-- dump date 20140619_025513 -- class Genbank::misc_feature -- table misc_feature_note -- id note 412965000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 412965000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412965000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000004 Walker A motif; other site 412965000005 ATP binding site [chemical binding]; other site 412965000006 Walker B motif; other site 412965000007 arginine finger; other site 412965000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 412965000009 DnaA box-binding interface [nucleotide binding]; other site 412965000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 412965000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 412965000012 putative DNA binding surface [nucleotide binding]; other site 412965000013 dimer interface [polypeptide binding]; other site 412965000014 beta-clamp/clamp loader binding surface; other site 412965000015 beta-clamp/translesion DNA polymerase binding surface; other site 412965000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 412965000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965000018 ATP binding site [chemical binding]; other site 412965000019 Mg2+ binding site [ion binding]; other site 412965000020 G-X-G motif; other site 412965000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412965000022 anchoring element; other site 412965000023 dimer interface [polypeptide binding]; other site 412965000024 ATP binding site [chemical binding]; other site 412965000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 412965000026 active site 412965000027 putative metal-binding site [ion binding]; other site 412965000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412965000029 phosphoribulokinase; Provisional; Region: PRK15453 412965000030 active site 412965000031 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 412965000032 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 412965000033 HIGH motif; other site 412965000034 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412965000035 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965000036 active site 412965000037 KMSKS motif; other site 412965000038 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 412965000039 tRNA binding surface [nucleotide binding]; other site 412965000040 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 412965000041 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 412965000042 heterodimer interface [polypeptide binding]; other site 412965000043 active site 412965000044 FMN binding site [chemical binding]; other site 412965000045 homodimer interface [polypeptide binding]; other site 412965000046 substrate binding site [chemical binding]; other site 412965000047 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 412965000048 AAA domain; Region: AAA_26; pfam13500 412965000049 Stringent starvation protein B; Region: SspB; cl01120 412965000050 stringent starvation protein A; Provisional; Region: sspA; PRK09481 412965000051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965000052 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 412965000053 N-terminal domain interface [polypeptide binding]; other site 412965000054 dimer interface [polypeptide binding]; other site 412965000055 substrate binding pocket (H-site) [chemical binding]; other site 412965000056 Cytochrome c; Region: Cytochrom_C; cl11414 412965000057 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 412965000058 cytochrome b; Provisional; Region: CYTB; MTH00145 412965000059 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 412965000060 Qi binding site; other site 412965000061 intrachain domain interface; other site 412965000062 interchain domain interface [polypeptide binding]; other site 412965000063 heme bH binding site [chemical binding]; other site 412965000064 heme bL binding site [chemical binding]; other site 412965000065 Qo binding site; other site 412965000066 interchain domain interface [polypeptide binding]; other site 412965000067 intrachain domain interface; other site 412965000068 Qi binding site; other site 412965000069 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 412965000070 Qo binding site; other site 412965000071 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 412965000072 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 412965000073 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 412965000074 [2Fe-2S] cluster binding site [ion binding]; other site 412965000075 Protein of unknown function (DUF721); Region: DUF721; cl02324 412965000076 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 412965000077 DEAD/DEAH box helicase; Region: DEAD; pfam00270 412965000078 ATP binding site [chemical binding]; other site 412965000079 putative Mg++ binding site [ion binding]; other site 412965000080 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 412965000081 SEC-C motif; Region: SEC-C; pfam02810 412965000082 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 412965000083 active site 412965000084 substrate binding pocket [chemical binding]; other site 412965000085 dimer interface [polypeptide binding]; other site 412965000086 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 412965000087 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 412965000088 active site 412965000089 Riboflavin kinase; Region: Flavokinase; pfam01687 412965000090 homoserine O-succinyltransferase; Provisional; Region: PRK05368 412965000091 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 412965000092 proposed active site lysine [active] 412965000093 conserved cys residue [active] 412965000094 AAA domain; Region: AAA_17; cl17253 412965000095 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 412965000096 aminotransferase; Validated; Region: PRK08175 412965000097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412965000098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000099 homodimer interface [polypeptide binding]; other site 412965000100 catalytic residue [active] 412965000101 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 412965000102 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412965000103 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 412965000104 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 412965000105 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 412965000106 ATP binding site [chemical binding]; other site 412965000107 active site 412965000108 substrate binding site [chemical binding]; other site 412965000109 putative peptidase; Provisional; Region: PRK11649 412965000110 Peptidase family M23; Region: Peptidase_M23; pfam01551 412965000111 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 412965000112 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 412965000113 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 412965000114 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 412965000115 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 412965000116 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 412965000117 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 412965000118 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 412965000119 catalytic residue [active] 412965000120 putative FPP diphosphate binding site; other site 412965000121 putative FPP binding hydrophobic cleft; other site 412965000122 dimer interface [polypeptide binding]; other site 412965000123 putative IPP diphosphate binding site; other site 412965000124 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 412965000125 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 412965000126 substrate binding site [chemical binding]; other site 412965000127 glutamase interaction surface [polypeptide binding]; other site 412965000128 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 412965000129 UbiA prenyltransferase family; Region: UbiA; pfam01040 412965000130 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 412965000131 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 412965000132 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 412965000133 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 412965000134 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 412965000135 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 412965000136 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 412965000137 cytochrome c-550; Provisional; Region: psbV; cl17239 412965000138 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 412965000139 Cytochrome c; Region: Cytochrom_C; pfam00034 412965000140 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412965000141 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 412965000142 Subunit I/III interface [polypeptide binding]; other site 412965000143 D-pathway; other site 412965000144 Subunit I/VIIc interface [polypeptide binding]; other site 412965000145 Subunit I/IV interface [polypeptide binding]; other site 412965000146 Subunit I/II interface [polypeptide binding]; other site 412965000147 Low-spin heme (heme a) binding site [chemical binding]; other site 412965000148 Subunit I/VIIa interface [polypeptide binding]; other site 412965000149 Subunit I/VIa interface [polypeptide binding]; other site 412965000150 Dimer interface; other site 412965000151 Putative water exit pathway; other site 412965000152 Binuclear center (heme a3/CuB) [ion binding]; other site 412965000153 K-pathway; other site 412965000154 Subunit I/Vb interface [polypeptide binding]; other site 412965000155 Putative proton exit pathway; other site 412965000156 Subunit I/VIb interface; other site 412965000157 Subunit I/VIc interface [polypeptide binding]; other site 412965000158 Electron transfer pathway; other site 412965000159 Subunit I/VIIIb interface [polypeptide binding]; other site 412965000160 Subunit I/VIIb interface [polypeptide binding]; other site 412965000161 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 412965000162 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 412965000163 Subunit III/VIIa interface [polypeptide binding]; other site 412965000164 Phospholipid binding site [chemical binding]; other site 412965000165 Subunit I/III interface [polypeptide binding]; other site 412965000166 Subunit III/VIb interface [polypeptide binding]; other site 412965000167 Subunit III/VIa interface; other site 412965000168 Subunit III/Vb interface [polypeptide binding]; other site 412965000169 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 412965000170 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 412965000171 Low-spin heme binding site [chemical binding]; other site 412965000172 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 412965000173 D-pathway; other site 412965000174 Putative water exit pathway; other site 412965000175 Binuclear center (active site) [active] 412965000176 K-pathway; other site 412965000177 Putative proton exit pathway; other site 412965000178 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 412965000179 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 412965000180 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 412965000181 Cytochrome c; Region: Cytochrom_C; pfam00034 412965000182 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 412965000183 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 412965000184 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 412965000185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412965000186 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 412965000187 thioredoxin reductase; Provisional; Region: PRK10262 412965000188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412965000189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965000190 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 412965000191 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412965000192 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412965000193 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 412965000194 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 412965000195 Transglycosylase SLT domain; Region: SLT_2; pfam13406 412965000196 murein hydrolase B; Provisional; Region: PRK10760; cl17906 412965000197 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 412965000198 ApbE family; Region: ApbE; pfam02424 412965000199 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 412965000200 glutathione synthetase; Provisional; Region: PRK05246 412965000201 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 412965000202 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 412965000203 ribosome maturation protein RimP; Reviewed; Region: PRK00092 412965000204 Sm and related proteins; Region: Sm_like; cl00259 412965000205 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 412965000206 putative oligomer interface [polypeptide binding]; other site 412965000207 putative RNA binding site [nucleotide binding]; other site 412965000208 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 412965000209 NusA N-terminal domain; Region: NusA_N; pfam08529 412965000210 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 412965000211 RNA binding site [nucleotide binding]; other site 412965000212 homodimer interface [polypeptide binding]; other site 412965000213 NusA-like KH domain; Region: KH_5; pfam13184 412965000214 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 412965000215 G-X-X-G motif; other site 412965000216 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 412965000217 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 412965000218 translation initiation factor IF-2; Region: IF-2; TIGR00487 412965000219 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 412965000220 G1 box; other site 412965000221 putative GEF interaction site [polypeptide binding]; other site 412965000222 GTP/Mg2+ binding site [chemical binding]; other site 412965000223 Switch I region; other site 412965000224 G2 box; other site 412965000225 G3 box; other site 412965000226 Switch II region; other site 412965000227 G4 box; other site 412965000228 G5 box; other site 412965000229 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 412965000230 Translation-initiation factor 2; Region: IF-2; pfam11987 412965000231 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 412965000232 Ribosome-binding factor A; Region: RBFA; pfam02033 412965000233 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 412965000234 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 412965000235 RNA binding site [nucleotide binding]; other site 412965000236 active site 412965000237 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 412965000238 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 412965000239 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 412965000240 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 412965000241 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 412965000242 outer membrane lipoprotein; Provisional; Region: PRK11023 412965000243 Predicted methyltransferases [General function prediction only]; Region: COG0313 412965000244 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 412965000245 putative SAM binding site [chemical binding]; other site 412965000246 putative homodimer interface [polypeptide binding]; other site 412965000247 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 412965000248 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 412965000249 CoA-binding site [chemical binding]; other site 412965000250 ATP-binding [chemical binding]; other site 412965000251 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 412965000252 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 412965000253 Catalytic site; other site 412965000254 transketolase; Reviewed; Region: PRK12753 412965000255 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 412965000256 TPP-binding site [chemical binding]; other site 412965000257 dimer interface [polypeptide binding]; other site 412965000258 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412965000259 PYR/PP interface [polypeptide binding]; other site 412965000260 dimer interface [polypeptide binding]; other site 412965000261 TPP binding site [chemical binding]; other site 412965000262 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412965000263 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 412965000264 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 412965000265 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 412965000266 Phosphoglycerate kinase; Region: PGK; pfam00162 412965000267 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 412965000268 substrate binding site [chemical binding]; other site 412965000269 hinge regions; other site 412965000270 ADP binding site [chemical binding]; other site 412965000271 catalytic site [active] 412965000272 pyruvate kinase; Provisional; Region: PRK05826 412965000273 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 412965000274 domain interfaces; other site 412965000275 active site 412965000276 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 412965000277 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 412965000278 intersubunit interface [polypeptide binding]; other site 412965000279 active site 412965000280 zinc binding site [ion binding]; other site 412965000281 Na+ binding site [ion binding]; other site 412965000282 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 412965000283 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 412965000284 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 412965000285 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 412965000286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412965000287 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 412965000288 active site 412965000289 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 412965000290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412965000291 RNA binding surface [nucleotide binding]; other site 412965000292 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412965000293 active site 412965000294 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 412965000295 UbiA prenyltransferase family; Region: UbiA; pfam01040 412965000296 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 412965000297 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 412965000298 trimer interface [polypeptide binding]; other site 412965000299 active site 412965000300 substrate binding site [chemical binding]; other site 412965000301 CoA binding site [chemical binding]; other site 412965000302 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 412965000303 4Fe-4S binding domain; Region: Fer4_5; pfam12801 412965000304 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 412965000305 FixH; Region: FixH; pfam05751 412965000306 YtkA-like; Region: YtkA; pfam13115 412965000307 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 412965000308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965000309 Walker A/P-loop; other site 412965000310 ATP binding site [chemical binding]; other site 412965000311 Q-loop/lid; other site 412965000312 ABC transporter signature motif; other site 412965000313 Walker B; other site 412965000314 D-loop; other site 412965000315 H-loop/switch region; other site 412965000316 DNA polymerase I; Provisional; Region: PRK05755 412965000317 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 412965000318 active site 412965000319 metal binding site 1 [ion binding]; metal-binding site 412965000320 putative 5' ssDNA interaction site; other site 412965000321 metal binding site 3; metal-binding site 412965000322 metal binding site 2 [ion binding]; metal-binding site 412965000323 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 412965000324 putative DNA binding site [nucleotide binding]; other site 412965000325 putative metal binding site [ion binding]; other site 412965000326 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 412965000327 active site 412965000328 catalytic site [active] 412965000329 substrate binding site [chemical binding]; other site 412965000330 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 412965000331 active site 412965000332 DNA binding site [nucleotide binding] 412965000333 catalytic site [active] 412965000334 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 412965000335 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 412965000336 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965000337 active site 412965000338 HIGH motif; other site 412965000339 nucleotide binding site [chemical binding]; other site 412965000340 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 412965000341 KMSK motif region; other site 412965000342 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412965000343 tRNA binding surface [nucleotide binding]; other site 412965000344 anticodon binding site; other site 412965000345 Part of AAA domain; Region: AAA_19; pfam13245 412965000346 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 412965000347 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412965000348 thiamine phosphate binding site [chemical binding]; other site 412965000349 active site 412965000350 pyrophosphate binding site [ion binding]; other site 412965000351 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 412965000352 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 412965000353 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 412965000354 ATP-sulfurylase; Region: ATPS; cd00517 412965000355 active site 412965000356 HXXH motif; other site 412965000357 flexible loop; other site 412965000358 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 412965000359 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 412965000360 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 412965000361 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 412965000362 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412965000363 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 412965000364 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 412965000365 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 412965000366 adenylate kinase; Reviewed; Region: adk; PRK00279 412965000367 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 412965000368 AMP-binding site [chemical binding]; other site 412965000369 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 412965000370 6-phosphofructokinase; Provisional; Region: PRK14072 412965000371 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 412965000372 active site 412965000373 ADP/pyrophosphate binding site [chemical binding]; other site 412965000374 dimerization interface [polypeptide binding]; other site 412965000375 allosteric effector site; other site 412965000376 fructose-1,6-bisphosphate binding site; other site 412965000377 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 412965000378 active site 412965000379 metal binding site [ion binding]; metal-binding site 412965000380 homotetramer interface [polypeptide binding]; other site 412965000381 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 412965000382 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412965000383 active site 412965000384 HIGH motif; other site 412965000385 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412965000386 KMSKS motif; other site 412965000387 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 412965000388 tRNA binding surface [nucleotide binding]; other site 412965000389 anticodon binding site; other site 412965000390 peroxidase; Provisional; Region: PRK15000 412965000391 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 412965000392 dimer interface [polypeptide binding]; other site 412965000393 decamer (pentamer of dimers) interface [polypeptide binding]; other site 412965000394 catalytic triad [active] 412965000395 peroxidatic and resolving cysteines [active] 412965000396 Rubredoxin [Energy production and conversion]; Region: COG1773 412965000397 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 412965000398 iron binding site [ion binding]; other site 412965000399 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 412965000400 tartrate dehydrogenase; Region: TTC; TIGR02089 412965000401 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 412965000402 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 412965000403 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 412965000404 dimer interface [polypeptide binding]; other site 412965000405 ADP-ribose binding site [chemical binding]; other site 412965000406 active site 412965000407 nudix motif; other site 412965000408 metal binding site [ion binding]; metal-binding site 412965000409 diaminopimelate decarboxylase; Region: lysA; TIGR01048 412965000410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 412965000411 active site 412965000412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412965000413 substrate binding site [chemical binding]; other site 412965000414 catalytic residues [active] 412965000415 dimer interface [polypeptide binding]; other site 412965000416 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 412965000417 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 412965000418 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 412965000419 