267007726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234267007727 short chain dehydrogenase; Provisional; Region: PRK07326 234267007728 classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929 234267007729 putative NAD(P) binding site [chemical binding]; other site 234267007730 homodimer interface [polypeptide binding]; other site 234267007731 active site 234267007732 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 234267007733 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234267007734 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267007735 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267007736 catalytic residue [active] 234267007737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267007738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267007739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267007740 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007741 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007742 FtsX-like permease family; Region: FtsX; pfam02687 234267007743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007744 FtsX-like permease family; Region: FtsX; pfam02687 234267007745 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 234267007746 putative binding surface; other site 234267007747 active site 234267007748 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 234267007749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267007750 salt bridge; other site 234267007751 non-specific DNA binding site [nucleotide binding]; other site 234267007752 sequence-specific DNA binding site [nucleotide binding]; other site 234267007753 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 234267007754 acetylornithine aminotransferase; Provisional; Region: PRK02627 234267007755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234267007756 inhibitor-cofactor binding pocket; inhibition site 234267007757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267007758 catalytic residue [active] 234267007759 hypothetical protein; Provisional; Region: PRK08201 234267007760 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 234267007761 putative metal binding site [ion binding]; other site 234267007762 putative dimer interface [polypeptide binding]; other site 234267007763 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267007764 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 234267007765 Active site serine [active] 234267007766 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267007767 Active site serine [active] 234267007768 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267007769 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 234267007770 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 234267007771 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234267007772 RDD family; Region: RDD; pfam06271 234267007773 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 234267007774 Organic solvent tolerance protein; Region: OstA_C; pfam04453 234267007775 Bacterial Ig-like domain; Region: Big_5; pfam13205 234267007776 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267007777 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267007778 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007779 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267007780 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 234267007781 KduI/IolB family; Region: KduI; cl01508 234267007782 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234267007783 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234267007784 Bacterial transcriptional regulator; Region: IclR; pfam01614 234267007785 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 234267007786 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267007787 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267007788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267007789 binding surface 234267007790 TPR motif; other site 234267007791 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267007792 PilZ domain; Region: PilZ; cl01260 234267007793 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 234267007794 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 234267007795 Tetramer interface [polypeptide binding]; other site 234267007796 active site 234267007797 FMN-binding site [chemical binding]; other site 234267007798 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 234267007799 active site 234267007800 catalytic residues [active] 234267007801 metal binding site [ion binding]; metal-binding site 234267007802 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 234267007803 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 234267007804 putative active site [active] 234267007805 substrate binding site [chemical binding]; other site 234267007806 putative cosubstrate binding site; other site 234267007807 catalytic site [active] 234267007808 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 234267007809 substrate binding site [chemical binding]; other site 234267007810 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 234267007811 heterotetramer interface [polypeptide binding]; other site 234267007812 active site pocket [active] 234267007813 cleavage site 234267007814 Ion channel; Region: Ion_trans_2; pfam07885 234267007815 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 234267007816 TrkA-N domain; Region: TrkA_N; pfam02254 234267007817 TrkA-C domain; Region: TrkA_C; pfam02080 234267007818 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 234267007819 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 234267007820 putative active site [active] 234267007821 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 234267007822 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 234267007823 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 234267007824 active site 234267007825 catalytic triad [active] 234267007826 oxyanion hole [active] 234267007827 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 234267007828 5'-3' exonuclease; Region: 53EXOc; smart00475 234267007829 active site 234267007830 metal binding site 1 [ion binding]; metal-binding site 234267007831 putative 5' ssDNA interaction site; other site 234267007832 metal binding site 3; metal-binding site 234267007833 metal binding site 2 [ion binding]; metal-binding site 234267007834 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 234267007835 putative DNA binding site [nucleotide binding]; other site 234267007836 putative metal binding site [ion binding]; other site 234267007837 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267007838 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267007839 active site 234267007840 TDP-binding site; other site 234267007841 acceptor substrate-binding pocket; other site 234267007842 homodimer interface [polypeptide binding]; other site 234267007843 Putative Ig domain; Region: He_PIG; pfam05345 234267007844 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 234267007845 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267007846 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007847 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267007848 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267007849 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 234267007850 beta-galactosidase; Region: BGL; TIGR03356 234267007851 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 234267007852 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267007853 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267007854 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 234267007855 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267007856 active site 234267007857 Int/Topo IB signature motif; other site 234267007858 DNA binding site [nucleotide binding] 234267007859 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 234267007860 Putative transposase; Region: Y2_Tnp; pfam04986 234267007861 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007862 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267007863 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 234267007864 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234267007865 Cytochrome P450; Region: p450; cl12078 234267007866 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 234267007867 SnoaL-like domain; Region: SnoaL_2; pfam12680 234267007868 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 234267007869 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267007870 Disulphide isomerase; Region: Disulph_isomer; cl05813 234267007871 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 234267007872 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 234267007873 active site 234267007874 Zn binding site [ion binding]; other site 234267007875 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267007876 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007877 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267007878 FtsX-like permease family; Region: FtsX; pfam02687 234267007879 PAS fold; Region: PAS_4; pfam08448 234267007880 PAS domain; Region: PAS_9; pfam13426 234267007881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267007882 putative active site [active] 234267007883 heme pocket [chemical binding]; other site 234267007884 PAS fold; Region: PAS_4; pfam08448 234267007885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267007886 putative active site [active] 234267007887 heme pocket [chemical binding]; other site 234267007888 PAS domain S-box; Region: sensory_box; TIGR00229 234267007889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267007890 putative active site [active] 234267007891 heme pocket [chemical binding]; other site 234267007892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234267007893 Histidine kinase; Region: HisKA_3; pfam07730 234267007894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267007895 ATP binding site [chemical binding]; other site 234267007896 Mg2+ binding site [ion binding]; other site 234267007897 G-X-G motif; other site 234267007898 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267007899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007900 active site 234267007901 phosphorylation site [posttranslational modification] 234267007902 intermolecular recognition site; other site 234267007903 dimerization interface [polypeptide binding]; other site 234267007904 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267007905 DNA binding residues [nucleotide binding] 234267007906 dimerization interface [polypeptide binding]; other site 234267007907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267007908 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267007909 putative active site [active] 234267007910 heme pocket [chemical binding]; other site 234267007911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267007912 dimer interface [polypeptide binding]; other site 234267007913 phosphorylation site [posttranslational modification] 234267007914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267007915 ATP binding site [chemical binding]; other site 234267007916 Mg2+ binding site [ion binding]; other site 234267007917 G-X-G motif; other site 234267007918 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267007919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007920 active site 234267007921 phosphorylation site [posttranslational modification] 234267007922 intermolecular recognition site; other site 234267007923 dimerization interface [polypeptide binding]; other site 234267007924 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 234267007925 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267007926 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 234267007927 protein binding site [polypeptide binding]; other site 234267007928 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 234267007929 Catalytic dyad [active] 234267007930 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267007931 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267007932 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267007933 metal binding site [ion binding]; metal-binding site 234267007934 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 234267007935 putative ligand binding site [chemical binding]; other site 234267007936 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 234267007937 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 234267007938 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 234267007939 Arginase family; Region: Arginase; cd09989 234267007940 agmatinase; Region: agmatinase; TIGR01230 234267007941 active site 234267007942 Mn binding site [ion binding]; other site 234267007943 oligomer interface [polypeptide binding]; other site 234267007944 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 234267007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007946 active site 234267007947 phosphorylation site [posttranslational modification] 234267007948 intermolecular recognition site; other site 234267007949 dimerization interface [polypeptide binding]; other site 234267007950 PAS domain S-box; Region: sensory_box; TIGR00229 234267007951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267007952 putative active site [active] 234267007953 heme pocket [chemical binding]; other site 234267007954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267007955 ATP binding site [chemical binding]; other site 234267007956 Mg2+ binding site [ion binding]; other site 234267007957 G-X-G motif; other site 234267007958 Response regulator receiver domain; Region: Response_reg; pfam00072 234267007959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007960 active site 234267007961 phosphorylation site [posttranslational modification] 234267007962 intermolecular recognition site; other site 234267007963 dimerization interface [polypeptide binding]; other site 234267007964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267007965 dimer interface [polypeptide binding]; other site 234267007966 phosphorylation site [posttranslational modification] 234267007967 Response regulator receiver domain; Region: Response_reg; pfam00072 234267007968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267007969 active site 234267007970 phosphorylation site [posttranslational modification] 234267007971 intermolecular recognition site; other site 234267007972 dimerization interface [polypeptide binding]; other site 234267007973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 234267007974 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 234267007975 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 234267007976 putative dimer interface [polypeptide binding]; other site 234267007977 putative anticodon binding site; other site 234267007978 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 234267007979 homodimer interface [polypeptide binding]; other site 234267007980 motif 1; other site 234267007981 motif 2; other site 234267007982 active site 234267007983 motif 3; other site 234267007984 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267007985 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 234267007986 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 234267007987 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 234267007988 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 234267007989 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 234267007990 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234267007991 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 234267007992 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234267007993 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 234267007994 active site 234267007995 8-oxo-dGMP binding site [chemical binding]; other site 234267007996 nudix motif; other site 234267007997 metal binding site [ion binding]; metal-binding site 234267007998 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 234267007999 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 234267008000 trimerization site [polypeptide binding]; other site 234267008001 active site 234267008002 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267008003 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008004 FtsX-like permease family; Region: FtsX; pfam02687 234267008005 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008006 FtsX-like permease family; Region: FtsX; pfam02687 234267008007 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267008008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008009 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267008011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267008012 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 234267008013 IPT/TIG domain; Region: TIG; pfam01833 234267008014 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267008015 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 234267008016 active site 234267008017 catalytic residues [active] 234267008018 alpha-galactosidase; Region: PLN02808; cl17638 234267008019 Protein of unknown function (DUF3738); Region: DUF3738; pfam12543 234267008020 NIPSNAP; Region: NIPSNAP; pfam07978 234267008021 Amino acid permease; Region: AA_permease_2; pfam13520 234267008022 isocitrate dehydrogenase; Validated; Region: PRK09222 234267008023 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 234267008024 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 234267008025 nucleotide binding site/active site [active] 234267008026 HIT family signature motif; other site 234267008027 catalytic residue [active] 234267008028 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 234267008029 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 234267008030 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267008031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267008032 S-adenosylmethionine binding site [chemical binding]; other site 234267008033 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267008034 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267008035 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 234267008036 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267008037 Beta-Casp domain; Region: Beta-Casp; smart01027 234267008038 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 234267008039 Transposase IS200 like; Region: Y1_Tnp; cl00848 234267008040 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267008041 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267008042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267008043 active site 234267008044 ATP binding site [chemical binding]; other site 234267008045 substrate binding site [chemical binding]; other site 234267008046 activation loop (A-loop); other site 234267008047 AAA ATPase domain; Region: AAA_16; pfam13191 234267008048 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 234267008049 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 234267008050 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 234267008051 putative active site [active] 234267008052 putative metal binding site [ion binding]; other site 234267008053 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267008054 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008055 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234267008056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267008057 non-specific DNA binding site [nucleotide binding]; other site 234267008058 salt bridge; other site 234267008059 sequence-specific DNA binding site [nucleotide binding]; other site 234267008060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234267008061 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267008062 anti sigma factor interaction site; other site 234267008063 regulatory phosphorylation site [posttranslational modification]; other site 234267008064 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 234267008065 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 234267008066 putative DNA binding site [nucleotide binding]; other site 234267008067 catalytic residue [active] 234267008068 putative H2TH interface [polypeptide binding]; other site 234267008069 putative catalytic residues [active] 234267008070 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234267008071 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234267008072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267008073 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 234267008074 ATP binding site [chemical binding]; other site 234267008075 putative Mg++ binding site [ion binding]; other site 234267008076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267008077 nucleotide binding region [chemical binding]; other site 234267008078 ATP-binding site [chemical binding]; other site 234267008079 DEAD/H associated; Region: DEAD_assoc; pfam08494 234267008080 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 234267008081 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 234267008082 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 234267008083 trimer interface [polypeptide binding]; other site 234267008084 active site 234267008085 UDP-GlcNAc binding site [chemical binding]; other site 234267008086 lipid binding site [chemical binding]; lipid-binding site 234267008087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267008088 S-adenosylmethionine binding site [chemical binding]; other site 234267008089 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 234267008090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267008091 FeS/SAM binding site; other site 234267008092 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 234267008093 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 234267008094 active site 234267008095 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 234267008096 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 234267008097 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 234267008098 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 234267008099 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 234267008100 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267008101 putative NAD(P) binding site [chemical binding]; other site 234267008102 catalytic Zn binding site [ion binding]; other site 234267008103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008104 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008105 active site 234267008106 catalytic tetrad [active] 234267008107 TPR repeat; Region: TPR_11; pfam13414 234267008108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008109 binding surface 234267008110 TPR motif; other site 234267008111 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267008112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008113 TPR motif; other site 234267008114 binding surface 234267008115 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008116 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267008117 FtsX-like permease family; Region: FtsX; pfam02687 234267008118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008120 active site 234267008121 catalytic tetrad [active] 234267008122 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234267008123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234267008124 nucleotide binding site [chemical binding]; other site 234267008125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267008126 classical (c) SDRs; Region: SDR_c; cd05233 234267008127 NAD(P) binding site [chemical binding]; other site 234267008128 active site 234267008129 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 234267008130 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267008131 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267008132 ligand binding site [chemical binding]; other site 234267008133 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 234267008134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267008135 Histidine kinase; Region: HisKA_3; pfam07730 234267008136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267008137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008138 active site 234267008139 phosphorylation site [posttranslational modification] 234267008140 intermolecular recognition site; other site 234267008141 dimerization interface [polypeptide binding]; other site 234267008142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267008143 DNA binding residues [nucleotide binding] 234267008144 dimerization interface [polypeptide binding]; other site 234267008145 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267008146 Sulfatase; Region: Sulfatase; pfam00884 234267008147 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 234267008148 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 234267008149 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 234267008150 Methane oxygenase PmoA; Region: PmoA; pfam14100 234267008151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267008152 kynureninase; Region: kynureninase; TIGR01814 234267008153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267008154 catalytic residue [active] 234267008155 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 234267008156 putative ligand binding site [chemical binding]; other site 234267008157 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 234267008158 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234267008159 B12 binding domain; Region: B12-binding_2; cl03653 234267008160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267008161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267008162 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267008163 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267008164 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267008165 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267008166 GAF domain; Region: GAF; cl17456 234267008167 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267008168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008169 putative active site [active] 234267008170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267008171 heme pocket [chemical binding]; other site 234267008172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267008173 dimer interface [polypeptide binding]; other site 234267008174 phosphorylation site [posttranslational modification] 234267008175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008176 ATP binding site [chemical binding]; other site 234267008177 Mg2+ binding site [ion binding]; other site 234267008178 G-X-G motif; other site 234267008179 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267008180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267008181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267008182 DNA binding residues [nucleotide binding] 234267008183 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008185 active site 234267008186 phosphorylation site [posttranslational modification] 234267008187 intermolecular recognition site; other site 234267008188 dimerization interface [polypeptide binding]; other site 234267008189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234267008190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267008191 Walker A motif; other site 234267008192 ATP binding site [chemical binding]; other site 234267008193 Walker B motif; other site 234267008194 arginine finger; other site 234267008195 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267008196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267008197 dimer interface [polypeptide binding]; other site 234267008198 phosphorylation site [posttranslational modification] 234267008199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008200 ATP binding site [chemical binding]; other site 234267008201 Mg2+ binding site [ion binding]; other site 234267008202 G-X-G motif; other site 234267008203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008204 Response regulator receiver domain; Region: Response_reg; pfam00072 234267008205 active site 234267008206 phosphorylation site [posttranslational modification] 234267008207 intermolecular recognition site; other site 234267008208 dimerization interface [polypeptide binding]; other site 234267008209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008210 active site 234267008211 phosphorylation site [posttranslational modification] 234267008212 intermolecular recognition site; other site 234267008213 dimerization interface [polypeptide binding]; other site 234267008214 PAS domain S-box; Region: sensory_box; TIGR00229 234267008215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008216 putative active site [active] 234267008217 heme pocket [chemical binding]; other site 234267008218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267008219 dimer interface [polypeptide binding]; other site 234267008220 phosphorylation site [posttranslational modification] 234267008221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008222 ATP binding site [chemical binding]; other site 234267008223 Mg2+ binding site [ion binding]; other site 234267008224 G-X-G motif; other site 234267008225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008226 Response regulator receiver domain; Region: Response_reg; pfam00072 234267008227 active site 234267008228 phosphorylation site [posttranslational modification] 234267008229 intermolecular recognition site; other site 234267008230 dimerization interface [polypeptide binding]; other site 234267008231 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 234267008232 PAS fold; Region: PAS_3; pfam08447 234267008233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008234 putative active site [active] 234267008235 heme pocket [chemical binding]; other site 234267008236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008237 putative active site [active] 234267008238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008239 ATP binding site [chemical binding]; other site 234267008240 Mg2+ binding site [ion binding]; other site 234267008241 G-X-G motif; other site 234267008242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008243 Response regulator receiver domain; Region: Response_reg; pfam00072 234267008244 active site 234267008245 phosphorylation site [posttranslational modification] 234267008246 intermolecular recognition site; other site 234267008247 dimerization interface [polypeptide binding]; other site 234267008248 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 234267008249 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 234267008250 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 234267008251 active site 234267008252 catalytic site [active] 234267008253 4-alpha-glucanotransferase; Provisional; Region: PRK14508 234267008254 phosphoglucomutase; Validated; Region: PRK07564 234267008255 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 234267008256 active site 234267008257 substrate binding site [chemical binding]; other site 234267008258 metal binding site [ion binding]; metal-binding site 234267008259 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 234267008260 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267008261 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267008262 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267008263 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 234267008264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267008265 Walker A motif; other site 234267008266 ATP binding site [chemical binding]; other site 234267008267 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 234267008268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267008269 active site 234267008270 DNA binding site [nucleotide binding] 234267008271 Int/Topo IB signature motif; other site 234267008272 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 234267008273 DNA methylase; Region: N6_N4_Mtase; pfam01555 234267008274 AAA-like domain; Region: AAA_10; pfam12846 234267008275 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 234267008276 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 234267008277 XdhC Rossmann domain; Region: XdhC_C; pfam13478 234267008278 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267008279 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267008280 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267008281 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267008282 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267008283 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234267008284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267008285 catalytic loop [active] 234267008286 iron binding site [ion binding]; other site 234267008287 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267008288 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234267008289 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 234267008290 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267008291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267008292 Histidine kinase; Region: His_kinase; pfam06580 234267008293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008294 ATP binding site [chemical binding]; other site 234267008295 Mg2+ binding site [ion binding]; other site 234267008296 G-X-G motif; other site 234267008297 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267008298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008299 active site 234267008300 phosphorylation site [posttranslational modification] 234267008301 intermolecular recognition site; other site 234267008302 dimerization interface [polypeptide binding]; other site 234267008303 LytTr DNA-binding domain; Region: LytTR; smart00850 234267008304 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 234267008305 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234267008306 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008307 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008308 active site 234267008309 catalytic tetrad [active] 234267008310 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008311 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008312 active site 234267008313 catalytic tetrad [active] 234267008314 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267008315 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267008316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008318 active site 234267008319 catalytic tetrad [active] 234267008320 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 234267008321 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 234267008322 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 234267008323 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267008324 catalytic site [active] 234267008325 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 234267008326 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 234267008327 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267008328 Carboxylesterase family; Region: COesterase; pfam00135 234267008329 substrate binding pocket [chemical binding]; other site 234267008330 catalytic triad [active] 234267008331 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267008332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267008333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267008334 DNA binding residues [nucleotide binding] 234267008335 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267008336 catalytic loop [active] 234267008337 iron binding site [ion binding]; other site 234267008338 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267008339 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267008340 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267008341 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 234267008342 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 234267008343 Hemerythrin-like domain; Region: Hr-like; cd12108 234267008344 Uncharacterized conserved protein [Function unknown]; Region: COG2461 234267008345 Family of unknown function (DUF438); Region: DUF438; pfam04282 234267008346 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 234267008347 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 234267008348 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 234267008349 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234267008350 iron-sulfur cluster [ion binding]; other site 234267008351 [2Fe-2S] cluster binding site [ion binding]; other site 234267008352 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 234267008353 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 234267008354 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 234267008355 [4Fe-4S] binding site [ion binding]; other site 234267008356 molybdopterin cofactor binding site; other site 234267008357 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 234267008358 molybdopterin cofactor binding site; other site 234267008359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267008360 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 234267008361 putative substrate translocation pore; other site 234267008362 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 234267008363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267008364 FeS/SAM binding site; other site 234267008365 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 234267008366 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267008367 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267008368 ligand binding site [chemical binding]; other site 234267008369 flexible hinge region; other site 234267008370 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 234267008371 putative switch regulator; other site 234267008372 non-specific DNA interactions [nucleotide binding]; other site 234267008373 DNA binding site [nucleotide binding] 234267008374 sequence specific DNA binding site [nucleotide binding]; other site 234267008375 putative cAMP binding site [chemical binding]; other site 234267008376 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 234267008377 Hemerythrin-like domain; Region: Hr-like; cd12108 234267008378 Fe binding site [ion binding]; other site 234267008379 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 234267008380 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234267008381 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234267008382 alpha subunit interface [polypeptide binding]; other site 234267008383 TPP binding site [chemical binding]; other site 234267008384 heterodimer interface [polypeptide binding]; other site 234267008385 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267008386 KTSC domain; Region: KTSC; pfam13619 234267008387 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 234267008388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 234267008389 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 234267008390 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 234267008391 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267008392 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 234267008393 Int/Topo IB signature motif; other site 234267008394 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 234267008395 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267008396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267008397 active site 234267008398 DNA binding site [nucleotide binding] 234267008399 Int/Topo IB signature motif; other site 234267008400 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 234267008401 multiple promoter invertase; Provisional; Region: mpi; PRK13413 234267008402 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234267008403 catalytic residues [active] 234267008404 catalytic nucleophile [active] 234267008405 Presynaptic Site I dimer interface [polypeptide binding]; other site 234267008406 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234267008407 Synaptic Flat tetramer interface [polypeptide binding]; other site 234267008408 Synaptic Site I dimer interface [polypeptide binding]; other site 234267008409 DNA binding site [nucleotide binding] 234267008410 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 234267008411 DNA-binding interface [nucleotide binding]; DNA binding site 234267008412 KTSC domain; Region: KTSC; pfam13619 234267008413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267008414 Walker A motif; other site 234267008415 ATP binding site [chemical binding]; other site 234267008416 Walker B motif; other site 234267008417 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 234267008418 active site 234267008419 catalytic site [active] 234267008420 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267008421 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267008422 metal ion-dependent adhesion site (MIDAS); other site 234267008423 malate dehydrogenase; Provisional; Region: PRK13529 234267008424 Malic enzyme, N-terminal domain; Region: malic; pfam00390 234267008425 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 234267008426 NAD(P) binding site [chemical binding]; other site 234267008427 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 234267008428 CsbD-like; Region: CsbD; cl17424 234267008429 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267008430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267008431 ligand binding site [chemical binding]; other site 234267008432 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 234267008433 putative amphipathic alpha helix; other site 234267008434 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234267008435 Domain of unknown function DUF20; Region: UPF0118; pfam01594 234267008436 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 234267008437 Response regulator receiver domain; Region: Response_reg; pfam00072 234267008438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008439 active site 234267008440 phosphorylation site [posttranslational modification] 234267008441 intermolecular recognition site; other site 234267008442 dimerization interface [polypeptide binding]; other site 234267008443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008444 PAS domain; Region: PAS_9; pfam13426 234267008445 putative active site [active] 234267008446 heme pocket [chemical binding]; other site 234267008447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008448 PAS domain; Region: PAS_9; pfam13426 234267008449 putative active site [active] 234267008450 heme pocket [chemical binding]; other site 234267008451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008452 PAS domain; Region: PAS_9; pfam13426 234267008453 putative active site [active] 234267008454 heme pocket [chemical binding]; other site 234267008455 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 234267008456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267008457 Walker A motif; other site 234267008458 ATP binding site [chemical binding]; other site 234267008459 Walker B motif; other site 234267008460 arginine finger; other site 234267008461 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267008462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267008463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267008464 active site 234267008465 metal binding site [ion binding]; metal-binding site 234267008466 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267008467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267008468 active site 234267008469 metal binding site [ion binding]; metal-binding site 234267008470 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008471 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008472 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267008473 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008474 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008475 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008476 active site 234267008477 catalytic tetrad [active] 234267008478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267008479 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267008480 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 234267008481 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008482 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267008483 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267008484 galactonate dehydratase; Provisional; Region: PRK14017 234267008485 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 234267008486 putative active site pocket [active] 234267008487 putative metal binding site [ion binding]; other site 234267008488 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 234267008489 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267008490 metal binding site [ion binding]; metal-binding site 234267008491 substrate binding pocket [chemical binding]; other site 234267008492 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267008493 Carbohydrate-binding protein of the ER; Region: Malectin_like; pfam12819 234267008494 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267008495 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008496 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008497 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 234267008498 Putative esterase; Region: Esterase; pfam00756 234267008499 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267008500 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 234267008501 substrate binding site [chemical binding]; other site 234267008502 active site 234267008503 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 234267008504 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 234267008505 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 234267008506 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267008507 Putative esterase; Region: Esterase; pfam00756 234267008508 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267008509 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 234267008510 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 234267008511 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 234267008512 active site 234267008513 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267008514 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 234267008515 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267008516 NAD binding site [chemical binding]; other site 234267008517 catalytic Zn binding site [ion binding]; other site 234267008518 structural Zn binding site [ion binding]; other site 234267008519 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 234267008520 putative hydrophobic ligand binding site [chemical binding]; other site 234267008521 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234267008522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267008523 NAD(P) binding site [chemical binding]; other site 234267008524 active site 234267008525 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234267008526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267008527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267008528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267008529 Walker A/P-loop; other site 234267008530 ATP binding site [chemical binding]; other site 234267008531 Q-loop/lid; other site 234267008532 ABC transporter signature motif; other site 234267008533 Walker B; other site 234267008534 D-loop; other site 234267008535 H-loop/switch region; other site 234267008536 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 234267008537 active site 234267008538 catalytic site [active] 234267008539 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 234267008540 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008541 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 234267008542 dimer interface [polypeptide binding]; other site 234267008543 substrate binding site [chemical binding]; other site 234267008544 metal binding sites [ion binding]; metal-binding site 234267008545 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234267008546 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 234267008547 putative NAD(P) binding site [chemical binding]; other site 234267008548 active site 234267008549 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 234267008550 short chain dehydrogenase; Provisional; Region: PRK06701 234267008551 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 234267008552 NAD binding site [chemical binding]; other site 234267008553 metal binding site [ion binding]; metal-binding site 234267008554 active site 234267008555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267008556 active site 234267008557 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267008558 catalytic tetrad [active] 234267008559 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267008560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267008561 NAD(P) binding site [chemical binding]; other site 234267008562 active site 234267008563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267008564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267008565 NAD(P) binding site [chemical binding]; other site 234267008566 active site 234267008567 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 234267008568 B12 binding domain; Region: B12-binding; pfam02310 234267008569 B12 binding site [chemical binding]; other site 234267008570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267008571 FeS/SAM binding site; other site 234267008572 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267008573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267008574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 234267008575 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 234267008576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 234267008577 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 234267008578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 234267008579 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 234267008580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234267008581 catalytic core [active] 234267008582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 234267008583 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267008584 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 234267008585 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 234267008586 active site 234267008587 Substrate binding site; other site 234267008588 Mg++ binding site; other site 234267008589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267008590 S-adenosylmethionine binding site [chemical binding]; other site 234267008591 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 234267008592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267008593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267008594 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 234267008595 putative ADP-binding pocket [chemical binding]; other site 234267008596 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267008597 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 234267008598 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 234267008599 4Fe-4S binding domain; Region: Fer4; pfam00037 234267008600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267008601 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 234267008602 active site 234267008603 DNA binding site [nucleotide binding] 234267008604 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 234267008605 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 234267008606 DNA binding site [nucleotide binding] 234267008607 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 234267008608 nucleotide binding site [chemical binding]; other site 234267008609 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 234267008610 dimer interface [polypeptide binding]; other site 234267008611 substrate binding site [chemical binding]; other site 234267008612 metal binding sites [ion binding]; metal-binding site 234267008613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267008614 dimerization interface [polypeptide binding]; other site 234267008615 putative DNA binding site [nucleotide binding]; other site 234267008616 putative Zn2+ binding site [ion binding]; other site 234267008617 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 234267008618 putative hydrophobic ligand binding site [chemical binding]; other site 234267008619 DoxX-like family; Region: DoxX_2; pfam13564 234267008620 Uncharacterized conserved protein [Function unknown]; Region: COG5649 234267008621 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 234267008622 propionate/acetate kinase; Provisional; Region: PRK12379 234267008623 xylose isomerase; Provisional; Region: PRK05474 234267008624 xylose isomerase; Region: xylose_isom_A; TIGR02630 234267008625 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267008626 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 234267008627 ligand binding site [chemical binding]; other site 234267008628 dimerization interface [polypeptide binding]; other site 234267008629 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008630 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267008631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267008632 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 234267008633 active site 234267008634 catalytic residues [active] 234267008635 Carboxylesterase family; Region: COesterase; pfam00135 234267008636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267008637 substrate binding pocket [chemical binding]; other site 234267008638 catalytic triad [active] 234267008639 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234267008640 Peptidase family M23; Region: Peptidase_M23; pfam01551 234267008641 DinB family; Region: DinB; cl17821 234267008642 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267008643 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267008644 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267008645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008646 FtsX-like permease family; Region: FtsX; pfam02687 234267008647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008648 FtsX-like permease family; Region: FtsX; pfam02687 234267008649 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267008650 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008651 FtsX-like permease family; Region: FtsX; pfam02687 234267008652 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267008653 FtsX-like permease family; Region: FtsX; pfam02687 234267008654 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267008655 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267008656 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 234267008657 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 234267008658 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234267008659 Multicopper oxidase; Region: Cu-oxidase; pfam00394 234267008660 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234267008661 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267008662 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 234267008663 active site 234267008664 Zn binding site [ion binding]; other site 234267008665 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008666 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267008667 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008668 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008669 active site 234267008670 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267008671 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 234267008672 Putative esterase; Region: Esterase; pfam00756 234267008673 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267008674 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 234267008675 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267008676 Putative esterase; Region: Esterase; pfam00756 234267008677 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267008678 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267008679 Trp docking motif [polypeptide binding]; other site 234267008680 active site 234267008681 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267008682 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 234267008683 Trehalose utilisation; Region: ThuA; pfam06283 234267008684 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267008685 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 234267008686 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 234267008687 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 234267008688 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234267008689 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 234267008690 active site 234267008691 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234267008692 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 234267008693 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 234267008694 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 234267008695 active site 234267008696 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 234267008697 putative NADP binding site [chemical binding]; other site 234267008698 active site 234267008699 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 234267008700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234267008701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234267008702 active site 234267008703 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 234267008704 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 234267008705 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 234267008706 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 234267008707 Ligand binding site [chemical binding]; other site 234267008708 Electron transfer flavoprotein domain; Region: ETF; pfam01012 234267008709 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 234267008710 Cysteine-rich domain; Region: CCG; pfam02754 234267008711 Cysteine-rich domain; Region: CCG; pfam02754 234267008712 Uncharacterized conserved protein [Function unknown]; Region: COG3595 234267008713 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267008714 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 234267008715 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 234267008716 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 234267008717 active site 234267008718 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008719 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008720 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267008721 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234267008722 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234267008723 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 234267008724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267008725 S-adenosylmethionine binding site [chemical binding]; other site 234267008726 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 234267008727 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234267008728 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234267008729 shikimate binding site; other site 234267008730 NAD(P) binding site [chemical binding]; other site 234267008731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267008732 D-galactonate transporter; Region: 2A0114; TIGR00893 234267008733 putative substrate translocation pore; other site 234267008734 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267008735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008736 TPR motif; other site 234267008737 TPR repeat; Region: TPR_11; pfam13414 234267008738 binding surface 234267008739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008740 binding surface 234267008741 TPR motif; other site 234267008742 TPR repeat; Region: TPR_11; pfam13414 234267008743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008744 TPR repeat; Region: TPR_11; pfam13414 234267008745 TPR motif; other site 234267008746 binding surface 234267008747 Trehalose utilisation; Region: ThuA; pfam06283 234267008748 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008749 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008750 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267008751 Trp docking motif [polypeptide binding]; other site 234267008752 putative active site [active] 234267008753 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 234267008754 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 234267008755 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234267008756 PYR/PP interface [polypeptide binding]; other site 234267008757 dimer interface [polypeptide binding]; other site 234267008758 TPP binding site [chemical binding]; other site 234267008759 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267008760 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 234267008761 TPP-binding site [chemical binding]; other site 234267008762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267008763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267008764 putative substrate translocation pore; other site 234267008765 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 234267008766 putative catalytic cysteine [active] 234267008767 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 234267008768 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 234267008769 active site 234267008770 oxalacetate binding site [chemical binding]; other site 234267008771 citrylCoA binding site [chemical binding]; other site 234267008772 coenzyme A binding site [chemical binding]; other site 234267008773 catalytic triad [active] 234267008774 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267008775 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267008776 active site pocket [active] 234267008777 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008778 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267008779 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267008780 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234267008781 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234267008782 Bacterial transcriptional regulator; Region: IclR; pfam01614 234267008783 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 234267008784 malate synthase A; Region: malate_syn_A; TIGR01344 234267008785 active site 234267008786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234267008787 active site 234267008788 metal binding site [ion binding]; metal-binding site 234267008789 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008790 Sulfatase; Region: Sulfatase; cl17466 234267008791 HYR domain; Region: HYR; pfam02494 234267008792 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 234267008793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267008794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267008795 phosphorylation site [posttranslational modification] 234267008796 dimer interface [polypeptide binding]; other site 234267008797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008798 ATP binding site [chemical binding]; other site 234267008799 G-X-G motif; other site 234267008800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267008801 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267008802 DNA binding site [nucleotide binding] 234267008803 Predicted ATPase [General function prediction only]; Region: COG3899 234267008804 AAA ATPase domain; Region: AAA_16; pfam13191 234267008805 Predicted acetyltransferase [General function prediction only]; Region: COG5628 234267008806 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 234267008807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267008808 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 234267008809 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267008810 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267008811 Trp docking motif [polypeptide binding]; other site 234267008812 active site 234267008813 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267008814 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 234267008815 Cytochrome c; Region: Cytochrom_C; pfam00034 234267008816 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 234267008817 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 234267008818 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 234267008819 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267008820 putative catalytic residue [active] 234267008821 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267008822 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267008823 catalytic residues [active] 234267008824 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267008825 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267008826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267008827 active site 234267008828 metal binding site [ion binding]; metal-binding site 234267008829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267008830 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267008831 active site 234267008832 metal binding site [ion binding]; metal-binding site 234267008833 Protein of unknown function, DUF399; Region: DUF399; cl01139 234267008834 Domain of unknown function (DUF305); Region: DUF305; pfam03713 234267008835 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 234267008836 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267008837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267008838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267008839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267008840 binding surface 234267008841 TPR motif; other site 234267008842 CHAT domain; Region: CHAT; pfam12770 234267008843 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 234267008844 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 234267008845 active site 234267008846 catalytic residues [active] 234267008847 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267008848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008849 active site 234267008850 phosphorylation site [posttranslational modification] 234267008851 intermolecular recognition site; other site 234267008852 dimerization interface [polypeptide binding]; other site 234267008853 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267008854 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267008855 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267008856 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 234267008857 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 234267008858 dimer interface [polypeptide binding]; other site 234267008859 active site 234267008860 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234267008861 substrate binding site [chemical binding]; other site 234267008862 catalytic residue [active] 234267008863 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 234267008864 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 234267008865 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 234267008866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267008867 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267008868 DNA binding residues [nucleotide binding] 234267008869 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 234267008870 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 234267008871 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 234267008872 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 234267008873 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 234267008874 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267008875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008876 binding surface 234267008877 TPR motif; other site 234267008878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267008879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267008880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008881 binding surface 234267008882 TPR motif; other site 234267008883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267008884 binding surface 234267008885 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267008886 TPR motif; other site 234267008887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267008888 CHAT domain; Region: CHAT; pfam12770 234267008889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267008890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267008891 Putative zinc-finger; Region: zf-HC2; pfam13490 234267008892 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 234267008893 Transposase; Region: HTH_Tnp_1; pfam01527 234267008894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267008895 putative transposase OrfB; Reviewed; Region: PHA02517 234267008896 HTH-like domain; Region: HTH_21; pfam13276 234267008897 Integrase core domain; Region: rve; pfam00665 234267008898 Integrase core domain; Region: rve_3; pfam13683 234267008899 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 234267008900 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 234267008901 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 234267008902 GTPase CgtA; Reviewed; Region: obgE; PRK12299 234267008903 GTP1/OBG; Region: GTP1_OBG; pfam01018 234267008904 Obg GTPase; Region: Obg; cd01898 234267008905 G1 box; other site 234267008906 GTP/Mg2+ binding site [chemical binding]; other site 234267008907 Switch I region; other site 234267008908 G2 box; other site 234267008909 G3 box; other site 234267008910 Switch II region; other site 234267008911 G4 box; other site 234267008912 G5 box; other site 234267008913 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 234267008914 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267008915 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 234267008916 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 234267008917 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234267008918 Di-iron ligands [ion binding]; other site 234267008919 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 234267008920 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 234267008921 Sulfatase; Region: Sulfatase; cl17466 234267008922 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 234267008923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267008924 Walker A motif; other site 234267008925 ATP binding site [chemical binding]; other site 234267008926 Walker B motif; other site 234267008927 arginine finger; other site 234267008928 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 234267008929 hypothetical protein; Validated; Region: PRK00153 234267008930 recombination protein RecR; Reviewed; Region: recR; PRK00076 234267008931 RecR protein; Region: RecR; pfam02132 234267008932 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 234267008933 putative active site [active] 234267008934 putative metal-binding site [ion binding]; other site 234267008935 tetramer interface [polypeptide binding]; other site 234267008936 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267008937 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 234267008938 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 234267008939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267008940 FeS/SAM binding site; other site 234267008941 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267008942 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234267008943 substrate binding pocket [chemical binding]; other site 234267008944 membrane-bound complex binding site; other site 234267008945 hinge residues; other site 234267008946 PAS domain; Region: PAS_9; pfam13426 234267008947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267008948 putative active site [active] 234267008949 heme pocket [chemical binding]; other site 234267008950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 234267008951 dimer interface [polypeptide binding]; other site 234267008952 phosphorylation site [posttranslational modification] 234267008953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267008954 ATP binding site [chemical binding]; other site 234267008955 Mg2+ binding site [ion binding]; other site 234267008956 G-X-G motif; other site 234267008957 Response regulator receiver domain; Region: Response_reg; pfam00072 234267008958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267008959 active site 234267008960 phosphorylation site [posttranslational modification] 234267008961 intermolecular recognition site; other site 234267008962 dimerization interface [polypeptide binding]; other site 234267008963 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 234267008964 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267008965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267008966 S-adenosylmethionine binding site [chemical binding]; other site 234267008967 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267008968 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267008969 active site 234267008970 ATP binding site [chemical binding]; other site 234267008971 substrate binding site [chemical binding]; other site 234267008972 activation loop (A-loop); other site 234267008973 Beta-propeller repeat; Region: SBBP; pfam06739 234267008974 Beta-propeller repeat; Region: SBBP; pfam06739 234267008975 Beta-propeller repeat; Region: SBBP; pfam06739 234267008976 Beta-propeller repeat; Region: SBBP; pfam06739 234267008977 Beta-propeller repeat; Region: SBBP; pfam06739 234267008978 Beta-propeller repeat; Region: SBBP; pfam06739 234267008979 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267008980 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 234267008981 dimer interface [polypeptide binding]; other site 234267008982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267008983 ligand binding site [chemical binding]; other site 234267008984 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 234267008985 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 234267008986 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 234267008987 tRNA; other site 234267008988 putative tRNA binding site [nucleotide binding]; other site 234267008989 putative NADP binding site [chemical binding]; other site 234267008990 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 234267008991 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 234267008992 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 234267008993 domain interfaces; other site 234267008994 active site 234267008995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267008996 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267008997 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267008998 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 234267008999 active site 234267009000 SAM binding site [chemical binding]; other site 234267009001 homodimer interface [polypeptide binding]; other site 234267009002 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 234267009003 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234267009004 active site 234267009005 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 234267009006 AAA domain; Region: AAA_18; pfam13238 234267009007 ATP-binding site [chemical binding]; other site 234267009008 Sugar specificity; other site 234267009009 Pyrimidine base specificity; other site 234267009010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234267009011 Zn2+ binding site [ion binding]; other site 234267009012 Mg2+ binding site [ion binding]; other site 234267009013 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267009014 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 234267009015 ligand binding site [chemical binding]; other site 234267009016 flexible hinge region; other site 234267009017 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 234267009018 putative switch regulator; other site 234267009019 non-specific DNA interactions [nucleotide binding]; other site 234267009020 DNA binding site [nucleotide binding] 234267009021 sequence specific DNA binding site [nucleotide binding]; other site 234267009022 putative cAMP binding site [chemical binding]; other site 234267009023 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267009024 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267009025 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267009026 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 234267009027 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 234267009028 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 234267009029 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 234267009030 Ligand Binding Site [chemical binding]; other site 234267009031 16S rRNA methyltransferase B; Provisional; Region: PRK14901 234267009032 NusB family; Region: NusB; pfam01029 234267009033 putative RNA binding site [nucleotide binding]; other site 234267009034 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 234267009035 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 234267009036 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 234267009037 substrate binding site [chemical binding]; other site 234267009038 hexamer interface [polypeptide binding]; other site 234267009039 metal binding site [ion binding]; metal-binding site 234267009040 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 234267009041 Response regulator receiver domain; Region: Response_reg; pfam00072 234267009042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009043 active site 234267009044 phosphorylation site [posttranslational modification] 234267009045 intermolecular recognition site; other site 234267009046 dimerization interface [polypeptide binding]; other site 234267009047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 234267009048 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 234267009049 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 234267009050 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267009051 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 234267009052 YcfA-like protein; Region: YcfA; pfam07927 234267009053 thymidine kinase; Provisional; Region: PRK04296 234267009054 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009055 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267009056 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267009057 Domain of unknown function (DUF303); Region: DUF303; pfam03629 234267009058 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267009059 Serine hydrolase; Region: Ser_hydrolase; cl17834 234267009060 FlaG protein; Region: FlaG; cl00591 234267009061 VPS10 domain; Region: VPS10; smart00602 234267009062 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234267009063 FAD binding domain; Region: FAD_binding_4; pfam01565 234267009064 Berberine and berberine like; Region: BBE; pfam08031 234267009065 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267009066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009067 putative active site [active] 234267009068 heme pocket [chemical binding]; other site 234267009069 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267009070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009071 putative active site [active] 234267009072 heme pocket [chemical binding]; other site 234267009073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267009074 dimer interface [polypeptide binding]; other site 234267009075 phosphorylation site [posttranslational modification] 234267009076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009077 ATP binding site [chemical binding]; other site 234267009078 Mg2+ binding site [ion binding]; other site 234267009079 G-X-G motif; other site 234267009080 Response regulator receiver domain; Region: Response_reg; pfam00072 234267009081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009082 active site 234267009083 phosphorylation site [posttranslational modification] 234267009084 intermolecular recognition site; other site 234267009085 dimerization interface [polypeptide binding]; other site 234267009086 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 234267009087 YtxH-like protein; Region: YtxH; pfam12732 234267009088 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009089 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267009090 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 234267009091 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 234267009092 elongation factor P; Validated; Region: PRK00529 234267009093 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 234267009094 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 234267009095 RNA binding site [nucleotide binding]; other site 234267009096 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 234267009097 RNA binding site [nucleotide binding]; other site 234267009098 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267009099 Putative esterase; Region: Esterase; pfam00756 234267009100 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 234267009101 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 234267009102 Moco binding site; other site 234267009103 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 234267009104 metal coordination site [ion binding]; other site 234267009105 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 234267009106 active site 234267009107 BNR repeat-like domain; Region: BNR_2; pfam13088 234267009108 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267009109 catalytic site [active] 234267009110 Asp-box motif; other site 234267009111 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267009112 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267009113 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267009114 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009115 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009116 FtsX-like permease family; Region: FtsX; pfam02687 234267009117 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009118 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 234267009119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267009120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267009121 DNA binding site [nucleotide binding] 234267009122 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267009123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267009124 binding surface 234267009125 TPR motif; other site 234267009126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009127 binding surface 234267009128 TPR motif; other site 234267009129 Cupin domain; Region: Cupin_2; pfam07883 234267009130 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 234267009131 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234267009132 NADP binding site [chemical binding]; other site 234267009133 dimer interface [polypeptide binding]; other site 234267009134 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 234267009135 AAA ATPase domain; Region: AAA_16; pfam13191 234267009136 Walker A motif; other site 234267009137 ATP binding site [chemical binding]; other site 234267009138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267009139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267009140 DNA binding site [nucleotide binding] 234267009141 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267009142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267009143 S-adenosylmethionine binding site [chemical binding]; other site 234267009144 Putative mono-oxygenase ydhR; Region: ydhR; pfam08803 234267009145 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009146 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009147 FtsX-like permease family; Region: FtsX; pfam02687 234267009148 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009149 FtsX-like permease family; Region: FtsX; pfam02687 234267009150 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267009151 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267009152 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 234267009153 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 234267009154 Cytochrome c; Region: Cytochrom_C; pfam00034 234267009155 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267009156 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267009157 Trp docking motif [polypeptide binding]; other site 234267009158 putative active site [active] 234267009159 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267009160 Mandelate racemase (MR) catalyzes the Mg2+-dependent 1,1-proton transfer reaction that interconverts the enantiomers of mandelic acid. MR is the first enzyme in the bacterial pathway that converts mandelic acid to benzoic acid and allows this pathway to...; Region: mandelate_racemase; cd03321 234267009161 active site 234267009162 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267009163 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267009164 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267009165 active site 234267009166 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 234267009167 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 234267009168 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 234267009169 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 234267009170 catalytic residue [active] 234267009171 putative FPP diphosphate binding site; other site 234267009172 putative FPP binding hydrophobic cleft; other site 234267009173 dimer interface [polypeptide binding]; other site 234267009174 putative IPP diphosphate binding site; other site 234267009175 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009176 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009177 FtsX-like permease family; Region: FtsX; pfam02687 234267009178 FtsX-like permease family; Region: FtsX; pfam02687 234267009179 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267009180 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267009181 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267009182 DinB superfamily; Region: DinB_2; pfam12867 234267009183 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 234267009184 Response regulator receiver domain; Region: Response_reg; pfam00072 234267009185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009186 active site 234267009187 phosphorylation site [posttranslational modification] 234267009188 intermolecular recognition site; other site 234267009189 dimerization interface [polypeptide binding]; other site 234267009190 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 234267009191 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234267009192 active site 234267009193 HIGH motif; other site 234267009194 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234267009195 KMSKS motif; other site 234267009196 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234267009197 tRNA binding surface [nucleotide binding]; other site 234267009198 anticodon binding site; other site 234267009199 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 234267009200 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267009201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267009202 catalytic residue [active] 234267009203 Trehalose utilisation; Region: ThuA; pfam06283 234267009204 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267009205 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267009206 Peptidase family M48; Region: Peptidase_M48; pfam01435 234267009207 Acetokinase family; Region: Acetate_kinase; cl17229 234267009208 propionate/acetate kinase; Provisional; Region: PRK12379 234267009209 Predicted membrane protein [Function unknown]; Region: COG2259 234267009210 putative oligopeptide transporter, OPT family; Region: TIGR00733 234267009211 OPT oligopeptide transporter protein; Region: OPT; pfam03169 234267009212 Winged helix-turn helix; Region: HTH_29; pfam13551 234267009213 Homeodomain-like domain; Region: HTH_32; pfam13565 234267009214 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267009215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267009216 DNA binding residues [nucleotide binding] 234267009217 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267009218 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267009219 active site 234267009220 ATP binding site [chemical binding]; other site 234267009221 substrate binding site [chemical binding]; other site 234267009222 activation loop (A-loop); other site 234267009223 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267009224 TPR repeat; Region: TPR_11; pfam13414 234267009225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009226 TPR motif; other site 234267009227 binding surface 234267009228 TPR repeat; Region: TPR_11; pfam13414 234267009229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009230 TPR motif; other site 234267009231 binding surface 234267009232 TPR repeat; Region: TPR_11; pfam13414 234267009233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009234 binding surface 234267009235 TPR motif; other site 234267009236 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009237 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267009238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267009239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267009240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267009241 S-adenosylmethionine binding site [chemical binding]; other site 234267009242 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267009243 active site 234267009244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267009245 catalytic tetrad [active] 234267009246 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 234267009247 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 234267009248 Sel1-like repeats; Region: SEL1; smart00671 234267009249 Sel1-like repeats; Region: SEL1; smart00671 234267009250 Sel1 repeat; Region: Sel1; pfam08238 234267009251 Sel1-like repeats; Region: SEL1; smart00671 234267009252 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267009253 phosphopeptide binding site; other site 234267009254 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 234267009255 Protein phosphatase 2C; Region: PP2C; pfam00481 234267009256 active site 234267009257 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267009258 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267009259 active site 234267009260 ATP binding site [chemical binding]; other site 234267009261 substrate binding site [chemical binding]; other site 234267009262 activation loop (A-loop); other site 234267009263 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267009264 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 234267009265 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 234267009266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267009267 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 234267009268 phosphopeptide binding site; other site 234267009269 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009270 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 234267009271 GTPase RsgA; Reviewed; Region: PRK01889 234267009272 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267009273 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 234267009274 GTPase/Zn-binding domain interface [polypeptide binding]; other site 234267009275 GTP/Mg2+ binding site [chemical binding]; other site 234267009276 G4 box; other site 234267009277 G5 box; other site 234267009278 G1 box; other site 234267009279 Switch I region; other site 234267009280 G2 box; other site 234267009281 G3 box; other site 234267009282 Switch II region; other site 234267009283 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234267009284 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267009285 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267009286 Metal-binding active site; metal-binding site 234267009287 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009289 FtsX-like permease family; Region: FtsX; pfam02687 234267009290 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009291 FtsX-like permease family; Region: FtsX; pfam02687 234267009292 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234267009293 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 234267009294 dimer interface [polypeptide binding]; other site 234267009295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267009296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267009297 dimer interface [polypeptide binding]; other site 234267009298 phosphorylation site [posttranslational modification] 234267009299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009300 ATP binding site [chemical binding]; other site 234267009301 Mg2+ binding site [ion binding]; other site 234267009302 G-X-G motif; other site 234267009303 Response regulator receiver domain; Region: Response_reg; pfam00072 234267009304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009305 active site 234267009306 phosphorylation site [posttranslational modification] 234267009307 intermolecular recognition site; other site 234267009308 dimerization interface [polypeptide binding]; other site 234267009309 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267009310 DinB superfamily; Region: DinB_2; pfam12867 234267009311 DinB family; Region: DinB; cl17821 234267009312 NHL repeat; Region: NHL; pfam01436 234267009313 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 234267009314 NHL repeat; Region: NHL; pfam01436 234267009315 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267009316 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267009317 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267009318 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267009319 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267009320 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267009321 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267009322 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009323 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009324 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009325 FtsX-like permease family; Region: FtsX; pfam02687 234267009326 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 234267009327 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 234267009328 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 234267009329 active site 1 [active] 234267009330 dimer interface [polypeptide binding]; other site 234267009331 hexamer interface [polypeptide binding]; other site 234267009332 active site 2 [active] 234267009333 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 234267009334 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 234267009335 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267009336 catalytic Zn binding site [ion binding]; other site 234267009337 NAD(P) binding site [chemical binding]; other site 234267009338 structural Zn binding site [ion binding]; other site 234267009339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267009340 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267009341 active site 234267009342 catalytic tetrad [active] 234267009343 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 234267009344 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 234267009345 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234267009346 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 234267009347 Putative transposase; Region: Y2_Tnp; pfam04986 234267009348 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 234267009349 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 234267009350 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 234267009351 Int/Topo IB signature motif; other site 234267009352 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 234267009353 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 234267009354 Int/Topo IB signature motif; other site 234267009355 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267009356 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 234267009357 Int/Topo IB signature motif; other site 234267009358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267009359 active site 234267009360 Int/Topo IB signature motif; other site 234267009361 DNA binding site [nucleotide binding] 234267009362 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 234267009363 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 234267009364 putative active site [active] 234267009365 putative NTP binding site [chemical binding]; other site 234267009366 putative nucleic acid binding site [nucleotide binding]; other site 234267009367 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 234267009368 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267009369 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009370 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009371 FtsX-like permease family; Region: FtsX; pfam02687 234267009372 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009373 FtsX-like permease family; Region: FtsX; pfam02687 234267009374 PAS domain S-box; Region: sensory_box; TIGR00229 234267009375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009376 putative active site [active] 234267009377 heme pocket [chemical binding]; other site 234267009378 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 234267009379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267009380 dimer interface [polypeptide binding]; other site 234267009381 phosphorylation site [posttranslational modification] 234267009382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009383 ATP binding site [chemical binding]; other site 234267009384 Mg2+ binding site [ion binding]; other site 234267009385 G-X-G motif; other site 234267009386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267009387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009388 active site 234267009389 phosphorylation site [posttranslational modification] 234267009390 intermolecular recognition site; other site 234267009391 dimerization interface [polypeptide binding]; other site 234267009392 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 234267009393 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 234267009394 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 234267009395 Hemerythrin-like domain; Region: Hr-like; cd12108 234267009396 Fe binding site [ion binding]; other site 234267009397 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267009398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009399 TPR repeat; Region: TPR_11; pfam13414 234267009400 binding surface 234267009401 TPR motif; other site 234267009402 TPR repeat; Region: TPR_11; pfam13414 234267009403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009404 binding surface 234267009405 TPR motif; other site 234267009406 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009407 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009409 TPR motif; other site 234267009410 binding surface 234267009411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009412 binding surface 234267009413 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009414 TPR motif; other site 234267009415 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267009416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009417 TPR motif; other site 234267009418 binding surface 234267009419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009420 binding surface 234267009421 TPR motif; other site 234267009422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009423 binding surface 234267009424 TPR motif; other site 234267009425 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267009426 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267009427 active site 234267009428 ATP binding site [chemical binding]; other site 234267009429 substrate binding site [chemical binding]; other site 234267009430 activation loop (A-loop); other site 234267009431 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 234267009432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267009433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267009434 methionine synthase; Provisional; Region: PRK01207 234267009435 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 234267009436 substrate binding site [chemical binding]; other site 234267009437 THF binding site; other site 234267009438 zinc-binding site [ion binding]; other site 234267009439 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267009440 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267009441 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267009442 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267009443 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267009444 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 234267009445 putative dimer interface [polypeptide binding]; other site 234267009446 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267009447 Phosphotransferase enzyme family; Region: APH; pfam01636 234267009448 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267009449 active site 234267009450 substrate binding site [chemical binding]; other site 234267009451 ATP binding site [chemical binding]; other site 234267009452 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 234267009453 putative aminotransferase; Provisional; Region: PRK09105 234267009454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267009455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267009456 homodimer interface [polypeptide binding]; other site 234267009457 catalytic residue [active] 234267009458 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234267009459 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234267009460 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234267009461 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009462 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267009463 Purine nucleoside permease (NUP); Region: NUP; pfam06516 234267009464 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267009465 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267009466 active site pocket [active] 234267009467 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 234267009468 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 