-- dump date 20140619_025636 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521097000001 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 521097000002 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 521097000003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521097000004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521097000005 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 521097000006 dimerization interface [polypeptide binding]; other site 521097000007 carboxy-terminal protease; Provisional; Region: PRK11186 521097000008 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521097000009 protein binding site [polypeptide binding]; other site 521097000010 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521097000011 Catalytic dyad [active] 521097000012 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 521097000013 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 521097000014 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521097000015 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521097000016 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 521097000017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521097000018 Zn2+ binding site [ion binding]; other site 521097000019 Mg2+ binding site [ion binding]; other site 521097000020 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 521097000021 synthetase active site [active] 521097000022 NTP binding site [chemical binding]; other site 521097000023 metal binding site [ion binding]; metal-binding site 521097000024 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 521097000025 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 521097000026 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 521097000027 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521097000028 active site 521097000029 catalytic site [active] 521097000030 substrate binding site [chemical binding]; other site 521097000031 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 521097000032 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 521097000033 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 521097000034 TrkA-N domain; Region: TrkA_N; pfam02254 521097000035 TrkA-C domain; Region: TrkA_C; pfam02080 521097000036 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 521097000037 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 521097000038 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 521097000039 Conserved TM helix; Region: TM_helix; pfam05552 521097000040 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521097000041 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 521097000042 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 521097000043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 521097000044 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 521097000045 active site 521097000046 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 521097000047 catalytic site [active] 521097000048 BNR repeat-like domain; Region: BNR_2; pfam13088 521097000049 Asp-box motif; other site 521097000050 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 521097000051 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 521097000052 PhnA protein; Region: PhnA; pfam03831 521097000053 EthD domain; Region: EthD; pfam07110 521097000054 SnoaL-like domain; Region: SnoaL_2; pfam12680 521097000055 heat shock protein 90; Provisional; Region: PRK05218 521097000056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097000057 ATP binding site [chemical binding]; other site 521097000058 Mg2+ binding site [ion binding]; other site 521097000059 G-X-G motif; other site 521097000060 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 521097000061 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 521097000062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097000063 ATP binding site [chemical binding]; other site 521097000064 putative Mg++ binding site [ion binding]; other site 521097000065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097000066 nucleotide binding region [chemical binding]; other site 521097000067 ATP-binding site [chemical binding]; other site 521097000068 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 521097000069 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 521097000070 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 521097000071 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521097000072 E3 interaction surface; other site 521097000073 lipoyl attachment site [posttranslational modification]; other site 521097000074 e3 binding domain; Region: E3_binding; pfam02817 521097000075 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521097000076 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 521097000077 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 521097000078 nucleotide binding site [chemical binding]; other site 521097000079 SulA interaction site; other site 521097000080 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 521097000081 Cell division protein FtsA; Region: FtsA; smart00842 521097000082 Cell division protein FtsA; Region: FtsA; pfam14450 521097000083 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 521097000084 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 521097000085 Ligand binding site; other site 521097000086 oligomer interface; other site 521097000087 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 521097000088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521097000089 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 521097000090 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 521097000091 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 521097000092 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 521097000093 carboxyltransferase (CT) interaction site; other site 521097000094 biotinylation site [posttranslational modification]; other site 521097000095 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 521097000096 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 521097000097 dimer interface [polypeptide binding]; other site 521097000098 active site 521097000099 CoA binding pocket [chemical binding]; other site 521097000100 HYR domain; Region: HYR; pfam02494 521097000101 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 521097000102 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 521097000103 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 521097000104 active site 521097000105 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521097000106 dimer interface [polypeptide binding]; other site 521097000107 substrate binding site [chemical binding]; other site 521097000108 catalytic residues [active] 521097000109 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 521097000110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521097000111 substrate binding site [chemical binding]; other site 521097000112 oxyanion hole (OAH) forming residues; other site 521097000113 trimer interface [polypeptide binding]; other site 521097000114 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 521097000115 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521097000116 catalytic loop [active] 521097000117 iron binding site [ion binding]; other site 521097000118 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 521097000119 FAD binding pocket [chemical binding]; other site 521097000120 FAD binding motif [chemical binding]; other site 521097000121 phosphate binding motif [ion binding]; other site 521097000122 beta-alpha-beta structure motif; other site 521097000123 NAD binding pocket [chemical binding]; other site 521097000124 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 521097000125 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 521097000126 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 521097000127 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 521097000128 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 521097000129 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 521097000130 DinB superfamily; Region: DinB_2; pfam12867 521097000131 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 521097000132 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 521097000133 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 521097000134 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 521097000135 Family description; Region: VCBS; pfam13517 521097000136 Family description; Region: VCBS; pfam13517 521097000137 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521097000138 RHS Repeat; Region: RHS_repeat; pfam05593 521097000139 RHS Repeat; Region: RHS_repeat; pfam05593 521097000140 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521097000141 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521097000142 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 521097000143 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 521097000144 GTP cyclohydrolase I; Provisional; Region: PLN03044 521097000145 active site 521097000146 Found in ATP-dependent protease La (LON); Region: LON; smart00464 521097000147 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 521097000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097000149 Walker A motif; other site 521097000150 ATP binding site [chemical binding]; other site 521097000151 Walker B motif; other site 521097000152 arginine finger; other site 521097000153 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 521097000154 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 521097000155 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 521097000156 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 521097000157 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 521097000158 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521097000159 Beta-lactamase; Region: Beta-lactamase; pfam00144 521097000160 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 521097000161 CoA binding domain; Region: CoA_binding; smart00881 521097000162 CoA-ligase; Region: Ligase_CoA; pfam00549 521097000163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521097000164 E3 interaction surface; other site 521097000165 lipoyl attachment site [posttranslational modification]; other site 521097000166 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 521097000167 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521097000168 E3 interaction surface; other site 521097000169 lipoyl attachment site [posttranslational modification]; other site 521097000170 e3 binding domain; Region: E3_binding; pfam02817 521097000171 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521097000172 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 521097000173 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 521097000174 tetramer interface [polypeptide binding]; other site 521097000175 TPP-binding site [chemical binding]; other site 521097000176 heterodimer interface [polypeptide binding]; other site 521097000177 phosphorylation loop region [posttranslational modification] 521097000178 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 521097000179 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 521097000180 active site 521097000181 Fn3 associated; Region: Fn3_assoc; pfam13287 521097000182 GSCFA family; Region: GSCFA; pfam08885 521097000183 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 521097000184 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 521097000185 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 521097000186 DNA binding site [nucleotide binding] 521097000187 active site 521097000188 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 521097000189 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 521097000190 Dehydroquinase class II; Region: DHquinase_II; pfam01220 521097000191 active site 521097000192 trimer interface [polypeptide binding]; other site 521097000193 dimer interface [polypeptide binding]; other site 521097000194 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 521097000195 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 521097000196 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 521097000197 putative active site [active] 521097000198 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 521097000199 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 521097000200 LrgA family; Region: LrgA; pfam03788 521097000201 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 521097000202 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 521097000203 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521097000204 active site 521097000205 catalytic site [active] 521097000206 substrate binding site [chemical binding]; other site 521097000207 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521097000208 GIY-YIG motif/motif A; other site 521097000209 active site 521097000210 catalytic site [active] 521097000211 putative DNA binding site [nucleotide binding]; other site 521097000212 metal binding site [ion binding]; metal-binding site 521097000213 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 521097000214 HemN C-terminal domain; Region: HemN_C; pfam06969 521097000215 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 521097000216 active site 521097000217 putative DNA-binding cleft [nucleotide binding]; other site 521097000218 dimer interface [polypeptide binding]; other site 521097000219 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 521097000220 active site pocket [active] 521097000221 oxyanion hole [active] 521097000222 catalytic triad [active] 521097000223 active site nucleophile [active] 521097000224 Protein of unknown function (DUF493); Region: DUF493; pfam04359 521097000225 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 521097000226 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521097000227 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521097000228 hinge; other site 521097000229 active site 521097000230 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 521097000231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521097000232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097000233 homodimer interface [polypeptide binding]; other site 521097000234 catalytic residue [active] 521097000235 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 521097000236 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521097000237 Mg++ binding site [ion binding]; other site 521097000238 putative catalytic motif [active] 521097000239 putative substrate binding site [chemical binding]; other site 521097000240 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 521097000241 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 521097000242 Ion transport protein; Region: Ion_trans; pfam00520 521097000243 Ion channel; Region: Ion_trans_2; pfam07885 521097000244 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 521097000245 putative hydrolase; Provisional; Region: PRK11460 521097000246 dihydroorotase; Validated; Region: pyrC; PRK09357 521097000247 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 521097000248 active site 521097000249 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521097000250 nudix motif; other site 521097000251 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 521097000252 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521097000253 DXD motif; other site 521097000254 Protein of unknown function (DUF419); Region: DUF419; pfam04237 521097000255 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 521097000256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521097000257 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 521097000258 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 521097000259 FMN binding site [chemical binding]; other site 521097000260 substrate binding site [chemical binding]; other site 521097000261 putative catalytic residue [active] 521097000262 GTP-binding protein YchF; Reviewed; Region: PRK09601 521097000263 YchF GTPase; Region: YchF; cd01900 521097000264 G1 box; other site 521097000265 GTP/Mg2+ binding site [chemical binding]; other site 521097000266 Switch I region; other site 521097000267 G2 box; other site 521097000268 Switch II region; other site 521097000269 G3 box; other site 521097000270 G4 box; other site 521097000271 G5 box; other site 521097000272 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521097000273 triosephosphate isomerase; Provisional; Region: PRK14567 521097000274 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521097000275 substrate binding site [chemical binding]; other site 521097000276 dimer interface [polypeptide binding]; other site 521097000277 catalytic triad [active] 521097000278 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 521097000279 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 521097000280 substrate binding site [chemical binding]; other site 521097000281 active site 521097000282 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 521097000283 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521097000284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097000285 catalytic residue [active] 521097000286 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 521097000287 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 521097000288 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 521097000289 RimM N-terminal domain; Region: RimM; pfam01782 521097000290 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 521097000291 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 521097000292 tetramerization interface [polypeptide binding]; other site 521097000293 active site 521097000294 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 521097000295 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521097000296 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521097000297 catalytic residues [active] 521097000298 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521097000299 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521097000300 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521097000301 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521097000302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521097000303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521097000304 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 521097000305 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 521097000306 active site 521097000307 intersubunit interface [polypeptide binding]; other site 521097000308 zinc binding site [ion binding]; other site 521097000309 Na+ binding site [ion binding]; other site 521097000310 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 521097000311 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 521097000312 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521097000313 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521097000314 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521097000315 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521097000316 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521097000317 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521097000318 Walker A/P-loop; other site 521097000319 ATP binding site [chemical binding]; other site 521097000320 Q-loop/lid; other site 521097000321 ABC transporter signature motif; other site 521097000322 Walker B; other site 521097000323 D-loop; other site 521097000324 H-loop/switch region; other site 521097000325 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521097000326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521097000327 Walker A/P-loop; other site 521097000328 ATP binding site [chemical binding]; other site 521097000329 Q-loop/lid; other site 521097000330 ABC transporter signature motif; other site 521097000331 Walker B; other site 521097000332 D-loop; other site 521097000333 H-loop/switch region; other site 521097000334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097000335 S-adenosylmethionine binding site [chemical binding]; other site 521097000336 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 521097000337 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 521097000338 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097000339 Outer membrane efflux protein; Region: OEP; pfam02321 521097000340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521097000341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521097000342 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 521097000343 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 521097000344 motif 1; other site 521097000345 active site 521097000346 motif 2; other site 521097000347 motif 3; other site 521097000348 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521097000349 DHHA1 domain; Region: DHHA1; pfam02272 521097000350 Protein of unknown function, DUF479; Region: DUF479; cl01203 521097000351 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 521097000352 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521097000353 RNA binding site [nucleotide binding]; other site 521097000354 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 521097000355 RNA binding site [nucleotide binding]; other site 521097000356 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521097000357 RNA binding site [nucleotide binding]; other site 521097000358 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521097000359 RNA binding site [nucleotide binding]; other site 521097000360 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 521097000361 RNA binding site [nucleotide binding]; other site 521097000362 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 521097000363 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 521097000364 G1 box; other site 521097000365 putative GEF interaction site [polypeptide binding]; other site 521097000366 GTP/Mg2+ binding site [chemical binding]; other site 521097000367 Switch I region; other site 521097000368 G2 box; other site 521097000369 G3 box; other site 521097000370 Switch II region; other site 521097000371 G4 box; other site 521097000372 G5 box; other site 521097000373 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 521097000374 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 521097000375 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 521097000376 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521097000377 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521097000378 active site 521097000379 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 521097000380 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521097000381 acyl-activating enzyme (AAE) consensus motif; other site 521097000382 AMP binding site [chemical binding]; other site 521097000383 active site 521097000384 CoA binding site [chemical binding]; other site 521097000385 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 521097000386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521097000387 4Fe-4S binding domain; Region: Fer4; pfam00037 521097000388 inner membrane protein; Provisional; Region: PRK11715 521097000389 Transcriptional regulators [Transcription]; Region: MarR; COG1846 521097000390 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 521097000391 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521097000392 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521097000393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521097000394 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 521097000395 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 521097000396 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521097000397 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 521097000398 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 521097000399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521097000400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521097000401 Hydrogenase formation hypA family; Region: HypD; cl12072 521097000402 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 521097000403 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 521097000404 Int/Topo IB signature motif; other site 521097000405 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521097000406 Peptidase family M23; Region: Peptidase_M23; pfam01551 521097000407 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097000408 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 521097000409 Outer membrane efflux protein; Region: OEP; pfam02321 521097000410 Outer membrane efflux protein; Region: OEP; pfam02321 521097000411 Domain of unknown function (DUF368); Region: DUF368; pfam04018 521097000412 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 521097000413 YtxH-like protein; Region: YtxH; pfam12732 521097000414 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 521097000415 MutS domain III; Region: MutS_III; pfam05192 521097000416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097000417 Walker A/P-loop; other site 521097000418 ATP binding site [chemical binding]; other site 521097000419 Q-loop/lid; other site 521097000420 ABC transporter signature motif; other site 521097000421 Walker B; other site 521097000422 D-loop; other site 521097000423 H-loop/switch region; other site 521097000424 CTP synthetase; Validated; Region: pyrG; PRK05380 521097000425 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521097000426 Catalytic site [active] 521097000427 active site 521097000428 UTP binding site [chemical binding]; other site 521097000429 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521097000430 active site 521097000431 putative oxyanion hole; other site 521097000432 catalytic triad [active] 521097000433 membrane protein insertase; Provisional; Region: PRK01318 521097000434 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 521097000435 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 521097000436 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 521097000437 Family description; Region: VCBS; pfam13517 521097000438 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 521097000439 RHS Repeat; Region: RHS_repeat; pfam05593 521097000440 RHS Repeat; Region: RHS_repeat; pfam05593 521097000441 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 521097000442 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 521097000443 SIR2-like domain; Region: SIR2_2; pfam13289 521097000444 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097000445 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097000446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097000447 active site 521097000448 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 521097000449 transmembrane helices; other site 521097000450 TrkA-C domain; Region: TrkA_C; pfam02080 521097000451 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521097000452 TrkA-C domain; Region: TrkA_C; pfam02080 521097000453 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 521097000454 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 521097000455 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 521097000456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097000457 catalytic residue [active] 521097000458 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 521097000459 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 521097000460 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 521097000461 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 521097000462 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 521097000463 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521097000464 active site 521097000465 dimerization interface [polypeptide binding]; other site 521097000466 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521097000467 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521097000468 Walker A/P-loop; other site 521097000469 ATP binding site [chemical binding]; other site 521097000470 Q-loop/lid; other site 521097000471 ABC transporter signature motif; other site 521097000472 Walker B; other site 521097000473 D-loop; other site 521097000474 H-loop/switch region; other site 521097000475 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521097000476 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 521097000477 DXD motif; other site 521097000478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097000479 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 521097000480 NAD(P) binding site [chemical binding]; other site 521097000481 active site 521097000482 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 521097000483 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 521097000484 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 521097000485 Response regulator receiver domain; Region: Response_reg; pfam00072 521097000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097000487 active site 521097000488 phosphorylation site [posttranslational modification] 521097000489 intermolecular recognition site; other site 521097000490 dimerization interface [polypeptide binding]; other site 521097000491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097000492 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521097000493 Walker A motif; other site 521097000494 ATP binding site [chemical binding]; other site 521097000495 Walker B motif; other site 521097000496 arginine finger; other site 521097000497 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 521097000498 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 521097000499 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 521097000500 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521097000501 Serine hydrolase; Region: Ser_hydrolase; cl17834 521097000502 Putative methyltransferase; Region: Methyltransf_20; pfam12147 521097000503 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 521097000504 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 521097000505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097000506 active site 521097000507 HIGH motif; other site 521097000508 nucleotide binding site [chemical binding]; other site 521097000509 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521097000510 KMSK motif region; other site 521097000511 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521097000512 tRNA binding surface [nucleotide binding]; other site 521097000513 anticodon binding site; other site 521097000514 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 521097000515 lipoyl attachment site [posttranslational modification]; other site 521097000516 VanZ like family; Region: VanZ; cl01971 521097000517 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 521097000518 GH3 auxin-responsive promoter; Region: GH3; pfam03321 521097000519 replicative DNA helicase; Region: DnaB; TIGR00665 521097000520 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521097000521 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521097000522 Walker A motif; other site 521097000523 ATP binding site [chemical binding]; other site 521097000524 Walker B motif; other site 521097000525 DNA binding loops [nucleotide binding] 521097000526 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 521097000527 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 521097000528 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 521097000529 Aspartase; Region: Aspartase; cd01357 521097000530 active sites [active] 521097000531 tetramer interface [polypeptide binding]; other site 521097000532 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 521097000533 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 521097000534 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521097000535 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521097000536 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521097000537 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 521097000538 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 521097000539 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521097000540 sugar binding site [chemical binding]; other site 521097000541 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097000542 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097000543 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097000544 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097000545 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097000546 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097000547 SusD family; Region: SusD; pfam07980 521097000548 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097000549 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097000550 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097000551 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 521097000552 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097000553 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097000554 SusD family; Region: SusD; pfam07980 521097000555 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 521097000556 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 521097000557 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 521097000558 active site 521097000559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521097000560 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 521097000561 active site 521097000562 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 521097000563 active site 2 [active] 521097000564 active site 1 [active] 521097000565 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 521097000566 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 521097000567 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 521097000568 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 521097000569 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521097000570 active site 521097000571 catalytic residues [active] 521097000572 metal binding site [ion binding]; metal-binding site 521097000573 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 521097000574 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 521097000575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097000576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097000577 dimer interface [polypeptide binding]; other site 521097000578 phosphorylation site [posttranslational modification] 521097000579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097000580 ATP binding site [chemical binding]; other site 521097000581 Mg2+ binding site [ion binding]; other site 521097000582 G-X-G motif; other site 521097000583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521097000584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097000585 active site 521097000586 phosphorylation site [posttranslational modification] 521097000587 intermolecular recognition site; other site 521097000588 dimerization interface [polypeptide binding]; other site 521097000589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521097000590 DNA binding site [nucleotide binding] 521097000591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 521097000592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097000593 Coenzyme A binding pocket [chemical binding]; other site 521097000594 GTPase Era; Reviewed; Region: era; PRK00089 521097000595 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 521097000596 G1 box; other site 521097000597 GTP/Mg2+ binding site [chemical binding]; other site 521097000598 Switch I region; other site 521097000599 G2 box; other site 521097000600 Switch II region; other site 521097000601 G3 box; other site 521097000602 G4 box; other site 521097000603 G5 box; other site 521097000604 KH domain; Region: KH_2; pfam07650 521097000605 cell division protein FtsQ; Provisional; Region: PRK05529 521097000606 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 521097000607 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 521097000608 NAD binding site [chemical binding]; other site 521097000609 substrate binding site [chemical binding]; other site 521097000610 homodimer interface [polypeptide binding]; other site 521097000611 active site 521097000612 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 521097000613 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 521097000614 Predicted membrane protein [Function unknown]; Region: COG2323 521097000615 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521097000616 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 521097000617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097000618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097000619 dimer interface [polypeptide binding]; other site 521097000620 phosphorylation site [posttranslational modification] 521097000621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097000622 ATP binding site [chemical binding]; other site 521097000623 Mg2+ binding site [ion binding]; other site 521097000624 G-X-G motif; other site 521097000625 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521097000626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097000627 active site 521097000628 phosphorylation site [posttranslational modification] 521097000629 intermolecular recognition site; other site 521097000630 dimerization interface [polypeptide binding]; other site 521097000631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521097000632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097000633 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521097000634 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 521097000635 putative substrate binding site [chemical binding]; other site 521097000636 putative ATP binding site [chemical binding]; other site 521097000637 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 521097000638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097000639 putative substrate translocation pore; other site 521097000640 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 521097000641 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 521097000642 substrate binding [chemical binding]; other site 521097000643 active site 521097000644 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 521097000645 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 521097000646 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 521097000647 active site 521097000648 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 521097000649 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 521097000650 starch binding outer membrane protein SusD; Region: SusD; cl17845 521097000651 SusD family; Region: SusD; pfam07980 521097000652 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097000653 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097000654 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097000655 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 521097000656 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 521097000657 Chorismate mutase type II; Region: CM_2; smart00830 521097000658 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 521097000659 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 521097000660 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521097000661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521097000662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521097000663 DNA binding residues [nucleotide binding] 521097000664 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 521097000665 Protein of unknown function (DUF535); Region: DUF535; cl01128 521097000666 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 521097000667 putative active site [active] 521097000668 putative catalytic site [active] 521097000669 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 521097000670 active site 521097000671 homotetramer interface [polypeptide binding]; other site 521097000672 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521097000673 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 521097000674 Ligand binding site; other site 521097000675 Putative Catalytic site; other site 521097000676 DXD motif; other site 521097000677 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 521097000678 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 521097000679 catalytic residues [active] 521097000680 dimer interface [polypeptide binding]; other site 521097000681 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 521097000682 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 521097000683 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 521097000684 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 521097000685 L-aspartate oxidase; Provisional; Region: PRK06175 521097000686 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 521097000687 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 521097000688 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 521097000689 putative Iron-sulfur protein interface [polypeptide binding]; other site 521097000690 proximal heme binding site [chemical binding]; other site 521097000691 distal heme binding site [chemical binding]; other site 521097000692 putative dimer interface [polypeptide binding]; other site 521097000693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521097000694 metal-binding site [ion binding] 521097000695 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 521097000696 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521097000697 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521097000698 Helix-turn-helix domain; Region: HTH_18; pfam12833 521097000699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097000700 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097000701 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 521097000702 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521097000703 metal binding site 2 [ion binding]; metal-binding site 521097000704 putative DNA binding helix; other site 521097000705 metal binding site 1 [ion binding]; metal-binding site 521097000706 dimer interface [polypeptide binding]; other site 521097000707 structural Zn2+ binding site [ion binding]; other site 521097000708 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 521097000709 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 521097000710 GDP-binding site [chemical binding]; other site 521097000711 ACT binding site; other site 521097000712 IMP binding site; other site 521097000713 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 521097000714 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 521097000715 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521097000716 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 521097000717 MoxR-like ATPases [General function prediction only]; Region: COG0714 521097000718 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 521097000719 Walker A motif; other site 521097000720 ATP binding site [chemical binding]; other site 521097000721 