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 412965000420 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 412965000421 dimerization interface [polypeptide binding]; other site 412965000422 active site 412965000423 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 412965000424 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 412965000425 active site 412965000426 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 412965000427 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 412965000428 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412965000429 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 412965000430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412965000431 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412965000432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412965000433 DNA binding residues [nucleotide binding] 412965000434 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 412965000435 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 412965000436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412965000437 active site 412965000438 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 412965000439 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 412965000440 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 412965000441 catalytic site [active] 412965000442 putative active site [active] 412965000443 putative substrate binding site [chemical binding]; other site 412965000444 dimer interface [polypeptide binding]; other site 412965000445 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 412965000446 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412965000447 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412965000448 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 412965000449 proline aminopeptidase P II; Provisional; Region: PRK10879 412965000450 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 412965000451 active site 412965000452 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 412965000453 RNA methyltransferase, RsmE family; Region: TIGR00046 412965000454 pyrroline-5-carboxylate reductase; Region: PLN02688 412965000455 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 412965000456 phosphoglycolate phosphatase; Provisional; Region: PRK13222 412965000457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965000458 motif II; other site 412965000459 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412965000460 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 412965000461 inhibitor-cofactor binding pocket; inhibition site 412965000462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000463 catalytic residue [active] 412965000464 primosome assembly protein PriA; Validated; Region: PRK05580 412965000465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412965000466 ATP binding site [chemical binding]; other site 412965000467 putative Mg++ binding site [ion binding]; other site 412965000468 helicase superfamily c-terminal domain; Region: HELICc; smart00490 412965000469 metal-binding heat shock protein; Provisional; Region: PRK00016 412965000470 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 412965000471 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 412965000472 Ligand Binding Site [chemical binding]; other site 412965000473 TilS substrate binding domain; Region: TilS; pfam09179 412965000474 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 412965000475 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 412965000476 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 412965000477 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 412965000478 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 412965000479 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 412965000480 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 412965000481 BolA-like protein; Region: BolA; pfam01722 412965000482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412965000483 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412965000484 ATP binding site [chemical binding]; other site 412965000485 Mg++ binding site [ion binding]; other site 412965000486 motif III; other site 412965000487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965000488 nucleotide binding region [chemical binding]; other site 412965000489 ATP-binding site [chemical binding]; other site 412965000490 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 412965000491 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 412965000492 active site 412965000493 HIGH motif; other site 412965000494 dimer interface [polypeptide binding]; other site 412965000495 KMSKS motif; other site 412965000496 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 412965000497 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 412965000498 putative catalytic cysteine [active] 412965000499 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 412965000500 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 412965000501 Lipopolysaccharide-assembly; Region: LptE; cl01125 412965000502 FtsH Extracellular; Region: FtsH_ext; pfam06480 412965000503 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 412965000504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000505 Walker A motif; other site 412965000506 ATP binding site [chemical binding]; other site 412965000507 Walker B motif; other site 412965000508 arginine finger; other site 412965000509 Peptidase family M41; Region: Peptidase_M41; pfam01434 412965000510 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 412965000511 dihydropteroate synthase; Region: DHPS; TIGR01496 412965000512 substrate binding pocket [chemical binding]; other site 412965000513 dimer interface [polypeptide binding]; other site 412965000514 inhibitor binding site; inhibition site 412965000515 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 412965000516 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 412965000517 active site 412965000518 substrate binding site [chemical binding]; other site 412965000519 metal binding site [ion binding]; metal-binding site 412965000520 electron transport complex protein RsxA; Provisional; Region: PRK05151 412965000521 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 412965000522 Putative Fe-S cluster; Region: FeS; pfam04060 412965000523 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 412965000524 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 412965000525 SLBB domain; Region: SLBB; pfam10531 412965000526 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412965000527 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 412965000528 FMN-binding domain; Region: FMN_bind; cl01081 412965000529 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 412965000530 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 412965000531 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 412965000532 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 412965000533 CoA binding domain; Region: CoA_binding; smart00881 412965000534 CoA-ligase; Region: Ligase_CoA; pfam00549 412965000535 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 412965000536 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 412965000537 CoA-ligase; Region: Ligase_CoA; pfam00549 412965000538 elongation factor P; Validated; Region: PRK00529 412965000539 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 412965000540 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 412965000541 RNA binding site [nucleotide binding]; other site 412965000542 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 412965000543 RNA binding site [nucleotide binding]; other site 412965000544 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 412965000545 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412965000546 dimer interface [polypeptide binding]; other site 412965000547 motif 1; other site 412965000548 active site 412965000549 motif 2; other site 412965000550 motif 3; other site 412965000551 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412965000552 Sel1-like repeats; Region: SEL1; smart00671 412965000553 Sel1-like repeats; Region: SEL1; smart00671 412965000554 Sel1-like repeats; Region: SEL1; smart00671 412965000555 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412965000556 Sel1-like repeats; Region: SEL1; smart00671 412965000557 argininosuccinate synthase; Provisional; Region: PRK13820 412965000558 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 412965000559 ANP binding site [chemical binding]; other site 412965000560 Substrate Binding Site II [chemical binding]; other site 412965000561 Substrate Binding Site I [chemical binding]; other site 412965000562 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 412965000563 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412965000564 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 412965000565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965000566 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412965000567 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 412965000568 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412965000569 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965000570 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412965000571 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 412965000572 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 412965000573 active site 412965000574 metal binding site [ion binding]; metal-binding site 412965000575 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412965000576 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 412965000577 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 412965000578 putative active site [active] 412965000579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 412965000580 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 412965000581 S17 interaction site [polypeptide binding]; other site 412965000582 S8 interaction site; other site 412965000583 16S rRNA interaction site [nucleotide binding]; other site 412965000584 streptomycin interaction site [chemical binding]; other site 412965000585 23S rRNA interaction site [nucleotide binding]; other site 412965000586 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 412965000587 30S ribosomal protein S7; Validated; Region: PRK05302 412965000588 elongation factor G; Reviewed; Region: PRK00007 412965000589 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 412965000590 G1 box; other site 412965000591 putative GEF interaction site [polypeptide binding]; other site 412965000592 GTP/Mg2+ binding site [chemical binding]; other site 412965000593 Switch I region; other site 412965000594 G2 box; other site 412965000595 G3 box; other site 412965000596 Switch II region; other site 412965000597 G4 box; other site 412965000598 G5 box; other site 412965000599 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 412965000600 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 412965000601 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 412965000602 elongation factor Tu; Reviewed; Region: PRK00049 412965000603 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412965000604 G1 box; other site 412965000605 GEF interaction site [polypeptide binding]; other site 412965000606 GTP/Mg2+ binding site [chemical binding]; other site 412965000607 Switch I region; other site 412965000608 G2 box; other site 412965000609 G3 box; other site 412965000610 Switch II region; other site 412965000611 G4 box; other site 412965000612 G5 box; other site 412965000613 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412965000614 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412965000615 Antibiotic Binding Site [chemical binding]; other site 412965000616 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 412965000617 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 412965000618 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 412965000619 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 412965000620 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 412965000621 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 412965000622 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 412965000623 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 412965000624 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 412965000625 putative translocon binding site; other site 412965000626 protein-rRNA interface [nucleotide binding]; other site 412965000627 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 412965000628 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 412965000629 G-X-X-G motif; other site 412965000630 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 412965000631 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 412965000632 23S rRNA interface [nucleotide binding]; other site 412965000633 5S rRNA interface [nucleotide binding]; other site 412965000634 putative antibiotic binding site [chemical binding]; other site 412965000635 L25 interface [polypeptide binding]; other site 412965000636 L27 interface [polypeptide binding]; other site 412965000637 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 412965000638 23S rRNA interface [nucleotide binding]; other site 412965000639 putative translocon interaction site; other site 412965000640 signal recognition particle (SRP54) interaction site; other site 412965000641 L23 interface [polypeptide binding]; other site 412965000642 trigger factor interaction site; other site 412965000643 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 412965000644 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 412965000645 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 412965000646 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 412965000647 RNA binding site [nucleotide binding]; other site 412965000648 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 412965000649 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 412965000650 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 412965000651 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 412965000652 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 412965000653 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 412965000654 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412965000655 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 412965000656 5S rRNA interface [nucleotide binding]; other site 412965000657 23S rRNA interface [nucleotide binding]; other site 412965000658 L5 interface [polypeptide binding]; other site 412965000659 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 412965000660 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 412965000661 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 412965000662 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 412965000663 23S rRNA binding site [nucleotide binding]; other site 412965000664 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 412965000665 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 412965000666 SecY translocase; Region: SecY; pfam00344 412965000667 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 412965000668 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 412965000669 30S ribosomal protein S13; Region: bact_S13; TIGR03631 412965000670 30S ribosomal protein S11; Validated; Region: PRK05309 412965000671 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 412965000672 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 412965000673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412965000674 RNA binding surface [nucleotide binding]; other site 412965000675 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 412965000676 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 412965000677 alphaNTD homodimer interface [polypeptide binding]; other site 412965000678 alphaNTD - beta interaction site [polypeptide binding]; other site 412965000679 alphaNTD - beta' interaction site [polypeptide binding]; other site 412965000680 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 412965000681 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 412965000682 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 412965000683 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298 412965000684 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412965000685 active site 412965000686 NTP binding site [chemical binding]; other site 412965000687 metal binding triad [ion binding]; metal-binding site 412965000688 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412965000689 probable DNA repair protein; Region: TIGR03623 412965000690 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 412965000691 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 412965000692 G1 box; other site 412965000693 GTP/Mg2+ binding site [chemical binding]; other site 412965000694 Switch I region; other site 412965000695 G2 box; other site 412965000696 G3 box; other site 412965000697 Switch II region; other site 412965000698 G4 box; other site 412965000699 G5 box; other site 412965000700 Cytochrome c; Region: Cytochrom_C; cl11414 412965000701 Cytochrome c553 [Energy production and conversion]; Region: COG2863 412965000702 Cytochrome c; Region: Cytochrom_C; cl11414 412965000703 trigger factor; Provisional; Region: tig; PRK01490 412965000704 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412965000705 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 412965000706 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 412965000707 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412965000708 oligomer interface [polypeptide binding]; other site 412965000709 active site residues [active] 412965000710 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 412965000711 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 412965000712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000713 Walker A motif; other site 412965000714 ATP binding site [chemical binding]; other site 412965000715 Walker B motif; other site 412965000716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412965000717 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 412965000718 Found in ATP-dependent protease La (LON); Region: LON; smart00464 412965000719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000720 Walker A motif; other site 412965000721 ATP binding site [chemical binding]; other site 412965000722 Walker B motif; other site 412965000723 arginine finger; other site 412965000724 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412965000725 DsrE/DsrF-like family; Region: DrsE; pfam02635 412965000726 multifunctional aminopeptidase A; Provisional; Region: PRK00913 412965000727 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 412965000728 interface (dimer of trimers) [polypeptide binding]; other site 412965000729 Substrate-binding/catalytic site; other site 412965000730 Zn-binding sites [ion binding]; other site 412965000731 Domain of unknown function DUF302; Region: DUF302; pfam03625 412965000732 FOG: CBS domain [General function prediction only]; Region: COG0517 412965000733 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 412965000734 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412965000735 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 412965000736 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 412965000737 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412965000738 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 412965000739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000740 catalytic residue [active] 412965000741 thymidylate kinase; Validated; Region: tmk; PRK00698 412965000742 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 412965000743 TMP-binding site; other site 412965000744 ATP-binding site [chemical binding]; other site 412965000745 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 412965000746 DNA polymerase III subunit delta'; Validated; Region: PRK08485 412965000747 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 412965000748 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 412965000749 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412965000750 inhibitor-cofactor binding pocket; inhibition site 412965000751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000752 catalytic residue [active] 412965000753 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 412965000754 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 412965000755 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 412965000756 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412965000757 CPxP motif; other site 412965000758 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 412965000759 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412965000760 active site 412965000761 dimer interface [polypeptide binding]; other site 412965000762 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 412965000763 active site 412965000764 dimerization interface [polypeptide binding]; other site 412965000765 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 412965000766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965000767 FeS/SAM binding site; other site 412965000768 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 412965000769 feedback inhibition sensing region; other site 412965000770 homohexameric interface [polypeptide binding]; other site 412965000771 nucleotide binding site [chemical binding]; other site 412965000772 N-acetyl-L-glutamate binding site [chemical binding]; other site 412965000773 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 412965000774 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 412965000775 FAD binding pocket [chemical binding]; other site 412965000776 FAD binding motif [chemical binding]; other site 412965000777 phosphate binding motif [ion binding]; other site 412965000778 beta-alpha-beta structure motif; other site 412965000779 NAD binding pocket [chemical binding]; other site 412965000780 Iron coordination center [ion binding]; other site 412965000781 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 412965000782 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412965000783 catalytic residue [active] 412965000784 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 412965000785 active site 412965000786 Protein of unknown function; Region: DUF3971; pfam13116 412965000787 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 412965000788 protease TldD; Provisional; Region: tldD; PRK10735 412965000789 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 412965000790 NADH dehydrogenase subunit B; Validated; Region: PRK06411 412965000791 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 412965000792 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 412965000793 NADH dehydrogenase subunit D; Validated; Region: PRK06075 412965000794 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 412965000795 NADH dehydrogenase subunit E; Validated; Region: PRK07539 412965000796 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 412965000797 putative dimer interface [polypeptide binding]; other site 412965000798 [2Fe-2S] cluster binding site [ion binding]; other site 412965000799 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 412965000800 SLBB domain; Region: SLBB; pfam10531 412965000801 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 412965000802 NADH dehydrogenase subunit G; Validated; Region: PRK09129 412965000803 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 412965000804 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 412965000805 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965000806 molybdopterin cofactor binding site; other site 412965000807 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 412965000808 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 412965000809 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 412965000810 4Fe-4S binding domain; Region: Fer4; pfam00037 412965000811 4Fe-4S binding domain; Region: Fer4; pfam00037 412965000812 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 412965000813 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 412965000814 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 412965000815 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 412965000816 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412965000817 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 412965000818 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412965000819 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 412965000820 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 412965000821 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 412965000822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965000823 S-adenosylmethionine binding site [chemical binding]; other site 412965000824 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 412965000825 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412965000826 intersubunit interface [polypeptide binding]; other site 412965000827 ribosome recycling factor; Reviewed; Region: frr; PRK00083 412965000828 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 412965000829 hinge region; other site 412965000830 