234267009469 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 234267009470 mannonate dehydratase; Region: uxuA; TIGR00695 234267009471 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 234267009472 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 234267009473 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 234267009474 putative metal binding site [ion binding]; other site 234267009475 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267009476 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 234267009477 oligomeric interface; other site 234267009478 homodimer interface [polypeptide binding]; other site 234267009479 putative active site [active] 234267009480 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 234267009481 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 234267009482 substrate binding pocket [chemical binding]; other site 234267009483 chain length determination region; other site 234267009484 substrate-Mg2+ binding site; other site 234267009485 catalytic residues [active] 234267009486 aspartate-rich region 1; other site 234267009487 active site lid residues [active] 234267009488 aspartate-rich region 2; other site 234267009489 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 234267009490 active site 234267009491 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 234267009492 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 234267009493 active site 234267009494 HIGH motif; other site 234267009495 KMSKS motif; other site 234267009496 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 234267009497 tRNA binding surface [nucleotide binding]; other site 234267009498 anticodon binding site; other site 234267009499 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 234267009500 dimer interface [polypeptide binding]; other site 234267009501 putative tRNA-binding site [nucleotide binding]; other site 234267009502 hypothetical protein; Provisional; Region: PRK04194 234267009503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009504 PAS domain; Region: PAS_9; pfam13426 234267009505 putative active site [active] 234267009506 heme pocket [chemical binding]; other site 234267009507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267009508 dimer interface [polypeptide binding]; other site 234267009509 phosphorylation site [posttranslational modification] 234267009510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009511 ATP binding site [chemical binding]; other site 234267009512 Mg2+ binding site [ion binding]; other site 234267009513 G-X-G motif; other site 234267009514 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267009516 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267009517 active site 234267009518 ATP binding site [chemical binding]; other site 234267009519 substrate binding site [chemical binding]; other site 234267009520 activation loop (A-loop); other site 234267009521 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267009522 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267009523 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009524 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267009525 PAS fold; Region: PAS_4; pfam08448 234267009526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009527 putative active site [active] 234267009528 heme pocket [chemical binding]; other site 234267009529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009530 PAS fold; Region: PAS_3; pfam08447 234267009531 putative active site [active] 234267009532 heme pocket [chemical binding]; other site 234267009533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009534 PAS fold; Region: PAS_3; pfam08447 234267009535 putative active site [active] 234267009536 heme pocket [chemical binding]; other site 234267009537 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267009538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267009539 putative active site [active] 234267009540 heme pocket [chemical binding]; other site 234267009541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009542 ATP binding site [chemical binding]; other site 234267009543 Mg2+ binding site [ion binding]; other site 234267009544 G-X-G motif; other site 234267009545 Response regulator receiver domain; Region: Response_reg; pfam00072 234267009546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009547 active site 234267009548 phosphorylation site [posttranslational modification] 234267009549 intermolecular recognition site; other site 234267009550 dimerization interface [polypeptide binding]; other site 234267009551 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 234267009552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267009553 putative DNA binding site [nucleotide binding]; other site 234267009554 dimerization interface [polypeptide binding]; other site 234267009555 putative Zn2+ binding site [ion binding]; other site 234267009556 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 234267009557 putative hydrophobic ligand binding site [chemical binding]; other site 234267009558 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009559 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267009560 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267009561 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267009562 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267009563 metal ion-dependent adhesion site (MIDAS); other site 234267009564 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 234267009565 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267009566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267009567 protein binding site [polypeptide binding]; other site 234267009568 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267009569 protein binding site [polypeptide binding]; other site 234267009570 Domain of unknown function (DUF309); Region: DUF309; pfam03745 234267009571 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 234267009572 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 234267009573 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 234267009574 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 234267009575 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 234267009576 ligand binding site [chemical binding]; other site 234267009577 homodimer interface [polypeptide binding]; other site 234267009578 NAD(P) binding site [chemical binding]; other site 234267009579 trimer interface B [polypeptide binding]; other site 234267009580 trimer interface A [polypeptide binding]; other site 234267009581 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 234267009582 active site 234267009583 multimer interface [polypeptide binding]; other site 234267009584 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 234267009585 CoA binding domain; Region: CoA_binding; smart00881 234267009586 CoA-ligase; Region: Ligase_CoA; pfam00549 234267009587 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 234267009588 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 234267009589 CoA-ligase; Region: Ligase_CoA; pfam00549 234267009590 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 234267009591 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 234267009592 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 234267009593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 234267009594 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 234267009595 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267009596 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267009597 metal ion-dependent adhesion site (MIDAS); other site 234267009598 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267009599 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267009600 ligand binding site [chemical binding]; other site 234267009601 Uncharacterized conserved protein [Function unknown]; Region: COG5361 234267009602 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 234267009603 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 234267009604 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267009605 HEAT repeats; Region: HEAT_2; pfam13646 234267009606 TPR repeat; Region: TPR_11; pfam13414 234267009607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009608 binding surface 234267009609 TPR motif; other site 234267009610 TPR repeat; Region: TPR_11; pfam13414 234267009611 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267009612 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 234267009613 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267009614 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267009615 metal ion-dependent adhesion site (MIDAS); other site 234267009616 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009617 TPR repeat; Region: TPR_11; pfam13414 234267009618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009619 binding surface 234267009620 TPR motif; other site 234267009621 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 234267009622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267009623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234267009624 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 234267009625 short chain dehydrogenase; Provisional; Region: PRK06482 234267009626 NADP binding site [chemical binding]; other site 234267009627 active site 234267009628 steroid binding site; other site 234267009629 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267009630 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267009631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267009632 active site 234267009633 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267009634 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267009635 metal ion-dependent adhesion site (MIDAS); other site 234267009636 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267009637 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267009638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267009639 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267009640 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 234267009641 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 234267009642 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267009643 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267009644 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267009645 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267009646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267009647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267009648 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267009649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009650 active site 234267009651 phosphorylation site [posttranslational modification] 234267009652 intermolecular recognition site; other site 234267009653 dimerization interface [polypeptide binding]; other site 234267009654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267009655 Walker A motif; other site 234267009656 ATP binding site [chemical binding]; other site 234267009657 Walker B motif; other site 234267009658 arginine finger; other site 234267009659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267009660 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 234267009661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267009662 dimerization interface [polypeptide binding]; other site 234267009663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267009664 dimer interface [polypeptide binding]; other site 234267009665 phosphorylation site [posttranslational modification] 234267009666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009667 ATP binding site [chemical binding]; other site 234267009668 Mg2+ binding site [ion binding]; other site 234267009669 G-X-G motif; other site 234267009670 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267009671 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 234267009672 dimer interface [polypeptide binding]; other site 234267009673 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 234267009674 putative CheW interface [polypeptide binding]; other site 234267009675 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 234267009676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234267009677 active site 234267009678 comF family protein; Region: comF; TIGR00201 234267009679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267009680 active site 234267009681 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267009682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267009683 metal ion-dependent adhesion site (MIDAS); other site 234267009684 Bacterial SH3 domain; Region: SH3_4; pfam06347 234267009685 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234267009686 NlpC/P60 family; Region: NLPC_P60; pfam00877 234267009687 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 234267009688 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 234267009689 active site 234267009690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267009691 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 234267009692 N- and C-terminal domain interface [polypeptide binding]; other site 234267009693 active site 234267009694 putative catalytic site [active] 234267009695 metal binding site [ion binding]; metal-binding site 234267009696 ATP binding site [chemical binding]; other site 234267009697 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 234267009698 carbohydrate binding site [chemical binding]; other site 234267009699 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009700 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009701 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009702 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009703 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 234267009704 allophanate hydrolase; Provisional; Region: PRK08186 234267009705 Amidase; Region: Amidase; cl11426 234267009706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234267009707 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267009708 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267009709 Flagellin N-methylase; Region: FliB; pfam03692 234267009710 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267009711 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234267009712 phosphopeptide binding site; other site 234267009713 GAF domain; Region: GAF_2; pfam13185 234267009714 GAF domain; Region: GAF; pfam01590 234267009715 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267009716 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267009717 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 234267009718 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 234267009719 putative heme binding pocket [chemical binding]; other site 234267009720 Hemerythrin-like domain; Region: Hr-like; cd12108 234267009721 Fe binding site [ion binding]; other site 234267009722 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 234267009723 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 234267009724 putative homodimer interface [polypeptide binding]; other site 234267009725 putative DNA binding site [nucleotide binding]; other site 234267009726 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267009727 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267009728 active site pocket [active] 234267009729 Predicted esterase [General function prediction only]; Region: COG0400 234267009730 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 234267009731 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 234267009732 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267009733 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267009734 active site 234267009735 ATP binding site [chemical binding]; other site 234267009736 substrate binding site [chemical binding]; other site 234267009737 activation loop (A-loop); other site 234267009738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267009739 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267009740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267009741 DNA binding residues [nucleotide binding] 234267009742 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267009743 VPS10 domain; Region: VPS10; smart00602 234267009744 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 234267009745 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234267009746 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267009747 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267009748 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267009749 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234267009750 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267009751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267009752 catalytic residue [active] 234267009753 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 234267009754 active site 234267009755 catalytic residues [active] 234267009756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009757 TPR motif; other site 234267009758 binding surface 234267009759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267009760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009761 binding surface 234267009762 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267009763 TPR motif; other site 234267009764 CHAT domain; Region: CHAT; pfam12770 234267009765 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267009766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267009767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267009768 DNA binding residues [nucleotide binding] 234267009769 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234267009770 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 234267009771 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234267009772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267009773 dimer interface [polypeptide binding]; other site 234267009774 conserved gate region; other site 234267009775 putative PBP binding loops; other site 234267009776 ABC-ATPase subunit interface; other site 234267009777 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234267009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267009779 dimer interface [polypeptide binding]; other site 234267009780 conserved gate region; other site 234267009781 putative PBP binding loops; other site 234267009782 ABC-ATPase subunit interface; other site 234267009783 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 234267009784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234267009785 Walker A/P-loop; other site 234267009786 ATP binding site [chemical binding]; other site 234267009787 Q-loop/lid; other site 234267009788 ABC transporter signature motif; other site 234267009789 Walker B; other site 234267009790 D-loop; other site 234267009791 H-loop/switch region; other site 234267009792 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234267009793 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234267009794 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267009795 Walker A/P-loop; other site 234267009796 ATP binding site [chemical binding]; other site 234267009797 Q-loop/lid; other site 234267009798 ABC transporter signature motif; other site 234267009799 Walker B; other site 234267009800 D-loop; other site 234267009801 H-loop/switch region; other site 234267009802 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 234267009803 nucleotide binding site/active site [active] 234267009804 HIT family signature motif; other site 234267009805 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267009806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267009807 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 234267009808 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 234267009809 putative DNA binding site [nucleotide binding]; other site 234267009810 catalytic residue [active] 234267009811 putative H2TH interface [polypeptide binding]; other site 234267009812 putative catalytic residues [active] 234267009813 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234267009814 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234267009815 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 234267009816 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 234267009817 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 234267009818 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 234267009819 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 234267009820 active site 234267009821 substrate-binding site [chemical binding]; other site 234267009822 metal-binding site [ion binding] 234267009823 ATP binding site [chemical binding]; other site 234267009824 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009826 FtsX-like permease family; Region: FtsX; pfam02687 234267009827 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009828 FtsX-like permease family; Region: FtsX; pfam02687 234267009829 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 234267009830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267009831 S-adenosylmethionine binding site [chemical binding]; other site 234267009832 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267009833 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267009834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 234267009835 MOSC domain; Region: MOSC; pfam03473 234267009836 3-alpha domain; Region: 3-alpha; pfam03475 234267009837 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 234267009838 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 234267009839 FAD binding pocket [chemical binding]; other site 234267009840 FAD binding motif [chemical binding]; other site 234267009841 phosphate binding motif [ion binding]; other site 234267009842 beta-alpha-beta structure motif; other site 234267009843 NAD binding pocket [chemical binding]; other site 234267009844 Heme binding pocket [chemical binding]; other site 234267009845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267009846 catalytic loop [active] 234267009847 iron binding site [ion binding]; other site 234267009848 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234267009849 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267009850 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267009851 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267009852 Family description; Region: VCBS; pfam13517 234267009853 Family description; Region: VCBS; pfam13517 234267009854 Family description; Region: VCBS; pfam13517 234267009855 Family description; Region: VCBS; pfam13517 234267009856 Family description; Region: VCBS; pfam13517 234267009857 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267009858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267009859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267009860 active site 234267009861 phosphorylation site [posttranslational modification] 234267009862 intermolecular recognition site; other site 234267009863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267009864 DNA binding residues [nucleotide binding] 234267009865 dimerization interface [polypeptide binding]; other site 234267009866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267009867 Histidine kinase; Region: HisKA_3; pfam07730 234267009868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267009869 ATP binding site [chemical binding]; other site 234267009870 Mg2+ binding site [ion binding]; other site 234267009871 G-X-G motif; other site 234267009872 TPR repeat; Region: TPR_11; pfam13414 234267009873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009874 binding surface 234267009875 TPR motif; other site 234267009876 TPR repeat; Region: TPR_11; pfam13414 234267009877 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009878 Family description; Region: VCBS; pfam13517 234267009879 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267009880 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267009881 TPR repeat; Region: TPR_11; pfam13414 234267009882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009883 binding surface 234267009884 TPR motif; other site 234267009885 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009886 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009887 Family description; Region: VCBS; pfam13517 234267009888 Family description; Region: VCBS; pfam13517 234267009889 Family description; Region: VCBS; pfam13517 234267009890 Family description; Region: VCBS; pfam13517 234267009891 Family description; Region: VCBS; pfam13517 234267009892 Family description; Region: VCBS; pfam13517 234267009893 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267009894 Uncharacterized conserved protein [Function unknown]; Region: COG1359 234267009895 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267009896 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267009897 catalytic residues [active] 234267009898 Carbohydrate-binding protein of the ER; Region: Malectin_like; pfam12819 234267009899 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267009900 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267009901 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267009902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009903 binding surface 234267009904 TPR repeat; Region: TPR_11; pfam13414 234267009905 TPR motif; other site 234267009906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009907 TPR motif; other site 234267009908 binding surface 234267009909 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267009910 TPR repeat; Region: TPR_11; pfam13414 234267009911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009912 TPR motif; other site 234267009913 binding surface 234267009914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009915 TPR motif; other site 234267009916 binding surface 234267009917 TPR repeat; Region: TPR_11; pfam13414 234267009918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009919 binding surface 234267009920 TPR motif; other site 234267009921 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267009922 Iodothyronine deiodinase; Region: T4_deiodinase; pfam00837 234267009923 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267009924 TPR repeat; Region: TPR_11; pfam13414 234267009925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009926 binding surface 234267009927 TPR motif; other site 234267009928 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267009929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009930 binding surface 234267009931 TPR motif; other site 234267009932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267009933 binding surface 234267009934 TPR motif; other site 234267009935 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267009936 Family description; Region: VCBS; pfam13517 234267009937 Family description; Region: VCBS; pfam13517 234267009938 Family description; Region: VCBS; pfam13517 234267009939 Family description; Region: VCBS; pfam13517 234267009940 Family description; Region: VCBS; pfam13517 234267009941 Family description; Region: VCBS; pfam13517 234267009942 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267009943 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267009944 Amidase; Region: Amidase; cl11426 234267009945 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 234267009946 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 234267009947 Beta-propeller repeat; Region: SBBP; pfam06739 234267009948 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 234267009949 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 234267009950 Rrf2 family protein; Region: rrf2_super; TIGR00738 234267009951 Transcriptional regulator; Region: Rrf2; pfam02082 234267009952 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 234267009953 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 234267009954 iron-sulfur cluster [ion binding]; other site 234267009955 [2Fe-2S] cluster binding site [ion binding]; other site 234267009956 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 234267009957 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 234267009958 heme bH binding site [chemical binding]; other site 234267009959 intrachain domain interface; other site 234267009960 Qi binding site; other site 234267009961 heme bL binding site [chemical binding]; other site 234267009962 interchain domain interface [polypeptide binding]; other site 234267009963 Qo binding site; other site 234267009964 Cytochrome c; Region: Cytochrom_C; pfam00034 234267009965 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 234267009966 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267009967 Cytochrome c; Region: Cytochrom_C; cl11414 234267009968 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 234267009969 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 234267009970 Low-spin heme binding site [chemical binding]; other site 234267009971 D-pathway; other site 234267009972 Putative water exit pathway; other site 234267009973 Binuclear center (active site) [active] 234267009974 K-pathway; other site 234267009975 Putative proton exit pathway; other site 234267009976 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 234267009977 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 234267009978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267009979 Family description; Region: DsbD_2; pfam13386 234267009980 4Fe-4S binding domain; Region: Fer4_5; pfam12801 234267009981 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 234267009982 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267009983 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 234267009984 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 234267009985 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 234267009986 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 234267009987 metal-binding site [ion binding] 234267009988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234267009989 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267009990 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009991 FtsX-like permease family; Region: FtsX; pfam02687 234267009992 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267009993 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267009994 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 234267009995 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267009996 metal binding site [ion binding]; metal-binding site 234267009997 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 234267009998 Cytochrome c; Region: Cytochrom_C; pfam00034 234267009999 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267010000 putative active site [active] 234267010001 Zn binding site [ion binding]; other site 234267010002 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 234267010003 apolar tunnel; other site 234267010004 heme binding site [chemical binding]; other site 234267010005 dimerization interface [polypeptide binding]; other site 234267010006 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267010007 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267010008 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234267010009 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267010010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267010011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267010012 DNA binding residues [nucleotide binding] 234267010013 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 234267010014 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010015 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 234267010016 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 234267010017 putative active site pocket [active] 234267010018 putative metal binding site [ion binding]; other site 234267010019 Protein of unknown function (DUF419); Region: DUF419; pfam04237 234267010020 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267010021 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267010022 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010024 FtsX-like permease family; Region: FtsX; pfam02687 234267010025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010026 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267010027 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 234267010028 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234267010029 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234267010030 shikimate binding site; other site 234267010031 NAD(P) binding site [chemical binding]; other site 234267010032 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267010033 Asp-box motif; other site 234267010034 BNR repeat-like domain; Region: BNR_2; pfam13088 234267010035 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 234267010036 putative active site [active] 234267010037 Zn binding site [ion binding]; other site 234267010038 Methane oxygenase PmoA; Region: PmoA; pfam14100 234267010039 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267010040 Domain of unknown function DUF11; Region: DUF11; cl17728 234267010041 Putative Ig domain; Region: He_PIG; pfam05345 234267010042 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 234267010043 proline aminopeptidase P II; Provisional; Region: PRK10879 234267010044 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 234267010045 active site 234267010046 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 234267010047 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 234267010048 Glutamate binding site [chemical binding]; other site 234267010049 homodimer interface [polypeptide binding]; other site 234267010050 NAD binding site [chemical binding]; other site 234267010051 catalytic residues [active] 234267010052 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234267010053 Ligand Binding Site [chemical binding]; other site 234267010054 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234267010055 Ligand Binding Site [chemical binding]; other site 234267010056 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 234267010057 putative tRNA-binding site [nucleotide binding]; other site 234267010058 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 234267010059 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010060 active site 234267010061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010062 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234267010063 MarR family; Region: MarR_2; pfam12802 234267010064 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 234267010065 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234267010066 dimer interface [polypeptide binding]; other site 234267010067 active site 234267010068 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 234267010069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267010070 FeS/SAM binding site; other site 234267010071 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 234267010072 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 234267010073 putative hydrophobic ligand binding site [chemical binding]; other site 234267010074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267010075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267010076 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267010077 M28 Zn-Peptidases; Region: M28_like_4; cd08015 234267010078 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267010079 metal binding site [ion binding]; metal-binding site 234267010080 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 234267010081 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 234267010082 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267010083 substrate binding site [chemical binding]; other site 234267010084 ATP binding site [chemical binding]; other site 234267010085 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 234267010086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267010087 motif II; other site 234267010088 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267010089 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267010090 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010091 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010092 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010093 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267010094 active site 234267010095 metal binding site [ion binding]; metal-binding site 234267010096 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267010097 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 234267010098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234267010099 ATP-dependent DNA ligase; Validated; Region: PRK09247 234267010100 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 234267010101 active site 234267010102 DNA binding site [nucleotide binding] 234267010103 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 234267010104 DNA binding site [nucleotide binding] 234267010105 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 234267010106 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010107 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267010108 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 234267010109 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234267010110 Peptidase family M23; Region: Peptidase_M23; pfam01551 234267010111 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234267010112 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267010113 Predicted membrane protein [Function unknown]; Region: COG2246 234267010114 GtrA-like protein; Region: GtrA; pfam04138 234267010115 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 234267010116 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 234267010117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010118 binding surface 234267010119 TPR motif; other site 234267010120 putative transposase OrfB; Reviewed; Region: PHA02517 234267010121 HTH-like domain; Region: HTH_21; pfam13276 234267010122 Integrase core domain; Region: rve; pfam00665 234267010123 Integrase core domain; Region: rve_3; pfam13683 234267010124 Transposase; Region: HTH_Tnp_1; pfam01527 234267010125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267010126 epoxyqueuosine reductase; Region: TIGR00276 234267010127 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 234267010128 MutS domain III; Region: MutS_III; pfam05192 234267010129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267010130 Walker A/P-loop; other site 234267010131 ATP binding site [chemical binding]; other site 234267010132 Q-loop/lid; other site 234267010133 ABC transporter signature motif; other site 234267010134 Walker B; other site 234267010135 D-loop; other site 234267010136 H-loop/switch region; other site 234267010137 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 234267010138 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267010139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267010140 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010141 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267010142 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234267010143 active site residue [active] 234267010144 Beta-propeller repeat; Region: SBBP; pfam06739 234267010145 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 234267010146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 234267010147 Coenzyme A binding pocket [chemical binding]; other site 234267010148 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 234267010149 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 234267010150 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 234267010151 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 234267010152 trimer interface [polypeptide binding]; other site 234267010153 active site 234267010154 UDP-GlcNAc binding site [chemical binding]; other site 234267010155 lipid binding site [chemical binding]; lipid-binding site 234267010156 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010157 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267010158 Putative cyclase; Region: Cyclase; pfam04199 234267010159 OsmC-like protein; Region: OsmC; pfam02566 234267010160 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267010161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010162 active site 234267010163 ATP binding site [chemical binding]; other site 234267010164 substrate binding site [chemical binding]; other site 234267010165 activation loop (A-loop); other site 234267010166 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010167 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267010168 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010169 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267010170 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010171 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267010172 DinB family; Region: DinB; cl17821 234267010173 DinB superfamily; Region: DinB_2; pfam12867 234267010174 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 234267010175 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267010176 catalytic triad [active] 234267010177 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267010178 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 234267010179 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 234267010180 dimer interface [polypeptide binding]; other site 234267010181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267010182 ligand binding site [chemical binding]; other site 234267010183 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 234267010184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267010185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267010186 DNA binding residues [nucleotide binding] 234267010187 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010188 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010189 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010190 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267010191 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267010192 AMP-binding domain protein; Validated; Region: PRK08315 234267010193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234267010194 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234267010195 acyl-activating enzyme (AAE) consensus motif; other site 234267010196 acyl-activating enzyme (AAE) consensus motif; other site 234267010197 putative AMP binding site [chemical binding]; other site 234267010198 putative active site [active] 234267010199 putative CoA binding site [chemical binding]; other site 234267010200 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267010201 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267010202 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267010203 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 234267010204 putative active site [active] 234267010205 putative CoA binding site [chemical binding]; other site 234267010206 nudix motif; other site 234267010207 metal binding site [ion binding]; metal-binding site 234267010208 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 234267010209 aminotransferase; Validated; Region: PRK07777 234267010210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267010211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267010212 homodimer interface [polypeptide binding]; other site 234267010213 catalytic residue [active] 234267010214 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 234267010215 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234267010216 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234267010217 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267010218 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267010219 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010220 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267010221 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 234267010222 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 234267010223 active site 234267010224 putative substrate binding pocket [chemical binding]; other site 234267010225 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010226 TPR repeat; Region: TPR_11; pfam13414 234267010227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010228 binding surface 234267010229 TPR motif; other site 234267010230 TPR repeat; Region: TPR_11; pfam13414 234267010231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010232 binding surface 234267010233 TPR motif; other site 234267010234 TPR repeat; Region: TPR_11; pfam13414 234267010235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010236 binding surface 234267010237 TPR motif; other site 234267010238 TPR repeat; Region: TPR_11; pfam13414 234267010239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010240 binding surface 234267010241 TPR repeat; Region: TPR_11; pfam13414 234267010242 TPR motif; other site 234267010243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010244 TPR motif; other site 234267010245 TPR repeat; Region: TPR_11; pfam13414 234267010246 binding surface 234267010247 TPR repeat; Region: TPR_11; pfam13414 234267010248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010249 binding surface 234267010250 TPR motif; other site 234267010251 TPR repeat; Region: TPR_11; pfam13414 234267010252 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267010253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234267010254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267010255 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 234267010256 classical (c) SDRs; Region: SDR_c; cd05233 234267010257 NAD(P) binding site [chemical binding]; other site 234267010258 active site 234267010259 TIGR03118 family protein; Region: PEPCTERM_chp_1 234267010260 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267010261 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267010262 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 234267010263 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 234267010264 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 234267010265 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 234267010266 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 234267010267 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 234267010268 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267010269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267010270 dimerization interface [polypeptide binding]; other site 234267010271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267010272 dimer interface [polypeptide binding]; other site 234267010273 phosphorylation site [posttranslational modification] 234267010274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267010275 ATP binding site [chemical binding]; other site 234267010276 Mg2+ binding site [ion binding]; other site 234267010277 G-X-G motif; other site 234267010278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267010279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267010280 active site 234267010281 phosphorylation site [posttranslational modification] 234267010282 intermolecular recognition site; other site 234267010283 dimerization interface [polypeptide binding]; other site 234267010284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267010285 DNA binding site [nucleotide binding] 234267010286 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010287 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010288 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267010289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267010290 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010292 FtsX-like permease family; Region: FtsX; pfam02687 234267010293 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010294 FtsX-like permease family; Region: FtsX; pfam02687 234267010295 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267010296 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010297 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 234267010298 Sel1-like repeats; Region: SEL1; smart00671 234267010299 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267010300 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 234267010301 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234267010302 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267010303 inhibitor site; inhibition site 234267010304 active site 234267010305 dimer interface [polypeptide binding]; other site 234267010306 catalytic residue [active] 234267010307 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 234267010308 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 234267010309 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267010310 catalytic loop [active] 234267010311 iron binding site [ion binding]; other site 234267010312 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267010313 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 234267010314 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 234267010315 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267010316 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267010317 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267010318 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267010319 putative active site [active] 234267010320 Zn binding site [ion binding]; other site 234267010321 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 234267010322 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267010323 short chain dehydrogenase; Provisional; Region: PRK12828 234267010324 classical (c) SDRs; Region: SDR_c; cd05233 234267010325 NAD(P) binding site [chemical binding]; other site 234267010326 active site 234267010327 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 234267010328 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 234267010329 Cl- selectivity filter; other site 234267010330 Cl- binding residues [ion binding]; other site 234267010331 pore gating glutamate residue; other site 234267010332 dimer interface [polypeptide binding]; other site 234267010333 FOG: CBS domain [General function prediction only]; Region: COG0517 234267010334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 234267010335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010336 binding surface 234267010337 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267010338 TPR motif; other site 234267010339 Trehalose utilisation; Region: ThuA; pfam06283 234267010340 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267010341 polyphosphate kinase; Provisional; Region: PRK05443 234267010342 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 234267010343 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 234267010344 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 234267010345 putative domain interface [polypeptide binding]; other site 234267010346 putative active site [active] 234267010347 catalytic site [active] 234267010348 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 234267010349 putative domain interface [polypeptide binding]; other site 234267010350 putative active site [active] 234267010351 catalytic site [active] 234267010352 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267010353 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 234267010354 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267010355 active site 234267010356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267010358 active site 234267010359 ATP binding site [chemical binding]; other site 234267010360 substrate binding site [chemical binding]; other site 234267010361 activation loop (A-loop); other site 234267010362 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 234267010363 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 234267010364 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010366 FtsX-like permease family; Region: FtsX; pfam02687 234267010367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010368 FtsX-like permease family; Region: FtsX; pfam02687 234267010369 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 234267010370 Rrf2 family protein; Region: rrf2_super; TIGR00738 234267010371 Transcriptional regulator; Region: Rrf2; pfam02082 234267010372 Protein of unknown function (DUF664); Region: DUF664; pfam04978 234267010373 DinB superfamily; Region: DinB_2; pfam12867 234267010374 Dienelactone hydrolase family; Region: DLH; pfam01738 234267010375 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267010376 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267010377 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267010378 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 234267010379 selenocysteine synthase; Provisional; Region: PRK04311 234267010380 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 234267010381 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267010382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267010383 catalytic residue [active] 234267010384 translation elongation factor P; Region: efp; TIGR00038 234267010385 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 234267010386 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 234267010387 RNA binding site [nucleotide binding]; other site 234267010388 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 234267010389 RNA binding site [nucleotide binding]; other site 234267010390 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267010391 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267010392 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267010393 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 234267010394 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010395 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010396 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010397 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 234267010398 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267010399 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010400 active site 234267010401 ATP binding site [chemical binding]; other site 234267010402 substrate binding site [chemical binding]; other site 234267010403 activation loop (A-loop); other site 234267010404 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267010405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010406 TPR repeat; Region: TPR_11; pfam13414 234267010407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010408 TPR motif; other site 234267010409 Domain of unknown function DUF302; Region: DUF302; pfam03625 234267010410 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 234267010411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267010412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267010413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 234267010414 DinB superfamily; Region: DinB_2; pfam12867 234267010415 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 234267010416 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234267010417 TPP-binding site [chemical binding]; other site 234267010418 tetramer interface [polypeptide binding]; other site 234267010419 heterodimer interface [polypeptide binding]; other site 234267010420 phosphorylation loop region [posttranslational modification] 234267010421 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234267010422 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234267010423 alpha subunit interface [polypeptide binding]; other site 234267010424 TPP binding site [chemical binding]; other site 234267010425 heterodimer interface [polypeptide binding]; other site 234267010426 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267010427 EamA-like transporter family; Region: EamA; pfam00892 234267010428 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 234267010429 EamA-like transporter family; Region: EamA; pfam00892 234267010430 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010431 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 234267010432 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 234267010433 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267010434 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267010435 metal ion-dependent adhesion site (MIDAS); other site 234267010436 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267010437 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010438 active site 234267010439 ATP binding site [chemical binding]; other site 234267010440 substrate binding site [chemical binding]; other site 234267010441 activation loop (A-loop); other site 234267010442 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267010443 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010444 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010445 Lipase (class 2); Region: Lipase_2; pfam01674 234267010446 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267010447 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010448 active site 234267010449 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 234267010450 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010451 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 234267010452 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 234267010453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267010454 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267010455 YCII-related domain; Region: YCII; cl00999 234267010456 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 234267010457 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 234267010458 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267010459 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267010460 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267010461 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010462 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267010463 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234267010464 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267010465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267010466 catalytic residue [active] 234267010467 Peptidase family M48; Region: Peptidase_M48; cl12018 234267010468 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 234267010469 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010470 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010471 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267010472 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 234267010473 protein binding site [polypeptide binding]; other site 234267010474 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 234267010475 Domain interface; other site 234267010476 Peptide binding site; other site 234267010477 Active site tetrad [active] 234267010478 CsbD-like; Region: CsbD; cl17424 234267010479 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 234267010480 homodimer interface [polypeptide binding]; other site 234267010481 homotetramer interface [polypeptide binding]; other site 234267010482 active site pocket [active] 234267010483 cleavage site 234267010484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234267010485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 234267010486 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 234267010487 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267010488 M28 Zn-Peptidases; Region: M28_like_4; cd08015 234267010489 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267010490 metal binding site [ion binding]; metal-binding site 234267010491 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010492 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267010493 active site 234267010494 ATP binding site [chemical binding]; other site 234267010495 substrate binding site [chemical binding]; other site 234267010496 activation loop (A-loop); other site 234267010497 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267010498 Region of unknown function (DUF2417); Region: DUF2417; pfam10329 234267010499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267010500 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267010501 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267010502 metal ion-dependent adhesion site (MIDAS); other site 234267010503 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 234267010504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010505 active site 234267010506 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010507 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010508 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 234267010509 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010510 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010511 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267010512 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267010513 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267010514 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 234267010515 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 234267010516 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 234267010517 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 234267010518 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 234267010519 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 234267010520 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 234267010521 active site 234267010522 Zn binding site [ion binding]; other site 234267010523 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267010524 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267010525 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267010526 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267010527 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010528 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267010529 active site 234267010530 ATP binding site [chemical binding]; other site 234267010531 substrate binding site [chemical binding]; other site 234267010532 activation loop (A-loop); other site 234267010533 TPR repeat; Region: TPR_11; pfam13414 234267010534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010535 TPR motif; other site 234267010536 binding surface 234267010537 TPR repeat; Region: TPR_11; pfam13414 234267010538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010539 binding surface 234267010540 TPR motif; other site 234267010541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267010542 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267010543 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 234267010544 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 234267010545 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267010546 Walker A/P-loop; other site 234267010547 ATP binding site [chemical binding]; other site 234267010548 Q-loop/lid; other site 234267010549 ABC transporter signature motif; other site 234267010550 Walker B; other site 234267010551 D-loop; other site 234267010552 H-loop/switch region; other site 234267010553 Predicted transcriptional regulators [Transcription]; Region: COG1725 234267010554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267010555 DNA-binding site [nucleotide binding]; DNA binding site 234267010556 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 234267010557 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 234267010558 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 234267010559 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267010560 Cupin domain; Region: Cupin_2; pfam07883 234267010561 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267010562 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267010563 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267010564 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267010565 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267010566 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267010567 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267010568 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 234267010569 homotrimer interaction site [polypeptide binding]; other site 234267010570 putative active site [active] 234267010571 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 234267010572 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267010573 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 234267010574 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267010575 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267010576 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267010577 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 234267010578 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267010579 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 234267010580 structural tetrad; other site 234267010581 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 234267010582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267010583 Walker A motif; other site 234267010584 ATP binding site [chemical binding]; other site 234267010585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267010586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267010587 DNA binding site [nucleotide binding] 234267010588 Cupin domain; Region: Cupin_2; cl17218 234267010589 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 234267010590 active site 1 [active] 234267010591 dimer interface [polypeptide binding]; other site 234267010592 hexamer interface [polypeptide binding]; other site 234267010593 active site 2 [active] 234267010594 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267010595 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 234267010596 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267010597 Cytochrome c; Region: Cytochrom_C; pfam00034 234267010598 PAS domain S-box; Region: sensory_box; TIGR00229 234267010599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267010600 putative active site [active] 234267010601 heme pocket [chemical binding]; other site 234267010602 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267010603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267010604 putative active site [active] 234267010605 heme pocket [chemical binding]; other site 234267010606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267010607 dimer interface [polypeptide binding]; other site 234267010608 phosphorylation site [posttranslational modification] 234267010609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267010610 ATP binding site [chemical binding]; other site 234267010611 Mg2+ binding site [ion binding]; other site 234267010612 G-X-G motif; other site 234267010613 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267010614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267010615 active site 234267010616 phosphorylation site [posttranslational modification] 234267010617 intermolecular recognition site; other site 234267010618 dimerization interface [polypeptide binding]; other site 234267010619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267010620 active site 234267010621 phosphorylation site [posttranslational modification] 234267010622 intermolecular recognition site; other site 234267010623 dimerization interface [polypeptide binding]; other site 234267010624 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 234267010625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267010626 S-adenosylmethionine binding site [chemical binding]; other site 234267010627 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010629 FtsX-like permease family; Region: FtsX; pfam02687 234267010630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010631 NADH dehydrogenase subunit B; Validated; Region: PRK06411 234267010632 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 234267010633 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 234267010634 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 234267010635 iron binding site [ion binding]; other site 234267010636 TPR repeat; Region: TPR_11; pfam13414 234267010637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010638 TPR motif; other site 234267010639 binding surface 234267010640 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 234267010641 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234267010642 minor groove reading motif; other site 234267010643 helix-hairpin-helix signature motif; other site 234267010644 substrate binding pocket [chemical binding]; other site 234267010645 active site 234267010646 BON domain; Region: BON; pfam04972 234267010647 BON domain; Region: BON; pfam04972 234267010648 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010649 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010650 FtsX-like permease family; Region: FtsX; pfam02687 234267010651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010652 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267010653 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 234267010654 Predicted flavoprotein [General function prediction only]; Region: COG0431 234267010655 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234267010656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267010657 Response regulator receiver domain; Region: Response_reg; pfam00072 234267010658 phosphorylation site [posttranslational modification] 234267010659 intermolecular recognition site; other site 234267010660 FecR protein; Region: FecR; pfam04773 234267010661 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267010662 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267010663 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 234267010664 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010665 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010666 FtsX-like permease family; Region: FtsX; pfam02687 234267010667 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010668 FtsX-like permease family; Region: FtsX; pfam02687 234267010669 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267010670 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267010671 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 234267010672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010673 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267010674 FtsX-like permease family; Region: FtsX; pfam02687 234267010675 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010676 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267010677 FtsX-like permease family; Region: FtsX; pfam02687 234267010678 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 234267010679 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 234267010680 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 234267010681 rod shape-determining protein MreB; Provisional; Region: PRK13927 234267010682 MreB and similar proteins; Region: MreB_like; cd10225 234267010683 nucleotide binding site [chemical binding]; other site 234267010684 Mg binding site [ion binding]; other site 234267010685 putative protofilament interaction site [polypeptide binding]; other site 234267010686 RodZ interaction site [polypeptide binding]; other site 234267010687 rod shape-determining protein MreC; Provisional; Region: PRK13922 234267010688 rod shape-determining protein MreC; Region: MreC; pfam04085 234267010689 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 234267010690 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267010691 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010692 active site 234267010693 ATP binding site [chemical binding]; other site 234267010694 substrate binding site [chemical binding]; other site 234267010695 activation loop (A-loop); other site 234267010696 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 234267010697 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 234267010698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267010699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267010700 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 234267010701 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 234267010702 active site 234267010703 dimer interface [polypeptide binding]; other site 234267010704 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 234267010705 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 234267010706 active site 234267010707 FMN binding site [chemical binding]; other site 234267010708 substrate binding site [chemical binding]; other site 234267010709 3Fe-4S cluster binding site [ion binding]; other site 234267010710 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 234267010711 domain interface; other site 234267010712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234267010713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267010714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234267010715 dimerization interface [polypeptide binding]; other site 234267010716 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010717 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010718 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267010719 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267010720 Sulfatase; Region: Sulfatase; pfam00884 234267010721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267010722 binding surface 234267010723 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267010724 TPR motif; other site 234267010725 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267010726 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 234267010727 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 234267010728 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 234267010729 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 234267010730 ethanolamine permease; Region: 2A0305; TIGR00908 234267010731 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267010732 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267010733 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 234267010734 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 234267010735 Ligand binding site; other site 234267010736 Putative Catalytic site; other site 234267010737 DXD motif; other site 234267010738 DinB superfamily; Region: DinB_2; pfam12867 234267010739 Inward rectifier potassium channel; Region: IRK; pfam01007 234267010740 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 234267010741 active site 234267010742 YceI-like domain; Region: YceI; smart00867 234267010743 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 234267010744 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 234267010745 active site 234267010746 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010747 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010748 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010749 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267010750 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010751 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010752 FtsX-like permease family; Region: FtsX; pfam02687 234267010753 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010754 FtsX-like permease family; Region: FtsX; pfam02687 234267010755 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267010756 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267010757 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267010758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267010759 DNA binding residues [nucleotide binding] 234267010760 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267010761 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267010762 active site 234267010763 ATP binding site [chemical binding]; other site 234267010764 substrate binding site [chemical binding]; other site 234267010765 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267010766 substrate binding site [chemical binding]; other site 234267010767 activation loop (A-loop); other site 234267010768 activation loop (A-loop); other site 234267010769 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 234267010770 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 234267010771 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 234267010772 Na binding site [ion binding]; other site 234267010773 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 234267010774 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 234267010775 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 234267010776 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 234267010777 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 234267010778 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234267010779 putative active site [active] 234267010780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267010781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267010782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267010783 Walker A/P-loop; other site 234267010784 ATP binding site [chemical binding]; other site 234267010785 Q-loop/lid; other site 234267010786 ABC transporter signature motif; other site 234267010787 Walker B; other site 234267010788 D-loop; other site 234267010789 H-loop/switch region; other site 234267010790 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 234267010791 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 234267010792 catalytic residues [active] 234267010793 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 234267010794 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 234267010795 substrate binding site [chemical binding]; other site 234267010796 glutamase interaction surface [polypeptide binding]; other site 234267010797 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 234267010798 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 234267010799 putative active site [active] 234267010800 oxyanion strand; other site 234267010801 catalytic triad [active] 234267010802 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 234267010803 putative active site pocket [active] 234267010804 4-fold oligomerization interface [polypeptide binding]; other site 234267010805 metal binding residues [ion binding]; metal-binding site 234267010806 3-fold/trimer interface [polypeptide binding]; other site 234267010807 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 234267010808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267010809 motif II; other site 234267010810 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 234267010811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267010812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267010813 homodimer interface [polypeptide binding]; other site 234267010814 catalytic residue [active] 234267010815 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 234267010816 histidinol dehydrogenase; Region: hisD; TIGR00069 234267010817 NAD binding site [chemical binding]; other site 234267010818 dimerization interface [polypeptide binding]; other site 234267010819 product binding site; other site 234267010820 substrate binding site [chemical binding]; other site 234267010821 zinc binding site [ion binding]; other site 234267010822 catalytic residues [active] 234267010823 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 234267010824 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 234267010825 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 234267010826 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 234267010827 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267010828 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267010829 GAF domain; Region: GAF; pfam01590 234267010830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267010831 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267010832 putative active site [active] 234267010833 heme pocket [chemical binding]; other site 234267010834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267010835 dimer interface [polypeptide binding]; other site 234267010836 phosphorylation site [posttranslational modification] 234267010837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267010838 ATP binding site [chemical binding]; other site 234267010839 Mg2+ binding site [ion binding]; other site 234267010840 G-X-G motif; other site 234267010841 Response regulator receiver domain; Region: Response_reg; pfam00072 234267010842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267010843 active site 234267010844 phosphorylation site [posttranslational modification] 234267010845 intermolecular recognition site; other site 234267010846 dimerization interface [polypeptide binding]; other site 234267010847 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 234267010848 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267010849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267010850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267010851 active site 234267010852 catalytic tetrad [active] 234267010853 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 234267010854 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 234267010855 TPP-binding site [chemical binding]; other site 234267010856 dimer interface [polypeptide binding]; other site 234267010857 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234267010858 PYR/PP interface [polypeptide binding]; other site 234267010859 dimer interface [polypeptide binding]; other site 234267010860 TPP binding site [chemical binding]; other site 234267010861 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267010862 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 234267010863 aspartate racemase; Region: asp_race; TIGR00035 234267010864 GYD domain; Region: GYD; pfam08734 234267010865 Cation efflux family; Region: Cation_efflux; cl00316 234267010866 Response regulator receiver domain; Region: Response_reg; pfam00072 234267010867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267010868 active site 234267010869 phosphorylation site [posttranslational modification] 234267010870 intermolecular recognition site; other site 234267010871 dimerization interface [polypeptide binding]; other site 234267010872 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267010873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267010874 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267010875 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 234267010876 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 234267010877 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234267010878 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234267010879 NIPSNAP; Region: NIPSNAP; pfam07978 234267010880 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267010881 Winged helix-turn helix; Region: HTH_29; pfam13551 234267010882 DNA-binding interface [nucleotide binding]; DNA binding site 234267010883 Homeodomain-like domain; Region: HTH_32; pfam13565 234267010884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267010885 Integrase core domain; Region: rve; pfam00665 234267010886 Integrase core domain; Region: rve_3; pfam13683 234267010887 serine O-acetyltransferase; Region: cysE; TIGR01172 234267010888 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 234267010889 trimer interface [polypeptide binding]; other site 234267010890 active site 234267010891 substrate binding site [chemical binding]; other site 234267010892 CoA binding site [chemical binding]; other site 234267010893 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 234267010894 4Fe-4S binding domain; Region: Fer4; pfam00037 234267010895 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267010896 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267010897 catalytic residues [active] 234267010898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267010899 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267010900 NAD(P) binding site [chemical binding]; other site 234267010901 active site 234267010902 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 234267010903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267010904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267010905 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234267010906 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267010907 anti sigma factor interaction site; other site 234267010908 regulatory phosphorylation site [posttranslational modification]; other site 234267010909 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 234267010910 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 234267010911 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267010912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267010913 NAD(P) binding site [chemical binding]; other site 234267010914 active site 234267010915 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 234267010916 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267010917 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267010918 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010919 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267010920 active site 234267010921 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267010922 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267010923 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 234267010924 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 234267010925 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 234267010926 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 234267010927 putative active site [active] 234267010928 metal binding site [ion binding]; metal-binding site 234267010929 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267010930 Rrf2 family protein; Region: rrf2_super; TIGR00738 234267010931 Transcriptional regulator; Region: Rrf2; pfam02082 234267010932 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 234267010933 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 234267010934 oligomer interface [polypeptide binding]; other site 234267010935 active site residues [active] 234267010936 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267010937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267010938 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267010939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267010940 putative substrate translocation pore; other site 234267010941 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234267010942 MarR family; Region: MarR; pfam01047 234267010943 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267010944 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267010945 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 234267010946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267010947 ATP binding site [chemical binding]; other site 234267010948 putative Mg++ binding site [ion binding]; other site 234267010949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267010950 nucleotide binding region [chemical binding]; other site 234267010951 ATP-binding site [chemical binding]; other site 234267010952 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 234267010953 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 234267010954 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010955 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010956 FtsX-like permease family; Region: FtsX; pfam02687 234267010957 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010958 FtsX-like permease family; Region: FtsX; pfam02687 234267010959 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 234267010960 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234267010961 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267010962 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267010963 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 234267010964 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 234267010965 active site 234267010966 trimer interface [polypeptide binding]; other site 234267010967 allosteric site; other site 234267010968 active site lid [active] 234267010969 hexamer (dimer of trimers) interface [polypeptide binding]; other site 234267010970 CAAX protease self-immunity; Region: Abi; pfam02517 234267010971 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234267010972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234267010973 Cytochrome c; Region: Cytochrom_C; pfam00034 234267010974 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010975 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010976 FtsX-like permease family; Region: FtsX; pfam02687 234267010977 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010978 FtsX-like permease family; Region: FtsX; pfam02687 234267010979 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267010980 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267010981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267010982 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267010983 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010984 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267010985 FtsX-like permease family; Region: FtsX; pfam02687 234267010986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267010987 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267010988 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 234267010989 carboxylate-amine ligase; Provisional; Region: PRK13515 234267010990 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 234267010991 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234267010992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 234267010993 Putative esterase; Region: Esterase; pfam00756 234267010994 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 234267010995 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 234267010996 EF hand; Region: EF_hand_3; pfam13202 234267010997 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267010998 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267010999 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267011000 putative active site [active] 234267011001 Zn binding site [ion binding]; other site 234267011002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267011003 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234267011004 substrate binding pocket [chemical binding]; other site 234267011005 membrane-bound complex binding site; other site 234267011006 hinge residues; other site 234267011007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267011008 dimer interface [polypeptide binding]; other site 234267011009 phosphorylation site [posttranslational modification] 234267011010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011011 ATP binding site [chemical binding]; other site 234267011012 Mg2+ binding site [ion binding]; other site 234267011013 G-X-G motif; other site 234267011014 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267011015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011016 active site 234267011017 phosphorylation site [posttranslational modification] 234267011018 intermolecular recognition site; other site 234267011019 dimerization interface [polypeptide binding]; other site 234267011020 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267011021 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267011022 Putative esterase; Region: Esterase; pfam00756 234267011023 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 234267011024 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 234267011025 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 234267011026 intersubunit interface [polypeptide binding]; other site 234267011027 active site 234267011028 zinc binding site [ion binding]; other site 234267011029 Na+ binding site [ion binding]; other site 234267011030 phosphoglucomutase; Validated; Region: PRK07564 234267011031 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 234267011032 active site 234267011033 substrate binding site [chemical binding]; other site 234267011034 metal binding site [ion binding]; metal-binding site 234267011035 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267011036 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267011037 active site 234267011038 ATP binding site [chemical binding]; other site 234267011039 substrate binding site [chemical binding]; other site 234267011040 activation loop (A-loop); other site 234267011041 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267011042 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267011043 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 234267011044 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 234267011045 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 234267011046 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 234267011047 Melibiase; Region: Melibiase; pfam02065 234267011048 alpha-galactosidase; Region: PLN02229 234267011049 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267011050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267011051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267011052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234267011053 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 234267011054 NAD(P) binding site [chemical binding]; other site 234267011055 homotetramer interface [polypeptide binding]; other site 234267011056 homodimer interface [polypeptide binding]; other site 234267011057 active site 234267011058 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 234267011059 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267011060 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 234267011061 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 234267011062 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 234267011063 Family of unknown function (DUF490); Region: DUF490; pfam04357 234267011064 Family of unknown function (DUF490); Region: DUF490; pfam04357 234267011065 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267011066 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267011067 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267011068 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267011069 Surface antigen; Region: Bac_surface_Ag; pfam01103 234267011070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267011071 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267011072 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267011073 Sulfatase; Region: Sulfatase; cl17466 234267011074 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267011075 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267011076 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267011077 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267011078 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267011079 putative aminotransferase; Provisional; Region: PRK09105 234267011080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267011081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267011082 homodimer interface [polypeptide binding]; other site 234267011083 catalytic residue [active] 234267011084 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267011085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267011086 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267011087 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267011088 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267011089 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 234267011090 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 234267011091 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 234267011092 putative ligand binding site [chemical binding]; other site 234267011093 putative NAD binding site [chemical binding]; other site 234267011094 putative catalytic site [active] 234267011095 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 234267011096 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 234267011097 classical (c) SDRs; Region: SDR_c; cd05233 234267011098 NAD(P) binding site [chemical binding]; other site 234267011099 active site 234267011100 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011101 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267011102 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267011103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267011104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267011105 active site 234267011106 ATP binding site [chemical binding]; other site 234267011107 substrate binding site [chemical binding]; other site 234267011108 activation loop (A-loop); other site 234267011109 TPR repeat; Region: TPR_11; pfam13414 234267011110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011111 binding surface 234267011112 TPR motif; other site 234267011113 TPR repeat; Region: TPR_11; pfam13414 234267011114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011115 TPR motif; other site 234267011116 binding surface 234267011117 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 234267011118 active site 234267011119 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 234267011120 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 234267011121 active site 234267011122 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 234267011123 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234267011124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267011125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267011126 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 234267011127 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 234267011128 Ligand Binding Site [chemical binding]; other site 234267011129 DNA gyrase subunit A; Validated; Region: PRK05560 234267011130 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 234267011131 CAP-like domain; other site 234267011132 active site 234267011133 primary dimer interface [polypeptide binding]; other site 234267011134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234267011135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234267011136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234267011137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234267011138 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234267011139 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234267011140 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 234267011141 peptidase domain interface [polypeptide binding]; other site 234267011142 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 234267011143 active site 234267011144 catalytic triad [active] 234267011145 calcium binding site [ion binding]; other site 234267011146 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267011147 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267011149 D-galactonate transporter; Region: 2A0114; TIGR00893 234267011150 putative substrate translocation pore; other site 234267011151 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234267011152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267011153 DNA-binding site [nucleotide binding]; DNA binding site 234267011154 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234267011155 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 234267011156 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 234267011157 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 234267011158 active site 234267011159 tetramer interface [polypeptide binding]; other site 234267011160 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 234267011161 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267011162 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267011163 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267011164 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234267011165 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267011166 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267011167 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 234267011168 FOG: PKD repeat [General function prediction only]; Region: COG3291 234267011169 Uncharacterized conserved protein [Function unknown]; Region: COG2006 234267011170 Domain of unknown function (DUF362); Region: DUF362; pfam04015 234267011171 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 234267011172 active site 234267011173 catalytic triad [active] 234267011174 oxyanion hole [active] 234267011175 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011176 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011177 FtsX-like permease family; Region: FtsX; pfam02687 234267011178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011179 FtsX-like permease family; Region: FtsX; pfam02687 234267011180 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267011181 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267011182 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267011183 SdiA-regulated; Region: SdiA-regulated; cd09971 234267011184 PEP-CTERM motif; Region: VPEP; pfam07589 234267011185 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234267011186 Predicted flavoprotein [General function prediction only]; Region: COG0431 234267011187 Pirin-related protein [General function prediction only]; Region: COG1741 234267011188 Pirin; Region: Pirin; pfam02678 234267011189 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 234267011190 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 234267011191 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 234267011192 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 234267011193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267011194 AlkA N-terminal domain; Region: AlkA_N; pfam06029 234267011195 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 234267011196 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234267011197 minor groove reading motif; other site 234267011198 helix-hairpin-helix signature motif; other site 234267011199 substrate binding pocket [chemical binding]; other site 234267011200 active site 234267011201 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 234267011202 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 234267011203 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234267011204 DNA binding site [nucleotide binding] 234267011205 active site 234267011206 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011207 