-- dump date 20140619_025708 -- class Genbank::misc_feature -- table misc_feature_note -- id note 246194000001 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 246194000002 Ribonuclease P; Region: Ribonuclease_P; cl00457 246194000003 Haemolytic domain; Region: Haemolytic; pfam01809 246194000004 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 246194000005 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 246194000006 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 246194000007 G-X-X-G motif; other site 246194000008 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 246194000009 RxxxH motif; other site 246194000010 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 246194000011 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 246194000012 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 246194000013 GTP/Mg2+ binding site [chemical binding]; other site 246194000014 G4 box; other site 246194000015 G5 box; other site 246194000016 trmE is a tRNA modification GTPase; Region: trmE; cd04164 246194000017 G1 box; other site 246194000018 G1 box; other site 246194000019 GTP/Mg2+ binding site [chemical binding]; other site 246194000020 Switch I region; other site 246194000021 Switch I region; other site 246194000022 G2 box; other site 246194000023 G2 box; other site 246194000024 Switch II region; other site 246194000025 G3 box; other site 246194000026 G3 box; other site 246194000027 Switch II region; other site 246194000028 G4 box; other site 246194000029 G5 box; other site 246194000030 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 246194000031 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 246194000032 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 246194000033 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 246194000034 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 246194000035 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 246194000036 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246194000037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246194000038 P-loop; other site 246194000039 Magnesium ion binding site [ion binding]; other site 246194000040 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246194000041 Magnesium ion binding site [ion binding]; other site 246194000042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194000043 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 246194000044 ParB-like nuclease domain; Region: ParBc; pfam02195 246194000045 KorB domain; Region: KorB; pfam08535 246194000046 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246194000047 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 246194000048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246194000049 catalytic residue [active] 246194000050 Predicted membrane protein [Function unknown]; Region: COG2855 246194000051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246194000052 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 246194000053 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 246194000054 putative dimerization interface [polypeptide binding]; other site 246194000055 hypothetical protein; Provisional; Region: PRK04194 246194000056 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 246194000057 AIR carboxylase; Region: AIRC; smart01001 246194000058 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 246194000059 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 246194000060 Ligand Binding Site [chemical binding]; other site 246194000061 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194000062 active site 246194000063 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 246194000064 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 246194000065 Uncharacterized membrane protein [Function unknown]; Region: COG3949 246194000066 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 246194000067 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 246194000068 oligomer interface [polypeptide binding]; other site 246194000069 putative active site [active] 246194000070 metal binding site [ion binding]; metal-binding site 246194000071 Uncharacterized conserved protein [Function unknown]; Region: COG0432 246194000072 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 246194000073 nucleotide binding site [chemical binding]; other site 246194000074 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 246194000075 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 246194000076 active site 246194000077 DNA binding site [nucleotide binding] 246194000078 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 246194000079 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 246194000080 putative DNA binding site [nucleotide binding]; other site 246194000081 putative homodimer interface [polypeptide binding]; other site 246194000082 putative inner membrane protein; Provisional; Region: PRK11099 246194000083 Sulphur transport; Region: Sulf_transp; pfam04143 246194000084 hypothetical protein; Provisional; Region: PRK11018 246194000085 CPxP motif; other site 246194000086 GTP-binding protein YchF; Reviewed; Region: PRK09601 246194000087 YchF GTPase; Region: YchF; cd01900 246194000088 G1 box; other site 246194000089 GTP/Mg2+ binding site [chemical binding]; other site 246194000090 Switch I region; other site 246194000091 G2 box; other site 246194000092 Switch II region; other site 246194000093 G3 box; other site 246194000094 G4 box; other site 246194000095 G5 box; other site 246194000096 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 246194000097 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 246194000098 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246194000099 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246194000100 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 246194000101 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 246194000102 ACS interaction site; other site 246194000103 CODH interaction site; other site 246194000104 cubane metal cluster (B-cluster) [ion binding]; other site 246194000105 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 246194000106 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 246194000107 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 246194000108 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 246194000109 dimer interface [polypeptide binding]; other site 246194000110 ssDNA binding site [nucleotide binding]; other site 246194000111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246194000112 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 246194000113 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 246194000114 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 246194000115 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 246194000116 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 246194000117 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 246194000118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194000119 Walker A motif; other site 246194000120 ATP binding site [chemical binding]; other site 246194000121 Walker B motif; other site 246194000122 arginine finger; other site 246194000123 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246194000124 replicative DNA helicase; Region: DnaB; TIGR00665 246194000125 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 246194000126 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 246194000127 Walker A motif; other site 246194000128 ATP binding site [chemical binding]; other site 246194000129 Walker B motif; other site 246194000130 DNA binding loops [nucleotide binding] 246194000131 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 246194000132 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246194000133 dimer interface [polypeptide binding]; other site 246194000134 PYR/PP interface [polypeptide binding]; other site 246194000135 TPP binding site [chemical binding]; other site 246194000136 substrate binding site [chemical binding]; other site 246194000137 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 246194000138 TPP-binding site [chemical binding]; other site 246194000139 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 246194000140 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194000141 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246194000142 active site 246194000143 catalytic residues [active] 246194000144 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 246194000145 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 246194000146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246194000147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246194000148 catalytic residue [active] 246194000149 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 246194000150 thymidylate kinase; Validated; Region: tmk; PRK00698 246194000151 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 246194000152 TMP-binding site; other site 246194000153 ATP-binding site [chemical binding]; other site 246194000154 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 246194000155 DNA polymerase III subunit delta'; Validated; Region: PRK08485 246194000156 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 246194000157 Protein of unknown function (DUF972); Region: DUF972; pfam06156 246194000158 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 246194000159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194000160 S-adenosylmethionine binding site [chemical binding]; other site 246194000161 Predicted methyltransferases [General function prediction only]; Region: COG0313 246194000162 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 246194000163 putative SAM binding site [chemical binding]; other site 246194000164 putative homodimer interface [polypeptide binding]; other site 246194000165 BON domain; Region: BON; pfam04972 246194000166 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 246194000167 BON domain; Region: BON; pfam04972 246194000168 BON domain; Region: BON; pfam04972 246194000169 BON domain; Region: BON; pfam04972 246194000170 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246194000171 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246194000172 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246194000173 protein binding site [polypeptide binding]; other site 246194000174 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 246194000175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246194000176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246194000177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246194000178 dimerization interface [polypeptide binding]; other site 246194000179 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 246194000180 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 246194000181 transmembrane helices; other site 246194000182 fumarate hydratase; Provisional; Region: PRK06246 246194000183 fumarate hydratase; Provisional; Region: PRK06842 246194000184 L-aspartate oxidase; Provisional; Region: PRK06175 246194000185 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 246194000186 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246194000187 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 246194000188 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246194000189 catalytic loop [active] 246194000190 iron binding site [ion binding]; other site 246194000191 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 246194000192 Cysteine-rich domain; Region: CCG; pfam02754 246194000193 Cysteine-rich domain; Region: CCG; pfam02754 246194000194 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 246194000195 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 246194000196 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 246194000197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246194000198 catalytic residue [active] 246194000199 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 246194000200 Na2 binding site [ion binding]; other site 246194000201 putative substrate binding site 1 [chemical binding]; other site 246194000202 Na binding site 1 [ion binding]; other site 246194000203 putative substrate binding site 2 [chemical binding]; other site 246194000204 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194000205 active site 246194000206 NTP binding site [chemical binding]; other site 246194000207 metal binding triad [ion binding]; metal-binding site 246194000208 antibiotic binding site [chemical binding]; other site 246194000209 Protein of unknown function DUF86; Region: DUF86; pfam01934 246194000210 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 246194000211 Nitrogen regulatory protein P-II; Region: P-II; smart00938 246194000212 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 246194000213 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 246194000214 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 246194000215 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 246194000216 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 246194000217 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246194000218 non-specific DNA interactions [nucleotide binding]; other site 246194000219 DNA binding site [nucleotide binding] 246194000220 sequence specific DNA binding site [nucleotide binding]; other site 246194000221 putative cAMP binding site [chemical binding]; other site 246194000222 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 246194000223 substrate binding site [chemical binding]; other site 246194000224 ATP binding site [chemical binding]; other site 246194000225 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 246194000226 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 246194000227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 246194000228 active site 246194000229 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194000230 active site 246194000231 NTP binding site [chemical binding]; other site 246194000232 metal binding triad [ion binding]; metal-binding site 246194000233 antibiotic binding site [chemical binding]; other site 246194000234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246194000235 Ligand Binding Site [chemical binding]; other site 246194000236 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246194000237 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 246194000238 non-specific DNA interactions [nucleotide binding]; other site 246194000239 DNA binding site [nucleotide binding] 246194000240 sequence specific DNA binding site [nucleotide binding]; other site 246194000241 putative cAMP binding site [chemical binding]; other site 246194000242 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 246194000243 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 246194000244 ACS interaction site; other site 246194000245 CODH interaction site; other site 246194000246 cubane metal cluster (B-cluster) [ion binding]; other site 246194000247 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 246194000248 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194000249 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194000250 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 246194000251 HlyD family secretion protein; Region: HlyD_3; pfam13437 246194000252 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246194000253 