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 412965000831 putative nucleotide binding site [chemical binding]; other site 412965000832 uridine monophosphate binding site [chemical binding]; other site 412965000833 homohexameric interface [polypeptide binding]; other site 412965000834 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 412965000835 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412965000836 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412965000837 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 412965000838 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 412965000839 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 412965000840 active site 412965000841 substrate binding site [chemical binding]; other site 412965000842 cosubstrate binding site; other site 412965000843 catalytic site [active] 412965000844 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 412965000845 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 412965000846 dimerization interface [polypeptide binding]; other site 412965000847 putative ATP binding site [chemical binding]; other site 412965000848 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 412965000849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412965000850 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 412965000851 Walker A motif; other site 412965000852 ATP binding site [chemical binding]; other site 412965000853 Walker B motif; other site 412965000854 arginine finger; other site 412965000855 siroheme synthase; Provisional; Region: cysG; PRK10637 412965000856 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 412965000857 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 412965000858 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 412965000859 active site 412965000860 SAM binding site [chemical binding]; other site 412965000861 homodimer interface [polypeptide binding]; other site 412965000862 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 412965000863 phosphoserine phosphatase SerB; Region: serB; TIGR00338 412965000864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965000865 motif II; other site 412965000866 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 412965000867 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 412965000868 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 412965000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412965000870 binding surface 412965000871 TPR motif; other site 412965000872 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 412965000873 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 412965000874 metal binding site [ion binding]; metal-binding site 412965000875 dimer interface [polypeptide binding]; other site 412965000876 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 412965000877 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 412965000878 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412965000879 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 412965000880 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 412965000881 dihydrodipicolinate synthase; Region: dapA; TIGR00674 412965000882 dimer interface [polypeptide binding]; other site 412965000883 active site 412965000884 catalytic residue [active] 412965000885 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 412965000886 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 412965000887 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 412965000888 nucleotide binding pocket [chemical binding]; other site 412965000889 K-X-D-G motif; other site 412965000890 catalytic site [active] 412965000891 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 412965000892 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 412965000893 Dimer interface [polypeptide binding]; other site 412965000894 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 412965000895 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412965000896 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 412965000897 FOG: CBS domain [General function prediction only]; Region: COG0517 412965000898 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 412965000899 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 412965000900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000901 ANTAR domain; Region: ANTAR; pfam03861 412965000902 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 412965000903 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 412965000904 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 412965000905 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 412965000906 metal binding site [ion binding]; metal-binding site 412965000907 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 412965000908 glutathione reductase; Validated; Region: PRK06116 412965000909 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 412965000910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412965000911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965000912 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412965000913 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 412965000914 dimer interface [polypeptide binding]; other site 412965000915 putative metal binding site [ion binding]; other site 412965000916 peptide chain release factor 2; Validated; Region: prfB; PRK00578 412965000917 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412965000918 RF-1 domain; Region: RF-1; pfam00472 412965000919 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 412965000920 16S/18S rRNA binding site [nucleotide binding]; other site 412965000921 S13e-L30e interaction site [polypeptide binding]; other site 412965000922 25S rRNA binding site [nucleotide binding]; other site 412965000923 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 412965000924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 412965000925 putative acyl-acceptor binding pocket; other site 412965000926 DNA primase, catalytic core; Region: dnaG; TIGR01391 412965000927 CHC2 zinc finger; Region: zf-CHC2; pfam01807 412965000928 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 412965000929 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 412965000930 active site 412965000931 metal binding site [ion binding]; metal-binding site 412965000932 interdomain interaction site; other site 412965000933 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 412965000934 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 412965000935 MraW methylase family; Region: Methyltransf_5; cl17771 412965000936 mraZ protein; Region: TIGR00242 412965000937 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 412965000938 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412965000939 CAP-like domain; other site 412965000940 active site 412965000941 primary dimer interface [polypeptide binding]; other site 412965000942 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 412965000943 active site 412965000944 putative GTP cyclohydrolase; Provisional; Region: PRK13674 412965000945 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 412965000946 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412965000947 DNA gyrase subunit A; Validated; Region: PRK05560 412965000948 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412965000949 CAP-like domain; other site 412965000950 active site 412965000951 primary dimer interface [polypeptide binding]; other site 412965000952 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000953 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000954 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000955 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000956 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000957 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000958 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 412965000959 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 412965000960 G1 box; other site 412965000961 putative GEF interaction site [polypeptide binding]; other site 412965000962 GTP/Mg2+ binding site [chemical binding]; other site 412965000963 Switch I region; other site 412965000964 G2 box; other site 412965000965 G3 box; other site 412965000966 Switch II region; other site 412965000967 G4 box; other site 412965000968 G5 box; other site 412965000969 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 412965000970 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 412965000971 catalytic motif [active] 412965000972 Zn binding site [ion binding]; other site 412965000973 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 412965000974 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 412965000975 Mg++ binding site [ion binding]; other site 412965000976 putative catalytic motif [active] 412965000977 putative substrate binding site [chemical binding]; other site 412965000978 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 412965000979 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 412965000980 homodimer interface [polypeptide binding]; other site 412965000981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000982 catalytic residue [active] 412965000983 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 412965000984 FAD binding domain; Region: FAD_binding_4; pfam01565 412965000985 FAD binding domain; Region: FAD_binding_4; pfam01565 412965000986 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 412965000987 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412965000988 Cysteine-rich domain; Region: CCG; pfam02754 412965000989 Cysteine-rich domain; Region: CCG; pfam02754 412965000990 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 412965000991 TRAM domain; Region: TRAM; cl01282 412965000992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965000993 S-adenosylmethionine binding site [chemical binding]; other site 412965000994 Probable gene remnant. Similar to the central region of beta-hexosaminidase (342 aa) in Shewanella sp. MR-7. 412965000995 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 412965000996 Part of AAA domain; Region: AAA_19; pfam13245 412965000997 Family description; Region: UvrD_C_2; pfam13538 412965000998 Radical SAM superfamily; Region: Radical_SAM; pfam04055 412965000999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001000 FeS/SAM binding site; other site 412965001001 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412965001002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412965001003 catalytic residues [active] 412965001004 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 412965001005 ArsC family; Region: ArsC; pfam03960 412965001006 catalytic residues [active] 412965001007 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412965001008 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 412965001009 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 412965001010 N-terminal domain interface [polypeptide binding]; other site 412965001011 dimer interface [polypeptide binding]; other site 412965001012 substrate binding pocket (H-site) [chemical binding]; other site 412965001013 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 412965001014 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 412965001015 active site 412965001016 (T/H)XGH motif; other site 412965001017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 412965001018 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 412965001019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 412965001020 RNA binding surface [nucleotide binding]; other site 412965001021 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412965001022 active site 412965001023 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 412965001024 Catalytic site [active] 412965001025 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 412965001026 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 412965001027 DNA binding site [nucleotide binding] 412965001028 catalytic residue [active] 412965001029 H2TH interface [polypeptide binding]; other site 412965001030 putative catalytic residues [active] 412965001031 turnover-facilitating residue; other site 412965001032 intercalation triad [nucleotide binding]; other site 412965001033 8OG recognition residue [nucleotide binding]; other site 412965001034 putative reading head residues; other site 412965001035 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 412965001036 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412965001037 Protein of unknown function (DUF989); Region: DUF989; pfam06181 412965001038 Protein of unknown function (DUF989); Region: DUF989; pfam06181 412965001039 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 412965001040 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 412965001041 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412965001042 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 412965001043 Type III pantothenate kinase; Region: Pan_kinase; cl17198 412965001044 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 412965001045 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 412965001046 active site 412965001047 HIGH motif; other site 412965001048 dimer interface [polypeptide binding]; other site 412965001049 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965001050 active site 412965001051 KMSKS motif; other site 412965001052 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412965001053 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412965001054 RNA binding surface [nucleotide binding]; other site 412965001055 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 412965001056 probable active site [active] 412965001057 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 412965001058 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965001059 active site 412965001060 HIGH motif; other site 412965001061 nucleotide binding site [chemical binding]; other site 412965001062 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412965001063 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412965001064 active site 412965001065 KMSKS motif; other site 412965001066 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 412965001067 tRNA binding surface [nucleotide binding]; other site 412965001068 anticodon binding site; other site 412965001069 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412965001070 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 412965001071 active site 412965001072 dimer interface [polypeptide binding]; other site 412965001073 metal binding site [ion binding]; metal-binding site 412965001074 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 412965001075 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 412965001076 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 412965001077 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 412965001078 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 412965001079 GatB domain; Region: GatB_Yqey; smart00845 412965001080 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 412965001081 Peptidase family M50; Region: Peptidase_M50; pfam02163 412965001082 active site 412965001083 putative substrate binding region [chemical binding]; other site 412965001084 prolyl-tRNA synthetase; Provisional; Region: PRK09194 412965001085 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 412965001086 dimer interface [polypeptide binding]; other site 412965001087 motif 1; other site 412965001088 active site 412965001089 motif 2; other site 412965001090 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 412965001091 putative deacylase active site [active] 412965001092 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412965001093 active site 412965001094 motif 3; other site 412965001095 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 412965001096 anticodon binding site; other site 412965001097 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 412965001098 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 412965001099 Domain of unknown function DUF21; Region: DUF21; pfam01595 412965001100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412965001101 Transporter associated domain; Region: CorC_HlyC; smart01091 412965001102 enolase; Provisional; Region: eno; PRK00077 412965001103 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 412965001104 dimer interface [polypeptide binding]; other site 412965001105 metal binding site [ion binding]; metal-binding site 412965001106 substrate binding pocket [chemical binding]; other site 412965001107 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 412965001108 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412965001109 Protein export membrane protein; Region: SecD_SecF; cl14618 412965001110 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 412965001111 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 412965001112 G1 box; other site 412965001113 putative GEF interaction site [polypeptide binding]; other site 412965001114 GTP/Mg2+ binding site [chemical binding]; other site 412965001115 Switch I region; other site 412965001116 G2 box; other site 412965001117 G3 box; other site 412965001118 Switch II region; other site 412965001119 G4 box; other site 412965001120 G5 box; other site 412965001121 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 412965001122 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 412965001123 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 412965001124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001125 S-adenosylmethionine binding site [chemical binding]; other site 412965001126 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412965001127 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412965001128 substrate binding pocket [chemical binding]; other site 412965001129 chain length determination region; other site 412965001130 substrate-Mg2+ binding site; other site 412965001131 catalytic residues [active] 412965001132 aspartate-rich region 1; other site 412965001133 active site lid residues [active] 412965001134 aspartate-rich region 2; other site 412965001135 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 412965001136 DEAD_2; Region: DEAD_2; pfam06733 412965001137 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 412965001138 Cation transport protein; Region: TrkH; cl17365 412965001139 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 412965001140 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 412965001141 TrkA-N domain; Region: TrkA_N; pfam02254 412965001142 TrkA-C domain; Region: TrkA_C; pfam02080 412965001143 TrkA-N domain; Region: TrkA_N; pfam02254 412965001144 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 412965001145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412965001146 active site 412965001147 phosphorylation site [posttranslational modification] 412965001148 intermolecular recognition site; other site 412965001149 dimerization interface [polypeptide binding]; other site 412965001150 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 412965001151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 412965001152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412965001153 dimerization interface [polypeptide binding]; other site 412965001154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412965001155 dimer interface [polypeptide binding]; other site 412965001156 phosphorylation site [posttranslational modification] 412965001157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965001158 ATP binding site [chemical binding]; other site 412965001159 Mg2+ binding site [ion binding]; other site 412965001160 G-X-G motif; other site 412965001161 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 412965001162 dimer interface [polypeptide binding]; other site 412965001163 substrate binding site [chemical binding]; other site 412965001164 metal binding sites [ion binding]; metal-binding site 412965001165 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 412965001166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001167 S-adenosylmethionine binding site [chemical binding]; other site 412965001168 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 412965001169 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 412965001170 active site 412965001171 (T/H)XGH motif; other site 412965001172 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 412965001173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412965001174 nucleotide binding site [chemical binding]; other site 412965001175 chaperone protein DnaJ; Provisional; Region: PRK10767 412965001176 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412965001177 HSP70 interaction site [polypeptide binding]; other site 412965001178 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 412965001179 substrate binding site [polypeptide binding]; other site 412965001180 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 412965001181 Zn binding sites [ion binding]; other site 412965001182 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 412965001183 dimer interface [polypeptide binding]; other site 412965001184 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 412965001185 RuvA N terminal domain; Region: RuvA_N; pfam01330 412965001186 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 412965001187 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 412965001188 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 412965001189 substrate binding site [chemical binding]; other site 412965001190 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 412965001191 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 412965001192 substrate binding site [chemical binding]; other site 412965001193 ligand binding site [chemical binding]; other site 412965001194 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 412965001195 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412965001196 active site 412965001197 dimer interface [polypeptide binding]; other site 412965001198 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412965001199 Ligand Binding Site [chemical binding]; other site 412965001200 Molecular Tunnel; other site 412965001201 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 412965001202 RNA/DNA hybrid binding site [nucleotide binding]; other site 412965001203 active site 412965001204 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 412965001205 putative coenzyme Q binding site [chemical binding]; other site 412965001206 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 412965001207 SmpB-tmRNA interface; other site 412965001208 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 412965001209 active site 412965001210 multimer interface [polypeptide binding]; other site 412965001211 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 412965001212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001213 FeS/SAM binding site; other site 412965001214 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 412965001215 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412965001216 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412965001217 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 412965001218 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 412965001219 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 412965001220 TPP-binding site; other site 412965001221 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412965001222 PYR/PP interface [polypeptide binding]; other site 412965001223 dimer interface [polypeptide binding]; other site 412965001224 TPP binding site [chemical binding]; other site 412965001225 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412965001226 putative protease; Provisional; Region: PRK15452 412965001227 Peptidase family U32; Region: Peptidase_U32; pfam01136 412965001228 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 412965001229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001230 S-adenosylmethionine binding site [chemical binding]; other site 412965001231 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 412965001232 putative GSH binding site [chemical binding]; other site 412965001233 catalytic residues [active] 412965001234 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 412965001235 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 412965001236 dimerization interface [polypeptide binding]; other site 412965001237 ATP binding site [chemical binding]; other site 412965001238 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 412965001239 dimerization interface [polypeptide binding]; other site 412965001240 ATP binding site [chemical binding]; other site 412965001241 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 412965001242 putative active site [active] 412965001243 catalytic triad [active] 412965001244 hypothetical protein; Validated; Region: PRK00110 412965001245 quinolinate synthetase; Provisional; Region: PRK09375 412965001246 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 412965001247 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 412965001248 dimer interface [polypeptide binding]; other site 412965001249 anticodon binding site; other site 412965001250 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 412965001251 