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267011208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267011209 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 234267011210 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267011211 Sulfatase; Region: Sulfatase; pfam00884 234267011212 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 234267011213 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 234267011214 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 234267011215 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 234267011216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267011217 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 234267011218 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234267011219 DNA binding site [nucleotide binding] 234267011220 active site 234267011221 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267011222 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 234267011223 Predicted membrane protein [Function unknown]; Region: COG3503 234267011224 Acyltransferase family; Region: Acyl_transf_3; pfam01757 234267011225 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267011226 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267011227 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267011228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267011229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 234267011230 phosphorylation site [posttranslational modification] 234267011231 intermolecular recognition site; other site 234267011232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267011233 DNA binding site [nucleotide binding] 234267011234 Alginate lyase; Region: Alginate_lyase; pfam05426 234267011235 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011236 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267011237 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267011238 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267011239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267011240 putative DNA binding site [nucleotide binding]; other site 234267011241 putative Zn2+ binding site [ion binding]; other site 234267011242 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 234267011243 putative hydrophobic ligand binding site [chemical binding]; other site 234267011244 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234267011245 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234267011246 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267011247 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267011248 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011249 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011251 FtsX-like permease family; Region: FtsX; pfam02687 234267011252 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234267011253 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011254 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267011255 active site 234267011256 metal binding site [ion binding]; metal-binding site 234267011257 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267011258 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267011259 active site 234267011260 metal binding site [ion binding]; metal-binding site 234267011261 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267011262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267011263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267011264 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 234267011265 Walker A/P-loop; other site 234267011266 ATP binding site [chemical binding]; other site 234267011267 Q-loop/lid; other site 234267011268 ABC transporter signature motif; other site 234267011269 Walker B; other site 234267011270 D-loop; other site 234267011271 H-loop/switch region; other site 234267011272 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267011273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267011274 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267011275 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267011276 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011277 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267011278 glutathione reductase; Region: PLN02546 234267011279 CotH protein; Region: CotH; pfam08757 234267011280 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267011281 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 234267011282 PLD-like domain; Region: PLDc_2; pfam13091 234267011283 putative active site [active] 234267011284 putative catalytic site [active] 234267011285 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 234267011286 PLD-like domain; Region: PLDc_2; pfam13091 234267011287 putative active site [active] 234267011288 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 234267011289 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 234267011290 TMP-binding site; other site 234267011291 ATP-binding site [chemical binding]; other site 234267011292 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234267011293 active site 234267011294 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011295 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267011296 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 234267011297 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 234267011298 EthD domain; Region: EthD; cl17553 234267011299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267011300 D-galactonate transporter; Region: 2A0114; TIGR00893 234267011301 putative substrate translocation pore; other site 234267011302 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011303 TPR repeat; Region: TPR_11; pfam13414 234267011304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011305 binding surface 234267011306 TPR motif; other site 234267011307 TPR repeat; Region: TPR_11; pfam13414 234267011308 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267011309 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 234267011310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 234267011311 ATP binding site [chemical binding]; other site 234267011312 putative Mg++ binding site [ion binding]; other site 234267011313 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 234267011314 Helicase associated domain (HA2); Region: HA2; pfam04408 234267011315 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 234267011316 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234267011317 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267011318 inhibitor site; inhibition site 234267011319 active site 234267011320 dimer interface [polypeptide binding]; other site 234267011321 catalytic residue [active] 234267011322 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267011323 allantoate amidohydrolase; Reviewed; Region: PRK09290 234267011324 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 234267011325 active site 234267011326 metal binding site [ion binding]; metal-binding site 234267011327 dimer interface [polypeptide binding]; other site 234267011328 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 234267011329 active site 234267011330 catalytic triad [active] 234267011331 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267011332 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267011333 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267011334 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267011335 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267011336 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 234267011337 intersubunit interface [polypeptide binding]; other site 234267011338 active site 234267011339 Zn2+ binding site [ion binding]; other site 234267011340 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 234267011341 active site 234267011342 intersubunit interface [polypeptide binding]; other site 234267011343 Zn2+ binding site [ion binding]; other site 234267011344 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 234267011345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 234267011346 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267011347 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267011348 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267011349 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267011350 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 234267011351 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234267011352 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267011353 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 234267011354 MarC family integral membrane protein; Region: MarC; cl00919 234267011355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267011356 RNA binding surface [nucleotide binding]; other site 234267011357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234267011358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267011359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234267011360 dimerization interface [polypeptide binding]; other site 234267011361 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 234267011362 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 234267011363 active site 234267011364 catalytic residues [active] 234267011365 metal binding site [ion binding]; metal-binding site 234267011366 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 234267011367 tartrate dehydrogenase; Region: TTC; TIGR02089 234267011368 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 234267011369 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 234267011370 substrate binding site [chemical binding]; other site 234267011371 ligand binding site [chemical binding]; other site 234267011372 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 234267011373 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 234267011374 hypothetical protein; Provisional; Region: PRK14812 234267011375 substrate binding site [chemical binding]; other site 234267011376 DDE superfamily endonuclease; Region: DDE_3; pfam13358 234267011377 Family of unknown function (DUF706); Region: DUF706; pfam05153 234267011378 MG2 domain; Region: A2M_N; pfam01835 234267011379 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 234267011380 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011381 Alpha-2-macroglobulin family; Region: A2M; pfam00207 234267011382 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 234267011383 surface patch; other site 234267011384 thioester region; other site 234267011385 A-macroglobulin complement component; Region: A2M_comp; pfam07678 234267011386 specificity defining residues; other site 234267011387 A-macroglobulin receptor; Region: A2M_recep; pfam07677 234267011388 Uncharacterized conserved protein [Function unknown]; Region: COG5316 234267011389 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 234267011390 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 234267011391 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267011392 Trp docking motif [polypeptide binding]; other site 234267011393 PQQ-like domain; Region: PQQ_2; pfam13360 234267011394 putative active site [active] 234267011395 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267011396 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267011397 DNA interaction; other site 234267011398 Metal-binding active site; metal-binding site 234267011399 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011400 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267011401 HEAT repeats; Region: HEAT_2; pfam13646 234267011402 HEAT repeat; Region: HEAT; pfam02985 234267011403 TPR repeat; Region: TPR_11; pfam13414 234267011404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011405 binding surface 234267011406 TPR motif; other site 234267011407 TPR repeat; Region: TPR_11; pfam13414 234267011408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011409 binding surface 234267011410 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267011411 TPR motif; other site 234267011412 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 234267011413 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 234267011414 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 234267011415 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267011416 Sulfatase; Region: Sulfatase; cl17466 234267011417 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 234267011418 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011419 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011420 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 234267011421 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 234267011422 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 234267011423 transmembrane helices; other site 234267011424 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 234267011425 active site 234267011426 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267011427 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267011428 ligand binding site [chemical binding]; other site 234267011429 imidazolonepropionase; Validated; Region: PRK09356 234267011430 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267011431 active site 234267011432 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 234267011433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267011434 RNA binding surface [nucleotide binding]; other site 234267011435 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 234267011436 active site 234267011437 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267011438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267011439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267011440 DNA binding residues [nucleotide binding] 234267011441 Putative zinc-finger; Region: zf-HC2; pfam13490 234267011442 HEAT repeats; Region: HEAT_2; pfam13646 234267011443 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267011444 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267011445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267011446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267011447 DNA binding residues [nucleotide binding] 234267011448 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 234267011449 cofactor binding site; other site 234267011450 metal binding site [ion binding]; metal-binding site 234267011451 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267011452 ATP binding site [chemical binding]; other site 234267011453 Sporulation related domain; Region: SPOR; cl10051 234267011454 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 234267011455 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011456 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267011457 FtsX-like permease family; Region: FtsX; pfam02687 234267011458 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267011459 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267011460 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 234267011461 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267011462 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267011463 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267011464 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 234267011465 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 234267011466 active site 234267011467 dimer interface [polypeptide binding]; other site 234267011468 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 234267011469 Ligand Binding Site [chemical binding]; other site 234267011470 Molecular Tunnel; other site 234267011471 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267011472 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267011473 Phage terminase large subunit; Region: Terminase_3; cl12054 234267011474 Terminase-like family; Region: Terminase_6; pfam03237 234267011475 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 234267011476 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 234267011477 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 234267011478 Putative phage tail protein; Region: Phage-tail_3; pfam13550 234267011479 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 234267011480 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 234267011481 O-Antigen ligase; Region: Wzy_C; pfam04932 234267011482 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267011483 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267011484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011485 FtsX-like permease family; Region: FtsX; pfam02687 234267011486 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011487 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267011488 FtsX-like permease family; Region: FtsX; pfam02687 234267011489 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 234267011490 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267011491 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267011492 catalytic residues [active] 234267011493 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 234267011494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234267011495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267011496 Coenzyme A binding pocket [chemical binding]; other site 234267011497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267011498 FeS/SAM binding site; other site 234267011499 CARDB; Region: CARDB; pfam07705 234267011500 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267011501 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267011502 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267011503 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267011504 active site 234267011505 catalytic tetrad [active] 234267011506 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234267011507 DinB superfamily; Region: DinB_2; pfam12867 234267011508 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234267011509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267011510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267011511 Walker A/P-loop; other site 234267011512 ATP binding site [chemical binding]; other site 234267011513 Q-loop/lid; other site 234267011514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267011515 ABC transporter signature motif; other site 234267011516 Walker B; other site 234267011517 D-loop; other site 234267011518 ABC transporter; Region: ABC_tran_2; pfam12848 234267011519 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267011520 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011522 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011523 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 234267011524 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267011525 Protein export membrane protein; Region: SecD_SecF; cl14618 234267011526 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267011527 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267011528 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 234267011529 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267011530 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 234267011531 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011533 FtsX-like permease family; Region: FtsX; pfam02687 234267011534 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011535 FtsX-like permease family; Region: FtsX; pfam02687 234267011536 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267011537 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 234267011538 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 234267011539 tetramer interface [polypeptide binding]; other site 234267011540 active site 234267011541 Mg2+/Mn2+ binding site [ion binding]; other site 234267011542 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 234267011543 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267011544 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 234267011545 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267011546 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 234267011547 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 234267011548 ATP binding site [chemical binding]; other site 234267011549 Walker A motif; other site 234267011550 hexamer interface [polypeptide binding]; other site 234267011551 Walker B motif; other site 234267011552 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 234267011553 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 234267011554 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 234267011555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267011556 putative NAD(P) binding site [chemical binding]; other site 234267011557 putative active site [active] 234267011558 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 234267011559 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267011560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267011561 homodimer interface [polypeptide binding]; other site 234267011562 catalytic residue [active] 234267011563 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 234267011564 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 234267011565 dimer interface [polypeptide binding]; other site 234267011566 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 234267011567 active site 234267011568 Fe binding site [ion binding]; other site 234267011569 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267011570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011571 active site 234267011572 phosphorylation site [posttranslational modification] 234267011573 intermolecular recognition site; other site 234267011574 dimerization interface [polypeptide binding]; other site 234267011575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267011576 Walker A motif; other site 234267011577 ATP binding site [chemical binding]; other site 234267011578 Walker B motif; other site 234267011579 arginine finger; other site 234267011580 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267011581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267011582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011583 ATP binding site [chemical binding]; other site 234267011584 Mg2+ binding site [ion binding]; other site 234267011585 G-X-G motif; other site 234267011586 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267011587 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 234267011588 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011589 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 234267011590 putative active site [active] 234267011591 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011593 binding surface 234267011594 TPR motif; other site 234267011595 SEC-C motif; Region: SEC-C; pfam02810 234267011596 Protein of unknown function, DUF481; Region: DUF481; pfam04338 234267011597 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267011598 RNA binding site [nucleotide binding]; other site 234267011599 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267011600 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 234267011601 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 234267011602 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 234267011603 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 234267011604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267011605 Helix-turn-helix domain; Region: HTH_37; pfam13744 234267011606 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 234267011607 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 234267011608 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 234267011609 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 234267011610 substrate binding pocket [chemical binding]; other site 234267011611 dimer interface [polypeptide binding]; other site 234267011612 inhibitor binding site; inhibition site 234267011613 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 234267011614 B12 binding site [chemical binding]; other site 234267011615 cobalt ligand [ion binding]; other site 234267011616 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 234267011617 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 234267011618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267011619 S-adenosylmethionine binding site [chemical binding]; other site 234267011620 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011621 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267011622 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267011623 CAAX protease self-immunity; Region: Abi; pfam02517 234267011624 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267011625 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267011626 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267011627 metal ion-dependent adhesion site (MIDAS); other site 234267011628 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234267011629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267011630 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234267011631 Helix-turn-helix domain; Region: HTH_18; pfam12833 234267011632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267011633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011634 binding surface 234267011635 TPR repeat; Region: TPR_11; pfam13414 234267011636 TPR motif; other site 234267011637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011638 binding surface 234267011639 TPR motif; other site 234267011640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011641 binding surface 234267011642 TPR motif; other site 234267011643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011644 TPR motif; other site 234267011645 binding surface 234267011646 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 234267011647 lytic murein transglycosylase; Region: MltB_2; TIGR02283 234267011648 Putative zinc-finger; Region: zf-HC2; pfam13490 234267011649 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267011650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267011651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267011652 DNA binding residues [nucleotide binding] 234267011653 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 234267011654 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 234267011655 lipoyl attachment site [posttranslational modification]; other site 234267011656 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 234267011657 4Fe-4S binding domain; Region: Fer4; cl02805 234267011658 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 234267011659 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 234267011660 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 234267011661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267011662 dimerization interface [polypeptide binding]; other site 234267011663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267011664 dimer interface [polypeptide binding]; other site 234267011665 phosphorylation site [posttranslational modification] 234267011666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011667 ATP binding site [chemical binding]; other site 234267011668 Mg2+ binding site [ion binding]; other site 234267011669 G-X-G motif; other site 234267011670 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267011671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011672 active site 234267011673 phosphorylation site [posttranslational modification] 234267011674 intermolecular recognition site; other site 234267011675 dimerization interface [polypeptide binding]; other site 234267011676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267011677 Walker A motif; other site 234267011678 ATP binding site [chemical binding]; other site 234267011679 Walker B motif; other site 234267011680 arginine finger; other site 234267011681 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267011682 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 234267011683 active site 234267011684 Zn binding site [ion binding]; other site 234267011685 Acylphosphatase; Region: Acylphosphatase; pfam00708 234267011686 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 234267011687 HypF finger; Region: zf-HYPF; pfam07503 234267011688 HypF finger; Region: zf-HYPF; pfam07503 234267011689 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 234267011690 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 234267011691 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 234267011692 Tannase and feruloyl esterase; Region: Tannase; pfam07519 234267011693 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267011694 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 234267011695 AAA domain; Region: AAA_31; pfam13614 234267011696 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267011697 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 234267011698 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 234267011699 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 234267011700 GTP binding site [chemical binding]; other site 234267011701 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 234267011702 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 234267011703 catalytic motif [active] 234267011704 Zn binding site [ion binding]; other site 234267011705 RibD C-terminal domain; Region: RibD_C; cl17279 234267011706 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 234267011707 Lumazine binding domain; Region: Lum_binding; pfam00677 234267011708 Lumazine binding domain; Region: Lum_binding; pfam00677 234267011709 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011710 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267011711 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267011712 metal ion-dependent adhesion site (MIDAS); other site 234267011713 Predicted membrane protein [Function unknown]; Region: COG3918 234267011714 mercuric reductase; Validated; Region: PRK06370 234267011715 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234267011716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267011717 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234267011718 CcmE; Region: CcmE; cl00994 234267011719 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 234267011720 Cytochrome C biogenesis protein; Region: CcmH; cl01179 234267011721 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 234267011722 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 234267011723 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267011724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267011725 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267011726 Walker A/P-loop; other site 234267011727 ATP binding site [chemical binding]; other site 234267011728 Q-loop/lid; other site 234267011729 ABC transporter signature motif; other site 234267011730 Walker B; other site 234267011731 D-loop; other site 234267011732 H-loop/switch region; other site 234267011733 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 234267011734 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 234267011735 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267011736 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267011737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267011738 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267011739 active site 234267011740 ATP binding site [chemical binding]; other site 234267011741 substrate binding site [chemical binding]; other site 234267011742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267011743 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234267011744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011745 binding surface 234267011746 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267011747 TPR motif; other site 234267011748 TPR repeat; Region: TPR_11; pfam13414 234267011749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267011750 TPR motif; other site 234267011751 binding surface 234267011752 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267011753 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 234267011754 Zn binding site [ion binding]; other site 234267011755 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 234267011756 proposed catalytic triad [active] 234267011757 active site nucleophile [active] 234267011758 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 234267011759 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 234267011760 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 234267011761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234267011762 inhibitor-cofactor binding pocket; inhibition site 234267011763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267011764 catalytic residue [active] 234267011765 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 234267011766 active site 234267011767 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267011768 Sulfatase; Region: Sulfatase; cl17466 234267011769 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 234267011770 short chain dehydrogenase; Provisional; Region: PRK08339 234267011771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267011772 NAD(P) binding site [chemical binding]; other site 234267011773 active site 234267011774 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267011775 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267011776 Walker A/P-loop; other site 234267011777 ATP binding site [chemical binding]; other site 234267011778 Q-loop/lid; other site 234267011779 ABC transporter signature motif; other site 234267011780 Walker B; other site 234267011781 D-loop; other site 234267011782 H-loop/switch region; other site 234267011783 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011784 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011785 FtsX-like permease family; Region: FtsX; pfam02687 234267011786 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011787 FtsX-like permease family; Region: FtsX; pfam02687 234267011788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267011789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267011790 dimer interface [polypeptide binding]; other site 234267011791 phosphorylation site [posttranslational modification] 234267011792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011793 ATP binding site [chemical binding]; other site 234267011794 Mg2+ binding site [ion binding]; other site 234267011795 G-X-G motif; other site 234267011796 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267011797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267011798 putative active site [active] 234267011799 heme pocket [chemical binding]; other site 234267011800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267011801 dimer interface [polypeptide binding]; other site 234267011802 phosphorylation site [posttranslational modification] 234267011803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011804 ATP binding site [chemical binding]; other site 234267011805 Mg2+ binding site [ion binding]; other site 234267011806 G-X-G motif; other site 234267011807 Response regulator receiver domain; Region: Response_reg; pfam00072 234267011808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011809 active site 234267011810 phosphorylation site [posttranslational modification] 234267011811 intermolecular recognition site; other site 234267011812 dimerization interface [polypeptide binding]; other site 234267011813 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 234267011814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267011815 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267011816 Walker A motif; other site 234267011817 ATP binding site [chemical binding]; other site 234267011818 Walker B motif; other site 234267011819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234267011820 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267011821 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267011822 metal ion-dependent adhesion site (MIDAS); other site 234267011823 short chain dehydrogenase; Provisional; Region: PRK06500 234267011824 classical (c) SDRs; Region: SDR_c; cd05233 234267011825 NAD(P) binding site [chemical binding]; other site 234267011826 active site 234267011827 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234267011828 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234267011829 putative NAD(P) binding site [chemical binding]; other site 234267011830 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267011831 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011832 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011833 FtsX-like permease family; Region: FtsX; pfam02687 234267011834 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011835 FtsX-like permease family; Region: FtsX; pfam02687 234267011836 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011837 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011838 FtsX-like permease family; Region: FtsX; pfam02687 234267011839 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011840 FtsX-like permease family; Region: FtsX; pfam02687 234267011841 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267011842 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267011843 Asp-box motif; other site 234267011844 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267011845 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011846 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267011847 FtsX-like permease family; Region: FtsX; pfam02687 234267011848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267011849 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234267011850 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267011851 active site 234267011852 ATP binding site [chemical binding]; other site 234267011853 substrate binding site [chemical binding]; other site 234267011854 activation loop (A-loop); other site 234267011855 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267011856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267011857 S-adenosylmethionine binding site [chemical binding]; other site 234267011858 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267011859 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 234267011860 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267011861 metal binding site [ion binding]; metal-binding site 234267011862 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267011863 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 234267011864 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 234267011865 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234267011866 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234267011867 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 234267011868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234267011869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267011870 Coenzyme A binding pocket [chemical binding]; other site 234267011871 Protein of unknown function DUF86; Region: DUF86; cl01031 234267011872 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 234267011873 active site 234267011874 NTP binding site [chemical binding]; other site 234267011875 metal binding triad [ion binding]; metal-binding site 234267011876 antibiotic binding site [chemical binding]; other site 234267011877 SIR2-like domain; Region: SIR2_2; pfam13289 234267011878 Protein of unknown function (DUF796); Region: DUF796; pfam05638 234267011879 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267011880 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267011881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267011882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267011883 dimerization interface [polypeptide binding]; other site 234267011884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267011885 dimer interface [polypeptide binding]; other site 234267011886 phosphorylation site [posttranslational modification] 234267011887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011888 ATP binding site [chemical binding]; other site 234267011889 Mg2+ binding site [ion binding]; other site 234267011890 G-X-G motif; other site 234267011891 Response regulator receiver domain; Region: Response_reg; pfam00072 234267011892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011893 active site 234267011894 phosphorylation site [posttranslational modification] 234267011895 intermolecular recognition site; other site 234267011896 dimerization interface [polypeptide binding]; other site 234267011897 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267011898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011899 active site 234267011900 phosphorylation site [posttranslational modification] 234267011901 intermolecular recognition site; other site 234267011902 dimerization interface [polypeptide binding]; other site 234267011903 PBP superfamily domain; Region: PBP_like_2; cl17296 234267011904 fumarate hydratase; Reviewed; Region: fumC; PRK00485 234267011905 Class II fumarases; Region: Fumarase_classII; cd01362 234267011906 active site 234267011907 tetramer interface [polypeptide binding]; other site 234267011908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011909 active site 234267011910 phosphorylation site [posttranslational modification] 234267011911 intermolecular recognition site; other site 234267011912 dimerization interface [polypeptide binding]; other site 234267011913 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267011914 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267011915 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267011916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011917 active site 234267011918 phosphorylation site [posttranslational modification] 234267011919 intermolecular recognition site; other site 234267011920 dimerization interface [polypeptide binding]; other site 234267011921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 234267011922 dimer interface [polypeptide binding]; other site 234267011923 phosphorylation site [posttranslational modification] 234267011924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011925 Response regulator receiver domain; Region: Response_reg; pfam00072 234267011926 active site 234267011927 phosphorylation site [posttranslational modification] 234267011928 intermolecular recognition site; other site 234267011929 dimerization interface [polypeptide binding]; other site 234267011930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267011931 dimer interface [polypeptide binding]; other site 234267011932 phosphorylation site [posttranslational modification] 234267011933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011934 ATP binding site [chemical binding]; other site 234267011935 Mg2+ binding site [ion binding]; other site 234267011936 G-X-G motif; other site 234267011937 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 234267011938 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 234267011939 RNA binding site [nucleotide binding]; other site 234267011940 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 234267011941 RNA binding site [nucleotide binding]; other site 234267011942 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 234267011943 RNA binding site [nucleotide binding]; other site 234267011944 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267011945 RNA binding site [nucleotide binding]; other site 234267011946 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 234267011947 RNA binding site [nucleotide binding]; other site 234267011948 S1 RNA binding domain; Region: S1; pfam00575 234267011949 RNA binding site [nucleotide binding]; other site 234267011950 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 234267011951 IHF - DNA interface [nucleotide binding]; other site 234267011952 IHF dimer interface [polypeptide binding]; other site 234267011953 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 234267011954 nucleotide binding site/active site [active] 234267011955 HIT family signature motif; other site 234267011956 catalytic residue [active] 234267011957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234267011958 Histidine kinase; Region: His_kinase; pfam06580 234267011959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267011960 ATP binding site [chemical binding]; other site 234267011961 Mg2+ binding site [ion binding]; other site 234267011962 G-X-G motif; other site 234267011963 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267011964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267011965 active site 234267011966 phosphorylation site [posttranslational modification] 234267011967 intermolecular recognition site; other site 234267011968 dimerization interface [polypeptide binding]; other site 234267011969 LytTr DNA-binding domain; Region: LytTR; smart00850 234267011970 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267011971 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267011972 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267011973 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267011974 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267011975 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267011976 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267011977 TPR repeat; Region: TPR_11; pfam13414 234267011978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267011979 binding surface 234267011980 TPR motif; other site 234267011981 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267011982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267011983 ligand binding site [chemical binding]; other site 234267011984 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267011985 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267011986 ligand binding site [chemical binding]; other site 234267011987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267011988 ligand binding site [chemical binding]; other site 234267011989 flexible hinge region; other site 234267011990 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 234267011991 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267011992 4Fe-4S binding domain; Region: Fer4; pfam00037 234267011993 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267011994 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234267011995 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267011996 phosphopeptide binding site; other site 234267011997 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267011998 Protein phosphatase 2C; Region: PP2C; pfam00481 234267011999 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 234267012000 active site 234267012001 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267012002 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267012003 active site 234267012004 ATP binding site [chemical binding]; other site 234267012005 substrate binding site [chemical binding]; other site 234267012006 activation loop (A-loop); other site 234267012007 Zinc finger domain; Region: ZnF_RBZ; smart00547 234267012008 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267012009 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267012010 Uncharacterized conserved protein [Function unknown]; Region: COG5276 234267012011 LVIVD repeat; Region: LVIVD; pfam08309 234267012012 Domain of unknown function (DUF336); Region: DUF336; cl01249 234267012013 Domain of unknown function (DUF336); Region: DUF336; cl01249 234267012014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267012015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267012016 active site 234267012017 phosphorylation site [posttranslational modification] 234267012018 intermolecular recognition site; other site 234267012019 dimerization interface [polypeptide binding]; other site 234267012020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267012021 DNA binding site [nucleotide binding] 234267012022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267012023 dimer interface [polypeptide binding]; other site 234267012024 phosphorylation site [posttranslational modification] 234267012025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267012026 ATP binding site [chemical binding]; other site 234267012027 Mg2+ binding site [ion binding]; other site 234267012028 G-X-G motif; other site 234267012029 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267012030 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267012031 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012032 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267012033 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267012034 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 234267012035 LysE type translocator; Region: LysE; cl00565 234267012036 Cytochrome c; Region: Cytochrom_C; pfam00034 234267012037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267012038 non-specific DNA binding site [nucleotide binding]; other site 234267012039 salt bridge; other site 234267012040 sequence-specific DNA binding site [nucleotide binding]; other site 234267012041 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 234267012042 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234267012043 Protein of unknown function (DUF3738); Region: DUF3738; pfam12543 234267012044 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 234267012045 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 234267012046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267012047 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 234267012048 active site 234267012049 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 234267012050 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 234267012051 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 234267012052 PspC domain; Region: PspC; pfam04024 234267012053 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 234267012054 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 234267012055 transmembrane helices; other site 234267012056 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 234267012057 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234267012058 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267012059 Probable Catalytic site; other site 234267012060 metal-binding site 234267012061 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267012062 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 234267012063 Predicted integral membrane protein [Function unknown]; Region: COG3548 234267012064 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267012068 GAF domain; Region: GAF; pfam01590 234267012069 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267012070 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267012071 amidase; Provisional; Region: PRK08137 234267012072 Amidase; Region: Amidase; cl11426 234267012073 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267012074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267012075 DNA-binding site [nucleotide binding]; DNA binding site 234267012076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267012077 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267012078 ligand binding site [chemical binding]; other site 234267012079 dimerization interface [polypeptide binding]; other site 234267012080 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234267012081 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267012082 Ligand binding site; other site 234267012083 Putative Catalytic site; other site 234267012084 DXD motif; other site 234267012085 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267012086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267012087 S-adenosylmethionine binding site [chemical binding]; other site 234267012088 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 234267012089 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 234267012090 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267012091 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267012092 Ligand binding site; other site 234267012093 Putative Catalytic site; other site 234267012094 DXD motif; other site 234267012095 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267012096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267012097 S-adenosylmethionine binding site [chemical binding]; other site 234267012098 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 234267012099 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 234267012100 Ligand binding site; other site 234267012101 Putative Catalytic site; other site 234267012102 DXD motif; other site 234267012103 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267012104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267012105 S-adenosylmethionine binding site [chemical binding]; other site 234267012106 ADP-glucose phosphorylase; Region: PLN02643 234267012107 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 234267012108 dimer interface [polypeptide binding]; other site 234267012109 active site 234267012110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012111 binding surface 234267012112 TPR motif; other site 234267012113 TPR repeat; Region: TPR_11; pfam13414 234267012114 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 234267012115 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 234267012116 phosphate binding site [ion binding]; other site 234267012117 putative substrate binding pocket [chemical binding]; other site 234267012118 dimer interface [polypeptide binding]; other site 234267012119 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 234267012120 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 234267012121 Substrate binding site; other site 234267012122 Mg++ binding site; other site 234267012123 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 234267012124 active site 234267012125 substrate binding site [chemical binding]; other site 234267012126 CoA binding site [chemical binding]; other site 234267012127 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267012128 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267012129 metal ion-dependent adhesion site (MIDAS); other site 234267012130 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 234267012131 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 234267012132 Probable zinc-binding domain; Region: zf-trcl; pfam13451 234267012133 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 234267012134 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 234267012135 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 234267012136 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 234267012137 ligand binding site; other site 234267012138 oligomer interface; other site 234267012139 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 234267012140 dimer interface [polypeptide binding]; other site 234267012141 N-terminal domain interface [polypeptide binding]; other site 234267012142 sulfate 1 binding site; other site 234267012143 enolase; Provisional; Region: eno; PRK00077 234267012144 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 234267012145 dimer interface [polypeptide binding]; other site 234267012146 metal binding site [ion binding]; metal-binding site 234267012147 substrate binding pocket [chemical binding]; other site 234267012148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234267012149 catalytic core [active] 234267012150 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234267012151 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267012152 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 234267012153 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 234267012154 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 234267012155 Protein of unknown function (DUF420); Region: DUF420; pfam04238 234267012156 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 234267012157 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 234267012158 Cu(I) binding site [ion binding]; other site 234267012159 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234267012160 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234267012161 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267012162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267012163 Walker A/P-loop; other site 234267012164 ATP binding site [chemical binding]; other site 234267012165 Q-loop/lid; other site 234267012166 ABC transporter signature motif; other site 234267012167 Walker B; other site 234267012168 D-loop; other site 234267012169 H-loop/switch region; other site 234267012170 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 234267012171 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 234267012172 UbiA prenyltransferase family; Region: UbiA; pfam01040 234267012173 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 234267012174 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012175 Cytochrome c; Region: Cytochrom_C; cl11414 234267012176 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 234267012177 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 234267012178 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 234267012179 heme bH binding site [chemical binding]; other site 234267012180 intrachain domain interface; other site 234267012181 Qi binding site; other site 234267012182 heme bL binding site [chemical binding]; other site 234267012183 interchain domain interface [polypeptide binding]; other site 234267012184 Qo binding site; other site 234267012185 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234267012186 iron-sulfur cluster [ion binding]; other site 234267012187 [2Fe-2S] cluster binding site [ion binding]; other site 234267012188 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 234267012189 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 234267012190 active site 234267012191 dimer interface [polypeptide binding]; other site 234267012192 Predicted membrane protein [Function unknown]; Region: COG1289 234267012193 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 234267012194 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267012195 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267012196 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267012197 active site 234267012198 ATP binding site [chemical binding]; other site 234267012199 substrate binding site [chemical binding]; other site 234267012200 activation loop (A-loop); other site 234267012201 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 234267012202 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 234267012203 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 234267012204 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 234267012205 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 234267012206 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267012207 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234267012208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267012209 Coenzyme A binding pocket [chemical binding]; other site 234267012210 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267012211 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267012212 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267012213 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267012214 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 234267012215 M28 Zn-Peptidases; Region: M28_like_7; cd05643 234267012216 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267012217 putative metal binding site [ion binding]; other site 234267012218 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 234267012219 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 234267012220 heterodimer interface [polypeptide binding]; other site 234267012221 active site 234267012222 FMN binding site [chemical binding]; other site 234267012223 homodimer interface [polypeptide binding]; other site 234267012224 substrate binding site [chemical binding]; other site 234267012225 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234267012226 Helix-turn-helix domain; Region: HTH_25; pfam13413 234267012227 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 234267012228 active site 2 [active] 234267012229 active site 1 [active] 234267012230 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267012231 Low molecular weight phosphatase family; Region: LMWPc; cd00115 234267012232 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 234267012233 active site 234267012234 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 234267012235 Sodium Bile acid symporter family; Region: SBF; cl17470 234267012236 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267012237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267012238 S-adenosylmethionine binding site [chemical binding]; other site 234267012239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267012240 dimerization interface [polypeptide binding]; other site 234267012241 putative DNA binding site [nucleotide binding]; other site 234267012242 putative Zn2+ binding site [ion binding]; other site 234267012243 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 234267012244 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 234267012245 Walker A/P-loop; other site 234267012246 ATP binding site [chemical binding]; other site 234267012247 Q-loop/lid; other site 234267012248 ABC transporter signature motif; other site 234267012249 Walker B; other site 234267012250 D-loop; other site 234267012251 H-loop/switch region; other site 234267012252 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 234267012253 putative carbohydrate binding site [chemical binding]; other site 234267012254 Uncharacterized conserved protein [Function unknown]; Region: COG1872 234267012255 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234267012256 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 234267012257 active site 234267012258 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 234267012259 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012260 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267012261 YceI-like domain; Region: YceI; pfam04264 234267012262 Phosphoglycerate kinase; Region: PGK; pfam00162 234267012263 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 234267012264 substrate binding site [chemical binding]; other site 234267012265 hinge regions; other site 234267012266 ADP binding site [chemical binding]; other site 234267012267 catalytic site [active] 234267012268 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 234267012269 Strictosidine synthase; Region: Str_synth; pfam03088 234267012270 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267012271 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267012272 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267012273 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267012274 DNA binding residues [nucleotide binding] 234267012275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267012276 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267012277 S-adenosylmethionine binding site [chemical binding]; other site 234267012278 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 234267012279 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 234267012280 Walker A/P-loop; other site 234267012281 ATP binding site [chemical binding]; other site 234267012282 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 234267012283 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 234267012284 ABC transporter signature motif; other site 234267012285 Walker B; other site 234267012286 D-loop; other site 234267012287 H-loop/switch region; other site 234267012288 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234267012289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234267012290 substrate binding site [chemical binding]; other site 234267012291 oxyanion hole (OAH) forming residues; other site 234267012292 trimer interface [polypeptide binding]; other site 234267012293 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234267012294 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 234267012295 NodB motif; other site 234267012296 active site 234267012297 catalytic site [active] 234267012298 metal binding site [ion binding]; metal-binding site 234267012299 Caspase domain; Region: Peptidase_C14; pfam00656 234267012300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012301 TPR motif; other site 234267012302 binding surface 234267012303 TPR repeat; Region: TPR_11; pfam13414 234267012304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267012305 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267012306 active site 234267012307 ATP binding site [chemical binding]; other site 234267012308 substrate binding site [chemical binding]; other site 234267012309 activation loop (A-loop); other site 234267012310 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267012311 structural tetrad; other site 234267012312 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267012313 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267012314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267012315 Walker A/P-loop; other site 234267012316 ATP binding site [chemical binding]; other site 234267012317 Q-loop/lid; other site 234267012318 ABC transporter signature motif; other site 234267012319 Walker B; other site 234267012320 D-loop; other site 234267012321 H-loop/switch region; other site 234267012322 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 234267012323 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 234267012324 Clp amino terminal domain; Region: Clp_N; pfam02861 234267012325 Clp amino terminal domain; Region: Clp_N; pfam02861 234267012326 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267012327 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267012328 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012329 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012330 FtsX-like permease family; Region: FtsX; pfam02687 234267012331 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012332 FtsX-like permease family; Region: FtsX; pfam02687 234267012333 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267012334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267012335 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 234267012336 substrate binding site [chemical binding]; other site 234267012337 active site 234267012338 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012339 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012341 FtsX-like permease family; Region: FtsX; pfam02687 234267012342 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 234267012343 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 234267012344 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 234267012345 catalytic triad [active] 234267012346 argininosuccinate synthase; Validated; Region: PRK05370 234267012347 argininosuccinate synthase; Provisional; Region: PRK13820 234267012348 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012349 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267012350 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267012351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267012352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267012353 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267012354 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267012355 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267012356 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 234267012357 metal binding site [ion binding]; metal-binding site 234267012358 substrate binding pocket [chemical binding]; other site 234267012359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267012360 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267012361 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267012362 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 234267012363 Prostaglandin dehydrogenases; Region: PGDH; cd05288 234267012364 NAD(P) binding site [chemical binding]; other site 234267012365 substrate binding site [chemical binding]; other site 234267012366 dimer interface [polypeptide binding]; other site 234267012367 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 234267012368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267012369 motif II; other site 234267012370 putative aminotransferase; Provisional; Region: PRK09105 234267012371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267012372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267012373 homodimer interface [polypeptide binding]; other site 234267012374 catalytic residue [active] 234267012375 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234267012376 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234267012377 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234267012378 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012379 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267012380 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 234267012381 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 234267012382 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267012383 GAF domain; Region: GAF; pfam01590 234267012384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267012385 GAF domain; Region: GAF; pfam01590 234267012386 ANTAR domain; Region: ANTAR; pfam03861 234267012387 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 234267012388 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 234267012389 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267012390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267012391 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267012392 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267012393 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 234267012394 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 234267012395 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 234267012396 oligomer interface [polypeptide binding]; other site 234267012397 active site 234267012398 metal binding site [ion binding]; metal-binding site 234267012399 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267012400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267012401 S-adenosylmethionine binding site [chemical binding]; other site 234267012402 Flagellin N-methylase; Region: FliB; cl00497 234267012403 Radical SAM superfamily; Region: Radical_SAM; pfam04055 234267012404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267012405 FeS/SAM binding site; other site 234267012406 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267012407 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012408 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267012409 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 234267012410 short chain dehydrogenase; Provisional; Region: PRK06500 234267012411 classical (c) SDRs; Region: SDR_c; cd05233 234267012412 NAD(P) binding site [chemical binding]; other site 234267012413 active site 234267012414 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 234267012415 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 234267012416 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 234267012417 short chain dehydrogenase; Provisional; Region: PRK06500 234267012418 classical (c) SDRs; Region: SDR_c; cd05233 234267012419 NAD(P) binding site [chemical binding]; other site 234267012420 active site 234267012421 Cupin; Region: Cupin_6; pfam12852 234267012422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267012423 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234267012424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267012425 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267012426 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267012427 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234267012428 active site 234267012429 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 234267012430 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234267012431 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 234267012432 active site 234267012433 catalytic triad [active] 234267012434 dimer interface [polypeptide binding]; other site 234267012435 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 234267012436 FAD binding domain; Region: FAD_binding_4; pfam01565 234267012437 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 234267012438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 234267012439 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 234267012440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267012441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267012442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267012443 Walker A/P-loop; other site 234267012444 ATP binding site [chemical binding]; other site 234267012445 Q-loop/lid; other site 234267012446 ABC transporter signature motif; other site 234267012447 Walker B; other site 234267012448 D-loop; other site 234267012449 H-loop/switch region; other site 234267012450 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012452 FtsX-like permease family; Region: FtsX; pfam02687 234267012453 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012454 FtsX-like permease family; Region: FtsX; pfam02687 234267012455 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 234267012456 DEAD/DEAH box helicase; Region: DEAD; pfam00270 234267012457 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 234267012458 SEC-C motif; Region: SEC-C; pfam02810 234267012459 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267012460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234267012461 DNA binding residues [nucleotide binding] 234267012462 DinB superfamily; Region: DinB_2; pfam12867 234267012463 DinB family; Region: DinB; cl17821 234267012464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267012465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267012466 active site 234267012467 ATP binding site [chemical binding]; other site 234267012468 substrate binding site [chemical binding]; other site 234267012469 activation loop (A-loop); other site 234267012470 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267012471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012472 TPR motif; other site 234267012473 binding surface 234267012474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012475 TPR motif; other site 234267012476 binding surface 234267012477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012478 TPR motif; other site 234267012479 binding surface 234267012480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267012481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267012482 NAD(P) binding site [chemical binding]; other site 234267012483 active site 234267012484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267012485 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 234267012486 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 234267012487 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 234267012488 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 234267012489 active site 234267012490 catalytic site [active] 234267012491 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 234267012492 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267012493 TPR repeat; Region: TPR_11; pfam13414 234267012494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012495 binding surface 234267012496 TPR motif; other site 234267012497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012498 TPR motif; other site 234267012499 binding surface 234267012500 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 234267012501 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267012502 methionine sulfoxide reductase A; Provisional; Region: PRK14054 234267012503 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 234267012504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267012505 Walker A/P-loop; other site 234267012506 ATP binding site [chemical binding]; other site 234267012507 Q-loop/lid; other site 234267012508 ABC transporter signature motif; other site 234267012509 Walker B; other site 234267012510 D-loop; other site 234267012511 H-loop/switch region; other site 234267012512 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 234267012513 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234267012514 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 234267012515 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 234267012516 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 234267012517 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 234267012518 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 234267012519 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 234267012520 active site 234267012521 Isochorismatase family; Region: Isochorismatase; pfam00857 234267012522 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 234267012523 catalytic triad [active] 234267012524 conserved cis-peptide bond; other site 234267012525 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 234267012526 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 234267012527 NAD(P) binding site [chemical binding]; other site 234267012528 Methylamine utilisation protein MauE; Region: MauE; pfam07291 234267012529 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 234267012530 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 234267012531 catalytic residues [active] 234267012532 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 234267012533 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 234267012534 catalytic residues [active] 234267012535 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267012536 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 234267012537 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012539 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012540 FtsX-like permease family; Region: FtsX; pfam02687 234267012541 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 234267012542 dimer interface [polypeptide binding]; other site 234267012543 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012544 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012545 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012546 FtsX-like permease family; Region: FtsX; pfam02687 234267012547 Alginate lyase; Region: Alginate_lyase; pfam05426 234267012548 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267012549 YWTD domain; Region: YWTD; pfam13570 234267012550 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267012551 Trp docking motif [polypeptide binding]; other site 234267012552 active site 234267012553 PQQ-like domain; Region: PQQ_2; pfam13360 234267012554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267012555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267012556 active site 234267012557 ATP binding site [chemical binding]; other site 234267012558 substrate binding site [chemical binding]; other site 234267012559 activation loop (A-loop); other site 234267012560 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267012561 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267012562 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267012563 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 234267012564 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267012565 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 234267012566 Malic enzyme, N-terminal domain; Region: malic; pfam00390 234267012567 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 234267012568 putative NAD(P) binding site [chemical binding]; other site 234267012569 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 234267012570 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 234267012571 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234267012572 metal ion-dependent adhesion site (MIDAS); other site 234267012573 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 234267012574 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267012575 metal ion-dependent adhesion site (MIDAS); other site 234267012576 TadE-like protein; Region: TadE; pfam07811 234267012577 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 234267012578 TadE-like protein; Region: TadE; pfam07811 234267012579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267012580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267012581 NAD(P) binding site [chemical binding]; other site 234267012582 active site 234267012583 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 234267012584 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 234267012585 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 234267012586 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 234267012587 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234267012588 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267012589 Catalytic site [active] 234267012590 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267012591 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 234267012592 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 234267012593 Substrate binding site; other site 234267012594 Cupin domain; Region: Cupin_2; cl17218 234267012595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012596 binding surface 234267012597 TPR motif; other site 234267012598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012599 binding surface 234267012600 TPR motif; other site 234267012601 TPR repeat; Region: TPR_11; pfam13414 234267012602 TPR repeat; Region: TPR_11; pfam13414 234267012603 TPR repeat; Region: TPR_11; pfam13414 234267012604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012605 binding surface 234267012606 TPR motif; other site 234267012607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012608 TPR motif; other site 234267012609 TPR repeat; Region: TPR_11; pfam13414 234267012610 binding surface 234267012611 TPR repeat; Region: TPR_11; pfam13414 234267012612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012613 binding surface 234267012614 TPR motif; other site 234267012615 TPR repeat; Region: TPR_11; pfam13414 234267012616 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234267012617 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 234267012618 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267012619 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267012620 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267012621 PilZ domain; Region: PilZ; pfam07238 234267012622 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 234267012623 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267012624 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234267012625 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267012626 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267012627 benzoate transport; Region: 2A0115; TIGR00895 234267012628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267012629 putative substrate translocation pore; other site 234267012630 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267012631 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267012632 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267012633 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267012634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012635 binding surface 234267012636 TPR motif; other site 234267012637 TPR repeat; Region: TPR_11; pfam13414 234267012638 TPR repeat; Region: TPR_11; pfam13414 234267012639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012640 binding surface 234267012641 TPR motif; other site 234267012642 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267012643 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012644 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267012645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267012646 BON domain; Region: BON; pfam04972 234267012647 BON domain; Region: BON; pfam04972 234267012648 phage shock protein A; Region: phageshock_pspA; TIGR02977 234267012649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 234267012650 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 234267012651 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 234267012652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234267012653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267012654 non-specific DNA binding site [nucleotide binding]; other site 234267012655 salt bridge; other site 234267012656 sequence-specific DNA binding site [nucleotide binding]; other site 234267012657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267012658 dimerization interface [polypeptide binding]; other site 234267012659 putative DNA binding site [nucleotide binding]; other site 234267012660 putative Zn2+ binding site [ion binding]; other site 234267012661 NIPSNAP; Region: NIPSNAP; pfam07978 234267012662 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267012663 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 234267012664 Cytochrome c; Region: Cytochrom_C; cl11414 234267012665 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267012666 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267012667 Trp docking motif [polypeptide binding]; other site 234267012668 active site 234267012669 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267012670 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012671 FtsX-like permease family; Region: FtsX; pfam02687 234267012672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267012673 FtsX-like permease family; Region: FtsX; pfam02687 234267012674 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267012675 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267012676 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267012677 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 234267012678 apical/protease domain interface [polypeptide binding]; other site 234267012679 substrate binding [chemical binding]; other site 234267012680 dimer interface [polypeptide binding]; other site 234267012681 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 234267012682 dimer interface [polypeptide binding]; other site 234267012683 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267012684 active site 234267012685 metal binding site [ion binding]; metal-binding site 234267012686 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 234267012687 Response regulator receiver domain; Region: Response_reg; pfam00072 234267012688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267012689 active site 234267012690 dimerization interface [polypeptide binding]; other site 234267012691 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 234267012692 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 234267012693 catalytic triad [active] 234267012694 AMIN domain; Region: AMIN; pfam11741 234267012695 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 234267012696 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 234267012697 active site 234267012698 metal binding site [ion binding]; metal-binding site 234267012699 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234267012700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267012701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267012702 catalytic residue [active] 234267012703 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 234267012704 GTP binding site; other site 234267012705 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 234267012706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267012707 Walker A/P-loop; other site 234267012708 ATP binding site [chemical binding]; other site 234267012709 Q-loop/lid; other site 234267012710 ABC transporter signature motif; other site 234267012711 Walker B; other site 234267012712 D-loop; other site 234267012713 H-loop/switch region; other site 234267012714 metal-dependent hydrolase; Provisional; Region: PRK13291 234267012715 DinB superfamily; Region: DinB_2; pfam12867 234267012716 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 234267012717 active site 234267012718 dinuclear metal binding site [ion binding]; other site 234267012719 dimerization interface [polypeptide binding]; other site 234267012720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267012721 D-galactonate transporter; Region: 2A0114; TIGR00893 234267012722 putative substrate translocation pore; other site 234267012723 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234267012724 MarR family; Region: MarR_2; pfam12802 234267012725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267012726 phosphorylation site [posttranslational modification] 234267012727 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 234267012728 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234267012729 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234267012730 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 234267012731 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 234267012732 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 234267012733 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 234267012734 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 234267012735 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 234267012736 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267012737 substrate binding site [chemical binding]; other site 234267012738 ATP binding site [chemical binding]; other site 234267012739 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 234267012740 Beta-propeller repeat; Region: SBBP; pfam06739 234267012741 Beta-propeller repeat; Region: SBBP; pfam06739 234267012742 Beta-propeller repeat; Region: SBBP; pfam06739 234267012743 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267012744 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012745 BNR repeat-like domain; Region: BNR_2; pfam13088 234267012746 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 234267012747 Asp-box motif; other site 234267012748 catalytic site [active] 234267012749 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 234267012750 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267012751 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267012752 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267012753 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 234267012754 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 234267012755 active site 234267012756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 234267012757 putative dimer interface [polypeptide binding]; other site 234267012758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267012759 Helix-turn-helix domain; Region: HTH_18; pfam12833 234267012760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267012761 D-glutamate deacylase; Validated; Region: PRK09061 234267012762 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267012763 active site 234267012764 Methyltransferase domain; Region: Methyltransf_12; pfam08242 234267012765 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 234267012766 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267012767 Coenzyme A binding pocket [chemical binding]; other site 234267012768 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267012769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267012770 putative substrate translocation pore; other site 234267012771 Response regulator receiver domain; Region: Response_reg; pfam00072 234267012772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267012773 active site 234267012774 phosphorylation site [posttranslational modification] 234267012775 intermolecular recognition site; other site 234267012776 dimerization interface [polypeptide binding]; other site 234267012777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234267012778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234267012779 metal binding site [ion binding]; metal-binding site 234267012780 active site 234267012781 I-site; other site 234267012782 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 234267012783 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 234267012784 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 234267012785 active site 234267012786 NTP binding site [chemical binding]; other site 234267012787 metal binding triad [ion binding]; metal-binding site 234267012788 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 234267012789 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234267012790 Zn2+ binding site [ion binding]; other site 234267012791 Mg2+ binding site [ion binding]; other site 234267012792 Amino acid permease; Region: AA_permease_2; pfam13520 234267012793 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 234267012794 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 234267012795 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234267012796 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267012797 Asp-box motif; other site 234267012798 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 234267012799 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 234267012800 active site 234267012801 dimer interface [polypeptide binding]; other site 234267012802 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 234267012803 Ligand Binding Site [chemical binding]; other site 234267012804 Molecular Tunnel; other site 234267012805 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267012806 Winged helix-turn helix; Region: HTH_29; pfam13551 234267012807 DNA-binding interface [nucleotide binding]; DNA binding site 234267012808 Homeodomain-like domain; Region: HTH_32; pfam13565 234267012809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267012810 Integrase core domain; Region: rve; pfam00665 234267012811 Integrase core domain; Region: rve_3; pfam13683 234267012812 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267012813 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267012814 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267012815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234267012816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234267012817 metal binding site [ion binding]; metal-binding site 234267012818 active site 234267012819 I-site; other site 234267012820 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267012821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267012822 putative active site [active] 234267012823 heme pocket [chemical binding]; other site 234267012824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267012825 dimer interface [polypeptide binding]; other site 234267012826 phosphorylation site [posttranslational modification] 234267012827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267012828 ATP binding site [chemical binding]; other site 234267012829 Mg2+ binding site [ion binding]; other site 234267012830 G-X-G motif; other site 234267012831 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267012832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267012833 active site 234267012834 phosphorylation site [posttranslational modification] 234267012835 intermolecular recognition site; other site 234267012836 dimerization interface [polypeptide binding]; other site 234267012837 Response regulator receiver domain; Region: Response_reg; pfam00072 234267012838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267012839 active site 234267012840 phosphorylation site [posttranslational modification] 234267012841 intermolecular recognition site; other site 234267012842 dimerization interface [polypeptide binding]; other site 234267012843 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267012844 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 234267012845 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 234267012846 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 234267012847 NADP binding site [chemical binding]; other site 234267012848 active site 234267012849 putative substrate binding site [chemical binding]; other site 234267012850 GDP-mannose 4,6-dehydratase; Region: PLN02653 234267012851 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 234267012852 NADP-binding site; other site 234267012853 homotetramer interface [polypeptide binding]; other site 234267012854 substrate binding site [chemical binding]; other site 234267012855 homodimer interface [polypeptide binding]; other site 234267012856 active site 234267012857 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 234267012858 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267012859 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267012860 Ligand binding site; other site 234267012861 Putative Catalytic site; other site 234267012862 DXD motif; other site 234267012863 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 234267012864 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 234267012865 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 234267012866 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 234267012867 SLBB domain; Region: SLBB; pfam10531 234267012868 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 234267012869 Chain length determinant protein; Region: Wzz; pfam02706 234267012870 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 234267012871 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267012872 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234267012873 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267012874 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 234267012875 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 234267012876 Walker A/P-loop; other site 234267012877 ATP binding site [chemical binding]; other site 234267012878 Q-loop/lid; other site 234267012879 ABC transporter signature motif; other site 234267012880 Walker B; other site 234267012881 D-loop; other site 234267012882 H-loop/switch region; other site 234267012883 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 234267012884 putative carbohydrate binding site [chemical binding]; other site 234267012885 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267012886 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234267012887 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 234267012888 inhibitor-cofactor binding pocket; inhibition site 234267012889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267012890 catalytic residue [active] 234267012891 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267012892 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267012893 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234267012894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267012895 active site 234267012896 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 234267012897 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 234267012898 trimer interface [polypeptide binding]; other site 234267012899 active site 234267012900 substrate binding site [chemical binding]; other site 234267012901 CoA binding site [chemical binding]; other site 234267012902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267012903 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234267012904 active site 234267012905 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267012906 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 234267012907 active site 234267012908 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 234267012909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267012910 active site 234267012911 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267012912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267012913 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 234267012914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267012915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267012916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267012917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267012918 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267012919 putative acyl transferase; Provisional; Region: PRK10502 234267012920 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 234267012921 putative trimer interface [polypeptide binding]; other site 234267012922 putative active site [active] 234267012923 putative substrate binding site [chemical binding]; other site 234267012924 putative CoA binding site [chemical binding]; other site 234267012925 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 234267012926 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 234267012927 Mg++ binding site [ion binding]; other site 234267012928 putative catalytic motif [active] 234267012929 substrate binding site [chemical binding]; other site 234267012930 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267012931 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 234267012932 transcriptional activator RfaH; Region: RfaH; TIGR01955 234267012933 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 234267012934 heterodimer interface [polypeptide binding]; other site 234267012935 homodimer interface [polypeptide binding]; other site 234267012936 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 234267012937 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 234267012938 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 234267012939 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267012940 TPR repeat; Region: TPR_11; pfam13414 234267012941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012942 binding surface 234267012943 TPR motif; other site 234267012944 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 234267012945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012946 TPR motif; other site 234267012947 binding surface 234267012948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012949 binding surface 234267012950 TPR motif; other site 234267012951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012952 binding surface 234267012953 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267012954 TPR motif; other site 234267012955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012956 binding surface 234267012957 TPR motif; other site 234267012958 TPR repeat; Region: TPR_11; pfam13414 234267012959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012960 TPR motif; other site 234267012961 binding surface 234267012962 