Walker B motif; other site 521097000722 arginine finger; other site 521097000723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521097000724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521097000725 PIF1-like helicase; Region: PIF1; pfam05970 521097000726 Family description; Region: UvrD_C_2; pfam13538 521097000727 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 521097000728 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521097000729 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 521097000730 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 521097000731 active site 521097000732 homodimer interface [polypeptide binding]; other site 521097000733 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 521097000734 putative acyl-acceptor binding pocket; other site 521097000735 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 521097000736 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521097000737 active site 521097000738 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097000739 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097000740 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097000741 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097000742 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097000743 S-adenosylmethionine synthetase; Validated; Region: PRK05250 521097000744 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521097000745 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521097000746 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521097000747 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521097000748 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521097000749 catalytic residues [active] 521097000750 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 521097000751 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 521097000752 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 521097000753 catalytic site [active] 521097000754 subunit interface [polypeptide binding]; other site 521097000755 DinB family; Region: DinB; cl17821 521097000756 enolase; Provisional; Region: eno; PRK00077 521097000757 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521097000758 dimer interface [polypeptide binding]; other site 521097000759 metal binding site [ion binding]; metal-binding site 521097000760 substrate binding pocket [chemical binding]; other site 521097000761 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097000762 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 521097000763 putative hydrolase; Provisional; Region: PRK02113 521097000764 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 521097000765 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097000766 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097000767 ligand binding site [chemical binding]; other site 521097000768 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 521097000769 nucleotide binding site [chemical binding]; other site 521097000770 substrate binding site [chemical binding]; other site 521097000771 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 521097000772 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 521097000773 dimer interface [polypeptide binding]; other site 521097000774 motif 1; other site 521097000775 active site 521097000776 motif 2; other site 521097000777 motif 3; other site 521097000778 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521097000779 anticodon binding site; other site 521097000780 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 521097000781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 521097000782 homodimer interface [polypeptide binding]; other site 521097000783 metal binding site [ion binding]; metal-binding site 521097000784 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 521097000785 homodimer interface [polypeptide binding]; other site 521097000786 active site 521097000787 putative chemical substrate binding site [chemical binding]; other site 521097000788 metal binding site [ion binding]; metal-binding site 521097000789 MarR family; Region: MarR_2; pfam12802 521097000790 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521097000791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521097000792 nucleotide binding site [chemical binding]; other site 521097000793 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 521097000794 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 521097000795 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521097000796 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521097000797 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097000798 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 521097000799 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521097000800 metal ion-dependent adhesion site (MIDAS); other site 521097000801 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 521097000802 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 521097000803 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 521097000804 YcfA-like protein; Region: YcfA; pfam07927 521097000805 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 521097000806 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 521097000807 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 521097000808 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 521097000809 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 521097000810 putative acyl-acceptor binding pocket; other site 521097000811 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521097000812 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521097000813 catalytic residues [active] 521097000814 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 521097000815 nucleotide binding site/active site [active] 521097000816 HIT family signature motif; other site 521097000817 catalytic residue [active] 521097000818 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 521097000819 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521097000820 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521097000821 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 521097000822 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521097000823 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521097000824 catalytic residue [active] 521097000825 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521097000826 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 521097000827 UbiA prenyltransferase family; Region: UbiA; pfam01040 521097000828 Sel1-like repeats; Region: SEL1; smart00671 521097000829 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 521097000830 Sel1-like repeats; Region: SEL1; smart00671 521097000831 Sel1-like repeats; Region: SEL1; smart00671 521097000832 Sel1-like repeats; Region: SEL1; smart00671 521097000833 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 521097000834 Sel1-like repeats; Region: SEL1; smart00671 521097000835 TPR repeat; Region: TPR_11; pfam13414 521097000836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097000837 binding surface 521097000838 TPR motif; other site 521097000839 Sel1-like repeats; Region: SEL1; smart00671 521097000840 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 521097000841 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 521097000842 Transglycosylase; Region: Transgly; pfam00912 521097000843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 521097000844 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 521097000845 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 521097000846 RuvA N terminal domain; Region: RuvA_N; pfam01330 521097000847 PIN domain; Region: PIN_2; cl17859 521097000848 Lipopolysaccharide-assembly; Region: LptE; pfam04390 521097000849 Preprotein translocase SecG subunit; Region: SecG; pfam03840 521097000850 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521097000851 oligomerisation interface [polypeptide binding]; other site 521097000852 mobile loop; other site 521097000853 roof hairpin; other site 521097000854 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521097000855 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521097000856 ring oligomerisation interface [polypeptide binding]; other site 521097000857 ATP/Mg binding site [chemical binding]; other site 521097000858 stacking interactions; other site 521097000859 hinge regions; other site 521097000860 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097000861 ligand binding site [chemical binding]; other site 521097000862 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521097000863 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 521097000864 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 521097000865 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521097000866 putative acyl-acceptor binding pocket; other site 521097000867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 521097000868 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 521097000869 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 521097000870 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 521097000871 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 521097000872 homopentamer interface [polypeptide binding]; other site 521097000873 active site 521097000874 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 521097000875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097000876 binding surface 521097000877 TPR motif; other site 521097000878 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 521097000879 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521097000880 dimerization interface [polypeptide binding]; other site 521097000881 DPS ferroxidase diiron center [ion binding]; other site 521097000882 ion pore; other site 521097000883 DinB superfamily; Region: DinB_2; pfam12867 521097000884 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521097000885 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521097000886 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 521097000887 putative ABC transporter; Region: ycf24; CHL00085 521097000888 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 521097000889 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 521097000890 substrate binding site [chemical binding]; other site 521097000891 hexamer interface [polypeptide binding]; other site 521097000892 metal binding site [ion binding]; metal-binding site 521097000893 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 521097000894 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 521097000895 active site 521097000896 interdomain interaction site; other site 521097000897 putative metal-binding site [ion binding]; other site 521097000898 nucleotide binding site [chemical binding]; other site 521097000899 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521097000900 domain I; other site 521097000901 DNA binding groove [nucleotide binding] 521097000902 phosphate binding site [ion binding]; other site 521097000903 domain II; other site 521097000904 domain III; other site 521097000905 nucleotide binding site [chemical binding]; other site 521097000906 catalytic site [active] 521097000907 domain IV; other site 521097000908 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 521097000909 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 521097000910 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521097000911 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521097000912 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521097000913 Walker A/P-loop; other site 521097000914 ATP binding site [chemical binding]; other site 521097000915 Q-loop/lid; other site 521097000916 ABC transporter signature motif; other site 521097000917 Walker B; other site 521097000918 D-loop; other site 521097000919 H-loop/switch region; other site 521097000920 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 521097000921 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 521097000922 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 521097000923 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 521097000924 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 521097000925 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521097000926 inhibitor-cofactor binding pocket; inhibition site 521097000927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097000928 catalytic residue [active] 521097000929 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 521097000930 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 521097000931 active site 521097000932 Smr domain; Region: Smr; cl02619 521097000933 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521097000934 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521097000935 Walker A/P-loop; other site 521097000936 ATP binding site [chemical binding]; other site 521097000937 Q-loop/lid; other site 521097000938 ABC transporter signature motif; other site 521097000939 Walker B; other site 521097000940 D-loop; other site 521097000941 H-loop/switch region; other site 521097000942 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 521097000943 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 521097000944 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 521097000945 flavoprotein, HI0933 family; Region: TIGR00275 521097000946 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 521097000947 dimer interface [polypeptide binding]; other site 521097000948 catalytic triad [active] 521097000949 peroxidatic and resolving cysteines [active] 521097000950 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521097000951 DHH family; Region: DHH; pfam01368 521097000952 DHHA1 domain; Region: DHHA1; pfam02272 521097000953 Clostripain family; Region: Peptidase_C11; pfam03415 521097000954 Prominin; Region: Prominin; pfam05478 521097000955 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521097000956 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 521097000957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521097000958 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521097000959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521097000960 DNA binding residues [nucleotide binding] 521097000961 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 521097000962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521097000963 active site 521097000964 GTPase RsgA; Reviewed; Region: PRK00098 521097000965 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 521097000966 RNA binding site [nucleotide binding]; other site 521097000967 homodimer interface [polypeptide binding]; other site 521097000968 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521097000969 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521097000970 GTP/Mg2+ binding site [chemical binding]; other site 521097000971 G4 box; other site 521097000972 G5 box; other site 521097000973 G1 box; other site 521097000974 Switch I region; other site 521097000975 G2 box; other site 521097000976 G3 box; other site 521097000977 Switch II region; other site 521097000978 Colicin V production protein; Region: Colicin_V; pfam02674 521097000979 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_4; pfam13583 521097000980 active site 521097000981 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097000982 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_4; pfam13583 521097000983 active site 521097000984 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097000985 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 521097000986 active site 521097000987 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 521097000988 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097000989 Zeta toxin; Region: Zeta_toxin; pfam06414 521097000990 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 521097000991 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 521097000992 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 521097000993 Ca binding site [ion binding]; other site 521097000994 active site 521097000995 homodimer interface [polypeptide binding]; other site 521097000996 catalytic site [active] 521097000997 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 521097000998 hypothetical protein; Validated; Region: PRK02101 521097000999 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 521097001000 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097001001 Sodium Bile acid symporter family; Region: SBF; cl17470 521097001002 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 521097001003 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521097001004 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521097001005 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 521097001006 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521097001007 active site 521097001008 catalytic site [active] 521097001009 substrate binding site [chemical binding]; other site 521097001010 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 521097001011 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 521097001012 active site 521097001013 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521097001014 generic binding surface II; other site 521097001015 generic binding surface I; other site 521097001016 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 521097001017 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521097001018 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 521097001019 putative dimer interface [polypeptide binding]; other site 521097001020 putative anticodon binding site; other site 521097001021 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521097001022 homodimer interface [polypeptide binding]; other site 521097001023 motif 1; other site 521097001024 motif 2; other site 521097001025 active site 521097001026 motif 3; other site 521097001027 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 521097001028 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097001029 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097001030 active site 521097001031 oxyanion hole [active] 521097001032 catalytic triad [active] 521097001033 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521097001034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097001035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097001036 ABC transporter; Region: ABC_tran_2; pfam12848 521097001037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097001038 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 521097001039 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 521097001040 Predicted membrane protein [Function unknown]; Region: COG2259 521097001041 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 521097001042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521097001043 active site 521097001044 DNA binding site [nucleotide binding] 521097001045 Int/Topo IB signature motif; other site 521097001046 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 521097001047 Predicted exporter [General function prediction only]; Region: COG4258 521097001048 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521097001049 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521097001050 putative acyl-acceptor binding pocket; other site 521097001051 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 521097001052 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521097001053 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521097001054 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097001055 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521097001056 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521097001057 Walker A/P-loop; other site 521097001058 ATP binding site [chemical binding]; other site 521097001059 Q-loop/lid; other site 521097001060 ABC transporter signature motif; other site 521097001061 Walker B; other site 521097001062 D-loop; other site 521097001063 H-loop/switch region; other site 521097001064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521097001065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521097001066 WHG domain; Region: WHG; pfam13305 521097001067 CAAX protease self-immunity; Region: Abi; cl00558 521097001068 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 521097001069 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521097001070 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521097001071 FtsX-like permease family; Region: FtsX; pfam02687 521097001072 Histidine kinase; Region: His_kinase; pfam06580 521097001073 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 521097001074 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521097001075 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521097001076 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 521097001077 Lumazine binding domain; Region: Lum_binding; pfam00677 521097001078 Lumazine binding domain; Region: Lum_binding; pfam00677 521097001079 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521097001080 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521097001081 putative acyl-acceptor binding pocket; other site 521097001082 DinB superfamily; Region: DinB_2; pfam12867 521097001083 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521097001084 thiamine-monophosphate kinase; Region: thiL; TIGR01379 521097001085 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 521097001086 ATP binding site [chemical binding]; other site 521097001087 dimerization interface [polypeptide binding]; other site 521097001088 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 521097001089 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 521097001090 active site 521097001091 dimer interface [polypeptide binding]; other site 521097001092 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521097001093 Cation efflux family; Region: Cation_efflux; pfam01545 521097001094 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 521097001095 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 521097001096 Mg++ binding site [ion binding]; other site 521097001097 putative catalytic motif [active] 521097001098 substrate binding site [chemical binding]; other site 521097001099 Bacterial sugar transferase; Region: Bac_transf; pfam02397 521097001100 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 521097001101 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 521097001102 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 521097001103 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 521097001104 Peptidase S46; Region: Peptidase_S46; pfam10459 521097001105 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521097001106 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 521097001107 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 521097001108 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 521097001109 metal ion-dependent adhesion site (MIDAS); other site 521097001110 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097001111 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 521097001112 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 521097001113 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 521097001114 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 521097001115 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 521097001116 nucleotide binding site [chemical binding]; other site 521097001117 substrate binding site [chemical binding]; other site 521097001118 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521097001119 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 521097001120 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 521097001121 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 521097001122 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 521097001123 FAD binding site [chemical binding]; other site 521097001124 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 521097001125 G1 box; other site 521097001126 GTP/Mg2+ binding site [chemical binding]; other site 521097001127 Switch I region; other site 521097001128 G2 box; other site 521097001129 G3 box; other site 521097001130 Switch II region; other site 521097001131 G4 box; other site 521097001132 G5 box; other site 521097001133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521097001134 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 521097001135 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 521097001136 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 521097001137 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 521097001138 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 521097001139 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097001140 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097001141 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097001142 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 521097001143 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 521097001144 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521097001145 putative homodimer interface [polypeptide binding]; other site 521097001146 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 521097001147 heterodimer interface [polypeptide binding]; other site 521097001148 homodimer interface [polypeptide binding]; other site 521097001149 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521097001150 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521097001151 23S rRNA interface [nucleotide binding]; other site 521097001152 L7/L12 interface [polypeptide binding]; other site 521097001153 putative thiostrepton binding site; other site 521097001154 L25 interface [polypeptide binding]; other site 521097001155 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521097001156 mRNA/rRNA interface [nucleotide binding]; other site 521097001157 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521097001158 23S rRNA interface [nucleotide binding]; other site 521097001159 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521097001160 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521097001161 core dimer interface [polypeptide binding]; other site 521097001162 peripheral dimer interface [polypeptide binding]; other site 521097001163 L10 interface [polypeptide binding]; other site 521097001164 L11 interface [polypeptide binding]; other site 521097001165 putative EF-Tu interaction site [polypeptide binding]; other site 521097001166 putative EF-G interaction site [polypeptide binding]; other site 521097001167 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 521097001168 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 521097001169 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 521097001170 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521097001171 RPB11 interaction site [polypeptide binding]; other site 521097001172 RPB12 interaction site [polypeptide binding]; other site 521097001173 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521097001174 RPB3 interaction site [polypeptide binding]; other site 521097001175 RPB1 interaction site [polypeptide binding]; other site 521097001176 RPB11 interaction site [polypeptide binding]; other site 521097001177 RPB10 interaction site [polypeptide binding]; other site 521097001178 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 521097001179 Protein of unknown function (DUF805); Region: DUF805; pfam05656 521097001180 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 521097001181 Sel1-like repeats; Region: SEL1; smart00671 521097001182 Sel1-like repeats; Region: SEL1; smart00671 521097001183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 521097001184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097001185 Coenzyme A binding pocket [chemical binding]; other site 521097001186 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521097001187 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 521097001188 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 521097001189 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521097001190 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521097001191 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 521097001192 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521097001193 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 521097001194 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521097001195 DNA binding site [nucleotide binding] 521097001196 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521097001197 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 521097001198 Predicted transcriptional regulators [Transcription]; Region: COG1695 521097001199 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 521097001200 PspC domain; Region: PspC; pfam04024 521097001201 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 521097001202 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 521097001203 active site 521097001204 catalytic triad [active] 521097001205 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 521097001206 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 521097001207 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 521097001208 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521097001209 Sulfatase; Region: Sulfatase; cl17466 521097001210 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 521097001211 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 521097001212 CAP-like domain; other site 521097001213 active site 521097001214 primary dimer interface [polypeptide binding]; other site 521097001215 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 521097001216 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097001217 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001218 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097001219 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097001220 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097001221 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097001222 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 521097001223 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 521097001224 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097001225 active site 521097001226 catalytic triad [active] 521097001227 oxyanion hole [active] 521097001228 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 521097001229 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 521097001230 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 521097001231 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 521097001232 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 521097001233 putative active site [active] 521097001234 catalytic triad [active] 521097001235 putative dimer interface [polypeptide binding]; other site 521097001236 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 521097001237 active sites [active] 521097001238 tetramer interface [polypeptide binding]; other site 521097001239 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 521097001240 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 521097001241 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 521097001242 Potassium binding sites [ion binding]; other site 521097001243 Cesium cation binding sites [ion binding]; other site 521097001244 Surface antigen; Region: Bac_surface_Ag; pfam01103 521097001245 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521097001246 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 521097001247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521097001248 heat shock protein GrpE; Provisional; Region: PRK14141 521097001249 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521097001250 dimer interface [polypeptide binding]; other site 521097001251 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521097001252 chaperone protein DnaJ; Provisional; Region: PRK10767 521097001253 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521097001254 HSP70 interaction site [polypeptide binding]; other site 521097001255 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521097001256 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521097001257 dimer interface [polypeptide binding]; other site 521097001258 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 521097001259 dimer interface [polypeptide binding]; other site 521097001260 FMN binding site [chemical binding]; other site 521097001261 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 521097001262 dimer interface [polypeptide binding]; other site 521097001263 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521097001264 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521097001265 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 521097001266 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521097001267 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 521097001268 ligand binding site [chemical binding]; other site 521097001269 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 521097001270 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 521097001271 dimer interface [polypeptide binding]; other site 521097001272 active site 521097001273 CoA binding pocket [chemical binding]; other site 521097001274 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 521097001275 DNA polymerase III, delta subunit; Region: holA; TIGR01128 521097001276 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 521097001277 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 521097001278 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 521097001279 Probable Catalytic site; other site 521097001280 metal-binding site 521097001281 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521097001282 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521097001283 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097001284 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 521097001285 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 521097001286 DEAD/DEAH box helicase; Region: DEAD; pfam00270 521097001287 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 521097001288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097001289 nucleotide binding region [chemical binding]; other site 521097001290 ATP-binding site [chemical binding]; other site 521097001291 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 521097001292 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 521097001293 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 521097001294 ATP binding site [chemical binding]; other site 521097001295 Mg++ binding site [ion binding]; other site 521097001296 motif III; other site 521097001297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097001298 nucleotide binding region [chemical binding]; other site 521097001299 ATP-binding site [chemical binding]; other site 521097001300 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 521097001301 RNA binding site [nucleotide binding]; other site 521097001302 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 521097001303 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521097001304 active site 521097001305 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 521097001306 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 521097001307 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 521097001308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097001309 motif II; other site 521097001310 Chain length determinant protein; Region: Wzz; pfam02706 521097001311 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 521097001312 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 521097001313 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 521097001314 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 521097001315 SLBB domain; Region: SLBB; pfam10531 521097001316 SLBB domain; Region: SLBB; pfam10531 521097001317 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 521097001318 SLBB domain; Region: SLBB; pfam10531 521097001319 SLBB domain; Region: SLBB; pfam10531 521097001320 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 521097001321 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 521097001322 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 521097001323 active site 521097001324 metal binding site [ion binding]; metal-binding site 521097001325 DoxX; Region: DoxX; pfam07681 521097001326 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 521097001327 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 521097001328 HflX GTPase family; Region: HflX; cd01878 521097001329 G1 box; other site 521097001330 GTP/Mg2+ binding site [chemical binding]; other site 521097001331 Switch I region; other site 521097001332 G2 box; other site 521097001333 G3 box; other site 521097001334 Switch II region; other site 521097001335 G4 box; other site 521097001336 G5 box; other site 521097001337 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 521097001338 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 521097001339 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521097001340 FMN binding site [chemical binding]; other site 521097001341 active site 521097001342 catalytic residues [active] 521097001343 substrate binding site [chemical binding]; other site 521097001344 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521097001345 Ligand binding site; other site 521097001346 Putative Catalytic site; other site 521097001347 DXD motif; other site 521097001348 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 521097001349 RIP metalloprotease RseP; Region: TIGR00054 521097001350 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521097001351 active site 521097001352 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521097001353 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521097001354 protein binding site [polypeptide binding]; other site 521097001355 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 521097001356 putative substrate binding region [chemical binding]; other site 521097001357 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 521097001358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097001359 FeS/SAM binding site; other site 521097001360 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 521097001361 dimer interface [polypeptide binding]; other site 521097001362 FMN binding site [chemical binding]; other site 521097001363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097001364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521097001365 putative substrate translocation pore; other site 521097001366 2TM domain; Region: 2TM; pfam13239 521097001367 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 521097001368 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 521097001369 folate binding site [chemical binding]; other site 521097001370 NADP+ binding site [chemical binding]; other site 521097001371 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521097001372 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 521097001373 putative acyl-acceptor binding pocket; other site 521097001374 GTPase CgtA; Reviewed; Region: obgE; PRK12299 521097001375 GTP1/OBG; Region: GTP1_OBG; pfam01018 521097001376 Obg GTPase; Region: Obg; cd01898 521097001377 G1 box; other site 521097001378 GTP/Mg2+ binding site [chemical binding]; other site 521097001379 Switch I region; other site 521097001380 G2 box; other site 521097001381 G3 box; other site 521097001382 Switch II region; other site 521097001383 G4 box; other site 521097001384 G5 box; other site 521097001385 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097001386 active site 521097001387 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521097001388 Adenylate kinase; Region: ADK; pfam00406 521097001389 AMP-binding site [chemical binding]; other site 521097001390 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521097001391 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521097001392 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 521097001393 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 521097001394 UbiA prenyltransferase family; Region: UbiA; pfam01040 521097001395 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 521097001396 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 521097001397 Cl- selectivity filter; other site 521097001398 Cl- binding residues [ion binding]; other site 521097001399 pore gating glutamate residue; other site 521097001400 dimer interface [polypeptide binding]; other site 521097001401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 521097001402 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 521097001403 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 521097001404 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 521097001405 diphosphomevalonate decarboxylase; Region: PLN02407 521097001406 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 521097001407 diphosphomevalonate decarboxylase; Region: PLN02407 521097001408 short chain dehydrogenase; Validated; Region: PRK06182 521097001409 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 521097001410 NADP binding site [chemical binding]; other site 521097001411 active site 521097001412 steroid binding site; other site 521097001413 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 521097001414 active site 521097001415 intersubunit interactions; other site 521097001416 catalytic residue [active] 521097001417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 521097001418 AAA domain; Region: AAA_33; pfam13671 521097001419 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 521097001420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521097001421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 521097001422 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 521097001423 substrate binding site [chemical binding]; other site 521097001424 oxyanion hole (OAH) forming residues; other site 521097001425 trimer interface [polypeptide binding]; other site 521097001426 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 521097001427 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 521097001428 Cysteine-rich domain; Region: CCG; pfam02754 521097001429 Cysteine-rich domain; Region: CCG; pfam02754 521097001430 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 521097001431 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 521097001432 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 521097001433 putative active site [active] 521097001434 catalytic site [active] 521097001435 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 521097001436 putative active site [active] 521097001437 catalytic site [active] 521097001438 Bacterial Ig-like domain; Region: Big_5; pfam13205 521097001439 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001440 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001441 