homodimer interface [polypeptide binding]; other site 412965001252 motif 1; other site 412965001253 active site 412965001254 motif 2; other site 412965001255 GAD domain; Region: GAD; pfam02938 412965001256 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412965001257 active site 412965001258 motif 3; other site 412965001259 Uncharacterized conserved protein [Function unknown]; Region: COG2928 412965001260 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412965001261 active site 412965001262 Peptidase family M48; Region: Peptidase_M48; cl12018 412965001263 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 412965001264 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 412965001265 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 412965001266 active site 412965001267 catalytic site [active] 412965001268 substrate binding site [chemical binding]; other site 412965001269 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 412965001270 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 412965001271 dimer interface [polypeptide binding]; other site 412965001272 allosteric magnesium binding site [ion binding]; other site 412965001273 active site 412965001274 aspartate-rich active site metal binding site; other site 412965001275 Schiff base residues; other site 412965001276 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 412965001277 ThiC-associated domain; Region: ThiC-associated; pfam13667 412965001278 ThiC family; Region: ThiC; pfam01964 412965001279 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 412965001280 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 412965001281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412965001282 GTPase CgtA; Reviewed; Region: obgE; PRK12299 412965001283 GTP1/OBG; Region: GTP1_OBG; pfam01018 412965001284 Obg GTPase; Region: Obg; cd01898 412965001285 G1 box; other site 412965001286 GTP/Mg2+ binding site [chemical binding]; other site 412965001287 Switch I region; other site 412965001288 G2 box; other site 412965001289 G3 box; other site 412965001290 Switch II region; other site 412965001291 G4 box; other site 412965001292 G5 box; other site 412965001293 gamma-glutamyl kinase; Provisional; Region: PRK05429 412965001294 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 412965001295 nucleotide binding site [chemical binding]; other site 412965001296 homotetrameric interface [polypeptide binding]; other site 412965001297 putative phosphate binding site [ion binding]; other site 412965001298 putative allosteric binding site; other site 412965001299 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 412965001300 catalytic center binding site [active] 412965001301 ATP binding site [chemical binding]; other site 412965001302 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 412965001303 oligomerization interface [polypeptide binding]; other site 412965001304 active site 412965001305 metal binding site [ion binding]; metal-binding site 412965001306 pantoate--beta-alanine ligase; Region: panC; TIGR00018 412965001307 Pantoate-beta-alanine ligase; Region: PanC; cd00560 412965001308 active site 412965001309 ATP-binding site [chemical binding]; other site 412965001310 pantoate-binding site; other site 412965001311 HXXH motif; other site 412965001312 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965001313 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 412965001314 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 412965001315 thiamine monophosphate kinase; Provisional; Region: PRK05731 412965001316 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 412965001317 ATP binding site [chemical binding]; other site 412965001318 dimerization interface [polypeptide binding]; other site 412965001319 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 412965001320 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 412965001321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965001322 motif II; other site 412965001323 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 412965001324 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412965001325 tetramer interface [polypeptide binding]; other site 412965001326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001327 catalytic residue [active] 412965001328 isocitrate dehydrogenase; Validated; Region: PRK07362 412965001329 isocitrate dehydrogenase; Reviewed; Region: PRK07006 412965001330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 412965001331 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 412965001332 aspartate aminotransferase; Provisional; Region: PRK05764 412965001333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412965001334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001335 homodimer interface [polypeptide binding]; other site 412965001336 catalytic residue [active] 412965001337 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 412965001338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001339 FeS/SAM binding site; other site 412965001340 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412965001341 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 412965001342 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 412965001343 Tetramer interface [polypeptide binding]; other site 412965001344 active site 412965001345 FMN-binding site [chemical binding]; other site 412965001346 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 412965001347 active site 412965001348 dimer interface [polypeptide binding]; other site 412965001349 hypothetical protein; Provisional; Region: PRK09126 412965001350 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412965001351 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 412965001352 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 412965001353 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 412965001354 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 412965001355 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 412965001356 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 412965001357 shikimate binding site; other site 412965001358 NAD(P) binding site [chemical binding]; other site 412965001359 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 412965001360 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 412965001361 homodimer interface [polypeptide binding]; other site 412965001362 oligonucleotide binding site [chemical binding]; other site 412965001363 pteridine reductase; Provisional; Region: PRK09135 412965001364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001365 NAD(P) binding site [chemical binding]; other site 412965001366 active site 412965001367 Uncharacterized conserved protein [Function unknown]; Region: COG1565 412965001368 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 412965001369 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 412965001370 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 412965001371 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 412965001372 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412965001373 PYR/PP interface [polypeptide binding]; other site 412965001374 dimer interface [polypeptide binding]; other site 412965001375 TPP binding site [chemical binding]; other site 412965001376 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 412965001377 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 412965001378 TPP-binding site [chemical binding]; other site 412965001379 dimer interface [polypeptide binding]; other site 412965001380 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 412965001381 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 412965001382 putative valine binding site [chemical binding]; other site 412965001383 dimer interface [polypeptide binding]; other site 412965001384 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 412965001385 ketol-acid reductoisomerase; Provisional; Region: PRK05479 412965001386 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 412965001387 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 412965001388 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 412965001389 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 412965001390 2-isopropylmalate synthase; Validated; Region: PRK00915 412965001391 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 412965001392 active site 412965001393 catalytic residues [active] 412965001394 metal binding site [ion binding]; metal-binding site 412965001395 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 412965001396 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 412965001397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 412965001398 ornithine carbamoyltransferase; Provisional; Region: PRK00779 412965001399 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412965001400 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412965001401 acetylornithine aminotransferase; Provisional; Region: PRK02627 412965001402 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412965001403 inhibitor-cofactor binding pocket; inhibition site 412965001404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001405 catalytic residue [active] 412965001406 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 412965001407 30S subunit binding site; other site 412965001408 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 412965001409 MgtE intracellular N domain; Region: MgtE_N; smart00924 412965001410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 412965001411 Divalent cation transporter; Region: MgtE; cl00786 412965001412 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 412965001413 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 412965001414 active site 412965001415 substrate binding site [chemical binding]; other site 412965001416 metal binding site [ion binding]; metal-binding site 412965001417 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 412965001418 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 412965001419 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 412965001420 dimer interface [polypeptide binding]; other site 412965001421 TPP-binding site [chemical binding]; other site 412965001422 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 412965001423 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 412965001424 RNase E interface [polypeptide binding]; other site 412965001425 trimer interface [polypeptide binding]; other site 412965001426 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 412965001427 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 412965001428 RNase E interface [polypeptide binding]; other site 412965001429 trimer interface [polypeptide binding]; other site 412965001430 active site 412965001431 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 412965001432 putative nucleic acid binding region [nucleotide binding]; other site 412965001433 G-X-X-G motif; other site 412965001434 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 412965001435 RNA binding site [nucleotide binding]; other site 412965001436 domain interface; other site 412965001437 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 412965001438 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412965001439 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 412965001440 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 412965001441 active site 412965001442 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 412965001443 Bacterial SH3 domain; Region: SH3_3; cl17532 412965001444 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 412965001445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965001446 active site 412965001447 HIGH motif; other site 412965001448 nucleotide binding site [chemical binding]; other site 412965001449 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412965001450 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 412965001451 active site 412965001452 KMSKS motif; other site 412965001453 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 412965001454 tRNA binding surface [nucleotide binding]; other site 412965001455 anticodon binding site; other site 412965001456 hypothetical protein; Validated; Region: PRK00153 412965001457 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 412965001458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965001459 Walker A motif; other site 412965001460 ATP binding site [chemical binding]; other site 412965001461 Walker B motif; other site 412965001462 DNA polymerase III subunit delta'; Validated; Region: PRK08485 412965001463 arginine finger; other site 412965001464 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 412965001465 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412965001466 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412965001467 homodimer interface [polypeptide binding]; other site 412965001468 substrate-cofactor binding pocket; other site 412965001469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001470 catalytic residue [active] 412965001471 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412965001472 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412965001473 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 412965001474 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 412965001475 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 412965001476 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412965001477 Sel1 repeat; Region: Sel1; cl02723 412965001478 Sel1-like repeats; Region: SEL1; smart00671 412965001479 Sel1-like repeats; Region: SEL1; smart00671 412965001480 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 412965001481 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412965001482 HIGH motif; other site 412965001483 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412965001484 active site 412965001485 KMSKS motif; other site 412965001486 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 412965001487 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 412965001488 metal binding triad; other site 412965001489 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 412965001490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412965001491 Zn2+ binding site [ion binding]; other site 412965001492 Mg2+ binding site [ion binding]; other site 412965001493 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 412965001494 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 412965001495 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412965001496 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412965001497 catalytic residues [active] 412965001498 transcription termination factor Rho; Provisional; Region: rho; PRK09376 412965001499 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 412965001500 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 412965001501 RNA binding site [nucleotide binding]; other site 412965001502 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 412965001503 multimer interface [polypeptide binding]; other site 412965001504 Walker A motif; other site 412965001505 ATP binding site [chemical binding]; other site 412965001506 Walker B motif; other site 412965001507 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412965001508 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 412965001509 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 412965001510 poly(A) polymerase; Region: pcnB; TIGR01942 412965001511 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412965001512 active site 412965001513 NTP binding site [chemical binding]; other site 412965001514 metal binding triad [ion binding]; metal-binding site 412965001515 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412965001516 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 412965001517 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 412965001518 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412965001519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412965001520 substrate binding pocket [chemical binding]; other site 412965001521 chain length determination region; other site 412965001522 substrate-Mg2+ binding site; other site 412965001523 catalytic residues [active] 412965001524 aspartate-rich region 1; other site 412965001525 active site lid residues [active] 412965001526 aspartate-rich region 2; other site 412965001527 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 412965001528 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412965001529 dimer interface [polypeptide binding]; other site 412965001530 active site 412965001531 CoA binding pocket [chemical binding]; other site 412965001532 putative phosphate acyltransferase; Provisional; Region: PRK05331 412965001533 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 412965001534 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 412965001535 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412965001536 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412965001537 putative acyl-acceptor binding pocket; other site 412965001538 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 412965001539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001540 NAD(P) binding site [chemical binding]; other site 412965001541 active site 412965001542 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 412965001543 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 412965001544 active site 412965001545 dimerization interface [polypeptide binding]; other site 412965001546 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 412965001547 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412965001548 heat shock protein 90; Provisional; Region: PRK05218 412965001549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965001550 ATP binding site [chemical binding]; other site 412965001551 Mg2+ binding site [ion binding]; other site 412965001552 G-X-G motif; other site 412965001553 Phage maturation protein; Region: Phage_mat-A; cl17797 412965001554 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 412965001555 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 412965001556 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 412965001557 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412965001558 CPxP motif; other site 412965001559 glutamine synthetase; Provisional; Region: glnA; PRK09469 412965001560 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 412965001561 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 412965001562 biotin synthase; Region: bioB; TIGR00433 412965001563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001564 FeS/SAM binding site; other site 412965001565 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 412965001566 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 412965001567 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412965001568 active site 412965001569 homodimer interface [polypeptide binding]; other site 412965001570 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 412965001571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965001572 Walker A/P-loop; other site 412965001573 ATP binding site [chemical binding]; other site 412965001574 Q-loop/lid; other site 412965001575 ABC transporter signature motif; other site 412965001576 Walker B; other site 412965001577 D-loop; other site 412965001578 H-loop/switch region; other site 412965001579 ABC transporter; Region: ABC_tran_2; pfam12848 412965001580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412965001581 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 412965001582 Lumazine binding domain; Region: Lum_binding; pfam00677 412965001583 Lumazine binding domain; Region: Lum_binding; pfam00677 412965001584 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 412965001585 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 412965001586 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 412965001587 dimerization interface [polypeptide binding]; other site 412965001588 active site 412965001589 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 412965001590 homopentamer interface [polypeptide binding]; other site 412965001591 active site 412965001592 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 412965001593 putative RNA binding site [nucleotide binding]; other site 412965001594 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 412965001595 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 412965001596 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 412965001597 substrate binding pocket [chemical binding]; other site 412965001598 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 412965001599 B12 binding site [chemical binding]; other site 412965001600 cobalt ligand [ion binding]; other site 412965001601 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 412965001602 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 412965001603 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 412965001604 dimer interface [polypeptide binding]; other site 412965001605 ssDNA binding site [nucleotide binding]; other site 412965001606 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412965001607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965001608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412965001609 putative substrate translocation pore; other site 412965001610 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 412965001611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412965001612 binding surface 412965001613 TPR motif; other site 412965001614 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412965001615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412965001616 Zn2+ binding site [ion binding]; other site 412965001617 Mg2+ binding site [ion binding]; other site 412965001618 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412965001619 synthetase active site [active] 412965001620 NTP binding site [chemical binding]; other site 412965001621 metal binding site [ion binding]; metal-binding site 412965001622 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412965001623 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 412965001624 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 412965001625 translocation protein TolB; Provisional; Region: tolB; PRK04922 412965001626 TolB amino-terminal domain; Region: TolB_N; pfam04052 412965001627 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412965001628 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412965001629 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 412965001630 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412965001631 ligand binding site [chemical binding]; other site 412965001632 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 412965001633 hypothetical protein; Validated; Region: PRK09070 412965001634 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412965001635 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 412965001636 NAD synthetase; Provisional; Region: PRK13981 412965001637 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 412965001638 multimer interface [polypeptide binding]; other site 412965001639 active site 412965001640 catalytic triad [active] 412965001641 protein interface 1 [polypeptide binding]; other site 412965001642 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 412965001643 homodimer interface [polypeptide binding]; other site 412965001644 NAD binding pocket [chemical binding]; other site 412965001645 ATP binding pocket [chemical binding]; other site 412965001646 Mg binding site [ion binding]; other site 412965001647 active-site loop [active] 412965001648 Ferrochelatase; Region: Ferrochelatase; pfam00762 412965001649 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 412965001650 C-terminal domain interface [polypeptide binding]; other site 412965001651 active site 412965001652 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 412965001653 active site 412965001654 N-terminal domain interface [polypeptide binding]; other site 412965001655 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 412965001656 ATP cone domain; Region: ATP-cone; pfam03477 412965001657 Class I ribonucleotide reductase; Region: RNR_I; cd01679 412965001658 active site 412965001659 dimer interface [polypeptide binding]; other site 412965001660 catalytic residues [active] 412965001661 effector binding site; other site 412965001662 R2 peptide binding site; other site 412965001663 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 412965001664 dimer interface [polypeptide binding]; other site 412965001665 putative radical transfer pathway; other site 412965001666 diiron center [ion binding]; other site 412965001667 tyrosyl radical; other site 412965001668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412965001669 catalytic loop [active] 412965001670 iron binding site [ion binding]; other site 412965001671 dUTPase; Region: dUTPase_2; pfam08761 412965001672 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 412965001673 active site 412965001674 homodimer interface [polypeptide binding]; other site 412965001675 metal binding site [ion binding]; metal-binding site 412965001676 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 412965001677 