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246194000254 Walker A/P-loop; other site 246194000255 ATP binding site [chemical binding]; other site 246194000256 Q-loop/lid; other site 246194000257 ABC transporter signature motif; other site 246194000258 Walker B; other site 246194000259 D-loop; other site 246194000260 H-loop/switch region; other site 246194000261 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246194000262 FtsX-like permease family; Region: FtsX; pfam02687 246194000263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246194000264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194000265 dimerization interface [polypeptide binding]; other site 246194000266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194000267 dimer interface [polypeptide binding]; other site 246194000268 phosphorylation site [posttranslational modification] 246194000269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194000270 ATP binding site [chemical binding]; other site 246194000271 Mg2+ binding site [ion binding]; other site 246194000272 G-X-G motif; other site 246194000273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246194000274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194000275 active site 246194000276 phosphorylation site [posttranslational modification] 246194000277 intermolecular recognition site; other site 246194000278 dimerization interface [polypeptide binding]; other site 246194000279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246194000280 DNA binding site [nucleotide binding] 246194000281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 246194000282 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246194000283 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 246194000284 4Fe-4S binding domain; Region: Fer4; pfam00037 246194000285 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 246194000286 4Fe-4S binding domain; Region: Fer4; pfam00037 246194000287 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246194000288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194000289 FeS/SAM binding site; other site 246194000290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194000291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194000292 putative substrate translocation pore; other site 246194000293 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 246194000294 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 246194000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246194000296 Archaeal ATPase; Region: Arch_ATPase; pfam01637 246194000297 AAA domain; Region: AAA_14; pfam13173 246194000298 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 246194000299 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 246194000300 EamA-like transporter family; Region: EamA; pfam00892 246194000301 EamA-like transporter family; Region: EamA; pfam00892 246194000302 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 246194000303 Ferritin-like domain; Region: Ferritin; pfam00210 246194000304 ferroxidase diiron center [ion binding]; other site 246194000305 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194000306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194000307 Zn2+ binding site [ion binding]; other site 246194000308 Mg2+ binding site [ion binding]; other site 246194000309 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 246194000310 active site 246194000311 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 246194000312 dimer interface [polypeptide binding]; other site 246194000313 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 246194000314 Ligand Binding Site [chemical binding]; other site 246194000315 Molecular Tunnel; other site 246194000316 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 246194000317 Peptidase family M48; Region: Peptidase_M48; cl12018 246194000318 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 246194000319 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 246194000320 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 246194000321 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 246194000322 HflX GTPase family; Region: HflX; cd01878 246194000323 G1 box; other site 246194000324 GTP/Mg2+ binding site [chemical binding]; other site 246194000325 Switch I region; other site 246194000326 G2 box; other site 246194000327 G3 box; other site 246194000328 Switch II region; other site 246194000329 G4 box; other site 246194000330 G5 box; other site 246194000331 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246194000332 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246194000333 active site 246194000334 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246194000335 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246194000336 AsnC family; Region: AsnC_trans_reg; pfam01037 246194000337 hypothetical protein; Validated; Region: PRK07682 246194000338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194000339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194000340 homodimer interface [polypeptide binding]; other site 246194000341 catalytic residue [active] 246194000342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246194000343 MarR family; Region: MarR_2; cl17246 246194000344 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246194000345 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246194000346 Walker A/P-loop; other site 246194000347 ATP binding site [chemical binding]; other site 246194000348 Q-loop/lid; other site 246194000349 ABC transporter signature motif; other site 246194000350 Walker B; other site 246194000351 D-loop; other site 246194000352 H-loop/switch region; other site 246194000353 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 246194000354 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246194000355 Na binding site [ion binding]; other site 246194000356 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 246194000357 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246194000358 acyl-activating enzyme (AAE) consensus motif; other site 246194000359 AMP binding site [chemical binding]; other site 246194000360 active site 246194000361 CoA binding site [chemical binding]; other site 246194000362 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 246194000363 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246194000364 dimer interface [polypeptide binding]; other site 246194000365 PYR/PP interface [polypeptide binding]; other site 246194000366 TPP binding site [chemical binding]; other site 246194000367 substrate binding site [chemical binding]; other site 246194000368 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 246194000369 TPP-binding site; other site 246194000370 4Fe-4S binding domain; Region: Fer4; pfam00037 246194000371 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 246194000372 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 246194000373 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 246194000374 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 246194000375 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 246194000376 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 246194000377 active site 246194000378 HIGH motif; other site 246194000379 KMSK motif region; other site 246194000380 tRNA binding surface [nucleotide binding]; other site 246194000381 DALR anticodon binding domain; Region: DALR_1; smart00836 246194000382 anticodon binding site; other site 246194000383 CTP synthetase; Validated; Region: pyrG; PRK05380 246194000384 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 246194000385 Catalytic site [active] 246194000386 active site 246194000387 UTP binding site [chemical binding]; other site 246194000388 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 246194000389 active site 246194000390 putative oxyanion hole; other site 246194000391 catalytic triad [active] 246194000392 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246194000393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194000394 active site 246194000395 phosphorylation site [posttranslational modification] 246194000396 intermolecular recognition site; other site 246194000397 dimerization interface [polypeptide binding]; other site 246194000398 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 246194000399 intersubunit interface [polypeptide binding]; other site 246194000400 active site 246194000401 zinc binding site [ion binding]; other site 246194000402 Na+ binding site [ion binding]; other site 246194000403 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 246194000404 active site 246194000405 intersubunit interactions; other site 246194000406 catalytic residue [active] 246194000407 transcription termination factor Rho; Provisional; Region: rho; PRK09376 246194000408 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 246194000409 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 246194000410 RNA binding site [nucleotide binding]; other site 246194000411 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 246194000412 multimer interface [polypeptide binding]; other site 246194000413 Walker A motif; other site 246194000414 ATP binding site [chemical binding]; other site 246194000415 Walker B motif; other site 246194000416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194000417 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246194000418 FeS/SAM binding site; other site 246194000419 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 246194000420 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 246194000421 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 246194000422 heme-binding site [chemical binding]; other site 246194000423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194000424 putative CheW interface [polypeptide binding]; other site 246194000425 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194000426 Zn2+ binding site [ion binding]; other site 246194000427 Mg2+ binding site [ion binding]; other site 246194000428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194000429 Zn2+ binding site [ion binding]; other site 246194000430 Mg2+ binding site [ion binding]; other site 246194000431 FOG: CBS domain [General function prediction only]; Region: COG0517 246194000432 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc2; cd04599 246194000433 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194000434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194000435 metal binding site [ion binding]; metal-binding site 246194000436 active site 246194000437 I-site; other site 246194000438 S-adenosylmethionine synthetase; Validated; Region: PRK05250 246194000439 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 246194000440 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 246194000441 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 246194000442 GAF domain; Region: GAF_2; pfam13185 246194000443 GAF domain; Region: GAF_3; pfam13492 246194000444 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194000445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194000446 metal binding site [ion binding]; metal-binding site 246194000447 active site 246194000448 I-site; other site 246194000449 transcriptional repressor CodY; Validated; Region: PRK04158 246194000450 CodY GAF-like domain; Region: CodY; pfam06018 246194000451 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 246194000452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246194000453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194000454 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 246194000455 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 246194000456 YvrJ protein family; Region: YvrJ; pfam12841 246194000457 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 246194000458 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246194000459 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194000460 Peptidase family U32; Region: Peptidase_U32; cl03113 246194000461 Cysteine-rich domain; Region: CCG; pfam02754 246194000462 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246194000463 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246194000464 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 246194000465 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 246194000466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194000467 active site 246194000468 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246194000469 DNA-binding site [nucleotide binding]; DNA binding site 246194000470 RNA-binding motif; other site 246194000471 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246194000472 30S subunit binding site; other site 246194000473 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246194000474 DNA-binding site [nucleotide binding]; DNA binding site 246194000475 RNA-binding motif; other site 246194000476 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194000477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194000478 Zn2+ binding site [ion binding]; other site 246194000479 Mg2+ binding site [ion binding]; other site 246194000480 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 246194000481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246194000482 ATP binding site [chemical binding]; other site 246194000483 putative Mg++ binding site [ion binding]; other site 246194000484 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 246194000485 peptide chain release factor 2; Validated; Region: prfB; PRK00578 246194000486 This domain is found in peptide chain release factors; Region: PCRF; smart00937 246194000487 RF-1 domain; Region: RF-1; pfam00472 246194000488 Uncharacterized conserved protein [Function unknown]; Region: COG1284 246194000489 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246194000490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 246194000491 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 246194000492 transketolase; Reviewed; Region: PRK05899 246194000493 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 246194000494 TPP-binding site [chemical binding]; other site 246194000495 dimer interface [polypeptide binding]; other site 246194000496 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 246194000497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246194000498 PYR/PP interface [polypeptide binding]; other site 246194000499 dimer interface [polypeptide binding]; other site 246194000500 TPP binding site [chemical binding]; other site 246194000501 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246194000502 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 246194000503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194000504 Walker A/P-loop; other site 246194000505 ATP binding site [chemical binding]; other site 246194000506 Q-loop/lid; other site 246194000507 ABC transporter signature motif; other site 246194000508 Walker B; other site 246194000509 D-loop; other site 246194000510 H-loop/switch region; other site 246194000511 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 246194000512 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 246194000513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 246194000514 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246194000515 Peptidase family M23; Region: Peptidase_M23; pfam01551 246194000516 