TPR repeat; Region: TPR_11; pfam13414 234267012963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012964 binding surface 234267012965 TPR motif; other site 234267012966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012967 binding surface 234267012968 TPR motif; other site 234267012969 TPR repeat; Region: TPR_11; pfam13414 234267012970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012971 binding surface 234267012972 TPR motif; other site 234267012973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012974 TPR motif; other site 234267012975 TPR repeat; Region: TPR_11; pfam13414 234267012976 binding surface 234267012977 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234267012978 putative active site [active] 234267012979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012980 binding surface 234267012981 TPR repeat; Region: TPR_11; pfam13414 234267012982 TPR motif; other site 234267012983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012984 TPR motif; other site 234267012985 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267012986 binding surface 234267012987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012988 binding surface 234267012989 TPR motif; other site 234267012990 TPR repeat; Region: TPR_11; pfam13414 234267012991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012992 binding surface 234267012993 TPR motif; other site 234267012994 TPR repeat; Region: TPR_11; pfam13414 234267012995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267012996 binding surface 234267012997 TPR motif; other site 234267012998 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 234267012999 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234267013000 NAD binding site [chemical binding]; other site 234267013001 substrate binding site [chemical binding]; other site 234267013002 putative active site [active] 234267013003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267013004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267013005 Protein of unknown function, DUF488; Region: DUF488; cl01246 234267013006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 234267013007 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 234267013008 OPT oligopeptide transporter protein; Region: OPT; cl14607 234267013009 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 234267013010 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013011 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267013012 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013013 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013014 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013015 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267013016 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267013017 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 234267013018 active site 234267013019 Int/Topo IB signature motif; other site 234267013020 DNA binding site [nucleotide binding] 234267013021 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267013022 anti sigma factor interaction site; other site 234267013023 regulatory phosphorylation site [posttranslational modification]; other site 234267013024 Protein of unknown function DUF72; Region: DUF72; pfam01904 234267013025 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 234267013026 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 234267013027 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013028 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 234267013029 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013030 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013031 FtsX-like permease family; Region: FtsX; pfam02687 234267013032 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013033 FtsX-like permease family; Region: FtsX; pfam02687 234267013034 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013035 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013036 FtsX-like permease family; Region: FtsX; pfam02687 234267013037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013038 FtsX-like permease family; Region: FtsX; pfam02687 234267013039 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013040 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267013041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267013042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267013043 Amidohydrolase; Region: Amidohydro_4; pfam13147 234267013044 active site 234267013045 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 234267013046 lipoyl synthase; Provisional; Region: PRK05481 234267013047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267013048 FeS/SAM binding site; other site 234267013049 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 234267013050 EamA-like transporter family; Region: EamA; pfam00892 234267013051 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 234267013052 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 234267013053 MOSC domain; Region: MOSC; pfam03473 234267013054 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 234267013055 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 234267013056 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 234267013057 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267013058 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267013059 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267013060 glycerate dehydrogenase; Provisional; Region: PRK06487 234267013061 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 234267013062 putative ligand binding site [chemical binding]; other site 234267013063 putative NAD binding site [chemical binding]; other site 234267013064 catalytic site [active] 234267013065 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 234267013066 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 234267013067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267013068 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267013069 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 234267013070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267013071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267013072 FkbH-like domain; Region: FkbH; TIGR01686 234267013073 Acid Phosphatase; Region: Acid_PPase; cl17256 234267013074 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234267013075 Chorismate mutase type II; Region: CM_2; cl00693 234267013076 DinB superfamily; Region: DinB_2; pfam12867 234267013077 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234267013078 hydrophobic ligand binding site; other site 234267013079 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013080 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267013081 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 234267013082 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234267013083 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 234267013084 active site 234267013085 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 234267013086 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 234267013087 active site 234267013088 Zn binding site [ion binding]; other site 234267013089 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 234267013090 active site 234267013091 dimer interface [polypeptide binding]; other site 234267013092 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 234267013093 dimerization interface [polypeptide binding]; other site 234267013094 putative ATP binding site [chemical binding]; other site 234267013095 Phospholipase B; Region: Phospholip_B; pfam04916 234267013096 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267013097 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267013098 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 234267013099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267013100 TPR repeat; Region: TPR_11; pfam13414 234267013101 TPR motif; other site 234267013102 putative transposase OrfB; Reviewed; Region: PHA02517 234267013103 HTH-like domain; Region: HTH_21; pfam13276 234267013104 Integrase core domain; Region: rve; pfam00665 234267013105 Integrase core domain; Region: rve_3; pfam13683 234267013106 Transposase; Region: HTH_Tnp_1; cl17663 234267013107 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267013108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267013109 TPR motif; other site 234267013110 TPR repeat; Region: TPR_11; pfam13414 234267013111 binding surface 234267013112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267013113 binding surface 234267013114 TPR motif; other site 234267013115 TPR repeat; Region: TPR_11; pfam13414 234267013116 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267013117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234267013118 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267013119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267013120 S-adenosylmethionine binding site [chemical binding]; other site 234267013121 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 234267013122 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 234267013123 active site 234267013124 ADP/pyrophosphate binding site [chemical binding]; other site 234267013125 dimerization interface [polypeptide binding]; other site 234267013126 allosteric effector site; other site 234267013127 fructose-1,6-bisphosphate binding site; other site 234267013128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013129 intermolecular recognition site; other site 234267013130 active site 234267013131 dimerization interface [polypeptide binding]; other site 234267013132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 234267013133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267013134 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267013135 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267013136 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 234267013137 periplasmic chaperone; Provisional; Region: PRK10780 234267013138 O-Antigen ligase; Region: Wzy_C; pfam04932 234267013139 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 234267013140 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 234267013141 TIGR03118 family protein; Region: PEPCTERM_chp_1 234267013142 Cytochrome c; Region: Cytochrom_C; cl11414 234267013143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267013144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267013145 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267013146 Cupin domain; Region: Cupin_2; pfam07883 234267013147 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 234267013148 Putative transposase; Region: Y2_Tnp; pfam04986 234267013149 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 234267013150 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267013151 active site 234267013152 DNA binding site [nucleotide binding] 234267013153 Int/Topo IB signature motif; other site 234267013154 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267013155 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013156 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013158 FtsX-like permease family; Region: FtsX; pfam02687 234267013159 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013160 FtsX-like permease family; Region: FtsX; pfam02687 234267013161 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 234267013162 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 234267013163 motif 1; other site 234267013164 active site 234267013165 motif 2; other site 234267013166 motif 3; other site 234267013167 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 234267013168 DHHA1 domain; Region: DHHA1; pfam02272 234267013169 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 234267013170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234267013171 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 234267013172 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 234267013173 MutS domain I; Region: MutS_I; pfam01624 234267013174 MutS domain II; Region: MutS_II; pfam05188 234267013175 MutS domain III; Region: MutS_III; pfam05192 234267013176 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 234267013177 Walker A/P-loop; other site 234267013178 ATP binding site [chemical binding]; other site 234267013179 Q-loop/lid; other site 234267013180 ABC transporter signature motif; other site 234267013181 Walker B; other site 234267013182 D-loop; other site 234267013183 H-loop/switch region; other site 234267013184 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 234267013185 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 234267013186 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 234267013187 NAD(P) binding site [chemical binding]; other site 234267013188 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 234267013189 C factor cell-cell signaling protein; Provisional; Region: PRK09009 234267013190 NADP binding site [chemical binding]; other site 234267013191 substrate binding site [chemical binding]; other site 234267013192 active site 234267013193 Protein of unknown function (DUF419); Region: DUF419; pfam04237 234267013194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267013195 D-galactonate transporter; Region: 2A0114; TIGR00893 234267013196 putative substrate translocation pore; other site 234267013197 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 234267013198 Phosphotransferase enzyme family; Region: APH; pfam01636 234267013199 active site 234267013200 ATP binding site [chemical binding]; other site 234267013201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267013202 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267013203 substrate binding site [chemical binding]; other site 234267013204 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 234267013205 Right handed beta helix region; Region: Beta_helix; pfam13229 234267013206 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267013207 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013208 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013209 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013210 FtsX-like permease family; Region: FtsX; pfam02687 234267013211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013212 FtsX-like permease family; Region: FtsX; pfam02687 234267013213 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 234267013214 Domain of unknown function DUF11; Region: DUF11; cl17728 234267013215 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013216 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013217 FtsX-like permease family; Region: FtsX; pfam02687 234267013218 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013219 FtsX-like permease family; Region: FtsX; pfam02687 234267013220 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 234267013221 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 234267013222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267013223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267013224 dimer interface [polypeptide binding]; other site 234267013225 phosphorylation site [posttranslational modification] 234267013226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267013227 ATP binding site [chemical binding]; other site 234267013228 Mg2+ binding site [ion binding]; other site 234267013229 G-X-G motif; other site 234267013230 Response regulator receiver domain; Region: Response_reg; pfam00072 234267013231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013232 active site 234267013233 phosphorylation site [posttranslational modification] 234267013234 intermolecular recognition site; other site 234267013235 dimerization interface [polypeptide binding]; other site 234267013236 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 234267013237 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 234267013238 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 234267013239 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 234267013240 homodimer interface [polypeptide binding]; other site 234267013241 NADP binding site [chemical binding]; other site 234267013242 substrate binding site [chemical binding]; other site 234267013243 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 234267013244 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 234267013245 CoA-binding site [chemical binding]; other site 234267013246 ATP-binding [chemical binding]; other site 234267013247 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267013248 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267013249 protein binding site [polypeptide binding]; other site 234267013250 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 234267013251 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 234267013252 Na binding site [ion binding]; other site 234267013253 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 234267013254 PilZ domain; Region: PilZ; pfam07238 234267013255 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 234267013256 oligomerisation interface [polypeptide binding]; other site 234267013257 mobile loop; other site 234267013258 roof hairpin; other site 234267013259 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 234267013260 periplasmic chaperone; Provisional; Region: PRK10780 234267013261 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 234267013262 dimer interface [polypeptide binding]; other site 234267013263 Citrate synthase; Region: Citrate_synt; pfam00285 234267013264 active site 234267013265 citrylCoA binding site [chemical binding]; other site 234267013266 oxalacetate/citrate binding site [chemical binding]; other site 234267013267 coenzyme A binding site [chemical binding]; other site 234267013268 catalytic triad [active] 234267013269 methionine gamma-lyase; Validated; Region: PRK07049 234267013270 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234267013271 homodimer interface [polypeptide binding]; other site 234267013272 substrate-cofactor binding pocket; other site 234267013273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267013274 catalytic residue [active] 234267013275 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013276 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013277 FtsX-like permease family; Region: FtsX; pfam02687 234267013278 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013279 FtsX-like permease family; Region: FtsX; pfam02687 234267013280 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267013281 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013282 Predicted membrane protein [Function unknown]; Region: COG4485 234267013283 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234267013284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267013285 catalytic loop [active] 234267013286 iron binding site [ion binding]; other site 234267013287 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267013288 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267013289 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267013290 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267013291 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267013292 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267013293 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 234267013294 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234267013295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267013296 DNA-binding site [nucleotide binding]; DNA binding site 234267013297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267013298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267013299 homodimer interface [polypeptide binding]; other site 234267013300 catalytic residue [active] 234267013301 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267013302 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 234267013303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267013304 catalytic residue [active] 234267013305 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 234267013306 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 234267013307 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 234267013308 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267013309 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 234267013310 substrate binding site [chemical binding]; other site 234267013311 ATP binding site [chemical binding]; other site 234267013312 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 234267013313 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234267013314 active site 234267013315 catalytic site [active] 234267013316 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267013317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267013318 Condensation domain; Region: Condensation; pfam00668 234267013319 FkbH-like domain; Region: FkbH; TIGR01686 234267013320 Acid Phosphatase; Region: Acid_PPase; cl17256 234267013321 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267013322 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267013323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267013324 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267013325 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267013326 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267013327 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267013328 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267013329 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267013330 Penicillinase repressor; Region: Pencillinase_R; cl17580 234267013331 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 234267013332 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234267013333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267013334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267013335 catalytic residue [active] 234267013336 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234267013337 HI0933-like protein; Region: HI0933_like; pfam03486 234267013338 intracellular protease, PfpI family; Region: PfpI; TIGR01382 234267013339 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 234267013340 conserved cys residue [active] 234267013341 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 234267013342 active site 234267013343 catalytic residues [active] 234267013344 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267013345 active site 234267013346 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 234267013347 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 234267013348 active site 234267013349 (T/H)XGH motif; other site 234267013350 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267013351 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 234267013352 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 234267013353 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234267013354 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267013355 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267013356 metal ion-dependent adhesion site (MIDAS); other site 234267013357 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267013358 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267013359 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 234267013360 Fe-S cluster binding site [ion binding]; other site 234267013361 DNA binding site [nucleotide binding] 234267013362 active site 234267013363 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 234267013364 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234267013365 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267013366 Catalytic site [active] 234267013367 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234267013368 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267013369 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013370 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267013371 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267013372 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 234267013373 substrate binding site [chemical binding]; other site 234267013374 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 234267013375 active site 234267013376 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 234267013377 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 234267013378 active site 234267013379 Zn binding site [ion binding]; other site 234267013380 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 234267013381 homotrimer interaction site [polypeptide binding]; other site 234267013382 putative active site [active] 234267013383 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234267013384 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267013385 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267013386 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267013387 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267013388 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 234267013389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267013390 FeS/SAM binding site; other site 234267013391 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 234267013392 Domain of unknown function (DUF202); Region: DUF202; pfam02656 234267013393 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267013394 Sulfatase; Region: Sulfatase; pfam00884 234267013395 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 234267013396 Chain length determinant protein; Region: Wzz; cl15801 234267013397 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 234267013398 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267013399 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 234267013400 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 234267013401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267013402 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 234267013403 putative ADP-binding pocket [chemical binding]; other site 234267013404 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234267013405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267013406 Coenzyme A binding pocket [chemical binding]; other site 234267013407 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234267013408 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 234267013409 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234267013410 inhibitor-cofactor binding pocket; inhibition site 234267013411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267013412 catalytic residue [active] 234267013413 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 234267013414 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 234267013415 NAD(P) binding site [chemical binding]; other site 234267013416 homodimer interface [polypeptide binding]; other site 234267013417 substrate binding site [chemical binding]; other site 234267013418 active site 234267013419 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 234267013420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267013421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267013422 catalytic residue [active] 234267013423 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 234267013424 putative active site [active] 234267013425 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 234267013426 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 234267013427 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 234267013428 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 234267013429 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 234267013430 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 234267013431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267013432 substrate binding pocket [chemical binding]; other site 234267013433 membrane-bound complex binding site; other site 234267013434 hinge residues; other site 234267013435 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267013436 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267013437 catalytic residue [active] 234267013438 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 234267013439 amphipathic channel; other site 234267013440 Asn-Pro-Ala signature motifs; other site 234267013441 Predicted membrane protein [Function unknown]; Region: COG2261 234267013442 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 234267013443 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 234267013444 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 234267013445 Predicted membrane protein [Function unknown]; Region: COG2261 234267013446 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 234267013447 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 234267013448 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234267013449 Nucleotide binding site [chemical binding]; other site 234267013450 DTAP/Switch II; other site 234267013451 Switch I; other site 234267013452 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 234267013453 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 234267013454 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 234267013455 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267013456 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 234267013457 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267013458 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 234267013459 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 234267013460 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 234267013461 putative outer membrane lipoprotein; Provisional; Region: PRK09967 234267013462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267013463 ligand binding site [chemical binding]; other site 234267013464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267013465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234267013466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267013467 Walker A/P-loop; other site 234267013468 ATP binding site [chemical binding]; other site 234267013469 Q-loop/lid; other site 234267013470 ABC transporter signature motif; other site 234267013471 Walker B; other site 234267013472 D-loop; other site 234267013473 H-loop/switch region; other site 234267013474 Predicted metalloprotease [General function prediction only]; Region: COG2321 234267013475 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 234267013476 Putative phosphatase (DUF442); Region: DUF442; cl17385 234267013477 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 234267013478 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 234267013479 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234267013480 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 234267013481 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234267013482 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 234267013483 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 234267013484 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267013485 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267013486 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267013487 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267013488 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 234267013489 active site 234267013490 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013491 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013493 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267013494 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267013495 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 234267013496 cyclase homology domain; Region: CHD; cd07302 234267013497 nucleotidyl binding site; other site 234267013498 metal binding site [ion binding]; metal-binding site 234267013499 dimer interface [polypeptide binding]; other site 234267013500 TIR domain; Region: TIR_2; pfam13676 234267013501 CAAX protease self-immunity; Region: Abi; pfam02517 234267013502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267013503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267013504 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267013505 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267013506 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267013507 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267013508 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267013509 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267013510 hypothetical protein; Provisional; Region: PHA02764 234267013511 amino acid transporter; Region: 2A0306; TIGR00909 234267013512 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 234267013513 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 234267013514 active site 234267013515 catalytic site [active] 234267013516 metal binding site [ion binding]; metal-binding site 234267013517 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267013518 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267013519 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267013520 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267013521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234267013522 active site 234267013523 KMSKS motif; other site 234267013524 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267013525 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267013526 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267013527 Trp docking motif [polypeptide binding]; other site 234267013528 putative active site [active] 234267013529 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267013530 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267013531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267013532 S-adenosylmethionine binding site [chemical binding]; other site 234267013533 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267013534 Penicillin amidase; Region: Penicil_amidase; pfam01804 234267013535 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267013536 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 234267013537 active site 234267013538 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267013539 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 234267013540 active site residue [active] 234267013541 putative phosphoketolase; Provisional; Region: PRK05261 234267013542 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 234267013543 TPP-binding site; other site 234267013544 XFP C-terminal domain; Region: XFP_C; pfam09363 234267013545 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 234267013546 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 234267013547 NAD binding site [chemical binding]; other site 234267013548 catalytic Zn binding site [ion binding]; other site 234267013549 structural Zn binding site [ion binding]; other site 234267013550 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 234267013551 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 234267013552 DinB superfamily; Region: DinB_2; pfam12867 234267013553 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 234267013554 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234267013555 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 234267013556 Domain of unknown function DUF21; Region: DUF21; pfam01595 234267013557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234267013558 Transporter associated domain; Region: CorC_HlyC; smart01091 234267013559 Penicillin amidase; Region: Penicil_amidase; pfam01804 234267013560 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267013561 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 234267013562 active site 234267013563 calcium/proton exchanger (cax); Region: cax; TIGR00378 234267013564 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 234267013565 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 234267013566 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 234267013567 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 234267013568 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267013569 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234267013570 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 234267013571 catalytic triad [active] 234267013572 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 234267013573 thiamine phosphate binding site [chemical binding]; other site 234267013574 active site 234267013575 pyrophosphate binding site [ion binding]; other site 234267013576 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234267013577 amino acid transporter; Region: 2A0306; TIGR00909 234267013578 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 234267013579 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 234267013580 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267013581 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267013582 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013584 FtsX-like permease family; Region: FtsX; pfam02687 234267013585 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013586 FtsX-like permease family; Region: FtsX; pfam02687 234267013587 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267013588 Amidase; Region: Amidase; pfam01425 234267013589 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 234267013590 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234267013591 hypothetical protein; Provisional; Region: PRK09133 234267013592 putative metal binding site [ion binding]; other site 234267013593 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 234267013594 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267013595 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 234267013596 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267013597 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267013598 protein binding site [polypeptide binding]; other site 234267013599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267013600 protein binding site [polypeptide binding]; other site 234267013601 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267013602 GAF domain; Region: GAF; pfam01590 234267013603 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267013604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267013605 putative active site [active] 234267013606 heme pocket [chemical binding]; other site 234267013607 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267013608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267013609 putative active site [active] 234267013610 heme pocket [chemical binding]; other site 234267013611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267013612 heme pocket [chemical binding]; other site 234267013613 putative active site [active] 234267013614 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267013615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267013616 putative active site [active] 234267013617 heme pocket [chemical binding]; other site 234267013618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267013619 dimer interface [polypeptide binding]; other site 234267013620 phosphorylation site [posttranslational modification] 234267013621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267013622 ATP binding site [chemical binding]; other site 234267013623 Mg2+ binding site [ion binding]; other site 234267013624 G-X-G motif; other site 234267013625 Response regulator receiver domain; Region: Response_reg; pfam00072 234267013626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013627 active site 234267013628 phosphorylation site [posttranslational modification] 234267013629 intermolecular recognition site; other site 234267013630 dimerization interface [polypeptide binding]; other site 234267013631 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 234267013632 putative ADP-ribose binding site [chemical binding]; other site 234267013633 putative active site [active] 234267013634 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267013635 LssY C-terminus; Region: LssY_C; pfam14067 234267013636 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267013637 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013638 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267013639 FtsX-like permease family; Region: FtsX; pfam02687 234267013640 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267013641 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267013642 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267013643 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 234267013644 Zn binding site [ion binding]; other site 234267013645 D-mannonate oxidoreductase; Provisional; Region: PRK08277 234267013646 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 234267013647 putative NAD(P) binding site [chemical binding]; other site 234267013648 active site 234267013649 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 234267013650 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234267013651 Protein of unknown function (DUF502); Region: DUF502; pfam04367 234267013652 Porin subfamily; Region: Porin_2; pfam02530 234267013653 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 234267013654 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 234267013655 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 234267013656 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 234267013657 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 234267013658 3D domain; Region: 3D; cl01439 234267013659 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 234267013660 ArsC family; Region: ArsC; pfam03960 234267013661 catalytic residue [active] 234267013662 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234267013663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234267013664 acyl-activating enzyme (AAE) consensus motif; other site 234267013665 AMP binding site [chemical binding]; other site 234267013666 active site 234267013667 CoA binding site [chemical binding]; other site 234267013668 L-lactate permease; Region: Lactate_perm; cl00701 234267013669 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 234267013670 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 234267013671 active site 234267013672 catalytic site [active] 234267013673 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 234267013674 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 234267013675 putative amphipathic alpha helix; other site 234267013676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267013677 non-specific DNA binding site [nucleotide binding]; other site 234267013678 salt bridge; other site 234267013679 sequence-specific DNA binding site [nucleotide binding]; other site 234267013680 Outer membrane efflux protein; Region: OEP; pfam02321 234267013681 Outer membrane efflux protein; Region: OEP; pfam02321 234267013682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267013683 active site 234267013684 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 234267013685 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 234267013686 dimerization interface 3.5A [polypeptide binding]; other site 234267013687 active site 234267013688 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 234267013689 A new structural DNA glycosylase; Region: AlkD_like; cd06561 234267013690 active site 234267013691 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 234267013692 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234267013693 NodB motif; other site 234267013694 putative active site [active] 234267013695 putative catalytic site [active] 234267013696 putative Zn binding site [ion binding]; other site 234267013697 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 234267013698 active site 234267013699 catalytic residues [active] 234267013700 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267013701 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267013702 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267013703 translocation protein TolB; Provisional; Region: tolB; PRK00178 234267013704 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267013705 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267013706 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267013707 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267013708 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 234267013709 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 234267013710 domain interfaces; other site 234267013711 active site 234267013712 Peptidase family M48; Region: Peptidase_M48; cl12018 234267013713 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267013714 putative active site [active] 234267013715 Zn binding site [ion binding]; other site 234267013716 PEP-CTERM motif; Region: VPEP; pfam07589 234267013717 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 234267013718 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 234267013719 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 234267013720 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 234267013721 putative dimer interface [polypeptide binding]; other site 234267013722 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267013723 BNR repeat-like domain; Region: BNR_2; pfam13088 234267013724 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267013725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267013726 Cytochrome c; Region: Cytochrom_C; pfam00034 234267013727 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267013728 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267013729 Trp docking motif [polypeptide binding]; other site 234267013730 active site 234267013731 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 234267013732 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234267013733 HIGH motif; other site 234267013734 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234267013735 active site 234267013736 KMSKS motif; other site 234267013737 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 234267013738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234267013739 active site 234267013740 HIGH motif; other site 234267013741 nucleotide binding site [chemical binding]; other site 234267013742 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 234267013743 KMSKS motif; other site 234267013744 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 234267013745 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 234267013746 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 234267013747 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 234267013748 nickel binding site [ion binding]; other site 234267013749 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 234267013750 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 234267013751 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 234267013752 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 234267013753 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267013754 catalytic loop [active] 234267013755 iron binding site [ion binding]; other site 234267013756 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 234267013757 4Fe-4S binding domain; Region: Fer4; pfam00037 234267013758 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 234267013759 dimer interface [polypeptide binding]; other site 234267013760 [2Fe-2S] cluster binding site [ion binding]; other site 234267013761 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 234267013762 SLBB domain; Region: SLBB; pfam10531 234267013763 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 234267013764 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 234267013765 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 234267013766 putative dimer interface [polypeptide binding]; other site 234267013767 [2Fe-2S] cluster binding site [ion binding]; other site 234267013768 PAS domain; Region: PAS; smart00091 234267013769 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267013770 putative active site [active] 234267013771 heme pocket [chemical binding]; other site 234267013772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267013773 dimer interface [polypeptide binding]; other site 234267013774 phosphorylation site [posttranslational modification] 234267013775 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234267013776 ATP binding site [chemical binding]; other site 234267013777 Mg2+ binding site [ion binding]; other site 234267013778 G-X-G motif; other site 234267013779 Response regulator receiver domain; Region: Response_reg; pfam00072 234267013780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013781 active site 234267013782 phosphorylation site [posttranslational modification] 234267013783 intermolecular recognition site; other site 234267013784 dimerization interface [polypeptide binding]; other site 234267013785 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267013786 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 234267013787 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 234267013788 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267013789 metal binding site [ion binding]; metal-binding site 234267013790 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 234267013791 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267013792 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267013793 active site 234267013794 ATP binding site [chemical binding]; other site 234267013795 substrate binding site [chemical binding]; other site 234267013796 activation loop (A-loop); other site 234267013797 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267013798 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267013799 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267013800 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267013801 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 234267013802 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 234267013803 putative metal binding site [ion binding]; other site 234267013804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267013805 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 234267013806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267013807 putative substrate translocation pore; other site 234267013808 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 234267013809 Uncharacterized conserved protein [Function unknown]; Region: COG2353 234267013810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234267013811 MarR family; Region: MarR; pfam01047 234267013812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267013813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013814 active site 234267013815 phosphorylation site [posttranslational modification] 234267013816 intermolecular recognition site; other site 234267013817 dimerization interface [polypeptide binding]; other site 234267013818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267013819 DNA binding site [nucleotide binding] 234267013820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267013821 dimerization interface [polypeptide binding]; other site 234267013822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267013823 dimer interface [polypeptide binding]; other site 234267013824 phosphorylation site [posttranslational modification] 234267013825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267013826 ATP binding site [chemical binding]; other site 234267013827 G-X-G motif; other site 234267013828 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267013829 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267013830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267013831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267013832 DNA binding site [nucleotide binding] 234267013833 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267013834 TPR repeat; Region: TPR_11; pfam13414 234267013835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267013836 TPR motif; other site 234267013837 binding surface 234267013838 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267013839 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 234267013840 structural tetrad; other site 234267013841 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267013842 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267013843 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267013844 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 234267013845 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267013846 AIR carboxylase; Region: AIRC; pfam00731 234267013847 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 234267013848 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 234267013849 NAD binding site [chemical binding]; other site 234267013850 ATP-grasp domain; Region: ATP-grasp; pfam02222 234267013851 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267013852 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267013853 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267013854 HEAT repeats; Region: HEAT_2; pfam13646 234267013855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267013856 TPR motif; other site 234267013857 binding surface 234267013858 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 234267013859 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 234267013860 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 234267013861 BNR repeat-like domain; Region: BNR_2; pfam13088 234267013862 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267013863 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267013864 active site pocket [active] 234267013865 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234267013866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267013867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267013868 catalytic residue [active] 234267013869 DinB superfamily; Region: DinB_2; pfam12867 234267013870 DinB family; Region: DinB; cl17821 234267013871 nucleoside transporter; Region: 2A0110; TIGR00889 234267013872 patatin-related protein; Region: TIGR03607 234267013873 Patatin-like phospholipase; Region: Patatin; pfam01734 234267013874 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 234267013875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267013876 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234267013877 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 234267013878 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 234267013879 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 234267013880 mannonate dehydratase; Region: uxuA; TIGR00695 234267013881 DinB superfamily; Region: DinB_2; pfam12867 234267013882 DinB family; Region: DinB; cl17821 234267013883 Bacitracin resistance protein BacA; Region: BacA; pfam02673 234267013884 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 234267013885 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 234267013886 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234267013887 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 234267013888 CheB methylesterase; Region: CheB_methylest; pfam01339 234267013889 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 234267013890 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 234267013891 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 234267013892 PAS domain; Region: PAS_10; pfam13596 234267013893 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267013894 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267013895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267013896 putative active site [active] 234267013897 heme pocket [chemical binding]; other site 234267013898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267013899 dimer interface [polypeptide binding]; other site 234267013900 phosphorylation site [posttranslational modification] 234267013901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267013902 ATP binding site [chemical binding]; other site 234267013903 Mg2+ binding site [ion binding]; other site 234267013904 G-X-G motif; other site 234267013905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013906 Response regulator receiver domain; Region: Response_reg; pfam00072 234267013907 active site 234267013908 phosphorylation site [posttranslational modification] 234267013909 intermolecular recognition site; other site 234267013910 dimerization interface [polypeptide binding]; other site 234267013911 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 234267013912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267013913 Coenzyme A binding pocket [chemical binding]; other site 234267013914 FeoA domain; Region: FeoA; pfam04023 234267013915 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 234267013916 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 234267013917 G1 box; other site 234267013918 GTP/Mg2+ binding site [chemical binding]; other site 234267013919 Switch I region; other site 234267013920 G2 box; other site 234267013921 G3 box; other site 234267013922 Switch II region; other site 234267013923 G4 box; other site 234267013924 G5 box; other site 234267013925 Nucleoside recognition; Region: Gate; pfam07670 234267013926 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 234267013927 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267013928 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267013929 catalytic residue [active] 234267013930 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 234267013931 nucleotide binding site [chemical binding]; other site 234267013932 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 234267013933 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 234267013934 active site 234267013935 DNA binding site [nucleotide binding] 234267013936 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 234267013937 DNA binding site [nucleotide binding] 234267013938 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 234267013939 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 234267013940 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 234267013941 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267013942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267013943 DNA binding residues [nucleotide binding] 234267013944 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 234267013945 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267013946 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267013947 active site 234267013948 ATP binding site [chemical binding]; other site 234267013949 substrate binding site [chemical binding]; other site 234267013950 activation loop (A-loop); other site 234267013951 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267013952 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 234267013953 Transglycosylase; Region: Transgly; pfam00912 234267013954 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267013955 PAS domain; Region: PAS; smart00091 234267013956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267013957 ATP binding site [chemical binding]; other site 234267013958 Mg2+ binding site [ion binding]; other site 234267013959 G-X-G motif; other site 234267013960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267013961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267013962 active site 234267013963 phosphorylation site [posttranslational modification] 234267013964 intermolecular recognition site; other site 234267013965 dimerization interface [polypeptide binding]; other site 234267013966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267013967 DNA binding residues [nucleotide binding] 234267013968 dimerization interface [polypeptide binding]; other site 234267013969 aldehyde dehydrogenase family 7 member; Region: PLN02315 234267013970 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 234267013971 tetrameric interface [polypeptide binding]; other site 234267013972 NAD binding site [chemical binding]; other site 234267013973 catalytic residues [active] 234267013974 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 234267013975 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 234267013976 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 234267013977 alphaNTD - beta interaction site [polypeptide binding]; other site 234267013978 alphaNTD homodimer interface [polypeptide binding]; other site 234267013979 alphaNTD - beta' interaction site [polypeptide binding]; other site 234267013980 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 234267013981 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 234267013982 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 234267013983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267013984 RNA binding surface [nucleotide binding]; other site 234267013985 30S ribosomal protein S11; Validated; Region: PRK05309 234267013986 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 234267013987 30S ribosomal protein S13; Region: bact_S13; TIGR03631 234267013988 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 234267013989 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 234267013990 rRNA binding site [nucleotide binding]; other site 234267013991 predicted 30S ribosome binding site; other site 234267013992 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 234267013993 active site 234267013994 adenylate kinase; Reviewed; Region: adk; PRK00279 234267013995 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 234267013996 AMP-binding site [chemical binding]; other site 234267013997 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 234267013998 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 234267013999 SecY translocase; Region: SecY; pfam00344 234267014000 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 234267014001 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 234267014002 23S rRNA binding site [nucleotide binding]; other site 234267014003 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 234267014004 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 234267014005 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 234267014006 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 234267014007 23S rRNA interface [nucleotide binding]; other site 234267014008 5S rRNA interface [nucleotide binding]; other site 234267014009 L27 interface [polypeptide binding]; other site 234267014010 L5 interface [polypeptide binding]; other site 234267014011 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 234267014012 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 234267014013 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 234267014014 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 234267014015 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 234267014016 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 234267014017 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 234267014018 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 234267014019 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 234267014020 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 234267014021 RNA binding site [nucleotide binding]; other site 234267014022 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 234267014023 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 234267014024 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 234267014025 putative translocon interaction site; other site 234267014026 23S rRNA interface [nucleotide binding]; other site 234267014027 signal recognition particle (SRP54) interaction site; other site 234267014028 L23 interface [polypeptide binding]; other site 234267014029 trigger factor interaction site; other site 234267014030 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 234267014031 23S rRNA interface [nucleotide binding]; other site 234267014032 5S rRNA interface [nucleotide binding]; other site 234267014033 putative antibiotic binding site [chemical binding]; other site 234267014034 L25 interface [polypeptide binding]; other site 234267014035 L27 interface [polypeptide binding]; other site 234267014036 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 234267014037 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 234267014038 G-X-X-G motif; other site 234267014039 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 234267014040 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 234267014041 putative translocon binding site; other site 234267014042 protein-rRNA interface [nucleotide binding]; other site 234267014043 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 234267014044 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 234267014045 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 234267014046 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 234267014047 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 234267014048 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 234267014049 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 234267014050 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 234267014051 elongation factor Tu; Reviewed; Region: PRK00049 234267014052 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 234267014053 G1 box; other site 234267014054 GEF interaction site [polypeptide binding]; other site 234267014055 GTP/Mg2+ binding site [chemical binding]; other site 234267014056 Switch I region; other site 234267014057 G2 box; other site 234267014058 G3 box; other site 234267014059 Switch II region; other site 234267014060 G4 box; other site 234267014061 G5 box; other site 234267014062 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 234267014063 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 234267014064 Antibiotic Binding Site [chemical binding]; other site 234267014065 elongation factor G; Reviewed; Region: PRK00007 234267014066 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 234267014067 G1 box; other site 234267014068 putative GEF interaction site [polypeptide binding]; other site 234267014069 GTP/Mg2+ binding site [chemical binding]; other site 234267014070 Switch I region; other site 234267014071 G2 box; other site 234267014072 G3 box; other site 234267014073 Switch II region; other site 234267014074 G4 box; other site 234267014075 G5 box; other site 234267014076 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 234267014077 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 234267014078 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 234267014079 30S ribosomal protein S7; Validated; Region: PRK05302 234267014080 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 234267014081 S17 interaction site [polypeptide binding]; other site 234267014082 S8 interaction site; other site 234267014083 16S rRNA interaction site [nucleotide binding]; other site 234267014084 streptomycin interaction site [chemical binding]; other site 234267014085 23S rRNA interaction site [nucleotide binding]; other site 234267014086 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 234267014087 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 234267014088 Response regulator receiver domain; Region: Response_reg; pfam00072 234267014089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014090 active site 234267014091 phosphorylation site [posttranslational modification] 234267014092 intermolecular recognition site; other site 234267014093 dimerization interface [polypeptide binding]; other site 234267014094 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 234267014095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267014096 motif II; other site 234267014097 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 234267014098 active site 234267014099 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 234267014100 active site 234267014101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267014102 putative acetyltransferase; Provisional; Region: PRK03624 234267014103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267014104 Coenzyme A binding pocket [chemical binding]; other site 234267014105 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267014106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267014107 active site 234267014108 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 234267014109 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 234267014110 NAD binding site [chemical binding]; other site 234267014111 FecR protein; Region: FecR; pfam04773 234267014112 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267014113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267014114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267014115 DNA binding residues [nucleotide binding] 234267014116 CHRD domain; Region: CHRD; cl06473 234267014117 Uncharacterized conserved protein [Function unknown]; Region: COG4198 234267014118 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 234267014119 Outer membrane efflux protein; Region: OEP; pfam02321 234267014120 Outer membrane efflux protein; Region: OEP; pfam02321 234267014121 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234267014122 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267014123 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267014124 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267014125 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014126 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014127 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014128 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 234267014129 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 234267014130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267014131 non-specific DNA binding site [nucleotide binding]; other site 234267014132 salt bridge; other site 234267014133 sequence-specific DNA binding site [nucleotide binding]; other site 234267014134 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 234267014135 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 234267014136 Hemerythrin; Region: Hemerythrin; cd12107 234267014137 Fe binding site [ion binding]; other site 234267014138 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234267014139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234267014140 DNA-binding site [nucleotide binding]; DNA binding site 234267014141 UTRA domain; Region: UTRA; pfam07702 234267014142 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014143 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267014144 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234267014145 phosphopeptide binding site; other site 234267014146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267014147 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 234267014148 Walker A motif; other site 234267014149 ATP binding site [chemical binding]; other site 234267014150 Walker B motif; other site 234267014151 arginine finger; other site 234267014152 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 234267014153 Transposase; Region: HTH_Tnp_1; pfam01527 234267014154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267014155 putative transposase OrfB; Reviewed; Region: PHA02517 234267014156 HTH-like domain; Region: HTH_21; pfam13276 234267014157 Integrase core domain; Region: rve; pfam00665 234267014158 Integrase core domain; Region: rve_3; pfam13683 234267014159 putative transposase OrfB; Reviewed; Region: PHA02517 234267014160 HTH-like domain; Region: HTH_21; pfam13276 234267014161 Integrase core domain; Region: rve; pfam00665 234267014162 Integrase core domain; Region: rve_3; pfam13683 234267014163 Transposase; Region: HTH_Tnp_1; pfam01527 234267014164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267014165 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 234267014166 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 234267014167 putative NAD(P) binding site [chemical binding]; other site 234267014168 putative substrate binding site [chemical binding]; other site 234267014169 catalytic Zn binding site [ion binding]; other site 234267014170 structural Zn binding site [ion binding]; other site 234267014171 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 234267014172 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 234267014173 substrate-cofactor binding pocket; other site 234267014174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267014175 catalytic residue [active] 234267014176 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234267014177 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 234267014178 IHF - DNA interface [nucleotide binding]; other site 234267014179 IHF dimer interface [polypeptide binding]; other site 234267014180 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 234267014181 Peptidase family M50; Region: Peptidase_M50; pfam02163 234267014182 active site 234267014183 putative substrate binding region [chemical binding]; other site 234267014184 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 234267014185 putative metal binding site; other site 234267014186 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 234267014187 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 234267014188 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267014189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267014190 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 234267014191 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 234267014192 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 234267014193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267014194 histidine kinase; Provisional; Region: PRK13557 234267014195 putative active site [active] 234267014196 heme pocket [chemical binding]; other site 234267014197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267014198 dimer interface [polypeptide binding]; other site 234267014199 phosphorylation site [posttranslational modification] 234267014200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267014201 ATP binding site [chemical binding]; other site 234267014202 Mg2+ binding site [ion binding]; other site 234267014203 G-X-G motif; other site 234267014204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014205 active site 234267014206 phosphorylation site [posttranslational modification] 234267014207 intermolecular recognition site; other site 234267014208 dimerization interface [polypeptide binding]; other site 234267014209 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234267014210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234267014211 CHASE3 domain; Region: CHASE3; pfam05227 234267014212 PAS fold; Region: PAS_4; pfam08448 234267014213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267014214 putative active site [active] 234267014215 heme pocket [chemical binding]; other site 234267014216 PAS domain S-box; Region: sensory_box; TIGR00229 234267014217 PAS domain; Region: PAS; smart00091 234267014218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267014219 putative active site [active] 234267014220 heme pocket [chemical binding]; other site 234267014221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267014222 dimer interface [polypeptide binding]; other site 234267014223 phosphorylation site [posttranslational modification] 234267014224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267014225 ATP binding site [chemical binding]; other site 234267014226 Mg2+ binding site [ion binding]; other site 234267014227 G-X-G motif; other site 234267014228 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267014229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014230 active site 234267014231 phosphorylation site [posttranslational modification] 234267014232 intermolecular recognition site; other site 234267014233 dimerization interface [polypeptide binding]; other site 234267014234 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 234267014235 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 234267014236 Fasciclin domain; Region: Fasciclin; pfam02469 234267014237 ribosome maturation protein RimP; Reviewed; Region: PRK00092 234267014238 Sm and related proteins; Region: Sm_like; cl00259 234267014239 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 234267014240 putative oligomer interface [polypeptide binding]; other site 234267014241 putative RNA binding site [nucleotide binding]; other site 234267014242 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 234267014243 NusA N-terminal domain; Region: NusA_N; pfam08529 234267014244 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 234267014245 RNA binding site [nucleotide binding]; other site 234267014246 homodimer interface [polypeptide binding]; other site 234267014247 NusA-like KH domain; Region: KH_5; pfam13184 234267014248 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 234267014249 G-X-X-G motif; other site 234267014250 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 234267014251 translation initiation factor IF-2; Region: IF-2; TIGR00487 234267014252 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 234267014253 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 234267014254 G1 box; other site 234267014255 putative GEF interaction site [polypeptide binding]; other site 234267014256 GTP/Mg2+ binding site [chemical binding]; other site 234267014257 Switch I region; other site 234267014258 G2 box; other site 234267014259 G3 box; other site 234267014260 Switch II region; other site 234267014261 G4 box; other site 234267014262 G5 box; other site 234267014263 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 234267014264 Translation-initiation factor 2; Region: IF-2; pfam11987 234267014265 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 234267014266 Protein of unknown function (DUF503); Region: DUF503; pfam04456 234267014267 Ribosome-binding factor A; Region: RBFA; pfam02033 234267014268 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267014269 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267014270 metal ion-dependent adhesion site (MIDAS); other site 234267014271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267014272 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234267014273 Walker A/P-loop; other site 234267014274 ATP binding site [chemical binding]; other site 234267014275 ABC transporter signature motif; other site 234267014276 Walker B; other site 234267014277 D-loop; other site 234267014278 H-loop/switch region; other site 234267014279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267014280 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267014281 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267014282 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 234267014283 Beta-propeller repeat; Region: SBBP; pfam06739 234267014284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 234267014285 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267014286 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 234267014287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267014288 S-adenosylmethionine binding site [chemical binding]; other site 234267014289 OsmC-like protein; Region: OsmC; pfam02566 234267014290 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267014291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267014292 S-adenosylmethionine binding site [chemical binding]; other site 234267014293 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267014294 Cupin; Region: Cupin_6; pfam12852 234267014295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267014296 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234267014297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267014298 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 234267014299 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267014300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267014301 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 234267014302 ApbE family; Region: ApbE; pfam02424 234267014303 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 234267014304 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 234267014305 substrate binding site [chemical binding]; other site 234267014306 active site 234267014307 Ferrochelatase; Region: Ferrochelatase; pfam00762 234267014308 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 234267014309 C-terminal domain interface [polypeptide binding]; other site 234267014310 active site 234267014311 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 234267014312 active site 234267014313 N-terminal domain interface [polypeptide binding]; other site 234267014314 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 234267014315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267014316 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 234267014317 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 234267014318 imidazolonepropionase; Validated; Region: PRK09356 234267014319 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 234267014320 active site 234267014321 glutamate formiminotransferase; Region: FtcD; TIGR02024 234267014322 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 234267014323 Formiminotransferase domain; Region: FTCD; pfam02971 234267014324 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 234267014325 urocanate hydratase; Provisional; Region: PRK05414 234267014326 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 234267014327 active sites [active] 234267014328 tetramer interface [polypeptide binding]; other site 234267014329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267014330 putative DNA binding site [nucleotide binding]; other site 234267014331 dimerization interface [polypeptide binding]; other site 234267014332 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234267014333 putative Zn2+ binding site [ion binding]; other site 234267014334 AsnC family; Region: AsnC_trans_reg; pfam01037 234267014335 DinB family; Region: DinB; cl17821 234267014336 DinB superfamily; Region: DinB_2; pfam12867 234267014337 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267014338 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267014339 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267014340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014341 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014342 FtsX-like permease family; Region: FtsX; pfam02687 234267014343 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267014344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267014345 active site 234267014346 ATP binding site [chemical binding]; other site 234267014347 substrate binding site [chemical binding]; other site 234267014348 activation loop (A-loop); other site 234267014349 translocation protein TolB; Provisional; Region: tolB; PRK05137 234267014350 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267014351 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267014352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267014353 DNA binding residues [nucleotide binding] 234267014354 PhoD-like phosphatase; Region: PhoD; pfam09423 234267014355 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 234267014356 putative active site [active] 234267014357 putative metal binding site [ion binding]; other site 234267014358 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267014359 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267014360 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267014361 active site 234267014362 TDP-binding site; other site 234267014363 acceptor substrate-binding pocket; other site 234267014364 homodimer interface [polypeptide binding]; other site 234267014365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267014366 dimerization interface [polypeptide binding]; other site 234267014367 putative DNA binding site [nucleotide binding]; other site 234267014368 putative Zn2+ binding site [ion binding]; other site 234267014369 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 234267014370 putative hydrophobic ligand binding site [chemical binding]; other site 234267014371 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 234267014372 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 234267014373 Outer membrane efflux protein; Region: OEP; pfam02321 234267014374 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234267014375 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014376 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267014377 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 234267014378 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 234267014379 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 234267014380 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 234267014381 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 234267014382 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 234267014383 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 234267014384 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 234267014385 Nucleoside recognition; Region: Gate; pfam07670 234267014386 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 234267014387 purine nucleoside phosphorylase; Provisional; Region: PRK08202 234267014388 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 234267014389 active site 234267014390 catalytic motif [active] 234267014391 Zn binding site [ion binding]; other site 234267014392 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 234267014393 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 234267014394 active site 234267014395 putative substrate binding pocket [chemical binding]; other site 234267014396 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267014397 Winged helix-turn helix; Region: HTH_29; pfam13551 234267014398 DNA-binding interface [nucleotide binding]; DNA binding site 234267014399 Homeodomain-like domain; Region: HTH_32; pfam13565 234267014400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267014401 Integrase core domain; Region: rve; pfam00665 234267014402 Integrase core domain; Region: rve_3; pfam13683 234267014403 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 234267014404 active site 234267014405 putative substrate binding region [chemical binding]; other site 234267014406 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 234267014407 aromatic arch; other site 234267014408 DCoH dimer interaction site [polypeptide binding]; other site 234267014409 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 234267014410 DCoH tetramer interaction site [polypeptide binding]; other site 234267014411 substrate binding site [chemical binding]; other site 234267014412 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267014413 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234267014414 ribonuclease R; Region: RNase_R; TIGR02063 234267014415 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 234267014416 RNB domain; Region: RNB; pfam00773 234267014417 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 234267014418 RNA binding site [nucleotide binding]; other site 234267014419 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267014420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267014421 Walker A/P-loop; other site 234267014422 ATP binding site [chemical binding]; other site 234267014423 Q-loop/lid; other site 234267014424 ABC transporter signature motif; other site 234267014425 Walker B; other site 234267014426 D-loop; other site 234267014427 H-loop/switch region; other site 234267014428 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267014429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014430 FtsX-like permease family; Region: FtsX; pfam02687 234267014431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014432 FtsX-like permease family; Region: FtsX; pfam02687 234267014433 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 234267014434 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 234267014435 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267014436 PA14 domain; Region: PA14; pfam07691 234267014437 FecR protein; Region: FecR; pfam04773 234267014438 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 234267014439 ATP binding site [chemical binding]; other site 234267014440 active site 234267014441 substrate binding site [chemical binding]; other site 234267014442 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 234267014443 Colicin V production protein; Region: Colicin_V; pfam02674 234267014444 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267014445 phosphoglycolate phosphatase; Provisional; Region: PRK13222 234267014446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267014447 motif II; other site 234267014448 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_4; cd06254 234267014449 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 234267014450 putative active site [active] 234267014451 Zn binding site [ion binding]; other site 234267014452 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 234267014453 metal-dependent hydrolase; Provisional; Region: PRK13291 234267014454 DinB superfamily; Region: DinB_2; pfam12867 234267014455 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267014456 C-terminal peptidase (prc); Region: prc; TIGR00225 234267014457 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 234267014458 protein binding site [polypeptide binding]; other site 234267014459 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 234267014460 Catalytic dyad [active] 234267014461 Cytochrome c; Region: Cytochrom_C; pfam00034 234267014462 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267014463 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234267014464 FAD binding domain; Region: FAD_binding_4; pfam01565 234267014465 Berberine and berberine like; Region: BBE; pfam08031 234267014466 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267014467 anti sigma factor interaction site; other site 234267014468 regulatory phosphorylation site [posttranslational modification]; other site 234267014469 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234267014470 anti sigma factor interaction site; other site 234267014471 regulatory phosphorylation site [posttranslational modification]; other site 234267014472 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 234267014473 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234267014474 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267014475 Amidase; Region: Amidase; cl11426 234267014476 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 234267014477 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267014478 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267014479 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267014480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267014481 active site 234267014482 metal binding site [ion binding]; metal-binding site 234267014483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267014484 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267014485 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267014486 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234267014487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267014488 NAD(P) binding site [chemical binding]; other site 234267014489 active site 234267014490 Cupin domain; Region: Cupin_2; pfam07883 234267014491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267014492 dimerization interface [polypeptide binding]; other site 234267014493 putative DNA binding site [nucleotide binding]; other site 234267014494 putative Zn2+ binding site [ion binding]; other site 234267014495 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267014496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267014497 S-adenosylmethionine binding site [chemical binding]; other site 234267014498 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 234267014499 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 234267014500 homotetramer interface [polypeptide binding]; other site 234267014501 ligand binding site [chemical binding]; other site 234267014502 catalytic site [active] 234267014503 NAD binding site [chemical binding]; other site 234267014504 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 234267014505 S-adenosylmethionine synthetase; Validated; Region: PRK05250 234267014506 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 234267014507 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 234267014508 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234267014509 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 234267014510 putative dimer interface [polypeptide binding]; other site 234267014511 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 234267014512 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 234267014513 putative active site [active] 234267014514 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 234267014515 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 234267014516 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 234267014517 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 234267014518 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267014519 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 234267014520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267014521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267014522 homodimer interface [polypeptide binding]; other site 234267014523 catalytic residue [active] 234267014524 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267014525 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267014526 Probable Catalytic site; other site 234267014527 metal-binding site 234267014528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267014529 TPR motif; other site 234267014530 binding surface 234267014531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267014532 TPR motif; other site 234267014533 binding surface 234267014534 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 234267014535 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 234267014536 active site 234267014537 intersubunit interface [polypeptide binding]; other site 234267014538 catalytic residue [active] 234267014539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267014540 S-adenosylmethionine binding site [chemical binding]; other site 234267014541 Predicted membrane protein [Function unknown]; Region: COG4270 234267014542 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267014543 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267014544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267014545 Ubiquitin-like proteins; Region: UBQ; cl00155 234267014546 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267014547 Asp-box motif; other site 234267014548 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267014549 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 234267014550 dimer interface [polypeptide binding]; other site 234267014551 DoxX-like family; Region: DoxX_2; pfam13564 234267014552 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 234267014553 putative hydrophobic ligand binding site [chemical binding]; other site 234267014554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 234267014555 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 234267014556 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267014557 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267014558 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267014559 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267014560 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267014561 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267014562 catalytic residues [active] 234267014563 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267014564 Sulfatase; Region: Sulfatase; pfam00884 234267014565 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 234267014566 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234267014567 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 234267014568 TPP-binding site [chemical binding]; other site 234267014569 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 234267014570 Transposase IS200 like; Region: Y1_Tnp; cl00848 234267014571 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 234267014572 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 234267014573 hexamer interface [polypeptide binding]; other site 234267014574 ligand binding site [chemical binding]; other site 234267014575 putative active site [active] 234267014576 NAD(P) binding site [chemical binding]; other site 234267014577 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234267014578 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 234267014579 FAD binding site [chemical binding]; other site 234267014580 homotetramer interface [polypeptide binding]; other site 234267014581 substrate binding pocket [chemical binding]; other site 234267014582 catalytic base [active] 234267014583 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 234267014584 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 234267014585 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267014586 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267014587 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267014588 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 234267014589 Protein export membrane protein; Region: SecD_SecF; cl14618 234267014590 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 234267014591 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 234267014592 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 234267014593 NADH dehydrogenase subunit B; Validated; Region: PRK06411 234267014594 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267014595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267014596 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267014597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 234267014598 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 234267014599 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267014600 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 234267014601 putative active site pocket [active] 234267014602 putative metal binding site [ion binding]; other site 234267014603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267014604 putative substrate translocation pore; other site 234267014605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267014606 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267014607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267014608 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267014609 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 234267014610 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 234267014611 nudix motif; other site 234267014612 Glucuronate isomerase; Region: UxaC; pfam02614 234267014613 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 234267014614 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 234267014615 Predicted peptidase [General function prediction only]; Region: COG4099 234267014616 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267014617 Amidase; Region: Amidase; cl11426 234267014618 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267014619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267014620 Tetratricopeptide repeat; Region: TPR_10; pfam13374 234267014621 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 234267014622 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 234267014623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267014624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267014625 dimer interface [polypeptide binding]; other site 234267014626 phosphorylation site [posttranslational modification] 234267014627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267014628 ATP binding site [chemical binding]; other site 234267014629 Mg2+ binding site [ion binding]; other site 234267014630 G-X-G motif; other site 234267014631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014632 Response regulator receiver domain; Region: Response_reg; pfam00072 234267014633 active site 234267014634 phosphorylation site [posttranslational modification] 234267014635 intermolecular recognition site; other site 234267014636 dimerization interface [polypeptide binding]; other site 234267014637 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267014638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014639 active site 234267014640 phosphorylation site [posttranslational modification] 234267014641 intermolecular recognition site; other site 234267014642 dimerization interface [polypeptide binding]; other site 234267014643 FOG: WD40-like repeat [Function unknown]; Region: COG1520 234267014644 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267014645 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267014646 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267014647 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267014648 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267014649 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267014650 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267014651 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267014652 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267014653 Walker A/P-loop; other site 234267014654 ATP binding site [chemical binding]; other site 234267014655 Q-loop/lid; other site 234267014656 ABC transporter signature motif; other site 234267014657 Walker B; other site 234267014658 D-loop; other site 234267014659 H-loop/switch region; other site 234267014660 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267014661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267014662 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267014663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 234267014664 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 234267014665 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267014666 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267014667 Trp docking motif [polypeptide binding]; other site 234267014668 active site 234267014669 Cytochrome c; Region: Cytochrom_C; pfam00034 234267014670 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 234267014671 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014672 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267014673 Winged helix-turn helix; Region: HTH_29; pfam13551 234267014674 DNA-binding interface [nucleotide binding]; DNA binding site 234267014675 Homeodomain-like