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 521097001442 catalytic motif [active] 521097001443 Zn binding site [ion binding]; other site 521097001444 RibD C-terminal domain; Region: RibD_C; cl17279 521097001445 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 521097001446 ATP-grasp domain; Region: ATP-grasp; pfam02222 521097001447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097001448 S-adenosylmethionine binding site [chemical binding]; other site 521097001449 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 521097001450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521097001451 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521097001452 Membrane protein of unknown function; Region: DUF360; pfam04020 521097001453 AAA domain; Region: AAA_30; pfam13604 521097001454 Family description; Region: UvrD_C_2; pfam13538 521097001455 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 521097001456 ferredoxin-NADP reductase; Provisional; Region: PRK10926 521097001457 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 521097001458 Domain of unknown function (DUF389); Region: DUF389; pfam04087 521097001459 YCII-related domain; Region: YCII; cl00999 521097001460 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 521097001461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521097001462 BRO family, N-terminal domain; Region: Bro-N; cl10591 521097001463 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521097001464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521097001465 ligand binding site [chemical binding]; other site 521097001466 flexible hinge region; other site 521097001467 DinB superfamily; Region: DinB_2; pfam12867 521097001468 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097001469 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097001470 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097001471 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001472 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097001473 starch binding outer membrane protein SusD; Region: SusD; cl17845 521097001474 starch binding outer membrane protein SusD; Region: SusD; cl17845 521097001475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521097001476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097001477 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 521097001478 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521097001479 active site 2 [active] 521097001480 active site 1 [active] 521097001481 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521097001482 active site 1 [active] 521097001483 active site 2 [active] 521097001484 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 521097001485 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 521097001486 dimer interface [polypeptide binding]; other site 521097001487 active site 521097001488 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 521097001489 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 521097001490 putative acyl-acceptor binding pocket; other site 521097001491 Phosphopantetheine attachment site; Region: PP-binding; cl09936 521097001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 521097001493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097001494 binding surface 521097001495 TPR motif; other site 521097001496 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 521097001497 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 521097001498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097001499 TPR motif; other site 521097001500 binding surface 521097001501 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 521097001502 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 521097001503 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521097001504 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097001505 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521097001506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521097001507 RNA binding surface [nucleotide binding]; other site 521097001508 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521097001509 active site 521097001510 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521097001511 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521097001512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097001513 Walker A/P-loop; other site 521097001514 ATP binding site [chemical binding]; other site 521097001515 Q-loop/lid; other site 521097001516 ABC transporter signature motif; other site 521097001517 Walker B; other site 521097001518 D-loop; other site 521097001519 H-loop/switch region; other site 521097001520 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 521097001521 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 521097001522 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521097001523 dimer interface [polypeptide binding]; other site 521097001524 motif 1; other site 521097001525 active site 521097001526 motif 2; other site 521097001527 motif 3; other site 521097001528 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 521097001529 active site 521097001530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097001531 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 521097001532 putative substrate translocation pore; other site 521097001533 AAA domain; Region: AAA_33; pfam13671 521097001534 AAA domain; Region: AAA_17; pfam13207 521097001535 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 521097001536 active site 521097001537 catalytic residues [active] 521097001538 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 521097001539 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 521097001540 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 521097001541 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 521097001542 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 521097001543 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 521097001544 putative active site [active] 521097001545 dimerization interface [polypeptide binding]; other site 521097001546 putative tRNAtyr binding site [nucleotide binding]; other site 521097001547 WYL domain; Region: WYL; pfam13280 521097001548 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 521097001549 L-lactate permease; Region: Lactate_perm; cl00701 521097001550 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001551 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 521097001552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097001553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097001554 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 521097001555 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521097001556 Ligand Binding Site [chemical binding]; other site 521097001557 TilS substrate C-terminal domain; Region: TilS_C; smart00977 521097001558 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 521097001559 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 521097001560 homodimer interface [polypeptide binding]; other site 521097001561 substrate-cofactor binding pocket; other site 521097001562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097001563 catalytic residue [active] 521097001564 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 521097001565 hydrophobic ligand binding site; other site 521097001566 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521097001567 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521097001568 ligand binding site [chemical binding]; other site 521097001569 flexible hinge region; other site 521097001570 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 521097001571 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 521097001572 active site 521097001573 catalytic residues [active] 521097001574 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 521097001575 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 521097001576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097001577 S-adenosylmethionine binding site [chemical binding]; other site 521097001578 Restriction endonuclease HincII; Region: Endonuc-HincII; pfam09226 521097001579 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521097001580 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521097001581 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521097001582 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521097001583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097001584 Coenzyme A binding pocket [chemical binding]; other site 521097001585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521097001586 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 521097001587 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097001588 active site 521097001589 HIGH motif; other site 521097001590 nucleotide binding site [chemical binding]; other site 521097001591 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097001592 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097001593 active site 521097001594 KMSKS motif; other site 521097001595 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 521097001596 tRNA binding surface [nucleotide binding]; other site 521097001597 anticodon binding site; other site 521097001598 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 521097001599 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521097001600 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 521097001601 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 521097001602 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521097001603 ABC-2 type transporter; Region: ABC2_membrane; cl17235 521097001604 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 521097001605 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 521097001606 ABC-2 type transporter; Region: ABC2_membrane; cl17235 521097001607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 521097001608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521097001609 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521097001610 Coenzyme A binding pocket [chemical binding]; other site 521097001611 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 521097001612 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521097001613 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097001614 Outer membrane efflux protein; Region: OEP; pfam02321 521097001615 Outer membrane efflux protein; Region: OEP; pfam02321 521097001616 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 521097001617 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 521097001618 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 521097001619 active site 521097001620 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 521097001621 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 521097001622 dihydroorotase; Reviewed; Region: PRK09236 521097001623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521097001624 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 521097001625 active site 521097001626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 521097001627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097001628 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 521097001629 Coenzyme A binding pocket [chemical binding]; other site 521097001630 Protein of unknown function (DUF721); Region: DUF721; pfam05258 521097001631 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097001632 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 521097001633 putative active site [active] 521097001634 putative metal binding site [ion binding]; other site 521097001635 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 521097001636 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 521097001637 active site 521097001638 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521097001639 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521097001640 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 521097001641 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097001642 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 521097001643 N-terminal plug; other site 521097001644 ligand-binding site [chemical binding]; other site 521097001645 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 521097001646 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521097001647 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 521097001648 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 521097001649 active site 521097001650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097001651 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 521097001652 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 521097001653 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 521097001654 four helix bundle protein; Region: TIGR02436 521097001655 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097001656 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001657 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097001658 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097001659 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097001660 SusE outer membrane protein; Region: SusE; pfam14292 521097001661 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 521097001662 starch binding site [chemical binding]; other site 521097001663 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 521097001664 starch binding site [chemical binding]; other site 521097001665 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 521097001666 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 521097001667 active site 521097001668 Ca binding site [ion binding]; other site 521097001669 catalytic site [active] 521097001670 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 521097001671 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 521097001672 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 521097001673 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 521097001674 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 521097001675 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 521097001676 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 521097001677 Predicted transcriptional regulator [Transcription]; Region: COG2932 521097001678 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521097001679 Catalytic site [active] 521097001680 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521097001681 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521097001682 active site 521097001683 HIGH motif; other site 521097001684 dimer interface [polypeptide binding]; other site 521097001685 KMSKS motif; other site 521097001686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521097001687 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521097001688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521097001689 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 521097001690 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 521097001691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097001692 S-adenosylmethionine binding site [chemical binding]; other site 521097001693 Hemerythrin family; Region: Hemerythrin-like; cl15774 521097001694 PAS domain; Region: PAS_10; pfam13596 521097001695 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 521097001696 DNA polymerase IV; Validated; Region: PRK02406 521097001697 active site 521097001698 DNA binding site [nucleotide binding] 521097001699 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 521097001700 DNA protecting protein DprA; Region: dprA; TIGR00732 521097001701 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 521097001702 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097001703 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001704 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 521097001705 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097001706 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097001707 SusD family; Region: SusD; pfam07980 521097001708 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 521097001709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097001710 FeS/SAM binding site; other site 521097001711 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 521097001712 ATP-NAD kinase; Region: NAD_kinase; pfam01513 521097001713 beta-phosphoglucomutase; Region: bPGM; TIGR01990 521097001714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097001715 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 521097001716 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 521097001717 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 521097001718 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 521097001719 alpha subunit interface [polypeptide binding]; other site 521097001720 TPP binding site [chemical binding]; other site 521097001721 heterodimer interface [polypeptide binding]; other site 521097001722 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521097001723 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 521097001724 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 521097001725 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521097001726 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521097001727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097001728 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097001729 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521097001730 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 521097001731 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 521097001732 inhibitor-cofactor binding pocket; inhibition site 521097001733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097001734 catalytic residue [active] 521097001735 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 521097001736 Mrr N-terminal domain; Region: Mrr_N; pfam14338 521097001737 Restriction endonuclease; Region: Mrr_cat; pfam04471 521097001738 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 521097001739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521097001740 DNA methylase; Region: N6_N4_Mtase; cl17433 521097001741 AIPR protein; Region: AIPR; pfam10592 521097001742 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 521097001743 Domain of unknown function (DUF377); Region: DUF377; pfam04041 521097001744 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 521097001745 active site 521097001746 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 521097001747 Sulfatase; Region: Sulfatase; cl17466 521097001748 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 521097001749 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 521097001750 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 521097001751 active site 521097001752 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521097001753 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 521097001754 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 521097001755 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 521097001756 catalytic core [active] 521097001757 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 521097001758 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 521097001759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521097001760 active site 521097001761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521097001762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097001763 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521097001764 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521097001765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521097001766 active site 521097001767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097001768 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521097001769 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521097001770 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 521097001771 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 521097001772 active site 521097001773 homodimer interface [polypeptide binding]; other site 521097001774 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 521097001775 putative ligand binding site [chemical binding]; other site 521097001776 putative catalytic site [active] 521097001777 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521097001778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521097001779 active site 521097001780 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521097001781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521097001782 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 521097001783 NAD binding site [chemical binding]; other site 521097001784 homotetramer interface [polypeptide binding]; other site 521097001785 homodimer interface [polypeptide binding]; other site 521097001786 active site 521097001787 substrate binding site [chemical binding]; other site 521097001788 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521097001789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097001790 NAD(P) binding site [chemical binding]; other site 521097001791 active site 521097001792 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 521097001793 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 521097001794 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 521097001795 inhibitor-cofactor binding pocket; inhibition site 521097001796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097001797 catalytic residue [active] 521097001798 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 521097001799 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 521097001800 NAD binding site [chemical binding]; other site 521097001801 homotetramer interface [polypeptide binding]; other site 521097001802 homodimer interface [polypeptide binding]; other site 521097001803 substrate binding site [chemical binding]; other site 521097001804 active site 521097001805 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 521097001806 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 521097001807 substrate binding site; other site 521097001808 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521097001809 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 521097001810 catalytic loop [active] 521097001811 iron binding site [ion binding]; other site 521097001812 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 521097001813 FAD binding pocket [chemical binding]; other site 521097001814 FAD binding motif [chemical binding]; other site 521097001815 phosphate binding motif [ion binding]; other site 521097001816 beta-alpha-beta structure motif; other site 521097001817 NAD binding pocket [chemical binding]; other site 521097001818 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 521097001819 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521097001820 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 521097001821 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 521097001822 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521097001823 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 521097001824 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 521097001825 NAD(P) binding site [chemical binding]; other site 521097001826 homodimer interface [polypeptide binding]; other site 521097001827 substrate binding site [chemical binding]; other site 521097001828 active site 521097001829 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 521097001830 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 521097001831 inhibitor-cofactor binding pocket; inhibition site 521097001832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097001833 catalytic residue [active] 521097001834 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 521097001835 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 521097001836 putative trimer interface [polypeptide binding]; other site 521097001837 putative CoA binding site [chemical binding]; other site 521097001838 Bacterial sugar transferase; Region: Bac_transf; pfam02397 521097001839 O-methyltransferase; Region: Methyltransf_2; pfam00891 521097001840 ribonuclease P; Reviewed; Region: rnpA; PRK01903 521097001841 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 521097001842 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 521097001843 active site 521097001844 substrate binding site [chemical binding]; other site 521097001845 cosubstrate binding site; other site 521097001846 catalytic site [active] 521097001847 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521097001848 23S rRNA interface [nucleotide binding]; other site 521097001849 L3 interface [polypeptide binding]; other site 521097001850 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 521097001851 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521097001852 rRNA interaction site [nucleotide binding]; other site 521097001853 S8 interaction site; other site 521097001854 putative laminin-1 binding site; other site 521097001855 elongation factor Ts; Provisional; Region: tsf; PRK09377 521097001856 UBA/TS-N domain; Region: UBA; pfam00627 521097001857 Elongation factor TS; Region: EF_TS; pfam00889 521097001858 Elongation factor TS; Region: EF_TS; pfam00889 521097001859 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 521097001860 glutamate dehydrogenase; Provisional; Region: PRK14030 521097001861 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 521097001862 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 521097001863 NAD(P) binding site [chemical binding]; other site 521097001864 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 521097001865 dimer interface [polypeptide binding]; other site 521097001866 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 521097001867 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 521097001868 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 521097001869 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521097001870 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 521097001871 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 521097001872 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 521097001873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 521097001874 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 521097001875 FAD binding site [chemical binding]; other site 521097001876 homotetramer interface [polypeptide binding]; other site 521097001877 substrate binding pocket [chemical binding]; other site 521097001878 catalytic base [active] 521097001879 Rrf2 family protein; Region: rrf2_super; TIGR00738 521097001880 Transcriptional regulator; Region: Rrf2; pfam02082 521097001881 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 521097001882 seryl-tRNA synthetase; Provisional; Region: PRK05431 521097001883 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521097001884 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 521097001885 dimer interface [polypeptide binding]; other site 521097001886 active site 521097001887 motif 1; other site 521097001888 motif 2; other site 521097001889 motif 3; other site 521097001890 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 521097001891 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 521097001892 ribonuclease Z; Reviewed; Region: PRK00055 521097001893 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 521097001894 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 521097001895 active site 521097001896 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 521097001897 putative active site [active] 521097001898 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 521097001899 Phosphopantetheine attachment site; Region: PP-binding; cl09936 521097001900 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 521097001901 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521097001902 dimer interface [polypeptide binding]; other site 521097001903 active site 521097001904 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 521097001905 RNA/DNA hybrid binding site [nucleotide binding]; other site 521097001906 active site 521097001907 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 521097001908 Peptidase family M23; Region: Peptidase_M23; pfam01551 521097001909 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 521097001910 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521097001911 trimer interface [polypeptide binding]; other site 521097001912 active site 521097001913 GH3 auxin-responsive promoter; Region: GH3; pfam03321 521097001914 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 521097001915 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 521097001916 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 521097001917 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 521097001918 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 521097001919 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 521097001920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521097001921 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521097001922 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 521097001923 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521097001924 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521097001925 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 521097001926 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 521097001927 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 521097001928 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 521097001929 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 521097001930 FeoA domain; Region: FeoA; pfam04023 521097001931 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 521097001932 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 521097001933 G1 box; other site 521097001934 GTP/Mg2+ binding site [chemical binding]; other site 521097001935 Switch I region; other site 521097001936 G2 box; other site 521097001937 G3 box; other site 521097001938 Switch II region; other site 521097001939 G4 box; other site 521097001940 G5 box; other site 521097001941 Nucleoside recognition; Region: Gate; pfam07670 521097001942 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 521097001943 Nucleoside recognition; Region: Gate; pfam07670 521097001944 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 521097001945 Malic enzyme, N-terminal domain; Region: malic; pfam00390 521097001946 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 521097001947 putative NAD(P) binding site [chemical binding]; other site 521097001948 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 521097001949 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001950 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097001951 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 521097001952 N-terminal plug; other site 521097001953 ligand-binding site [chemical binding]; other site 521097001954 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521097001955 FOG: CBS domain [General function prediction only]; Region: COG0517 521097001956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521097001957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521097001958 catalytic residues [active] 521097001959 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 521097001960 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 521097001961 dimer interface [polypeptide binding]; other site 521097001962 decamer (pentamer of dimers) interface [polypeptide binding]; other site 521097001963 catalytic triad [active] 521097001964 peroxidatic and resolving cysteines [active] 521097001965 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 521097001966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521097001967 binding surface 521097001968 TPR motif; other site 521097001969 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 521097001970 pantothenate kinase; Reviewed; Region: PRK13320 521097001971 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521097001972 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521097001973 FtsX-like permease family; Region: FtsX; pfam02687 521097001974 Fic family protein [Function unknown]; Region: COG3177 521097001975 Fic/DOC family; Region: Fic; pfam02661 521097001976 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 521097001977 Ribosome-binding factor A; Region: RBFA; pfam02033 521097001978 Protein of unknown function, DUF488; Region: DUF488; cl01246 521097001979 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 521097001980 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 521097001981 HEAT repeats; Region: HEAT_2; pfam13646 521097001982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097001983 TPR motif; other site 521097001984 binding surface 521097001985 TPR repeat; Region: TPR_11; pfam13414 521097001986 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097001987 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097001988 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 521097001989 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097001990 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097001991 SusD family; Region: SusD; pfam07980 521097001992 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521097001993 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 521097001994 transmembrane helices; other site 521097001995 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 521097001996 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521097001997 phosphodiesterase; Provisional; Region: PRK12704 521097001998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521097001999 Zn2+ binding site [ion binding]; other site 521097002000 Mg2+ binding site [ion binding]; other site 521097002001 Cell division protein ZapA; Region: ZapA; pfam05164 521097002002 rod shape-determining protein MreC; Provisional; Region: PRK13922 521097002003 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 521097002004 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 521097002005 putative ATP binding site [chemical binding]; other site 521097002006 putative substrate interface [chemical binding]; other site 521097002007 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 521097002008 hypothetical protein; Provisional; Region: PRK09936 521097002009 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 521097002010 PhoH-like protein; Region: PhoH; pfam02562 521097002011 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002012 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097002013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097002014 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 521097002015 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 521097002016 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 521097002017 Active Sites [active] 521097002018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521097002019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521097002020 catalytic residues [active] 521097002021 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 521097002022 META domain; Region: META; pfam03724 521097002023 recombinase A; Provisional; Region: recA; PRK09354 521097002024 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521097002025 hexamer interface [polypeptide binding]; other site 521097002026 Walker A motif; other site 521097002027 ATP binding site [chemical binding]; other site 521097002028 Walker B motif; other site 521097002029 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 521097002030 homodimer interface [polypeptide binding]; other site 521097002031 metal binding site [ion binding]; metal-binding site 521097002032 gliding motility associated protien GldN; Region: GldN; TIGR03523 521097002033 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 521097002034 GldM N-terminal domain; Region: GldM_N; pfam12081 521097002035 GldM C-terminal domain; Region: GldM_C; pfam12080 521097002036 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 521097002037 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 521097002038 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 521097002039 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 521097002040 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 521097002041 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521097002042 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 521097002043 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 521097002044 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521097002045 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521097002046 dimer interface [polypeptide binding]; other site 521097002047 anticodon binding site; other site 521097002048 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521097002049 homodimer interface [polypeptide binding]; other site 521097002050 motif 1; other site 521097002051 active site 521097002052 motif 2; other site 521097002053 GAD domain; Region: GAD; pfam02938 521097002054 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 521097002055 motif 3; other site 521097002056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 521097002057 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521097002058 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521097002059 active site 521097002060 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 521097002061 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521097002062 active site 521097002063 dimer interface [polypeptide binding]; other site 521097002064 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521097002065 dimer interface [polypeptide binding]; other site 521097002066 active site 521097002067 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 521097002068 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 521097002069 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 521097002070 cofactor binding site; other site 521097002071 DNA binding site [nucleotide binding] 521097002072 substrate interaction site [chemical binding]; other site 521097002073 putative peptidase; Provisional; Region: PRK11649 521097002074 Peptidase family M23; Region: Peptidase_M23; pfam01551 521097002075 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 521097002076 putative metal binding site [ion binding]; other site 521097002077 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521097002078 HSP70 interaction site [polypeptide binding]; other site 521097002079 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 521097002080 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 521097002081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521097002082 active site 521097002083 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 521097002084 ribonuclease R; Region: RNase_R; TIGR02063 521097002085 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 521097002086 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521097002087 RNB domain; Region: RNB; pfam00773 521097002088 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 521097002089 RNA binding site [nucleotide binding]; other site 521097002090 LysE type translocator; Region: LysE; cl00565 521097002091 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 521097002092 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521097002093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097002094 S-adenosylmethionine binding site [chemical binding]; other site 521097002095 maltose phosphorylase; Provisional; Region: PRK13807 521097002096 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 521097002097 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 521097002098 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 521097002099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 521097002100 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 521097002101 MutS domain I; Region: MutS_I; pfam01624 521097002102 MutS domain II; Region: MutS_II; pfam05188 521097002103 MutS domain III; Region: MutS_III; pfam05192 521097002104 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 521097002105 Walker A/P-loop; other site 521097002106 ATP binding site [chemical binding]; other site 521097002107 Q-loop/lid; other site 521097002108 ABC transporter signature motif; other site 521097002109 Walker B; other site 521097002110 D-loop; other site 521097002111 H-loop/switch region; other site 521097002112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521097002113 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521097002114 DNA binding residues [nucleotide binding] 521097002115 dimerization interface [polypeptide binding]; other site 521097002116 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 521097002117 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 521097002118 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 521097002119 FAD binding pocket [chemical binding]; other site 521097002120 conserved FAD binding motif [chemical binding]; other site 521097002121 phosphate binding motif [ion binding]; other site 521097002122 beta-alpha-beta structure motif; other site 521097002123 NAD binding pocket [chemical binding]; other site 521097002124 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 521097002125 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 521097002126 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521097002127 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 521097002128 dimer interface [polypeptide binding]; other site 521097002129 active site 521097002130 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 521097002131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097002132 putative substrate translocation pore; other site 521097002133 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 521097002134 active site 521097002135 catalytic residues [active] 521097002136 DNA binding site [nucleotide binding] 521097002137 Int/Topo IB signature motif; other site 521097002138 Helix-turn-helix domain; Region: HTH_17; pfam12728 521097002139 Phage-related protein [Function unknown]; Region: COG4695; cl01923 521097002140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 521097002141 non-specific DNA binding site [nucleotide binding]; other site 521097002142 salt bridge; other site 521097002143 sequence-specific DNA binding site [nucleotide binding]; other site 521097002144 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521097002145 Catalytic site [active] 521097002146 Helix-turn-helix domain; Region: HTH_17; pfam12728 521097002147 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 521097002148 AAA domain; Region: AAA_24; pfam13479 521097002149 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 521097002150 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 521097002151 AntA/AntB antirepressor; Region: AntA; cl01430 521097002152 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 521097002153 