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 246194000517 C-terminal peptidase (prc); Region: prc; TIGR00225 246194000518 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 246194000519 protein binding site [polypeptide binding]; other site 246194000520 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 246194000521 Catalytic dyad [active] 246194000522 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246194000523 protein binding site [polypeptide binding]; other site 246194000524 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246194000525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246194000526 Coenzyme A binding pocket [chemical binding]; other site 246194000527 FOG: CBS domain [General function prediction only]; Region: COG0517 246194000528 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 246194000529 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 246194000530 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 246194000531 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 246194000532 active site 246194000533 Zn binding site [ion binding]; other site 246194000534 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 246194000535 hypothetical protein; Reviewed; Region: PRK09588 246194000536 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 246194000537 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 246194000538 Fe-S cluster binding site [ion binding]; other site 246194000539 active site 246194000540 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 246194000541 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 246194000542 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 246194000543 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 246194000544 ligand binding site [chemical binding]; other site 246194000545 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 246194000546 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 246194000547 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246194000548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246194000549 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 246194000550 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 246194000551 Transcriptional regulators [Transcription]; Region: GntR; COG1802 246194000552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246194000553 DNA-binding site [nucleotide binding]; DNA binding site 246194000554 FCD domain; Region: FCD; pfam07729 246194000555 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246194000556 active site 246194000557 threonine dehydratase; Provisional; Region: PRK08198 246194000558 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246194000559 tetramer interface [polypeptide binding]; other site 246194000560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194000561 catalytic residue [active] 246194000562 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 246194000563 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 246194000564 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 246194000565 Substrate binding site; other site 246194000566 Mg++ binding site; other site 246194000567 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 246194000568 active site 246194000569 substrate binding site [chemical binding]; other site 246194000570 CoA binding site [chemical binding]; other site 246194000571 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 246194000572 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 246194000573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194000574 active site 246194000575 PRC-barrel domain; Region: PRC; pfam05239 246194000576 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 246194000577 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 246194000578 5S rRNA interface [nucleotide binding]; other site 246194000579 CTC domain interface [polypeptide binding]; other site 246194000580 L16 interface [polypeptide binding]; other site 246194000581 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 246194000582 putative active site [active] 246194000583 catalytic residue [active] 246194000584 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 246194000585 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 246194000586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246194000587 ATP binding site [chemical binding]; other site 246194000588 putative Mg++ binding site [ion binding]; other site 246194000589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246194000590 nucleotide binding region [chemical binding]; other site 246194000591 ATP-binding site [chemical binding]; other site 246194000592 TRCF domain; Region: TRCF; pfam03461 246194000593 SurA N-terminal domain; Region: SurA_N_3; cl07813 246194000594 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 246194000595 stage V sporulation protein T; Region: spore_V_T; TIGR02851 246194000596 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 246194000597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 246194000598 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 246194000599 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 246194000600 putative SAM binding site [chemical binding]; other site 246194000601 putative homodimer interface [polypeptide binding]; other site 246194000602 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 246194000603 homodimer interface [polypeptide binding]; other site 246194000604 metal binding site [ion binding]; metal-binding site 246194000605 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 246194000606 homodimer interface [polypeptide binding]; other site 246194000607 active site 246194000608 putative chemical substrate binding site [chemical binding]; other site 246194000609 metal binding site [ion binding]; metal-binding site 246194000610 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 246194000611 IHF dimer interface [polypeptide binding]; other site 246194000612 IHF - DNA interface [nucleotide binding]; other site 246194000613 Stage II sporulation protein; Region: SpoIID; pfam08486 246194000614 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 246194000615 sporulation protein YabP; Region: spore_yabP; TIGR02892 246194000616 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 246194000617 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246194000618 Septum formation initiator; Region: DivIC; pfam04977 246194000619 exopolyphosphatase; Region: exo_poly_only; TIGR03706 246194000620 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 246194000621 stage II sporulation protein E; Region: spore_II_E; TIGR02865 246194000622 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 246194000623 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 246194000624 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 246194000625 Ligand Binding Site [chemical binding]; other site 246194000626 TilS substrate binding domain; Region: TilS; pfam09179 246194000627 TilS substrate C-terminal domain; Region: TilS_C; smart00977 246194000628 FtsH Extracellular; Region: FtsH_ext; pfam06480 246194000629 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 246194000630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194000631 Walker A motif; other site 246194000632 ATP binding site [chemical binding]; other site 246194000633 Walker B motif; other site 246194000634 arginine finger; other site 246194000635 Peptidase family M41; Region: Peptidase_M41; pfam01434 246194000636 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 246194000637 active site 246194000638 multimer interface [polypeptide binding]; other site 246194000639 Eukaryotic protein of unknown function (DUF846); Region: DUF846; pfam05832 246194000640 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246194000641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194000642 dimer interface [polypeptide binding]; other site 246194000643 putative CheW interface [polypeptide binding]; other site 246194000644 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246194000645 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194000646 dimer interface [polypeptide binding]; other site 246194000647 putative CheW interface [polypeptide binding]; other site 246194000648 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 246194000649 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 246194000650 O-Antigen ligase; Region: Wzy_C; pfam04932 246194000651 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 246194000652 TPR repeat; Region: TPR_11; pfam13414 246194000653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246194000654 binding surface 246194000655 TPR motif; other site 246194000656 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246194000657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246194000658 binding surface 246194000659 TPR motif; other site 246194000660 NHL repeat; Region: NHL; pfam01436 246194000661 Uncharacterized conserved protein [Function unknown]; Region: COG3391 246194000662 NHL repeat; Region: NHL; pfam01436 246194000663 NHL repeat; Region: NHL; pfam01436 246194000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194000665 S-adenosylmethionine binding site [chemical binding]; other site 246194000666 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 246194000667 4Fe-4S binding domain; Region: Fer4_5; pfam12801 246194000668 helicase 45; Provisional; Region: PTZ00424 246194000669 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246194000670 ATP binding site [chemical binding]; other site 246194000671 Mg++ binding site [ion binding]; other site 246194000672 motif III; other site 246194000673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246194000674 nucleotide binding region [chemical binding]; other site 246194000675 ATP-binding site [chemical binding]; other site 246194000676 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 246194000677 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 246194000678 Thiamine pyrophosphokinase; Region: TPK; cd07995 246194000679 active site 246194000680 dimerization interface [polypeptide binding]; other site 246194000681 thiamine binding site [chemical binding]; other site 246194000682 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 246194000683 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 246194000684 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 246194000685 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246194000686 heme-binding residues [chemical binding]; other site 246194000687 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 246194000688 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246194000689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194000690 DNA binding residues [nucleotide binding] 246194000691 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 246194000692 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 246194000693 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 246194000694 catalytic residue [active] 246194000695 putative FPP diphosphate binding site; other site 246194000696 putative FPP binding hydrophobic cleft; other site 246194000697 dimer interface [polypeptide binding]; other site 246194000698 putative IPP diphosphate binding site; other site 246194000699 H+ Antiporter protein; Region: 2A0121; TIGR00900 246194000700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194000701 putative substrate translocation pore; other site 246194000702 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 246194000703 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 246194000704 active site 246194000705 dimer interface [polypeptide binding]; other site 246194000706 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 246194000707 dimer interface [polypeptide binding]; other site 246194000708 active site 246194000709 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 246194000710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246194000711 motif II; other site 246194000712 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 246194000713 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 246194000714 Cytochrome c552; Region: Cytochrom_C552; pfam02335 246194000715 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194000716 Ferredoxin [Energy production and conversion]; Region: COG1146 246194000717 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 246194000718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246194000719 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 246194000720 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 246194000721 catalytic triad [active] 246194000722 acetyl-CoA synthetase; Provisional; Region: PRK00174 246194000723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246194000724 acyl-activating enzyme (AAE) consensus motif; other site 246194000725 AMP binding site [chemical binding]; other site 246194000726 active site 246194000727 CoA binding site [chemical binding]; other site 246194000728 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 246194000729 homotrimer interaction site [polypeptide binding]; other site 246194000730 putative active site [active] 246194000731 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 246194000732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246194000733 Coenzyme A binding pocket [chemical binding]; other site 246194000734 NAD-dependent deacetylase; Provisional; Region: PRK00481 246194000735 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 246194000736 excinuclease ABC subunit B; Provisional; Region: PRK05298 246194000737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246194000738 ATP binding site [chemical binding]; other site 246194000739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246194000740 nucleotide binding region [chemical binding]; other site 246194000741 ATP-binding site [chemical binding]; other site 246194000742 Ultra-violet resistance protein B; Region: UvrB; pfam12344 246194000743 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 246194000744 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246194000745 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246194000746 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 246194000747 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 246194000748 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 246194000749 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 246194000750 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 246194000751 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 246194000752 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 246194000753 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 246194000754 active site 246194000755 Zn binding site [ion binding]; other site 246194000756 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 246194000757 CoA binding domain; Region: CoA_binding_2; pfam13380 246194000758 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 246194000759 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 246194000760 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 246194000761 putative addiction module antidote; Region: doc_partner; TIGR02609 246194000762 Fic/DOC family; Region: Fic; cl00960 246194000763 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 246194000764 