domain; Region: HTH_32; pfam13565 234267014676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267014677 Integrase core domain; Region: rve; pfam00665 234267014678 Integrase core domain; Region: rve_3; pfam13683 234267014679 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 234267014680 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 234267014681 lipoprotein signal peptidase; Provisional; Region: PRK14787 234267014682 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 234267014683 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 234267014684 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234267014685 active site 234267014686 HIGH motif; other site 234267014687 nucleotide binding site [chemical binding]; other site 234267014688 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234267014689 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 234267014690 active site 234267014691 KMSKS motif; other site 234267014692 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 234267014693 tRNA binding surface [nucleotide binding]; other site 234267014694 anticodon binding site; other site 234267014695 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234267014696 Response regulator receiver domain; Region: Response_reg; pfam00072 234267014697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014698 active site 234267014699 phosphorylation site [posttranslational modification] 234267014700 intermolecular recognition site; other site 234267014701 dimerization interface [polypeptide binding]; other site 234267014702 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267014703 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267014704 HEAT repeats; Region: HEAT_2; pfam13646 234267014705 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 234267014706 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267014707 ligand binding site [chemical binding]; other site 234267014708 putative dehydratase; Provisional; Region: PRK08211 234267014709 Dehydratase family; Region: ILVD_EDD; cl00340 234267014710 DinB superfamily; Region: DinB_2; pfam12867 234267014711 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 234267014712 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267014713 metal binding site [ion binding]; metal-binding site 234267014714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 234267014715 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267014716 Walker A/P-loop; other site 234267014717 ATP binding site [chemical binding]; other site 234267014718 Q-loop/lid; other site 234267014719 ABC transporter signature motif; other site 234267014720 Walker B; other site 234267014721 D-loop; other site 234267014722 H-loop/switch region; other site 234267014723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 234267014724 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 234267014725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234267014726 Zn2+ binding site [ion binding]; other site 234267014727 Mg2+ binding site [ion binding]; other site 234267014728 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 234267014729 Flagellar motor switch protein FliM; Region: FliM; pfam02154 234267014730 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 234267014731 Response regulator receiver domain; Region: Response_reg; pfam00072 234267014732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014733 active site 234267014734 phosphorylation site [posttranslational modification] 234267014735 intermolecular recognition site; other site 234267014736 dimerization interface [polypeptide binding]; other site 234267014737 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 234267014738 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 234267014739 putative CheA interaction surface; other site 234267014740 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 234267014741 putative binding surface; other site 234267014742 active site 234267014743 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 234267014744 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 234267014745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267014746 ATP binding site [chemical binding]; other site 234267014747 Mg2+ binding site [ion binding]; other site 234267014748 G-X-G motif; other site 234267014749 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 234267014750 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 234267014751 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 234267014752 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 234267014753 CheD chemotactic sensory transduction; Region: CheD; cl00810 234267014754 Response regulator receiver domain; Region: Response_reg; pfam00072 234267014755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014756 active site 234267014757 phosphorylation site [posttranslational modification] 234267014758 intermolecular recognition site; other site 234267014759 dimerization interface [polypeptide binding]; other site 234267014760 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 234267014761 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 234267014762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014763 active site 234267014764 phosphorylation site [posttranslational modification] 234267014765 intermolecular recognition site; other site 234267014766 dimerization interface [polypeptide binding]; other site 234267014767 CheB methylesterase; Region: CheB_methylest; pfam01339 234267014768 Cytochrome c; Region: Cytochrom_C; pfam00034 234267014769 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267014770 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 234267014771 active site 234267014772 catalytic site [active] 234267014773 aminotransferase; Validated; Region: PRK08175 234267014774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267014775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267014776 homodimer interface [polypeptide binding]; other site 234267014777 catalytic residue [active] 234267014778 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 234267014779 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 234267014780 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267014781 catalytic residues [active] 234267014782 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014783 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267014784 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267014785 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267014786 NAD(P) binding site [chemical binding]; other site 234267014787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267014788 S-adenosylmethionine binding site [chemical binding]; other site 234267014789 Sulfatase; Region: Sulfatase; cl17466 234267014790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234267014791 CHAP domain; Region: CHAP; cl17642 234267014792 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 234267014793 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 234267014794 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 234267014795 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 234267014796 dimer interface [polypeptide binding]; other site 234267014797 TPP-binding site [chemical binding]; other site 234267014798 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 234267014799 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014800 recombination factor protein RarA; Reviewed; Region: PRK13342 234267014801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267014802 Walker A motif; other site 234267014803 ATP binding site [chemical binding]; other site 234267014804 Walker B motif; other site 234267014805 arginine finger; other site 234267014806 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 234267014807 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 234267014808 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 234267014809 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234267014810 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234267014811 putative active site [active] 234267014812 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014813 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267014814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267014815 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267014816 large terminase protein; Provisional; Region: 17; PHA02533 234267014817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267014818 Coenzyme A binding pocket [chemical binding]; other site 234267014819 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 234267014820 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 234267014821 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 234267014822 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 234267014823 TrkA-C domain; Region: TrkA_C; pfam02080 234267014824 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 234267014825 Flagellar protein FliT; Region: FliT; pfam05400 234267014826 glutaminase; Reviewed; Region: PRK12356 234267014827 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 234267014828 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 234267014829 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234267014830 Di-iron ligands [ion binding]; other site 234267014831 Trehalose utilisation; Region: ThuA; pfam06283 234267014832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234267014833 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234267014834 putative acyl-acceptor binding pocket; other site 234267014835 Cytochrome c; Region: Cytochrom_C; pfam00034 234267014836 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267014837 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267014838 Trp docking motif [polypeptide binding]; other site 234267014839 active site 234267014840 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 234267014841 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 234267014842 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 234267014843 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 234267014844 active site 234267014845 nucleophile elbow; other site 234267014846 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267014847 Response regulator receiver domain; Region: Response_reg; pfam00072 234267014848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267014849 active site 234267014850 phosphorylation site [posttranslational modification] 234267014851 intermolecular recognition site; other site 234267014852 dimerization interface [polypeptide binding]; other site 234267014853 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 234267014854 Fumarase C-terminus; Region: Fumerase_C; pfam05683 234267014855 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267014856 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267014857 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 234267014858 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 234267014859 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 234267014860 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 234267014861 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 234267014862 NAD binding site [chemical binding]; other site 234267014863 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267014864 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267014865 ligand binding site [chemical binding]; other site 234267014866 flexible hinge region; other site 234267014867 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 234267014868 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 234267014869 Protein export membrane protein; Region: SecD_SecF; cl14618 234267014870 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267014871 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267014872 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267014873 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014874 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 234267014875 putative deacylase active site [active] 234267014876 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 234267014877 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 234267014878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267014879 Walker A/P-loop; other site 234267014880 ATP binding site [chemical binding]; other site 234267014881 Q-loop/lid; other site 234267014882 ABC transporter signature motif; other site 234267014883 Walker B; other site 234267014884 D-loop; other site 234267014885 H-loop/switch region; other site 234267014886 TOBE domain; Region: TOBE; cl01440 234267014887 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 234267014888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267014889 dimer interface [polypeptide binding]; other site 234267014890 conserved gate region; other site 234267014891 putative PBP binding loops; other site 234267014892 ABC-ATPase subunit interface; other site 234267014893 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 234267014894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 234267014895 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 234267014896 active site 234267014897 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 234267014898 Peptidase family M48; Region: Peptidase_M48; cl12018 234267014899 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267014900 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267014901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267014902 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 234267014903 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 234267014904 putative binding surface; other site 234267014905 active site 234267014906 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 234267014907 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267014908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267014909 catalytic residue [active] 234267014910 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 234267014911 active site 234267014912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267014913 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 234267014914 NAD(P) binding site [chemical binding]; other site 234267014915 active site 234267014916 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 234267014917 HEAT repeats; Region: HEAT_2; pfam13646 234267014918 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267014919 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 234267014920 putative active site [active] 234267014921 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 234267014922 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 234267014923 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 234267014924 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 234267014925 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 234267014926 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 234267014927 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 234267014928 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 234267014929 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 234267014930 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 234267014931 DNA binding site [nucleotide binding] 234267014932 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 234267014933 Double zinc ribbon; Region: DZR; pfam12773 234267014934 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 234267014935 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 234267014936 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 234267014937 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 234267014938 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 234267014939 RPB12 interaction site [polypeptide binding]; other site 234267014940 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 234267014941 linker region; other site 234267014942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 234267014943 RPB3 interaction site [polypeptide binding]; other site 234267014944 RPB1 interaction site [polypeptide binding]; other site 234267014945 RPB11 interaction site [polypeptide binding]; other site 234267014946 RPB10 interaction site [polypeptide binding]; other site 234267014947 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 234267014948 core dimer interface [polypeptide binding]; other site 234267014949 peripheral dimer interface [polypeptide binding]; other site 234267014950 L10 interface [polypeptide binding]; other site 234267014951 L11 interface [polypeptide binding]; other site 234267014952 putative EF-Tu interaction site [polypeptide binding]; other site 234267014953 putative EF-G interaction site [polypeptide binding]; other site 234267014954 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 234267014955 23S rRNA interface [nucleotide binding]; other site 234267014956 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 234267014957 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 234267014958 mRNA/rRNA interface [nucleotide binding]; other site 234267014959 DinB superfamily; Region: DinB_2; pfam12867 234267014960 Protein of unknown function (DUF664); Region: DUF664; pfam04978 234267014961 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267014962 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014963 FtsX-like permease family; Region: FtsX; pfam02687 234267014964 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014965 FtsX-like permease family; Region: FtsX; pfam02687 234267014966 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267014967 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267014969 FtsX-like permease family; Region: FtsX; pfam02687 234267014970 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 234267014971 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234267014972 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267014973 active site 234267014974 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267014975 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267014976 active site 234267014977 ATP binding site [chemical binding]; other site 234267014978 substrate binding site [chemical binding]; other site 234267014979 activation loop (A-loop); other site 234267014980 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267014981 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267014982 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267014983 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267014984 TPR repeat; Region: TPR_11; pfam13414 234267014985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267014986 binding surface 234267014987 TPR motif; other site 234267014988 TPR repeat; Region: TPR_11; pfam13414 234267014989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267014990 binding surface 234267014991 TPR motif; other site 234267014992 TPR repeat; Region: TPR_11; pfam13414 234267014993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267014994 binding surface 234267014995 TPR motif; other site 234267014996 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267014997 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267014998 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267014999 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 234267015000 putative hydrophobic ligand binding site [chemical binding]; other site 234267015001 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267015002 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 234267015003 DNA binding residues [nucleotide binding] 234267015004 B12 binding domain; Region: B12-binding_2; pfam02607 234267015005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267015006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267015007 ligand binding site [chemical binding]; other site 234267015008 flexible hinge region; other site 234267015009 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 234267015010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267015011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267015012 active site 234267015013 phosphorylation site [posttranslational modification] 234267015014 intermolecular recognition site; other site 234267015015 dimerization interface [polypeptide binding]; other site 234267015016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267015017 DNA binding site [nucleotide binding] 234267015018 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 234267015019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267015020 dimerization interface [polypeptide binding]; other site 234267015021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267015022 dimer interface [polypeptide binding]; other site 234267015023 phosphorylation site [posttranslational modification] 234267015024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267015025 ATP binding site [chemical binding]; other site 234267015026 Mg2+ binding site [ion binding]; other site 234267015027 G-X-G motif; other site 234267015028 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267015029 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 234267015030 Protein of unknown function (DUF497); Region: DUF497; pfam04365 234267015031 Outer membrane efflux protein; Region: OEP; pfam02321 234267015032 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267015033 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267015034 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267015035 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267015036 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267015037 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267015038 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 234267015039 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234267015040 homodimer interface [polypeptide binding]; other site 234267015041 substrate-cofactor binding pocket; other site 234267015042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267015043 catalytic residue [active] 234267015044 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267015045 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267015046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267015047 binding surface 234267015048 TPR motif; other site 234267015049 TPR repeat; Region: TPR_11; pfam13414 234267015050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267015051 binding surface 234267015052 TPR motif; other site 234267015053 Right handed beta helix region; Region: Beta_helix; pfam13229 234267015054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267015055 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267015056 classical (c) SDRs; Region: SDR_c; cd05233 234267015057 NAD(P) binding site [chemical binding]; other site 234267015058 active site 234267015059 intracellular protease, PfpI family; Region: PfpI; TIGR01382 234267015060 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 234267015061 proposed catalytic triad [active] 234267015062 conserved cys residue [active] 234267015063 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 234267015064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267015065 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267015066 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 234267015067 active site 234267015068 RNB domain; Region: RNB; pfam00773 234267015069 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 234267015070 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234267015071 RNA binding site [nucleotide binding]; other site 234267015072 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 234267015073 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 234267015074 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 234267015075 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267015076 active site 234267015077 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267015078 active site 234267015079 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267015080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267015081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267015082 DNA binding residues [nucleotide binding] 234267015083 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 234267015084 B1 nucleotide binding pocket [chemical binding]; other site 234267015085 B2 nucleotide binding pocket [chemical binding]; other site 234267015086 CAS motifs; other site 234267015087 active site 234267015088 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267015089 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267015090 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267015091 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267015092 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267015093 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015094 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267015095 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 234267015096 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 234267015097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267015098 active site 234267015099 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 234267015100 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 234267015101 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 234267015102 dihydroorotase; Validated; Region: pyrC; PRK09357 234267015103 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267015104 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 234267015105 active site 234267015106 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 234267015107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234267015108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267015109 Coenzyme A binding pocket [chemical binding]; other site 234267015110 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234267015111 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267015112 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 234267015113 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267015114 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267015115 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267015116 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267015117 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267015118 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 234267015119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267015120 S-adenosylmethionine binding site [chemical binding]; other site 234267015121 Thioredoxin; Region: Thioredoxin_4; pfam13462 234267015122 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234267015123 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234267015124 B12 binding domain; Region: B12-binding; pfam02310 234267015125 B12 binding site [chemical binding]; other site 234267015126 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267015127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267015128 FeS/SAM binding site; other site 234267015129 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 234267015130 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 234267015131 mannonate dehydratase; Region: uxuA; TIGR00695 234267015132 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 234267015133 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 234267015134 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 234267015135 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 234267015136 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 234267015137 Nitrogen regulatory protein P-II; Region: P-II; smart00938 234267015138 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 234267015139 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 234267015140 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267015141 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267015142 Trehalose utilisation; Region: ThuA; pfam06283 234267015143 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267015144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267015145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267015146 DNA binding residues [nucleotide binding] 234267015147 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 234267015148 Putative zinc-finger; Region: zf-HC2; pfam13490 234267015149 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 234267015150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267015151 S-adenosylmethionine binding site [chemical binding]; other site 234267015152 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 234267015153 dimer interface [polypeptide binding]; other site 234267015154 substrate binding site [chemical binding]; other site 234267015155 metal binding sites [ion binding]; metal-binding site 234267015156 GntP family permease; Region: GntP_permease; pfam02447 234267015157 fructuronate transporter; Provisional; Region: PRK10034; cl15264 234267015158 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 234267015159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234267015160 dimer interface [polypeptide binding]; other site 234267015161 active site 234267015162 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 234267015163 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234267015164 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234267015165 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234267015166 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234267015167 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234267015168 substrate binding site [chemical binding]; other site 234267015169 oxyanion hole (OAH) forming residues; other site 234267015170 trimer interface [polypeptide binding]; other site 234267015171 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 234267015172 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 234267015173 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 234267015174 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267015175 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267015176 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267015177 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 234267015178 amphipathic channel; other site 234267015179 Asn-Pro-Ala signature motifs; other site 234267015180 glycerol kinase; Provisional; Region: glpK; PRK00047 234267015181 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 234267015182 N- and C-terminal domain interface [polypeptide binding]; other site 234267015183 active site 234267015184 MgATP binding site [chemical binding]; other site 234267015185 catalytic site [active] 234267015186 metal binding site [ion binding]; metal-binding site 234267015187 putative homotetramer interface [polypeptide binding]; other site 234267015188 glycerol binding site [chemical binding]; other site 234267015189 homodimer interface [polypeptide binding]; other site 234267015190 IPT/TIG domain; Region: TIG; pfam01833 234267015191 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 234267015192 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 234267015193 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267015194 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 234267015195 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 234267015196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267015197 TPR motif; other site 234267015198 binding surface 234267015199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267015200 TPR motif; other site 234267015201 binding surface 234267015202 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234267015203 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 234267015204 catalytic site [active] 234267015205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 234267015206 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 234267015207 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 234267015208 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 234267015209 dimerization interface [polypeptide binding]; other site 234267015210 metal binding site [ion binding]; metal-binding site 234267015211 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 234267015212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267015213 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267015214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267015215 active site 234267015216 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267015217 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 234267015218 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 234267015219 Protein of unknown function, DUF608; Region: DUF608; pfam04685 234267015220 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267015221 Amidohydrolase; Region: Amidohydro_4; pfam13147 234267015222 active site 234267015223 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 234267015224 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 234267015225 homodimer interface [polypeptide binding]; other site 234267015226 substrate-cofactor binding pocket; other site 234267015227 catalytic residue [active] 234267015228 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 234267015229 oligomeric interface; other site 234267015230 homodimer interface [polypeptide binding]; other site 234267015231 putative active site [active] 234267015232 Peptidase family M48; Region: Peptidase_M48; cl12018 234267015233 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267015234 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015235 FtsX-like permease family; Region: FtsX; pfam02687 234267015236 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015237 FtsX-like permease family; Region: FtsX; pfam02687 234267015238 Hemerythrin-like domain; Region: Hr-like; cd12108 234267015239 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 234267015240 Histidine kinase; Region: His_kinase; pfam06580 234267015241 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234267015242 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267015243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267015244 active site 234267015245 phosphorylation site [posttranslational modification] 234267015246 intermolecular recognition site; other site 234267015247 dimerization interface [polypeptide binding]; other site 234267015248 LytTr DNA-binding domain; Region: LytTR; smart00850 234267015249 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 234267015250 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 234267015251 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 234267015252 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 234267015253 Winged helix-turn helix; Region: HTH_29; pfam13551 234267015254 Homeodomain-like domain; Region: HTH_32; pfam13565 234267015255 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 234267015256 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 234267015257 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234267015258 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 234267015259 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 234267015260 Subunit I/III interface [polypeptide binding]; other site 234267015261 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 234267015262 Subunit I/III interface [polypeptide binding]; other site 234267015263 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 234267015264 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234267015265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267015266 NAD(P) binding site [chemical binding]; other site 234267015267 active site 234267015268 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 234267015269 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234267015270 putative NAD(P) binding site [chemical binding]; other site 234267015271 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267015272 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267015273 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015274 FtsX-like permease family; Region: FtsX; pfam02687 234267015275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015276 FtsX-like permease family; Region: FtsX; pfam02687 234267015277 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 234267015278 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 234267015279 oligomer interface [polypeptide binding]; other site 234267015280 metal binding site [ion binding]; metal-binding site 234267015281 metal binding site [ion binding]; metal-binding site 234267015282 putative Cl binding site [ion binding]; other site 234267015283 aspartate ring; other site 234267015284 basic sphincter; other site 234267015285 hydrophobic gate; other site 234267015286 periplasmic entrance; other site 234267015287 Predicted ATPase [General function prediction only]; Region: COG3911 234267015288 AAA domain; Region: AAA_28; pfam13521 234267015289 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015290 Right handed beta helix region; Region: Beta_helix; pfam13229 234267015291 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267015292 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267015293 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 234267015294 active site 234267015295 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 234267015296 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 234267015297 metal-binding site [ion binding] 234267015298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 234267015299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 234267015300 metal-binding site [ion binding] 234267015301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234267015302 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234267015303 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 234267015304 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 234267015305 active site 234267015306 dimer interface [polypeptide binding]; other site 234267015307 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 234267015308 Ligand Binding Site [chemical binding]; other site 234267015309 Molecular Tunnel; other site 234267015310 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 234267015311 peptidase domain interface [polypeptide binding]; other site 234267015312 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 234267015313 active site 234267015314 catalytic triad [active] 234267015315 calcium binding site [ion binding]; other site 234267015316 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015317 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 234267015318 peptidase domain interface [polypeptide binding]; other site 234267015319 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 234267015320 active site 234267015321 catalytic triad [active] 234267015322 calcium binding site [ion binding]; other site 234267015323 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015324 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267015325 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267015326 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267015327 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 234267015328 putative chaperone; Provisional; Region: PRK11678 234267015329 nucleotide binding site [chemical binding]; other site 234267015330 putative NEF/HSP70 interaction site [polypeptide binding]; other site 234267015331 SBD interface [polypeptide binding]; other site 234267015332 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267015333 hypothetical protein; Provisional; Region: PRK06208 234267015334 intersubunit interface [polypeptide binding]; other site 234267015335 active site 234267015336 Zn2+ binding site [ion binding]; other site 234267015337 Uncharacterized conserved protein [Function unknown]; Region: COG1915 234267015338 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 234267015339 homodimer interface [polypeptide binding]; other site 234267015340 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267015341 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 234267015342 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267015343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267015344 S-adenosylmethionine binding site [chemical binding]; other site 234267015345 NHL repeat; Region: NHL; pfam01436 234267015346 NHL repeat; Region: NHL; pfam01436 234267015347 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234267015348 NHL repeat; Region: NHL; pfam01436 234267015349 NHL repeat; Region: NHL; pfam01436 234267015350 galactonate dehydratase; Provisional; Region: PRK14017 234267015351 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 234267015352 putative active site pocket [active] 234267015353 putative metal binding site [ion binding]; other site 234267015354 manganese transport protein MntH; Reviewed; Region: PRK00701 234267015355 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234267015356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234267015357 Ligand Binding Site [chemical binding]; other site 234267015358 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 234267015359 active site 234267015360 Oxygen tolerance; Region: BatD; pfam13584 234267015361 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015362 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 234267015363 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 234267015364 Glycoprotease family; Region: Peptidase_M22; pfam00814 234267015365 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 234267015366 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 234267015367 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 234267015368 active site residue [active] 234267015369 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 234267015370 active site residue [active] 234267015371 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 234267015372 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234267015373 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267015374 Beta-propeller repeat; Region: SBBP; pfam06739 234267015375 Beta-propeller repeat; Region: SBBP; pfam06739 234267015376 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015377 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 234267015378 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267015379 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267015380 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267015381 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267015382 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267015383 Walker A/P-loop; other site 234267015384 ATP binding site [chemical binding]; other site 234267015385 Q-loop/lid; other site 234267015386 ABC transporter signature motif; other site 234267015387 Walker B; other site 234267015388 D-loop; other site 234267015389 H-loop/switch region; other site 234267015390 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267015391 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267015392 Response regulator receiver domain; Region: Response_reg; pfam00072 234267015393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267015394 active site 234267015395 phosphorylation site [posttranslational modification] 234267015396 intermolecular recognition site; other site 234267015397 dimerization interface [polypeptide binding]; other site 234267015398 ApbE family; Region: ApbE; pfam02424 234267015399 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 234267015400 cystathionine gamma-synthase; Provisional; Region: PRK07811 234267015401 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234267015402 homodimer interface [polypeptide binding]; other site 234267015403 substrate-cofactor binding pocket; other site 234267015404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267015405 catalytic residue [active] 234267015406 Ferredoxin [Energy production and conversion]; Region: COG1146 234267015407 4Fe-4S binding domain; Region: Fer4; cl02805 234267015408 Domain of unknown function (DUF749); Region: DUF749; cl01636 234267015409 pyruvate carboxylase; Reviewed; Region: PRK12999 234267015410 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234267015411 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 234267015412 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234267015413 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 234267015414 active site 234267015415 catalytic residues [active] 234267015416 metal binding site [ion binding]; metal-binding site 234267015417 homodimer binding site [polypeptide binding]; other site 234267015418 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267015419 carboxyltransferase (CT) interaction site; other site 234267015420 biotinylation site [posttranslational modification]; other site 234267015421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267015422 D-galactonate transporter; Region: 2A0114; TIGR00893 234267015423 putative substrate translocation pore; other site 234267015424 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 234267015425 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 234267015426 inhibitor binding site; inhibition site 234267015427 active site 234267015428 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 234267015429 Predicted membrane protein [Function unknown]; Region: COG4881 234267015430 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 234267015431 tetrathionate reductase subunit B; Provisional; Region: PRK14993 234267015432 4Fe-4S binding domain; Region: Fer4; cl02805 234267015433 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267015434 O-methyltransferase; Region: Methyltransf_2; pfam00891 234267015435 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234267015436 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267015437 active site 234267015438 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 234267015439 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234267015440 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234267015441 putative acyl-acceptor binding pocket; other site 234267015442 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 234267015443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234267015444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234267015445 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 234267015446 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234267015447 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 234267015448 Oligomerisation domain; Region: Oligomerisation; pfam02410 234267015449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267015450 active site 234267015451 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015452 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267015453 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267015454 active site 234267015455 metal binding site [ion binding]; metal-binding site 234267015456 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267015457 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 234267015458 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 234267015459 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 234267015460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267015461 FeS/SAM binding site; other site 234267015462 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267015463 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267015464 active site 234267015465 ATP binding site [chemical binding]; other site 234267015466 substrate binding site [chemical binding]; other site 234267015467 activation loop (A-loop); other site 234267015468 PEGA domain; Region: PEGA; pfam08308 234267015469 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267015470 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 234267015471 Agrin NtA domain; Region: NtA; pfam03146 234267015472 Cupin domain; Region: Cupin_2; cl17218 234267015473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 234267015474 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267015475 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 234267015476 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 234267015477 NADH dehydrogenase subunit D; Validated; Region: PRK06075 234267015478 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 234267015479 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 234267015480 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 234267015481 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 234267015482 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 234267015483 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 234267015484 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 234267015485 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267015486 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 234267015487 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 234267015488 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267015489 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 234267015490 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234267015491 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 234267015492 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267015493 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 234267015494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234267015495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234267015496 active site 234267015497 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 234267015498 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234267015499 dimer interface [polypeptide binding]; other site 234267015500 active site 234267015501 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 234267015502 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234267015503 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234267015504 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234267015505 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234267015506 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234267015507 substrate binding site [chemical binding]; other site 234267015508 oxyanion hole (OAH) forming residues; other site 234267015509 trimer interface [polypeptide binding]; other site 234267015510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267015511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267015512 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 234267015513 Ligand binding site [chemical binding]; other site 234267015514 Electron transfer flavoprotein domain; Region: ETF; pfam01012 234267015515 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 234267015516 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 234267015517 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 234267015518 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234267015519 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 234267015520 acyl-activating enzyme (AAE) consensus motif; other site 234267015521 putative AMP binding site [chemical binding]; other site 234267015522 putative active site [active] 234267015523 putative CoA binding site [chemical binding]; other site 234267015524 isocitrate lyase; Provisional; Region: PRK15063 234267015525 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 234267015526 tetramer interface [polypeptide binding]; other site 234267015527 active site 234267015528 Mg2+/Mn2+ binding site [ion binding]; other site 234267015529 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 234267015530 malate synthase A; Region: malate_syn_A; TIGR01344 234267015531 active site 234267015532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267015533 2-isopropylmalate synthase; Validated; Region: PRK00915 234267015534 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 234267015535 active site 234267015536 catalytic residues [active] 234267015537 metal binding site [ion binding]; metal-binding site 234267015538 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 234267015539 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 234267015540 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 234267015541 putative trimer interface [polypeptide binding]; other site 234267015542 putative active site [active] 234267015543 putative substrate binding site [chemical binding]; other site 234267015544 putative CoA binding site [chemical binding]; other site 234267015545 WxcM-like, C-terminal; Region: FdtA; pfam05523 234267015546 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267015547 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 234267015548 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 234267015549 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267015550 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267015551 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 234267015552 structural tetrad; other site 234267015553 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267015554 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267015555 Trp docking motif [polypeptide binding]; other site 234267015556 active site 234267015557 PQQ-like domain; Region: PQQ_2; pfam13360 234267015558 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015559 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267015560 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 234267015561 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 234267015562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267015563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267015564 DNA binding residues [nucleotide binding] 234267015565 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234267015566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267015567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267015568 DNA binding residues [nucleotide binding] 234267015569 Putative zinc-finger; Region: zf-HC2; pfam13490 234267015570 HEAT repeats; Region: HEAT_2; pfam13646 234267015571 HEAT repeats; Region: HEAT_2; pfam13646 234267015572 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267015573 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267015574 protein binding site [polypeptide binding]; other site 234267015575 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267015576 protein binding site [polypeptide binding]; other site 234267015577 tail fiber protein; Region: PHA00430 234267015578 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267015579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267015580 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267015581 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 234267015582 tetramerization interface [polypeptide binding]; other site 234267015583 substrate binding pocket [chemical binding]; other site 234267015584 catalytic residues [active] 234267015585 inhibitor binding sites; inhibition site 234267015586 NADP(H) binding site [chemical binding]; other site 234267015587 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267015588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015589 FtsX-like permease family; Region: FtsX; pfam02687 234267015590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015591 FtsX-like permease family; Region: FtsX; pfam02687 234267015592 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267015593 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267015594 GAF domain; Region: GAF; cl17456 234267015595 GAF domain; Region: GAF_2; pfam13185 234267015596 ANTAR domain; Region: ANTAR; pfam03861 234267015597 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267015598 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267015599 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267015600 catalytic residues [active] 234267015601 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267015602 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 234267015603 Walker A/P-loop; other site 234267015604 ATP binding site [chemical binding]; other site 234267015605 Q-loop/lid; other site 234267015606 ABC transporter signature motif; other site 234267015607 Walker B; other site 234267015608 D-loop; other site 234267015609 H-loop/switch region; other site 234267015610 SEC-C motif; Region: SEC-C; pfam02810 234267015611 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 234267015612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267015613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234267015614 Putative zinc-finger; Region: zf-HC2; pfam13490 234267015615 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 234267015616 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 234267015617 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 234267015618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 234267015619 dimer interface [polypeptide binding]; other site 234267015620 putative CheW interface [polypeptide binding]; other site 234267015621 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234267015622 metal ion-dependent adhesion site (MIDAS); other site 234267015623 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234267015624 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234267015625 metal ion-dependent adhesion site (MIDAS); other site 234267015626 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 234267015627 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267015628 Protein of unknown function DUF58; Region: DUF58; pfam01882 234267015629 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267015630 metal ion-dependent adhesion site (MIDAS); other site 234267015631 MoxR-like ATPases [General function prediction only]; Region: COG0714 234267015632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267015633 Walker A motif; other site 234267015634 ATP binding site [chemical binding]; other site 234267015635 Walker B motif; other site 234267015636 arginine finger; other site 234267015637 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 234267015638 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 234267015639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267015640 catalytic residue [active] 234267015641 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267015642 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267015643 active site 234267015644 ATP binding site [chemical binding]; other site 234267015645 substrate binding site [chemical binding]; other site 234267015646 activation loop (A-loop); other site 234267015647 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267015648 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267015649 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267015650 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267015651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267015652 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267015653 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 234267015654 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015655 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267015656 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267015657 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267015658 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234267015659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267015660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267015661 active site 234267015662 ATP binding site [chemical binding]; other site 234267015663 substrate binding site [chemical binding]; other site 234267015664 activation loop (A-loop); other site 234267015665 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267015666 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 234267015667 active site 234267015668 catalytic triad [active] 234267015669 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015670 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267015671 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 234267015672 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 234267015673 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 234267015674 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 234267015675 Cysteine-rich domain; Region: CCG; pfam02754 234267015676 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 234267015677 Cysteine-rich domain; Region: CCG; pfam02754 234267015678 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 234267015679 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 234267015680 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 234267015681 Peptidase family M50; Region: Peptidase_M50; pfam02163 234267015682 active site 234267015683 putative substrate binding region [chemical binding]; other site 234267015684 Putative Ig domain; Region: He_PIG; pfam05345 234267015685 Putative Ig domain; Region: He_PIG; pfam05345 234267015686 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 234267015687 Putative Ig domain; Region: He_PIG; pfam05345 234267015688 Putative Ig domain; Region: He_PIG; pfam05345 234267015689 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 234267015690 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 234267015691 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 234267015692 BON domain; Region: BON; pfam04972 234267015693 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 234267015694 dimerization interface [polypeptide binding]; other site 234267015695 metal binding site [ion binding]; metal-binding site 234267015696 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 234267015697 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267015698 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267015699 active site 234267015700 ATP binding site [chemical binding]; other site 234267015701 substrate binding site [chemical binding]; other site 234267015702 activation loop (A-loop); other site 234267015703 Predicted ATPase [General function prediction only]; Region: COG3899 234267015704 AAA ATPase domain; Region: AAA_16; pfam13191 234267015705 Walker A motif; other site 234267015706 ATP binding site [chemical binding]; other site 234267015707 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267015708 B12 binding site [chemical binding]; other site 234267015709 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267015710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267015711 FeS/SAM binding site; other site 234267015712 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015713 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267015714 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267015715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267015716 FeS/SAM binding site; other site 234267015717 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267015718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267015719 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267015720 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 234267015721 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267015722 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267015723 protein binding site [polypeptide binding]; other site 234267015724 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267015725 protein binding site [polypeptide binding]; other site 234267015726 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 234267015727 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 234267015728 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 234267015729 active site 234267015730 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 234267015731 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 234267015732 putative active site [active] 234267015733 putative metal binding site [ion binding]; other site 234267015734 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234267015735 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 234267015736 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 234267015737 active site 234267015738 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 234267015739 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 234267015740 arginine deiminase; Provisional; Region: PRK01388 234267015741 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 234267015742 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 234267015743 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015744 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267015745 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267015746 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267015747 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267015748 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 234267015749 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 234267015750 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 234267015751 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 234267015752 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 234267015753 active site clefts [active] 234267015754 zinc binding site [ion binding]; other site 234267015755 dimer interface [polypeptide binding]; other site 234267015756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267015757 classical (c) SDRs; Region: SDR_c; cd05233 234267015758 NAD(P) binding site [chemical binding]; other site 234267015759 active site 234267015760 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 234267015761 putative active site [active] 234267015762 catalytic residue [active] 234267015763 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 234267015764 Sel1-like repeats; Region: SEL1; smart00671 234267015765 Sel1-like repeats; Region: SEL1; smart00671 234267015766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 234267015767 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 234267015768 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 234267015769 HEAT repeats; Region: HEAT_2; pfam13646 234267015770 HEAT repeats; Region: HEAT_2; pfam13646 234267015771 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 234267015772 active site clefts [active] 234267015773 zinc binding site [ion binding]; other site 234267015774 dimer interface [polypeptide binding]; other site 234267015775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267015776 PAS domain; Region: PAS_9; pfam13426 234267015777 putative active site [active] 234267015778 heme pocket [chemical binding]; other site 234267015779 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267015780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267015781 putative active site [active] 234267015782 heme pocket [chemical binding]; other site 234267015783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267015784 dimer interface [polypeptide binding]; other site 234267015785 phosphorylation site [posttranslational modification] 234267015786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267015787 ATP binding site [chemical binding]; other site 234267015788 Mg2+ binding site [ion binding]; other site 234267015789 G-X-G motif; other site 234267015790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267015791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267015792 active site 234267015793 phosphorylation site [posttranslational modification] 234267015794 intermolecular recognition site; other site 234267015795 dimerization interface [polypeptide binding]; other site 234267015796 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 234267015797 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 234267015798 active site 234267015799 Zn binding site [ion binding]; other site 234267015800 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 234267015801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267015802 Response regulator receiver domain; Region: Response_reg; pfam00072 234267015803 active site 234267015804 phosphorylation site [posttranslational modification] 234267015805 intermolecular recognition site; other site 234267015806 dimerization interface [polypeptide binding]; other site 234267015807 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 234267015808 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 234267015809 Predicted permeases [General function prediction only]; Region: COG0795 234267015810 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 234267015811 Predicted permeases [General function prediction only]; Region: COG0795 234267015812 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 234267015813 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267015814 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267015815 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 234267015816 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 234267015817 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 234267015818 active site 234267015819 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267015820 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267015821 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267015822 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267015823 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267015824 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267015825 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267015826 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 234267015827 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267015828 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 234267015829 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 234267015830 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 234267015831 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 234267015832 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 234267015833 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267015834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267015835 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267015836 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 234267015837 PAS domain S-box; Region: sensory_box; TIGR00229 234267015838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267015839 putative active site [active] 234267015840 heme pocket [chemical binding]; other site 234267015841 PAS domain; Region: PAS_9; pfam13426 234267015842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267015843 putative active site [active] 234267015844 heme pocket [chemical binding]; other site 234267015845 PAS fold; Region: PAS_4; pfam08448 234267015846 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267015847 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267015848 active site 234267015849 catalytic tetrad [active] 234267015850 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234267015851 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 234267015852 putative NAD(P) binding site [chemical binding]; other site 234267015853 putative substrate binding site [chemical binding]; other site 234267015854 catalytic Zn binding site [ion binding]; other site 234267015855 structural Zn binding site [ion binding]; other site 234267015856 dimer interface [polypeptide binding]; other site 234267015857 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 234267015858 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 234267015859 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 234267015860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267015861 ATP binding site [chemical binding]; other site 234267015862 putative Mg++ binding site [ion binding]; other site 234267015863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267015864 nucleotide binding region [chemical binding]; other site 234267015865 ATP-binding site [chemical binding]; other site 234267015866 DEAD/H associated; Region: DEAD_assoc; pfam08494 234267015867 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 234267015868 putative deacylase active site [active] 234267015869 H+ Antiporter protein; Region: 2A0121; TIGR00900 234267015870 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 234267015871 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 234267015872 active site 234267015873 HIGH motif; other site 234267015874 dimer interface [polypeptide binding]; other site 234267015875 KMSKS motif; other site 234267015876 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 234267015877 TRAM domain; Region: TRAM; cl01282 234267015878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267015879 S-adenosylmethionine binding site [chemical binding]; other site 234267015880 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 234267015881 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 234267015882 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 234267015883 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 234267015884 HIGH motif; other site 234267015885 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234267015886 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234267015887 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234267015888 active site 234267015889 KMSKS motif; other site 234267015890 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 234267015891 tRNA binding surface [nucleotide binding]; other site 234267015892 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 234267015893 active site 234267015894 Zn binding site [ion binding]; other site 234267015895 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267015896 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267015897 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267015898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015899 FtsX-like permease family; Region: FtsX; pfam02687 234267015900 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267015901 FtsX-like permease family; Region: FtsX; pfam02687 234267015902 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 234267015903 metal-binding site 234267015904 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 234267015905 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 234267015906 XdhC Rossmann domain; Region: XdhC_C; pfam13478 234267015907 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 234267015908 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 234267015909 YcfA-like protein; Region: YcfA; pfam07927 234267015910 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234267015911 Predicted dehydrogenase [General function prediction only]; Region: COG0579 234267015912 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267015913 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267015914 active site 234267015915 ATP binding site [chemical binding]; other site 234267015916 substrate binding site [chemical binding]; other site 234267015917 activation loop (A-loop); other site 234267015918 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267015919 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 234267015920 putative [4Fe-4S] binding site [ion binding]; other site 234267015921 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 234267015922 putative molybdopterin cofactor binding site [chemical binding]; other site 234267015923 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 234267015924 molybdopterin cofactor binding site; other site 234267015925 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267015926 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267015927 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 234267015928 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 234267015929 active site 234267015930 (T/H)XGH motif; other site 234267015931 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015932 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 234267015933 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015934 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267015935 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 234267015936 dihydroxy-acid dehydratase; Validated; Region: PRK06131 234267015937 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015938 Putative Ig domain; Region: He_PIG; pfam05345 234267015939 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267015940 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015941 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267015942 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267015943 beta-D-glucuronidase; Provisional; Region: PRK10150 234267015944 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267015945 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267015946 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267015947 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 234267015948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267015949 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267015950 active site 234267015951 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267015952 catalytic tetrad [active] 234267015953 hypothetical protein; Provisional; Region: PRK06489 234267015954 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234267015955 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234267015956 active site 234267015957 TIR domain; Region: TIR_2; pfam13676 234267015958 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267015959 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267015960 Predicted transcriptional regulator [Transcription]; Region: COG1959 234267015961 Transcriptional regulator; Region: Rrf2; pfam02082 234267015962 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 234267015963 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 234267015964 dimer interface [polypeptide binding]; other site 234267015965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267015966 catalytic residue [active] 234267015967 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267015968 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 234267015969 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 234267015970 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 234267015971 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 234267015972 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 234267015973 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234267015974 ligand binding site [chemical binding]; other site 234267015975 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 234267015976 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 234267015977 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 234267015978 active site 234267015979 HIGH motif; other site 234267015980 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234267015981 tRNA binding surface [nucleotide binding]; other site 234267015982 anticodon binding site; other site 234267015983 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 234267015984 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267015985 B12 binding site [chemical binding]; other site 234267015986 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267015987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267015988 FeS/SAM binding site; other site 234267015989 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 234267015990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267015991 dimer interface [polypeptide binding]; other site 234267015992 phosphorylation site [posttranslational modification] 234267015993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267015994 ATP binding site [chemical binding]; other site 234267015995 Mg2+ binding site [ion binding]; other site 234267015996 G-X-G motif; other site 234267015997 Response regulator receiver domain; Region: Response_reg; pfam00072 234267015998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267015999 active site 234267016000 phosphorylation site [posttranslational modification] 234267016001 intermolecular recognition site; other site 234267016002 dimerization interface [polypeptide binding]; other site 234267016003 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 234267016004 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 234267016005 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234267016006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267016007 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267016008 active site 234267016009 ATP binding site [chemical binding]; other site 234267016010 substrate binding site [chemical binding]; other site 234267016011 activation loop (A-loop); other site 234267016012 PEGA domain; Region: PEGA; pfam08308 234267016013 PEGA domain; Region: PEGA; pfam08308 234267016014 BNR repeat-like domain; Region: BNR_2; pfam13088 234267016015 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234267016016 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 234267016017 dimer interface [polypeptide binding]; other site 234267016018 decamer (pentamer of dimers) interface [polypeptide binding]; other site 234267016019 catalytic triad [active] 234267016020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 234267016021 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267016022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267016023 putative active site [active] 234267016024 heme pocket [chemical binding]; other site 234267016025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267016026 dimer interface [polypeptide binding]; other site 234267016027 phosphorylation site [posttranslational modification] 234267016028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267016029 ATP binding site [chemical binding]; other site 234267016030 Mg2+ binding site [ion binding]; other site 234267016031 G-X-G motif; other site 234267016032 Response regulator receiver domain; Region: Response_reg; pfam00072 234267016033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016034 active site 234267016035 phosphorylation site [posttranslational modification] 234267016036 intermolecular recognition site; other site 234267016037 dimerization interface [polypeptide binding]; other site 234267016038 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267016039 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267016040 Metal-binding active site; metal-binding site 234267016041 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267016042 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 234267016043 NAD binding site [chemical binding]; other site 234267016044 substrate binding site [chemical binding]; other site 234267016045 homodimer interface [polypeptide binding]; other site 234267016046 active site 234267016047 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267016048 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267016049 active site 234267016050 catalytic tetrad [active] 234267016051 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267016052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267016053 putative active site [active] 234267016054 heme pocket [chemical binding]; other site 234267016055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267016056 dimer interface [polypeptide binding]; other site 234267016057 phosphorylation site [posttranslational modification] 234267016058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267016059 ATP binding site [chemical binding]; other site 234267016060 Mg2+ binding site [ion binding]; other site 234267016061 G-X-G motif; other site 234267016062 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267016063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016064 active site 234267016065 phosphorylation site [posttranslational modification] 234267016066 intermolecular recognition site; other site 234267016067 dimerization interface [polypeptide binding]; other site 234267016068 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 234267016069 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 234267016070 active site 234267016071 dimerization interface [polypeptide binding]; other site 234267016072 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267016073 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267016074 metal ion-dependent adhesion site (MIDAS); other site 234267016075 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 234267016076 MoaE interaction surface [polypeptide binding]; other site 234267016077 MoeB interaction surface [polypeptide binding]; other site 234267016078 thiocarboxylated glycine; other site 234267016079 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 234267016080 MoaE homodimer interface [polypeptide binding]; other site 234267016081 MoaD interaction [polypeptide binding]; other site 234267016082 active site residues [active] 234267016083 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 234267016084 active site 234267016085 Hemerythrin; Region: Hemerythrin; cd12107 234267016086 Fe binding site [ion binding]; other site 234267016087 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 234267016088 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234267016089 P loop; other site 234267016090 Nucleotide binding site [chemical binding]; other site 234267016091 DTAP/Switch II; other site 234267016092 Switch I; other site 234267016093 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267016094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267016095 TPR motif; other site 234267016096 binding surface 234267016097 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 234267016098 catalytic motif [active] 234267016099 Catalytic residue [active] 234267016100 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 234267016101 inhibitor binding site; inhibition site 234267016102 catalytic motif [active] 234267016103 Catalytic residue [active] 234267016104 Active site flap [active] 234267016105 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267016106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016107 active site 234267016108 phosphorylation site [posttranslational modification] 234267016109 intermolecular recognition site; other site 234267016110 dimerization interface [polypeptide binding]; other site 234267016111 Response regulator receiver domain; Region: Response_reg; pfam00072 234267016112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016113 active site 234267016114 phosphorylation site [posttranslational modification] 234267016115 intermolecular recognition site; other site 234267016116 dimerization interface [polypeptide binding]; other site 234267016117 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016118 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016119 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 234267016120 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 234267016121 ligand binding site [chemical binding]; other site 234267016122 NAD binding site [chemical binding]; other site 234267016123 tetramer interface [polypeptide binding]; other site 234267016124 catalytic site [active] 234267016125 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 234267016126 L-serine binding site [chemical binding]; other site 234267016127 ACT domain interface; other site 234267016128 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267016129 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267016130 active site 234267016131 catalytic tetrad [active] 234267016132 NHL repeat; Region: NHL; pfam01436 234267016133 NHL repeat; Region: NHL; pfam01436 234267016134 NHL repeat; Region: NHL; pfam01436 234267016135 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016136 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 234267016137 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 234267016138 tetramer interface [polypeptide binding]; other site 234267016139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267016140 catalytic residue [active] 234267016141 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 234267016142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267016143 FeS/SAM binding site; other site 234267016144 HemN C-terminal domain; Region: HemN_C; pfam06969 234267016145 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267016146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016147 TPR repeat; Region: TPR_11; pfam13414 234267016148 binding surface 234267016149 TPR motif; other site 234267016150 TPR repeat; Region: TPR_11; pfam13414 234267016151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016152 binding surface 234267016153 TPR motif; other site 234267016154 TPR repeat; Region: TPR_11; pfam13414 234267016155 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_4; cd06254 234267016156 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 234267016157 putative active site [active] 234267016158 Zn binding site [ion binding]; other site 234267016159 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 234267016160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267016161 FeS/SAM binding site; other site 234267016162 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267016163 classical (c) SDRs; Region: SDR_c; cd05233 234267016164 NAD(P) binding site [chemical binding]; other site 234267016165 active site 234267016166 hypothetical protein; Provisional; Region: PRK10621 234267016167 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234267016168 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267016169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016170 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016171 FtsX-like permease family; Region: FtsX; pfam02687 234267016172 rhamnose-proton symporter; Provisional; Region: PRK13499 234267016173 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234267016174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 234267016175 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 234267016176 ligand binding site [chemical binding]; other site 234267016177 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267016178 Domain of unknown function (DUF336); Region: DUF336; pfam03928 234267016179 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267016180 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267016181 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267016182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267016183 active site 234267016184 ATP binding site [chemical binding]; other site 234267016185 substrate binding site [chemical binding]; other site 234267016186 activation loop (A-loop); other site 234267016187 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267016188 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267016189 Domain of unknown function (DUF303); Region: DUF303; pfam03629 234267016190 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267016191 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 234267016192 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 234267016193 putative active site [active] 234267016194 catalytic triad [active] 234267016195 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 234267016196 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 234267016197 dimerization interface [polypeptide binding]; other site 234267016198 ATP binding site [chemical binding]; other site 234267016199 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 234267016200 dimerization interface [polypeptide binding]; other site 234267016201 ATP binding site [chemical binding]; other site 234267016202 amidophosphoribosyltransferase; Provisional; Region: PRK09123 234267016203 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 234267016204 active site 234267016205 tetramer interface [polypeptide binding]; other site 234267016206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267016207 active site 234267016208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267016209 Coenzyme A binding pocket [chemical binding]; other site 234267016210 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 234267016211 hypothetical protein; Validated; Region: PRK00110 234267016212 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 234267016213 active site 234267016214 putative DNA-binding cleft [nucleotide binding]; other site 234267016215 dimer interface [polypeptide binding]; other site 234267016216 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016217 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267016218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267016219 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267016220 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267016221 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 234267016222 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 234267016223 Domain of unknown function (DUF718); Region: DUF718; pfam05336 234267016224 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 234267016225 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 234267016226 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 234267016227 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267016228 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016229 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016230 FtsX-like permease family; Region: FtsX; pfam02687 234267016231 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267016232 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267016233 Lamin Tail Domain; Region: LTD; pfam00932 234267016234 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 234267016235 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234267016236 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 234267016237 putative active site [active] 234267016238 catalytic triad [active] 234267016239 putative dimer interface [polypeptide binding]; other site 234267016240 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 234267016241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267016242 catalytic residue [active] 234267016243 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 234267016244 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016245 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 234267016246 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 234267016247 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 234267016248 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267016249 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267016250 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267016251 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 234267016252 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267016253 Caspase domain; Region: Peptidase_C14; pfam00656 234267016254 PEGA domain; Region: PEGA; pfam08308 234267016255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016256 binding surface 234267016257 TPR motif; other site 234267016258 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267016259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016260 binding surface 234267016261 TPR motif; other site 234267016262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016263 binding surface 234267016264 TPR motif; other site 234267016265 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 234267016266 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 234267016267 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 234267016268 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 234267016269 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 234267016270 active site 234267016271 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234267016272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267016273 ABC transporter; Region: ABC_tran_2; pfam12848 234267016274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267016275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016276 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267016277 FtsX-like permease family; Region: FtsX; pfam02687 234267016278 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016279 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267016280 FtsX-like permease family; Region: FtsX; pfam02687 234267016281 endonuclease IV; Provisional; Region: PRK01060 234267016282 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 234267016283 AP (apurinic/apyrimidinic) site pocket; other site 234267016284 DNA interaction; other site 234267016285 Metal-binding active site; metal-binding site 234267016286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267016287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267016288 Outer membrane efflux protein; Region: OEP; pfam02321 234267016289 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 234267016290 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267016291 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267016292 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267016293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267016294 Walker A/P-loop; other site 234267016295 ATP binding site [chemical binding]; other site 234267016296 Q-loop/lid; other site 234267016297 ABC transporter signature motif; other site 234267016298 Walker B; other site 234267016299 D-loop; other site 234267016300 H-loop/switch region; other site 234267016301 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267016302 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267016303 Walker A/P-loop; other site 234267016304 ATP binding site [chemical binding]; other site 234267016305 Q-loop/lid; other site 234267016306 ABC transporter signature motif; other site 234267016307 Walker B; other site 234267016308 D-loop; other site 234267016309 H-loop/switch region; other site 234267016310 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 234267016311 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267016312 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 234267016313 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267016314 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267016315 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267016316 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 234267016317 Int/Topo IB signature motif; other site 234267016318 transcriptional repressor DicA; Reviewed; Region: PRK09706 234267016319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267016320 salt bridge; other site 234267016321 non-specific DNA binding site [nucleotide binding]; other site 234267016322 sequence-specific DNA binding site [nucleotide binding]; other site 234267016323 CHC2 zinc finger; Region: zf-CHC2; cl17510 234267016324 Domain of unknown function (DUF927); Region: DUF927; pfam06048 234267016325 Terminase small subunit; Region: Terminase_2; cl01513 234267016326 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234267016327 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 234267016328 catalytic residues [active] 234267016329 catalytic nucleophile [active] 234267016330 Recombinase; Region: Recombinase; pfam07508 234267016331 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 234267016332 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 234267016333 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 234267016334 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 234267016335 Kelch domain; Region: Kelch; smart00612 234267016336 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016337 Cupin domain; Region: Cupin_2; pfam07883 234267016338 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 234267016339 RNase_H superfamily; Region: RNase_H_2; pfam13482 234267016340 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 234267016341 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267016342 TAP-like protein; Region: Abhydrolase_4; pfam08386 234267016343 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 234267016344 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267016345 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267016346 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 234267016347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267016348 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 234267016349 DNA binding residues [nucleotide binding] 234267016350 dimerization interface [polypeptide binding]; other site 234267016351 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234267016352 active site 234267016353 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267016354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267016355 S-adenosylmethionine binding site [chemical binding]; other site 234267016356 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234267016357 active site 234267016358 PEP-CTERM motif; Region: VPEP; pfam07589 234267016359 Response regulator receiver domain; Region: Response_reg; pfam00072 234267016360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016361 active site 234267016362 phosphorylation site [posttranslational modification] 234267016363 intermolecular recognition site; other site 234267016364 dimerization interface [polypeptide binding]; other site 234267016365 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 234267016366 active site 234267016367 catalytic triad [active] 234267016368 oxyanion hole [active] 234267016369 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 234267016370 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 234267016371 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 234267016372 Acid Phosphatase; Region: Acid_PPase; cl17256 234267016373 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267016374 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 234267016375 dimer interface [polypeptide binding]; other site 234267016376 substrate binding site [chemical binding]; other site 234267016377 metal binding site [ion binding]; metal-binding site 234267016378 Response regulator receiver domain; Region: Response_reg; pfam00072 234267016379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016380 active site 234267016381 phosphorylation site [posttranslational modification] 234267016382 intermolecular recognition site; other site 234267016383 dimerization interface [polypeptide binding]; other site 234267016384 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267016386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267016387 dimer interface [polypeptide binding]; other site 234267016388 phosphorylation site [posttranslational modification] 234267016389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267016390 ATP binding site [chemical binding]; other site 234267016391 Mg2+ binding site [ion binding]; other site 234267016392 G-X-G motif; other site 234267016393 Response regulator receiver domain; Region: Response_reg; pfam00072 234267016394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016395 active site 234267016396 phosphorylation site [posttranslational modification] 234267016397 intermolecular recognition site; other site 234267016398 dimerization interface [polypeptide binding]; other site 234267016399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234267016400 Integrase core domain; Region: rve; pfam00665 234267016401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234267016402 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 234267016403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267016404 Walker A motif; other site 234267016405 ATP binding site [chemical binding]; other site 234267016406 Walker B motif; other site 234267016407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267016408 Walker A motif; other site 234267016409 ATP binding site [chemical binding]; other site 234267016410 Walker B motif; other site 234267016411 arginine finger; other site 234267016412 PilZ domain; Region: PilZ; pfam07238 234267016413 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 234267016414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016415 active site 234267016416 phosphorylation site [posttranslational modification] 234267016417 intermolecular recognition site; other site 234267016418 dimerization interface [polypeptide binding]; other site 234267016419 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267016420 PQQ-like domain; Region: PQQ_2; pfam13360 234267016421 putative transposase OrfB; Reviewed; Region: PHA02517 234267016422 HTH-like domain; Region: HTH_21; pfam13276 234267016423 Integrase core domain; Region: rve; pfam00665 234267016424 Integrase core domain; Region: rve_3; pfam13683 234267016425 Transposase; Region: HTH_Tnp_1; pfam01527 234267016426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267016427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267016428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267016429 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267016430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267016431 NAD(P) binding site [chemical binding]; other site 234267016432 active site 234267016433 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267016434 classical (c) SDRs; Region: SDR_c; cd05233 234267016435 NAD(P) binding site [chemical binding]; other site 234267016436 active site 234267016437 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234267016438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267016439 NAD(P) binding site [chemical binding]; other site 234267016440 active site 234267016441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267016442 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234267016443 active site residue [active] 234267016444 Helix-turn-helix domain; Region: HTH_17; pfam12728 234267016445 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 234267016446 Family description; Region: VCBS; pfam13517 234267016447 Family description; Region: VCBS; pfam13517 234267016448 Family description; Region: VCBS; pfam13517 234267016449 Family description; Region: VCBS; pfam13517 234267016450 Family description; Region: VCBS; pfam13517 234267016451 Family description; Region: VCBS; pfam13517 234267016452 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267016453 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267016454 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267016455 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267016456 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 234267016457 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 234267016458 homotrimer interaction site [polypeptide binding]; other site 234267016459 putative active site [active] 234267016460 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 234267016461 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 234267016462 ligand binding site [chemical binding]; other site 234267016463 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016464 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016465 Family description; Region: VCBS; pfam13517 234267016466 Family description; Region: VCBS; pfam13517 234267016467 Family description; Region: VCBS; pfam13517 234267016468 Family description; Region: VCBS; pfam13517 234267016469 Family description; Region: VCBS; pfam13517 234267016470 Family description; Region: VCBS; pfam13517 234267016471 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267016472 TPR repeat; Region: TPR_11; pfam13414 234267016473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016474 binding surface 234267016475 TPR motif; other site 234267016476 TPR repeat; Region: TPR_11; pfam13414 234267016477 TPR repeat; Region: TPR_11; pfam13414 234267016478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016479 TPR motif; other site 234267016480 binding surface 234267016481 TPR repeat; Region: TPR_11; pfam13414 234267016482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016483 binding surface 234267016484 TPR motif; other site 234267016485 TPR repeat; Region: TPR_11; pfam13414 234267016486 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 234267016487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267016488 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234267016489 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234267016490 active site 234267016491 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267016492 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 234267016493 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234267016494 active site 234267016495 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234267016496 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 234267016497 catalytic triad [active] 234267016498 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 234267016499 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 234267016500 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267016501 active site 234267016502 DNA binding site [nucleotide binding] 234267016503 Int/Topo IB signature motif; other site 234267016504 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 234267016505 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 234267016506 tyramine oxidase; Provisional; Region: tynA; PRK11504 234267016507 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267016508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267016509 S-adenosylmethionine binding site [chemical binding]; other site 234267016510 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267016511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267016512 S-adenosylmethionine binding site [chemical binding]; other site 234267016513 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267016514 PA_M28_1_3: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 3. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_3; cd04822 234267016515 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267016516 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 234267016517 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267016518 metal binding site [ion binding]; metal-binding site 234267016519 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 234267016520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 234267016521 Walker A/P-loop; other site 234267016522 ATP binding site [chemical binding]; other site 234267016523 Q-loop/lid; other site 234267016524 ABC transporter signature motif; other site 234267016525 Walker B; other site 234267016526 D-loop; other site 234267016527 H-loop/switch region; other site 234267016528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 234267016529 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 234267016530 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234267016531 TM-ABC transporter signature motif; other site 234267016532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234267016533 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 234267016534 TM-ABC transporter signature motif; other site 234267016535 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 234267016536 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 234267016537 putative ligand binding site [chemical binding]; other site 234267016538 amidase; Provisional; Region: PRK09201 234267016539 Amidase; Region: Amidase; cl11426 234267016540 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 234267016541 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267016542 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 234267016543 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016544 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267016545 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016546 Putative transposase; Region: Y2_Tnp; pfam04986 234267016547 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 234267016548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 234267016549 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 234267016550 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 234267016551 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 234267016552 multiple promoter invertase; Provisional; Region: mpi; PRK13413 234267016553 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234267016554 catalytic residues [active] 234267016555 catalytic nucleophile [active] 234267016556 Presynaptic Site I dimer interface [polypeptide binding]; other site 234267016557 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234267016558 Synaptic Flat tetramer interface [polypeptide binding]; other site 234267016559 Synaptic Site I dimer interface [polypeptide binding]; other site 234267016560 DNA binding site [nucleotide binding] 234267016561 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 234267016562 Replication initiator protein A; Region: RPA; cl17860 234267016563 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267016564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016565 active site 234267016566 phosphorylation site [posttranslational modification] 234267016567 intermolecular recognition site; other site 234267016568 dimerization interface [polypeptide binding]; other site 234267016569 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267016570 GAF domain; Region: GAF; cl17456 234267016571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267016572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267016573 ATP binding site [chemical binding]; other site 234267016574 Mg2+ binding site [ion binding]; other site 234267016575 G-X-G motif; other site 234267016576 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267016577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267016578 S-adenosylmethionine binding site [chemical binding]; other site 234267016579 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 234267016580 tetramerization interface [polypeptide binding]; other site 234267016581 substrate binding pocket [chemical binding]; other site 234267016582 catalytic residues [active] 234267016583 inhibitor binding sites; inhibition site 234267016584 NADP(H) binding site [chemical binding]; other site 234267016585 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267016586 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267016587 Trp docking motif [polypeptide binding]; other site 234267016588 active site 234267016589 Cytochrome c; Region: Cytochrom_C; pfam00034 234267016590 Family description; Region: VCBS; pfam13517 234267016591 Family description; Region: VCBS; pfam13517 234267016592 Family description; Region: VCBS; pfam13517 234267016593 Family description; Region: VCBS; pfam13517 234267016594 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267016595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016596 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267016597 TPR motif; other site 234267016598 binding surface 234267016599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016600 TPR motif; other site 234267016601 binding surface 234267016602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016603 binding surface 234267016604 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267016605 TPR motif; other site 234267016606 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016607 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016608 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267016609 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 234267016610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016611 TPR motif; other site 234267016612 binding surface 234267016613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016614 binding surface 234267016615 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267016616 TPR motif; other site 234267016617 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267016618 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267016619 Methyltransferase domain; Region: Methyltransf_12; pfam08242 234267016620 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267016621 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267016622 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 234267016623 ApbE family; Region: ApbE; pfam02424 234267016624 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267016625 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234267016626 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267016627 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267016628 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267016629 Uncharacterized conserved protein [Function unknown]; Region: COG2006 234267016630 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267016631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267016632 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234267016633 homotrimer interaction site [polypeptide binding]; other site 234267016634 putative active site [active] 234267016635 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 234267016636 ApbE family; Region: ApbE; pfam02424 234267016637 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 234267016638 putative ligand binding site [chemical binding]; other site 234267016639 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016640 dihydroorotase; Provisional; Region: PRK09237 234267016641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267016642 active site 234267016643 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 234267016644 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 234267016645 active site 234267016646 dimer interface [polypeptide binding]; other site 234267016647 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016648 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016649 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267016650 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267016651 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 234267016652 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 234267016653 PA14 domain; Region: PA14; pfam07691 234267016654 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 234267016655 Interdomain contacts; other site 234267016656 Cytokine receptor motif; other site 234267016657 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 234267016658 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267016659 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 234267016660 ligand binding site [chemical binding]; other site 234267016661 flexible hinge region; other site 234267016662 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 234267016663 putative switch regulator; other site 234267016664 non-specific DNA interactions [nucleotide binding]; other site 234267016665 DNA binding site [nucleotide binding] 234267016666 sequence specific DNA binding site [nucleotide binding]; other site 234267016667 putative cAMP binding site [chemical binding]; other site 234267016668 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 234267016669 Family description; Region: VCBS; pfam13517 234267016670 Family description; Region: VCBS; pfam13517 234267016671 Family description; Region: VCBS; pfam13517 234267016672 Family description; Region: VCBS; pfam13517 234267016673 Family description; Region: VCBS; pfam13517 234267016674 Thioredoxin; Region: Thioredoxin_4; pfam13462 234267016675 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234267016676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267016677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267016678 DNA binding residues [nucleotide binding] 234267016679 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 234267016680 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP); Region: NGN_SP; cd09886 234267016681 transcriptional activator RfaH; Region: RfaH; TIGR01955 234267016682 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267016683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016684 active site 234267016685 phosphorylation site [posttranslational modification] 234267016686 intermolecular recognition site; other site 234267016687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267016688 DNA binding residues [nucleotide binding] 234267016689 dimerization interface [polypeptide binding]; other site 234267016690 Pirin-related protein [General function prediction only]; Region: COG1741 234267016691 Pirin; Region: Pirin; pfam02678 234267016692 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 234267016693 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 234267016694 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016695 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 234267016696 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 234267016697 Walker A/P-loop; other site 234267016698 ATP binding site [chemical binding]; other site 234267016699 Q-loop/lid; other site 234267016700 ABC transporter signature motif; other site 234267016701 Walker B; other site 234267016702 D-loop; other site 234267016703 H-loop/switch region; other site 234267016704 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 234267016705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234267016706 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 234267016707 TM-ABC transporter signature motif; other site 234267016708 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 234267016709 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 234267016710 putative ligand binding site [chemical binding]; other site 234267016711 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267016712 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267016713 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267016714 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234267016715 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267016716 Sulfatase; Region: Sulfatase; pfam00884 234267016717 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 234267016718 putative active site [active] 234267016719 catalytic triad [active] 234267016720 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 234267016721 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267016722 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 234267016723 catalytic residues [active] 234267016724 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267016725 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267016726 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267016727 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267016728 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267016729 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 234267016730 ligand binding site [chemical binding]; other site 234267016731 flexible hinge region; other site 234267016732 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 234267016733 putative switch regulator; other site 234267016734 non-specific DNA interactions [nucleotide binding]; other site 234267016735 DNA binding site [nucleotide binding] 234267016736 sequence specific DNA binding site [nucleotide binding]; other site 234267016737 putative cAMP binding site [chemical binding]; other site 234267016738 Response regulator receiver domain; Region: Response_reg; pfam00072 234267016739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016740 active site 234267016741 phosphorylation site [posttranslational modification] 234267016742 intermolecular recognition site; other site 234267016743 dimerization interface [polypeptide binding]; other site 234267016744 UGMP family protein; Validated; Region: PRK09604 234267016745 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 234267016746 Domain of unknown function (DUF1736); Region: DUF1736; pfam08409 234267016747 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267016748 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267016749 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267016750 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016751 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016752 FtsX-like permease family; Region: FtsX; pfam02687 234267016753 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016754 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016755 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 234267016756 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 234267016757 tetramer interface [polypeptide binding]; other site 234267016758 active site 234267016759 Mg2+/Mn2+ binding site [ion binding]; other site 234267016760 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 234267016761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267016762 binding surface 234267016763 TPR motif; other site 234267016764 TPR repeat; Region: TPR_11; pfam13414 234267016765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 234267016766 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267016767 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 234267016768 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 234267016769 metal binding site [ion binding]; metal-binding site 234267016770 dimer interface [polypeptide binding]; other site 234267016771 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 234267016772 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 234267016773 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 234267016774 active site 234267016775 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 234267016776 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267016777 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267016778 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267016779 TonB C terminal; Region: TonB_2; pfam13103 234267016780 TolA protein; Region: tolA_full; TIGR02794 234267016781 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 234267016782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267016783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267016784 DNA binding residues [nucleotide binding] 234267016785 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 234267016786 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 234267016787 heme bH binding site [chemical binding]; other site 234267016788 Qi binding site; other site 234267016789 intrachain domain interface; other site 234267016790 heme bL binding site [chemical binding]; other site 234267016791 interchain domain interface [polypeptide binding]; other site 234267016792 Qo binding site; other site 234267016793 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 234267016794 Qo binding site; other site 234267016795 Cytochrome c; Region: Cytochrom_C; pfam00034 234267016796 Cytochrome c; Region: Cytochrom_C; pfam00034 234267016797 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 234267016798 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 234267016799 iron-sulfur cluster [ion binding]; other site 234267016800 [2Fe-2S] cluster binding site [ion binding]; other site 234267016801 methionine sulfoxide reductase A; Provisional; Region: PRK13014 234267016802 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 234267016803 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267016804 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267016805 catalytic residues [active] 234267016806 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 234267016807 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 234267016808 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 234267016809 CTP synthetase; Validated; Region: pyrG; PRK05380 234267016810 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 234267016811 Catalytic site [active] 234267016812 active site 234267016813 UTP binding site [chemical binding]; other site 234267016814 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 234267016815 active site 234267016816 putative oxyanion hole; other site 234267016817 catalytic triad [active] 234267016818 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 234267016819 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 234267016820 Ligand binding site; other site 234267016821 oligomer interface; other site 234267016822 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267016823 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267016824 metal ion-dependent adhesion site (MIDAS); other site 234267016825 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267016826 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267016827 metal ion-dependent adhesion site (MIDAS); other site 234267016828 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267016829 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267016830 metal ion-dependent adhesion site (MIDAS); other site 234267016831 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 234267016832 C-terminal peptidase (prc); Region: prc; TIGR00225 234267016833 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 234267016834 protein binding site [polypeptide binding]; other site 234267016835 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 234267016836 Catalytic dyad [active] 234267016837 transcription antitermination factor NusB; Region: nusB; TIGR01951 234267016838 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 234267016839 homopentamer interface [polypeptide binding]; other site 234267016840 active site 234267016841 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 234267016842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234267016843 substrate binding site [chemical binding]; other site 234267016844 oxyanion hole (OAH) forming residues; other site 234267016845 trimer interface [polypeptide binding]; other site 234267016846 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234267016847 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 234267016848 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 234267016849 substrate binding site; other site 234267016850 tetramer interface; other site 234267016851 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 234267016852 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 234267016853 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 234267016854 NAD binding site [chemical binding]; other site 234267016855 substrate binding site [chemical binding]; other site 234267016856 homodimer interface [polypeptide binding]; other site 234267016857 active site 234267016858 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234267016859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267016860 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 234267016861 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 234267016862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267016863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267016864 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234267016865 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 234267016866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267016867 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267016868 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267016869 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267016870 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234267016871 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267016872 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267016873 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 234267016874 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267016875 Domain of unknown function (DUF756); Region: DUF756; pfam05506 234267016876 Domain of unknown function (DUF756); Region: DUF756; pfam05506 234267016877 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 234267016878 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 234267016879 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 234267016880 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 234267016881 mce related protein; Region: MCE; pfam02470 234267016882 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267016883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016884 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016885 FtsX-like permease family; Region: FtsX; pfam02687 234267016886 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267016887 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267016888 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 234267016889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267016890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267016891 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234267016892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267016893 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267016894 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267016895 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267016896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267016897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267016898 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234267016899 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267016900 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267016901 Putative esterase; Region: Esterase; pfam00756 234267016902 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 234267016903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267016904 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267016905 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016906 FtsX-like permease family; Region: FtsX; pfam02687 234267016907 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016908 FtsX-like permease family; Region: FtsX; pfam02687 234267016909 PQQ-like domain; Region: PQQ_2; pfam13360 234267016910 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 234267016911 RibD C-terminal domain; Region: RibD_C; cl17279 234267016912 Beta-propeller repeat; Region: SBBP; pfam06739 234267016913 Beta-propeller repeat; Region: SBBP; pfam06739 234267016914 IPT/TIG domain; Region: TIG; pfam01833 234267016915 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016916 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016917 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267016918 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016919 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016920 NHL repeat; Region: NHL; pfam01436 234267016921 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267016922 NHL repeat; Region: NHL; pfam01436 234267016923 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267016924 Phosphate-induced protein 1 conserved region; Region: Phi_1; pfam04674 234267016925 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267016926 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267016927 active site 234267016928 ATP binding site [chemical binding]; other site 234267016929 substrate binding site [chemical binding]; other site 234267016930 activation loop (A-loop); other site 234267016931 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267016932 GYD domain; Region: GYD; pfam08734 234267016933 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267016934 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267016935 active site 234267016936 ATP binding site [chemical binding]; other site 234267016937 substrate binding site [chemical binding]; other site 234267016938 activation loop (A-loop); other site 234267016939 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267016940 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267016941 active site 234267016942 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267016943 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267016944 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267016945 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 234267016946 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267016947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016948 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267016949 FtsX-like permease family; Region: FtsX; pfam02687 234267016950 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267016951 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267016952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267016953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267016954 active site 234267016955 ATP binding site [chemical binding]; other site 234267016956 substrate binding site [chemical binding]; other site 234267016957 activation loop (A-loop); other site 234267016958 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 234267016959 ADP-ribose binding site [chemical binding]; other site 234267016960 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234267016961 AAA domain; Region: AAA_18; pfam13238 234267016962 active site 234267016963 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267016964 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 234267016965 Terminase-like family; Region: Terminase_6; pfam03237 234267016966 large terminase protein; Provisional; Region: 17; PHA02533 234267016967 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 234267016968 RHS Repeat; Region: RHS_repeat; pfam05593 234267016969 RHS Repeat; Region: RHS_repeat; pfam05593 234267016970 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 234267016971 RHS Repeat; Region: RHS_repeat; cl11982 234267016972 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 234267016973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267016974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016975 active site 234267016976 phosphorylation site [posttranslational modification] 234267016977 intermolecular recognition site; other site 234267016978 dimerization interface [polypeptide binding]; other site 234267016979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267016980 DNA binding site [nucleotide binding] 234267016981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267016982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267016983 dimerization interface [polypeptide binding]; other site 234267016984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267016985 dimer interface [polypeptide binding]; other site 234267016986 phosphorylation site [posttranslational modification] 234267016987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267016988 ATP binding site [chemical binding]; other site 234267016989 Mg2+ binding site [ion binding]; other site 234267016990 G-X-G motif; other site 234267016991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267016992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267016993 active site 234267016994 phosphorylation site [posttranslational modification] 234267016995 intermolecular recognition site; other site 234267016996 dimerization interface [polypeptide binding]; other site 234267016997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267016998 DNA binding site [nucleotide binding] 234267016999 Predicted membrane protein [Function unknown]; Region: COG1470 234267017000 HEAT repeats; Region: HEAT_2; pfam13646 234267017001 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267017002 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267017003 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267017004 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267017005 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267017006 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267017007 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234267017008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267017009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017010 binding surface 234267017011 TPR motif; other site 234267017012 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267017013 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234267017014 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 234267017015 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 234267017016 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 234267017017 catalytic residue [active] 234267017018 putative FPP diphosphate binding site; other site 234267017019 putative FPP binding hydrophobic cleft; other site 234267017020 dimer interface [polypeptide binding]; other site 234267017021 putative IPP diphosphate binding site; other site 234267017022 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267017023 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267017024 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 234267017025 NmrA-like family; Region: NmrA; pfam05368 234267017026 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 234267017027 NADP binding site [chemical binding]; other site 234267017028 active site 234267017029 regulatory binding site [polypeptide binding]; other site 234267017030 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 234267017031 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 234267017032 RNA binding site [nucleotide binding]; other site 234267017033 active site 234267017034 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267017035 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267017036 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267017037 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267017038 S-adenosylmethionine binding site [chemical binding]; other site 234267017039 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267017040 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267017041 Probable Catalytic site; other site 234267017042 metal-binding site 234267017043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267017044 non-specific DNA binding site [nucleotide binding]; other site 234267017045 salt bridge; other site 234267017046 sequence-specific DNA binding site [nucleotide binding]; other site 234267017047 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 234267017048 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 234267017049 Sulfatase; Region: Sulfatase; cl17466 234267017050 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234267017051 endonuclease III; Region: ENDO3c; smart00478 234267017052 minor groove reading motif; other site 234267017053 helix-hairpin-helix signature motif; other site 234267017054 substrate binding pocket [chemical binding]; other site 234267017055 active site 234267017056 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267017057 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267017058 metal ion-dependent adhesion site (MIDAS); other site 234267017059 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 234267017060 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 234267017061 NADP binding site [chemical binding]; other site 234267017062 active site 234267017063 putative substrate binding site [chemical binding]; other site 234267017064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267017065 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267017066 active site 234267017067 catalytic tetrad [active] 234267017068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234267017069 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234267017070 putative NAD(P) binding site [chemical binding]; other site 234267017071 HDOD domain; Region: HDOD; pfam08668 234267017072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267017073 Coenzyme A binding pocket [chemical binding]; other site 234267017074 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267017075 PA_M28_1_3: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 3. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_3; cd04822 234267017076 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 234267017077 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267017078 metal binding site [ion binding]; metal-binding site 234267017079 Uncharacterized ACR (DUF711); Region: DUF711; pfam05167 234267017080 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234267017081 HSP70 interaction site [polypeptide binding]; other site 234267017082 GrpE; Region: GrpE; pfam01025 234267017083 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 234267017084 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 234267017085 rod shape-determining protein MreB; Provisional; Region: PRK13930 234267017086 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 234267017087 nucleotide binding site [chemical binding]; other site 234267017088 putative NEF/HSP70 interaction site [polypeptide binding]; other site 234267017089 SBD interface [polypeptide binding]; other site 234267017090 elongation factor Tu; Reviewed; Region: PRK00049 234267017091 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 234267017092 G1 box; other site 234267017093 GEF interaction site [polypeptide binding]; other site 234267017094 GTP/Mg2+ binding site [chemical binding]; other site 234267017095 Switch I region; other site 234267017096 G2 box; other site 234267017097 G3 box; other site 234267017098 Switch II region; other site 234267017099 G4 box; other site 234267017100 G5 box; other site 234267017101 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 234267017102 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 234267017103 Antibiotic Binding Site [chemical binding]; other site 234267017104 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 234267017105 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 234267017106 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 234267017107 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 234267017108 putative homodimer interface [polypeptide binding]; other site 234267017109 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 234267017110 heterodimer interface [polypeptide binding]; other site 234267017111 homodimer interface [polypeptide binding]; other site 234267017112 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 234267017113 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 234267017114 23S rRNA interface [nucleotide binding]; other site 234267017115 L7/L12 interface [polypeptide binding]; other site 234267017116 putative thiostrepton binding site; other site 234267017117 L25 interface [polypeptide binding]; other site 234267017118 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 234267017119 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 234267017120 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 234267017121 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234267017122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267017123 putative substrate translocation pore; other site 234267017124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267017125 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 234267017126 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267017127 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267017128 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 234267017129 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 234267017130 GTP-binding protein LepA; Provisional; Region: PRK05433 234267017131 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 234267017132 G1 box; other site 234267017133 putative GEF interaction site [polypeptide binding]; other site 234267017134 GTP/Mg2+ binding site [chemical binding]; other site 234267017135 Switch I region; other site 234267017136 G2 box; other site 234267017137 G3 box; other site 234267017138 Switch II region; other site 234267017139 G4 box; other site 234267017140 G5 box; other site 234267017141 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 234267017142 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 234267017143 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 234267017144 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 234267017145 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 234267017146 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 234267017147 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 234267017148 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267017149 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267017150 Trp docking motif [polypeptide binding]; other site 234267017151 active site 234267017152 Cytochrome c; Region: Cytochrom_C; cl11414 234267017153 Cytochrome c; Region: Cytochrom_C; cl11414 234267017154 Predicted membrane protein [Function unknown]; Region: COG2311 234267017155 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 234267017156 Protein of unknown function (DUF418); Region: DUF418; pfam04235 234267017157 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 234267017158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017159 FeS/SAM binding site; other site 234267017160 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 234267017161 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267017162 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 234267017163 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267017164 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267017165 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267017166 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267017167 active site pocket [active] 234267017168 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 234267017169 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 234267017170 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267017171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267017172 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267017173 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267017174 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267017175 sensor protein ZraS; Provisional; Region: PRK10364 234267017176 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267017177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267017178 active site 234267017179 phosphorylation site [posttranslational modification] 234267017180 intermolecular recognition site; other site 234267017181 dimerization interface [polypeptide binding]; other site 234267017182 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 234267017183 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 234267017184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267017185 motif II; other site 234267017186 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 234267017187 Septum formation initiator; Region: DivIC; pfam04977 234267017188 Predicted membrane protein [Function unknown]; Region: COG4818 234267017189 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267017190 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 234267017191 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 234267017192 putative active site [active] 234267017193 putative NTP binding site [chemical binding]; other site 234267017194 putative nucleic acid binding site [nucleotide binding]; other site 234267017195 FecR protein; Region: FecR; pfam04773 234267017196 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267017197 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 234267017198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267017199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267017200 catalytic residue [active] 234267017201 PIN domain; Region: PIN_3; cl17397 234267017202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234267017203 dimer interface [polypeptide binding]; other site 234267017204 conserved gate region; other site 234267017205 ABC-ATPase subunit interface; other site 234267017206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267017207 Walker A/P-loop; other site 234267017208 ATP binding site [chemical binding]; other site 234267017209 Q-loop/lid; other site 234267017210 ABC transporter signature motif; other site 234267017211 Walker B; other site 234267017212 D-loop; other site 234267017213 H-loop/switch region; other site 234267017214 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 234267017215 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 234267017216 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 234267017217 thiamine phosphate binding site [chemical binding]; other site 234267017218 active site 234267017219 pyrophosphate binding site [ion binding]; other site 234267017220 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267017221 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267017222 metal ion-dependent adhesion site (MIDAS); other site 234267017223 excinuclease ABC subunit B; Provisional; Region: PRK05298 234267017224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267017225 ATP binding site [chemical binding]; other site 234267017226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267017227 nucleotide binding region [chemical binding]; other site 234267017228 ATP-binding site [chemical binding]; other site 234267017229 Ultra-violet resistance protein B; Region: UvrB; pfam12344 234267017230 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 234267017231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267017232 active site 234267017233 ATP binding site [chemical binding]; other site 234267017234 substrate binding site [chemical binding]; other site 234267017235 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 234267017236 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 234267017237 putative active site [active] 234267017238 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 234267017239 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 234267017240 putative active site [active] 234267017241 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 234267017242 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 234267017243 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 234267017244 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267017245 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 234267017246 DinB superfamily; Region: DinB_2; pfam12867 234267017247 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 234267017248 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 234267017249 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 234267017250 active site 234267017251 zinc binding site [ion binding]; other site 234267017252 Phosphotransferase enzyme family; Region: APH; pfam01636 234267017253 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267017254 active site 234267017255 ATP binding site [chemical binding]; other site 234267017256 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 234267017257 PLD-like domain; Region: PLDc_2; pfam13091 234267017258 putative active site [active] 234267017259 catalytic site [active] 234267017260 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 234267017261 PLD-like domain; Region: PLDc_2; pfam13091 234267017262 putative active site [active] 234267017263 catalytic site [active] 234267017264 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 234267017265 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 234267017266 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 234267017267 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 234267017268 dimer interface [polypeptide binding]; other site 234267017269 motif 1; other site 234267017270 active site 234267017271 motif 2; other site 234267017272 motif 3; other site 234267017273 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 234267017274 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 234267017275 putative tRNA-binding site [nucleotide binding]; other site 234267017276 B3/4 domain; Region: B3_4; pfam03483 234267017277 tRNA synthetase B5 domain; Region: B5; smart00874 234267017278 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234267017279 motif 1; other site 234267017280 dimer interface [polypeptide binding]; other site 234267017281 active site 234267017282 motif 2; other site 234267017283 motif 3; other site 234267017284 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 234267017285 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 234267017286 active site 234267017287 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 234267017288 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267017289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267017290 protein binding site [polypeptide binding]; other site 234267017291 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267017292 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 234267017293 protein binding site [polypeptide binding]; other site 234267017294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267017295 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267017296 DNA binding residues [nucleotide binding] 234267017297 dimerization interface [polypeptide binding]; other site 234267017298 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 234267017299 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 234267017300 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267017301 TPR repeat; Region: TPR_11; pfam13414 234267017302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017303 TPR motif; other site 234267017304 binding surface 234267017305 TPR repeat; Region: TPR_11; pfam13414 234267017306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017307 TPR motif; other site 234267017308 TPR repeat; Region: TPR_11; pfam13414 234267017309 binding surface 234267017310 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 234267017311 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 234267017312 active site 234267017313 Int/Topo IB signature motif; other site 234267017314 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 234267017315 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 234267017316 active site 234267017317 NTP binding site [chemical binding]; other site 234267017318 metal binding triad [ion binding]; metal-binding site 234267017319 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267017320 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 234267017321 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267017322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267017323 active site 234267017324 ATP binding site [chemical binding]; other site 234267017325 substrate binding site [chemical binding]; other site 234267017326 activation loop (A-loop); other site 234267017327 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267017328 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267017329 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267017330 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267017331 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267017332 active site 234267017333 substrate binding site [chemical binding]; other site 234267017334 Phosphotransferase enzyme family; Region: APH; pfam01636 234267017335 ATP binding site [chemical binding]; other site 234267017336 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234267017337 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 234267017338 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 234267017339 active site 234267017340 zinc binding site [ion binding]; other site 234267017341 PilZ domain; Region: PilZ; pfam07238 234267017342 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267017343 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267017344 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267017345 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267017346 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267017347 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267017348 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234267017349 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234267017350 MarR family; Region: MarR; pfam01047 234267017351 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 234267017352 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 234267017353 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 234267017354 Competence protein; Region: Competence; pfam03772 234267017355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267017356 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 234267017357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017358 FeS/SAM binding site; other site 234267017359 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 234267017360 Quinolinate synthetase A protein; Region: NadA; pfam02445 234267017361 B12 binding domain; Region: B12-binding; pfam02310 234267017362 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267017363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017364 FeS/SAM binding site; other site 234267017365 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234267017366 nucleoside/Zn binding site; other site 234267017367 dimer interface [polypeptide binding]; other site 234267017368 catalytic motif [active] 234267017369 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 234267017370 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 234267017371 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 234267017372 purine monophosphate binding site [chemical binding]; other site 234267017373 dimer interface [polypeptide binding]; other site 234267017374 putative catalytic residues [active] 234267017375 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 234267017376 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 234267017377 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 234267017378 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234267017379 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234267017380 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 234267017381 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 234267017382 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234267017383 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267017384 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 234267017385 Protein of unknown function DUF58; Region: DUF58; pfam01882 234267017386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234267017387 metal ion-dependent adhesion site (MIDAS); other site 234267017388 MoxR-like ATPases [General function prediction only]; Region: COG0714 234267017389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267017390 Walker A motif; other site 234267017391 ATP binding site [chemical binding]; other site 234267017392 Walker B motif; other site 234267017393 arginine finger; other site 234267017394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017395 binding surface 234267017396 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267017397 TPR motif; other site 234267017398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017399 TPR repeat; Region: TPR_11; pfam13414 234267017400 binding surface 234267017401 TPR motif; other site 234267017402 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 234267017403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017404 TPR motif; other site 234267017405 binding surface 234267017406 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 234267017407 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267017408 metal ion-dependent adhesion site (MIDAS); other site 234267017409 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 234267017410 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 234267017411 active site 234267017412 nucleophile elbow; other site 234267017413 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 234267017414 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 234267017415 minor groove reading motif; other site 234267017416 helix-hairpin-helix signature motif; other site 234267017417 substrate binding pocket [chemical binding]; other site 234267017418 active site 234267017419 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 234267017420 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 234267017421 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234267017422 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234267017423 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 234267017424 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 234267017425 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 234267017426 Uncharacterized conserved protein [Function unknown]; Region: COG1615 234267017427 TPR repeat; Region: TPR_11; pfam13414 234267017428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017429 binding surface 234267017430 TPR motif; other site 234267017431 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267017432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267017433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267017434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267017435 binding surface 234267017436 TPR motif; other site 234267017437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267017438 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267017439 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267017440 EamA-like transporter family; Region: EamA; cl17759 234267017441 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 234267017442 ligand binding site; other site 234267017443 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 234267017444 adenylate kinase; Reviewed; Region: adk; PRK00279 234267017445 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 234267017446 AMP-binding site [chemical binding]; other site 234267017447 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 234267017448 Outer membrane efflux protein; Region: OEP; pfam02321 234267017449 Outer membrane efflux protein; Region: OEP; pfam02321 234267017450 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267017451 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267017452 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267017453 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 234267017454 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 234267017455 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 234267017456 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234267017457 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 234267017458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267017459 S-adenosylmethionine binding site [chemical binding]; other site 234267017460 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 234267017461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267017462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267017463 active site 234267017464 phosphorylation site [posttranslational modification] 234267017465 intermolecular recognition site; other site 234267017466 dimerization interface [polypeptide binding]; other site 234267017467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267017468 DNA binding residues [nucleotide binding] 234267017469 dimerization interface [polypeptide binding]; other site 234267017470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267017471 Histidine kinase; Region: HisKA_3; pfam07730 234267017472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267017473 ATP binding site [chemical binding]; other site 234267017474 Mg2+ binding site [ion binding]; other site 234267017475 G-X-G motif; other site 234267017476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267017477 binding surface 234267017478 TPR motif; other site 234267017479 TPR repeat; Region: TPR_11; pfam13414 234267017480 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267017481 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267017482 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267017483 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267017484 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 234267017485 active site 234267017486 GMP synthase; Reviewed; Region: guaA; PRK00074 234267017487 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 234267017488 AMP/PPi binding site [chemical binding]; other site 234267017489 candidate oxyanion hole; other site 234267017490 catalytic triad [active] 234267017491 potential glutamine specificity residues [chemical binding]; other site 234267017492 NAD synthetase; Reviewed; Region: nadE; cl17435 234267017493 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 234267017494 Ligand Binding Site [chemical binding]; other site 234267017495 GMP synthase C terminal domain; Region: GMP_synt_C; pfam00958 234267017496 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 234267017497 periplasmic chaperone; Provisional; Region: PRK10780 234267017498 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 234267017499 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267017500 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267017501 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267017502 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267017503 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234267017504 Surface antigen; Region: Bac_surface_Ag; pfam01103 234267017505 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 234267017506 B12 binding site [chemical binding]; other site 234267017507 cobalt ligand [ion binding]; other site 234267017508 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 234267017509 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 234267017510 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 234267017511 active site 234267017512 substrate binding site [chemical binding]; other site 234267017513 metal binding site [ion binding]; metal-binding site 234267017514 Transposase IS200 like; Region: Y1_Tnp; cl00848 234267017515 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267017516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267017517 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267017518 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267017519 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267017520 Walker A/P-loop; other site 234267017521 ATP binding site [chemical binding]; other site 234267017522 Q-loop/lid; other site 234267017523 ABC transporter signature motif; other site 234267017524 Walker B; other site 234267017525 D-loop; other site 234267017526 H-loop/switch region; other site 234267017527 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267017528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017529 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017530 FtsX-like permease family; Region: FtsX; pfam02687 234267017531 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267017532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267017533 Walker A/P-loop; other site 234267017534 ATP binding site [chemical binding]; other site 234267017535 Q-loop/lid; other site 234267017536 ABC transporter signature motif; other site 234267017537 Walker B; other site 234267017538 D-loop; other site 234267017539 H-loop/switch region; other site 234267017540 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267017541 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267017542 Outer membrane efflux protein; Region: OEP; pfam02321 234267017543 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017544 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267017545 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 234267017546 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 234267017547 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267017548 HlyD family secretion protein; Region: HlyD_2; pfam12700 234267017549 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267017550 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 234267017551 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267017552 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267017553 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267017554 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267017555 ScpA/B protein; Region: ScpA_ScpB; cl00598 234267017556 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 234267017557 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 234267017558 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267017559 RNA binding surface [nucleotide binding]; other site 234267017560 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 234267017561 active site 234267017562 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 234267017563 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 234267017564 SnoaL-like domain; Region: SnoaL_3; pfam13474 234267017565 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267017566 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017567 FtsX-like permease family; Region: FtsX; pfam02687 234267017568 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017569 FtsX-like permease family; Region: FtsX; pfam02687 234267017570 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 234267017571 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 234267017572 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 234267017573 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 234267017574 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 234267017575 proline aminopeptidase P II; Provisional; Region: PRK10879 234267017576 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 234267017577 active site 234267017578 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267017579 M28 Zn-Peptidases; Region: M28_like_4; cd08015 234267017580 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267017581 metal binding site [ion binding]; metal-binding site 234267017582 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 234267017583 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 234267017584 active site residue [active] 234267017585 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 234267017586 active site residue [active] 234267017587 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 234267017588 triosephosphate isomerase; Provisional; Region: PRK14565 234267017589 substrate binding site [chemical binding]; other site 234267017590 dimer interface [polypeptide binding]; other site 234267017591 catalytic triad [active] 234267017592 phosphopentomutase; Provisional; Region: PRK05362 234267017593 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 234267017594 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 234267017595 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234267017596 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234267017597 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 234267017598 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 234267017599 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 234267017600 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 234267017601 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267017602 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 234267017603 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267017604 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 234267017605 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267017606 metal binding site [ion binding]; metal-binding site 234267017607 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 234267017608 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234267017609 Active Sites [active] 234267017610 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 234267017611 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 234267017612 CysD dimerization site [polypeptide binding]; other site 234267017613 G1 box; other site 234267017614 putative GEF interaction site [polypeptide binding]; other site 234267017615 GTP/Mg2+ binding site [chemical binding]; other site 234267017616 Switch I region; other site 234267017617 G2 box; other site 234267017618 G3 box; other site 234267017619 Switch II region; other site 234267017620 G4 box; other site 234267017621 G5 box; other site 234267017622 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 234267017623 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 234267017624 PEP-CTERM motif; Region: VPEP; pfam07589 234267017625 Beta-propeller repeat; Region: SBBP; pfam06739 234267017626 Beta-propeller repeat; Region: SBBP; pfam06739 234267017627 Beta-propeller repeat; Region: SBBP; pfam06739 234267017628 Beta-propeller repeat; Region: SBBP; pfam06739 234267017629 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267017630 fumarylacetoacetase; Region: PLN02856 234267017631 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 234267017632 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234267017633 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 234267017634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 234267017635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267017636 Integrase core domain; Region: rve; pfam00665 234267017637 Integrase core domain; Region: rve_3; pfam13683 234267017638 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267017639 Winged helix-turn helix; Region: HTH_29; pfam13551 234267017640 DNA-binding interface [nucleotide binding]; DNA binding site 234267017641 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267017642 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267017643 structural tetrad; other site 234267017644 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267017645 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267017646 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017647 FtsX-like permease family; Region: FtsX; pfam02687 234267017648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017649 FtsX-like permease family; Region: FtsX; pfam02687 234267017650 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 234267017651 TadE-like protein; Region: TadE; pfam07811 234267017652 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 234267017653 TadE-like protein; Region: TadE; pfam07811 234267017654 Carboxylesterase family; Region: COesterase; pfam00135 234267017655 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267017656 substrate binding pocket [chemical binding]; other site 234267017657 catalytic triad [active] 234267017658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267017659 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267017660 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267017661 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 234267017662 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267017663 active site 234267017664 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 234267017665 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 234267017666 NAD(P) binding site [chemical binding]; other site 234267017667 catalytic residues [active] 234267017668 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 234267017669 putative amphipathic alpha helix; other site 234267017670 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267017671 Sulfatase; Region: Sulfatase; cl17466 234267017672 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267017673 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267017674 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267017675 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 234267017676 Protein of unknown function (DUF497); Region: DUF497; pfam04365 234267017677 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 234267017678 YcfA-like protein; Region: YcfA; pfam07927 234267017679 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267017680 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267017681 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267017682 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267017683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267017684 active site 234267017685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267017686 active site 234267017687 HupF/HypC family; Region: HupF_HypC; pfam01455 234267017688 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 234267017689 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 234267017690 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 234267017691 dimer interface [polypeptide binding]; other site 234267017692 active site 234267017693 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 234267017694 dimerization interface [polypeptide binding]; other site 234267017695 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 234267017696 ATP binding site [chemical binding]; other site 234267017697 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 234267017698 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 234267017699 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 234267017700 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 234267017701 nickel binding site [ion binding]; other site 234267017702 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 234267017703 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267017704 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 234267017705 active site 234267017706 catalytic triad [active] 234267017707 oxyanion hole [active] 234267017708 asparagine synthetase AsnA; Provisional; Region: PRK05425 234267017709 motif 1; other site 234267017710 dimer interface [polypeptide binding]; other site 234267017711 active site 234267017712 motif 2; other site 234267017713 motif 3; other site 234267017714 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 234267017715 Peptidase family U32; Region: Peptidase_U32; pfam01136 234267017716 Collagenase; Region: DUF3656; pfam12392 234267017717 Peptidase family U32; Region: Peptidase_U32; cl03113 234267017718 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267017719 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 234267017720 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 234267017721 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 234267017722 active site 234267017723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017724 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267017725 FtsX-like permease family; Region: FtsX; pfam02687 234267017726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017727 FtsX-like permease family; Region: FtsX; pfam02687 234267017728 TIGR03118 family protein; Region: PEPCTERM_chp_1 234267017729 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267017730 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267017731 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267017732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267017733 Walker A/P-loop; other site 234267017734 ATP binding site [chemical binding]; other site 234267017735 Q-loop/lid; other site 234267017736 ABC transporter signature motif; other site 234267017737 Walker B; other site 234267017738 D-loop; other site 234267017739 H-loop/switch region; other site 234267017740 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267017741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267017742 active site 234267017743 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267017744 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267017745 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267017746 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 234267017747 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267017748 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234267017749 homotrimer interaction site [polypeptide binding]; other site 234267017750 putative active site [active] 234267017751 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 234267017752 Proline racemase; Region: Pro_racemase; pfam05544 234267017753 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 234267017754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267017755 NAD(P) binding site [chemical binding]; other site 234267017756 active site 234267017757 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 234267017758 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234267017759 active site 234267017760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267017761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267017762 putative substrate translocation pore; other site 234267017763 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 234267017764 Predicted metalloprotease [General function prediction only]; Region: COG2321 234267017765 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 234267017766 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267017767 putative active site [active] 234267017768 Zn binding site [ion binding]; other site 234267017769 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267017770 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267017771 short chain dehydrogenase; Provisional; Region: PRK06500 234267017772 classical (c) SDRs; Region: SDR_c; cd05233 234267017773 NAD(P) binding site [chemical binding]; other site 234267017774 active site 234267017775 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 234267017776 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234267017777 acyl-activating enzyme (AAE) consensus motif; other site 234267017778 AMP binding site [chemical binding]; other site 234267017779 active site 234267017780 CoA binding site [chemical binding]; other site 234267017781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267017782 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267017783 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 234267017784 Na binding site [ion binding]; other site 234267017785 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 234267017786 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 234267017787 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 234267017788 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 234267017789 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 234267017790 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267017791 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017792 FtsX-like permease family; Region: FtsX; pfam02687 234267017793 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017794 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 234267017795 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 234267017796 proposed catalytic triad [active] 234267017797 active site nucleophile [active] 234267017798 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267017799 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017800 FtsX-like permease family; Region: FtsX; pfam02687 234267017801 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267017802 FtsX-like permease family; Region: FtsX; pfam02687 234267017803 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267017804 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267017805 GAF domain; Region: GAF_3; pfam13492 234267017806 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 234267017807 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 234267017808 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267017809 structural tetrad; other site 234267017810 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267017811 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267017812 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 234267017813 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 234267017814 putative active site [active] 234267017815 catalytic site [active] 234267017816 HEAT repeats; Region: HEAT_2; pfam13646 234267017817 HEAT repeats; Region: HEAT_2; pfam13646 234267017818 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 234267017819 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267017820 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267017821 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267017822 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267017823 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234267017824 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267017825 catalytic loop [active] 234267017826 iron binding site [ion binding]; other site 234267017827 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267017828 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267017829 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267017830 active site 234267017831 ATP binding site [chemical binding]; other site 234267017832 substrate binding site [chemical binding]; other site 234267017833 activation loop (A-loop); other site 234267017834 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267017835 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267017836 active site 234267017837 ATP binding site [chemical binding]; other site 234267017838 substrate binding site [chemical binding]; other site 234267017839 activation loop (A-loop); other site 234267017840 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 234267017841 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267017842 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267017843 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 234267017844 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267017845 O-Antigen ligase; Region: Wzy_C; pfam04932 234267017846 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 234267017847 Chain length determinant protein; Region: Wzz; cl15801 234267017848 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267017849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267017850 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234267017851 Cytochrome P450; Region: p450; cl12078 234267017852 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 234267017853 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267017854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017855 FeS/SAM binding site; other site 234267017856 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267017857 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267017858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017859 FeS/SAM binding site; other site 234267017860 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267017861 B12 binding site [chemical binding]; other site 234267017862 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267017863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017864 FeS/SAM binding site; other site 234267017865 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267017866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267017867 S-adenosylmethionine binding site [chemical binding]; other site 234267017868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267017869 S-adenosylmethionine binding site [chemical binding]; other site 234267017870 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 234267017871 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 234267017872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017873 FeS/SAM binding site; other site 234267017874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267017875 S-adenosylmethionine binding site [chemical binding]; other site 234267017876 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267017877 active site 234267017878 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 234267017879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017880 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 234267017881 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 234267017882 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 234267017883 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 234267017884 putative ADP-binding pocket [chemical binding]; other site 234267017885 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267017886 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234267017887 hypothetical protein; Provisional; Region: PRK09262 234267017888 hypothetical protein; Validated; Region: PRK06201 234267017889 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 234267017890 Sensors of blue-light using FAD; Region: BLUF; smart01034 234267017891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234267017892 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 234267017893 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 234267017894 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267017895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267017896 Walker A motif; other site 234267017897 ATP binding site [chemical binding]; other site 234267017898 Walker B motif; other site 234267017899 arginine finger; other site 234267017900 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267017901 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 234267017902 Predicted membrane protein [Function unknown]; Region: COG2510 234267017903 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 234267017904 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14669 234267017905 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 234267017906 GIY-YIG motif/motif A; other site 234267017907 active site 234267017908 catalytic site [active] 234267017909 putative DNA binding site [nucleotide binding]; other site 234267017910 metal binding site [ion binding]; metal-binding site 234267017911 UvrB/uvrC motif; Region: UVR; pfam02151 234267017912 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 234267017913 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 234267017914 DNA binding site [nucleotide binding] 234267017915 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 234267017916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267017917 FeS/SAM binding site; other site 234267017918 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 234267017919 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267017920 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267017921 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267017922 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267017923 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 234267017924 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234267017925 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 234267017926 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 234267017927 active site 234267017928 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267017929 Amidase; Region: Amidase; cl11426 234267017930 Response regulator receiver domain; Region: Response_reg; pfam00072 234267017931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267017932 active site 234267017933 phosphorylation site [posttranslational modification] 234267017934 intermolecular recognition site; other site 234267017935 dimerization interface [polypeptide binding]; other site 234267017936 GAF domain; Region: GAF; cl17456 234267017937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267017938 dimer interface [polypeptide binding]; other site 234267017939 phosphorylation site [posttranslational modification] 234267017940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234267017941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267017942 ATP binding site [chemical binding]; other site 234267017943 Mg2+ binding site [ion binding]; other site 234267017944 G-X-G motif; other site 234267017945 Response regulator receiver domain; Region: Response_reg; pfam00072 234267017946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267017947 active site 234267017948 phosphorylation site [posttranslational modification] 234267017949 intermolecular recognition site; other site 234267017950 dimerization interface [polypeptide binding]; other site 234267017951 PAS domain; Region: PAS_9; pfam13426 234267017952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267017953 dimer interface [polypeptide binding]; other site 234267017954 phosphorylation site [posttranslational modification] 234267017955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267017956 ATP binding site [chemical binding]; other site 234267017957 Mg2+ binding site [ion binding]; other site 234267017958 G-X-G motif; other site 234267017959 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267017960 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 234267017961 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267017962 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267017963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267017964 active site 234267017965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234267017966 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267017967 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267017968 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267017969 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267017970 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267017971 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 234267017972 substrate binding site [chemical binding]; other site 234267017973 ATP binding site [chemical binding]; other site 234267017974 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 234267017975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267017976 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 234267017977 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267017978 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234267017979 DNA binding site [nucleotide binding] 234267017980 domain linker motif; other site 234267017981 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267017982 ligand binding site [chemical binding]; other site 234267017983 dimerization interface [polypeptide binding]; other site 234267017984 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 234267017985 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267017986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267017987 D-galactonate transporter; Region: 2A0114; TIGR00893 234267017988 putative substrate translocation pore; other site 234267017989 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 234267017990 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 234267017991 tetramer interface [polypeptide binding]; other site 234267017992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267017993 catalytic residue [active] 234267017994 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 234267017995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234267017996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267017997 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 234267017998 putative dimerization interface [polypeptide binding]; other site 234267017999 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267018000 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267018001 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267018002 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 234267018003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267018004 S-adenosylmethionine binding site [chemical binding]; other site 234267018005 peptide chain release factor 1; Validated; Region: prfA; PRK00591 234267018006 This domain is found in peptide chain release factors; Region: PCRF; smart00937 234267018007 RF-1 domain; Region: RF-1; pfam00472 234267018008 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 234267018009 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 234267018010 TIGR01777 family protein; Region: yfcH 234267018011 putative NAD(P) binding site [chemical binding]; other site 234267018012 putative active site [active] 234267018013 photolyase PhrII; Region: phr2; TIGR00591 234267018014 DNA photolyase; Region: DNA_photolyase; pfam00875 234267018015 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 234267018016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267018017 FeS/SAM binding site; other site 234267018018 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 234267018019 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267018020 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 234267018021 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 234267018022 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 234267018023 FMN binding site [chemical binding]; other site 234267018024 active site 234267018025 catalytic residues [active] 234267018026 substrate binding site [chemical binding]; other site 234267018027 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 234267018028 RNA/DNA hybrid binding site [nucleotide binding]; other site 234267018029 active site 234267018030 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 234267018031 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 234267018032 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 234267018033 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267018034 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267018035 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 234267018036 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 234267018037 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267018038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267018039 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267018040 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234267018041 catalytic core [active] 234267018042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 234267018043 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 234267018044 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 234267018045 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234267018046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 234267018047 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 234267018048 active site 234267018049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267018050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267018051 dimerization interface [polypeptide binding]; other site 234267018052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267018053 dimer interface [polypeptide binding]; other site 234267018054 phosphorylation site [posttranslational modification] 234267018055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267018056 ATP binding site [chemical binding]; other site 234267018057 Mg2+ binding site [ion binding]; other site 234267018058 G-X-G motif; other site 234267018059 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 234267018060 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018061 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 234267018062 Response regulator receiver domain; Region: Response_reg; pfam00072 234267018063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018064 active site 234267018065 phosphorylation site [posttranslational modification] 234267018066 intermolecular recognition site; other site 234267018067 dimerization interface [polypeptide binding]; other site 234267018068 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267018069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018070 active site 234267018071 phosphorylation site [posttranslational modification] 234267018072 intermolecular recognition site; other site 234267018073 dimerization interface [polypeptide binding]; other site 234267018074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267018075 DNA binding site [nucleotide binding] 234267018076 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 234267018077 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234267018078 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 234267018079 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 234267018080 iron-sulfur cluster [ion binding]; other site 234267018081 [2Fe-2S] cluster binding site [ion binding]; other site 234267018082 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810 234267018083 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 234267018084 DNA binding site [nucleotide binding] 234267018085 catalytic residue [active] 234267018086 H2TH interface [polypeptide binding]; other site 234267018087 putative catalytic residues [active] 234267018088 turnover-facilitating residue; other site 234267018089 intercalation triad [nucleotide binding]; other site 234267018090 8OG recognition residue [nucleotide binding]; other site 234267018091 putative reading head residues; other site 234267018092 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234267018093 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234267018094 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 234267018095 active site 234267018096 intersubunit interactions; other site 234267018097 catalytic residue [active] 234267018098 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 234267018099 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 234267018100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267018101 FeS/SAM binding site; other site 234267018102 TRAM domain; Region: TRAM; pfam01938 234267018103 Bifunctional nuclease; Region: DNase-RNase; pfam02577 234267018104 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 234267018105 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 234267018106 active site 234267018107 HIGH motif; other site 234267018108 dimer interface [polypeptide binding]; other site 234267018109 KMSKS motif; other site 234267018110 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267018111 RNA binding surface [nucleotide binding]; other site 234267018112 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 234267018113 dihydropteroate synthase; Region: DHPS; TIGR01496 234267018114 substrate binding pocket [chemical binding]; other site 234267018115 dimer interface [polypeptide binding]; other site 234267018116 inhibitor binding site; inhibition