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521097002154 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097002155 ATP binding site [chemical binding]; other site 521097002156 putative Mg++ binding site [ion binding]; other site 521097002157 nucleotide binding region [chemical binding]; other site 521097002158 helicase superfamily c-terminal domain; Region: HELICc; smart00490 521097002159 ATP-binding site [chemical binding]; other site 521097002160 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 521097002161 DNA methylase; Region: N6_N4_Mtase; pfam01555 521097002162 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 521097002163 cofactor binding site; other site 521097002164 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 521097002165 DNA binding site [nucleotide binding] 521097002166 substrate interaction site [chemical binding]; other site 521097002167 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 521097002168 YopX protein; Region: YopX; pfam09643 521097002169 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 521097002170 putative metal binding site [ion binding]; other site 521097002171 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 521097002172 Phage terminase large subunit; Region: Terminase_3; cl12054 521097002173 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521097002174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 521097002175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521097002176 catalytic residue [active] 521097002177 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 521097002178 Uncharacterized conserved protein [Function unknown]; Region: COG2966 521097002179 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 521097002180 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 521097002181 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 521097002182 DNA primase; Validated; Region: dnaG; PRK05667 521097002183 CHC2 zinc finger; Region: zf-CHC2; pfam01807 521097002184 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521097002185 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521097002186 active site 521097002187 metal binding site [ion binding]; metal-binding site 521097002188 interdomain interaction site; other site 521097002189 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 521097002190 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 521097002191 gamma subunit interface [polypeptide binding]; other site 521097002192 LBP interface [polypeptide binding]; other site 521097002193 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 521097002194 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521097002195 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 521097002196 alpha subunit interaction interface [polypeptide binding]; other site 521097002197 Walker A motif; other site 521097002198 ATP binding site [chemical binding]; other site 521097002199 Walker B motif; other site 521097002200 inhibitor binding site; inhibition site 521097002201 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521097002202 Fic family protein [Function unknown]; Region: COG3177 521097002203 Fic/DOC family; Region: Fic; pfam02661 521097002204 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 521097002205 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 521097002206 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 521097002207 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 521097002208 hypothetical protein; Reviewed; Region: PRK00024 521097002209 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 521097002210 MPN+ (JAMM) motif; other site 521097002211 Zinc-binding site [ion binding]; other site 521097002212 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 521097002213 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521097002214 homodimer interface [polypeptide binding]; other site 521097002215 NAD binding pocket [chemical binding]; other site 521097002216 ATP binding pocket [chemical binding]; other site 521097002217 Mg binding site [ion binding]; other site 521097002218 active-site loop [active] 521097002219 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 521097002220 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 521097002221 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 521097002222 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 521097002223 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 521097002224 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 521097002225 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 521097002226 MgtC family; Region: MgtC; pfam02308 521097002227 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 521097002228 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 521097002229 NAD binding site [chemical binding]; other site 521097002230 homodimer interface [polypeptide binding]; other site 521097002231 active site 521097002232 substrate binding site [chemical binding]; other site 521097002233 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 521097002234 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 521097002235 SusE outer membrane protein; Region: SusE; pfam14292 521097002236 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 521097002237 starch binding site [chemical binding]; other site 521097002238 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 521097002239 starch binding site [chemical binding]; other site 521097002240 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097002241 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097002242 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002243 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002244 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097002245 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097002246 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521097002247 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521097002248 ligand binding site [chemical binding]; other site 521097002249 flexible hinge region; other site 521097002250 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 521097002251 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521097002252 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521097002253 ligand binding site [chemical binding]; other site 521097002254 flexible hinge region; other site 521097002255 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 521097002256 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 521097002257 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 521097002258 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097002259 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097002260 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 521097002261 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521097002262 metal ion-dependent adhesion site (MIDAS); other site 521097002263 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 521097002264 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 521097002265 threonine dehydratase; Provisional; Region: PRK08198 521097002266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 521097002267 tetramer interface [polypeptide binding]; other site 521097002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097002269 catalytic residue [active] 521097002270 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 521097002271 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097002272 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097002273 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097002274 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097002275 Conserved TM helix; Region: TM_helix; pfam05552 521097002276 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521097002277 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 521097002278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002279 active site 521097002280 HIGH motif; other site 521097002281 nucleotide binding site [chemical binding]; other site 521097002282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002283 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 521097002284 putative active site [active] 521097002285 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521097002286 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002287 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002289 active site 521097002290 KMSKS motif; other site 521097002291 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521097002292 tRNA binding surface [nucleotide binding]; other site 521097002293 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 521097002294 BRO family, N-terminal domain; Region: Bro-N; pfam02498 521097002295 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 521097002296 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 521097002297 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521097002298 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 521097002299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521097002300 inhibitor-cofactor binding pocket; inhibition site 521097002301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097002302 catalytic residue [active] 521097002303 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521097002304 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 521097002305 substrate binding site [chemical binding]; other site 521097002306 ATP binding site [chemical binding]; other site 521097002307 O-Antigen ligase; Region: Wzy_C; pfam04932 521097002308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097002309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521097002310 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 521097002311 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 521097002312 dimer interface [polypeptide binding]; other site 521097002313 Citrate synthase; Region: Citrate_synt; pfam00285 521097002314 active site 521097002315 citrylCoA binding site [chemical binding]; other site 521097002316 NADH binding [chemical binding]; other site 521097002317 cationic pore residues; other site 521097002318 oxalacetate/citrate binding site [chemical binding]; other site 521097002319 coenzyme A binding site [chemical binding]; other site 521097002320 catalytic triad [active] 521097002321 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 521097002322 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 521097002323 aconitate hydratase; Validated; Region: PRK07229 521097002324 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 521097002325 substrate binding site [chemical binding]; other site 521097002326 ligand binding site [chemical binding]; other site 521097002327 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 521097002328 substrate binding site [chemical binding]; other site 521097002329 pyruvate dehydrogenase; Provisional; Region: PRK09124 521097002330 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 521097002331 PYR/PP interface [polypeptide binding]; other site 521097002332 dimer interface [polypeptide binding]; other site 521097002333 tetramer interface [polypeptide binding]; other site 521097002334 TPP binding site [chemical binding]; other site 521097002335 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 521097002336 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 521097002337 TPP-binding site [chemical binding]; other site 521097002338 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 521097002339 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521097002340 hypothetical protein; Reviewed; Region: PRK12275 521097002341 four helix bundle protein; Region: TIGR02436 521097002342 Protein of unknown function (DUF502); Region: DUF502; cl01107 521097002343 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 521097002344 glutaminase; Provisional; Region: PRK00971 521097002345 Domain of unknown function DUF21; Region: DUF21; pfam01595 521097002346 gliding motility-associated protein GldE; Region: GldE; TIGR03520 521097002347 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521097002348 Transporter associated domain; Region: CorC_HlyC; smart01091 521097002349 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521097002350 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521097002351 dimer interface [polypeptide binding]; other site 521097002352 ssDNA binding site [nucleotide binding]; other site 521097002353 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521097002354 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 521097002355 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521097002356 minor groove reading motif; other site 521097002357 helix-hairpin-helix signature motif; other site 521097002358 substrate binding pocket [chemical binding]; other site 521097002359 active site 521097002360 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 521097002361 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 521097002362 DNA binding and oxoG recognition site [nucleotide binding] 521097002363 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 521097002364 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 521097002365 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 521097002366 putative active site [active] 521097002367 catalytic site [active] 521097002368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521097002369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097002370 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 521097002371 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 521097002372 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 521097002373 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 521097002374 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 521097002375 hypothetical protein; Reviewed; Region: PRK12275 521097002376 four helix bundle protein; Region: TIGR02436 521097002377 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 521097002378 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 521097002379 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 521097002380 active site 521097002381 catalytic site [active] 521097002382 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 521097002383 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 521097002384 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 521097002385 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 521097002386 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521097002387 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521097002388 active site 521097002389 dimer interface [polypeptide binding]; other site 521097002390 motif 1; other site 521097002391 motif 2; other site 521097002392 motif 3; other site 521097002393 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 521097002394 anticodon binding site; other site 521097002395 translation initiation factor IF-3; Region: infC; TIGR00168 521097002396 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521097002397 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521097002398 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 521097002399 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521097002400 23S rRNA binding site [nucleotide binding]; other site 521097002401 L21 binding site [polypeptide binding]; other site 521097002402 L13 binding site [polypeptide binding]; other site 521097002403 Part of AAA domain; Region: AAA_19; pfam13245 521097002404 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 521097002405 AAA domain; Region: AAA_12; pfam13087 521097002406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 521097002407 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 521097002408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097002409 S-adenosylmethionine binding site [chemical binding]; other site 521097002410 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 521097002411 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521097002412 HSP70 interaction site [polypeptide binding]; other site 521097002413 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 521097002414 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 521097002415 short chain dehydrogenase; Provisional; Region: PRK06180 521097002416 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 521097002417 NADP binding site [chemical binding]; other site 521097002418 active site 521097002419 steroid binding site; other site 521097002420 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 521097002421 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521097002422 Peptidase family M23; Region: Peptidase_M23; pfam01551 521097002423 Family of unknown function (DUF695); Region: DUF695; pfam05117 521097002424 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 521097002425 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 521097002426 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521097002427 DNA binding residues [nucleotide binding] 521097002428 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 521097002429 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521097002430 conserved cys residue [active] 521097002431 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 521097002432 Two component regulator propeller; Region: Reg_prop; pfam07494 521097002433 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 521097002434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097002435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097002436 dimer interface [polypeptide binding]; other site 521097002437 phosphorylation site [posttranslational modification] 521097002438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097002439 ATP binding site [chemical binding]; other site 521097002440 Mg2+ binding site [ion binding]; other site 521097002441 G-X-G motif; other site 521097002442 Response regulator receiver domain; Region: Response_reg; pfam00072 521097002443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097002444 active site 521097002445 phosphorylation site [posttranslational modification] 521097002446 intermolecular recognition site; other site 521097002447 dimerization interface [polypeptide binding]; other site 521097002448 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521097002449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097002450 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 521097002451 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521097002452 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521097002453 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521097002454 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 521097002455 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 521097002456 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 521097002457 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 521097002458 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 521097002459 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521097002460 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521097002461 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521097002462 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 521097002463 active site 521097002464 catalytic residues [active] 521097002465 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097002466 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097002467 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002468 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 521097002469 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097002470 starch binding outer membrane protein SusD; Region: SusD; cl17845 521097002471 SusD family; Region: SusD; pfam07980 521097002472 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002473 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002474 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 521097002475 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097002476 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521097002477 putative active site [active] 521097002478 catalytic residue [active] 521097002479 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 521097002480 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521097002481 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521097002482 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 521097002483 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 521097002484 MG2 domain; Region: A2M_N; pfam01835 521097002485 Alpha-2-macroglobulin family; Region: A2M; pfam00207 521097002486 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 521097002487 surface patch; other site 521097002488 thioester region; other site 521097002489 specificity defining residues; other site 521097002490 RecX family; Region: RecX; pfam02631 521097002491 Dihydroneopterin aldolase; Region: FolB; pfam02152 521097002492 active site 521097002493 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 521097002494 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097002495 active site 521097002496 catalytic triad [active] 521097002497 oxyanion hole [active] 521097002498 Domain of unknown function (DUF303); Region: DUF303; pfam03629 521097002499 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 521097002500 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097002501 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097002502 ligand binding site [chemical binding]; other site 521097002503 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097002504 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 521097002505 homodimer interface [polypeptide binding]; other site 521097002506 catalytic residues [active] 521097002507 NAD binding site [chemical binding]; other site 521097002508 substrate binding pocket [chemical binding]; other site 521097002509 flexible flap; other site 521097002510 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097002511 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097002512 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 521097002513 AMP binding site [chemical binding]; other site 521097002514 metal binding site [ion binding]; metal-binding site 521097002515 active site 521097002516 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 521097002517 active site 521097002518 hydrophilic channel; other site 521097002519 dimerization interface [polypeptide binding]; other site 521097002520 catalytic residues [active] 521097002521 active site lid [active] 521097002522 NifU-like domain; Region: NifU; cl00484 521097002523 Domain of unknown function DUF59; Region: DUF59; pfam01883 521097002524 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 521097002525 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 521097002526 Walker A motif; other site 521097002527 methionine sulfoxide reductase A; Provisional; Region: PRK14054 521097002528 methionine sulfoxide reductase B; Provisional; Region: PRK00222 521097002529 SelR domain; Region: SelR; pfam01641 521097002530 PQQ-like domain; Region: PQQ_2; pfam13360 521097002531 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 521097002532 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 521097002533 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 521097002534 DNA binding residues [nucleotide binding] 521097002535 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 521097002536 active sites [active] 521097002537 tetramer interface [polypeptide binding]; other site 521097002538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521097002539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097002540 NAD(P) binding site [chemical binding]; other site 521097002541 active site 521097002542 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 521097002543 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 521097002544 Prephenate dehydratase; Region: PDT; pfam00800 521097002545 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 521097002546 putative L-Phe binding site [chemical binding]; other site 521097002547 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 521097002548 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521097002549 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521097002550 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 521097002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097002552 putative substrate translocation pore; other site 521097002553 POT family; Region: PTR2; cl17359 521097002554 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 521097002555 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 521097002556 domain interfaces; other site 521097002557 active site 521097002558 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 521097002559 putative carbohydrate kinase; Provisional; Region: PRK10565 521097002560 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 521097002561 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 521097002562 putative substrate binding site [chemical binding]; other site 521097002563 putative ATP binding site [chemical binding]; other site 521097002564 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 521097002565 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 521097002566 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097002567 starch binding outer membrane protein SusD; Region: SusD; cl17845 521097002568 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002569 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002570 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097002571 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097002572 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 521097002573 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 521097002574 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 521097002575 FeoA domain; Region: FeoA; pfam04023 521097002576 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 521097002577 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 521097002578 G1 box; other site 521097002579 GTP/Mg2+ binding site [chemical binding]; other site 521097002580 Switch I region; other site 521097002581 G2 box; other site 521097002582 G3 box; other site 521097002583 Switch II region; other site 521097002584 G4 box; other site 521097002585 G5 box; other site 521097002586 Nucleoside recognition; Region: Gate; pfam07670 521097002587 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 521097002588 Nucleoside recognition; Region: Gate; pfam07670 521097002589 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 521097002590 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 521097002591 active site 521097002592 nucleophile elbow; other site 521097002593 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 521097002594 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 521097002595 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521097002596 Beta-lactamase; Region: Beta-lactamase; pfam00144 521097002597 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 521097002598 active site 521097002599 catalytic site [active] 521097002600 substrate binding site [chemical binding]; other site 521097002601 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521097002602 Glycoprotease family; Region: Peptidase_M22; pfam00814 521097002603 Predicted methyltransferases [General function prediction only]; Region: COG0313 521097002604 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 521097002605 putative SAM binding site [chemical binding]; other site 521097002606 putative homodimer interface [polypeptide binding]; other site 521097002607 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 521097002608 putative active site [active] 521097002609 catalytic residue [active] 521097002610 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 521097002611 AAA domain; Region: AAA_28; pfam13521 521097002612 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 521097002613 Domain of unknown function DUF77; Region: DUF77; cl00307 521097002614 DNA polymerase I; Provisional; Region: PRK05755 521097002615 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521097002616 active site 521097002617 metal binding site 1 [ion binding]; metal-binding site 521097002618 putative 5' ssDNA interaction site; other site 521097002619 metal binding site 3; metal-binding site 521097002620 metal binding site 2 [ion binding]; metal-binding site 521097002621 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521097002622 putative DNA binding site [nucleotide binding]; other site 521097002623 putative metal binding site [ion binding]; other site 521097002624 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 521097002625 active site 521097002626 catalytic site [active] 521097002627 substrate binding site [chemical binding]; other site 521097002628 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521097002629 active site 521097002630 DNA binding site [nucleotide binding] 521097002631 catalytic site [active] 521097002632 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521097002633 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 521097002634 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097002635 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521097002636 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521097002637 Walker A/P-loop; other site 521097002638 ATP binding site [chemical binding]; other site 521097002639 Q-loop/lid; other site 521097002640 ABC transporter signature motif; other site 521097002641 Walker B; other site 521097002642 D-loop; other site 521097002643 H-loop/switch region; other site 521097002644 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002645 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 521097002646 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 521097002647 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 521097002648 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 521097002649 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 521097002650 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 521097002651 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 521097002652 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521097002653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 521097002654 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 521097002655 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 521097002656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097002657 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097002658 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521097002659 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 521097002660 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 521097002661 NAD(P) binding site [chemical binding]; other site 521097002662 homodimer interface [polypeptide binding]; other site 521097002663 substrate binding site [chemical binding]; other site 521097002664 active site 521097002665 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 521097002666 WxcM-like, C-terminal; Region: FdtA; pfam05523 521097002667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097002668 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 521097002669 NAD(P) binding site [chemical binding]; other site 521097002670 active site 521097002671 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 521097002672 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 521097002673 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 521097002674 active site 521097002675 homodimer interface [polypeptide binding]; other site 521097002676 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 521097002677 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 521097002678 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 521097002679 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 521097002680 Flavodoxin; Region: Flavodoxin_1; pfam00258 521097002681 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 521097002682 FAD binding pocket [chemical binding]; other site 521097002683 conserved FAD binding motif [chemical binding]; other site 521097002684 phosphate binding motif [ion binding]; other site 521097002685 beta-alpha-beta structure motif; other site 521097002686 NAD binding pocket [chemical binding]; other site 521097002687 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097002688 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097002689 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521097002690 putative catalytic site [active] 521097002691 putative metal binding site [ion binding]; other site 521097002692 putative phosphate binding site [ion binding]; other site 521097002693 Transglycosylase; Region: Transgly; pfam00912 521097002694 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 521097002695 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002696 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002697 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097002698 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097002699 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097002700 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097002701 SusD family; Region: SusD; pfam07980 521097002702 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521097002703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521097002704 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521097002705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 521097002706 Putative glucoamylase; Region: Glycoamylase; pfam10091 521097002707 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 521097002708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 521097002709 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002710 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002711 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097002712 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097002713 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097002714 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 521097002715 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 521097002716 active site 521097002717 catalytic residues [active] 521097002718 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 521097002719 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 521097002720 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 521097002721 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 521097002722 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002723 active site 521097002724 HIGH motif; other site 521097002725 nucleotide binding site [chemical binding]; other site 521097002726 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097002727 active site 521097002728 KMSKS motif; other site 521097002729 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 521097002730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 521097002731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 521097002732 DNA binding residues [nucleotide binding] 521097002733 dimerization interface [polypeptide binding]; other site 521097002734 CAAX protease self-immunity; Region: Abi; pfam02517 521097002735 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 521097002736 active site clefts [active] 521097002737 zinc binding site [ion binding]; other site 521097002738 dimer interface [polypeptide binding]; other site 521097002739 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097002740 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097002741 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097002742 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097002743 starch binding outer membrane protein SusD; Region: SusD; cl17845 521097002744 SusD family; Region: SusD; pfam07980 521097002745 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 521097002746 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 521097002747 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 521097002748 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 521097002749 putative tRNA-binding site [nucleotide binding]; other site 521097002750 B3/4 domain; Region: B3_4; pfam03483 521097002751 tRNA synthetase B5 domain; Region: B5; pfam03484 521097002752 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521097002753 dimer interface [polypeptide binding]; other site 521097002754 motif 1; other site 521097002755 motif 3; other site 521097002756 motif 2; other site 521097002757 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 521097002758 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521097002759 S17 interaction site [polypeptide binding]; other site 521097002760 S8 interaction site; other site 521097002761 16S rRNA interaction site [nucleotide binding]; other site 521097002762 streptomycin interaction site [chemical binding]; other site 521097002763 23S rRNA interaction site [nucleotide binding]; other site 521097002764 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521097002765 30S ribosomal protein S7; Validated; Region: PRK05302 521097002766 elongation factor G; Reviewed; Region: PRK12739 521097002767 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521097002768 G1 box; other site 521097002769 putative GEF interaction site [polypeptide binding]; other site 521097002770 GTP/Mg2+ binding site [chemical binding]; other site 521097002771 Switch I region; other site 521097002772 G2 box; other site 521097002773 G3 box; other site 521097002774 Switch II region; other site 521097002775 G4 box; other site 521097002776 G5 box; other site 521097002777 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521097002778 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521097002779 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521097002780 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 521097002781 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 521097002782 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 521097002783 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 521097002784 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521097002785 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521097002786 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521097002787 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 521097002788 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521097002789 putative translocon binding site; other site 521097002790 protein-rRNA interface [nucleotide binding]; other site 521097002791 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521097002792 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521097002793 G-X-X-G motif; other site 521097002794 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521097002795 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521097002796 23S rRNA interface [nucleotide binding]; other site 521097002797 5S rRNA interface [nucleotide binding]; other site 521097002798 putative antibiotic binding site [chemical binding]; other site 521097002799 L25 interface [polypeptide binding]; other site 521097002800 L27 interface [polypeptide binding]; other site 521097002801 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521097002802 23S rRNA interface [nucleotide binding]; other site 521097002803 putative translocon interaction site; other site 521097002804 signal recognition particle (SRP54) interaction site; other site 521097002805 L23 interface [polypeptide binding]; other site 521097002806 trigger factor interaction site; other site 521097002807 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 521097002808 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 521097002809 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521097002810 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 521097002811 RNA binding site [nucleotide binding]; other site 521097002812 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521097002813 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521097002814 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521097002815 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 521097002816 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 521097002817 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521097002818 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521097002819 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521097002820 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521097002821 23S rRNA interface [nucleotide binding]; other site 521097002822 L21e interface [polypeptide binding]; other site 521097002823 5S rRNA interface [nucleotide binding]; other site 521097002824 L27 interface [polypeptide binding]; other site 521097002825 L5 interface [polypeptide binding]; other site 521097002826 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 521097002827 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521097002828 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521097002829 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 521097002830 23S rRNA binding site [nucleotide binding]; other site 521097002831 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 521097002832 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521097002833 SecY translocase; Region: SecY; pfam00344 521097002834 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521097002835 rRNA binding site [nucleotide binding]; other site 521097002836 predicted 30S ribosome binding site; other site 521097002837 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 521097002838 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 521097002839 30S ribosomal protein S13; Region: bact_S13; TIGR03631 521097002840 30S ribosomal protein S11; Validated; Region: PRK05309 521097002841 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521097002842 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521097002843 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521097002844 RNA binding surface [nucleotide binding]; other site 521097002845 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521097002846 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521097002847 alphaNTD homodimer interface [polypeptide binding]; other site 521097002848 alphaNTD - beta interaction site [polypeptide binding]; other site 521097002849 alphaNTD - beta' interaction site [polypeptide binding]; other site 521097002850 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521097002851 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 521097002852 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 521097002853 recombination protein F; Reviewed; Region: recF; PRK00064 521097002854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097002855 Walker A/P-loop; other site 521097002856 ATP binding site [chemical binding]; other site 521097002857 Q-loop/lid; other site 