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246194000765 GIY-YIG motif/motif A; other site 246194000766 active site 246194000767 catalytic site [active] 246194000768 putative DNA binding site [nucleotide binding]; other site 246194000769 metal binding site [ion binding]; metal-binding site 246194000770 UvrB/uvrC motif; Region: UVR; pfam02151 246194000771 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 246194000772 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 246194000773 DNA binding site [nucleotide binding] 246194000774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 246194000775 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 246194000776 active site 246194000777 motif I; other site 246194000778 motif II; other site 246194000779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246194000780 motif II; other site 246194000781 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 246194000782 active site 246194000783 substrate binding site [chemical binding]; other site 246194000784 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246194000785 FMN binding site [chemical binding]; other site 246194000786 putative catalytic residues [active] 246194000787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246194000788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246194000789 nucleotide binding site [chemical binding]; other site 246194000790 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 246194000791 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246194000792 active site 246194000793 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 246194000794 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 246194000795 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 246194000796 putative substrate binding pocket [chemical binding]; other site 246194000797 dimer interface [polypeptide binding]; other site 246194000798 phosphate binding site [ion binding]; other site 246194000799 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246194000800 putative active site [active] 246194000801 putative metal binding site [ion binding]; other site 246194000802 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 246194000803 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 246194000804 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246194000805 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 246194000806 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 246194000807 trimer interface [polypeptide binding]; other site 246194000808 active site 246194000809 substrate binding site [chemical binding]; other site 246194000810 CoA binding site [chemical binding]; other site 246194000811 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 246194000812 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 246194000813 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 246194000814 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 246194000815 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 246194000816 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 246194000817 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 246194000818 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 246194000819 Phosphoglycerate kinase; Region: PGK; pfam00162 246194000820 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 246194000821 substrate binding site [chemical binding]; other site 246194000822 hinge regions; other site 246194000823 ADP binding site [chemical binding]; other site 246194000824 catalytic site [active] 246194000825 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 246194000826 triosephosphate isomerase; Provisional; Region: PRK14565 246194000827 substrate binding site [chemical binding]; other site 246194000828 dimer interface [polypeptide binding]; other site 246194000829 catalytic triad [active] 246194000830 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 246194000831 phosphoglyceromutase; Provisional; Region: PRK05434 246194000832 enolase; Provisional; Region: eno; PRK00077 246194000833 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 246194000834 dimer interface [polypeptide binding]; other site 246194000835 metal binding site [ion binding]; metal-binding site 246194000836 substrate binding pocket [chemical binding]; other site 246194000837 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 246194000838 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 246194000839 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246194000840 CoenzymeA binding site [chemical binding]; other site 246194000841 subunit interaction site [polypeptide binding]; other site 246194000842 PHB binding site; other site 246194000843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 246194000844 Zn2+ binding site [ion binding]; other site 246194000845 Mg2+ binding site [ion binding]; other site 246194000846 ribonuclease R; Region: RNase_R; TIGR02063 246194000847 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 246194000848 RNB domain; Region: RNB; pfam00773 246194000849 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 246194000850 RNA binding site [nucleotide binding]; other site 246194000851 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 246194000852 SmpB-tmRNA interface; other site 246194000853 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 246194000854 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 246194000855 catalytic residues [active] 246194000856 catalytic nucleophile [active] 246194000857 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 246194000858 Domain of unknown function (DUF955); Region: DUF955; cl01076 246194000859 Restriction endonuclease; Region: Mrr_cat; pfam04471 246194000860 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 246194000861 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 246194000862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 246194000863 trimer interface [polypeptide binding]; other site 246194000864 active site 246194000865 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246194000866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194000867 putative active site [active] 246194000868 heme pocket [chemical binding]; other site 246194000869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 246194000870 dimer interface [polypeptide binding]; other site 246194000871 phosphorylation site [posttranslational modification] 246194000872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194000873 ATP binding site [chemical binding]; other site 246194000874 G-X-G motif; other site 246194000875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246194000876 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246194000877 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246194000878 Sporulation and spore germination; Region: Germane; pfam10646 246194000879 glutamate racemase; Provisional; Region: PRK00865 246194000880 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 246194000881 B12 binding site [chemical binding]; other site 246194000882 heterodimer interface [polypeptide binding]; other site 246194000883 cobalt ligand [ion binding]; other site 246194000884 MutL protein; Region: MutL; pfam13941 246194000885 StbA protein; Region: StbA; pfam06406 246194000886 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 246194000887 substrate binding site [chemical binding]; other site 246194000888 B12 cofactor binding site [chemical binding]; other site 246194000889 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 246194000890 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 246194000891 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 246194000892 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246194000893 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 246194000894 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246194000895 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 246194000896 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 246194000897 ribonuclease PH; Reviewed; Region: rph; PRK00173 246194000898 Ribonuclease PH; Region: RNase_PH_bact; cd11362 246194000899 hexamer interface [polypeptide binding]; other site 246194000900 active site 246194000901 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 246194000902 active site 246194000903 dimerization interface [polypeptide binding]; other site 246194000904 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 246194000905 active site 246194000906 metal binding site [ion binding]; metal-binding site 246194000907 homotetramer interface [polypeptide binding]; other site 246194000908 trigger factor; Provisional; Region: tig; PRK01490 246194000909 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246194000910 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246194000911 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 246194000912 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246194000913 oligomer interface [polypeptide binding]; other site 246194000914 active site residues [active] 246194000915 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 246194000916 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 246194000917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194000918 Walker A motif; other site 246194000919 ATP binding site [chemical binding]; other site 246194000920 Walker B motif; other site 246194000921 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246194000922 Vacuolar ATP synthase subunit S1 (ATP6S1); Region: ATP-synt_S1; pfam05827 246194000923 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 246194000924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194000925 Walker A motif; other site 246194000926 ATP binding site [chemical binding]; other site 246194000927 Walker B motif; other site 246194000928 arginine finger; other site 246194000929 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246194000930 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 246194000931 Found in ATP-dependent protease La (LON); Region: LON; smart00464 246194000932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194000933 Walker A motif; other site 246194000934 ATP binding site [chemical binding]; other site 246194000935 Walker B motif; other site 246194000936 arginine finger; other site 246194000937 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246194000938 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 246194000939 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 246194000940 HIGH motif; other site 246194000941 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246194000942 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 246194000943 active site 246194000944 KMSKS motif; other site 246194000945 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 246194000946 tRNA binding surface [nucleotide binding]; other site 246194000947 anticodon binding site; other site 246194000948 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 246194000949 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 246194000950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246194000951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246194000952 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 246194000953 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 246194000954 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 246194000955 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 246194000956 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 246194000957 CoA binding domain; Region: CoA_binding; smart00881 246194000958 Maf-like protein; Reviewed; Region: PRK00078 246194000959 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 246194000960 active site 246194000961 dimer interface [polypeptide binding]; other site 246194000962 hypothetical protein; Reviewed; Region: PRK00024 246194000963 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 246194000964 MPN+ (JAMM) motif; other site 246194000965 Zinc-binding site [ion binding]; other site 246194000966 rod shape-determining protein MreB; Provisional; Region: PRK13927 246194000967 MreB and similar proteins; Region: MreB_like; cd10225 246194000968 nucleotide binding site [chemical binding]; other site 246194000969 Mg binding site [ion binding]; other site 246194000970 putative protofilament interaction site [polypeptide binding]; other site 246194000971 RodZ interaction site [polypeptide binding]; other site 246194000972 rod shape-determining protein MreC; Provisional; Region: PRK13922 246194000973 rod shape-determining protein MreC; Region: MreC; pfam04085 246194000974 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 246194000975 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 246194000976 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 246194000977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246194000978 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246194000979 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 246194000980 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 246194000981 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 246194000982 Switch I; other site 246194000983 Switch II; other site 246194000984 Septum formation topological specificity factor MinE; Region: MinE; cl00538 246194000985 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246194000986 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 246194000987 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 246194000988 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 246194000989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194000990 Peptidase family M23; Region: Peptidase_M23; pfam01551 246194000991 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 246194000992 active site 246194000993 Peptidase family M50; Region: Peptidase_M50; pfam02163 246194000994 putative substrate binding region [chemical binding]; other site 246194000995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246194000996 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 246194000997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194000998 FeS/SAM binding site; other site 246194000999 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 246194001000 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 246194001001 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 246194001002 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 246194001003 homodimer interface [polypeptide binding]; other site 246194001004 oligonucleotide binding site [chemical binding]; other site 246194001005 Rab-GTPase-TBC domain; Region: RabGAP-TBC; cl02495 246194001006 Predicted methyltransferases [General function prediction only]; Region: COG1568 246194001007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194001008 S-adenosylmethionine binding site [chemical binding]; other site 246194001009 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 246194001010 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 246194001011 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 246194001012 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 246194001013 GTPase CgtA; Reviewed; Region: obgE; PRK12297 246194001014 GTP1/OBG; Region: GTP1_OBG; pfam01018 246194001015 Obg GTPase; Region: Obg; cd01898 246194001016 G1 box; other site 246194001017 GTP/Mg2+ binding site [chemical binding]; other site 246194001018 Switch I region; other site 246194001019 G2 box; other site 246194001020 G3 box; other site 246194001021 Switch II region; other site 246194001022 G4 box; other site 246194001023 G5 box; other site 246194001024 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 246194001025 PAS fold; Region: PAS; pfam00989 246194001026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194001027 putative active site [active] 246194001028 heme pocket [chemical binding]; other site 246194001029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194001030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194001031 putative substrate translocation pore; other site 246194001032 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 246194001033 PBP superfamily domain; Region: PBP_like_2; pfam12849 246194001034 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246194001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194001036 dimer interface [polypeptide binding]; other site 246194001037 conserved gate region; other site 246194001038 putative PBP binding loops; other site 246194001039 ABC-ATPase subunit interface; other site 246194001040 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246194001041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194001042 Walker A/P-loop; other site 246194001043 ATP binding site [chemical binding]; other site 246194001044 Q-loop/lid; other site 246194001045 ABC transporter signature motif; other site 246194001046 Walker B; other site 246194001047 D-loop; other site 246194001048 H-loop/switch region; other site 246194001049 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 246194001050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246194001051 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 246194001052 putative deacylase active site [active] 246194001053 gamma-glutamyl kinase; Provisional; Region: PRK05429 246194001054 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 246194001055 nucleotide binding site [chemical binding]; other site 246194001056 homotetrameric interface [polypeptide binding]; other site 246194001057 putative phosphate binding site [ion binding]; other site 246194001058 putative allosteric binding site; other site 246194001059 PUA domain; Region: PUA; pfam01472 246194001060 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 246194001061 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194001062 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 246194001063 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 246194001064 putative catalytic cysteine [active] 246194001065 MgtE intracellular N domain; Region: MgtE_N; pfam03448 246194001066 FOG: CBS domain [General function prediction only]; Region: COG0517 246194001067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246194001068 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 246194001069 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246194001070 Uncharacterized conserved protein [Function unknown]; Region: COG1565 246194001071 Methyltransferase domain; Region: Methyltransf_18; pfam12847 246194001072 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 246194001073 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 246194001074 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 246194001075 active site 246194001076 (T/H)XGH motif; other site 246194001077 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 246194001078 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 246194001079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194001080 Zn2+ binding site [ion binding]; other site 246194001081 Mg2+ binding site [ion binding]; other site 246194001082 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 246194001083 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 246194001084 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246194001085 HIGH motif; other site 246194001086 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246194001087 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246194001088 active site 246194001089 KMSKS motif; other site 246194001090 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 246194001091 tRNA binding surface [nucleotide binding]; other site 246194001092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246194001093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246194001094 ligand binding site [chemical binding]; other site 246194001095 flexible hinge region; other site 246194001096 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246194001097 non-specific DNA interactions [nucleotide binding]; other site 246194001098 DNA binding site [nucleotide binding] 246194001099 sequence specific DNA binding site [nucleotide binding]; other site 246194001100 putative cAMP binding site [chemical binding]; other site 246194001101 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 246194001102 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246194001103 cobalamin binding residues [chemical binding]; other site 246194001104 putative BtuC binding residues; other site 246194001105 dimer interface [polypeptide binding]; other site 246194001106 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 246194001107 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246194001108 dimer interface [polypeptide binding]; other site 246194001109 putative PBP binding regions; other site 246194001110 ABC-ATPase subunit interface; other site 246194001111 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246194001112 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246194001113 Walker A/P-loop; other site 246194001114 ATP binding site [chemical binding]; other site 246194001115 Q-loop/lid; other site 246194001116 ABC transporter signature motif; other site 246194001117 Walker B; other site 246194001118 D-loop; other site 246194001119 H-loop/switch region; other site 246194001120 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 246194001121 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 246194001122 Rrf2 family protein; Region: rrf2_super; TIGR00738 246194001123 Transcriptional regulator; Region: Rrf2; pfam02082 246194001124 SLBB domain; Region: SLBB; pfam10531 246194001125 comEA protein; Region: comE; TIGR01259 246194001126 Helix-hairpin-helix motif; Region: HHH; pfam00633 246194001127 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 246194001128 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 246194001129 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 246194001130 Competence protein; Region: Competence; pfam03772 246194001131 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 246194001132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194001133 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246194001134 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246194001135 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246194001136 catalytic residue [active] 246194001137 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 246194001138 DNA polymerase III, delta subunit; Region: holA; TIGR01128 246194001139 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 246194001140 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 246194001141 stage II sporulation protein P; Region: spore_II_P; TIGR02867 246194001142 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 246194001143 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 246194001144 GTP-binding protein LepA; Provisional; Region: PRK05433 246194001145 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 246194001146 G1 box; other site 246194001147 putative GEF interaction site [polypeptide binding]; other site 246194001148 GTP/Mg2+ binding site [chemical binding]; other site 246194001149 Switch I region; other site 246194001150 G2 box; other site 246194001151 G3 box; other site 246194001152 Switch II region; other site 246194001153 G4 box; other site 246194001154 G5 box; other site 246194001155 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 246194001156 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 246194001157 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 246194001158 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 246194001159 HemN C-terminal domain; Region: HemN_C; pfam06969 246194001160 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 246194001161 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 246194001162 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 246194001163 ring oligomerisation interface [polypeptide binding]; other site 246194001164 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 246194001165 ATP/Mg binding site [chemical binding]; other site 246194001166 hinge regions; other site 246194001167 stacking interactions; other site 246194001168 GrpE; Region: GrpE; pfam01025 246194001169 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 246194001170 dimer interface [polypeptide binding]; other site 246194001171 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 246194001172 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 246194001173 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 246194001174 nucleotide binding site [chemical binding]; other site 246194001175 NEF interaction site [polypeptide binding]; other site 246194001176 SBD interface [polypeptide binding]; other site 246194001177 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 246194001178 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246194001179 HSP70 interaction site [polypeptide binding]; other site 246194001180 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246194001181 Zn binding sites [ion binding]; other site 246194001182 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246194001183 dimer interface [polypeptide binding]; other site 246194001184 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 246194001185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194001186 S-adenosylmethionine binding site [chemical binding]; other site 246194001187 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 246194001188 RNA methyltransferase, RsmE family; Region: TIGR00046 246194001189 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 246194001190 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246194001191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194001192 FeS/SAM binding site; other site 246194001193 TRAM domain; Region: TRAM; cl01282 246194001194 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 246194001195 nucleotide binding site/active site [active] 246194001196 HIT family signature motif; other site 246194001197 catalytic residue [active] 246194001198 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 246194001199 Yqey-like protein; Region: YqeY; pfam09424 246194001200 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 246194001201 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 246194001202 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 246194001203 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 246194001204 PhoH-like protein; Region: PhoH; pfam02562 246194001205 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 246194001206 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 246194001207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194001208 Zn2+ binding site [ion binding]; other site 246194001209 Mg2+ binding site [ion binding]; other site 246194001210 metal-binding heat shock protein; Provisional; Region: PRK00016 246194001211 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 246194001212 Uncharacterized conserved protein [Function unknown]; Region: COG2928 246194001213 GTPase Era; Reviewed; Region: era; PRK00089 246194001214 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 246194001215 G1 box; other site 246194001216 GTP/Mg2+ binding site [chemical binding]; other site 246194001217 Switch I region; other site 246194001218 G2 box; other site 246194001219 Switch II region; other site 246194001220 G3 box; other site 246194001221 G4 box; other site 246194001222 G5 box; other site 246194001223 KH domain; Region: KH_2; pfam07650 246194001224 L-lactate permease; Region: Lactate_perm; cl00701 246194001225 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 246194001226 FAD binding domain; Region: FAD_binding_4; pfam01565 246194001227 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246194001228 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194001229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194001230 Cysteine-rich domain; Region: CCG; pfam02754 246194001231 Cysteine-rich domain; Region: CCG; pfam02754 246194001232 Transcriptional regulators [Transcription]; Region: FadR; COG2186 246194001233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246194001234 DNA-binding site [nucleotide binding]; DNA binding site 246194001235 FCD domain; Region: FCD; pfam07729 246194001236 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 246194001237 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 246194001238 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 246194001239 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194001240 Cysteine-rich domain; Region: CCG; pfam02754 246194001241 Cysteine-rich domain; Region: CCG; pfam02754 246194001242 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 246194001243 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 246194001244 acyl-activating enzyme (AAE) consensus motif; other site 246194001245 putative AMP binding site [chemical binding]; other site 246194001246 putative active site [active] 246194001247 putative CoA binding site [chemical binding]; other site 246194001248 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 246194001249 Recombination protein O N terminal; Region: RecO_N; pfam11967 246194001250 Recombination protein O C terminal; Region: RecO_C; pfam02565 246194001251 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 246194001252 dimer interface [polypeptide binding]; other site 246194001253 motif 1; other site 246194001254 active site 246194001255 motif 2; other site 246194001256 motif 3; other site 246194001257 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 246194001258 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246194001259 HTH domain; Region: HTH_11; pfam08279 246194001260 FOG: CBS domain [General function prediction only]; Region: COG0517 246194001261 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 246194001262 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 246194001263 pyruvate phosphate dikinase; Provisional; Region: PRK09279 246194001264 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 246194001265 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246194001266 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246194001267 Predicted transcriptional regulators [Transcription]; Region: COG1725 246194001268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246194001269 DNA-binding site [nucleotide binding]; DNA binding site 246194001270 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246194001271 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246194001272 Walker A/P-loop; other site 246194001273 ATP binding site [chemical binding]; other site 246194001274 Q-loop/lid; other site 246194001275 ABC transporter signature