site 234267018117 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 234267018118 putative active site [active] 234267018119 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 234267018120 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267018121 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 234267018122 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267018123 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 234267018124 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 234267018125 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 234267018126 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 234267018127 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14660 234267018128 nickel responsive regulator; Provisional; Region: PRK04460 234267018129 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 234267018130 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 234267018131 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 234267018132 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 234267018133 Cobalt transport protein; Region: CbiQ; cl00463 234267018134 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 234267018135 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 234267018136 Walker A/P-loop; other site 234267018137 ATP binding site [chemical binding]; other site 234267018138 Q-loop/lid; other site 234267018139 ABC transporter signature motif; other site 234267018140 Walker B; other site 234267018141 D-loop; other site 234267018142 H-loop/switch region; other site 234267018143 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 234267018144 putative active site [active] 234267018145 dimerization interface [polypeptide binding]; other site 234267018146 putative tRNAtyr binding site [nucleotide binding]; other site 234267018147 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 234267018148 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 234267018149 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267018150 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267018151 active site 234267018152 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267018153 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 234267018154 active site 234267018155 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267018156 active site 234267018157 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 234267018158 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 234267018159 dimerization interface [polypeptide binding]; other site 234267018160 putative ATP binding site [chemical binding]; other site 234267018161 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 234267018162 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 234267018163 active site 234267018164 substrate binding site [chemical binding]; other site 234267018165 cosubstrate binding site; other site 234267018166 catalytic site [active] 234267018167 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267018168 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 234267018169 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 234267018170 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 234267018171 MgtE intracellular N domain; Region: MgtE_N; pfam03448 234267018172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 234267018173 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 234267018174 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234267018175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234267018176 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 234267018177 NAD(P) binding site [chemical binding]; other site 234267018178 catalytic residues [active] 234267018179 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 234267018180 putative catalytic site [active] 234267018181 putative phosphate binding site [ion binding]; other site 234267018182 active site 234267018183 metal binding site A [ion binding]; metal-binding site 234267018184 DNA binding site [nucleotide binding] 234267018185 putative AP binding site [nucleotide binding]; other site 234267018186 putative metal binding site B [ion binding]; other site 234267018187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267018188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267018189 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 234267018190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267018191 putative NAD(P) binding site [chemical binding]; other site 234267018192 oxidoreductase; Provisional; Region: PRK06196 234267018193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267018194 NAD(P) binding site [chemical binding]; other site 234267018195 active site 234267018196 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267018197 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267018198 active site 234267018199 catalytic tetrad [active] 234267018200 hypothetical protein; Provisional; Region: PRK06184 234267018201 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234267018202 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 234267018203 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 234267018204 dimer interface [polypeptide binding]; other site 234267018205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267018206 ligand binding site [chemical binding]; other site 234267018207 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234267018208 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 234267018209 active site 234267018210 catalytic triad [active] 234267018211 dimer interface [polypeptide binding]; other site 234267018212 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267018213 Predicted esterase [General function prediction only]; Region: COG0627 234267018214 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267018215 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 234267018216 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 234267018217 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 234267018218 Walker A/P-loop; other site 234267018219 ATP binding site [chemical binding]; other site 234267018220 Q-loop/lid; other site 234267018221 ABC transporter signature motif; other site 234267018222 Walker B; other site 234267018223 D-loop; other site 234267018224 H-loop/switch region; other site 234267018225 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 234267018226 OstA-like protein; Region: OstA; cl00844 234267018227 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 234267018228 OstA-like protein; Region: OstA; cl00844 234267018229 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 234267018230 OstA-like protein; Region: OstA; cl00844 234267018231 Asparaginase; Region: Asparaginase; pfam00710 234267018232 active site 234267018233 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 234267018234 oligomerisation interface [polypeptide binding]; other site 234267018235 mobile loop; other site 234267018236 roof hairpin; other site 234267018237 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 234267018238 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 234267018239 ring oligomerisation interface [polypeptide binding]; other site 234267018240 ATP/Mg binding site [chemical binding]; other site 234267018241 stacking interactions; other site 234267018242 hinge regions; other site 234267018243 PAS domain S-box; Region: sensory_box; TIGR00229 234267018244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267018245 putative active site [active] 234267018246 heme pocket [chemical binding]; other site 234267018247 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 234267018248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267018249 putative active site [active] 234267018250 heme pocket [chemical binding]; other site 234267018251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267018252 putative active site [active] 234267018253 heme pocket [chemical binding]; other site 234267018254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267018255 dimer interface [polypeptide binding]; other site 234267018256 phosphorylation site [posttranslational modification] 234267018257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267018258 ATP binding site [chemical binding]; other site 234267018259 Mg2+ binding site [ion binding]; other site 234267018260 G-X-G motif; other site 234267018261 Response regulator receiver domain; Region: Response_reg; pfam00072 234267018262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018263 active site 234267018264 phosphorylation site [posttranslational modification] 234267018265 intermolecular recognition site; other site 234267018266 dimerization interface [polypeptide binding]; other site 234267018267 Putative amidotransferase; Region: DUF4066; pfam13278 234267018268 conserved cys residue [active] 234267018269 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267018270 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267018271 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234267018272 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234267018273 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267018274 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267018275 metal ion-dependent adhesion site (MIDAS); other site 234267018276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018277 Response regulator receiver domain; Region: Response_reg; pfam00072 234267018278 active site 234267018279 phosphorylation site [posttranslational modification] 234267018280 intermolecular recognition site; other site 234267018281 dimerization interface [polypeptide binding]; other site 234267018282 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234267018283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267018284 ATP binding site [chemical binding]; other site 234267018285 Mg2+ binding site [ion binding]; other site 234267018286 G-X-G motif; other site 234267018287 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234267018288 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 234267018289 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 234267018290 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234267018291 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267018292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267018293 catalytic residues [active] 234267018294 putative phosphate acyltransferase; Provisional; Region: PRK05331 234267018295 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 234267018296 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 234267018297 PEP-CTERM motif; Region: VPEP; pfam07589 234267018298 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 234267018299 protein translocase, SecG subunit; Region: secG; TIGR00810 234267018300 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267018301 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267018302 Family description; Region: VCBS; pfam13517 234267018303 Family description; Region: VCBS; pfam13517 234267018304 Family description; Region: VCBS; pfam13517 234267018305 Family description; Region: VCBS; pfam13517 234267018306 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 234267018307 Trp docking motif [polypeptide binding]; other site 234267018308 PQQ-like domain; Region: PQQ_2; pfam13360 234267018309 putative active site [active] 234267018310 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267018311 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267018312 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267018313 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267018314 active site pocket [active] 234267018315 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018316 Domain of unknown function (DUF1736); Region: DUF1736; pfam08409 234267018317 TPR repeat; Region: TPR_11; pfam13414 234267018318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018319 binding surface 234267018320 TPR motif; other site 234267018321 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 234267018322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018323 binding surface 234267018324 TPR motif; other site 234267018325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018326 binding surface 234267018327 TPR motif; other site 234267018328 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 234267018329 Carboxylesterase family; Region: COesterase; pfam00135 234267018330 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234267018331 substrate binding pocket [chemical binding]; other site 234267018332 catalytic triad [active] 234267018333 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267018334 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 234267018335 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267018337 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267018338 active site 234267018339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267018340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267018341 active site 234267018342 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267018343 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267018344 active site pocket [active] 234267018345 galactonate dehydratase; Provisional; Region: PRK14017 234267018346 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 234267018347 putative active site pocket [active] 234267018348 putative metal binding site [ion binding]; other site 234267018349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 234267018350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267018351 TPR motif; other site 234267018352 binding surface 234267018353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 234267018354 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 234267018355 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 234267018356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 234267018357 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267018358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018359 active site 234267018360 phosphorylation site [posttranslational modification] 234267018361 intermolecular recognition site; other site 234267018362 dimerization interface [polypeptide binding]; other site 234267018363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267018364 Walker A motif; other site 234267018365 ATP binding site [chemical binding]; other site 234267018366 Walker B motif; other site 234267018367 arginine finger; other site 234267018368 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267018369 sensory histidine kinase AtoS; Provisional; Region: PRK11360 234267018370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267018371 dimer interface [polypeptide binding]; other site 234267018372 phosphorylation site [posttranslational modification] 234267018373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267018374 ATP binding site [chemical binding]; other site 234267018375 Mg2+ binding site [ion binding]; other site 234267018376 G-X-G motif; other site 234267018377 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 234267018378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267018379 active site 234267018380 DNA binding site [nucleotide binding] 234267018381 Int/Topo IB signature motif; other site 234267018382 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 234267018383 mannose binding site [chemical binding]; other site 234267018384 D-mannose binding lectin; Region: B_lectin; pfam01453 234267018385 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 234267018386 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267018387 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 234267018388 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 234267018389 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 234267018390 Int/Topo IB signature motif; other site 234267018391 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267018392 active site 234267018393 DNA binding site [nucleotide binding] 234267018394 Int/Topo IB signature motif; other site 234267018395 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 234267018396 Integrase core domain; Region: rve; pfam00665 234267018397 DDE domain; Region: DDE_Tnp_IS240; pfam13610 234267018398 transposase/IS protein; Provisional; Region: PRK09183 234267018399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267018400 Walker A motif; other site 234267018401 ATP binding site [chemical binding]; other site 234267018402 Walker B motif; other site 234267018403 arginine finger; other site 234267018404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234267018405 Integrase core domain; Region: rve; pfam00665 234267018406 Integrase core domain; Region: rve_3; cl15866 234267018407 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 234267018408 TLC ATP/ADP transporter; Region: TLC; cl03940 234267018409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267018410 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267018411 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267018412 active site 234267018413 catalytic tetrad [active] 234267018414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267018415 PAS domain; Region: PAS_9; pfam13426 234267018416 putative active site [active] 234267018417 heme pocket [chemical binding]; other site 234267018418 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 234267018419 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 234267018420 active site 234267018421 DNA binding site [nucleotide binding] 234267018422 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 234267018423 DNA binding site [nucleotide binding] 234267018424 putative transposase OrfB; Reviewed; Region: PHA02517 234267018425 HTH-like domain; Region: HTH_21; pfam13276 234267018426 Integrase core domain; Region: rve; pfam00665 234267018427 Integrase core domain; Region: rve_3; pfam13683 234267018428 Transposase; Region: HTH_Tnp_1; pfam01527 234267018429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267018430 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267018431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018432 active site 234267018433 phosphorylation site [posttranslational modification] 234267018434 intermolecular recognition site; other site 234267018435 dimerization interface [polypeptide binding]; other site 234267018436 Response regulator receiver domain; Region: Response_reg; pfam00072 234267018437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018438 active site 234267018439 phosphorylation site [posttranslational modification] 234267018440 intermolecular recognition site; other site 234267018441 dimerization interface [polypeptide binding]; other site 234267018442 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018443 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018444 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018445 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267018446 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267018447 active site 234267018448 ATP binding site [chemical binding]; other site 234267018449 substrate binding site [chemical binding]; other site 234267018450 activation loop (A-loop); other site 234267018451 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018452 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267018454 Int/Topo IB signature motif; other site 234267018455 DNA binding site [nucleotide binding] 234267018456 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018457 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234267018458 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234267018459 active site 234267018460 TDP-binding site; other site 234267018461 acceptor substrate-binding pocket; other site 234267018462 homodimer interface [polypeptide binding]; other site 234267018463 HEPN domain; Region: HEPN; cl00824 234267018464 Winged helix-turn helix; Region: HTH_29; pfam13551 234267018465 Homeodomain-like domain; Region: HTH_32; pfam13565 234267018466 DDE superfamily endonuclease; Region: DDE_3; pfam13358 234267018467 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 234267018468 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234267018469 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267018470 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267018471 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267018472 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267018473 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267018474 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 234267018475 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234267018476 NHL repeat; Region: NHL; pfam01436 234267018477 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267018478 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267018479 active site 234267018480 ATP binding site [chemical binding]; other site 234267018481 substrate binding site [chemical binding]; other site 234267018482 activation loop (A-loop); other site 234267018483 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018484 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 234267018485 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234267018486 PYR/PP interface [polypeptide binding]; other site 234267018487 dimer interface [polypeptide binding]; other site 234267018488 TPP binding site [chemical binding]; other site 234267018489 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267018490 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 234267018491 TPP-binding site [chemical binding]; other site 234267018492 dimer interface [polypeptide binding]; other site 234267018493 Cytochrome c; Region: Cytochrom_C; pfam00034 234267018494 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 234267018495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267018496 motif II; other site 234267018497 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267018498 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267018499 active site 234267018500 ATP binding site [chemical binding]; other site 234267018501 substrate binding site [chemical binding]; other site 234267018502 activation loop (A-loop); other site 234267018503 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267018504 Cupin domain; Region: Cupin_2; pfam07883 234267018505 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018506 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 234267018507 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267018508 Sulfatase; Region: Sulfatase; cl17466 234267018509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018510 binding surface 234267018511 TPR motif; other site 234267018512 TPR repeat; Region: TPR_11; pfam13414 234267018513 CHAT domain; Region: CHAT; pfam12770 234267018514 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267018515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234267018516 Transposase; Region: HTH_Tnp_1; pfam01527 234267018517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267018518 putative transposase OrfB; Reviewed; Region: PHA02517 234267018519 HTH-like domain; Region: HTH_21; pfam13276 234267018520 Integrase core domain; Region: rve; pfam00665 234267018521 Integrase core domain; Region: rve_3; pfam13683 234267018522 Virulence-associated protein E; Region: VirE; pfam05272 234267018523 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 234267018524 Winged helix-turn helix; Region: HTH_29; pfam13551 234267018525 Homeodomain-like domain; Region: HTH_32; pfam13565 234267018526 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267018527 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 234267018528 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018529 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 234267018530 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018531 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 234267018532 metal binding site [ion binding]; metal-binding site 234267018533 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267018534 active site 234267018535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234267018536 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018537 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267018538 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 234267018539 TIGR03790 family protein; Region: TIGR03790 234267018540 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 234267018541 Interdomain contacts; other site 234267018542 Cytokine receptor motif; other site 234267018543 cyanophycin synthetase; Provisional; Region: PRK14016 234267018544 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 234267018545 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 234267018546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267018547 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 234267018548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267018549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018550 TPR motif; other site 234267018551 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267018552 binding surface 234267018553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267018555 binding surface 234267018556 TPR motif; other site 234267018557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267018558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018559 binding surface 234267018560 TPR motif; other site 234267018561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267018562 CHAT domain; Region: CHAT; pfam12770 234267018563 Low molecular weight phosphatase family; Region: LMWPc; cl00105 234267018564 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234267018565 active site 234267018566 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 234267018567 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 234267018568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267018569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018570 active site 234267018571 phosphorylation site [posttranslational modification] 234267018572 intermolecular recognition site; other site 234267018573 dimerization interface [polypeptide binding]; other site 234267018574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267018575 DNA binding site [nucleotide binding] 234267018576 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 234267018577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267018578 dimerization interface [polypeptide binding]; other site 234267018579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267018580 dimer interface [polypeptide binding]; other site 234267018581 phosphorylation site [posttranslational modification] 234267018582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267018583 ATP binding site [chemical binding]; other site 234267018584 Mg2+ binding site [ion binding]; other site 234267018585 G-X-G motif; other site 234267018586 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267018587 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267018588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 234267018589 Transposase; Region: DDE_Tnp_ISL3; pfam01610 234267018590 Protein of unknown function (DUF3738); Region: DUF3738; pfam12543 234267018591 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 234267018592 Cytochrome c; Region: Cytochrom_C; pfam00034 234267018593 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 234267018594 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 234267018595 Subunit I/III interface [polypeptide binding]; other site 234267018596 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234267018597 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 234267018598 D-pathway; other site 234267018599 Putative ubiquinol binding site [chemical binding]; other site 234267018600 Low-spin heme (heme b) binding site [chemical binding]; other site 234267018601 Putative water exit pathway; other site 234267018602 Binuclear center (heme o3/CuB) [ion binding]; other site 234267018603 K-pathway; other site 234267018604 Putative proton exit pathway; other site 234267018605 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 234267018606 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 234267018607 Cytochrome c; Region: Cytochrom_C; pfam00034 234267018608 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267018609 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 234267018610 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234267018611 substrate binding pocket [chemical binding]; other site 234267018612 membrane-bound complex binding site; other site 234267018613 hinge residues; other site 234267018614 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 234267018615 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 234267018616 Trp docking motif [polypeptide binding]; other site 234267018617 dimer interface [polypeptide binding]; other site 234267018618 active site 234267018619 small subunit binding site [polypeptide binding]; other site 234267018620 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 234267018621 dimanganese center [ion binding]; other site 234267018622 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 234267018623 dimerization interface [polypeptide binding]; other site 234267018624 metal binding site [ion binding]; metal-binding site 234267018625 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 234267018626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267018627 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 234267018628 Walker A/P-loop; other site 234267018629 ATP binding site [chemical binding]; other site 234267018630 Q-loop/lid; other site 234267018631 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234267018632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267018633 Walker A/P-loop; other site 234267018634 ATP binding site [chemical binding]; other site 234267018635 Q-loop/lid; other site 234267018636 ABC transporter signature motif; other site 234267018637 Walker B; other site 234267018638 D-loop; other site 234267018639 H-loop/switch region; other site 234267018640 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 234267018641 hypothetical protein; Provisional; Region: PRK08609 234267018642 metal binding triad [ion binding]; metal-binding site 234267018643 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 234267018644 active site 234267018645 Isochorismatase family; Region: Isochorismatase; pfam00857 234267018646 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 234267018647 catalytic triad [active] 234267018648 conserved cis-peptide bond; other site 234267018649 short chain dehydrogenase; Provisional; Region: PRK06701 234267018650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267018651 NAD(P) binding site [chemical binding]; other site 234267018652 active site 234267018653 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 234267018654 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234267018655 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 234267018656 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 234267018657 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 234267018658 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 234267018659 hydrogenase 2 large subunit; Provisional; Region: PRK10467 234267018660 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 234267018661 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 234267018662 hydrogenase maturation protease; Region: hydrog_prot; TIGR00072 234267018663 nickel binding site [ion binding]; other site 234267018664 HupF/HypC family; Region: HupF_HypC; pfam01455 234267018665 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 234267018666 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 234267018667 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 234267018668 dimerization interface [polypeptide binding]; other site 234267018669 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 234267018670 ATP binding site [chemical binding]; other site 234267018671 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 234267018672 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267018673 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267018674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234267018675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267018676 Walker A/P-loop; other site 234267018677 ATP binding site [chemical binding]; other site 234267018678 Q-loop/lid; other site 234267018679 ABC transporter signature motif; other site 234267018680 Walker B; other site 234267018681 D-loop; other site 234267018682 H-loop/switch region; other site 234267018683 Putative glucoamylase; Region: Glycoamylase; pfam10091 234267018684 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 234267018685 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 234267018686 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 234267018687 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 234267018688 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 234267018690 Putative glucoamylase; Region: Glycoamylase; pfam10091 234267018691 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018692 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267018693 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267018694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267018695 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 234267018696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 234267018697 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267018698 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234267018699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267018700 active site 234267018701 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 234267018702 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267018703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267018704 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 234267018705 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 234267018706 Walker A/P-loop; other site 234267018707 ATP binding site [chemical binding]; other site 234267018708 Q-loop/lid; other site 234267018709 ABC transporter signature motif; other site 234267018710 Walker B; other site 234267018711 D-loop; other site 234267018712 H-loop/switch region; other site 234267018713 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234267018714 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 234267018715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234267018716 Coenzyme A binding pocket [chemical binding]; other site 234267018717 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 234267018718 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234267018719 inhibitor-cofactor binding pocket; inhibition site 234267018720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267018721 catalytic residue [active] 234267018722 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234267018723 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 234267018724 Probable Catalytic site; other site 234267018725 metal-binding site 234267018726 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234267018727 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267018728 active site 234267018729 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 234267018730 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 234267018731 Protein export membrane protein; Region: SecD_SecF; cl14618 234267018732 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 234267018733 Protein export membrane protein; Region: SecD_SecF; cl14618 234267018734 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267018735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267018736 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267018737 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 234267018738 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 234267018739 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 234267018740 membrane ATPase/protein kinase; Provisional; Region: PRK09435 234267018741 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 234267018742 Walker A; other site 234267018743 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 234267018744 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 234267018745 active site 234267018746 substrate binding site [chemical binding]; other site 234267018747 coenzyme B12 binding site [chemical binding]; other site 234267018748 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 234267018749 B12 binding site [chemical binding]; other site 234267018750 cobalt ligand [ion binding]; other site 234267018751 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 234267018752 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 234267018753 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 234267018754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267018755 dimer interface [polypeptide binding]; other site 234267018756 substrate binding site [chemical binding]; other site 234267018757 metal binding site [ion binding]; metal-binding site 234267018758 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267018759 carboxyltransferase (CT) interaction site; other site 234267018760 biotinylation site [posttranslational modification]; other site 234267018761 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 234267018762 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234267018763 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234267018764 oxaloacetate decarboxylase; Provisional; Region: PRK12330 234267018765 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 234267018766 active site 234267018767 catalytic residues [active] 234267018768 metal binding site [ion binding]; metal-binding site 234267018769 homodimer binding site [polypeptide binding]; other site 234267018770 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 234267018771 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 234267018772 CoA binding domain; Region: CoA_binding; smart00881 234267018773 Flagellin N-methylase; Region: FliB; cl00497 234267018774 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 234267018775 active site 234267018776 catalytic triad [active] 234267018777 oxyanion hole [active] 234267018778 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 234267018779 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234267018780 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234267018781 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267018782 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267018783 Walker A/P-loop; other site 234267018784 ATP binding site [chemical binding]; other site 234267018785 Q-loop/lid; other site 234267018786 ABC transporter signature motif; other site 234267018787 Walker B; other site 234267018788 D-loop; other site 234267018789 H-loop/switch region; other site 234267018790 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 234267018791 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 234267018792 B12 binding site [chemical binding]; other site 234267018793 cobalt ligand [ion binding]; other site 234267018794 BCCT family transporter; Region: BCCT; cl00569 234267018795 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 234267018796 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 234267018797 TAP-like protein; Region: Abhydrolase_4; pfam08386 234267018798 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 234267018799 putative amphipathic alpha helix; other site 234267018800 SnoaL-like domain; Region: SnoaL_2; pfam12680 234267018801 carbon starvation protein A; Provisional; Region: PRK15015 234267018802 Carbon starvation protein CstA; Region: CstA; pfam02554 234267018803 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 234267018804 Response regulator receiver domain; Region: Response_reg; pfam00072 234267018805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018806 active site 234267018807 phosphorylation site [posttranslational modification] 234267018808 intermolecular recognition site; other site 234267018809 dimerization interface [polypeptide binding]; other site 234267018810 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 234267018811 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 234267018812 trimer interface [polypeptide binding]; other site 234267018813 active site 234267018814 substrate binding site [chemical binding]; other site 234267018815 CoA binding site [chemical binding]; other site 234267018816 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 234267018817 dihydrodipicolinate synthase; Region: dapA; TIGR00674 234267018818 dimer interface [polypeptide binding]; other site 234267018819 active site 234267018820 catalytic residue [active] 234267018821 dihydrodipicolinate reductase; Provisional; Region: PRK00048 234267018822 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 234267018823 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 234267018824 aspartate kinase III; Validated; Region: PRK09084 234267018825 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 234267018826 nucleotide binding site [chemical binding]; other site 234267018827 putative catalytic residues [active] 234267018828 aspartate binding site [chemical binding]; other site 234267018829 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 234267018830 dimer interface [polypeptide binding]; other site 234267018831 allosteric regulatory binding pocket; other site 234267018832 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 234267018833 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 234267018834 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234267018835 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 234267018836 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like_fungal; cd05652 234267018837 metal binding site [ion binding]; metal-binding site 234267018838 putative dimer interface [polypeptide binding]; other site 234267018839 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267018840 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 234267018841 substrate binding site [chemical binding]; other site 234267018842 dimer interface [polypeptide binding]; other site 234267018843 ATP binding site [chemical binding]; other site 234267018844 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267018845 B12 binding site [chemical binding]; other site 234267018846 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267018847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267018848 FeS/SAM binding site; other site 234267018849 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 234267018850 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234267018851 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 234267018852 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 234267018853 dimer interface [polypeptide binding]; other site 234267018854 PYR/PP interface [polypeptide binding]; other site 234267018855 TPP binding site [chemical binding]; other site 234267018856 substrate binding site [chemical binding]; other site 234267018857 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234267018858 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 234267018859 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 234267018860 TPP-binding site [chemical binding]; other site 234267018861 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 234267018862 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 234267018863 GxxExxY protein; Region: GxxExxY; TIGR04256 234267018864 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 234267018865 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 234267018866 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 234267018867 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 234267018868 RNA binding site [nucleotide binding]; other site 234267018869 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 234267018870 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 234267018871 putative active site [active] 234267018872 catalytic site [active] 234267018873 putative metal binding site [ion binding]; other site 234267018874 oligomer interface [polypeptide binding]; other site 234267018875 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018876 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267018877 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 234267018878 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 234267018879 putative active site [active] 234267018880 putative FMN binding site [chemical binding]; other site 234267018881 putative substrate binding site [chemical binding]; other site 234267018882 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 234267018883 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 234267018884 dimer interface [polypeptide binding]; other site 234267018885 PYR/PP interface [polypeptide binding]; other site 234267018886 TPP binding site [chemical binding]; other site 234267018887 substrate binding site [chemical binding]; other site 234267018888 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 234267018889 Domain of unknown function; Region: EKR; pfam10371 234267018890 4Fe-4S binding domain; Region: Fer4_6; pfam12837 234267018891 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 234267018892 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 234267018893 TPP-binding site [chemical binding]; other site 234267018894 dimer interface [polypeptide binding]; other site 234267018895 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234267018896 TIR domain; Region: TIR_2; pfam13676 234267018897 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267018898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267018899 FtsX-like permease family; Region: FtsX; pfam02687 234267018900 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267018901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234267018902 Histidine kinase; Region: His_kinase; pfam06580 234267018903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267018904 ATP binding site [chemical binding]; other site 234267018905 Mg2+ binding site [ion binding]; other site 234267018906 G-X-G motif; other site 234267018907 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234267018908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267018909 active site 234267018910 phosphorylation site [posttranslational modification] 234267018911 intermolecular recognition site; other site 234267018912 dimerization interface [polypeptide binding]; other site 234267018913 LytTr DNA-binding domain; Region: LytTR; smart00850 234267018914 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018915 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267018916 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267018917 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 234267018918 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267018919 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267018920 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267018921 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 234267018922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018923 binding surface 234267018924 TPR motif; other site 234267018925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267018926 TPR motif; other site 234267018927 binding surface 234267018928 Fic family protein [Function unknown]; Region: COG3177 234267018929 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 234267018930 Fic/DOC family; Region: Fic; pfam02661 234267018931 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234267018932 Domain of unknown function DUF20; Region: UPF0118; pfam01594 234267018933 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 234267018934 YceG-like family; Region: YceG; pfam02618 234267018935 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 234267018936 dimerization interface [polypeptide binding]; other site 234267018937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267018938 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234267018939 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 234267018940 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 234267018941 dimer interface [polypeptide binding]; other site 234267018942 active site 234267018943 glycine-pyridoxal phosphate binding site [chemical binding]; other site 234267018944 folate binding site [chemical binding]; other site 234267018945 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 234267018946 prolyl-tRNA synthetase; Provisional; Region: PRK09194 234267018947 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234267018948 motif 1; other site 234267018949 dimer interface [polypeptide binding]; other site 234267018950 motif 2; other site 234267018951 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 234267018952 putative deacylase active site [active] 234267018953 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 234267018954 anticodon binding site; other site 234267018955 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267018956 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267018957 active site 234267018958 ATP binding site [chemical binding]; other site 234267018959 substrate binding site [chemical binding]; other site 234267018960 activation loop (A-loop); other site 234267018961 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267018962 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267018963 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267018964 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267018965 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267018966 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267018967 DNA binding residues [nucleotide binding] 234267018968 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234267018969 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 234267018970 NIPSNAP; Region: NIPSNAP; pfam07978 234267018971 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018972 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267018973 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267018974 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267018975 Amidase; Region: Amidase; pfam01425 234267018976 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 234267018977 homoserine dehydrogenase; Provisional; Region: PRK06270 234267018978 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 234267018979 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 234267018980 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 234267018981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267018982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234267018983 putative substrate translocation pore; other site 234267018984 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234267018985 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 234267018986 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267018987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267018988 non-specific DNA binding site [nucleotide binding]; other site 234267018989 salt bridge; other site 234267018990 sequence-specific DNA binding site [nucleotide binding]; other site 234267018991 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 234267018992 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 234267018993 active site 234267018994 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 234267018995 generic binding surface II; other site 234267018996 generic binding surface I; other site 234267018997 DNA polymerase IV; Validated; Region: PRK03858 234267018998 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234267018999 Walker A motif; other site 234267019000 ATP binding site [chemical binding]; other site 234267019001 Walker B motif; other site 234267019002 PIN domain; Region: PIN_3; pfam13470 234267019003 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 234267019004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267019005 ATP binding site [chemical binding]; other site 234267019006 Mg2+ binding site [ion binding]; other site 234267019007 G-X-G motif; other site 234267019008 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 234267019009 ATP binding site [chemical binding]; other site 234267019010 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 234267019011 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267019012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267019013 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267019014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267019015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267019016 active site 234267019017 phosphorylation site [posttranslational modification] 234267019018 intermolecular recognition site; other site 234267019019 dimerization interface [polypeptide binding]; other site 234267019020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267019021 DNA binding site [nucleotide binding] 234267019022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267019023 dimerization interface [polypeptide binding]; other site 234267019024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267019025 dimer interface [polypeptide binding]; other site 234267019026 phosphorylation site [posttranslational modification] 234267019027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267019028 ATP binding site [chemical binding]; other site 234267019029 Mg2+ binding site [ion binding]; other site 234267019030 G-X-G motif; other site 234267019031 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 234267019032 putative active site [active] 234267019033 catalytic triad [active] 234267019034 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 234267019035 PA/protease or protease-like domain interface [polypeptide binding]; other site 234267019036 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 234267019037 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267019038 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267019039 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 234267019040 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 234267019041 dimer interface [polypeptide binding]; other site 234267019042 active site 234267019043 CoA binding pocket [chemical binding]; other site 234267019044 SprT-like family; Region: SprT-like; pfam10263 234267019045 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 234267019046 Flavoprotein; Region: Flavoprotein; pfam02441 234267019047 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 234267019048 Prephenate dehydratase; Region: PDT; pfam00800 234267019049 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 234267019050 putative L-Phe binding site [chemical binding]; other site 234267019051 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 234267019052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267019053 Walker A motif; other site 234267019054 ATP binding site [chemical binding]; other site 234267019055 Walker B motif; other site 234267019056 arginine finger; other site 234267019057 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 234267019058 NAD-dependent deacetylase; Provisional; Region: PRK00481 234267019059 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 234267019060 NAD+ binding site [chemical binding]; other site 234267019061 substrate binding site [chemical binding]; other site 234267019062 Zn binding site [ion binding]; other site 234267019063 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 234267019064 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267019065 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 234267019066 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 234267019067 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 234267019068 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 234267019069 Walker A; other site 234267019070 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 234267019071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267019072 dimer interface [polypeptide binding]; other site 234267019073 substrate binding site [chemical binding]; other site 234267019074 metal binding site [ion binding]; metal-binding site 234267019075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234267019076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234267019077 active site 234267019078 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267019079 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267019080 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 234267019081 YcfA-like protein; Region: YcfA; pfam07927 234267019082 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 234267019083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267019084 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267019085 Predicted acyl esterases [General function prediction only]; Region: COG2936 234267019086 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267019087 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 234267019088 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267019089 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267019090 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234267019091 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234267019092 catalytic residues [active] 234267019093 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267019094 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234267019095 phosphoglycolate phosphatase; Provisional; Region: PRK13222 234267019096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267019097 active site 234267019098 motif I; other site 234267019099 motif II; other site 234267019100 FtsH Extracellular; Region: FtsH_ext; pfam06480 234267019101 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 234267019102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267019103 Walker A motif; other site 234267019104 ATP binding site [chemical binding]; other site 234267019105 Walker B motif; other site 234267019106 arginine finger; other site 234267019107 Peptidase family M41; Region: Peptidase_M41; pfam01434 234267019108 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 234267019109 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 234267019110 TilS substrate C-terminal domain; Region: TilS_C; smart00977 234267019111 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267019112 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 234267019113 putative NAD(P) binding site [chemical binding]; other site 234267019114 active site 234267019115 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 234267019116 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 234267019117 PIN domain; Region: PIN_3; cl17397 234267019118 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 234267019119 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267019120 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 234267019121 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 234267019122 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234267019123 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 234267019124 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 234267019125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234267019126 substrate binding site [chemical binding]; other site 234267019127 ATP binding site [chemical binding]; other site 234267019128 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 234267019129 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234267019130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234267019131 Beta-lactamase; Region: Beta-lactamase; pfam00144 234267019132 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 234267019133 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267019134 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267019135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234267019136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234267019137 DNA binding site [nucleotide binding] 234267019138 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267019139 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 234267019140 putative active site [active] 234267019141 metal binding site [ion binding]; metal-binding site 234267019142 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 234267019143 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 234267019144 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 234267019145 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 234267019146 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 234267019147 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 234267019148 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 234267019149 putative active site [active] 234267019150 catalytic residue [active] 234267019151 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 234267019152 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 234267019153 5S rRNA interface [nucleotide binding]; other site 234267019154 CTC domain interface [polypeptide binding]; other site 234267019155 L16 interface [polypeptide binding]; other site 234267019156 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 234267019157 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 234267019158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267019159 active site 234267019160 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 234267019161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267019162 active site 234267019163 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 234267019164 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 234267019165 putative dimer interface [polypeptide binding]; other site 234267019166 FtsX-like permease family; Region: FtsX; pfam02687 234267019167 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234267019168 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267019169 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267019170 Walker A/P-loop; other site 234267019171 ATP binding site [chemical binding]; other site 234267019172 Q-loop/lid; other site 234267019173 ABC transporter signature motif; other site 234267019174 Walker B; other site 234267019175 D-loop; other site 234267019176 H-loop/switch region; other site 234267019177 Abhydrolase family; Region: Abhydrolase_7; pfam12715 234267019178 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267019179 Winged helix-turn helix; Region: HTH_29; pfam13551 234267019180 DNA-binding interface [nucleotide binding]; DNA binding site 234267019181 Homeodomain-like domain; Region: HTH_32; pfam13565 234267019182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267019183 Integrase core domain; Region: rve; pfam00665 234267019184 Integrase core domain; Region: rve_3; pfam13683 234267019185 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234267019186 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267019187 Walker A/P-loop; other site 234267019188 ATP binding site [chemical binding]; other site 234267019189 Q-loop/lid; other site 234267019190 ABC transporter signature motif; other site 234267019191 Walker B; other site 234267019192 D-loop; other site 234267019193 H-loop/switch region; other site 234267019194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 234267019195 Helix-turn-helix domain; Region: HTH_28; pfam13518 234267019196 Homeodomain-like domain; Region: HTH_32; pfam13565 234267019197 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 234267019198 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 234267019199 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 234267019200 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267019201 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019202 FtsX-like permease family; Region: FtsX; pfam02687 234267019203 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019204 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267019205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019206 FtsX-like permease family; Region: FtsX; pfam02687 234267019207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019208 FtsX-like permease family; Region: FtsX; pfam02687 234267019209 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267019210 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267019211 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 234267019212 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 234267019213 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 234267019214 FAD binding site [chemical binding]; other site 234267019215 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 234267019216 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 234267019217 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267019218 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267019219 Probable Catalytic site; other site 234267019220 metal-binding site 234267019221 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267019222 Ligand binding site; other site 234267019223 Putative Catalytic site; other site 234267019224 DXD motif; other site 234267019225 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 234267019226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019227 binding surface 234267019228 TPR motif; other site 234267019229 TPR repeat; Region: TPR_11; pfam13414 234267019230 TPR repeat; Region: TPR_11; pfam13414 234267019231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019232 binding surface 234267019233 TPR motif; other site 234267019234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267019235 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234267019236 Cupin domain; Region: Cupin_2; pfam07883 234267019237 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267019238 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267019239 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 234267019240 AIR carboxylase; Region: AIRC; smart01001 234267019241 PilZ domain; Region: PilZ; pfam07238 234267019242 Cupin domain; Region: Cupin_2; cl17218 234267019243 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234267019244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267019245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267019246 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234267019247 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 234267019248 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 234267019249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 234267019250 RIP metalloprotease RseP; Region: TIGR00054 234267019251 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 234267019252 active site 234267019253 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 234267019254 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 234267019255 protein binding site [polypeptide binding]; other site 234267019256 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 234267019257 putative substrate binding region [chemical binding]; other site 234267019258 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 234267019259 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 234267019260 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 234267019261 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 234267019262 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 234267019263 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267019264 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234267019265 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267019266 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267019267 catalytic residue [active] 234267019268 CAAX protease self-immunity; Region: Abi; pfam02517 234267019269 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 234267019270 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 234267019271 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 234267019272 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 234267019273 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 234267019274 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267019275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267019276 Walker A motif; other site 234267019277 ATP binding site [chemical binding]; other site 234267019278 Walker B motif; other site 234267019279 arginine finger; other site 234267019280 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267019281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267019282 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234267019283 Walker A motif; other site 234267019284 ATP binding site [chemical binding]; other site 234267019285 Walker B motif; other site 234267019286 arginine finger; other site 234267019287 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267019288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 234267019289 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267019290 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 234267019291 putative NAD(P) binding site [chemical binding]; other site 234267019292 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267019293 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267019294 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267019295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267019296 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267019297 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 234267019298 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 234267019299 DXD motif; other site 234267019300 Sulfatase; Region: Sulfatase; cl17466 234267019301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267019302 S-adenosylmethionine binding site [chemical binding]; other site 234267019303 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 234267019304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267019305 active site 234267019306 motif I; other site 234267019307 motif II; other site 234267019308 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267019309 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 234267019310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267019311 active site 234267019312 motif I; other site 234267019313 motif II; other site 234267019314 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267019315 Ligand binding site; other site 234267019316 Putative Catalytic site; other site 234267019317 DXD motif; other site 234267019318 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267019319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267019320 S-adenosylmethionine binding site [chemical binding]; other site 234267019321 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 234267019322 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 234267019323 active site 234267019324 catalytic residue [active] 234267019325 dimer interface [polypeptide binding]; other site 234267019326 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 234267019327 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234267019328 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234267019329 shikimate binding site; other site 234267019330 NAD(P) binding site [chemical binding]; other site 234267019331 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234267019332 Amidase; Region: Amidase; pfam01425 234267019333 Amidohydrolase; Region: Amidohydro_2; pfam04909 234267019334 L-type amino acid transporter; Region: 2A0308; TIGR00911 234267019335 Putative esterase; Region: Esterase; pfam00756 234267019336 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234267019337 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 234267019338 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 234267019339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 234267019340 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234267019341 YceI-like domain; Region: YceI; smart00867 234267019342 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 234267019343 active site 234267019344 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 234267019345 HEAT repeats; Region: HEAT_2; pfam13646 234267019346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019347 TPR motif; other site 234267019348 binding surface 234267019349 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267019350 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 234267019351 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 234267019352 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 234267019353 active site 234267019354 catalytic site [active] 234267019355 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267019356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267019357 active site 234267019358 ATP binding site [chemical binding]; other site 234267019359 substrate binding site [chemical binding]; other site 234267019360 activation loop (A-loop); other site 234267019361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019362 TPR motif; other site 234267019363 binding surface 234267019364 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234267019365 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267019366 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 234267019367 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 234267019368 NAD binding site [chemical binding]; other site 234267019369 ligand binding site [chemical binding]; other site 234267019370 catalytic site [active] 234267019371 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 234267019372 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 234267019373 putative active site [active] 234267019374 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267019375 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019376 FtsX-like permease family; Region: FtsX; pfam02687 234267019377 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019378 FtsX-like permease family; Region: FtsX; pfam02687 234267019379 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 234267019380 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 234267019381 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 234267019382 dimer interface [polypeptide binding]; other site 234267019383 catalytic triad [active] 234267019384 peroxidatic and resolving cysteines [active] 234267019385 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 234267019386 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 234267019387 catalytic residues [active] 234267019388 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234267019389 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234267019390 inhibitor site; inhibition site 234267019391 active site 234267019392 dimer interface [polypeptide binding]; other site 234267019393 catalytic residue [active] 234267019394 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267019395 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 234267019396 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267019397 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 234267019398 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 234267019399 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234267019400 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234267019401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019402 TPR motif; other site 234267019403 TPR repeat; Region: TPR_11; pfam13414 234267019404 binding surface 234267019405 TPR repeat; Region: TPR_11; pfam13414 234267019406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019407 binding surface 234267019408 TPR motif; other site 234267019409 TPR repeat; Region: TPR_11; pfam13414 234267019410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019411 binding surface 234267019412 TPR motif; other site 234267019413 TPR repeat; Region: TPR_11; pfam13414 234267019414 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234267019415 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 234267019416 metal binding triad; other site 234267019417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 234267019418 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 234267019419 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 234267019420 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 234267019421 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 234267019422 Nitrogen regulatory protein P-II; Region: P-II; smart00938 234267019423 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 234267019424 BON domain; Region: BON; pfam04972 234267019425 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 234267019426 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 234267019427 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267019428 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 234267019429 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267019430 metal binding site [ion binding]; metal-binding site 234267019431 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 234267019432 active site 234267019433 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234267019434 classical (c) SDRs; Region: SDR_c; cd05233 234267019435 NAD(P) binding site [chemical binding]; other site 234267019436 active site 234267019437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267019438 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 234267019439 putative active site [active] 234267019440 heme pocket [chemical binding]; other site 234267019441 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 234267019442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267019443 putative active site [active] 234267019444 heme pocket [chemical binding]; other site 234267019445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267019446 putative active site [active] 234267019447 heme pocket [chemical binding]; other site 234267019448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267019449 dimer interface [polypeptide binding]; other site 234267019450 phosphorylation site [posttranslational modification] 234267019451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267019452 ATP binding site [chemical binding]; other site 234267019453 Mg2+ binding site [ion binding]; other site 234267019454 G-X-G motif; other site 234267019455 Response regulator receiver domain; Region: Response_reg; pfam00072 234267019456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267019457 active site 234267019458 phosphorylation site [posttranslational modification] 234267019459 intermolecular recognition site; other site 234267019460 dimerization interface [polypeptide binding]; other site 234267019461 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 234267019462 inhibitor binding site; inhibition site 234267019463 catalytic motif [active] 234267019464 Catalytic residue [active] 234267019465 Active site flap [active] 234267019466 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234267019467 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 234267019468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267019469 FeS/SAM binding site; other site 234267019470 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267019471 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267019472 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267019473 pyruvate phosphate dikinase; Provisional; Region: PRK09279 234267019474 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 234267019475 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 234267019476 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 234267019477 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 234267019478 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234267019479 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 234267019480 motif 1; other site 234267019481 dimer interface [polypeptide binding]; other site 234267019482 active site 234267019483 motif 2; other site 234267019484 motif 3; other site 234267019485 Recombination protein O N terminal; Region: RecO_N; pfam11967 234267019486 Recombination protein O C terminal; Region: RecO_C; pfam02565 234267019487 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267019488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019489 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019490 FtsX-like permease family; Region: FtsX; pfam02687 234267019491 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267019492 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267019493 O-methyltransferase; Region: Methyltransf_2; pfam00891 234267019494 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234267019495 Winged helix-turn helix; Region: HTH_29; pfam13551 234267019496 DNA-binding interface [nucleotide binding]; DNA binding site 234267019497 Homeodomain-like domain; Region: HTH_32; pfam13565 234267019498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 234267019499 Integrase core domain; Region: rve; pfam00665 234267019500 Integrase core domain; Region: rve_3; pfam13683 234267019501 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234267019502 active site 234267019503 metal binding site [ion binding]; metal-binding site 234267019504 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234267019505 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234267019506 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267019507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267019508 FtsX-like permease family; Region: FtsX; pfam02687 234267019509 FtsX-like permease family; Region: FtsX; pfam02687 234267019510 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267019511 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267019512 hypothetical protein; Provisional; Region: PRK08201 234267019513 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 234267019514 metal binding site [ion binding]; metal-binding site 234267019515 putative dimer interface [polypeptide binding]; other site 234267019516 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234267019517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234267019518 catalytic loop [active] 234267019519 iron binding site [ion binding]; other site 234267019520 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234267019521 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234267019522 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267019523 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234267019524 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267019525 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234267019526 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267019527 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 234267019528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267019529 putative substrate translocation pore; other site 234267019530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234267019531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267019532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234267019533 dimerization interface [polypeptide binding]; other site 234267019534 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 234267019535 diiron binding motif [ion binding]; other site 234267019536 Uncharacterized conserved protein [Function unknown]; Region: COG1633 234267019537 CCC1-related protein family; Region: CCC1_like_1; cd02437 234267019538 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234267019539 catalytic core [active] 234267019540 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267019541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234267019542 dimerization interface [polypeptide binding]; other site 234267019543 putative DNA binding site [nucleotide binding]; other site 234267019544 putative Zn2+ binding site [ion binding]; other site 234267019545 putative transporter; Provisional; Region: PRK11660 234267019546 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234267019547 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234267019548 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 234267019549 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 234267019550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 234267019551 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234267019552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234267019553 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234267019554 TIGR03790 family protein; Region: TIGR03790 234267019555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234267019556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234267019557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234267019558 dimerization interface [polypeptide binding]; other site 234267019559 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 234267019560 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 234267019561 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234267019562 DNA-binding site [nucleotide binding]; DNA binding site 234267019563 RNA-binding motif; other site 234267019564 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 234267019565 rRNA binding site [nucleotide binding]; other site 234267019566 predicted 30S ribosome binding site; other site 234267019567 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 234267019568 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 234267019569 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234267019570 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234267019571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267019572 active site 234267019573 phosphorylation site [posttranslational modification] 234267019574 intermolecular recognition site; other site 234267019575 dimerization interface [polypeptide binding]; other site 234267019576 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 234267019577 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267019578 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267019579 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 234267019580 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 234267019581 active site 234267019582 substrate binding site [chemical binding]; other site 234267019583 FMN binding site [chemical binding]; other site 234267019584 putative catalytic residues [active] 234267019585 HEAT repeats; Region: HEAT_2; pfam13646 234267019586 HEAT repeats; Region: HEAT_2; pfam13646 234267019587 HEAT repeats; Region: HEAT_2; pfam13646 234267019588 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267019589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267019590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267019591 DNA binding residues [nucleotide binding] 234267019592 sulfite oxidase; Provisional; Region: PLN00177 234267019593 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 234267019594 Moco binding site; other site 234267019595 metal coordination site [ion binding]; other site 234267019596 dimerization interface [polypeptide binding]; other site 234267019597 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 234267019598 catalytic residues [active] 234267019599 dimer interface [polypeptide binding]; other site 234267019600 BNR repeat-like domain; Region: BNR_2; pfam13088 234267019601 Chain length determinant protein; Region: Wzz; cl15801 234267019602 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 234267019603 Moco binding site; other site 234267019604 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 234267019605 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 234267019606 G1 box; other site 234267019607 putative GEF interaction site [polypeptide binding]; other site 234267019608 GTP/Mg2+ binding site [chemical binding]; other site 234267019609 Switch I region; other site 234267019610 G2 box; other site 234267019611 G3 box; other site 234267019612 Switch II region; other site 234267019613 G4 box; other site 234267019614 G5 box; other site 234267019615 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 234267019616 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 234267019617 Transposase; Region: HTH_Tnp_1; cl17663 234267019618 putative transposase OrfB; Reviewed; Region: PHA02517 234267019619 HTH-like domain; Region: HTH_21; pfam13276 234267019620 Integrase core domain; Region: rve; pfam00665 234267019621 Integrase core domain; Region: rve_3; pfam13683 234267019622 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234267019623 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234267019624 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 234267019625 active site 234267019626 phosphate binding residues; other site 234267019627 catalytic residues [active] 234267019628 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 234267019629 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 234267019630 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 234267019631 CAAX protease self-immunity; Region: Abi; pfam02517 234267019632 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 234267019633 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234267019634 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234267019635 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 234267019636 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 234267019637 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234267019638 RNA binding surface [nucleotide binding]; other site 234267019639 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 234267019640 active site 234267019641 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267019642 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234267019643 metal ion-dependent adhesion site (MIDAS); other site 234267019644 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234267019645 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234267019646 Acylphosphatase; Region: Acylphosphatase; pfam00708 234267019647 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267019648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267019649 S-adenosylmethionine binding site [chemical binding]; other site 234267019650 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 234267019651 spermidine synthase; Provisional; Region: PRK03612 234267019652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267019653 S-adenosylmethionine binding site [chemical binding]; other site 234267019654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234267019655 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234267019656 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234267019657 active site residue [active] 234267019658 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 234267019659 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 234267019660 aspartate aminotransferase; Provisional; Region: PRK05764 234267019661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234267019662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267019663 homodimer interface [polypeptide binding]; other site 234267019664 catalytic residue [active] 234267019665 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 234267019666 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 234267019667 active site 234267019668 (T/H)XGH motif; other site 234267019669 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 234267019670 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234267019671 PYR/PP interface [polypeptide binding]; other site 234267019672 dimer interface [polypeptide binding]; other site 234267019673 TPP binding site [chemical binding]; other site 234267019674 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267019675 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 234267019676 TPP-binding site; other site 234267019677 dimer interface [polypeptide binding]; other site 234267019678 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 234267019679 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 234267019680 NAD binding site [chemical binding]; other site 234267019681 homodimer interface [polypeptide binding]; other site 234267019682 active site 234267019683 substrate binding site [chemical binding]; other site 234267019684 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 234267019685 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 234267019686 active site 234267019687 Zn binding site [ion binding]; other site 234267019688 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 234267019689 nudix motif; other site 234267019690 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 234267019691 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 234267019692 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 234267019693 active site 234267019694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267019695 Histidine kinase; Region: HisKA_3; pfam07730 234267019696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267019697 ATP binding site [chemical binding]; other site 234267019698 Mg2+ binding site [ion binding]; other site 234267019699 G-X-G motif; other site 234267019700 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267019701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267019702 S-adenosylmethionine binding site [chemical binding]; other site 234267019703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234267019704 active site 234267019705 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 234267019706 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234267019707 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267019708 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267019709 Putative zinc-finger; Region: zf-HC2; pfam13490 234267019710 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267019711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267019712 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234267019713 DNA binding residues [nucleotide binding] 234267019714 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 234267019715 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 234267019716 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267019717 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 234267019718 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 234267019719 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 234267019720 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 234267019721 active site 234267019722 dimer interface [polypeptide binding]; other site 234267019723 motif 1; other site 234267019724 motif 2; other site 234267019725 motif 3; other site 234267019726 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 234267019727 anticodon binding site; other site 234267019728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267019729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267019730 active site 234267019731 catalytic tetrad [active] 234267019732 hypothetical protein; Validated; Region: PRK07883 234267019733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267019734 active site 234267019735 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234267019736 catalytic tetrad [active] 234267019737 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 234267019738 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267019739 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267019740 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267019741 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 234267019742 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 234267019743 glutaminase active site [active] 234267019744 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 234267019745 dimer interface [polypeptide binding]; other site 234267019746 active site 234267019747 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 234267019748 dimer interface [polypeptide binding]; other site 234267019749 active site 234267019750 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 234267019751 glutamate racemase; Provisional; Region: PRK00865 234267019752 cell division protein FtsZ; Validated; Region: PRK09330 234267019753 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 234267019754 nucleotide binding site [chemical binding]; other site 234267019755 SulA interaction site; other site 234267019756 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 234267019757 Cell division protein FtsA; Region: FtsA; smart00842 234267019758 Cell division protein FtsA; Region: FtsA; pfam14450 234267019759 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 234267019760 Cell division protein FtsQ; Region: FtsQ; pfam03799 234267019761 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 234267019762 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234267019763 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234267019764 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234267019765 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 234267019766 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 234267019767 active site 234267019768 homodimer interface [polypeptide binding]; other site 234267019769 cell division protein FtsW; Region: ftsW; TIGR02614 234267019770 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 234267019771 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234267019772 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234267019773 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 234267019774 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 234267019775 Mg++ binding site [ion binding]; other site 234267019776 putative catalytic motif [active] 234267019777 putative substrate binding site [chemical binding]; other site 234267019778 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 234267019779 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234267019780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234267019781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234267019782 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 234267019783 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234267019784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234267019785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234267019786 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 234267019787 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 234267019788 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267019789 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 234267019790 MraW methylase family; Region: Methyltransf_5; cl17771 234267019791 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 234267019792 cell division protein MraZ; Reviewed; Region: PRK00326 234267019793 MraZ protein; Region: MraZ; pfam02381 234267019794 MraZ protein; Region: MraZ; pfam02381 234267019795 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267019796 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267019797 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 234267019798 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267019799 thiamine pyrophosphate protein; Provisional; Region: PRK08273 234267019800 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 234267019801 PYR/PP interface [polypeptide binding]; other site 234267019802 dimer interface [polypeptide binding]; other site 234267019803 tetramer interface [polypeptide binding]; other site 234267019804 TPP binding site [chemical binding]; other site 234267019805 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234267019806 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 234267019807 TPP-binding site [chemical binding]; other site 234267019808 HEAT repeats; Region: HEAT_2; pfam13646 234267019809 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234267019810 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 234267019811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267019812 FeS/SAM binding site; other site 234267019813 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 234267019814 thymidylate kinase; Validated; Region: tmk; PRK00698 234267019815 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 234267019816 TMP-binding site; other site 234267019817 ATP-binding site [chemical binding]; other site 234267019818 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 234267019819 DNA polymerase III subunit delta'; Validated; Region: PRK08485 234267019820 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267019821 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 234267019822 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 234267019823 hinge; other site 234267019824 active site 234267019825 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 234267019826 adenosine deaminase; Provisional; Region: PRK09358 234267019827 active site 234267019828 glycogen branching enzyme; Provisional; Region: PRK05402 234267019829 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 234267019830 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 234267019831 active site 234267019832 catalytic site [active] 234267019833 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 234267019834 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 234267019835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267019836 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234267019837 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234267019838 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267019839 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267019840 active site 234267019841 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 234267019842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267019843 Walker A motif; other site 234267019844 ATP binding site [chemical binding]; other site 234267019845 Walker B motif; other site 234267019846 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 234267019847 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234267019848 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 234267019849 active site 234267019850 HslU subunit interaction site [polypeptide binding]; other site 234267019851 L-aspartate oxidase; Provisional; Region: PRK06175 234267019852 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 234267019853 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 