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 412965001678 dimer interface [polypeptide binding]; other site 412965001679 catalytic site [active] 412965001680 putative active site [active] 412965001681 putative substrate binding site [chemical binding]; other site 412965001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 412965001683 Coenzyme A binding pocket [chemical binding]; other site 412965001684 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 412965001685 ribonuclease R; Region: RNase_R; TIGR02063 412965001686 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 412965001687 RNB domain; Region: RNB; pfam00773 412965001688 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 412965001689 RNA binding site [nucleotide binding]; other site 412965001690 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 412965001691 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 412965001692 GDP-binding site [chemical binding]; other site 412965001693 ACT binding site; other site 412965001694 IMP binding site; other site 412965001695 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 412965001696 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412965001697 dimer interface [polypeptide binding]; other site 412965001698 motif 1; other site 412965001699 active site 412965001700 motif 3; other site 412965001701 HflC protein; Region: hflC; TIGR01932 412965001702 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 412965001703 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 412965001704 HflK protein; Region: hflK; TIGR01933 412965001705 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 412965001706 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 412965001707 Organic solvent tolerance protein; Region: OstA_C; pfam04453 412965001708 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 412965001709 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 412965001710 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 412965001711 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412965001712 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 412965001713 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 412965001714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965001715 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412965001716 Walker A motif; other site 412965001717 ATP binding site [chemical binding]; other site 412965001718 Walker B motif; other site 412965001719 arginine finger; other site 412965001720 Protein of unknown function (DUF493); Region: DUF493; pfam04359 412965001721 lipoate-protein ligase B; Provisional; Region: PRK14342 412965001722 lipoyl synthase; Provisional; Region: PRK05481 412965001723 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412965001724 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412965001725 HlyD family secretion protein; Region: HlyD_3; pfam13437 412965001726 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 412965001727 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 412965001728 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 412965001729 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 412965001730 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 412965001731 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 412965001732 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 412965001733 active site 412965001734 metal binding site [ion binding]; metal-binding site 412965001735 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 412965001736 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412965001737 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 412965001738 zinc metallopeptidase RseP; Provisional; Region: PRK10779 412965001739 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 412965001740 active site 412965001741 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412965001742 protein binding site [polypeptide binding]; other site 412965001743 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412965001744 protein binding site [polypeptide binding]; other site 412965001745 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 412965001746 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 412965001747 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412965001748 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412965001749 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412965001750 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412965001751 Surface antigen; Region: Bac_surface_Ag; pfam01103 412965001752 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 412965001753 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 412965001754 putative trimer interface [polypeptide binding]; other site 412965001755 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 412965001756 putative CoA binding site [chemical binding]; other site 412965001757 trimer interface [polypeptide binding]; other site 412965001758 active site 412965001759 UDP-GlcNAc binding site [chemical binding]; other site 412965001760 lipid binding site [chemical binding]; lipid-binding site 412965001761 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 412965001762 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 412965001763 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 412965001764 active site 412965001765 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 412965001766 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 412965001767 oxidative damage protection protein; Provisional; Region: PRK05408 412965001768 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 412965001769 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 412965001770 catalytic site [active] 412965001771 G-X2-G-X-G-K; other site 412965001772 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 412965001773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412965001774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412965001775 DNA binding residues [nucleotide binding] 412965001776 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 412965001777 oligomerisation interface [polypeptide binding]; other site 412965001778 mobile loop; other site 412965001779 roof hairpin; other site 412965001780 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 412965001781 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 412965001782 ring oligomerisation interface [polypeptide binding]; other site 412965001783 ATP/Mg binding site [chemical binding]; other site 412965001784 stacking interactions; other site 412965001785 hinge regions; other site 412965001786 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 412965001787 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 412965001788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965001789 ATP binding site [chemical binding]; other site 412965001790 Mg2+ binding site [ion binding]; other site 412965001791 G-X-G motif; other site 412965001792 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412965001793 anchoring element; other site 412965001794 dimer interface [polypeptide binding]; other site 412965001795 ATP binding site [chemical binding]; other site 412965001796 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 412965001797 active site 412965001798 putative metal-binding site [ion binding]; other site 412965001799 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412965001800 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 412965001801 Ligand Binding Site [chemical binding]; other site 412965001802 acyl carrier protein; Provisional; Region: acpP; PRK00982 412965001803 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412965001804 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 412965001805 dimer interface [polypeptide binding]; other site 412965001806 active site 412965001807 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 412965001808 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 412965001809 active site 412965001810 Zn binding site [ion binding]; other site 412965001811 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 412965001812 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 412965001813 active site 412965001814 HIGH motif; other site 412965001815 KMSKS motif; other site 412965001816 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 412965001817 anticodon binding site; other site 412965001818 tRNA binding surface [nucleotide binding]; other site 412965001819 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 412965001820 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 412965001821 Walker A motif; other site 412965001822 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 412965001823 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412965001824 catalytic loop [active] 412965001825 iron binding site [ion binding]; other site 412965001826 chaperone protein HscA; Provisional; Region: hscA; PRK05183 412965001827 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 412965001828 nucleotide binding site [chemical binding]; other site 412965001829 putative NEF/HSP70 interaction site [polypeptide binding]; other site 412965001830 SBD interface [polypeptide binding]; other site 412965001831 co-chaperone HscB; Provisional; Region: hscB; PRK05014 412965001832 DnaJ domain; Region: DnaJ; pfam00226 412965001833 HSP70 interaction site [polypeptide binding]; other site 412965001834 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 412965001835 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965001836 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 412965001837 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 412965001838 trimerization site [polypeptide binding]; other site 412965001839 active site 412965001840 cysteine desulfurase; Provisional; Region: PRK14012 412965001841 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 412965001842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965001843 catalytic residue [active] 412965001844 Transcriptional regulator; Region: Rrf2; cl17282 412965001845 Rrf2 family protein; Region: rrf2_super; TIGR00738 412965001846 serine O-acetyltransferase; Region: cysE; TIGR01172 412965001847 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 412965001848 trimer interface [polypeptide binding]; other site 412965001849 active site 412965001850 substrate binding site [chemical binding]; other site 412965001851 CoA binding site [chemical binding]; other site 412965001852 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 412965001853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 412965001854 putative acyl-acceptor binding pocket; other site 412965001855 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 412965001856 Ligand Binding Site [chemical binding]; other site 412965001857 Outer membrane efflux protein; Region: OEP; pfam02321 412965001858 Outer membrane efflux protein; Region: OEP; pfam02321 412965001859 shikimate kinase; Reviewed; Region: aroK; PRK00131 412965001860 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 412965001861 ADP binding site [chemical binding]; other site 412965001862 magnesium binding site [ion binding]; other site 412965001863 putative shikimate binding site; other site 412965001864 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 412965001865 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 412965001866 homodimer interface [polypeptide binding]; other site 412965001867 substrate-cofactor binding pocket; other site 412965001868 catalytic residue [active] 412965001869 aspartate kinase; Reviewed; Region: PRK06635 412965001870 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 412965001871 putative nucleotide binding site [chemical binding]; other site 412965001872 putative catalytic residues [active] 412965001873 putative Mg ion binding site [ion binding]; other site 412965001874 putative aspartate binding site [chemical binding]; other site 412965001875 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 412965001876 putative allosteric regulatory site; other site 412965001877 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 412965001878 Peptidase family M48; Region: Peptidase_M48; pfam01435 412965001879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412965001880 RNA binding site [nucleotide binding]; other site 412965001881 GTPase RsgA; Reviewed; Region: PRK00098 412965001882 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 412965001883 GTPase/Zn-binding domain interface [polypeptide binding]; other site 412965001884 GTP/Mg2+ binding site [chemical binding]; other site 412965001885 G4 box; other site 412965001886 G5 box; other site 412965001887 G1 box; other site 412965001888 Switch I region; other site 412965001889 G2 box; other site 412965001890 G3 box; other site 412965001891 Switch II region; other site 412965001892 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 412965001893 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412965001894 IHF - DNA interface [nucleotide binding]; other site 412965001895 IHF dimer interface [polypeptide binding]; other site 412965001896 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 412965001897 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 412965001898 RNA binding site [nucleotide binding]; other site 412965001899 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 412965001900 RNA binding site [nucleotide binding]; other site 412965001901 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 412965001902 RNA binding site [nucleotide binding]; other site 412965001903 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412965001904 RNA binding site [nucleotide binding]; other site 412965001905 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412965001906 RNA binding site [nucleotide binding]; other site 412965001907 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 412965001908 RNA binding site [nucleotide binding]; other site 412965001909 cytidylate kinase; Provisional; Region: cmk; PRK00023 412965001910 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 412965001911 CMP-binding site; other site 412965001912 The sites determining sugar specificity; other site 412965001913 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 412965001914 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 412965001915 dimer interface [polypeptide binding]; other site 412965001916 putative anticodon binding site; other site 412965001917 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 412965001918 motif 1; other site 412965001919 active site 412965001920 motif 2; other site 412965001921 motif 3; other site 412965001922 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 412965001923 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412965001924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965001925 Walker A/P-loop; other site 412965001926 ATP binding site [chemical binding]; other site 412965001927 Q-loop/lid; other site 412965001928 ABC transporter signature motif; other site 412965001929 Walker B; other site 412965001930 D-loop; other site 412965001931 H-loop/switch region; other site 412965001932 ABC transporter; Region: ABC_tran_2; pfam12848 412965001933 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412965001934 hypothetical protein; Validated; Region: PRK08238 412965001935 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 412965001936 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412965001937 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 412965001938 hinge; other site 412965001939 active site 412965001940 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 412965001941 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 412965001942 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 412965001943 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 412965001944 NAD binding site [chemical binding]; other site 412965001945 dimerization interface [polypeptide binding]; other site 412965001946 product binding site; other site 412965001947 substrate binding site [chemical binding]; other site 412965001948 zinc binding site [ion binding]; other site 412965001949 catalytic residues [active] 412965001950 signal recognition particle protein; Provisional; Region: PRK10867 412965001951 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 412965001952 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412965001953 P loop; other site 412965001954 GTP binding site [chemical binding]; other site 412965001955 Signal peptide binding domain; Region: SRP_SPB; pfam02978 412965001956 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412965001957 GTP-binding protein LepA; Provisional; Region: PRK05433 412965001958 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 412965001959 G1 box; other site 412965001960 putative GEF interaction site [polypeptide binding]; other site 412965001961 GTP/Mg2+ binding site [chemical binding]; other site 412965001962 Switch I region; other site 412965001963 G2 box; other site 412965001964 G3 box; other site 412965001965 Switch II region; other site 412965001966 G4 box; other site 412965001967 G5 box; other site 412965001968 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 412965001969 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 412965001970 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 412965001971 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 412965001972 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 412965001973 catalytic triad [active] 412965001974 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 412965001975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001976 S-adenosylmethionine binding site [chemical binding]; other site 412965001977 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 412965001978 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 412965001979 active site 412965001980 hydrophilic channel; other site 412965001981 dimerization interface [polypeptide binding]; other site 412965001982 catalytic residues [active] 412965001983 active site lid [active] 412965001984 GTPase Era; Reviewed; Region: era; PRK00089 412965001985 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 412965001986 G1 box; other site 412965001987 GTP/Mg2+ binding site [chemical binding]; other site 412965001988 Switch I region; other site 412965001989 G2 box; other site 412965001990 Switch II region; other site 412965001991 G3 box; other site 412965001992 G4 box; other site 412965001993 G5 box; other site 412965001994 KH domain; Region: KH_2; pfam07650 412965001995 ribonuclease III; Reviewed; Region: rnc; PRK00102 412965001996 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 412965001997 dimerization interface [polypeptide binding]; other site 412965001998 active site 412965001999 metal binding site [ion binding]; metal-binding site 412965002000 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 412965002001 dsRNA binding site [nucleotide binding]; other site 412965002002 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09733 412965002003 thymidylate synthase; Reviewed; Region: thyA; PRK01827 412965002004 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 412965002005 dimerization interface [polypeptide binding]; other site 412965002006 active site 412965002007 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 412965002008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412965002009 dimerization interface [polypeptide binding]; other site 412965002010 putative DNA binding site [nucleotide binding]; other site 412965002011 putative Zn2+ binding site [ion binding]; other site 412965002012 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 412965002013 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 412965002014 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 412965002015 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 412965002016 protein binding site [polypeptide binding]; other site 412965002017 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 412965002018 Catalytic dyad [active] 412965002019 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412965002020 Catalytic site [active] 412965002021 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 412965002022 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412965002023 DsrC like protein; Region: DsrC; pfam04358 412965002024 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 412965002025 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 412965002026 hinge; other site 412965002027 active site 412965002028 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 412965002029 prephenate dehydrogenase; Validated; Region: PRK08507 412965002030 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 412965002031 Chorismate mutase type II; Region: CM_2; cl00693 412965002032 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 412965002033 Prephenate dehydratase; Region: PDT; pfam00800 412965002034 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 412965002035 putative L-Phe binding site [chemical binding]; other site 412965002036 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 412965002037 putative ligand binding site [chemical binding]; other site 412965002038 putative NAD binding site [chemical binding]; other site 412965002039 putative catalytic site [active] 412965002040 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 412965002041 L-serine binding site [chemical binding]; other site 412965002042 ACT domain interface; other site 412965002043 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 412965002044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965002045 catalytic residue [active] 412965002046 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 412965002047 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 412965002048 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 412965002049 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 412965002050 dimer interface [polypeptide binding]; other site 412965002051 active site 412965002052 glycine-pyridoxal phosphate binding site [chemical binding]; other site 412965002053 folate binding site [chemical binding]; other site 412965002054 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 412965002055 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412965002056 ATP binding site [chemical binding]; other site 412965002057 substrate interface [chemical binding]; other site 412965002058 methionine sulfoxide reductase A; Provisional; Region: PRK14054 412965002059 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412965002060 IHF dimer interface [polypeptide binding]; other site 412965002061 IHF - DNA interface [nucleotide binding]; other site 412965002062 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 412965002063 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 412965002064 putative tRNA-binding site [nucleotide binding]; other site 412965002065 B3/4 domain; Region: B3_4; pfam03483 412965002066 tRNA synthetase B5 domain; Region: B5; smart00874 412965002067 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 412965002068 dimer interface [polypeptide binding]; other site 412965002069 motif 1; other site 412965002070 motif 3; other site 412965002071 motif 2; other site 412965002072 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 412965002073 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 412965002074 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 412965002075 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 412965002076 dimer interface [polypeptide binding]; other site 412965002077 motif 1; other site 412965002078 active site 412965002079 motif 2; other site 412965002080 motif 3; other site 412965002081 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 412965002082 23S rRNA binding site [nucleotide binding]; other site 412965002083 L21 binding site [polypeptide binding]; other site 412965002084 L13 binding site [polypeptide binding]; other site 412965002085 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 412965002086 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 412965002087 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 412965002088 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 412965002089 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 412965002090 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 412965002091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412965002092 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 412965002093 active site 412965002094 dimer interface [polypeptide binding]; other site 412965002095 motif 1; other site 412965002096 motif 2; other site 412965002097 motif 3; other site 412965002098 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 412965002099 anticodon binding site; other site 412965002100 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 412965002101 DHH family; Region: DHH; pfam01368 412965002102 DHHA1 domain; Region: DHHA1; pfam02272 412965002103 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 412965002104 hydroxyglutarate oxidase; Provisional; Region: PRK11728 412965002105 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 412965002106 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 