motif; other site 246194001276 Walker B; other site 246194001277 D-loop; other site 246194001278 H-loop/switch region; other site 246194001279 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 246194001280 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 246194001281 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 246194001282 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246194001283 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246194001284 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 246194001285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194001286 Zn2+ binding site [ion binding]; other site 246194001287 Mg2+ binding site [ion binding]; other site 246194001288 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 246194001289 DNA primase, catalytic core; Region: dnaG; TIGR01391 246194001290 CHC2 zinc finger; Region: zf-CHC2; pfam01807 246194001291 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 246194001292 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 246194001293 active site 246194001294 metal binding site [ion binding]; metal-binding site 246194001295 interdomain interaction site; other site 246194001296 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 246194001297 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 246194001298 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 246194001299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194001300 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246194001301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194001302 DNA binding residues [nucleotide binding] 246194001303 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 246194001304 Family of unknown function (DUF633); Region: DUF633; pfam04816 246194001305 Uncharacterized conserved protein [Function unknown]; Region: COG0327 246194001306 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 246194001307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 246194001308 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 246194001309 Uncharacterized conserved protein [Function unknown]; Region: COG0327 246194001310 Putative zinc ribbon domain; Region: DUF164; pfam02591 246194001311 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 246194001312 four helix bundle protein; Region: TIGR02436 246194001313 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 246194001314 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246194001315 EamA-like transporter family; Region: EamA; pfam00892 246194001316 EamA-like transporter family; Region: EamA; pfam00892 246194001317 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 246194001318 active site 246194001319 dimer interfaces [polypeptide binding]; other site 246194001320 catalytic residues [active] 246194001321 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 246194001322 active site 246194001323 metal binding site [ion binding]; metal-binding site 246194001324 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 246194001325 homotrimer interaction site [polypeptide binding]; other site 246194001326 active site 246194001327 prephenate dehydrogenase; Validated; Region: PRK06545 246194001328 prephenate dehydrogenase; Validated; Region: PRK08507 246194001329 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 246194001330 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 246194001331 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 246194001332 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246194001333 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194001334 molybdopterin cofactor binding site; other site 246194001335 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194001336 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 246194001337 putative molybdopterin cofactor binding site; other site 246194001338 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246194001339 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 246194001340 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 246194001341 putative dimer interface [polypeptide binding]; other site 246194001342 active site pocket [active] 246194001343 putative cataytic base [active] 246194001344 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 246194001345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246194001346 Ferrochelatase; Region: Ferrochelatase; pfam00762 246194001347 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 246194001348 C-terminal domain interface [polypeptide binding]; other site 246194001349 active site 246194001350 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 246194001351 active site 246194001352 N-terminal domain interface [polypeptide binding]; other site 246194001353 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 246194001354 substrate binding site [chemical binding]; other site 246194001355 active site 246194001356 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 246194001357 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 246194001358 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 246194001359 dimer interface [polypeptide binding]; other site 246194001360 active site 246194001361 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 246194001362 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 246194001363 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246194001364 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 246194001365 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 246194001366 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246194001367 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 246194001368 lipoyl attachment site [posttranslational modification]; other site 246194001369 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 246194001370 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246194001371 tetramer interface [polypeptide binding]; other site 246194001372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194001373 catalytic residue [active] 246194001374 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246194001375 tetramer interface [polypeptide binding]; other site 246194001376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194001377 catalytic residue [active] 246194001378 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 246194001379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 246194001380 FeS/SAM binding site; other site 246194001381 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 246194001382 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 246194001383 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 246194001384 Uncharacterized conserved protein [Function unknown]; Region: COG2461 246194001385 Family of unknown function (DUF438); Region: DUF438; pfam04282 246194001386 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 246194001387 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 246194001388 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 246194001389 homodimer interaction site [polypeptide binding]; other site 246194001390 cofactor binding site; other site 246194001391 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 246194001392 active site 246194001393 catalytic triad [active] 246194001394 oxyanion hole [active] 246194001395 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 246194001396 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 246194001397 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246194001398 EamA-like transporter family; Region: EamA; pfam00892 246194001399 EamA-like transporter family; Region: EamA; pfam00892 246194001400 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246194001401 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246194001402 substrate binding pocket [chemical binding]; other site 246194001403 membrane-bound complex binding site; other site 246194001404 hinge residues; other site 246194001405 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 246194001406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194001407 dimer interface [polypeptide binding]; other site 246194001408 conserved gate region; other site 246194001409 putative PBP binding loops; other site 246194001410 ABC-ATPase subunit interface; other site 246194001411 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246194001412 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 246194001413 Walker A/P-loop; other site 246194001414 ATP binding site [chemical binding]; other site 246194001415 Q-loop/lid; other site 246194001416 ABC transporter signature motif; other site 246194001417 Walker B; other site 246194001418 D-loop; other site 246194001419 H-loop/switch region; other site 246194001420 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246194001421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246194001422 Coenzyme A binding pocket [chemical binding]; other site 246194001423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246194001424 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 246194001425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194001426 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 246194001427 Walker A/P-loop; other site 246194001428 ATP binding site [chemical binding]; other site 246194001429 Q-loop/lid; other site 246194001430 ABC transporter signature motif; other site 246194001431 Walker B; other site 246194001432 D-loop; other site 246194001433 H-loop/switch region; other site 246194001434 Predicted membrane protein [Function unknown]; Region: COG1511 246194001435 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 246194001436 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 246194001437 ligand binding site [chemical binding]; other site 246194001438 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 246194001439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246194001440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246194001441 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 246194001442 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 246194001443 homodimer interface [polypeptide binding]; other site 246194001444 substrate-cofactor binding pocket; other site 246194001445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194001446 catalytic residue [active] 246194001447 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 246194001448 6-phosphogluconate dehydratase; Region: edd; TIGR01196 246194001449 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 246194001450 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246194001451 PYR/PP interface [polypeptide binding]; other site 246194001452 dimer interface [polypeptide binding]; other site 246194001453 TPP binding site [chemical binding]; other site 246194001454 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246194001455 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 246194001456 TPP-binding site [chemical binding]; other site 246194001457 dimer interface [polypeptide binding]; other site 246194001458 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 246194001459 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 246194001460 putative valine binding site [chemical binding]; other site 246194001461 dimer interface [polypeptide binding]; other site 246194001462 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 246194001463 ketol-acid reductoisomerase; Provisional; Region: PRK05479 246194001464 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 246194001465 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 246194001466 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 246194001467 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246194001468 PYR/PP interface [polypeptide binding]; other site 246194001469 dimer interface [polypeptide binding]; other site 246194001470 TPP binding site [chemical binding]; other site 246194001471 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246194001472 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 246194001473 TPP-binding site [chemical binding]; other site 246194001474 dimer interface [polypeptide binding]; other site 246194001475 2-isopropylmalate synthase; Validated; Region: PRK00915 246194001476 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 246194001477 active site 246194001478 catalytic residues [active] 246194001479 metal binding site [ion binding]; metal-binding site 246194001480 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 246194001481 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 246194001482 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 246194001483 substrate binding site [chemical binding]; other site 246194001484 ligand binding site [chemical binding]; other site 246194001485 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 246194001486 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 246194001487 substrate binding site [chemical binding]; other site 246194001488 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 246194001489 tartrate dehydrogenase; Region: TTC; TIGR02089 246194001490 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 246194001491 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 246194001492 active site 246194001493 catalytic residues [active] 246194001494 metal binding site [ion binding]; metal-binding site 246194001495 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 246194001496 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 246194001497 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 246194001498 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246194001499 active site 246194001500 metal binding site [ion binding]; metal-binding site 246194001501 homotetramer interface [polypeptide binding]; other site 246194001502 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 246194001503 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 246194001504 HIGH motif; other site 246194001505 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246194001506 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 246194001507 active site 246194001508 KMSKS motif; other site 246194001509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 246194001510 tRNA binding surface [nucleotide binding]; other site 246194001511 anticodon binding site; other site 246194001512 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246194001513 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246194001514 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246194001515 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 246194001516 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 246194001517 motif 1; other site 246194001518 active site 246194001519 motif 2; other site 246194001520 motif 3; other site 246194001521 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 246194001522 hypothetical protein; Provisional; Region: PRK05473 246194001523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246194001524 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246194001525 active site 246194001526 catalytic tetrad [active] 246194001527 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194001528 4Fe-4S binding domain; Region: Fer4; pfam00037 246194001529 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 246194001530 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 246194001531 