521097002858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097002859 ABC transporter signature motif; other site 521097002860 Walker B; other site 521097002861 D-loop; other site 521097002862 H-loop/switch region; other site 521097002863 Putative addiction module component; Region: Unstab_antitox; cl09921 521097002864 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 521097002865 O-Antigen ligase; Region: Wzy_C; pfam04932 521097002866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097002867 binding surface 521097002868 TPR motif; other site 521097002869 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 521097002870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097002871 active site 521097002872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097002873 HAMP domain; Region: HAMP; pfam00672 521097002874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097002875 dimer interface [polypeptide binding]; other site 521097002876 phosphorylation site [posttranslational modification] 521097002877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097002878 ATP binding site [chemical binding]; other site 521097002879 Mg2+ binding site [ion binding]; other site 521097002880 G-X-G motif; other site 521097002881 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 521097002882 NlpE N-terminal domain; Region: NlpE; pfam04170 521097002883 Bifunctional nuclease; Region: DNase-RNase; pfam02577 521097002884 UvrB/uvrC motif; Region: UVR; pfam02151 521097002885 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 521097002886 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 521097002887 Nucleoside recognition; Region: Gate; pfam07670 521097002888 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 521097002889 hypothetical protein; Provisional; Region: PRK08201 521097002890 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 521097002891 metal binding site [ion binding]; metal-binding site 521097002892 putative dimer interface [polypeptide binding]; other site 521097002893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 521097002894 ATP phosphoribosyltransferase; Region: HisG; cl15266 521097002895 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 521097002896 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 521097002897 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 521097002898 active site 521097002899 Fn3 associated; Region: Fn3_assoc; pfam13287 521097002900 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521097002901 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 521097002902 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 521097002903 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521097002904 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 521097002905 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 521097002906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097002907 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521097002908 Walker A motif; other site 521097002909 ATP binding site [chemical binding]; other site 521097002910 Walker B motif; other site 521097002911 arginine finger; other site 521097002912 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521097002913 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 521097002914 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 521097002915 putative active site [active] 521097002916 catalytic site [active] 521097002917 putative metal binding site [ion binding]; other site 521097002918 oligomer interface [polypeptide binding]; other site 521097002919 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 521097002920 dimer interface [polypeptide binding]; other site 521097002921 putative radical transfer pathway; other site 521097002922 diiron center [ion binding]; other site 521097002923 tyrosyl radical; other site 521097002924 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 521097002925 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 521097002926 NADP binding site [chemical binding]; other site 521097002927 active site 521097002928 putative substrate binding site [chemical binding]; other site 521097002929 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 521097002930 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 521097002931 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 521097002932 Peptidase family M48; Region: Peptidase_M48; cl12018 521097002933 elongation factor Tu; Reviewed; Region: PRK12735 521097002934 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521097002935 G1 box; other site 521097002936 GEF interaction site [polypeptide binding]; other site 521097002937 GTP/Mg2+ binding site [chemical binding]; other site 521097002938 Switch I region; other site 521097002939 G2 box; other site 521097002940 G3 box; other site 521097002941 Switch II region; other site 521097002942 G4 box; other site 521097002943 G5 box; other site 521097002944 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521097002945 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521097002946 Antibiotic Binding Site [chemical binding]; other site 521097002947 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 521097002948 S-ribosylhomocysteinase; Provisional; Region: PRK02260 521097002949 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521097002950 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521097002951 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 521097002952 active site 521097002953 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 521097002954 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521097002955 Walker A/P-loop; other site 521097002956 ATP binding site [chemical binding]; other site 521097002957 Q-loop/lid; other site 521097002958 ABC transporter signature motif; other site 521097002959 Walker B; other site 521097002960 D-loop; other site 521097002961 H-loop/switch region; other site 521097002962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097002963 Response regulator receiver domain; Region: Response_reg; pfam00072 521097002964 active site 521097002965 phosphorylation site [posttranslational modification] 521097002966 intermolecular recognition site; other site 521097002967 dimerization interface [polypeptide binding]; other site 521097002968 LytTr DNA-binding domain; Region: LytTR; smart00850 521097002969 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 521097002970 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 521097002971 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521097002972 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521097002973 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521097002974 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521097002975 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 521097002976 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 521097002977 tandem repeat interface [polypeptide binding]; other site 521097002978 oligomer interface [polypeptide binding]; other site 521097002979 active site residues [active] 521097002980 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 521097002981 tandem repeat interface [polypeptide binding]; other site 521097002982 oligomer interface [polypeptide binding]; other site 521097002983 active site residues [active] 521097002984 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521097002985 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 521097002986 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521097002987 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 521097002988 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 521097002989 Active Sites [active] 521097002990 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 521097002991 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 521097002992 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 521097002993 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521097002994 FeoA domain; Region: FeoA; pfam04023 521097002995 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 521097002996 Sporulation related domain; Region: SPOR; pfam05036 521097002997 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 521097002998 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521097002999 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 521097003000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097003001 NAD(P) binding site [chemical binding]; other site 521097003002 active site 521097003003 Predicted membrane protein [Function unknown]; Region: COG2510 521097003004 FeS assembly ATPase SufC; Region: sufC; TIGR01978 521097003005 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 521097003006 Walker A/P-loop; other site 521097003007 ATP binding site [chemical binding]; other site 521097003008 Q-loop/lid; other site 521097003009 ABC transporter signature motif; other site 521097003010 Walker B; other site 521097003011 D-loop; other site 521097003012 H-loop/switch region; other site 521097003013 FeS assembly protein SufD; Region: sufD; TIGR01981 521097003014 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 521097003015 adenylosuccinate lyase; Provisional; Region: PRK09285 521097003016 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 521097003017 tetramer interface [polypeptide binding]; other site 521097003018 active site 521097003019 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 521097003020 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 521097003021 DNA polymerase III subunit delta'; Validated; Region: PRK08485 521097003022 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 521097003023 Zn binding site [ion binding]; other site 521097003024 thymidylate synthase; Reviewed; Region: thyA; PRK01827 521097003025 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 521097003026 dimerization interface [polypeptide binding]; other site 521097003027 active site 521097003028 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 521097003029 26S proteasome subunit RPN7; Region: RPN7; pfam10602 521097003030 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 521097003031 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 521097003032 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 521097003033 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 521097003034 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 521097003035 FOG: PKD repeat [General function prediction only]; Region: COG3291 521097003036 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 521097003037 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521097003038 translation initiation factor IF-2; Region: IF-2; TIGR00487 521097003039 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521097003040 G1 box; other site 521097003041 putative GEF interaction site [polypeptide binding]; other site 521097003042 GTP/Mg2+ binding site [chemical binding]; other site 521097003043 Switch I region; other site 521097003044 G2 box; other site 521097003045 G3 box; other site 521097003046 Switch II region; other site 521097003047 G4 box; other site 521097003048 G5 box; other site 521097003049 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521097003050 Translation-initiation factor 2; Region: IF-2; pfam11987 521097003051 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521097003052 transcription termination factor NusA; Region: NusA; TIGR01953 521097003053 NusA N-terminal domain; Region: NusA_N; pfam08529 521097003054 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521097003055 RNA binding site [nucleotide binding]; other site 521097003056 homodimer interface [polypeptide binding]; other site 521097003057 NusA-like KH domain; Region: KH_5; pfam13184 521097003058 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521097003059 G-X-X-G motif; other site 521097003060 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 521097003061 hypothetical protein; Validated; Region: PRK02001 521097003062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 521097003063 heptamer interface [polypeptide binding]; other site 521097003064 Sm1 motif; other site 521097003065 hexamer interface [polypeptide binding]; other site 521097003066 RNA binding site [nucleotide binding]; other site 521097003067 Sm2 motif; other site 521097003068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521097003069 Ligand Binding Site [chemical binding]; other site 521097003070 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 521097003071 Ligand Binding Site [chemical binding]; other site 521097003072 Isochorismatase family; Region: Isochorismatase; pfam00857 521097003073 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 521097003074 catalytic triad [active] 521097003075 dimer interface [polypeptide binding]; other site 521097003076 conserved cis-peptide bond; other site 521097003077 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 521097003078 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 521097003079 active site 521097003080 Zn binding site [ion binding]; other site 521097003081 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 521097003082 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 521097003083 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 521097003084 dimer interface [polypeptide binding]; other site 521097003085 allosteric magnesium binding site [ion binding]; other site 521097003086 active site 521097003087 aspartate-rich active site metal binding site; other site 521097003088 Schiff base residues; other site 521097003089 Cytochrome c; Region: Cytochrom_C; pfam00034 521097003090 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 521097003091 Domain of unknown function DUF21; Region: DUF21; pfam01595 521097003092 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521097003093 Transporter associated domain; Region: CorC_HlyC; smart01091 521097003094 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 521097003095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 521097003096 dimerization interface [polypeptide binding]; other site 521097003097 ATP binding site [chemical binding]; other site 521097003098 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 521097003099 dimerization interface [polypeptide binding]; other site 521097003100 ATP binding site [chemical binding]; other site 521097003101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 521097003102 putative active site [active] 521097003103 catalytic triad [active] 521097003104 Fic/DOC family; Region: Fic; pfam02661 521097003105 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 521097003106 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521097003107 GIY-YIG motif/motif A; other site 521097003108 active site 521097003109 catalytic site [active] 521097003110 putative DNA binding site [nucleotide binding]; other site 521097003111 metal binding site [ion binding]; metal-binding site 521097003112 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521097003113 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 521097003114 DNA binding site [nucleotide binding] 521097003115 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 521097003116 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097003117 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097003118 ligand binding site [chemical binding]; other site 521097003119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521097003120 Glycogen synthase; Region: Glycogen_syn; pfam05693 521097003121 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 521097003122 putative homodimer interface [polypeptide binding]; other site 521097003123 putative active site pocket [active] 521097003124 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 521097003125 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097003126 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 521097003127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521097003128 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521097003129 DNA binding residues [nucleotide binding] 521097003130 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 521097003131 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003132 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097003133 Helix-turn-helix domain; Region: HTH_18; pfam12833 521097003134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097003135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 521097003136 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 521097003137 active site 521097003138 catalytic tetrad [active] 521097003139 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 521097003140 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 521097003141 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 521097003142 DNA binding residues [nucleotide binding] 521097003143 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 521097003144 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 521097003145 classical (c) SDRs; Region: SDR_c; cd05233 521097003146 NAD(P) binding site [chemical binding]; other site 521097003147 active site 521097003148 Helix-turn-helix domain; Region: HTH_18; pfam12833 521097003149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097003150 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003151 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097003152 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097003153 cellulose synthase A; Region: PLN02195 521097003154 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 521097003155 NADH(P)-binding; Region: NAD_binding_10; pfam13460 521097003156 NAD(P) binding site [chemical binding]; other site 521097003157 putative active site [active] 521097003158 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 521097003159 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097003160 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097003161 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 521097003162 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 521097003163 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 521097003164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097003165 NAD(P) binding site [chemical binding]; other site 521097003166 active site 521097003167 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 521097003168 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 521097003169 active site 521097003170 acyl carrier protein; Provisional; Region: acpP; PRK00982 521097003171 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 521097003172 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 521097003173 dimer interface [polypeptide binding]; other site 521097003174 active site 521097003175 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521097003176 dimerization interface [polypeptide binding]; other site 521097003177 active site 521097003178 metal binding site [ion binding]; metal-binding site 521097003179 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 521097003180 active site 521097003181 metal binding site [ion binding]; metal-binding site 521097003182 homotetramer interface [polypeptide binding]; other site 521097003183 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 521097003184 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521097003185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097003186 FeS/SAM binding site; other site 521097003187 TRAM domain; Region: TRAM; pfam01938 521097003188 Phosphoglycerate kinase; Region: PGK; pfam00162 521097003189 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521097003190 substrate binding site [chemical binding]; other site 521097003191 hinge regions; other site 521097003192 ADP binding site [chemical binding]; other site 521097003193 catalytic site [active] 521097003194 Phosphate transporter family; Region: PHO4; pfam01384 521097003195 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521097003196 Sulfatase; Region: Sulfatase; pfam00884 521097003197 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 521097003198 muropeptide transporter; Validated; Region: ampG; cl17669 521097003199 thymidine kinase; Provisional; Region: PRK04296 521097003200 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 521097003201 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 521097003202 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 521097003203 TPP-binding site; other site 521097003204 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521097003205 PYR/PP interface [polypeptide binding]; other site 521097003206 dimer interface [polypeptide binding]; other site 521097003207 TPP binding site [chemical binding]; other site 521097003208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521097003209 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 521097003210 ferrochelatase; Reviewed; Region: hemH; PRK00035 521097003211 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 521097003212 C-terminal domain interface [polypeptide binding]; other site 521097003213 active site 521097003214 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 521097003215 active site 521097003216 N-terminal domain interface [polypeptide binding]; other site 521097003217 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 521097003218 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 521097003219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521097003220 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521097003221 HYR domain; Region: HYR; pfam02494 521097003222 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 521097003223 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097003224 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 521097003225 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 521097003226 Hemerythrin-like domain; Region: Hr-like; cd12108 521097003227 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521097003228 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521097003229 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521097003230 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521097003231 Virulence protein [General function prediction only]; Region: COG3943 521097003232 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 521097003233 Uncharacterized conserved protein [Function unknown]; Region: COG2968 521097003234 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 521097003235 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097003236 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003237 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097003238 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 521097003239 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097003240 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 521097003241 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 521097003242 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 521097003243 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 521097003244 active site 521097003245 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 521097003246 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 521097003247 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 521097003248 Sulfatase; Region: Sulfatase; pfam00884 521097003249 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521097003250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521097003251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521097003252 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097003253 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 521097003254 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 521097003255 catalytic residue [active] 521097003256 putative FPP diphosphate binding site; other site 521097003257 putative FPP binding hydrophobic cleft; other site 521097003258 dimer interface [polypeptide binding]; other site 521097003259 putative IPP diphosphate binding site; other site 521097003260 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 521097003261 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521097003262 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521097003263 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 521097003264 Surface antigen; Region: Bac_surface_Ag; pfam01103 521097003265 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 521097003266 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 521097003267 periplasmic chaperone; Provisional; Region: PRK10780 521097003268 glutamate racemase; Provisional; Region: PRK00865 521097003269 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 521097003270 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 521097003271 N-acetyl-D-glucosamine binding site [chemical binding]; other site 521097003272 catalytic residue [active] 521097003273 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 521097003274 Peptidase family M1; Region: Peptidase_M1; pfam01433 521097003275 Zn binding site [ion binding]; other site 521097003276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521097003277 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521097003278 Fic/DOC family; Region: Fic; cl00960 521097003279 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 521097003280 GTP-binding protein Der; Reviewed; Region: PRK00093 521097003281 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 521097003282 G1 box; other site 521097003283 GTP/Mg2+ binding site [chemical binding]; other site 521097003284 Switch I region; other site 521097003285 G2 box; other site 521097003286 Switch II region; other site 521097003287 G3 box; other site 521097003288 G4 box; other site 521097003289 G5 box; other site 521097003290 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521097003291 G1 box; other site 521097003292 GTP/Mg2+ binding site [chemical binding]; other site 521097003293 Switch I region; other site 521097003294 G2 box; other site 521097003295 G3 box; other site 521097003296 Switch II region; other site 521097003297 G4 box; other site 521097003298 G5 box; other site 521097003299 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 521097003300 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521097003301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521097003302 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 521097003303 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 521097003304 active site 521097003305 (T/H)XGH motif; other site 521097003306 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 521097003307 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 521097003308 glutaminase active site [active] 521097003309 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521097003310 dimer interface [polypeptide binding]; other site 521097003311 active site 521097003312 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 521097003313 dimer interface [polypeptide binding]; other site 521097003314 active site 521097003315 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 521097003316 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 521097003317 acyl-activating enzyme (AAE) consensus motif; other site 521097003318 putative AMP binding site [chemical binding]; other site 521097003319 putative active site [active] 521097003320 putative CoA binding site [chemical binding]; other site 521097003321 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 521097003322 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 521097003323 active site 521097003324 Riboflavin kinase; Region: Flavokinase; pfam01687 521097003325 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 521097003326 catalytic motif [active] 521097003327 Zn binding site [ion binding]; other site 521097003328 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 521097003329 active site 521097003330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521097003331 putative active site [active] 521097003332 PAS fold; Region: PAS_3; pfam08447 521097003333 heme pocket [chemical binding]; other site 521097003334 glycyl-tRNA synthetase; Provisional; Region: PRK04173 521097003335 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521097003336 motif 1; other site 521097003337 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 521097003338 active site 521097003339 motif 2; other site 521097003340 motif 3; other site 521097003341 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 521097003342 anticodon binding site; other site 521097003343 comF family protein; Region: comF; TIGR00201 521097003344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097003345 active site 521097003346 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 521097003347 Yqey-like protein; Region: YqeY; pfam09424 521097003348 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 521097003349 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 521097003350 tetrameric interface [polypeptide binding]; other site 521097003351 activator binding site; other site 521097003352 NADP binding site [chemical binding]; other site 521097003353 substrate binding site [chemical binding]; other site 521097003354 catalytic residues [active] 521097003355 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097003356 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003357 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097003358 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 521097003359 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097003360 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 521097003361 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 521097003362 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521097003363 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 521097003364 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 521097003365 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521097003366 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 521097003367 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 521097003368 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 521097003369 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 521097003370 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 521097003371 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 521097003372 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 521097003373 TM2 domain; Region: TM2; pfam05154 521097003374 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 521097003375 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 521097003376 Maf-like protein; Region: Maf; pfam02545 521097003377 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 521097003378 active site 521097003379 dimer interface [polypeptide binding]; other site 521097003380 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521097003381 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521097003382 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521097003383 rod shape-determining protein MreC; Provisional; Region: PRK13922 521097003384 rod shape-determining protein MreC; Region: MreC; pfam04085 521097003385 rod shape-determining protein MreB; Provisional; Region: PRK13927 521097003386 MreB and similar proteins; Region: MreB_like; cd10225 521097003387 nucleotide binding site [chemical binding]; other site 521097003388 Mg binding site [ion binding]; other site 521097003389 putative protofilament interaction site [polypeptide binding]; other site 521097003390 RodZ interaction site [polypeptide binding]; other site 521097003391 cytidylate kinase; Provisional; Region: cmk; PRK00023 521097003392 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521097003393 CMP-binding site; other site 521097003394 The sites determining sugar specificity; other site 521097003395 biotin synthase; Region: bioB; TIGR00433 521097003396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097003397 FeS/SAM binding site; other site 521097003398 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 521097003399 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 521097003400 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 521097003401 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 521097003402 trimer interface [polypeptide binding]; other site 521097003403 putative metal binding site [ion binding]; other site 521097003404 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 521097003405 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 521097003406 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 521097003407 active site 521097003408 substrate binding site [chemical binding]; other site 521097003409 trimer interface [polypeptide binding]; other site 521097003410 CoA binding site [chemical binding]; other site 521097003411 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521097003412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097003413 active site 521097003414 HIGH motif; other site 521097003415 nucleotide binding site [chemical binding]; other site 521097003416 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521097003417 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521097003418 active site 521097003419 KMSKS motif; other site 521097003420 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521097003421 tRNA binding surface [nucleotide binding]; other site 521097003422 anticodon binding site; other site 521097003423 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521097003424 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 521097003425 active site 521097003426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521097003427 exonuclease subunit SbcD; Provisional; Region: PRK10966 521097003428 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 521097003429 active site 521097003430 metal binding site [ion binding]; metal-binding site 521097003431 DNA binding site [nucleotide binding] 521097003432 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 521097003433 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 521097003434 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 521097003435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521097003436 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 521097003437 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 521097003438 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 521097003439 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 521097003440 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 521097003441 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 521097003442 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 521097003443 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 521097003444 active site 521097003445 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 521097003446 molybdopterin cofactor binding site; other site 521097003447 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 521097003448 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 521097003449 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 521097003450 heme-binding residues [chemical binding]; other site 521097003451 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 521097003452 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521097003453 CoA-binding site [chemical binding]; other site 521097003454 ATP-binding [chemical binding]; other site 521097003455 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 521097003456 prephenate dehydrogenase; Validated; Region: PRK08507 521097003457 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 521097003458 Lamin Tail Domain; Region: LTD; pfam00932 521097003459 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 521097003460 putative active site [active] 521097003461 putative metal binding residues [ion binding]; other site 521097003462 signature motif; other site 521097003463 putative dimer interface [polypeptide binding]; other site 521097003464 putative phosphate binding site [ion binding]; other site 521097003465 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 521097003466 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521097003467 transmembrane helices; other site 521097003468 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 521097003469 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 521097003470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097003471 putative substrate translocation pore; other site 521097003472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097003473 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 521097003474 recombination factor protein RarA; Reviewed; Region: PRK13342 521097003475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097003476 Walker A motif; other site 521097003477 ATP binding site [chemical binding]; other site 521097003478 Walker B motif; other site 521097003479 arginine finger; other site 521097003480 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 521097003481 excinuclease ABC subunit B; Provisional; Region: PRK05298 521097003482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097003483 ATP binding site [chemical binding]; other site 521097003484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097003485 nucleotide binding region [chemical binding]; other site 521097003486 ATP-binding site [chemical binding]; other site 521097003487 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521097003488 UvrB/uvrC motif; Region: UVR; pfam02151 521097003489 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097003490 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521097003491 active site 521097003492 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 521097003493 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521097003494 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 521097003495 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 521097003496 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 521097003497 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 521097003498 Sporulation related domain; Region: SPOR; cl10051 521097003499 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097003500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521097003501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097003502 active site 521097003503 phosphorylation site [posttranslational modification] 521097003504 intermolecular recognition site; other site 521097003505 dimerization interface [polypeptide binding]; other site 521097003506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521097003507 DNA binding site [nucleotide binding] 521097003508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097003509 dimer interface [polypeptide binding]; other site 521097003510 phosphorylation site [posttranslational modification] 521097003511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097003512 ATP binding site [chemical binding]; other site 521097003513 Mg2+ binding site [ion binding]; other site 521097003514 G-X-G motif; other site 521097003515 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 521097003516 putative active site [active] 521097003517 putative catalytic site [active] 521097003518 putative DNA binding site [nucleotide binding]; other site 521097003519 putative phosphate binding site [ion binding]; other site 521097003520 metal binding site A [ion binding]; metal-binding site 521097003521 putative AP binding site [nucleotide binding]; other site 521097003522 putative metal binding site B [ion binding]; other site 521097003523 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 521097003524 intersubunit interface [polypeptide binding]; other site 521097003525 active site 521097003526 catalytic residue [active] 521097003527 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 521097003528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097003529 ATP binding site [chemical binding]; other site 521097003530 Mg2+ binding site [ion binding]; other site 521097003531 G-X-G motif; other site 521097003532 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521097003533 anchoring element; other site 521097003534 dimer interface [polypeptide binding]; other site 521097003535 ATP binding site [chemical binding]; other site 521097003536 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 521097003537 active site 521097003538 putative metal-binding site [ion binding]; other site 521097003539 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521097003540 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 521097003541 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 521097003542 domain interfaces; other site 521097003543 active site 521097003544 Amidinotransferase; Region: Amidinotransf; cl12043 521097003545 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 521097003546 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 521097003547 tRNA; other site 521097003548 putative tRNA binding site [nucleotide binding]; other site 521097003549 putative NADP binding site [chemical binding]; other site 521097003550 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 521097003551 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 521097003552 Family of unknown function (DUF490); Region: DUF490; pfam04357 521097003553 Predicted permeases [General function prediction only]; Region: COG0795 521097003554 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521097003555 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521097003556 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 521097003557 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 521097003558 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 521097003559 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 521097003560 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 521097003561 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 521097003562 Uncharacterized conserved protein [Function unknown]; Region: COG3743 521097003563 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 521097003564 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 521097003565 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 521097003566 putative active site [active] 521097003567 putative catalytic site [active] 521097003568 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 521097003569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097003570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097003571 dimer interface [polypeptide binding]; other site 521097003572 phosphorylation site [posttranslational modification] 521097003573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097003574 ATP binding site [chemical binding]; other site 521097003575 Mg2+ binding site [ion binding]; other site 521097003576 G-X-G motif; other site 521097003577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521097003578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097003579 active site 521097003580 phosphorylation