234267019854 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234267019855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234267019856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234267019857 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267019858 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267019859 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 234267019860 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 234267019861 active site 234267019862 dimer interface [polypeptide binding]; other site 234267019863 metal binding site [ion binding]; metal-binding site 234267019864 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 234267019865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267019866 S-adenosylmethionine binding site [chemical binding]; other site 234267019867 DinB superfamily; Region: DinB_2; pfam12867 234267019868 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 234267019869 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 234267019870 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 234267019871 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 234267019872 isocitrate dehydrogenase; Validated; Region: PRK06451 234267019873 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267019874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267019875 active site 234267019876 phosphorylation site [posttranslational modification] 234267019877 intermolecular recognition site; other site 234267019878 dimerization interface [polypeptide binding]; other site 234267019879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267019880 Walker A motif; other site 234267019881 ATP binding site [chemical binding]; other site 234267019882 Walker B motif; other site 234267019883 arginine finger; other site 234267019884 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267019885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267019886 HAMP domain; Region: HAMP; pfam00672 234267019887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267019888 ATP binding site [chemical binding]; other site 234267019889 G-X-G motif; other site 234267019890 Surface antigen; Region: Bac_surface_Ag; pfam01103 234267019891 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 234267019892 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 234267019893 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 234267019894 acyl-CoA synthetase; Validated; Region: PRK08162 234267019895 acyl-activating enzyme (AAE) consensus motif; other site 234267019896 putative active site [active] 234267019897 AMP binding site [chemical binding]; other site 234267019898 putative CoA binding site [chemical binding]; other site 234267019899 enoyl-CoA hydratase; Validated; Region: PRK08139 234267019900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234267019901 substrate binding site [chemical binding]; other site 234267019902 oxyanion hole (OAH) forming residues; other site 234267019903 trimer interface [polypeptide binding]; other site 234267019904 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 234267019905 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 234267019906 active site 234267019907 tetramer interface; other site 234267019908 RNase_H superfamily; Region: RNase_H_2; pfam13482 234267019909 Tetratrico peptide repeat; Region: TPR_5; pfam12688 234267019910 Uncharacterized conserved protein [Function unknown]; Region: COG3595 234267019911 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234267019912 CAAX protease self-immunity; Region: Abi; pfam02517 234267019913 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234267019914 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 234267019915 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234267019916 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234267019917 active site 234267019918 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234267019919 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234267019920 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 234267019921 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267019922 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267019923 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 234267019924 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 234267019925 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 234267019926 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 234267019927 Cna protein B-type domain; Region: Cna_B_2; pfam13715 234267019928 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267019929 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 234267019930 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267019931 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267019932 active site 234267019933 ATP binding site [chemical binding]; other site 234267019934 substrate binding site [chemical binding]; other site 234267019935 activation loop (A-loop); other site 234267019936 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267019937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019938 TPR motif; other site 234267019939 binding surface 234267019940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019941 TPR repeat; Region: TPR_11; pfam13414 234267019942 binding surface 234267019943 TPR motif; other site 234267019944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019945 binding surface 234267019946 TPR motif; other site 234267019947 TPR repeat; Region: TPR_11; pfam13414 234267019948 TPR repeat; Region: TPR_11; pfam13414 234267019949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267019950 binding surface 234267019951 TPR motif; other site 234267019952 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267019953 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267019954 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 234267019955 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 234267019956 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 234267019957 active site 234267019958 oxyanion hole [active] 234267019959 catalytic triad [active] 234267019960 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 234267019961 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 234267019962 active site 234267019963 oxyanion hole [active] 234267019964 catalytic triad [active] 234267019965 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 234267019966 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 234267019967 dimer interface [polypeptide binding]; other site 234267019968 active site 234267019969 CoA binding pocket [chemical binding]; other site 234267019970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234267019971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267019972 NAD(P) binding site [chemical binding]; other site 234267019973 active site 234267019974 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 234267019975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267019976 putative substrate translocation pore; other site 234267019977 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267019978 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267019979 active site 234267019980 ATP binding site [chemical binding]; other site 234267019981 substrate binding site [chemical binding]; other site 234267019982 activation loop (A-loop); other site 234267019983 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267019984 Melibiase; Region: Melibiase; pfam02065 234267019985 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 234267019986 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 234267019987 30S subunit binding site; other site 234267019988 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 234267019989 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 234267019990 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 234267019991 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 234267019992 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 234267019993 alanine racemase; Reviewed; Region: alr; PRK00053 234267019994 active site 234267019995 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234267019996 dimer interface [polypeptide binding]; other site 234267019997 substrate binding site [chemical binding]; other site 234267019998 catalytic residues [active] 234267019999 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 234267020000 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 234267020001 ATP binding site [chemical binding]; other site 234267020002 Walker A motif; other site 234267020003 hexamer interface [polypeptide binding]; other site 234267020004 Walker B motif; other site 234267020005 DinB family; Region: DinB; cl17821 234267020006 DinB superfamily; Region: DinB_2; pfam12867 234267020007 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 234267020008 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 234267020009 putative Iron-sulfur protein interface [polypeptide binding]; other site 234267020010 proximal heme binding site [chemical binding]; other site 234267020011 distal heme binding site [chemical binding]; other site 234267020012 putative dimer interface [polypeptide binding]; other site 234267020013 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 234267020014 L-aspartate oxidase; Provisional; Region: PRK06175 234267020015 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 234267020016 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 234267020017 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 234267020018 PilZ domain; Region: PilZ; pfam07238 234267020019 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 234267020020 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267020021 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 234267020022 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 234267020023 active site 234267020024 catalytic site [active] 234267020025 substrate binding site [chemical binding]; other site 234267020026 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 234267020027 active site 234267020028 metal-binding site 234267020029 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 234267020030 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 234267020031 Sporulation related domain; Region: SPOR; pfam05036 234267020032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267020033 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 234267020034 Walker A motif; other site 234267020035 ATP binding site [chemical binding]; other site 234267020036 Walker B motif; other site 234267020037 arginine finger; other site 234267020038 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234267020039 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234267020040 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267020041 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 234267020042 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 234267020043 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267020044 RmuC family; Region: RmuC; pfam02646 234267020045 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234267020046 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 234267020047 generic binding surface I; other site 234267020048 generic binding surface II; other site 234267020049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234267020050 Zn2+ binding site [ion binding]; other site 234267020051 Mg2+ binding site [ion binding]; other site 234267020052 SurA N-terminal domain; Region: SurA_N; pfam09312 234267020053 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 234267020054 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 234267020055 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 234267020056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267020057 ATP binding site [chemical binding]; other site 234267020058 putative Mg++ binding site [ion binding]; other site 234267020059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267020060 nucleotide binding region [chemical binding]; other site 234267020061 ATP-binding site [chemical binding]; other site 234267020062 TRCF domain; Region: TRCF; pfam03461 234267020063 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 234267020064 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 234267020065 active site 234267020066 nucleotide binding site [chemical binding]; other site 234267020067 HIGH motif; other site 234267020068 KMSKS motif; other site 234267020069 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234267020070 active site residue [active] 234267020071 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 234267020072 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 234267020073 hinge; other site 234267020074 active site 234267020075 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 234267020076 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 234267020077 putative active site [active] 234267020078 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 234267020079 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234267020080 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 234267020081 NADP binding site [chemical binding]; other site 234267020082 dimer interface [polypeptide binding]; other site 234267020083 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 234267020084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267020085 putative active site [active] 234267020086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267020087 dimer interface [polypeptide binding]; other site 234267020088 phosphorylation site [posttranslational modification] 234267020089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267020090 ATP binding site [chemical binding]; other site 234267020091 Mg2+ binding site [ion binding]; other site 234267020092 G-X-G motif; other site 234267020093 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234267020094 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 234267020095 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 234267020096 active site 234267020097 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 234267020098 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 234267020099 Walker A/P-loop; other site 234267020100 ATP binding site [chemical binding]; other site 234267020101 Q-loop/lid; other site 234267020102 ABC transporter signature motif; other site 234267020103 Walker B; other site 234267020104 D-loop; other site 234267020105 H-loop/switch region; other site 234267020106 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 234267020107 putative carbohydrate binding site [chemical binding]; other site 234267020108 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267020109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267020110 S-adenosylmethionine binding site [chemical binding]; other site 234267020111 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267020112 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267020113 Probable Catalytic site; other site 234267020114 metal-binding site 234267020115 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267020116 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 234267020117 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267020118 Ligand binding site; other site 234267020119 Putative Catalytic site; other site 234267020120 DXD motif; other site 234267020121 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267020122 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267020123 Probable Catalytic site; other site 234267020124 metal-binding site 234267020125 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234267020126 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267020127 active site 234267020128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234267020129 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234267020130 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234267020131 Probable Catalytic site; other site 234267020132 metal-binding site 234267020133 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267020134 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234267020135 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234267020136 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 234267020137 acyl-activating enzyme (AAE) consensus motif; other site 234267020138 putative AMP binding site [chemical binding]; other site 234267020139 putative active site [active] 234267020140 putative CoA binding site [chemical binding]; other site 234267020141 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234267020142 Ligand Binding Site [chemical binding]; other site 234267020143 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234267020144 Ligand Binding Site [chemical binding]; other site 234267020145 FlaG protein; Region: FlaG; pfam03646 234267020146 Flagellar protein FliS; Region: FliS; cl00654 234267020147 Rod binding protein; Region: Rod-binding; cl01626 234267020148 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 234267020149 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 234267020150 Flagellar L-ring protein; Region: FlgH; cl17277 234267020151 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 234267020152 SAF-like; Region: SAF_2; pfam13144 234267020153 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 234267020154 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 234267020155 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 234267020156 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 234267020157 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 234267020158 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 234267020159 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 234267020160 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 234267020161 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 234267020162 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 234267020163 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 234267020164 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 234267020165 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 234267020166 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 234267020167 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 234267020168 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 234267020169 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 234267020170 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 234267020171 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 234267020172 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 234267020173 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 234267020174 FHIPEP family; Region: FHIPEP; pfam00771 234267020175 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 234267020176 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267020177 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 234267020178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267020179 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234267020180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267020181 DNA binding residues [nucleotide binding] 234267020182 flagellar motor switch protein FliN; Region: fliN; TIGR02480 234267020183 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 234267020184 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 234267020185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267020186 binding surface 234267020187 TPR motif; other site 234267020188 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 234267020189 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 234267020190 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 234267020191 putative NAD(P) binding site [chemical binding]; other site 234267020192 putative active site [active] 234267020193 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 234267020194 arylsulfatase; Provisional; Region: PRK13759 234267020195 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234267020196 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 234267020197 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 234267020198 active site 234267020199 homodimer interface [polypeptide binding]; other site 234267020200 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 234267020201 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234267020202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267020203 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267020204 ABC transporter; Region: ABC_tran_2; pfam12848 234267020205 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234267020206 CAAX protease self-immunity; Region: Abi; cl00558 234267020207 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 234267020208 active site 234267020209 catalytic triad [active] 234267020210 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 234267020211 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234267020212 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 234267020213 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234267020214 DNA binding residues [nucleotide binding] 234267020215 putative dimer interface [polypeptide binding]; other site 234267020216 chaperone protein DnaJ; Provisional; Region: PRK10767 234267020217 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234267020218 HSP70 interaction site [polypeptide binding]; other site 234267020219 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 234267020220 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 234267020221 dimer interface [polypeptide binding]; other site 234267020222 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 234267020223 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 234267020224 nucleotide binding site [chemical binding]; other site 234267020225 NEF interaction site [polypeptide binding]; other site 234267020226 SBD interface [polypeptide binding]; other site 234267020227 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 234267020228 putative active site [active] 234267020229 FOG: CBS domain [General function prediction only]; Region: COG0517 234267020230 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 234267020231 Flagellin N-methylase; Region: FliB; pfam03692 234267020232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 234267020233 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 234267020234 Radical SAM superfamily; Region: Radical_SAM; pfam04055 234267020235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267020236 FeS/SAM binding site; other site 234267020237 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234267020238 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234267020239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267020240 S-adenosylmethionine binding site [chemical binding]; other site 234267020241 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 234267020242 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 234267020243 Ligand binding site; other site 234267020244 Putative Catalytic site; other site 234267020245 DXD motif; other site 234267020246 putative glycosyl transferase; Provisional; Region: PRK10063 234267020247 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 234267020248 metal-binding site 234267020249 NAD synthetase; Provisional; Region: PRK13981 234267020250 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 234267020251 multimer interface [polypeptide binding]; other site 234267020252 active site 234267020253 catalytic triad [active] 234267020254 protein interface 1 [polypeptide binding]; other site 234267020255 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 234267020256 homodimer interface [polypeptide binding]; other site 234267020257 NAD binding pocket [chemical binding]; other site 234267020258 ATP binding pocket [chemical binding]; other site 234267020259 Mg binding site [ion binding]; other site 234267020260 active-site loop [active] 234267020261 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 234267020262 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234267020263 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234267020264 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 234267020265 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267020266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267020267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267020268 DNA binding residues [nucleotide binding] 234267020269 dimerization interface [polypeptide binding]; other site 234267020270 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 234267020271 TadE-like protein; Region: TadE; pfam07811 234267020272 TadE-like protein; Region: TadE; pfam07811 234267020273 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 234267020274 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267020275 B12 binding site [chemical binding]; other site 234267020276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267020277 FeS/SAM binding site; other site 234267020278 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 234267020279 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 234267020280 tetramer interface [polypeptide binding]; other site 234267020281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267020282 catalytic residue [active] 234267020283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020284 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267020285 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020286 FtsX-like permease family; Region: FtsX; pfam02687 234267020287 BNR repeat-like domain; Region: BNR_2; pfam13088 234267020288 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 234267020289 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267020290 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267020291 Outer membrane efflux protein; Region: OEP; pfam02321 234267020292 Outer membrane efflux protein; Region: OEP; pfam02321 234267020293 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 234267020294 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267020295 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 234267020296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267020298 active site 234267020299 ATP binding site [chemical binding]; other site 234267020300 substrate binding site [chemical binding]; other site 234267020301 activation loop (A-loop); other site 234267020302 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234267020303 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267020304 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234267020305 phosphopeptide binding site; other site 234267020306 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 234267020307 Protein phosphatase 2C; Region: PP2C; pfam00481 234267020308 active site 234267020309 Right handed beta helix region; Region: Beta_helix; pfam13229 234267020310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020311 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267020312 active site 234267020313 ATP binding site [chemical binding]; other site 234267020314 substrate binding site [chemical binding]; other site 234267020315 activation loop (A-loop); other site 234267020316 TPR repeat; Region: TPR_11; pfam13414 234267020317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267020318 TPR motif; other site 234267020319 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 234267020320 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234267020321 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 234267020322 phosphopeptide binding site; other site 234267020323 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267020324 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267020325 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267020326 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234267020327 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234267020328 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234267020329 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267020330 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234267020331 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 234267020332 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 234267020333 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 234267020334 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234267020335 putative NAD(P) binding site [chemical binding]; other site 234267020336 putative active site [active] 234267020337 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 234267020338 Fasciclin domain; Region: Fasciclin; pfam02469 234267020339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234267020340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267020341 non-specific DNA binding site [nucleotide binding]; other site 234267020342 salt bridge; other site 234267020343 sequence-specific DNA binding site [nucleotide binding]; other site 234267020344 Cupin domain; Region: Cupin_2; pfam07883 234267020345 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 234267020346 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 234267020347 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267020348 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234267020349 Metal-binding active site; metal-binding site 234267020350 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234267020351 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 234267020352 putative NAD(P) binding site [chemical binding]; other site 234267020353 catalytic Zn binding site [ion binding]; other site 234267020354 TMAO/DMSO reductase; Reviewed; Region: PRK05363 234267020355 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 234267020356 Moco binding site; other site 234267020357 metal coordination site [ion binding]; other site 234267020358 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 234267020359 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 234267020360 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234267020361 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 234267020362 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 234267020363 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 234267020364 GIY-YIG motif/motif A; other site 234267020365 active site 234267020366 catalytic site [active] 234267020367 metal binding site [ion binding]; metal-binding site 234267020368 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 234267020369 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234267020370 ATP binding site [chemical binding]; other site 234267020371 Mg++ binding site [ion binding]; other site 234267020372 motif III; other site 234267020373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267020374 nucleotide binding region [chemical binding]; other site 234267020375 ATP-binding site [chemical binding]; other site 234267020376 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267020377 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020378 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267020380 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234267020381 NAD(P) binding site [chemical binding]; other site 234267020382 active site 234267020383 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 234267020384 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234267020385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234267020386 active site 234267020387 catalytic tetrad [active] 234267020388 Transmembrane secretion effector; Region: MFS_3; pfam05977 234267020389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267020390 putative substrate translocation pore; other site 234267020391 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267020392 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267020393 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267020394 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020395 FtsX-like permease family; Region: FtsX; pfam02687 234267020396 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020397 FtsX-like permease family; Region: FtsX; pfam02687 234267020398 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 234267020399 Response regulator receiver domain; Region: Response_reg; pfam00072 234267020400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267020401 active site 234267020402 phosphorylation site [posttranslational modification] 234267020403 intermolecular recognition site; other site 234267020404 dimerization interface [polypeptide binding]; other site 234267020405 PAS fold; Region: PAS_4; pfam08448 234267020406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267020407 putative active site [active] 234267020408 heme pocket [chemical binding]; other site 234267020409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267020410 GAF domain; Region: GAF; pfam01590 234267020411 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267020412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267020413 putative active site [active] 234267020414 heme pocket [chemical binding]; other site 234267020415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267020416 dimer interface [polypeptide binding]; other site 234267020417 phosphorylation site [posttranslational modification] 234267020418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267020419 ATP binding site [chemical binding]; other site 234267020420 Mg2+ binding site [ion binding]; other site 234267020421 G-X-G motif; other site 234267020422 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 234267020423 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234267020424 Walker A motif; other site 234267020425 ATP binding site [chemical binding]; other site 234267020426 Walker B motif; other site 234267020427 KaiC; Region: KaiC; pfam06745 234267020428 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234267020429 ATP binding site [chemical binding]; other site 234267020430 Walker A motif; other site 234267020431 Walker B motif; other site 234267020432 PEP-CTERM motif; Region: VPEP; pfam07589 234267020433 PEP-CTERM motif; Region: VPEP; pfam07589 234267020434 pantothenate kinase; Reviewed; Region: PRK13318 234267020435 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 234267020436 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 234267020437 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 234267020438 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 234267020439 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 234267020440 dimerization interface [polypeptide binding]; other site 234267020441 active site 234267020442 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 234267020443 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234267020444 active site 234267020445 HIGH motif; other site 234267020446 nucleotide binding site [chemical binding]; other site 234267020447 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234267020448 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 234267020449 active site 234267020450 KMSKS motif; other site 234267020451 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 234267020452 tRNA binding surface [nucleotide binding]; other site 234267020453 anticodon binding site; other site 234267020454 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 234267020455 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267020456 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267020457 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267020458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020459 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020460 FtsX-like permease family; Region: FtsX; pfam02687 234267020461 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234267020462 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234267020463 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234267020464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267020465 S-adenosylmethionine binding site [chemical binding]; other site 234267020466 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 234267020467 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 234267020468 heme-binding residues [chemical binding]; other site 234267020469 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 234267020470 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234267020471 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267020472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267020473 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267020474 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 234267020475 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020476 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020477 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020478 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020479 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020481 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267020482 active site 234267020483 ATP binding site [chemical binding]; other site 234267020484 substrate binding site [chemical binding]; other site 234267020485 activation loop (A-loop); other site 234267020486 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 234267020487 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267020488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267020489 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 234267020490 active site 234267020491 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 234267020492 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234267020493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234267020494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234267020495 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234267020496 glucose-1-dehydrogenase; Provisional; Region: PRK08936 234267020497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267020498 NAD(P) binding site [chemical binding]; other site 234267020499 active site 234267020500 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234267020501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267020502 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234267020503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267020504 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 234267020505 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 234267020506 Cytochrome c; Region: Cytochrom_C; pfam00034 234267020507 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234267020508 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234267020509 D-pathway; other site 234267020510 Putative ubiquinol binding site [chemical binding]; other site 234267020511 Low-spin heme (heme b) binding site [chemical binding]; other site 234267020512 Putative water exit pathway; other site 234267020513 Binuclear center (heme o3/CuB) [ion binding]; other site 234267020514 K-pathway; other site 234267020515 Putative proton exit pathway; other site 234267020516 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 234267020517 Subunit I/III interface [polypeptide binding]; other site 234267020518 Cytochrome c; Region: Cytochrom_C; pfam00034 234267020519 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267020520 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234267020521 Cytochrome c; Region: Cytochrom_C; pfam00034 234267020522 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234267020523 iron-sulfur cluster [ion binding]; other site 234267020524 [2Fe-2S] cluster binding site [ion binding]; other site 234267020525 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 234267020526 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 234267020527 intrachain domain interface; other site 234267020528 interchain domain interface [polypeptide binding]; other site 234267020529 heme bH binding site [chemical binding]; other site 234267020530 Qi binding site; other site 234267020531 heme bL binding site [chemical binding]; other site 234267020532 Qo binding site; other site 234267020533 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234267020534 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 234267020535 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 234267020536 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267020537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267020538 binding surface 234267020539 TPR motif; other site 234267020540 Family description; Region: VCBS; pfam13517 234267020541 Family description; Region: VCBS; pfam13517 234267020542 Family description; Region: VCBS; pfam13517 234267020543 Family description; Region: VCBS; pfam13517 234267020544 Family description; Region: VCBS; pfam13517 234267020545 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 234267020546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267020547 TPR motif; other site 234267020548 TPR repeat; Region: TPR_11; pfam13414 234267020549 binding surface 234267020550 TadE-like protein; Region: TadE; pfam07811 234267020551 TadE-like protein; Region: TadE; pfam07811 234267020552 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 234267020553 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 234267020554 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267020555 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234267020556 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 234267020557 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234267020558 Peptidase family M23; Region: Peptidase_M23; pfam01551 234267020559 rod shape-determining protein MreB; Provisional; Region: PRK13930 234267020560 MreB and similar proteins; Region: MreB_like; cd10225 234267020561 nucleotide binding site [chemical binding]; other site 234267020562 Mg binding site [ion binding]; other site 234267020563 putative protofilament interaction site [polypeptide binding]; other site 234267020564 RodZ interaction site [polypeptide binding]; other site 234267020565 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234267020566 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 234267020567 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 234267020568 DnaA box-binding interface [nucleotide binding]; other site 234267020569 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 234267020570 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 234267020571 active site 234267020572 catalytic site [active] 234267020573 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267020574 Integrase core domain; Region: rve; pfam00665 234267020575 DDE domain; Region: DDE_Tnp_IS240; pfam13610 234267020576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267020577 active site 234267020578 phosphorylation site [posttranslational modification] 234267020579 intermolecular recognition site; other site 234267020580 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 234267020581 active site 234267020582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234267020583 Integrase core domain; Region: rve; pfam00665 234267020584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234267020585 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 234267020586 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 234267020587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267020588 Walker A motif; other site 234267020589 ATP binding site [chemical binding]; other site 234267020590 Walker B motif; other site 234267020591 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267020592 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020593 active site 234267020594 ATP binding site [chemical binding]; other site 234267020595 substrate binding site [chemical binding]; other site 234267020596 activation loop (A-loop); other site 234267020597 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267020598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267020599 DNA binding residues [nucleotide binding] 234267020600 Integrase core domain; Region: rve; pfam00665 234267020601 DDE domain; Region: DDE_Tnp_IS240; pfam13610 234267020602 DDE superfamily endonuclease; Region: DDE_3; pfam13358 234267020603 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 234267020604 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 234267020605 putative active site [active] 234267020606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267020608 active site 234267020609 ATP binding site [chemical binding]; other site 234267020610 substrate binding site [chemical binding]; other site 234267020611 activation loop (A-loop); other site 234267020612 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 234267020613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020614 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267020615 active site 234267020616 ATP binding site [chemical binding]; other site 234267020617 substrate binding site [chemical binding]; other site 234267020618 activation loop (A-loop); other site 234267020619 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 234267020620 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 234267020621 putative active site [active] 234267020622 putative NTP binding site [chemical binding]; other site 234267020623 putative nucleic acid binding site [nucleotide binding]; other site 234267020624 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 234267020625 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267020626 active site 234267020627 Int/Topo IB signature motif; other site 234267020628 DNA binding site [nucleotide binding] 234267020629 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234267020630 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 234267020631 Int/Topo IB signature motif; other site 234267020632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234267020633 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 234267020634 active site 234267020635 DNA binding site [nucleotide binding] 234267020636 Int/Topo IB signature motif; other site 234267020637 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 234267020638 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 234267020639 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 234267020640 Int/Topo IB signature motif; other site 234267020641 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 234267020642 Putative transposase; Region: Y2_Tnp; pfam04986 234267020643 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267020644 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 234267020645 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 234267020646 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 234267020647 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 234267020648 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 234267020649 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267020650 Cupin domain; Region: Cupin_2; cl17218 234267020651 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 234267020652 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 234267020653 dimer interface [polypeptide binding]; other site 234267020654 ssDNA binding site [nucleotide binding]; other site 234267020655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234267020656 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 234267020657 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 234267020658 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 234267020659 Na binding site [ion binding]; other site 234267020660 putative substrate binding site [chemical binding]; other site 234267020661 phenylhydantoinase; Validated; Region: PRK08323 234267020662 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 234267020663 tetramer interface [polypeptide binding]; other site 234267020664 active site 234267020665 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 234267020666 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 234267020667 homodimer interface [polypeptide binding]; other site 234267020668 active site 234267020669 FMN binding site [chemical binding]; other site 234267020670 substrate binding site [chemical binding]; other site 234267020671 4Fe-4S binding domain; Region: Fer4_6; pfam12837 234267020672 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 234267020673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234267020674 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 234267020675 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234267020676 inhibitor-cofactor binding pocket; inhibition site 234267020677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267020678 catalytic residue [active] 234267020679 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 234267020680 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 234267020681 putative active site [active] 234267020682 catalytic triad [active] 234267020683 multimer interface [polypeptide binding]; other site 234267020684 dimer interface [polypeptide binding]; other site 234267020685 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267020686 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 234267020687 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 234267020688 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 234267020689 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 234267020690 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234267020691 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267020692 Ycf48-like protein; Provisional; Region: PRK13684 234267020693 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 234267020694 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 234267020695 homodimer interface [polypeptide binding]; other site 234267020696 substrate-cofactor binding pocket; other site 234267020697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267020698 catalytic residue [active] 234267020699 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234267020700 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234267020701 catalytic residue [active] 234267020702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234267020703 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 234267020704 elongation factor G; Reviewed; Region: PRK12740 234267020705 G1 box; other site 234267020706 putative GEF interaction site [polypeptide binding]; other site 234267020707 GTP/Mg2+ binding site [chemical binding]; other site 234267020708 Switch I region; other site 234267020709 G2 box; other site 234267020710 G3 box; other site 234267020711 Switch II region; other site 234267020712 G4 box; other site 234267020713 G5 box; other site 234267020714 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 234267020715 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 234267020716 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 234267020717 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234267020718 Peptidase family M28; Region: Peptidase_M28; pfam04389 234267020719 metal binding site [ion binding]; metal-binding site 234267020720 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267020721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267020722 DNA binding residues [nucleotide binding] 234267020723 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234267020724 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020725 active site 234267020726 ATP binding site [chemical binding]; other site 234267020727 substrate binding site [chemical binding]; other site 234267020728 activation loop (A-loop); other site 234267020729 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020730 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020731 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020732 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 234267020733 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267020734 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267020735 active site 234267020736 ATP binding site [chemical binding]; other site 234267020737 substrate binding site [chemical binding]; other site 234267020738 activation loop (A-loop); other site 234267020739 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234267020740 Family description; Region: VCBS; pfam13517 234267020741 Family description; Region: VCBS; pfam13517 234267020742 Family description; Region: VCBS; pfam13517 234267020743 Family description; Region: VCBS; pfam13517 234267020744 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234267020745 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234267020746 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 234267020747 putative active site [active] 234267020748 homotetrameric interface [polypeptide binding]; other site 234267020749 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 234267020750 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 234267020751 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267020752 Walker A/P-loop; other site 234267020753 ATP binding site [chemical binding]; other site 234267020754 Q-loop/lid; other site 234267020755 ABC transporter signature motif; other site 234267020756 Walker B; other site 234267020757 D-loop; other site 234267020758 H-loop/switch region; other site 234267020759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234267020760 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234267020761 Walker A/P-loop; other site 234267020762 ATP binding site [chemical binding]; other site 234267020763 Q-loop/lid; other site 234267020764 ABC transporter signature motif; other site 234267020765 Walker B; other site 234267020766 D-loop; other site 234267020767 H-loop/switch region; other site 234267020768 Putative zinc-finger; Region: zf-HC2; pfam13490 234267020769 FecR protein; Region: FecR; pfam04773 234267020770 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267020771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267020772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267020773 DNA binding residues [nucleotide binding] 234267020774 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 234267020775 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 234267020776 TPP-binding site [chemical binding]; other site 234267020777 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 234267020778 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 234267020779 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 234267020780 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 234267020781 dimer interface [polypeptide binding]; other site 234267020782 PYR/PP interface [polypeptide binding]; other site 234267020783 TPP binding site [chemical binding]; other site 234267020784 substrate binding site [chemical binding]; other site 234267020785 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 234267020786 HEAT-like repeat; Region: HEAT_EZ; pfam13513 234267020787 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 234267020788 putative active site [active] 234267020789 arginine decarboxylase; Provisional; Region: PRK05354 234267020790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 234267020791 dimer interface [polypeptide binding]; other site 234267020792 active site 234267020793 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234267020794 catalytic residues [active] 234267020795 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 234267020796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 234267020797 Protein of unknown function (DUF433); Region: DUF433; pfam04255 234267020798 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 234267020799 putative ABC transporter; Region: ycf24; CHL00085 234267020800 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 234267020801 FeS assembly ATPase SufC; Region: sufC; TIGR01978 234267020802 Walker A/P-loop; other site 234267020803 ATP binding site [chemical binding]; other site 234267020804 Q-loop/lid; other site 234267020805 ABC transporter signature motif; other site 234267020806 Walker B; other site 234267020807 D-loop; other site 234267020808 H-loop/switch region; other site 234267020809 FeS assembly protein SufD; Region: sufD; TIGR01981 234267020810 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 234267020811 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234267020812 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 234267020813 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267020814 catalytic residue [active] 234267020815 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 234267020816 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 234267020817 trimerization site [polypeptide binding]; other site 234267020818 active site 234267020819 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 234267020820 Rrf2 family protein; Region: rrf2_super; TIGR00738 234267020821 Transcriptional regulator; Region: Rrf2; pfam02082 234267020822 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267020823 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020824 FtsX-like permease family; Region: FtsX; pfam02687 234267020825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267020826 FtsX-like permease family; Region: FtsX; pfam02687 234267020827 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267020828 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267020829 Protein of unknown function, DUF481; Region: DUF481; cl01213 234267020830 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267020831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267020832 TPR motif; other site 234267020833 binding surface 234267020834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267020835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267020836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267020837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267020838 SEFIR domain; Region: SEFIR; pfam08357 234267020839 Cna protein B-type domain; Region: Cna_B_2; pfam13715 234267020840 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 234267020841 PhoH-like protein; Region: PhoH; pfam02562 234267020842 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 234267020843 FOG: CBS domain [General function prediction only]; Region: COG0517 234267020844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234267020845 Transporter associated domain; Region: CorC_HlyC; smart01091 234267020846 GTPase Era; Reviewed; Region: era; PRK00089 234267020847 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 234267020848 G1 box; other site 234267020849 GTP/Mg2+ binding site [chemical binding]; other site 234267020850 Switch I region; other site 234267020851 G2 box; other site 234267020852 Switch II region; other site 234267020853 G3 box; other site 234267020854 G4 box; other site 234267020855 G5 box; other site 234267020856 KH domain; Region: KH_2; pfam07650 234267020857 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 234267020858 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234267020859 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 234267020860 nudix motif; other site 234267020861 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 234267020862 MutS domain III; Region: MutS_III; pfam05192 234267020863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234267020864 Walker A/P-loop; other site 234267020865 ATP binding site [chemical binding]; other site 234267020866 Q-loop/lid; other site 234267020867 ABC transporter signature motif; other site 234267020868 Walker B; other site 234267020869 D-loop; other site 234267020870 H-loop/switch region; other site 234267020871 Smr domain; Region: Smr; pfam01713 234267020872 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 234267020873 catalytic triad [active] 234267020874 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 234267020875 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 234267020876 GatB domain; Region: GatB_Yqey; smart00845 234267020877 ribonuclease PH; Reviewed; Region: rph; PRK00173 234267020878 Ribonuclease PH; Region: RNase_PH_bact; cd11362 234267020879 hexamer interface [polypeptide binding]; other site 234267020880 active site 234267020881 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 234267020882 active site 234267020883 dimerization interface [polypeptide binding]; other site 234267020884 MgtC family; Region: MgtC; pfam02308 234267020885 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267020886 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267020887 active site pocket [active] 234267020888 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 234267020889 Protein of unknown function (DUF763); Region: DUF763; pfam05559 234267020890 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 234267020891 ThiS interaction site; other site 234267020892 putative active site [active] 234267020893 tetramer interface [polypeptide binding]; other site 234267020894 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 234267020895 DNA topoisomerase III; Provisional; Region: PRK07726 234267020896 active site 234267020897 putative interdomain interaction site [polypeptide binding]; other site 234267020898 putative metal-binding site [ion binding]; other site 234267020899 putative nucleotide binding site [chemical binding]; other site 234267020900 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 234267020901 domain I; other site 234267020902 phosphate binding site [ion binding]; other site 234267020903 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 234267020904 domain II; other site 234267020905 domain III; other site 234267020906 nucleotide binding site [chemical binding]; other site 234267020907 DNA binding groove [nucleotide binding] 234267020908 catalytic site [active] 234267020909 domain IV; other site 234267020910 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 234267020911 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267020912 ATP binding site [chemical binding]; other site 234267020913 putative Mg++ binding site [ion binding]; other site 234267020914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267020915 nucleotide binding region [chemical binding]; other site 234267020916 ATP-binding site [chemical binding]; other site 234267020917 HRDC domain; Region: HRDC; pfam00570 234267020918 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 234267020919 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234267020920 B12 binding site [chemical binding]; other site 234267020921 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 234267020922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234267020923 FeS/SAM binding site; other site 234267020924 Cna protein B-type domain; Region: Cna_B_2; pfam13715 234267020925 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267020926 Cupin domain; Region: Cupin_2; cl17218 234267020927 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234267020928 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234267020929 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267020930 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234267020931 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267020932 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234267020933 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234267020934 DNA binding site [nucleotide binding] 234267020935 domain linker motif; other site 234267020936 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234267020937 dimerization interface [polypeptide binding]; other site 234267020938 ligand binding site [chemical binding]; other site 234267020939 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 234267020940 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 234267020941 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 234267020942 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267020943 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 234267020944 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 234267020945 ATP binding site [chemical binding]; other site 234267020946 Walker A motif; other site 234267020947 hexamer interface [polypeptide binding]; other site 234267020948 Walker B motif; other site 234267020949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267020950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 234267020951 active site 234267020952 phosphorylation site [posttranslational modification] 234267020953 dimerization interface [polypeptide binding]; other site 234267020954 AAA domain; Region: AAA_31; pfam13614 234267020955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234267020956 TadE-like protein; Region: TadE; pfam07811 234267020957 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 234267020958 TadE-like protein; Region: TadE; pfam07811 234267020959 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 234267020960 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 234267020961 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 234267020962 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 234267020963 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 234267020964 Flp/Fap pilin component; Region: Flp_Fap; cl01585 234267020965 TPR repeat; Region: TPR_11; pfam13414 234267020966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267020967 TPR motif; other site 234267020968 binding surface 234267020969 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 234267020970 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267020971 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267020972 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267020973 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 234267020974 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 234267020975 RNase E interface [polypeptide binding]; other site 234267020976 trimer interface [polypeptide binding]; other site 234267020977 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 234267020978 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 234267020979 RNase E interface [polypeptide binding]; other site 234267020980 trimer interface [polypeptide binding]; other site 234267020981 active site 234267020982 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 234267020983 putative nucleic acid binding region [nucleotide binding]; other site 234267020984 G-X-X-G motif; other site 234267020985 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 234267020986 RNA binding site [nucleotide binding]; other site 234267020987 domain interface; other site 234267020988 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 234267020989 16S/18S rRNA binding site [nucleotide binding]; other site 234267020990 S13e-L30e interaction site [polypeptide binding]; other site 234267020991 25S rRNA binding site [nucleotide binding]; other site 234267020992 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 234267020993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267020994 S-adenosylmethionine binding site [chemical binding]; other site 234267020995 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 234267020996 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 234267020997 generic binding surface II; other site 234267020998 ssDNA binding site; other site 234267020999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234267021000 ATP binding site [chemical binding]; other site 234267021001 putative Mg++ binding site [ion binding]; other site 234267021002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234267021003 nucleotide binding region [chemical binding]; other site 234267021004 ATP-binding site [chemical binding]; other site 234267021005 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234267021006 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 234267021007 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 234267021008 nucleotide binding pocket [chemical binding]; other site 234267021009 K-X-D-G motif; other site 234267021010 catalytic site [active] 234267021011 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 234267021012 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 234267021013 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 234267021014 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 234267021015 Dimer interface [polypeptide binding]; other site 234267021016 BRCT sequence motif; other site 234267021017 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 234267021018 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 234267021019 Protein of unknown function DUF72; Region: DUF72; pfam01904 234267021020 LytTr DNA-binding domain; Region: LytTR; smart00850 234267021021 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267021022 putative pectinesterase; Region: PLN02432; cl01911 234267021023 Pectinesterase; Region: Pectinesterase; pfam01095 234267021024 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 234267021025 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 234267021026 Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437 234267021027 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 234267021028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267021029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267021030 DNA binding residues [nucleotide binding] 234267021031 Putative zinc-finger; Region: zf-HC2; pfam13490 234267021032 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 234267021033 type II secretion system protein E; Region: type_II_gspE; TIGR02533 234267021034 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 234267021035 Walker A motif; other site 234267021036 ATP binding site [chemical binding]; other site 234267021037 Walker B motif; other site 234267021038 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 234267021039 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267021040 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234267021041 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 234267021042 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 234267021043 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 234267021044 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 234267021045 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 234267021046 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 234267021047 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 234267021048 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 234267021049 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 234267021050 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 234267021051 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 234267021052 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 234267021053 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 234267021054 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234267021055 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 234267021056 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 234267021057 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267021058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267021059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234267021060 DNA binding residues [nucleotide binding] 234267021061 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267021062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021063 Response regulator receiver domain; Region: Response_reg; pfam00072 234267021064 active site 234267021065 intermolecular recognition site; other site 234267021066 dimerization interface [polypeptide binding]; other site 234267021067 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234267021068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267021069 ATP binding site [chemical binding]; other site 234267021070 Mg2+ binding site [ion binding]; other site 234267021071 G-X-G motif; other site 234267021072 Ecotin; Region: Ecotin; pfam03974 234267021073 secondary substrate binding site; other site 234267021074 primary substrate binding site; other site 234267021075 inhibition loop; other site 234267021076 dimerization interface [polypeptide binding]; other site 234267021077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234267021078 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234267021079 NAD(P) binding site [chemical binding]; other site 234267021080 active site 234267021081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 234267021082 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 234267021083 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 234267021084 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 234267021085 NAD binding site [chemical binding]; other site 234267021086 homotetramer interface [polypeptide binding]; other site 234267021087 homodimer interface [polypeptide binding]; other site 234267021088 substrate binding site [chemical binding]; other site 234267021089 active site 234267021090 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 234267021091 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 234267021092 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 234267021093 apolar tunnel; other site 234267021094 heme binding site [chemical binding]; other site 234267021095 dimerization interface [polypeptide binding]; other site 234267021096 TIGR03790 family protein; Region: TIGR03790 234267021097 TIGR03790 family protein; Region: TIGR03790 234267021098 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 234267021099 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234267021100 putative active site [active] 234267021101 putative metal binding site [ion binding]; other site 234267021102 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 234267021103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234267021104 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234267021105 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 234267021106 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234267021107 carboxyltransferase (CT) interaction site; other site 234267021108 biotinylation site [posttranslational modification]; other site 234267021109 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 234267021110 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234267021111 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234267021112 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234267021113 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 234267021114 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267021115 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267021116 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 234267021117 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267021118 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 234267021119 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267021120 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267021121 active site 234267021122 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 234267021123 active site 234267021124 catalytic triad [active] 234267021125 oxyanion hole [active] 234267021126 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267021127 PQQ-like domain; Region: PQQ_2; pfam13360 234267021128 Trp docking motif [polypeptide binding]; other site 234267021129 active site 234267021130 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234267021131 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 234267021132 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 234267021133 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 234267021134 active site 234267021135 catalytic residues [active] 234267021136 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 234267021137 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 234267021138 Walker A/P-loop; other site 234267021139 ATP binding site [chemical binding]; other site 234267021140 Q-loop/lid; other site 234267021141 ABC transporter signature motif; other site 234267021142 Walker B; other site 234267021143 D-loop; other site 234267021144 H-loop/switch region; other site 234267021145 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 234267021146 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 234267021147 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234267021148 TM-ABC transporter signature motif; other site 234267021149 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234267021150 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 234267021151 TM-ABC transporter signature motif; other site 234267021152 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 234267021153 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 234267021154 ligand binding site [chemical binding]; other site 234267021155 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 234267021156 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 234267021157 dimer interface [polypeptide binding]; other site 234267021158 active site 234267021159 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 234267021160 putative active site [active] 234267021161 Zn binding site [ion binding]; other site 234267021162 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267021163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234267021164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234267021165 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 234267021166 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 234267021167 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267021168 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267021169 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267021170 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 234267021171 CHASE2 domain; Region: CHASE2; pfam05226 234267021172 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234267021173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234267021174 putative active site [active] 234267021175 heme pocket [chemical binding]; other site 234267021176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267021177 dimer interface [polypeptide binding]; other site 234267021178 phosphorylation site [posttranslational modification] 234267021179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267021180 ATP binding site [chemical binding]; other site 234267021181 Mg2+ binding site [ion binding]; other site 234267021182 G-X-G motif; other site 234267021183 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267021184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021185 active site 234267021186 phosphorylation site [posttranslational modification] 234267021187 intermolecular recognition site; other site 234267021188 dimerization interface [polypeptide binding]; other site 234267021189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267021190 Walker A motif; other site 234267021191 ATP binding site [chemical binding]; other site 234267021192 Walker B motif; other site 234267021193 arginine finger; other site 234267021194 FecR protein; Region: FecR; pfam04773 234267021195 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267021196 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267021197 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 234267021198 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 234267021199 putative DNA binding site [nucleotide binding]; other site 234267021200 putative homodimer interface [polypeptide binding]; other site 234267021201 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 234267021202 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 234267021203 active site 234267021204 DNA binding site [nucleotide binding] 234267021205 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 234267021206 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 234267021207 DNA binding site [nucleotide binding] 234267021208 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 234267021209 nucleotide binding site [chemical binding]; other site 234267021210 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 234267021211 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 234267021212 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 234267021213 acyl-activating enzyme (AAE) consensus motif; other site 234267021214 putative AMP binding site [chemical binding]; other site 234267021215 putative active site [active] 234267021216 putative CoA binding site [chemical binding]; other site 234267021217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234267021218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267021219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267021220 binding surface 234267021221 TPR motif; other site 234267021222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267021223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234267021224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234267021225 binding surface 234267021226 TPR motif; other site 234267021227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234267021228 cyclase homology domain; Region: CHD; cd07302 234267021229 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 234267021230 nucleotidyl binding site; other site 234267021231 metal binding site [ion binding]; metal-binding site 234267021232 dimer interface [polypeptide binding]; other site 234267021233 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267021234 TPR repeat; Region: TPR_11; pfam13414 234267021235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267021236 TPR motif; other site 234267021237 binding surface 234267021238 TPR repeat; Region: TPR_11; pfam13414 234267021239 TPR repeat; Region: TPR_11; pfam13414 234267021240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267021241 TPR motif; other site 234267021242 binding surface 234267021243 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 234267021244 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 234267021245 active site pocket [active] 234267021246 Creatinine amidohydrolase; Region: Creatininase; pfam02633 234267021247 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 234267021248 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 234267021249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267021250 Walker A motif; other site 234267021251 ATP binding site [chemical binding]; other site 234267021252 Walker B motif; other site 234267021253 arginine finger; other site 234267021254 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 234267021255 Predicted membrane protein [Function unknown]; Region: COG2323 234267021256 replicative DNA helicase; Region: DnaB; TIGR00665 234267021257 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 234267021258 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 234267021259 Walker A motif; other site 234267021260 ATP binding site [chemical binding]; other site 234267021261 Walker B motif; other site 234267021262 DNA binding loops [nucleotide binding] 234267021263 Uncharacterized conserved protein [Function unknown]; Region: COG1565 234267021264 RNA polymerase sigma factor; Provisional; Region: PRK12519 234267021265 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267021266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267021267 DNA binding residues [nucleotide binding] 234267021268 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 234267021269 Anti-sigma-K factor rskA; Region: RskA; pfam10099 234267021270 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 234267021271 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 234267021272 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 234267021273 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 234267021274 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234267021275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267021276 Histidine kinase; Region: HisKA_3; pfam07730 234267021277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267021278 ATP binding site [chemical binding]; other site 234267021279 Mg2+ binding site [ion binding]; other site 234267021280 G-X-G motif; other site 234267021281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267021282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021283 active site 234267021284 phosphorylation site [posttranslational modification] 234267021285 intermolecular recognition site; other site 234267021286 dimerization interface [polypeptide binding]; other site 234267021287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267021288 DNA binding residues [nucleotide binding] 234267021289 dimerization interface [polypeptide binding]; other site 234267021290 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234267021291 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234267021292 ligand binding site [chemical binding]; other site 234267021293 flexible hinge region; other site 234267021294 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 234267021295 putative switch regulator; other site 234267021296 non-specific DNA interactions [nucleotide binding]; other site 234267021297 DNA binding site [nucleotide binding] 234267021298 sequence specific DNA binding site [nucleotide binding]; other site 234267021299 putative cAMP binding site [chemical binding]; other site 234267021300 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 234267021301 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 234267021302 Class I aldolases; Region: Aldolase_Class_I; cl17187 234267021303 catalytic residue [active] 234267021304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267021305 dimer interface [polypeptide binding]; other site 234267021306 phosphorylation site [posttranslational modification] 234267021307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267021308 ATP binding site [chemical binding]; other site 234267021309 Mg2+ binding site [ion binding]; other site 234267021310 G-X-G motif; other site 234267021311 Response regulator receiver domain; Region: Response_reg; pfam00072 234267021312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021313 active site 234267021314 phosphorylation site [posttranslational modification] 234267021315 intermolecular recognition site; other site 234267021316 dimerization interface [polypeptide binding]; other site 234267021317 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 234267021318 tandem repeat interface [polypeptide binding]; other site 234267021319 oligomer interface [polypeptide binding]; other site 234267021320 active site residues [active] 234267021321 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 234267021322 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 234267021323 tandem repeat interface [polypeptide binding]; other site 234267021324 oligomer interface [polypeptide binding]; other site 234267021325 active site residues [active] 234267021326 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 234267021327 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234267021328 NodB motif; other site 234267021329 active site 234267021330 catalytic site [active] 234267021331 metal binding site [ion binding]; metal-binding site 234267021332 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234267021333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021334 active site 234267021335 phosphorylation site [posttranslational modification] 234267021336 intermolecular recognition site; other site 234267021337 dimerization interface [polypeptide binding]; other site 234267021338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267021339 Walker A motif; other site 234267021340 ATP binding site [chemical binding]; other site 234267021341 Walker B motif; other site 234267021342 arginine finger; other site 234267021343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234267021344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234267021345 dimerization interface [polypeptide binding]; other site 234267021346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234267021347 dimer interface [polypeptide binding]; other site 234267021348 phosphorylation site [posttranslational modification] 234267021349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267021350 ATP binding site [chemical binding]; other site 234267021351 Mg2+ binding site [ion binding]; other site 234267021352 G-X-G motif; other site 234267021353 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 234267021354 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234267021355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 234267021356 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234267021357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267021358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021359 active site 234267021360 phosphorylation site [posttranslational modification] 234267021361 intermolecular recognition site; other site 234267021362 dimerization interface [polypeptide binding]; other site 234267021363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267021364 DNA binding residues [nucleotide binding] 234267021365 dimerization interface [polypeptide binding]; other site 234267021366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267021367 Histidine kinase; Region: HisKA_3; pfam07730 234267021368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234267021369 ATP binding site [chemical binding]; other site 234267021370 Mg2+ binding site [ion binding]; other site 234267021371 G-X-G motif; other site 234267021372 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234267021373 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267021374 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267021375 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267021376 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267021377 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267021378 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234267021379 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234267021380 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 234267021381 FAD binding domain; Region: FAD_binding_4; pfam01565 234267021382 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 234267021383 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 234267021384 Uncharacterized conserved protein [Function unknown]; Region: COG1432 234267021385 LabA_like proteins; Region: LabA_like; cd06167 234267021386 putative metal binding site [ion binding]; other site 234267021387 OST-HTH/LOTUS domain; Region: OST-HTH; pfam12872 234267021388 OST-HTH/LOTUS domain; Region: OST-HTH; pfam12872 234267021389 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 234267021390 prephenate dehydrogenase; Validated; Region: PRK08507 234267021391 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 234267021392 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 234267021393 Chorismate mutase type II; Region: CM_2; smart00830 234267021394 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 234267021395 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 234267021396 substrate binding site [chemical binding]; other site 234267021397 active site 234267021398 catalytic residues [active] 234267021399 heterodimer interface [polypeptide binding]; other site 234267021400 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 234267021401 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 234267021402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234267021403 catalytic residue [active] 234267021404 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 234267021405 active site 234267021406 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 234267021407 active site 234267021408 ribulose/triose binding site [chemical binding]; other site 234267021409 phosphate binding site [ion binding]; other site 234267021410 substrate (anthranilate) binding pocket [chemical binding]; other site 234267021411 product (indole) binding pocket [chemical binding]; other site 234267021412 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 234267021413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 234267021414 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 234267021415 Protein of unknown function DUF58; Region: DUF58; pfam01882 234267021416 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 234267021417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234267021418 active site 234267021419 motif I; other site 234267021420 motif II; other site 234267021421 Cytochrome c; Region: Cytochrom_C; pfam00034 234267021422 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 234267021423 Cytochrome c; Region: Cytochrom_C; pfam00034 234267021424 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 234267021425 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 234267021426 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 234267021427 Protein of unknown function, DUF488; Region: DUF488; pfam04343 234267021428 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 234267021429 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 234267021430 Cl- selectivity filter; other site 234267021431 Cl- binding residues [ion binding]; other site 234267021432 pore gating glutamate residue; other site 234267021433 dimer interface [polypeptide binding]; other site 234267021434 FOG: CBS domain [General function prediction only]; Region: COG0517 234267021435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 234267021436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234267021437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234267021438 active site 234267021439 phosphorylation site [posttranslational modification] 234267021440 intermolecular recognition site; other site 234267021441 dimerization interface [polypeptide binding]; other site 234267021442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234267021443 DNA binding residues [nucleotide binding] 234267021444 dimerization interface [polypeptide binding]; other site 234267021445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234267021446 Histidine kinase; Region: HisKA_3; pfam07730 234267021447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 234267021448 ATP binding site [chemical binding]; other site 234267021449 Mg2+ binding site [ion binding]; other site 234267021450 G-X-G motif; other site 234267021451 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 234267021452 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 234267021453 dimer interface [polypeptide binding]; other site 234267021454 ssDNA binding site [nucleotide binding]; other site 234267021455 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234267021456 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 234267021457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267021458 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267021459 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234267021460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234267021461 putative substrate translocation pore; other site 234267021462 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 234267021463 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267021464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021465 FtsX-like permease family; Region: FtsX; pfam02687 234267021466 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021467 FtsX-like permease family; Region: FtsX; pfam02687 234267021468 Predicted transcriptional regulators [Transcription]; Region: COG1695 234267021469 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 234267021470 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267021471 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 234267021472 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234267021473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234267021474 Walker A motif; other site 234267021475 ATP binding site [chemical binding]; other site 234267021476 Walker B motif; other site 234267021477 arginine finger; other site 234267021478 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 234267021479 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 234267021480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267021481 DNA binding residues [nucleotide binding] 234267021482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234267021483 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234267021484 active site 234267021485 ATP binding site [chemical binding]; other site 234267021486 substrate binding site [chemical binding]; other site 234267021487 activation loop (A-loop); other site 234267021488 Predicted integral membrane protein [Function unknown]; Region: COG5616 234267021489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267021490 TPR motif; other site 234267021491 binding surface 234267021492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267021493 binding surface 234267021494 TPR motif; other site 234267021495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234267021496 TPR motif; other site 234267021497 binding surface 234267021498 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 234267021499 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 234267021500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234267021501 non-specific DNA binding site [nucleotide binding]; other site 234267021502 salt bridge; other site 234267021503 sequence-specific DNA binding site [nucleotide binding]; other site 234267021504 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 234267021505 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021506 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 234267021507 FtsX-like permease family; Region: FtsX; pfam02687 234267021508 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267021509 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267021510 Walker A/P-loop; other site 234267021511 ATP binding site [chemical binding]; other site 234267021512 Q-loop/lid; other site 234267021513 ABC transporter signature motif; other site 234267021514 Walker B; other site 234267021515 D-loop; other site 234267021516 H-loop/switch region; other site 234267021517 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 234267021518 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 234267021519 DXD motif; other site 234267021520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234267021521 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234267021522 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 234267021523 active site 234267021524 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234267021525 MarR family; Region: MarR_2; pfam12802 234267021526 acetyl-CoA synthetase; Provisional; Region: PRK00174 234267021527 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 234267021528 active site 234267021529 CoA binding site [chemical binding]; other site 234267021530 acyl-activating enzyme (AAE) consensus motif; other site 234267021531 AMP binding site [chemical binding]; other site 234267021532 acetate binding site [chemical binding]; other site 234267021533 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234267021534 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234267021535 NAD(P) binding site [chemical binding]; other site 234267021536 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 234267021537 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 234267021538 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 234267021539 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 234267021540 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 234267021541 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 234267021542 active site 234267021543 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 234267021544 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234267021545 Active Sites [active] 234267021546 shikimate kinase; Reviewed; Region: aroK; PRK00131 234267021547 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 234267021548 ligand-binding site [chemical binding]; other site 234267021549 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 234267021550 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 234267021551 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234267021552 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234267021553 HlyD family secretion protein; Region: HlyD_3; pfam13437 234267021554 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234267021555 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234267021556 Walker A/P-loop; other site 234267021557 ATP binding site [chemical binding]; other site 234267021558 Q-loop/lid; other site 234267021559 ABC transporter signature motif; other site 234267021560 Walker B; other site 234267021561 D-loop; other site 234267021562 H-loop/switch region; other site 234267021563 Putative zinc-finger; Region: zf-HC2; pfam13490 234267021564 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234267021565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234267021566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234267021567 DNA binding residues [nucleotide binding] 234267021568 tyrosine decarboxylase; Region: PLN02880 234267021569 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234267021570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234267021571 catalytic residue [active] 234267021572 Transposase; Region: HTH_Tnp_1; pfam01527 234267021573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234267021574 putative transposase OrfB; Reviewed; Region: PHA02517 234267021575 HTH-like domain; Region: HTH_21; pfam13276 234267021576 Integrase core domain; Region: rve; pfam00665 234267021577 Integrase core domain; Region: rve_3; pfam13683 234267021578 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267021579 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021580 FtsX-like permease family; Region: FtsX; pfam02687 234267021581 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021582 FtsX-like permease family; Region: FtsX; pfam02687 234267021583 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234267021584 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 234267021585 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 234267021586 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 234267021587 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234267021589 FtsX-like permease family; Region: FtsX; pfam02687