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 246194001532 VanW like protein; Region: VanW; pfam04294 246194001533 G5 domain; Region: G5; pfam07501 246194001534 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 246194001535 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 246194001536 NAD binding site [chemical binding]; other site 246194001537 homodimer interface [polypeptide binding]; other site 246194001538 active site 246194001539 substrate binding site [chemical binding]; other site 246194001540 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 246194001541 MviN-like protein; Region: MVIN; pfam03023 246194001542 YceG-like family; Region: YceG; pfam02618 246194001543 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 246194001544 dimerization interface [polypeptide binding]; other site 246194001545 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 246194001546 Peptidase family U32; Region: Peptidase_U32; pfam01136 246194001547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194001548 non-specific DNA binding site [nucleotide binding]; other site 246194001549 salt bridge; other site 246194001550 sequence-specific DNA binding site [nucleotide binding]; other site 246194001551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194001552 non-specific DNA binding site [nucleotide binding]; other site 246194001553 salt bridge; other site 246194001554 sequence-specific DNA binding site [nucleotide binding]; other site 246194001555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246194001556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194001557 non-specific DNA binding site [nucleotide binding]; other site 246194001558 salt bridge; other site 246194001559 sequence-specific DNA binding site [nucleotide binding]; other site 246194001560 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 246194001561 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246194001562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194001563 S-adenosylmethionine binding site [chemical binding]; other site 246194001564 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246194001565 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246194001566 catalytic residues [active] 246194001567 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 246194001568 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246194001569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194001570 S-adenosylmethionine binding site [chemical binding]; other site 246194001571 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 246194001572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194001573 FeS/SAM binding site; other site 246194001574 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246194001575 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246194001576 catalytic residues [active] 246194001577 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246194001578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246194001579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194001580 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 246194001581 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 246194001582 MerT mercuric transport protein; Region: MerT; cl03578 246194001583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246194001584 active site residue [active] 246194001585 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 246194001586 catalytic residues [active] 246194001587 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 246194001588 Rubrerythrin [Energy production and conversion]; Region: COG1592 246194001589 diiron binding motif [ion binding]; other site 246194001590 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 246194001591 active site 246194001592 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 246194001593 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 246194001594 Walker A; other site 246194001595 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 246194001596 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246194001597 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 246194001598 active site 246194001599 acyl-activating enzyme (AAE) consensus motif; other site 246194001600 putative CoA binding site [chemical binding]; other site 246194001601 AMP binding site [chemical binding]; other site 246194001602 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 246194001603 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 246194001604 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 246194001605 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 246194001606 TPP-binding site [chemical binding]; other site 246194001607 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 246194001608 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246194001609 dimer interface [polypeptide binding]; other site 246194001610 PYR/PP interface [polypeptide binding]; other site 246194001611 TPP binding site [chemical binding]; other site 246194001612 substrate binding site [chemical binding]; other site 246194001613 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246194001614 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194001615 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194001616 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 246194001617 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 246194001618 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 246194001619 NAD binding site [chemical binding]; other site 246194001620 Phe binding site; other site 246194001621 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 246194001622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194001623 putative active site [active] 246194001624 heme pocket [chemical binding]; other site 246194001625 PAS domain; Region: PAS; smart00091 246194001626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194001627 Walker A motif; other site 246194001628 ATP binding site [chemical binding]; other site 246194001629 Walker B motif; other site 246194001630 arginine finger; other site 246194001631 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194001632 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 246194001633 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 246194001634 dimer interface [polypeptide binding]; other site 246194001635 active site 246194001636 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 246194001637 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 246194001638 thymidine kinase; Provisional; Region: PRK04296 246194001639 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 246194001640 Hemerythrin-like domain; Region: Hr-like; cd12108 246194001641 Fe binding site [ion binding]; other site 246194001642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194001643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194001644 putative substrate translocation pore; other site 246194001645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194001646 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 246194001647 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246194001648 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246194001649 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246194001650 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 246194001651 dimer interface [polypeptide binding]; other site 246194001652 acyl-activating enzyme (AAE) consensus motif; other site 246194001653 putative active site [active] 246194001654 AMP binding site [chemical binding]; other site 246194001655 putative CoA binding site [chemical binding]; other site 246194001656 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 246194001657 putative ADP-ribose binding site [chemical binding]; other site 246194001658 putative active site [active] 246194001659 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246194001660 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246194001661 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 246194001662 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 246194001663 Transposase IS200 like; Region: Y1_Tnp; pfam01797 246194001664 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 246194001665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194001666 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246194001667 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 246194001668 [4Fe-4S] binding site [ion binding]; other site 246194001669 molybdopterin cofactor binding site; other site 246194001670 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 246194001671 molybdopterin cofactor binding site; other site 246194001672 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246194001673 4Fe-4S binding domain; Region: Fer4; cl02805 246194001674 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 246194001675 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246194001676 heme-binding residues [chemical binding]; other site 246194001677 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 246194001678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246194001679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194001680 dimerization interface [polypeptide binding]; other site 246194001681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194001682 dimer interface [polypeptide binding]; other site 246194001683 phosphorylation site [posttranslational modification] 246194001684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194001685 ATP binding site [chemical binding]; other site 246194001686 Mg2+ binding site [ion binding]; other site 246194001687 G-X-G motif; other site 246194001688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246194001689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194001690 active site 246194001691 phosphorylation site [posttranslational modification] 246194001692 intermolecular recognition site; other site 246194001693 dimerization interface [polypeptide binding]; other site 246194001694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246194001695 DNA binding site [nucleotide binding] 246194001696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246194001697 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 246194001698 Cytochrome c552; Region: Cytochrom_C552; pfam02335 246194001699 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 246194001700 SurA N-terminal domain; Region: SurA_N_3; cl07813 246194001701 sporulation sigma factor SigK; Reviewed; Region: PRK05803 246194001702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194001703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194001704 DNA binding residues [nucleotide binding] 246194001705 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246194001706 K+ potassium transporter; Region: K_trans; cl15781 246194001707 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 246194001708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246194001709 Chromate transporter; Region: Chromate_transp; pfam02417 246194001710 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 246194001711 putative MPT binding site; other site 246194001712 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 246194001713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246194001714 active site 246194001715 motif I; other site 246194001716 motif II; other site 246194001717 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 246194001718 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246194001719 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 246194001720 shikimate binding site; other site 246194001721 NAD(P) binding site [chemical binding]; other site 246194001722 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 246194001723 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 246194001724 Tetramer interface [polypeptide binding]; other site 246194001725 active site 246194001726 FMN-binding site [chemical binding]; other site 246194001727 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 246194001728 CPxP motif; other site 246194001729 Sulphur transport; Region: Sulf_transp; pfam04143 246194001730 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 246194001731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246194001732 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 246194001733 putative dimerization interface [polypeptide binding]; other site 246194001734 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 246194001735 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 246194001736 ADP binding site [chemical binding]; other site 246194001737 magnesium binding site [ion binding]; other site 246194001738 putative shikimate binding site; other site 246194001739 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 246194001740 active site 246194001741 dimer interface [polypeptide binding]; other site 246194001742 metal binding site [ion binding]; metal-binding site 246194001743 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 246194001744 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246194001745 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 246194001746 Walker A motif; other site 246194001747 ATP binding site [chemical binding]; other site 246194001748 Walker B motif; other site 246194001749 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 246194001750 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 246194001751 Walker A motif; other site 246194001752 ATP binding site [chemical binding]; other site 246194001753 Walker B motif; other site 246194001754 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 246194001755 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246194001756 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246194001757 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 246194001758 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 246194001759 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 246194001760 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 246194001761 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 246194001762 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246194001763 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246194001764 Competence protein A; Region: Competence_A; pfam11104 246194001765 Cell division protein FtsA; Region: FtsA; pfam14450 246194001766 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 246194001767 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 246194001768 Pilus assembly protein, PilO; Region: PilO; cl01234 246194001769 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246194001770 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246194001771 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 246194001772 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246194001773 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 246194001774 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 246194001775 ferric uptake regulator; Provisional; Region: fur; PRK09462 246194001776 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246194001777 metal binding site 2 [ion binding]; metal-binding site 246194001778 putative DNA binding helix; other site 246194001779 metal binding site 1 [ion binding]; metal-binding site 246194001780 dimer interface [polypeptide binding]; other