site [posttranslational modification] 521097003581 intermolecular recognition site; other site 521097003582 dimerization interface [polypeptide binding]; other site 521097003583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097003584 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 521097003585 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097003586 SusD family; Region: SusD; pfam07980 521097003587 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097003588 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003589 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097003590 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 521097003591 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 521097003592 Transglycosylase; Region: Transgly; pfam00912 521097003593 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 521097003594 GldH lipoprotein; Region: GldH_lipo; pfam14109 521097003595 PSP1 C-terminal conserved region; Region: PSP1; cl00770 521097003596 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 521097003597 active site 521097003598 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 521097003599 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 521097003600 homodimer interface [polypeptide binding]; other site 521097003601 oligonucleotide binding site [chemical binding]; other site 521097003602 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521097003603 IHF dimer interface [polypeptide binding]; other site 521097003604 IHF - DNA interface [nucleotide binding]; other site 521097003605 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 521097003606 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 521097003607 putative active site [active] 521097003608 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 521097003609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097003610 active site 521097003611 phosphorylation site [posttranslational modification] 521097003612 intermolecular recognition site; other site 521097003613 dimerization interface [polypeptide binding]; other site 521097003614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097003615 Walker A motif; other site 521097003616 ATP binding site [chemical binding]; other site 521097003617 Walker B motif; other site 521097003618 arginine finger; other site 521097003619 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 521097003620 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 521097003621 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 521097003622 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521097003623 Beta-lactamase; Region: Beta-lactamase; cl17358 521097003624 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 521097003625 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 521097003626 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 521097003627 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 521097003628 dimer interface [polypeptide binding]; other site 521097003629 putative anticodon binding site; other site 521097003630 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 521097003631 motif 1; other site 521097003632 active site 521097003633 motif 2; other site 521097003634 motif 3; other site 521097003635 glucose/galactose transporter; Region: gluP; TIGR01272 521097003636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097003637 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003638 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097003639 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097003640 Site-specific recombinase; Region: SpecificRecomb; cl15411 521097003641 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 521097003642 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 521097003643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097003644 catalytic residue [active] 521097003645 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 521097003646 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521097003647 putative active site [active] 521097003648 substrate binding site [chemical binding]; other site 521097003649 putative cosubstrate binding site; other site 521097003650 catalytic site [active] 521097003651 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521097003652 substrate binding site [chemical binding]; other site 521097003653 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 521097003654 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 521097003655 CysD dimerization site [polypeptide binding]; other site 521097003656 G1 box; other site 521097003657 putative GEF interaction site [polypeptide binding]; other site 521097003658 GTP/Mg2+ binding site [chemical binding]; other site 521097003659 Switch I region; other site 521097003660 G2 box; other site 521097003661 G3 box; other site 521097003662 Switch II region; other site 521097003663 G4 box; other site 521097003664 G5 box; other site 521097003665 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 521097003666 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 521097003667 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 521097003668 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521097003669 inhibitor-cofactor binding pocket; inhibition site 521097003670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097003671 catalytic residue [active] 521097003672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097003673 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 521097003674 NAD(P) binding site [chemical binding]; other site 521097003675 active site 521097003676 Haemolytic domain; Region: Haemolytic; pfam01809 521097003677 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 521097003678 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 521097003679 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 521097003680 Walker A/P-loop; other site 521097003681 ATP binding site [chemical binding]; other site 521097003682 Q-loop/lid; other site 521097003683 ABC transporter signature motif; other site 521097003684 Walker B; other site 521097003685 D-loop; other site 521097003686 H-loop/switch region; other site 521097003687 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 521097003688 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 521097003689 Flavoprotein; Region: Flavoprotein; pfam02441 521097003690 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 521097003691 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 521097003692 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 521097003693 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 521097003694 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 521097003695 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 521097003696 NAD(P) binding site [chemical binding]; other site 521097003697 homotetramer interface [polypeptide binding]; other site 521097003698 homodimer interface [polypeptide binding]; other site 521097003699 active site 521097003700 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 521097003701 putative rRNA binding site [nucleotide binding]; other site 521097003702 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 521097003703 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 521097003704 Pantoate-beta-alanine ligase; Region: PanC; cd00560 521097003705 pantoate--beta-alanine ligase; Region: panC; TIGR00018 521097003706 active site 521097003707 ATP-binding site [chemical binding]; other site 521097003708 pantoate-binding site; other site 521097003709 HXXH motif; other site 521097003710 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 521097003711 active site residue [active] 521097003712 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 521097003713 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 521097003714 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 521097003715 NAD(P) binding site [chemical binding]; other site 521097003716 catalytic residues [active] 521097003717 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003718 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 521097003719 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 521097003720 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 521097003721 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 521097003722 active site 521097003723 catalytic residues [active] 521097003724 galactokinase; Provisional; Region: PRK05322 521097003725 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 521097003726 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521097003727 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 521097003728 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521097003729 Phosphotransferase enzyme family; Region: APH; pfam01636 521097003730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521097003731 active site 521097003732 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 521097003733 PAS domain; Region: PAS_9; pfam13426 521097003734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521097003735 putative active site [active] 521097003736 heme pocket [chemical binding]; other site 521097003737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521097003738 PAS domain; Region: PAS_9; pfam13426 521097003739 putative active site [active] 521097003740 heme pocket [chemical binding]; other site 521097003741 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 521097003742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521097003743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521097003744 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 521097003745 acyl-activating enzyme (AAE) consensus motif; other site 521097003746 acyl-activating enzyme (AAE) consensus motif; other site 521097003747 putative AMP binding site [chemical binding]; other site 521097003748 putative active site [active] 521097003749 putative CoA binding site [chemical binding]; other site 521097003750 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 521097003751 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097003752 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521097003753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097003754 Walker A/P-loop; other site 521097003755 ATP binding site [chemical binding]; other site 521097003756 Q-loop/lid; other site 521097003757 ABC transporter signature motif; other site 521097003758 Walker B; other site 521097003759 D-loop; other site 521097003760 H-loop/switch region; other site 521097003761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 521097003762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097003763 Coenzyme A binding pocket [chemical binding]; other site 521097003764 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521097003765 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 521097003766 ATP binding site [chemical binding]; other site 521097003767 active site 521097003768 substrate binding site [chemical binding]; other site 521097003769 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 521097003770 catalytic center binding site [active] 521097003771 ATP binding site [chemical binding]; other site 521097003772 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 521097003773 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 521097003774 Substrate-binding site [chemical binding]; other site 521097003775 Substrate specificity [chemical binding]; other site 521097003776 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 521097003777 oligomerization interface [polypeptide binding]; other site 521097003778 active site 521097003779 metal binding site [ion binding]; metal-binding site 521097003780 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 521097003781 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521097003782 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521097003783 active site 521097003784 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521097003785 Shikimate kinase; Region: SKI; pfam01202 521097003786 ADP binding site [chemical binding]; other site 521097003787 magnesium binding site [ion binding]; other site 521097003788 putative shikimate binding site; other site 521097003789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097003790 binding surface 521097003791 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521097003792 TPR motif; other site 521097003793 Bacterial SH3 domain; Region: SH3_3; pfam08239 521097003794 Oxygen tolerance; Region: BatD; pfam13584 521097003795 TPR repeat; Region: TPR_11; pfam13414 521097003796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097003797 binding surface 521097003798 TPR motif; other site 521097003799 Tetratricopeptide repeat; Region: TPR_12; pfam13424 521097003800 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 521097003801 metal ion-dependent adhesion site (MIDAS); other site 521097003802 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 521097003803 exonuclease subunit SbcC; Provisional; Region: PRK10246 521097003804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097003805 Walker A/P-loop; other site 521097003806 ATP binding site [chemical binding]; other site 521097003807 Q-loop/lid; other site 521097003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097003809 ABC transporter signature motif; other site 521097003810 Walker B; other site 521097003811 D-loop; other site 521097003812 H-loop/switch region; other site 521097003813 Protein of unknown function, DUF488; Region: DUF488; pfam04343 521097003814 Uncharacterized conserved protein [Function unknown]; Region: COG0327 521097003815 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521097003816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 521097003817 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 521097003818 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 521097003819 Putative zinc ribbon domain; Region: DUF164; pfam02591 521097003820 prolyl-tRNA synthetase; Provisional; Region: PRK08661 521097003821 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 521097003822 dimer interface [polypeptide binding]; other site 521097003823 motif 1; other site 521097003824 active site 521097003825 motif 2; other site 521097003826 motif 3; other site 521097003827 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 521097003828 anticodon binding site; other site 521097003829 zinc-binding site [ion binding]; other site 521097003830 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 521097003831 C-terminal peptidase (prc); Region: prc; TIGR00225 521097003832 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 521097003833 protein binding site [polypeptide binding]; other site 521097003834 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 521097003835 Catalytic dyad [active] 521097003836 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 521097003837 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 521097003838 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 521097003839 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 521097003840 16S rRNA methyltransferase B; Provisional; Region: PRK14902 521097003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097003842 S-adenosylmethionine binding site [chemical binding]; other site 521097003843 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 521097003844 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 521097003845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097003846 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521097003847 putative substrate translocation pore; other site 521097003848 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 521097003849 Permease; Region: Permease; pfam02405 521097003850 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 521097003851 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 521097003852 purine monophosphate binding site [chemical binding]; other site 521097003853 dimer interface [polypeptide binding]; other site 521097003854 putative catalytic residues [active] 521097003855 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 521097003856 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 521097003857 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521097003858 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521097003859 FtsX-like permease family; Region: FtsX; pfam02687 521097003860 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521097003861 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 521097003862 active site 521097003863 DNA binding site [nucleotide binding] 521097003864 Int/Topo IB signature motif; other site 521097003865 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 521097003866 30S subunit binding site; other site 521097003867 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097003868 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097003869 ligand binding site [chemical binding]; other site 521097003870 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 521097003871 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521097003872 nucleotide binding pocket [chemical binding]; other site 521097003873 K-X-D-G motif; other site 521097003874 catalytic site [active] 521097003875 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521097003876 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521097003877 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521097003878 Dimer interface [polypeptide binding]; other site 521097003879 BRCT sequence motif; other site 521097003880 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 521097003881 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 521097003882 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521097003883 Zn2+ binding site [ion binding]; other site 521097003884 Mg2+ binding site [ion binding]; other site 521097003885 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 521097003886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097003887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097003888 dimer interface [polypeptide binding]; other site 521097003889 phosphorylation site [posttranslational modification] 521097003890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097003891 ATP binding site [chemical binding]; other site 521097003892 Mg2+ binding site [ion binding]; other site 521097003893 G-X-G motif; other site 521097003894 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 521097003895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097003896 active site 521097003897 phosphorylation site [posttranslational modification] 521097003898 intermolecular recognition site; other site 521097003899 dimerization interface [polypeptide binding]; other site 521097003900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521097003901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097003902 D-lactate dehydrogenase; Provisional; Region: PRK11183 521097003903 FAD binding domain; Region: FAD_binding_4; pfam01565 521097003904 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 521097003905 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 521097003906 ParB-like nuclease domain; Region: ParB; smart00470 521097003907 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521097003908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521097003909 P-loop; other site 521097003910 Magnesium ion binding site [ion binding]; other site 521097003911 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521097003912 Magnesium ion binding site [ion binding]; other site 521097003913 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 521097003914 putative transporter; Validated; Region: PRK03818 521097003915 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 521097003916 TrkA-C domain; Region: TrkA_C; pfam02080 521097003917 TrkA-C domain; Region: TrkA_C; pfam02080 521097003918 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 521097003919 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 521097003920 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 521097003921 Glutamate binding site [chemical binding]; other site 521097003922 NAD binding site [chemical binding]; other site 521097003923 catalytic residues [active] 521097003924 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003925 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 521097003926 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097003927 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 521097003928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097003929 active site 521097003930 motif I; other site 521097003931 motif II; other site 521097003932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097003933 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 521097003934 transketolase; Reviewed; Region: PRK05899 521097003935 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521097003936 TPP-binding site [chemical binding]; other site 521097003937 dimer interface [polypeptide binding]; other site 521097003938 short chain dehydrogenase; Provisional; Region: PRK07024 521097003939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521097003940 NAD(P) binding site [chemical binding]; other site 521097003941 active site 521097003942 Patatin-like phospholipase; Region: Patatin; pfam01734 521097003943 active site 521097003944 nucleophile elbow; other site 521097003945 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 521097003946 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521097003947 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 521097003948 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 521097003949 SurA N-terminal domain; Region: SurA_N; pfam09312 521097003950 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521097003951 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 521097003952 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 521097003953 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 521097003954 dimerization interface [polypeptide binding]; other site 521097003955 ATP binding site [chemical binding]; other site 521097003956 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 521097003957 active site 521097003958 dimer interface [polypeptide binding]; other site 521097003959 metal binding site [ion binding]; metal-binding site 521097003960 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 521097003961 active site 521097003962 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 521097003963 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 521097003964 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 521097003965 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 521097003966 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097003967 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 521097003968 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 521097003969 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 521097003970 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097003971 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097003972 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097003973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521097003974 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521097003975 ligand binding site [chemical binding]; other site 521097003976 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097003977 ligand binding site [chemical binding]; other site 521097003978 OstA-like protein; Region: OstA_2; pfam13100 521097003979 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 521097003980 MraW methylase family; Region: Methyltransf_5; cl17771 521097003981 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521097003982 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521097003983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521097003984 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 521097003985 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521097003986 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 521097003987 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 521097003988 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521097003989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521097003990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521097003991 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 521097003992 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 521097003993 homodimer interface [polypeptide binding]; other site 521097003994 substrate-cofactor binding pocket; other site 521097003995 catalytic residue [active] 521097003996 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 521097003997 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 521097003998 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 521097003999 active site 521097004000 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 521097004001 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 521097004002 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 521097004003 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 521097004004 active site 521097004005 homotetramer interface [polypeptide binding]; other site 521097004006 homodimer interface [polypeptide binding]; other site 521097004007 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 521097004008 Helix-turn-helix domain; Region: HTH_18; pfam12833 521097004009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521097004010 Predicted membrane protein [Function unknown]; Region: COG3059 521097004011 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 521097004012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097004013 active site 521097004014 motif I; other site 521097004015 motif II; other site 521097004016 Rossmann-like domain; Region: Rossmann-like; pfam10727 521097004017 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 521097004018 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 521097004019 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 521097004020 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521097004021 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 521097004022 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 521097004023 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 521097004024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521097004025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097004026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521097004027 Coenzyme A binding pocket [chemical binding]; other site 521097004028 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 521097004029 ZIP Zinc transporter; Region: Zip; pfam02535 521097004030 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 521097004031 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 521097004032 dimer interface [polypeptide binding]; other site 521097004033 active site 521097004034 glycine-pyridoxal phosphate binding site [chemical binding]; other site 521097004035 folate binding site [chemical binding]; other site 521097004036 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097004037 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 521097004038 haloacid dehalogenase-like hydrolase; Provisional; Region: PLN03243 521097004039 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 521097004040 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 521097004041 Walker A/P-loop; other site 521097004042 ATP binding site [chemical binding]; other site 521097004043 Q-loop/lid; other site 521097004044 ABC transporter signature motif; other site 521097004045 Walker B; other site 521097004046 D-loop; other site 521097004047 H-loop/switch region; other site 521097004048 peptidase T; Region: peptidase-T; TIGR01882 521097004049 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 521097004050 metal binding site [ion binding]; metal-binding site 521097004051 dimer interface [polypeptide binding]; other site 521097004052 aspartate aminotransferase; Provisional; Region: PRK07568 521097004053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521097004054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097004055 homodimer interface [polypeptide binding]; other site 521097004056 catalytic residue [active] 521097004057 6-phosphofructokinase; Provisional; Region: PRK03202 521097004058 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521097004059 active site 521097004060 ADP/pyrophosphate binding site [chemical binding]; other site 521097004061 dimerization interface [polypeptide binding]; other site 521097004062 allosteric effector site; other site 521097004063 fructose-1,6-bisphosphate binding site; other site 521097004064 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 521097004065 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 521097004066 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 521097004067 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 521097004068 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 521097004069 Substrate-binding site [chemical binding]; other site 521097004070 Substrate specificity [chemical binding]; other site 521097004071 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 521097004072 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 521097004073 putative DNA binding site [nucleotide binding]; other site 521097004074 putative Zn2+ binding site [ion binding]; other site 521097004075 AsnC family; Region: AsnC_trans_reg; pfam01037 521097004076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521097004077 AMP binding site [chemical binding]; other site 521097004078 active site 521097004079 acyl-activating enzyme (AAE) consensus motif; other site 521097004080 CoA binding site [chemical binding]; other site 521097004081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521097004082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521097004083 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 521097004084 Walker A/P-loop; other site 521097004085 ATP binding site [chemical binding]; other site 521097004086 Q-loop/lid; other site 521097004087 ABC transporter signature motif; other site 521097004088 Walker B; other site 521097004089 D-loop; other site 521097004090 H-loop/switch region; other site 521097004091 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521097004092 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521097004093 active site 521097004094 HIGH motif; other site 521097004095 dimer interface [polypeptide binding]; other site 521097004096 KMSKS motif; other site 521097004097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 521097004098 Uncharacterized conserved protein [Function unknown]; Region: COG1739 521097004099 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 521097004100 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521097004101 cell surface protein SprA; Region: surface_SprA; TIGR04189 521097004102 Motility related/secretion protein; Region: SprA_N; pfam14349 521097004103 Motility related/secretion protein; Region: SprA_N; pfam14349 521097004104 Motility related/secretion protein; Region: SprA_N; pfam14349 521097004105 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521097004106 active site 521097004107 catalytic motif [active] 521097004108 Zn binding site [ion binding]; other site 521097004109 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 521097004110 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 521097004111 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521097004112 endonuclease III; Region: ENDO3c; smart00478 521097004113 minor groove reading motif; other site 521097004114 helix-hairpin-helix signature motif; other site 521097004115 substrate binding pocket [chemical binding]; other site 521097004116 active site 521097004117 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521097004118 MarR family; Region: MarR; pfam01047 521097004119 hypothetical protein; Provisional; Region: PRK02268 521097004120 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 521097004121 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521097004122 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 521097004123 putative dimer interface [polypeptide binding]; other site 521097004124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521097004125 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 521097004126 Helix-turn-helix domain; Region: HTH_18; pfam12833 521097004127 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097004128 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 521097004129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097004130 active site 521097004131 phosphorylation site [posttranslational modification] 521097004132 intermolecular recognition site; other site 521097004133 dimerization interface [polypeptide binding]; other site 521097004134 LytTr DNA-binding domain; Region: LytTR; smart00850 521097004135 Histidine kinase; Region: His_kinase; pfam06580 521097004136 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 521097004137 NADH(P)-binding; Region: NAD_binding_10; pfam13460 521097004138 NAD binding site [chemical binding]; other site 521097004139 active site 521097004140 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 521097004141 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 521097004142 active site 521097004143 Ap6A binding site [chemical binding]; other site 521097004144 nudix motif; other site 521097004145 metal binding site [ion binding]; metal-binding site 521097004146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097004147 active site 521097004148 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097004149 FtsH Extracellular; Region: FtsH_ext; pfam06480 521097004150 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521097004151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004152 Walker A motif; other site 521097004153 ATP binding site [chemical binding]; other site 521097004154 Walker B motif; other site 521097004155 arginine finger; other site 521097004156 Peptidase family M41; Region: Peptidase_M41; pfam01434 521097004157 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 521097004158 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 521097004159 nucleoside/Zn binding site; other site 521097004160 dimer interface [polypeptide binding]; other site 521097004161 catalytic motif [active] 521097004162 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 521097004163 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 521097004164 putative ligand binding site [chemical binding]; other site 521097004165 NAD binding site [chemical binding]; other site 521097004166 dimerization interface [polypeptide binding]; other site 521097004167 catalytic site [active] 521097004168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097004169 Walker A/P-loop; other site 521097004170 ATP binding site [chemical binding]; other site 521097004171 Q-loop/lid; other site 521097004172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097004173 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 521097004174 Walker A/P-loop; other site 521097004175 ATP binding site [chemical binding]; other site 521097004176 Q-loop/lid; other site 521097004177 ABC transporter signature motif; other site 521097004178 Walker B; other site 521097004179 D-loop; other site 521097004180 H-loop/switch region; other site 521097004181 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 521097004182 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 521097004183 putative active site [active] 521097004184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 521097004185 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 521097004186 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 521097004187 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 521097004188 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521097004189 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521097004190 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 521097004191 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 521097004192 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 521097004193 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 521097004194 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521097004195 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521097004196 HlyD family secretion protein; Region: HlyD_3; pfam13437 521097004197 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 521097004198 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 521097004199 chaperone protein DnaJ; Provisional; Region: PRK14299 521097004200 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521097004201 HSP70 interaction site [polypeptide binding]; other site 521097004202 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521097004203 substrate binding site [polypeptide binding]; other site 521097004204 dimer interface [polypeptide binding]; other site 521097004205 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521097004206 metal-binding site [ion binding] 521097004207 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097004208 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 521097004209 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097004210 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 521097004211 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 521097004212 metal ion-dependent adhesion site (MIDAS); other site 521097004213 Oxygen tolerance; Region: BatD; pfam13584 521097004214 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 521097004215 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521097004216 metal ion-dependent adhesion site (MIDAS); other site 521097004217 MoxR-like ATPases [General function prediction only]; Region: COG0714 521097004218 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 521097004219 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 521097004220 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521097004221 homodimer interface [polypeptide binding]; other site 521097004222 substrate-cofactor binding pocket; other site 521097004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097004224 catalytic residue [active] 521097004225 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097004226 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097004227 active site 521097004228 oxyanion hole [active] 521097004229 catalytic triad [active] 521097004230 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097004231 oxyanion hole [active] 521097004232 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 521097004233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521097004234 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521097004235 active site 521097004236 oxyanion hole [active] 521097004237 catalytic triad [active] 521097004238 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 521097004239 malate dehydrogenase; Reviewed; Region: PRK06223 521097004240 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 521097004241 dimer interface [polypeptide binding]; other site 521097004242 NAD(P) binding site [chemical binding]; other site 521097004243 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521097004244 substrate binding site [chemical binding]; other site 521097004245 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 521097004246 AAA domain; Region: AAA_26; pfam13500 521097004247 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521097004248 16S/18S rRNA binding site [nucleotide binding]; other site 521097004249 S13e-L30e interaction site [polypeptide binding]; other site 521097004250 25S rRNA binding site [nucleotide binding]; other site 521097004251 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521097004252 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521097004253 RNase E interface [polypeptide binding]; other site 521097004254 trimer interface [polypeptide binding]; other site 521097004255 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521097004256 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521097004257 RNase E interface [polypeptide binding]; other site 521097004258 trimer interface [polypeptide binding]; other site 521097004259 active site 521097004260 K homology RNA-binding domain; Region: KH; smart00322 521097004261 nucleic acid binding region [nucleotide binding]; other site 521097004262 G-X-X-G motif; other site 521097004263 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521097004264 RNA binding site [nucleotide binding]; other site 521097004265 domain interface; other site 521097004266 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 521097004267 YceG-like family; Region: YceG; pfam02618 521097004268 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 521097004269 dimerization interface [polypeptide binding]; other site 521097004270 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 521097004271 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 521097004272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097004273 binding surface 521097004274 TPR repeat; Region: TPR_11; pfam13414 521097004275 TPR motif; other site 521097004276 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521097004277 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097004278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097004279 ligand binding site [chemical binding]; other site 521097004280 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097004281 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097004282 ligand binding site [chemical binding]; other site 521097004283 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 521097004284 Predicted metalloprotease [General function prediction only]; Region: COG2321 521097004285 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 521097004286 asparagine synthetase AsnA; Provisional; Region: PRK05425 521097004287 motif 1; other site 521097004288 dimer interface [polypeptide binding]; other site 521097004289 active site 521097004290 motif 2; other site 521097004291 motif 3; other site 521097004292 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 521097004293 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097004294 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097004295 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097004296 ligand binding site [chemical binding]; other site 521097004297 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 521097004298 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521097004299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004300 Walker A motif; other site 521097004301 ATP binding site [chemical binding]; other site 521097004302 Walker B motif; other site 521097004303 arginine finger; other site 521097004304 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521097004305 