412965002107 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 412965002108 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 412965002109 NAD binding site [chemical binding]; other site 412965002110 homotetramer interface [polypeptide binding]; other site 412965002111 homodimer interface [polypeptide binding]; other site 412965002112 substrate binding site [chemical binding]; other site 412965002113 active site 412965002114 periplasmic folding chaperone; Provisional; Region: PRK10788 412965002115 SurA N-terminal domain; Region: SurA_N_3; cl07813 412965002116 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412965002117 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412965002118 IHF dimer interface [polypeptide binding]; other site 412965002119 IHF - DNA interface [nucleotide binding]; other site 412965002120 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 412965002121 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 412965002122 catalytic residues [active] 412965002123 central insert; other site 412965002124 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 412965002125 heme exporter protein CcmC; Region: ccmC; TIGR01191 412965002126 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 412965002127 Glycoprotease family; Region: Peptidase_M22; pfam00814 412965002128 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 412965002129 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 412965002130 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 412965002131 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 412965002132 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 412965002133 replicative DNA helicase; Region: DnaB; TIGR00665 412965002134 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 412965002135 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 412965002136 Walker A motif; other site 412965002137 ATP binding site [chemical binding]; other site 412965002138 Walker B motif; other site 412965002139 DNA binding loops [nucleotide binding] 412965002140 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 412965002141 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 412965002142 active site 412965002143 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412965002144 substrate binding site [chemical binding]; other site 412965002145 catalytic residues [active] 412965002146 dimer interface [polypeptide binding]; other site 412965002147 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 412965002148 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412965002149 active site 412965002150 metal binding site [ion binding]; metal-binding site 412965002151 hexamer interface [polypeptide binding]; other site 412965002152 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 412965002153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412965002154 TPR motif; other site 412965002155 TPR repeat; Region: TPR_11; pfam13414 412965002156 binding surface 412965002157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 412965002158 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 412965002159 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412965002160 dimer interface [polypeptide binding]; other site 412965002161 motif 1; other site 412965002162 active site 412965002163 motif 2; other site 412965002164 motif 3; other site 412965002165 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 412965002166 anticodon binding site; other site 412965002167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 412965002168 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 412965002169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412965002170 binding surface 412965002171 TPR motif; other site 412965002172 GTP-binding protein Der; Reviewed; Region: PRK00093 412965002173 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 412965002174 G1 box; other site 412965002175 GTP/Mg2+ binding site [chemical binding]; other site 412965002176 Switch I region; other site 412965002177 G2 box; other site 412965002178 Switch II region; other site 412965002179 G3 box; other site 412965002180 G4 box; other site 412965002181 G5 box; other site 412965002182 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 412965002183 G1 box; other site 412965002184 GTP/Mg2+ binding site [chemical binding]; other site 412965002185 Switch I region; other site 412965002186 G2 box; other site 412965002187 G3 box; other site 412965002188 Switch II region; other site 412965002189 G4 box; other site 412965002190 G5 box; other site 412965002191 CTP synthetase; Validated; Region: pyrG; PRK05380 412965002192 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 412965002193 Catalytic site [active] 412965002194 active site 412965002195 UTP binding site [chemical binding]; other site 412965002196 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 412965002197 active site 412965002198 putative oxyanion hole; other site 412965002199 catalytic triad [active] 412965002200 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 412965002201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412965002202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965002203 Walker A/P-loop; other site 412965002204 ATP binding site [chemical binding]; other site 412965002205 Q-loop/lid; other site 412965002206 ABC transporter signature motif; other site 412965002207 Walker B; other site 412965002208 D-loop; other site 412965002209 H-loop/switch region; other site 412965002210 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412965002211 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412965002212 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 412965002213 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412965002214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965002215 catalytic residue [active] 412965002216 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412965002217 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 412965002218 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412965002219 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 412965002220 iron-sulfur cluster [ion binding]; other site 412965002221 [2Fe-2S] cluster binding site [ion binding]; other site 412965002222 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412965002223 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412965002224 catalytic residue [active] 412965002225 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412965002226 DNA-binding site [nucleotide binding]; DNA binding site 412965002227 RNA-binding motif; other site 412965002228 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965002229 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412965002230 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 412965002231 ligand binding site [chemical binding]; other site 412965002232 active site 412965002233 UGI interface [polypeptide binding]; other site 412965002234 catalytic site [active] 412965002235 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 412965002236 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 412965002237 ligand binding site [chemical binding]; other site 412965002238 NAD binding site [chemical binding]; other site 412965002239 catalytic site [active] 412965002240 homodimer interface [polypeptide binding]; other site 412965002241 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 412965002242 active site 412965002243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 412965002244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 412965002245 active site 412965002246 ATP binding site [chemical binding]; other site 412965002247 substrate binding site [chemical binding]; other site 412965002248 activation loop (A-loop); other site 412965002249 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 412965002250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965002251 putative substrate translocation pore; other site 412965002252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965002253 putative substrate translocation pore; other site 412965002254 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 412965002255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965002256 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412965002257 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 412965002258 MoaE homodimer interface [polypeptide binding]; other site 412965002259 MoaD interaction [polypeptide binding]; other site 412965002260 active site residues [active] 412965002261 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 412965002262 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 412965002263 GTP binding site; other site 412965002264 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412965002265 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412965002266 dimer interface [polypeptide binding]; other site 412965002267 putative functional site; other site 412965002268 putative MPT binding site; other site 412965002269 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 412965002270 trimer interface [polypeptide binding]; other site 412965002271 dimer interface [polypeptide binding]; other site 412965002272 putative active site [active] 412965002273 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 412965002274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965002275 FeS/SAM binding site; other site 412965002276 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 412965002277 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 412965002278 MoaE interaction surface [polypeptide binding]; other site 412965002279 MoeB interaction surface [polypeptide binding]; other site 412965002280 thiocarboxylated glycine; other site 412965002281 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 412965002282 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 412965002283 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 412965002284 4Fe-4S binding domain; Region: Fer4_6; pfam12837 412965002285 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 412965002286 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 412965002287 [4Fe-4S] binding site [ion binding]; other site 412965002288 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965002289 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965002290 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965002291 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 412965002292 molybdopterin cofactor binding site; other site 412965002293 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 412965002294 MPT binding site; other site 412965002295 trimer interface [polypeptide binding]; other site 412965002296 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 412965002297 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 412965002298 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 412965002299 Walker A motif; other site 412965002300 ATP binding site [chemical binding]; other site 412965002301 Walker B motif; other site 412965002302 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 412965002303 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 412965002304 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 412965002305 dimer interface [polypeptide binding]; other site 412965002306 active site 412965002307 catalytic residue [active] 412965002308 metal binding site [ion binding]; metal-binding site 412965002309 Probable gene remnant. Similar to the N-terminal region of Rubisco operon transcriptional regulator TR:Q6SEU6 (292 aa). 412965002310 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 412965002311 heterotetramer interface [polypeptide binding]; other site 412965002312 active site pocket [active] 412965002313 cleavage site 412965002314 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 412965002315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412965002316 dimer interface [polypeptide binding]; other site 412965002317 conserved gate region; other site 412965002318 putative PBP binding loops; other site 412965002319 ABC-ATPase subunit interface; other site 412965002320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412965002321 dimer interface [polypeptide binding]; other site 412965002322 conserved gate region; other site 412965002323 putative PBP binding loops; other site 412965002324 ABC-ATPase subunit interface; other site 412965002325 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 412965002326 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 412965002327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412965002328 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 412965002329 Walker A/P-loop; other site 412965002330 ATP binding site [chemical binding]; other site 412965002331 Q-loop/lid; other site 412965002332 ABC transporter signature motif; other site 412965002333 Walker B; other site 412965002334 D-loop; other site 412965002335 H-loop/switch region; other site 412965002336 multicopper oxidase; Provisional; Region: PRK10965 412965002337 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 412965002338 Multicopper oxidase; Region: Cu-oxidase; pfam00394 412965002339 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 412965002340 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 412965002341 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 412965002342 Imelysin; Region: Peptidase_M75; pfam09375 412965002343 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 412965002344 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 412965002345 Imelysin; Region: Peptidase_M75; cl09159 412965002346 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 412965002347 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 412965002348 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412965002349 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412965002350 catalytic residues [active] 412965002351 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 412965002352 ArsC family; Region: ArsC; pfam03960 412965002353 putative catalytic residues [active] 412965002354 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 412965002355 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 412965002356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412965002357 Gram-negative bacterial tonB protein; Region: TonB; cl10048 412965002358 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 412965002359 TolR protein; Region: tolR; TIGR02801 412965002360 TolQ protein; Region: tolQ; TIGR02796 412965002361 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 412965002362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002363 Walker A motif; other site 412965002364 ATP binding site [chemical binding]; other site 412965002365 Walker B motif; other site 412965002366 arginine finger; other site 412965002367 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 412965002368 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 412965002369 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 412965002370 tRNA; other site 412965002371 putative tRNA binding site [nucleotide binding]; other site 412965002372 putative NADP binding site [chemical binding]; other site 412965002373 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 412965002374 peptide chain release factor 1; Validated; Region: prfA; PRK00591 412965002375 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412965002376 RF-1 domain; Region: RF-1; pfam00472 412965002377 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 412965002378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412965002379 ABC-ATPase subunit interface; other site 412965002380 dimer interface [polypeptide binding]; other site 412965002381 putative PBP binding regions; other site 412965002382 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412965002383 metal binding site 2 [ion binding]; metal-binding site 412965002384 putative DNA binding helix; other site 412965002385 metal binding site 1 [ion binding]; metal-binding site 412965002386 dimer interface [polypeptide binding]; other site 412965002387 structural Zn2+ binding site [ion binding]; other site 412965002388 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 412965002389 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 412965002390 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 412965002391 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 412965002392 tandem repeat interface [polypeptide binding]; other site 412965002393 oligomer interface [polypeptide binding]; other site 412965002394 active site residues [active] 412965002395 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 412965002396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965002397 Walker A/P-loop; other site 412965002398 ATP binding site [chemical binding]; other site 412965002399 Q-loop/lid; other site 412965002400 ABC transporter signature motif; other site 412965002401 Walker B; other site 412965002402 D-loop; other site 412965002403 H-loop/switch region; other site 412965002404 heme exporter protein CcmB; Region: ccmB; TIGR01190 412965002405 S-adenosylmethionine synthetase; Validated; Region: PRK05250 412965002406 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 412965002407 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 412965002408 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 412965002409 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 412965002410 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 412965002411 homotetramer interface [polypeptide binding]; other site 412965002412 ligand binding site [chemical binding]; other site 412965002413 catalytic site [active] 412965002414 NAD binding site [chemical binding]; other site 412965002415 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 412965002416 dimer interface [polypeptide binding]; other site 412965002417 motif 1; other site 412965002418 active site 412965002419 motif 2; other site 412965002420 motif 3; other site 412965002421 Predicted membrane protein [Function unknown]; Region: COG1238 412965002422 Peptidase family M23; Region: Peptidase_M23; pfam01551 412965002423 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 412965002424 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 412965002425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965002426 FeS/SAM binding site; other site 412965002427 TRAM domain; Region: TRAM; pfam01938 412965002428 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412965002429 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 412965002430 Cu(I) binding site [ion binding]; other site 412965002431 Protein of unknown function (DUF461); Region: DUF461; pfam04314 412965002432 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 412965002433 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 412965002434 Ligand Binding Site [chemical binding]; other site 412965002435 putative lysogenization regulator; Reviewed; Region: PRK00218 412965002436 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 412965002437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 412965002438 Smr domain; Region: Smr; pfam01713 412965002439 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 412965002440 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 412965002441 generic binding surface II; other site 412965002442 generic binding surface I; other site 412965002443 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 412965002444 substrate binding site; other site 412965002445 dimer interface; other site 412965002446 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 412965002447 homotrimer interaction site [polypeptide binding]; other site 412965002448 zinc binding site [ion binding]; other site 412965002449 CDP-binding sites; other site 412965002450 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 412965002451 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412965002452 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965002453 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412965002454 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 412965002455 FAD binding domain; Region: FAD_binding_4; pfam01565 412965002456 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 412965002457 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 412965002458 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 412965002459 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412965002460 BolA-like protein; Region: BolA; cl00386 412965002461 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 412965002462 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 412965002463 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 412965002464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965002465 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 412965002466 YccA-like proteins; Region: YccA_like; cd10433 412965002467 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 412965002468 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 412965002469 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 412965002470 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 412965002471 threonine synthase; Reviewed; Region: PRK06721 412965002472 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 412965002473 homodimer interface [polypeptide binding]; other site 412965002474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002475 catalytic residue [active] 412965002476 cysteine synthase B; Region: cysM; TIGR01138 412965002477 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412965002478 dimer interface [polypeptide binding]; other site 412965002479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002480 catalytic residue [active] 412965002481 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 412965002482 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 412965002483 putative ion selectivity filter; other site 412965002484 putative pore gating glutamate residue; other site 412965002485 putative H+/Cl- coupling transport residue; other site 412965002486 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 412965002487 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 412965002488 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 412965002489 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412965002490 P loop; other site 412965002491 GTP binding site [chemical binding]; other site 412965002492 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 412965002493 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 412965002494 domain interfaces; other site 412965002495 active site 412965002496 argininosuccinate lyase; Provisional; Region: PRK00855 412965002497 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 412965002498 active sites [active] 412965002499 tetramer interface [polypeptide binding]; other site 412965002500 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 412965002501 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 412965002502 putative active site [active] 412965002503 substrate binding site [chemical binding]; other site 412965002504 putative cosubstrate binding site; other site 412965002505 catalytic site [active] 412965002506 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 412965002507 substrate binding site [chemical binding]; other site 412965002508 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 412965002509 Clp amino terminal domain; Region: Clp_N; pfam02861 412965002510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002511 Walker A motif; other site 412965002512 ATP binding site [chemical binding]; other site 412965002513 Walker B motif; other site 412965002514 arginine finger; other site 412965002515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002516 Walker A motif; other site 412965002517 ATP binding site [chemical binding]; other site 412965002518 Walker B motif; other site 412965002519 arginine finger; other site 412965002520 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412965002521 electron transport complex RsxE subunit; Provisional; Region: PRK12405 412965002522 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 412965002523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965002524 S-adenosylmethionine binding site [chemical binding]; other site 412965002525 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 412965002526 Fumarase C-terminus; Region: Fumerase_C; pfam05683 412965002527 rod shape-determining protein MreB; Provisional; Region: PRK13927 412965002528 MreB and similar proteins; Region: MreB_like; cd10225 412965002529 nucleotide binding site [chemical binding]; other site 412965002530 Mg binding site [ion binding]; other site 412965002531 putative protofilament interaction site [polypeptide binding]; other site 412965002532 RodZ interaction site [polypeptide binding]; other site 412965002533 rod shape-determining protein MreC; Provisional; Region: PRK13922 412965002534 rod shape-determining protein MreC; Region: MreC; pfam04085 412965002535 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412965002536 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412965002537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412965002538 