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521097004306 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521097004307 RNA binding surface [nucleotide binding]; other site 521097004308 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 521097004309 active site 521097004310 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 521097004311 core domain interface [polypeptide binding]; other site 521097004312 delta subunit interface [polypeptide binding]; other site 521097004313 epsilon subunit interface [polypeptide binding]; other site 521097004314 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 521097004315 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 521097004316 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521097004317 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 521097004318 beta subunit interaction interface [polypeptide binding]; other site 521097004319 Walker A motif; other site 521097004320 ATP binding site [chemical binding]; other site 521097004321 Walker B motif; other site 521097004322 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521097004323 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 521097004324 putative active site [active] 521097004325 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 521097004326 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 521097004327 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 521097004328 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 521097004329 ATP synthase subunit C; Region: ATP-synt_C; cl00466 521097004330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521097004331 ATP synthase A chain; Region: ATP-synt_A; cl00413 521097004332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097004333 active site 521097004334 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 521097004335 Amidinotransferase; Region: Amidinotransf; pfam02274 521097004336 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 521097004337 homotrimer interaction site [polypeptide binding]; other site 521097004338 putative active site [active] 521097004339 Peptidase family M23; Region: Peptidase_M23; pfam01551 521097004340 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 521097004341 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 521097004342 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 521097004343 UGMP family protein; Validated; Region: PRK09604 521097004344 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521097004345 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521097004346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004347 S-adenosylmethionine binding site [chemical binding]; other site 521097004348 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 521097004349 active site 521097004350 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 521097004351 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 521097004352 CoA-ligase; Region: Ligase_CoA; pfam00549 521097004353 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 521097004354 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 521097004355 THF binding site; other site 521097004356 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 521097004357 substrate binding site [chemical binding]; other site 521097004358 THF binding site; other site 521097004359 zinc-binding site [ion binding]; other site 521097004360 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 521097004361 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 521097004362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004363 S-adenosylmethionine binding site [chemical binding]; other site 521097004364 putative oxidoreductase; Provisional; Region: PRK11579 521097004365 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521097004366 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 521097004367 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 521097004368 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 521097004369 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 521097004370 TPP-binding site [chemical binding]; other site 521097004371 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 521097004372 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097004373 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 521097004374 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 521097004375 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 521097004376 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 521097004377 E3 interaction surface; other site 521097004378 lipoyl attachment site [posttranslational modification]; other site 521097004379 e3 binding domain; Region: E3_binding; pfam02817 521097004380 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 521097004381 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 521097004382 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521097004383 active site 521097004384 substrate binding site [chemical binding]; other site 521097004385 metal binding site [ion binding]; metal-binding site 521097004386 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 521097004387 putative active site [active] 521097004388 putative metal binding site [ion binding]; other site 521097004389 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 521097004390 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 521097004391 putative ligand binding site [chemical binding]; other site 521097004392 putative NAD binding site [chemical binding]; other site 521097004393 catalytic site [active] 521097004394 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 521097004395 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 521097004396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004397 S-adenosylmethionine binding site [chemical binding]; other site 521097004398 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097004399 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 521097004400 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 521097004401 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521097004402 DNA polymerase III subunit beta; Validated; Region: PRK05643 521097004403 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521097004404 putative DNA binding surface [nucleotide binding]; other site 521097004405 dimer interface [polypeptide binding]; other site 521097004406 beta-clamp/clamp loader binding surface; other site 521097004407 beta-clamp/translesion DNA polymerase binding surface; other site 521097004408 Sulfatase; Region: Sulfatase; pfam00884 521097004409 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 521097004410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521097004411 Zn2+ binding site [ion binding]; other site 521097004412 Mg2+ binding site [ion binding]; other site 521097004413 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 521097004414 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 521097004415 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 521097004416 trimer interface [polypeptide binding]; other site 521097004417 active site 521097004418 UDP-GlcNAc binding site [chemical binding]; other site 521097004419 lipid binding site [chemical binding]; lipid-binding site 521097004420 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 521097004421 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 521097004422 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 521097004423 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 521097004424 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 521097004425 active site 521097004426 elongation factor P; Validated; Region: PRK00529 521097004427 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521097004428 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521097004429 RNA binding site [nucleotide binding]; other site 521097004430 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521097004431 RNA binding site [nucleotide binding]; other site 521097004432 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 521097004433 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 521097004434 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 521097004435 trimer interface [polypeptide binding]; other site 521097004436 active site 521097004437 UDP-GlcNAc binding site [chemical binding]; other site 521097004438 lipid binding site [chemical binding]; lipid-binding site 521097004439 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 521097004440 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 521097004441 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 521097004442 active site 521097004443 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 521097004444 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 521097004445 NodB motif; other site 521097004446 active site 521097004447 catalytic site [active] 521097004448 metal binding site [ion binding]; metal-binding site 521097004449 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 521097004450 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 521097004451 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 521097004452 active site 2 [active] 521097004453 dimer interface [polypeptide binding]; other site 521097004454 active site 1 [active] 521097004455 multidrug efflux protein; Reviewed; Region: PRK01766 521097004456 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 521097004457 cation binding site [ion binding]; other site 521097004458 Peptidase S46; Region: Peptidase_S46; pfam10459 521097004459 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521097004460 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 521097004461 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521097004462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097004463 FeS/SAM binding site; other site 521097004464 Predicted membrane protein [Function unknown]; Region: COG2860 521097004465 UPF0126 domain; Region: UPF0126; pfam03458 521097004466 UPF0126 domain; Region: UPF0126; pfam03458 521097004467 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521097004468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521097004469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097004470 Walker A/P-loop; other site 521097004471 ATP binding site [chemical binding]; other site 521097004472 Q-loop/lid; other site 521097004473 ABC transporter signature motif; other site 521097004474 Walker B; other site 521097004475 D-loop; other site 521097004476 H-loop/switch region; other site 521097004477 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 521097004478 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 521097004479 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 521097004480 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521097004481 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 521097004482 transcription termination factor Rho; Provisional; Region: PRK12608 521097004483 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 521097004484 RNA binding site [nucleotide binding]; other site 521097004485 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 521097004486 multimer interface [polypeptide binding]; other site 521097004487 Walker A motif; other site 521097004488 ATP binding site [chemical binding]; other site 521097004489 Walker B motif; other site 521097004490 lipoyl synthase; Provisional; Region: PRK05481 521097004491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097004492 FeS/SAM binding site; other site 521097004493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521097004494 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521097004495 FtsX-like permease family; Region: FtsX; pfam02687 521097004496 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 521097004497 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 521097004498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097004499 catalytic residue [active] 521097004500 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 521097004501 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 521097004502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521097004503 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 521097004504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004505 S-adenosylmethionine binding site [chemical binding]; other site 521097004506 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 521097004507 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 521097004508 putative active site [active] 521097004509 putative metal binding site [ion binding]; other site 521097004510 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521097004511 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521097004512 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521097004513 homodimer interface [polypeptide binding]; other site 521097004514 NADP binding site [chemical binding]; other site 521097004515 substrate binding site [chemical binding]; other site 521097004516 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 521097004517 signal recognition particle protein; Provisional; Region: PRK10867 521097004518 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 521097004519 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521097004520 P loop; other site 521097004521 GTP binding site [chemical binding]; other site 521097004522 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521097004523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 521097004524 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521097004525 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521097004526 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521097004527 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 521097004528 dihydrodipicolinate synthase; Region: dapA; TIGR00674 521097004529 dimer interface [polypeptide binding]; other site 521097004530 active site 521097004531 catalytic residue [active] 521097004532 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 521097004533 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 521097004534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521097004535 active site 521097004536 metal binding site [ion binding]; metal-binding site 521097004537 Predicted membrane protein [Function unknown]; Region: COG4485 521097004538 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 521097004539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 521097004540 N-terminal plug; other site 521097004541 ligand-binding site [chemical binding]; other site 521097004542 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 521097004543 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 521097004544 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 521097004545 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 521097004546 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 521097004547 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 521097004548 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 521097004549 active site 521097004550 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 521097004551 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 521097004552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521097004553 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 521097004554 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 521097004555 Asp-box motif; other site 521097004556 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 521097004557 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521097004558 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521097004559 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521097004560 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 521097004561 Sulfatase; Region: Sulfatase; cl17466 521097004562 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521097004563 WbqC-like protein family; Region: WbqC; pfam08889 521097004564 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 521097004565 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521097004566 Catalytic site [active] 521097004567 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521097004568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097004569 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521097004570 active site 521097004571 motif I; other site 521097004572 motif II; other site 521097004573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521097004574 dihydrodipicolinate reductase; Provisional; Region: PRK00048 521097004575 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 521097004576 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 521097004577 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 521097004578 NlpC/P60 family; Region: NLPC_P60; pfam00877 521097004579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004580 S-adenosylmethionine binding site [chemical binding]; other site 521097004581 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 521097004582 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 521097004583 5S rRNA interface [nucleotide binding]; other site 521097004584 CTC domain interface [polypeptide binding]; other site 521097004585 L16 interface [polypeptide binding]; other site 521097004586 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 521097004587 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521097004588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097004589 active site 521097004590 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097004591 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097004592 serine O-acetyltransferase; Region: cysE; TIGR01172 521097004593 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 521097004594 trimer interface [polypeptide binding]; other site 521097004595 active site 521097004596 substrate binding site [chemical binding]; other site 521097004597 CoA binding site [chemical binding]; other site 521097004598 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 521097004599 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 521097004600 dimer interface [polypeptide binding]; other site 521097004601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097004602 catalytic residue [active] 521097004603 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 521097004604 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521097004605 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 521097004606 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521097004607 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 521097004608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521097004609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521097004610 dimer interface [polypeptide binding]; other site 521097004611 phosphorylation site [posttranslational modification] 521097004612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097004613 ATP binding site [chemical binding]; other site 521097004614 Mg2+ binding site [ion binding]; other site 521097004615 G-X-G motif; other site 521097004616 Response regulator receiver domain; Region: Response_reg; pfam00072 521097004617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521097004618 active site 521097004619 phosphorylation site [posttranslational modification] 521097004620 intermolecular recognition site; other site 521097004621 dimerization interface [polypeptide binding]; other site 521097004622 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 521097004623 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 521097004624 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 521097004625 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 521097004626 dimer interface [polypeptide binding]; other site 521097004627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097004628 catalytic residue [active] 521097004629 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 521097004630 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521097004631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097004632 catalytic residue [active] 521097004633 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 521097004634 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 521097004635 Ligand binding site; other site 521097004636 Putative Catalytic site; other site 521097004637 DXD motif; other site 521097004638 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 521097004639 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521097004640 EamA-like transporter family; Region: EamA; pfam00892 521097004641 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 521097004642 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521097004643 active site 521097004644 HIGH motif; other site 521097004645 KMSKS motif; other site 521097004646 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521097004647 tRNA binding surface [nucleotide binding]; other site 521097004648 anticodon binding site; other site 521097004649 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 521097004650 dimer interface [polypeptide binding]; other site 521097004651 putative tRNA-binding site [nucleotide binding]; other site 521097004652 Predicted membrane protein [Function unknown]; Region: COG1288 521097004653 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 521097004654 Rhomboid family; Region: Rhomboid; pfam01694 521097004655 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521097004656 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521097004657 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521097004658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097004659 catalytic residue [active] 521097004660 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 521097004661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 521097004662 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 521097004663 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 521097004664 Protein export membrane protein; Region: SecD_SecF; cl14618 521097004665 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 521097004666 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521097004667 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521097004668 substrate binding pocket [chemical binding]; other site 521097004669 chain length determination region; other site 521097004670 substrate-Mg2+ binding site; other site 521097004671 catalytic residues [active] 521097004672 aspartate-rich region 1; other site 521097004673 active site lid residues [active] 521097004674 aspartate-rich region 2; other site 521097004675 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 521097004676 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 521097004677 Walker A/P-loop; other site 521097004678 ATP binding site [chemical binding]; other site 521097004679 Q-loop/lid; other site 521097004680 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 521097004681 ABC transporter signature motif; other site 521097004682 Walker B; other site 521097004683 D-loop; other site 521097004684 H-loop/switch region; other site 521097004685 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 521097004686 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 521097004687 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 521097004688 dimerization interface [polypeptide binding]; other site 521097004689 active site 521097004690 AAA-like domain; Region: AAA_10; pfam12846 521097004691 Zonular occludens toxin (Zot); Region: Zot; cl17485 521097004692 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 521097004693 FAD binding domain; Region: FAD_binding_4; pfam01565 521097004694 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521097004695 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 521097004696 active site 521097004697 catalytic residues [active] 521097004698 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 521097004699 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 521097004700 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521097004701 active site 521097004702 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521097004703 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 521097004704 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521097004705 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 521097004706 DHH family; Region: DHH; pfam01368 521097004707 DHHA1 domain; Region: DHHA1; pfam02272 521097004708 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521097004709 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 521097004710 nucleotide binding site [chemical binding]; other site 521097004711 NEF interaction site [polypeptide binding]; other site 521097004712 SBD interface [polypeptide binding]; other site 521097004713 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 521097004714 Clp amino terminal domain; Region: Clp_N; pfam02861 521097004715 Clp amino terminal domain; Region: Clp_N; pfam02861 521097004716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004717 Walker A motif; other site 521097004718 ATP binding site [chemical binding]; other site 521097004719 Walker B motif; other site 521097004720 arginine finger; other site 521097004721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004722 Walker A motif; other site 521097004723 ATP binding site [chemical binding]; other site 521097004724 Walker B motif; other site 521097004725 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521097004726 AIR carboxylase; Region: AIRC; pfam00731 521097004727 GMP synthase; Reviewed; Region: guaA; PRK00074 521097004728 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521097004729 AMP/PPi binding site [chemical binding]; other site 521097004730 candidate oxyanion hole; other site 521097004731 catalytic triad [active] 521097004732 potential glutamine specificity residues [chemical binding]; other site 521097004733 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521097004734 ATP Binding subdomain [chemical binding]; other site 521097004735 Ligand Binding sites [chemical binding]; other site 521097004736 Dimerization subdomain; other site 521097004737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 521097004738 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521097004739 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521097004740 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 521097004741 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 521097004742 ligand binding site [chemical binding]; other site 521097004743 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 521097004744 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521097004745 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 521097004746 Sel1-like repeats; Region: SEL1; smart00671 521097004747 Sel1-like repeats; Region: SEL1; smart00671 521097004748 Sel1-like repeats; Region: SEL1; smart00671 521097004749 Sel1-like repeats; Region: SEL1; smart00671 521097004750 Sel1-like repeats; Region: SEL1; smart00671 521097004751 Sel1-like repeats; Region: SEL1; smart00671 521097004752 Protein of unknown function (DUF805); Region: DUF805; pfam05656 521097004753 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 521097004754 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 521097004755 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 521097004756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 521097004757 dimer interface [polypeptide binding]; other site 521097004758 active site 521097004759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521097004760 catalytic residues [active] 521097004761 substrate binding site [chemical binding]; other site 521097004762 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 521097004763 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 521097004764 propionate/acetate kinase; Provisional; Region: PRK12379 521097004765 phosphate acetyltransferase; Reviewed; Region: PRK05632 521097004766 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521097004767 DRTGG domain; Region: DRTGG; pfam07085 521097004768 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 521097004769 Deoxyhypusine synthase; Region: DS; cl00826 521097004770 deoxyhypusine synthase; Region: dhys; TIGR00321 521097004771 SprT homologues; Region: SprT; cl01182 521097004772 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 521097004773 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 521097004774 Substrate binding site; other site 521097004775 Cupin domain; Region: Cupin_2; cl17218 521097004776 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 521097004777 catalytic motif [active] 521097004778 Catalytic residue [active] 521097004779 Pleckstrin homology-like domain; Region: PH-like; cl17171 521097004780 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 521097004781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004782 Walker A motif; other site 521097004783 ATP binding site [chemical binding]; other site 521097004784 Walker B motif; other site 521097004785 arginine finger; other site 521097004786 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521097004787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521097004788 DNA-binding site [nucleotide binding]; DNA binding site 521097004789 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521097004790 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 521097004791 ArsC family; Region: ArsC; pfam03960 521097004792 catalytic residues [active] 521097004793 SEFIR domain; Region: SEFIR; pfam08357 521097004794 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521097004795 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 521097004796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521097004797 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 521097004798 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 521097004799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521097004800 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 521097004801 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521097004802 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 521097004803 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 521097004804 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 521097004805 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 521097004806 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 521097004807 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 521097004808 ligand binding site [chemical binding]; other site 521097004809 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 521097004810 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 521097004811 active site 521097004812 Zn binding site [ion binding]; other site 521097004813 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 521097004814 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521097004815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004816 Walker A motif; other site 521097004817 ATP binding site [chemical binding]; other site 521097004818 Walker B motif; other site 521097004819 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 521097004820 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 521097004821 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 521097004822 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097004823 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097004824 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097004825 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097004826 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521097004827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521097004828 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521097004829 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521097004830 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 521097004831 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 521097004832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097004833 ATP binding site [chemical binding]; other site 521097004834 putative Mg++ binding site [ion binding]; other site 521097004835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097004836 nucleotide binding region [chemical binding]; other site 521097004837 ATP-binding site [chemical binding]; other site 521097004838 TRCF domain; Region: TRCF; pfam03461 521097004839 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521097004840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097004841 ATP binding site [chemical binding]; other site 521097004842 putative Mg++ binding site [ion binding]; other site 521097004843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097004844 nucleotide binding region [chemical binding]; other site 521097004845 ATP-binding site [chemical binding]; other site 521097004846 Endonuclease I; Region: Endonuclease_1; cl01003 521097004847 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 521097004848 putative nucleotide binding site [chemical binding]; other site 521097004849 uridine monophosphate binding site [chemical binding]; other site 521097004850 homohexameric interface [polypeptide binding]; other site 521097004851 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521097004852 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 521097004853 hinge region; other site 521097004854 peptide chain release factor 2; Validated; Region: prfB; PRK00578 521097004855 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521097004856 RF-1 domain; Region: RF-1; pfam00472 521097004857 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 521097004858 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 521097004859 active site 521097004860 catalytic site [active] 521097004861 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 521097004862 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 521097004863 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 521097004864 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 521097004865 trmE is a tRNA modification GTPase; Region: trmE; cd04164 521097004866 G1 box; other site 521097004867 GTP/Mg2+ binding site [chemical binding]; other site 521097004868 Switch I region; other site 521097004869 G2 box; other site 521097004870 Switch II region; other site 521097004871 G3 box; other site 521097004872 G4 box; other site 521097004873 G5 box; other site 521097004874 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 521097004875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521097004876 non-specific DNA binding site [nucleotide binding]; other site 521097004877 salt bridge; other site 521097004878 sequence-specific DNA binding site [nucleotide binding]; other site 521097004879 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 521097004880 putative active site [active] 521097004881 Zn binding site [ion binding]; other site 521097004882 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 521097004883 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 521097004884 putative DNA binding site [nucleotide binding]; other site 521097004885 putative Zn2+ binding site [ion binding]; other site 521097004886 AsnC family; Region: AsnC_trans_reg; pfam01037 521097004887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521097004888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 521097004889 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 521097004890 Methyltransferase domain; Region: Methyltransf_23; pfam13489 521097004891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004892 S-adenosylmethionine binding site [chemical binding]; other site 521097004893 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 521097004894 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 521097004895 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 521097004896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097004897 Walker A/P-loop; other site 521097004898 ATP binding site [chemical binding]; other site 521097004899 Q-loop/lid; other site 521097004900 ABC transporter signature motif; other site 521097004901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097004902 Walker B; other site 521097004903 D-loop; other site 521097004904 H-loop/switch region; other site 521097004905 ABC transporter; Region: ABC_tran_2; pfam12848 521097004906 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097004907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 521097004908 TPR repeat; Region: TPR_11; pfam13414 521097004909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097004910 binding surface 521097004911 TPR motif; other site 521097004912 TPR repeat; Region: TPR_11; pfam13414 521097004913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097004914 binding surface 521097004915 TPR repeat; Region: TPR_11; pfam13414 521097004916 TPR motif; other site 521097004917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521097004918 binding surface 521097004919 TPR motif; other site 521097004920 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521097004921 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521097004922 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 521097004923 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 521097004924 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 521097004925 transmembrane helices; other site 521097004926 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521097004927 classical (c) SDRs; Region: SDR_c; cd05233 521097004928 NAD(P) binding site [chemical binding]; other site 521097004929 active site 521097004930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 521097004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004932 S-adenosylmethionine binding site [chemical binding]; other site 521097004933 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 521097004934 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 521097004935 oligomer interface [polypeptide binding]; other site 521097004936 metal binding site [ion binding]; metal-binding site 521097004937 metal binding site [ion binding]; metal-binding site 521097004938 Cl binding site [ion binding]; other site 521097004939 aspartate ring; other site 521097004940 basic sphincter; other site 521097004941 putative hydrophobic gate; other site 521097004942 periplasmic entrance; other site 521097004943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097004944 S-adenosylmethionine binding site [chemical binding]; other site 521097004945 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 521097004946 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 521097004947 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 521097004948 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521097004949 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 521097004950 dimerization interface 3.5A [polypeptide binding]; other site 521097004951 active site 521097004952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 521097004953 TPR motif; other site 521097004954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097004955 binding surface 521097004956 TPR motif; other site 521097004957 TPR repeat; Region: TPR_11; pfam13414 521097004958 Peptidase family M48; Region: Peptidase_M48; pfam01435 521097004959 purine nucleoside phosphorylase; Provisional; Region: PRK08202 521097004960 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521097004961 active site 521097004962 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 521097004963 DnaA N-terminal domain; Region: DnaA_N; pfam11638 521097004964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097004965 Walker A motif; other site 521097004966 ATP binding site [chemical binding]; other site 521097004967 Walker B motif; other site 521097004968 arginine finger; other site 521097004969 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521097004970 DnaA box-binding interface [nucleotide binding]; other site 521097004971 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 521097004972 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 521097004973 hexamer interface [polypeptide binding]; other site 521097004974 ligand binding site [chemical binding]; other site 521097004975 putative active site [active] 521097004976 NAD(P) binding site [chemical binding]; other site 521097004977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 521097004978 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 521097004979 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 521097004980 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521097004981 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 521097004982 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 521097004983 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521097004984 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 521097004985 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 521097004986 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 521097004987 PLD-like domain; Region: PLDc_2; pfam13091 521097004988 putative homodimer interface [polypeptide binding]; other site 521097004989 putative active site [active] 521097004990 catalytic site [active] 521097004991 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521097004992 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097004993 ATP binding site [chemical binding]; other site 521097004994 putative Mg++ binding site [ion binding]; other site 521097004995 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 521097004996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097004997 nucleotide binding region [chemical binding]; other site 521097004998 ATP-binding site [chemical binding]; other site 521097004999 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 521097005000 multiple promoter invertase; Provisional; Region: mpi; PRK13413 521097005001 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 521097005002 catalytic residues [active] 521097005003 catalytic nucleophile [active] 521097005004 Presynaptic Site I dimer interface [polypeptide binding]; other site 521097005005 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 521097005006 Synaptic Flat tetramer interface [polypeptide binding]; other site 521097005007 Synaptic Site I dimer interface [polypeptide binding]; other site 521097005008 DNA binding site [nucleotide binding] 521097005009 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 521097005010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097005011 ATP binding site [chemical binding]; other site 521097005012 putative Mg++ binding site [ion binding]; other site 521097005013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097005014 nucleotide binding region [chemical binding]; other site 521097005015 ATP-binding site [chemical binding]; other site 521097005016 RQC domain; Region: RQC; pfam09382 521097005017 HRDC domain; Region: HRDC; pfam00570 521097005018 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 521097005019 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 521097005020 active site 521097005021 substrate-binding site [chemical binding]; other site 521097005022 metal-binding site [ion binding] 521097005023 ATP binding site [chemical binding]; other site 521097005024 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521097005025 PCRF domain; Region: PCRF; pfam03462 521097005026 RF-1 domain; Region: RF-1; pfam00472 521097005027 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 521097005028 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 521097005029 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 521097005030 active site 521097005031 RNA/DNA hybrid binding site [nucleotide binding]; other site 521097005032 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 521097005033 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 521097005034 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 521097005035 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 521097005036 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 521097005037 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 521097005038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521097005039 FeS/SAM binding site; other site 521097005040 HemN C-terminal domain; Region: HemN_C; pfam06969 521097005041 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 521097005042 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 521097005043 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 521097005044 putative ligand binding site [chemical binding]; other site 521097005045 putative NAD binding site [chemical binding]; other site 521097005046 catalytic site [active] 521097005047 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 521097005048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521097005049 catalytic residue [active] 521097005050 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 521097005051 Class I ribonucleotide reductase; Region: RNR_I; cd01679 521097005052 active site 521097005053 dimer interface [polypeptide binding]; other site 521097005054 catalytic residues [active] 521097005055 effector binding site; other site 521097005056 R2 peptide binding site; other site 521097005057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 521097005058 PAS domain; Region: PAS_9; pfam13426 521097005059 putative active site [active] 521097005060 heme pocket [chemical binding]; other site 521097005061 Preprotein translocase subunit; Region: YajC; pfam02699 521097005062 transcription antitermination factor NusB; Region: nusB; TIGR01951 521097005063 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 521097005064 IHF - DNA interface [nucleotide binding]; other site 521097005065 IHF dimer interface [polypeptide binding]; other site 521097005066 NAD-dependent deacetylase; Provisional; Region: PRK00481 521097005067 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 521097005068 NAD+ binding site [chemical binding]; other site 521097005069 substrate binding site [chemical binding]; other site 521097005070 Zn binding site [ion binding]; other site 521097005071 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 521097005072 active site 521097005073 dimer interface [polypeptide binding]; other site 521097005074 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 521097005075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521097005076 Coenzyme A binding pocket [chemical binding]; other site 521097005077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 521097005078 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 521097005079 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 521097005080 RNA binding site [nucleotide binding]; other site 521097005081 active site 521097005082 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 521097005083 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 521097005084 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 521097005085 generic binding surface II; other site 521097005086 ssDNA binding site; other site 521097005087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097005088 ATP binding site [chemical binding]; other site 521097005089 putative Mg++ binding site [ion binding]; other site 521097005090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521097005091 nucleotide binding region [chemical binding]; other site 521097005092 ATP-binding site [chemical binding]; other site 521097005093 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 521097005094 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 521097005095 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 521097005096 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 521097005097 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521097005098 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 521097005099 MgtE intracellular N domain; Region: MgtE_N; smart00924 521097005100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 521097005101 Divalent cation transporter; Region: MgtE; pfam01769 521097005102 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 521097005103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097005104 S-adenosylmethionine binding site [chemical binding]; other site 521097005105 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 521097005106 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 521097005107 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 521097005108 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 521097005109 Protein of unknown function (DUF445); Region: DUF445; pfam04286 521097005110 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 521097005111 A new structural DNA glycosylase; Region: AlkD_like; cd06561 521097005112 active site 521097005113 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 521097005114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097005115 S-adenosylmethionine binding site [chemical binding]; other site 521097005116 hypothetical protein; Provisional; Region: PRK12378 521097005117 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 521097005118 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 521097005119 putative active site [active] 521097005120 putative metal binding site [ion binding]; other site 521097005121 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 521097005122 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 521097005123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097005124 S-adenosylmethionine binding site [chemical binding]; other site 521097005125 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 521097005126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521097005127 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 521097005128 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 521097005129 active site 521097005130 Zn binding site [ion binding]; other site 521097005131 Flavin Reductases; Region: FlaRed; cl00801 521097005132 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 521097005133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097005134 Walker A/P-loop; other site 521097005135 ATP binding site [chemical binding]; other site 521097005136 Q-loop/lid; other site 521097005137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097005138 ABC transporter; Region: ABC_tran_2; pfam12848 521097005139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097005140 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 521097005141 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 521097005142 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 521097005143 CoenzymeA binding site [chemical binding]; other site 521097005144 subunit interaction site [polypeptide binding]; other site 521097005145 PHB binding site; other site 521097005146 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 521097005147 Septum formation initiator; Region: DivIC; cl17659 521097005148 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 521097005149 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 521097005150 Sugar specificity; other site 521097005151 Pyrimidine base specificity; other site 521097005152 ATP-binding site [chemical binding]; other site 521097005153 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 521097005154 trigger factor; Region: tig; TIGR00115 521097005155 Clp protease; Region: CLP_protease; pfam00574 521097005156 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521097005157 oligomer interface [polypeptide binding]; other site 521097005158 active site residues [active] 521097005159 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521097005160 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 521097005161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097005162 Walker A motif; other site 521097005163 ATP binding site [chemical binding]; other site 521097005164 Walker B motif; other site 521097005165 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521097005166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521097005167 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 521097005168 AMP-binding domain protein; Validated; Region: PRK08315 521097005169 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 521097005170 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 521097005171 acyl-activating enzyme (AAE) consensus motif; other site 521097005172 acyl-activating enzyme (AAE) consensus motif; other site 521097005173 putative AMP binding site [chemical binding]; other site 521097005174 putative active site [active] 521097005175 putative CoA binding site [chemical binding]; other site 521097005176 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 521097005177 Sulfatase; Region: Sulfatase; pfam00884 521097005178 HEAT repeats; Region: HEAT_2; pfam13646 521097005179 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521097005180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521097005181 PYR/PP interface [polypeptide binding]; other site 521097005182 dimer interface [polypeptide binding]; other site 521097005183 TPP binding site [chemical binding]; other site 521097005184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521097005185 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 521097005186 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 521097005187 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 521097005188 active site 521097005189 trimer interface [polypeptide binding]; other site 521097005190 allosteric site; other site 521097005191 active site lid [active] 521097005192 hexamer (dimer of trimers) interface [polypeptide binding]; other site 521097005193 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 521097005194 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 521097005195 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521097005196 active site 521097005197 HIGH motif; other site 521097005198 nucleotide binding site [chemical binding]; other site 521097005199 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521097005200 KMSKS motif; other site 521097005201 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521097005202 tRNA binding surface [nucleotide binding]; other site 521097005203 anticodon binding site; other site 521097005204 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521097005205 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 521097005206 Ligand binding site; other site 521097005207 Putative Catalytic site; other site 521097005208 DXD motif; other site 521097005209 DNA gyrase subunit A; Validated; Region: PRK05560 521097005210 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 521097005211 CAP-like domain; other site 521097005212 active site 521097005213 primary dimer interface [polypeptide binding]; other site 521097005214 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521097005215 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521097005216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521097005217 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521097005218 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521097005219 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521097005220 hypothetical protein; Provisional; Region: PRK14686 521097005221 Family description; Region: ACT_7; pfam13840 521097005222 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 521097005223 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521097005224 HIGH motif; other site 521097005225 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521097005226 active site 521097005227 KMSKS motif; other site 521097005228 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 521097005229 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 521097005230 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 521097005231 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 521097005232 RNA binding site [nucleotide binding]; other site 521097005233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521097005234 TPR motif; other site 521097005235 binding surface 521097005236 lipoprotein signal peptidase; Provisional; Region: PRK14788 521097005237 lipoprotein signal peptidase; Provisional; Region: PRK14787 521097005238 MutS domain III; Region: MutS_III; pfam05192 521097005239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521097005240 Walker A/P-loop; other site 521097005241 ATP binding site [chemical binding]; other site 521097005242 Q-loop/lid; other site 521097005243 ABC transporter signature motif; other site 521097005244 Walker B; other site 521097005245 D-loop; other site 521097005246 H-loop/switch region; other site 521097005247 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 521097005248 ligand binding site [chemical binding]; other site 521097005249 active site 521097005250 UGI interface [polypeptide binding]; other site 521097005251 catalytic site [active] 521097005252 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 521097005253 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 521097005254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521097005255 primosomal protein N' Region: priA; TIGR00595 521097005256 ATP binding site [chemical binding]; other site 521097005257 putative Mg++ binding site [ion binding]; other site 521097005258 helicase superfamily c-terminal domain; Region: HELICc; smart00490 521097005259 ATP-binding site [chemical binding]; other site 521097005260 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 521097005261 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 521097005262 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 521097005263 dimer interface [polypeptide binding]; other site 521097005264 tetramer interface [polypeptide binding]; other site 521097005265 PYR/PP interface [polypeptide binding]; other site 521097005266 TPP binding site [chemical binding]; other site 521097005267 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 521097005268 TPP-binding site; other site 521097005269 polyphosphate kinase; Provisional; Region: PRK05443 521097005270 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 521097005271 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 521097005272 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 521097005273 domain interface [polypeptide binding]; other site 521097005274 active site 521097005275 catalytic site [active] 521097005276 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 521097005277 domain interface [polypeptide binding]; other site 521097005278 active site 521097005279 catalytic site [active] 521097005280 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 521097005281 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 521097005282 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 521097005283 Walker A/P-loop; other site 521097005284 ATP binding site [chemical binding]; other site 521097005285 Q-loop/lid; other site 521097005286 ABC transporter signature motif; other site 521097005287 Walker B; other site 521097005288 D-loop; other site 521097005289 H-loop/switch region; other site 521097005290 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 521097005291 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 521097005292 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 521097005293 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 521097005294 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 521097005295 active site 521097005296 metal binding site [ion binding]; metal-binding site 521097005297 nudix motif; other site 521097005298 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 521097005299 putative active site [active] 521097005300 Mn binding site [ion binding]; other site 521097005301 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 521097005302 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521097005303 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521097005304 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521097005305 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 521097005306 aspartate aminotransferase; Provisional; Region: PRK05764 521097005307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521097005308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097005309 homodimer interface [polypeptide binding]; other site 521097005310 catalytic residue [active] 521097005311 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 521097005312 putative catalytic site [active] 521097005313 putative metal binding site [ion binding]; other site 521097005314 putative phosphate binding site [ion binding]; other site 521097005315 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 521097005316 active site 521097005317 Zn binding site [ion binding]; other site 521097005318 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 521097005319 Isochorismatase family; Region: Isochorismatase; pfam00857 521097005320 catalytic triad [active] 521097005321 metal binding site [ion binding]; metal-binding site 521097005322 conserved cis-peptide bond; other site 521097005323 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 521097005324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521097005325 S-adenosylmethionine binding site [chemical binding]; other site 521097005326 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 521097005327 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 521097005328 active site 521097005329 nucleophile elbow; other site 521097005330 Surface antigen; Region: Bac_surface_Ag; pfam01103 521097005331 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 521097005332 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 521097005333 metal binding site [ion binding]; metal-binding site 521097005334 dimer interface [polypeptide binding]; other site 521097005335 fumarate hydratase; Reviewed; Region: fumC; PRK00485 521097005336 Class II fumarases; Region: Fumarase_classII; cd01362 521097005337 active site 521097005338 tetramer interface [polypeptide binding]; other site 521097005339 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 521097005340 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 521097005341 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 521097005342 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521097005343 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 521097005344 active site 521097005345 NTP binding site [chemical binding]; other site 521097005346 metal binding triad [ion binding]; metal-binding site 521097005347 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 521097005348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521097005349 Zn2+ binding site [ion binding]; other site 521097005350 Mg2+ binding site [ion binding]; other site 521097005351 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 521097005352 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097005353 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 521097005354 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521097005355 active site 521097005356 substrate binding site [chemical binding]; other site 521097005357 metal binding site [ion binding]; metal-binding site 521097005358 starch binding outer membrane protein SusD; Region: SusD; cd08977 521097005359 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 521097005360 Cna protein B-type domain; Region: Cna_B_2; pfam13715 521097005361 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 521097005362 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097005363 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521097005364 Class I aldolases; Region: Aldolase_Class_I; cl17187 521097005365 catalytic residue [active] 521097005366 D-galactonate transporter; Region: 2A0114; TIGR00893 521097005367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521097005368 putative substrate translocation pore; other site 521097005369 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 521097005370 Kelch motif; Region: Kelch_1; pfam01344 521097005371 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 521097005372 dimerization interface [polypeptide binding]; other site 521097005373 putative active cleft [active] 521097005374 ribonuclease E; Reviewed; Region: rne; PRK10811 521097005375 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 521097005376 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 521097005377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521097005378 putative active site [active] 521097005379 putative metal binding site [ion binding]; other site 521097005380 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 521097005381 Part of AAA domain; Region: AAA_19; pfam13245 521097005382 Family description; Region: UvrD_C_2; pfam13538 521097005383 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 521097005384 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 521097005385 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 521097005386 Leucine rich repeat; Region: LRR_8; pfam13855 521097005387 Leucine rich repeat; Region: LRR_8; pfam13855 521097005388 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 521097005389 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 521097005390 exopolyphosphatase; Region: exo_poly_only; TIGR03706 521097005391 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 521097005392 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 521097005393 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 521097005394 active site 521097005395 substrate binding site [chemical binding]; other site 521097005396 FMN binding site [chemical binding]; other site 521097005397 putative catalytic residues [active] 521097005398 GTP-binding protein LepA; Provisional; Region: PRK05433 521097005399 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521097005400 G1 box; other site 521097005401 putative GEF interaction site [polypeptide binding]; other site 521097005402 GTP/Mg2+ binding site [chemical binding]; other site 521097005403 Switch I region; other site 521097005404 G2 box; other site 521097005405 G3 box; other site 521097005406 Switch II region; other site 521097005407 G4 box; other site 521097005408 G5 box; other site 521097005409 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 521097005410 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521097005411 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521097005412 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 521097005413 putative active site [active] 521097005414 catalytic site [active] 521097005415 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 521097005416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097005417 ATP binding site [chemical binding]; other site 521097005418 Mg2+ binding site [ion binding]; other site 521097005419 G-X-G motif; other site 521097005420 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521097005421 anchoring element; other site 521097005422 dimer interface [polypeptide binding]; other site 521097005423 ATP binding site [chemical binding]; other site 521097005424 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 521097005425 active site 521097005426 putative metal-binding site [ion binding]; other site 521097005427 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521097005428 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521097005429 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521097005430 substrate binding pocket [chemical binding]; other site 521097005431 chain length determination region; other site 521097005432 substrate-Mg2+ binding site; other site 521097005433 catalytic residues [active] 521097005434 aspartate-rich region 1; other site 521097005435 active site lid residues [active] 521097005436 aspartate-rich region 2; other site 521097005437 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 521097005438 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 521097005439 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 521097005440 shikimate binding site; other site 521097005441 NAD(P) binding site [chemical binding]; other site 521097005442 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521097005443 Methyltransferase domain; Region: Methyltransf_18; pfam12847 521097005444 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 521097005445 Ligand binding site [chemical binding]; other site 521097005446 Electron transfer flavoprotein domain; Region: ETF; pfam01012 521097005447 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 521097005448 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 521097005449 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 521097005450 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521097005451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521097005452 putative acyl-acceptor binding pocket; other site 521097005453 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 521097005454 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 521097005455 ADP-ribose binding site [chemical binding]; other site 521097005456 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 521097005457 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521097005458 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521097005459 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 521097005460 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521097005461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521097005462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521097005463 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 521097005464 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521097005465 active site 521097005466 homodimer interface [polypeptide binding]; other site 521097005467 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 521097005468 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521097005469 Clp amino terminal domain; Region: Clp_N; pfam02861 521097005470 Clp amino terminal domain; Region: Clp_N; pfam02861 521097005471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097005472 Walker A motif; other site 521097005473 ATP binding site [chemical binding]; other site 521097005474 Walker B motif; other site 521097005475 arginine finger; other site 521097005476 UvrB/uvrC motif; Region: UVR; pfam02151 521097005477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521097005478 Walker A motif; other site 521097005479 ATP binding site [chemical binding]; other site 521097005480 Walker B motif; other site 521097005481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521097005482 NlpC/P60 family; Region: NLPC_P60; pfam00877 521097005483 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 521097005484 Competence protein; Region: Competence; pfam03772 521097005485 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 521097005486 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 521097005487 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521097005488 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521097005489 RNA binding surface [nucleotide binding]; other site 521097005490 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 521097005491 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 521097005492 tetramer interface [polypeptide binding]; other site 521097005493 TPP-binding site [chemical binding]; other site 521097005494 heterodimer interface [polypeptide binding]; other site 521097005495 phosphorylation loop region [posttranslational modification] 521097005496 Predicted kinase [General function prediction only]; Region: COG4639 521097005497 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 521097005498 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 521097005499 PYR/PP interface [polypeptide binding]; other site 521097005500 dimer interface [polypeptide binding]; other site 521097005501 TPP binding site [chemical binding]; other site 521097005502 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521097005503 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 521097005504 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 521097005505 Uncharacterized conserved protein [Function unknown]; Region: COG1624 521097005506 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521097005507 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 521097005508 dihydropteroate synthase; Region: DHPS; TIGR01496 521097005509 substrate binding pocket [chemical binding]; other site 521097005510 dimer interface [polypeptide binding]; other site 521097005511 inhibitor binding site; inhibition site 521097005512 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 521097005513 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 521097005514 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 521097005515 AsmA family; Region: AsmA; pfam05170 521097005516 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 521097005517 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521097005518 catalytic core [active] 521097005519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521097005520 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521097005521 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521097005522 active site 521097005523 metal binding site [ion binding]; metal-binding site 521097005524 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 521097005525 mce related protein; Region: MCE; pfam02470 521097005526 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521097005527 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 521097005528 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521097005529 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521097005530 Walker A/P-loop; other site 521097005531 ATP binding site [chemical binding]; other site 521097005532 Q-loop/lid; other site 521097005533 ABC transporter signature motif; other site 521097005534 Walker B; other site 521097005535 D-loop; other site 521097005536 H-loop/switch region; other site 521097005537 ABC transporter; Region: ABC_tran_2; pfam12848 521097005538 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521097005539 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 521097005540 Peptidase family U32; Region: Peptidase_U32; pfam01136 521097005541 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 521097005542 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097005543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521097005544 active site 521097005545 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 521097005546 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 521097005547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521097005548 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 521097005549 FtsX-like permease family; Region: FtsX; pfam02687 521097005550 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 521097005551 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 521097005552 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521097005553 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521097005554 DNA repair protein RadA; Provisional; Region: PRK11823 521097005555 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 521097005556 Walker A motif/ATP binding site; other site 521097005557 ATP binding site [chemical binding]; other site 521097005558 Walker B motif; other site 521097005559 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521097005560 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 521097005561 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 521097005562 substrate binding site; other site 521097005563 tetramer interface; other site 521097005564 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 521097005565 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 521097005566 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 521097005567 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521097005568 SmpB-tmRNA interface; other site 521097005569 diaminopimelate decarboxylase; Region: lysA; TIGR01048 521097005570 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 521097005571 active site 521097005572 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521097005573 substrate binding site [chemical binding]; other site 521097005574 catalytic residues [active] 521097005575 dimer interface [polypeptide binding]; other site 521097005576 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 521097005577 ribosomal protein L33; Region: rpl33; CHL00104 521097005578 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 521097005579 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 521097005580 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 521097005581 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521097005582 P loop; other site 521097005583 GTP binding site [chemical binding]; other site 521097005584 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 521097005585 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 521097005586 FAD binding pocket [chemical binding]; other site 521097005587 FAD binding motif [chemical binding]; other site 521097005588 phosphate binding motif [ion binding]; other site 521097005589 beta-alpha-beta structure motif; other site 521097005590 NAD(p) ribose binding residues [chemical binding]; other site 521097005591 NAD binding pocket [chemical binding]; other site 521097005592 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 521097005593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 521097005594 catalytic loop [active] 521097005595 iron binding site [ion binding]; other site 521097005596 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 521097005597 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 521097005598 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 521097005599 Catalytic dyad [active] 521097005600 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 521097005601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521097005602 ATP binding site [chemical binding]; other site 521097005603 Mg2+ binding site [ion binding]; other site 521097005604 G-X-G motif; other site 521097005605 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 521097005606 ATP binding site [chemical binding]; other site 521097005607 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 521097005608 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 521097005609 Family of unknown function (DUF695); Region: DUF695; pfam05117 521097005610 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 521097005611 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 521097005612 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 521097005613 Tetramer interface [polypeptide binding]; other site 521097005614 active site 521097005615 FMN-binding site [chemical binding]; other site 521097005616 DNA adenine methylase (dam); Region: dam; TIGR00571 521097005617 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 521097005618 DNA methylase; Region: N6_N4_Mtase; pfam01555 521097005619 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 521097005620 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 521097005621 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 521097005622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521097005623 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521097005624 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 521097005625 Recombination protein O N terminal; Region: RecO_N; pfam11967 521097005626 Recombination protein O C terminal; Region: RecO_C; pfam02565 521097005627 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 521097005628 TRAM domain; Region: TRAM; pfam01938 521097005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097005630 S-adenosylmethionine binding site [chemical binding]; other site 521097005631 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521097005632 endonuclease III; Region: ENDO3c; smart00478 521097005633 minor groove reading motif; other site 521097005634 helix-hairpin-helix signature motif; other site 521097005635 substrate binding pocket [chemical binding]; other site 521097005636 active site 521097005637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 521097005638 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 521097005639 inhibitor-cofactor binding pocket; inhibition site 521097005640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521097005641 catalytic residue [active] 521097005642 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 521097005643 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 521097005644 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521097005645 Fn3 associated; Region: Fn3_assoc; pfam13287 521097005646 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521097005647 sugar binding site [chemical binding]; other site 521097005648 CAAX protease self-immunity; Region: Abi; pfam02517 521097005649 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 521097005650 putative SAM binding site [chemical binding]; other site 521097005651 homodimer interface [polypeptide binding]; other site 521097005652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 521097005653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 521097005654 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 521097005655 catalytic site [active] 521097005656 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 521097005657 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 521097005658 quinone interaction residues [chemical binding]; other site 521097005659 active site 521097005660 catalytic residues [active] 521097005661 FMN binding site [chemical binding]; other site 521097005662 substrate binding site [chemical binding]; other site 521097005663 hypothetical protein; Provisional; Region: PRK11820 521097005664 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 521097005665 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 521097005666 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 521097005667 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 521097005668 catalytic site [active] 521097005669 G-X2-G-X-G-K; other site 521097005670 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 521097005671 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521097005672 active site 521097005673 (T/H)XGH motif; other site 521097005674 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521097005675 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521097005676 active site 521097005677 recombination protein RecR; Reviewed; Region: recR; PRK00076 521097005678 RecR protein; Region: RecR; pfam02132 521097005679 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 521097005680 putative active site [active] 521097005681 putative metal-binding site [ion binding]; other site 521097005682 tetramer interface [polypeptide binding]; other site 521097005683 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 521097005684 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 521097005685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521097005686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521097005687 Phospholipase A1; Region: PLA1; pfam02253 521097005688 dimerization interface [polypeptide binding]; other site 521097005689 substrate binding site [chemical binding]; other site 521097005690 active site 521097005691 calcium binding site [ion binding]; other site 521097005692 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 521097005693 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 521097005694 G1 box; other site 521097005695 putative GEF interaction site [polypeptide binding]; other site 521097005696 GTP/Mg2+ binding site [chemical binding]; other site 521097005697 Switch I region; other site 521097005698 G2 box; other site 521097005699 G3 box; other site 521097005700 Switch II region; other site 521097005701 G4 box; other site 521097005702 G5 box; other site 521097005703 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 521097005704 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 521097005705 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 521097005706 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 521097005707 Protein export membrane protein; Region: SecD_SecF; pfam02355 521097005708 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 521097005709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521097005710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521097005711 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521097005712 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 521097005713 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 521097005714 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 521097005715 proline dehydrogenase; Region: PLN02681 521097005716 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 521097005717 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 521097005718 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 521097005719 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 521097005720 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 521097005721 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521097005722 active site 521097005723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521097005724 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 521097005725 ApbE family; Region: ApbE; pfam02424 521097005726 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 521097005727 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 521097005728 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521097005729 Rhomboid family; Region: Rhomboid; cl11446 521097005730 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 521097005731 ipid-A-disaccharide synthase; Provisional; Region: PRK14089