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 412965002539 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 412965002540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 412965002541 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 412965002542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965002543 Walker A/P-loop; other site 412965002544 ATP binding site [chemical binding]; other site 412965002545 Q-loop/lid; other site 412965002546 ABC transporter signature motif; other site 412965002547 Walker B; other site 412965002548 D-loop; other site 412965002549 H-loop/switch region; other site 412965002550 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 412965002551 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 412965002552 catalytic motif [active] 412965002553 Zn binding site [ion binding]; other site 412965002554 RibD C-terminal domain; Region: RibD_C; cl17279 412965002555 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 412965002556 Flavoprotein; Region: Flavoprotein; pfam02441 412965002557 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 412965002558 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 412965002559 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 412965002560 putative active site [active] 412965002561 putative PHP Thumb interface [polypeptide binding]; other site 412965002562 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 412965002563 generic binding surface II; other site 412965002564 generic binding surface I; other site 412965002565 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 412965002566 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 412965002567 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 412965002568 anthranilate synthase component I; Provisional; Region: PRK13565 412965002569 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412965002570 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 412965002571 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 412965002572 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 412965002573 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 412965002574 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 412965002575 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 412965002576 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 412965002577 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412965002578 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 412965002579 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412965002580 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 412965002581 DNA binding site [nucleotide binding] 412965002582 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 412965002583 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 412965002584 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 412965002585 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 412965002586 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412965002587 RPB11 interaction site [polypeptide binding]; other site 412965002588 RPB12 interaction site [polypeptide binding]; other site 412965002589 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412965002590 RPB3 interaction site [polypeptide binding]; other site 412965002591 RPB1 interaction site [polypeptide binding]; other site 412965002592 RPB11 interaction site [polypeptide binding]; other site 412965002593 RPB10 interaction site [polypeptide binding]; other site 412965002594 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 412965002595 core dimer interface [polypeptide binding]; other site 412965002596 peripheral dimer interface [polypeptide binding]; other site 412965002597 L10 interface [polypeptide binding]; other site 412965002598 L11 interface [polypeptide binding]; other site 412965002599 putative EF-Tu interaction site [polypeptide binding]; other site 412965002600 putative EF-G interaction site [polypeptide binding]; other site 412965002601 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 412965002602 23S rRNA interface [nucleotide binding]; other site 412965002603 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 412965002604 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 412965002605 mRNA/rRNA interface [nucleotide binding]; other site 412965002606 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 412965002607 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 412965002608 23S rRNA interface [nucleotide binding]; other site 412965002609 L7/L12 interface [polypeptide binding]; other site 412965002610 putative thiostrepton binding site; other site 412965002611 L25 interface [polypeptide binding]; other site 412965002612 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 412965002613 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 412965002614 putative homodimer interface [polypeptide binding]; other site 412965002615 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 412965002616 heterodimer interface [polypeptide binding]; other site 412965002617 homodimer interface [polypeptide binding]; other site 412965002618 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 412965002619 elongation factor Tu; Reviewed; Region: PRK00049 412965002620 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412965002621 G1 box; other site 412965002622 GEF interaction site [polypeptide binding]; other site 412965002623 GTP/Mg2+ binding site [chemical binding]; other site 412965002624 Switch I region; other site 412965002625 G2 box; other site 412965002626 G3 box; other site 412965002627 Switch II region; other site 412965002628 G4 box; other site 412965002629 G5 box; other site 412965002630 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412965002631 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412965002632 Antibiotic Binding Site [chemical binding]; other site 412965002633 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 412965002634 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412965002635 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 412965002636 putative NAD(P) binding site [chemical binding]; other site 412965002637 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 412965002638 nucleotide binding site/active site [active] 412965002639 HIT family signature motif; other site 412965002640 catalytic residue [active] 412965002641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 412965002642 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 412965002643 putative FMN binding site [chemical binding]; other site 412965002644 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 412965002645 dihydrodipicolinate reductase; Provisional; Region: PRK00048 412965002646 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 412965002647 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 412965002648 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 412965002649 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412965002650 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 412965002651 active site 412965002652 ribulose/triose binding site [chemical binding]; other site 412965002653 phosphate binding site [ion binding]; other site 412965002654 substrate (anthranilate) binding pocket [chemical binding]; other site 412965002655 product (indole) binding pocket [chemical binding]; other site 412965002656 OsmC-like protein; Region: OsmC; cl00767 412965002657 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 412965002658 ThiS interaction site; other site 412965002659 putative active site [active] 412965002660 tetramer interface [polypeptide binding]; other site 412965002661 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 412965002662 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 412965002663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965002664 catalytic residue [active] 412965002665 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 412965002666 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 412965002667 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 412965002668 ATP-grasp domain; Region: ATP-grasp; pfam02222 412965002669 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965002670 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 412965002671 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 412965002672 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 412965002673 homodimer interface [polypeptide binding]; other site 412965002674 NADP binding site [chemical binding]; other site 412965002675 substrate binding site [chemical binding]; other site 412965002676 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 412965002677 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 412965002678 Ligand binding site; other site 412965002679 oligomer interface; other site 412965002680 Uncharacterized conserved protein [Function unknown]; Region: COG2835 412965002681 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 412965002682 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 412965002683 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 412965002684 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412965002685 FtsX-like permease family; Region: FtsX; pfam02687 412965002686 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 412965002687 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412965002688 Walker A/P-loop; other site 412965002689 ATP binding site [chemical binding]; other site 412965002690 Q-loop/lid; other site 412965002691 ABC transporter signature motif; other site 412965002692 Walker B; other site 412965002693 D-loop; other site 412965002694 H-loop/switch region; other site 412965002695 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 412965002696 tetramerization interface [polypeptide binding]; other site 412965002697 active site 412965002698 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 412965002699 oxaloacetate decarboxylase; Provisional; Region: PRK14040 412965002700 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 412965002701 active site 412965002702 catalytic residues [active] 412965002703 metal binding site [ion binding]; metal-binding site 412965002704 homodimer binding site [polypeptide binding]; other site 412965002705 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412965002706 carboxyltransferase (CT) interaction site; other site 412965002707 biotinylation site [posttranslational modification]; other site 412965002708 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 412965002709 rRNA binding site [nucleotide binding]; other site 412965002710 predicted 30S ribosome binding site; other site 412965002711 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 412965002712 FAD binding site [chemical binding]; other site 412965002713 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 412965002714 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 412965002715 active site 412965002716 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 412965002717 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 412965002718 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 412965002719 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965002720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412965002721 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 412965002722 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 412965002723 catalytic triad [active] 412965002724 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 412965002725 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 412965002726 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 412965002727 4Fe-4S binding domain; Region: Fer4_6; pfam12837 412965002728 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 412965002729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412965002730 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412965002731 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 412965002732 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412965002733 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 412965002734 DsrC like protein; Region: DsrC; pfam04358 412965002735 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 412965002736 DsrH like protein; Region: DsrH; pfam04077 412965002737 DsrE/DsrF-like family; Region: DrsE; cl00672 412965002738 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 412965002739 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 412965002740 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412965002741 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 412965002742 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 412965002743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412965002744 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 412965002745 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 412965002746 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 412965002747 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412965002748 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 412965002749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412965002750 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 412965002751 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 412965002752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412965002753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 412965002754 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 412965002755 IMP binding site; other site 412965002756 dimer interface [polypeptide binding]; other site 412965002757 interdomain contacts; other site 412965002758 partial ornithine binding site; other site 412965002759 VacJ like lipoprotein; Region: VacJ; cl01073 412965002760 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 412965002761 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 412965002762 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 412965002763 catalytic site [active] 412965002764 subunit interface [polypeptide binding]; other site 412965002765 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 412965002766 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 412965002767 thiS-thiF/thiG interaction site; other site 412965002768 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 412965002769 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 412965002770 Ligand Binding Site [chemical binding]; other site 412965002771 DsrC like protein; Region: DsrC; cl01101 412965002772 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 412965002773 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 412965002774 motif 1; other site 412965002775 active site 412965002776 motif 2; other site 412965002777 motif 3; other site 412965002778 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412965002779 hypothetical protein; Region: PHA01516 412965002780 DHHA1 domain; Region: DHHA1; pfam02272 412965002781 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 412965002782 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 412965002783 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 412965002784 active site 412965002785 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 412965002786 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 412965002787 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 412965002788 glutaminase active site [active] 412965002789 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 412965002790 dimer interface [polypeptide binding]; other site 412965002791 active site 412965002792 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 412965002793 dimer interface [polypeptide binding]; other site 412965002794 active site 412965002795 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 412965002796 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 412965002797 dimer interface [polypeptide binding]; other site 412965002798 active site 412965002799 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 412965002800 dimer interface [polypeptide binding]; other site 412965002801 active site 412965002802 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 412965002803 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412965002804 active site 412965002805 tetramer interface; other site 412965002806 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412965002807 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 412965002808 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 412965002809 putative ADP-binding pocket [chemical binding]; other site 412965002810 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 412965002811 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 412965002812 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965002813 active site 412965002814 HIGH motif; other site 412965002815 nucleotide binding site [chemical binding]; other site 412965002816 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 412965002817 KMSKS motif; other site 412965002818 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 412965002819 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 412965002820 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 412965002821 Clp amino terminal domain; Region: Clp_N; pfam02861 412965002822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002823 Walker A motif; other site 412965002824 ATP binding site [chemical binding]; other site 412965002825 Walker B motif; other site 412965002826 arginine finger; other site 412965002827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002828 Walker A motif; other site 412965002829 ATP binding site [chemical binding]; other site 412965002830 Walker B motif; other site 412965002831 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412965002832 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 412965002833 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412965002834 GMP synthase; Reviewed; Region: guaA; PRK00074 412965002835 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 412965002836 AMP/PPi binding site [chemical binding]; other site 412965002837 candidate oxyanion hole; other site 412965002838 catalytic triad [active] 412965002839 potential glutamine specificity residues [chemical binding]; other site 412965002840 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 412965002841 ATP Binding subdomain [chemical binding]; other site 412965002842 Ligand Binding sites [chemical binding]; other site 412965002843 Dimerization subdomain; other site 412965002844 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 412965002845 nucleoside/Zn binding site; other site 412965002846 dimer interface [polypeptide binding]; other site 412965002847 catalytic motif [active] 412965002848 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 412965002849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002850 NAD(P) binding site [chemical binding]; other site 412965002851 active site 412965002852 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 412965002853 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412965002854 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 412965002855 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 412965002856 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 412965002857 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 412965002858 active site 412965002859 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 412965002860 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 412965002861 putative active site [active] 412965002862 putative metal binding site [ion binding]; other site 412965002863 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 412965002864 RNB domain; Region: RNB; pfam00773 412965002865 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 412965002866 lipoyl attachment site [posttranslational modification]; other site 412965002867 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 412965002868 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 412965002869 Intracellular septation protein A; Region: IspA; cl01098 412965002870 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412965002871 homotrimer interaction site [polypeptide binding]; other site 412965002872 putative active site [active] 412965002873 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 412965002874 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 412965002875 ssDNA binding site; other site 412965002876 generic binding surface II; other site 412965002877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412965002878 ATP binding site [chemical binding]; other site 412965002879 putative Mg++ binding site [ion binding]; other site 412965002880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965002881 nucleotide binding region [chemical binding]; other site 412965002882 ATP-binding site [chemical binding]; other site 412965002883 Chorismate lyase; Region: Chor_lyase; cl01230 412965002884 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 412965002885 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 412965002886 glutamine binding [chemical binding]; other site 412965002887 catalytic triad [active] 412965002888 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412965002889 active site residue [active] 412965002890 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965002891 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 412965002892 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 412965002893 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 412965002894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412965002895 catalytic core [active] 412965002896 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 412965002897 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 412965002898 23S rRNA interface [nucleotide binding]; other site 412965002899 L3 interface [polypeptide binding]; other site 412965002900 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 412965002901 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412965002902 ATP binding site [chemical binding]; other site 412965002903 Mg++ binding site [ion binding]; other site 412965002904 motif III; other site 412965002905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965002906 nucleotide binding region [chemical binding]; other site 412965002907 ATP-binding site [chemical binding]; other site 412965002908 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 412965002909 putative RNA binding site [nucleotide binding]; other site 412965002910 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 412965002911 DNA-binding site [nucleotide binding]; DNA binding site 412965002912 RNA-binding motif; other site 412965002913 exonuclease I; Provisional; Region: sbcB; PRK11779 412965002914 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 412965002915 active site 412965002916 catalytic site [active] 412965002917 substrate binding site [chemical binding]; other site 412965002918 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 412965002919 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 412965002920 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412965002921 minor groove reading motif; other site 412965002922 helix-hairpin-helix signature motif; other site 412965002923 substrate binding pocket [chemical binding]; other site 412965002924 active site 412965002925 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 412965002926 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 412965002927 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 412965002928 putative active site [active] 412965002929 oxyanion strand; other site 412965002930 catalytic triad [active] 412965002931 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 412965002932 putative active site pocket [active] 412965002933 4-fold oligomerization interface [polypeptide binding]; other site 412965002934 metal binding residues [ion binding]; metal-binding site 412965002935 3-fold/trimer interface [polypeptide binding]; other site 412965002936 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 412965002937 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412965002938 Uncharacterized conserved protein [Function unknown]; Region: COG0327 412965002939 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 412965002940 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 412965002941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412965002942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002943 homodimer interface [polypeptide binding]; other site 412965002944 catalytic residue [active] 412965002945 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 412965002946 dimer interface [polypeptide binding]; other site 412965002947 substrate binding site [chemical binding]; other site 412965002948 ATP binding site [chemical binding]; other site 412965002949 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 412965002950 catalytic residues [active] 412965002951 hinge region; other site 412965002952 alpha helical domain; other site 412965002953 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 412965002954 catalytic center binding site [active] 412965002955 ATP binding site [chemical binding]; other site 412965002956 Dihydroneopterin aldolase; Region: FolB; smart00905 412965002957 active site 412965002958 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 412965002959 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 412965002960 inner membrane transport permease; Provisional; Region: PRK15066 412965002961 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 412965002962 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412965002963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412965002964 Walker A/P-loop; other site 412965002965 ATP binding site [chemical binding]; other site 412965002966 Q-loop/lid; other site 412965002967 ABC transporter signature motif; other site 412965002968 Walker B; other site 412965002969 D-loop; other site 412965002970 H-loop/switch region; other site 412965002971 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 412965002972 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412965002973 E3 interaction surface; other site 412965002974 lipoyl attachment site [posttranslational modification]; other site 412965002975 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412965002976 E3 interaction surface; other site 412965002977 lipoyl attachment site [posttranslational modification]; other site 412965002978 e3 binding domain; Region: E3_binding; pfam02817 412965002979 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 412965002980 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 412965002981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 412965002982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965002983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412965002984 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 412965002985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965002986 S-adenosylmethionine binding site [chemical binding]; other site 412965002987 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 412965002988 Protein export membrane protein; Region: SecD_SecF; cl14618 412965002989 L-aspartate oxidase; Provisional; Region: PRK09077 412965002990 L-aspartate oxidase; Provisional; Region: PRK06175 412965002991 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412965002992 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412965002993 active site 412965002994 catalytic residues [active] 412965002995 metal binding site [ion binding]; metal-binding site 412965002996 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 412965002997 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 412965002998 purine monophosphate binding site [chemical binding]; other site 412965002999 dimer interface [polypeptide binding]; other site 412965003000 putative catalytic residues [active] 412965003001 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 412965003002 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 412965003003 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412965003004 ATP binding site [chemical binding]; other site 412965003005 Mg++ binding site [ion binding]; other site 412965003006 motif III; other site 412965003007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965003008 nucleotide binding region [chemical binding]; other site 412965003009 ATP-binding site [chemical binding]; other site 412965003010 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 412965003011 putative RNA binding site [nucleotide binding]; other site 412965003012 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 412965003013 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 412965003014 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 412965003015 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 412965003016 peptidase PmbA; Provisional; Region: PRK11040 412965003017 Family description; Region: DsbD_2; pfam13386 412965003018 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 412965003019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412965003020 Transporter associated domain; Region: CorC_HlyC; smart01091 412965003021 hypothetical protein; Validated; Region: PRK01777 412965003022 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 412965003023 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 412965003024 catalytic residues [active] 412965003025 UGMP family protein; Validated; Region: PRK09604 412965003026 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 412965003027 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 412965003028 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 412965003029 Walker A/P-loop; other site 412965003030 ATP binding site [chemical binding]; other site 412965003031 Q-loop/lid; other site 412965003032 ABC transporter signature motif; other site 412965003033 Walker B; other site 412965003034 D-loop; other site 412965003035 H-loop/switch region; other site 412965003036 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 412965003037 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 412965003038 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 412965003039 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 412965003040 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 412965003041 dimerization interface 3.5A [polypeptide binding]; other site 412965003042 active site 412965003043 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 412965003044 transmembrane helices; other site 412965003045 TrkA-C domain; Region: TrkA_C; pfam02080 412965003046 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 412965003047 TrkA-C domain; Region: TrkA_C; pfam02080 412965003048 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 412965003049 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 412965003050 active site clefts [active] 412965003051 zinc binding site [ion binding]; other site 412965003052 dimer interface [polypeptide binding]; other site 412965003053 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 412965003054 RimM N-terminal domain; Region: RimM; pfam01782 412965003055 PRC-barrel domain; Region: PRC; pfam05239 412965003056 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 412965003057 adenylosuccinate lyase; Provisional; Region: PRK09285 412965003058 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 412965003059 tetramer interface [polypeptide binding]; other site 412965003060 active site 412965003061 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 412965003062 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 412965003063 substrate binding site [chemical binding]; other site 412965003064 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 412965003065 substrate binding site [chemical binding]; other site 412965003066 ligand binding site [chemical binding]; other site 412965003067 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 412965003068 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 412965003069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412965003070 active site 412965003071 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 412965003072 putative active site [active] 412965003073 putative catalytic site [active] 412965003074 putative DNA binding site [nucleotide binding]; other site 412965003075 putative phosphate binding site [ion binding]; other site 412965003076 metal binding site A [ion binding]; metal-binding site 412965003077 putative AP binding site [nucleotide binding]; other site 412965003078 putative metal binding site B [ion binding]; other site 412965003079 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 412965003080 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 412965003081 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 412965003082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965003083 amidophosphoribosyltransferase; Provisional; Region: PRK09246 412965003084 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 412965003085 active site 412965003086 tetramer interface [polypeptide binding]; other site 412965003087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412965003088 active site 412965003089 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 412965003090 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412965003091 homodimer interface [polypeptide binding]; other site 412965003092 substrate-cofactor binding pocket; other site 412965003093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965003094 catalytic residue [active] 412965003095 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 412965003096 active site 1 [active] 412965003097 dimer interface [polypeptide binding]; other site 412965003098 active site 2 [active] 412965003099 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 412965003100 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412965003101 dimer interface [polypeptide binding]; other site 412965003102 active site 412965003103 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 412965003104 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412965003105 Protein export membrane protein; Region: SecD_SecF; pfam02355 412965003106 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 412965003107 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 412965003108 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412965003109 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 412965003110 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 412965003111 seryl-tRNA synthetase; Provisional; Region: PRK05431 412965003112 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 412965003113 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 412965003114 dimer interface [polypeptide binding]; other site 412965003115 active site 412965003116 motif 1; other site 412965003117 motif 2; other site 412965003118 motif 3; other site 412965003119 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412965003120 active site residue [active] 412965003121 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412965003122 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 412965003123 catalytic residues [active] 412965003124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412965003125 active site residue [active] 412965003126 transcriptional regulator NarL; Provisional; Region: PRK10651 412965003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412965003128 active site 412965003129 phosphorylation site [posttranslational modification] 412965003130 intermolecular recognition site; other site 412965003131 dimerization interface [polypeptide binding]; other site 412965003132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412965003133 DNA binding residues [nucleotide binding] 412965003134 dimerization interface [polypeptide binding]; other site 412965003135 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 412965003136 GAF domain; Region: GAF_3; pfam13492 412965003137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 412965003138 Histidine kinase; Region: HisKA_3; pfam07730 412965003139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965003140 ATP binding site [chemical binding]; other site 412965003141 Mg2+ binding site [ion binding]; other site 412965003142 G-X-G motif; other site 412965003143 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 412965003144 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 412965003145 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 412965003146 GTP/Mg2+ binding site [chemical binding]; other site 412965003147 G4 box; other site 412965003148 G5 box; other site 412965003149 trmE is a tRNA modification GTPase; Region: trmE; cd04164 412965003150 G1 box; other site 412965003151 G1 box; other site 412965003152 GTP/Mg2+ binding site [chemical binding]; other site 412965003153 Switch I region; other site 412965003154 Switch I region; other site 412965003155 G2 box; other site 412965003156 G2 box; other site 412965003157 Switch II region; other site 412965003158 G3 box; other site 412965003159 G3 box; other site 412965003160 Switch II region; other site 412965003161 G4 box; other site 412965003162 G5 box; other site 412965003163 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 412965003164 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 412965003165 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412965003166 thiamine phosphate binding site [chemical binding]; other site 412965003167 active site 412965003168 pyrophosphate binding site [ion binding]; other site 412965003169 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 412965003170 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 412965003171 active site 412965003172 dimer interface [polypeptide binding]; other site 412965003173 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 412965003174 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 412965003175 active site 412965003176 FMN binding site [chemical binding]; other site 412965003177 substrate binding site [chemical binding]; other site 412965003178 3Fe-4S cluster binding site [ion binding]; other site 412965003179 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 412965003180 domain interface; other site 412965003181 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 412965003182 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 412965003183 folate binding site [chemical binding]; other site 412965003184 NADP+ binding site [chemical binding]; other site 412965003185 Maf-like protein; Region: Maf; pfam02545 412965003186 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 412965003187 active site 412965003188 dimer interface [polypeptide binding]; other site 412965003189 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 412965003190 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 412965003191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412965003192 ATP binding site [chemical binding]; other site 412965003193 putative Mg++ binding site [ion binding]; other site 412965003194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965003195 nucleotide binding region [chemical binding]; other site 412965003196 ATP-binding site [chemical binding]; other site 412965003197 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 412965003198 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 412965003199 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412965003200 substrate binding site [chemical binding]; other site 412965003201 ATP binding site [chemical binding]; other site 412965003202 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 412965003203 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 412965003204 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 412965003205 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412965003206 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 412965003207 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 412965003208 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 412965003209 substrate binding site [chemical binding]; other site 412965003210 active site 412965003211 catalytic residues [active] 412965003212 heterodimer interface [polypeptide binding]; other site 412965003213 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 412965003214 substrate binding site [chemical binding]; other site 412965003215 active site 412965003216 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 412965003217 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 412965003218 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412965003219 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412965003220 metal-binding site [ion binding] 412965003221 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412965003222 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 412965003223 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 412965003224 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 412965003225 Substrate binding site; other site 412965003226 Mg++ binding site; other site 412965003227 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 412965003228 active site 412965003229 substrate binding site [chemical binding]; other site 412965003230 CoA binding site [chemical binding]; other site 412965003231 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 412965003232 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 412965003233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965003234 catalytic residue [active] 412965003235 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 412965003236 active site 412965003237 DNA topoisomerase I; Provisional; Region: PRK08780 412965003238 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 412965003239 active site 412965003240 interdomain interaction site; other site 412965003241 putative metal-binding site [ion binding]; other site 412965003242 nucleotide binding site [chemical binding]; other site 412965003243 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412965003244 domain I; other site 412965003245 DNA binding groove [nucleotide binding] 412965003246 phosphate binding site [ion binding]; other site 412965003247 domain II; other site 412965003248 domain III; other site 412965003249 nucleotide binding site [chemical binding]; other site 412965003250 catalytic site [active] 412965003251 domain IV; other site 412965003252 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 412965003253 Protein of unknown function (DUF494); Region: DUF494; pfam04361 412965003254 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 412965003255 Ribonuclease P; Region: Ribonuclease_P; pfam00825 412965003256 Haemolytic domain; Region: Haemolytic; pfam01809 412965003257 membrane protein insertase; Provisional; Region: PRK01318 412965003258 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 412965003259 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412965003260 active site 412965003261 iron coordination sites [ion binding]; other site 412965003262 substrate binding pocket [chemical binding]; other site 412965003263 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 412965003264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965003265 active site 412965003266 motif I; other site 412965003267 motif II; other site 412965003268 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 412965003269 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 412965003270 gamma subunit interface [polypeptide binding]; other site 412965003271 epsilon subunit interface [polypeptide binding]; other site 412965003272 LBP interface [polypeptide binding]; other site 412965003273 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 412965003274 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412965003275 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 412965003276 alpha subunit interaction interface [polypeptide binding]; other site 412965003277 Walker A motif; other site 412965003278 ATP binding site [chemical binding]; other site 412965003279 Walker B motif; other site 412965003280 inhibitor binding site; inhibition site 412965003281 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412965003282 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 412965003283 core domain interface [polypeptide binding]; other site 412965003284 delta subunit interface [polypeptide binding]; other site 412965003285 epsilon subunit interface [polypeptide binding]; other site 412965003286 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 412965003287 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412965003288 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 412965003289 beta subunit interaction interface [polypeptide binding]; other site 412965003290 Walker A motif; other site 412965003291 ATP binding site [chemical binding]; other site 412965003292 Walker B motif; other site 412965003293 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412965003294 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 412965003295 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 412965003296 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 412965003297 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 412965003298 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 412965003299 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 412965003300 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 412965003301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 412965003302 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 412965003303 ATP-NAD kinase; Region: NAD_kinase; pfam01513 412965003304 GrpE; Region: GrpE; pfam01025 412965003305 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 412965003306 dimer interface [polypeptide binding]; other site 412965003307 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 412965003308 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 412965003309 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 412965003310 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 412965003311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965003312 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 412965003313 DsbD alpha interface [polypeptide binding]; other site 412965003314 catalytic residues [active] 412965003315 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 412965003316 Dehydroquinase class II; Region: DHquinase_II; pfam01220 412965003317 active site 412965003318 trimer interface [polypeptide binding]; other site 412965003319 dimer interface [polypeptide binding]; other site 412965003320 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 412965003321 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412965003322 carboxyltransferase (CT) interaction site; other site 412965003323 biotinylation site [posttranslational modification]; other site 412965003324 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 412965003325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412965003326 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 412965003327 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 412965003328 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 412965003329 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 412965003330 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 412965003331 citrate synthase; Provisional; Region: PRK14036 412965003332 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 412965003333 dimer interface [polypeptide binding]; other site 412965003334 active site 412965003335 citrylCoA binding site [chemical binding]; other site 412965003336 oxalacetate/citrate binding site [chemical binding]; other site 412965003337 coenzyme A binding site [chemical binding]; other site 412965003338 catalytic triad [active] 412965003339 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 412965003340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965003341 S-adenosylmethionine binding site [chemical binding]; other site 412965003342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 412965003343 ABC1 family; Region: ABC1; cl17513 412965003344 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 412965003345 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 412965003346 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 412965003347 5S rRNA interface [nucleotide binding]; other site 412965003348 CTC domain interface [polypeptide binding]; other site 412965003349 L16 interface [polypeptide binding]; other site 412965003350 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 412965003351 putative active site [active] 412965003352 catalytic residue [active] 412965003353 GTP-binding protein YchF; Reviewed; Region: PRK09601 412965003354 YchF GTPase; Region: YchF; cd01900 412965003355 G1 box; other site 412965003356 GTP/Mg2+ binding site [chemical binding]; other site 412965003357 Switch I region; other site 412965003358 G2 box; other site 412965003359 Switch II region; other site 412965003360 G3 box; other site 412965003361 G4 box; other site 412965003362 G5 box; other site 412965003363 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 412965003364 phosphoglyceromutase; Provisional; Region: PRK05434 412965003365 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 412965003366 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 412965003367 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 412965003368 substrate binding site [chemical binding]; other site 412965003369 hexamer interface [polypeptide binding]; other site 412965003370 metal binding site [ion binding]; metal-binding site 412965003371 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 412965003372 rRNA interaction site [nucleotide binding]; other site 412965003373 S8 interaction site; other site 412965003374 putative laminin-1 binding site; other site 412965003375 elongation factor Ts; Provisional; Region: tsf; PRK09377 412965003376 UBA/TS-N domain; Region: UBA; pfam00627 412965003377 Elongation factor TS; Region: EF_TS; pfam00889 412965003378 Elongation factor TS; Region: EF_TS; pfam00889 412965003379 triosephosphate isomerase; Provisional; Region: PRK14567 412965003380 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 412965003381 substrate binding site [chemical binding]; other site 412965003382 dimer interface [polypeptide binding]; other site 412965003383 catalytic triad [active] 412965003384 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350