site 246194001781 structural Zn2+ binding site [ion binding]; other site 246194001782 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246194001783 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 246194001784 intersubunit interface [polypeptide binding]; other site 246194001785 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 246194001786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246194001787 ABC-ATPase subunit interface; other site 246194001788 dimer interface [polypeptide binding]; other site 246194001789 putative PBP binding regions; other site 246194001790 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246194001791 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246194001792 protein binding site [polypeptide binding]; other site 246194001793 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246194001794 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246194001795 Histidine kinase; Region: His_kinase; pfam06580 246194001796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194001797 ATP binding site [chemical binding]; other site 246194001798 Mg2+ binding site [ion binding]; other site 246194001799 G-X-G motif; other site 246194001800 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 246194001801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194001802 active site 246194001803 phosphorylation site [posttranslational modification] 246194001804 intermolecular recognition site; other site 246194001805 dimerization interface [polypeptide binding]; other site 246194001806 LytTr DNA-binding domain; Region: LytTR; smart00850 246194001807 acetyl-CoA synthetase; Provisional; Region: PRK00174 246194001808 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 246194001809 active site 246194001810 CoA binding site [chemical binding]; other site 246194001811 acyl-activating enzyme (AAE) consensus motif; other site 246194001812 AMP binding site [chemical binding]; other site 246194001813 acetate binding site [chemical binding]; other site 246194001814 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 246194001815 putative carbohydrate kinase; Provisional; Region: PRK10565 246194001816 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 246194001817 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 246194001818 putative substrate binding site [chemical binding]; other site 246194001819 putative ATP binding site [chemical binding]; other site 246194001820 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 246194001821 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 246194001822 hexamer interface [polypeptide binding]; other site 246194001823 ligand binding site [chemical binding]; other site 246194001824 putative active site [active] 246194001825 NAD(P) binding site [chemical binding]; other site 246194001826 alanine racemase; Reviewed; Region: alr; PRK00053 246194001827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 246194001828 active site 246194001829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246194001830 dimer interface [polypeptide binding]; other site 246194001831 substrate binding site [chemical binding]; other site 246194001832 catalytic residues [active] 246194001833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194001834 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246194001835 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 246194001836 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 246194001837 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 246194001838 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 246194001839 active site 246194001840 homotetramer interface [polypeptide binding]; other site 246194001841 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 246194001842 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 246194001843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194001844 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246194001845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246194001846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246194001847 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246194001848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246194001849 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 246194001850 NlpC/P60 family; Region: NLPC_P60; pfam00877 246194001851 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 246194001852 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 246194001853 active site 246194001854 dimer interface [polypeptide binding]; other site 246194001855 effector binding site; other site 246194001856 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246194001857 protein-splicing catalytic site; other site 246194001858 thioester formation/cholesterol transfer; other site 246194001859 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 246194001860 TSCPD domain; Region: TSCPD; pfam12637 246194001861 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246194001862 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246194001863 DNA binding residues [nucleotide binding] 246194001864 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 246194001865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194001866 non-specific DNA binding site [nucleotide binding]; other site 246194001867 salt bridge; other site 246194001868 sequence-specific DNA binding site [nucleotide binding]; other site 246194001869 Cupin domain; Region: Cupin_2; pfam07883 246194001870 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 246194001871 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246194001872 active site 246194001873 Isochorismatase family; Region: Isochorismatase; pfam00857 246194001874 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 246194001875 catalytic triad [active] 246194001876 conserved cis-peptide bond; other site 246194001877 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 246194001878 Flavoprotein; Region: Flavoprotein; pfam02441 246194001879 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 246194001880 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 246194001881 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 246194001882 Hexamer interface [polypeptide binding]; other site 246194001883 Hexagonal pore residue; other site 246194001884 propanediol utilization protein PduB; Provisional; Region: PRK15415 246194001885 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 246194001886 putative hexamer interface [polypeptide binding]; other site 246194001887 putative hexagonal pore; other site 246194001888 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 246194001889 putative hexamer interface [polypeptide binding]; other site 246194001890 putative hexagonal pore; other site 246194001891 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 246194001892 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 246194001893 Hexamer interface [polypeptide binding]; other site 246194001894 Hexagonal pore residue; other site 246194001895 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 246194001896 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 246194001897 Hexamer interface [polypeptide binding]; other site 246194001898 Hexagonal pore residue; other site 246194001899 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 246194001900 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246194001901 nucleotide binding site [chemical binding]; other site 246194001902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246194001903 nucleotide binding site [chemical binding]; other site 246194001904 Flavoprotein; Region: Flavoprotein; cl08021 246194001905 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 246194001906 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 246194001907 Hexamer/Pentamer interface [polypeptide binding]; other site 246194001908 central pore; other site 246194001909 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 246194001910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246194001911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246194001912 active site 246194001913 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 246194001914 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 246194001915 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 246194001916 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246194001917 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246194001918 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 246194001919 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 246194001920 Ligand binding site; other site 246194001921 metal-binding site 246194001922 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 246194001923 glutamate formiminotransferase; Region: FtcD; TIGR02024 246194001924 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 246194001925 Formiminotransferase domain; Region: FTCD; pfam02971 246194001926 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 246194001927 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 246194001928 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 246194001929 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 246194001930 active site 246194001931 putative substrate binding pocket [chemical binding]; other site 246194001932 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 246194001933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246194001934 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 246194001935 active site 246194001936 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 246194001937 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 246194001938 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 246194001939 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 246194001940 putative L-serine binding site [chemical binding]; other site 246194001941 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 246194001942 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 246194001943 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 246194001944 Response regulator receiver domain; Region: Response_reg; pfam00072 246194001945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194001946 active site 246194001947 phosphorylation site [posttranslational modification] 246194001948 intermolecular recognition site; other site 246194001949 dimerization interface [polypeptide binding]; other site 246194001950 ANTAR domain; Region: ANTAR; pfam03861 246194001951 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246194001952 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246194001953 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246194001954 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194001955 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194001956 metal binding site [ion binding]; metal-binding site 246194001957 active site 246194001958 I-site; other site 246194001959 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 246194001960 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 246194001961 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 246194001962 putative active site [active] 246194001963 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194001964 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 246194001965 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246194001966 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 246194001967 active site 246194001968 FMN binding site [chemical binding]; other site 246194001969 substrate binding site [chemical binding]; other site 246194001970 3Fe-4S cluster binding site [ion binding]; other site 246194001971 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 246194001972 putative subunit interface; other site 246194001973 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 246194001974 ANTAR domain; Region: ANTAR; pfam03861 246194001975 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246194001976 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246194001977 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246194001978 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 246194001979 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246194001980 active site 246194001981 FMN binding site [chemical binding]; other site 246194001982 substrate binding site [chemical binding]; other site 246194001983 3Fe-4S cluster binding site [ion binding]; other site 246194001984 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246194001985 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246194001986 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246194001987 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 246194001988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246194001989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194001990 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246194001991 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 246194001992 Cysteine-rich domain; Region: CCG; pfam02754 246194001993 Cysteine-rich domain; Region: CCG; pfam02754 246194001994 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194001995 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 246194001996 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 246194001997 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 246194001998 PemK-like protein; Region: PemK; pfam02452 246194001999 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246194002000 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246194002001 catalytic triad [active] 246194002002 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246194002003 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 246194002004 active site 246194002005 Response regulator receiver domain; Region: Response_reg; pfam00072 246194002006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002007 active site 246194002008 phosphorylation site [posttranslational modification] 246194002009 intermolecular recognition site; other site 246194002010 dimerization interface [polypeptide binding]; other site 246194002011 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 246194002012 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 246194002013 Glycoprotease family; Region: Peptidase_M22; pfam00814 246194002014 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246194002015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246194002016 Coenzyme A binding pocket [chemical binding]; other site 246194002017 UGMP family protein; Validated; Region: PRK09604 246194002018 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 246194002019 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 246194002020 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246194002021 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246194002022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002023 FeS/SAM binding site; other site 246194002024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246194002025 protein binding site [polypeptide binding]; other site 246194002026 Protein of unknown function (DUF512); Region: DUF512; pfam04459 246194002027 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 246194002028 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246194002029 acyl-activating enzyme (AAE) consensus motif; other site 246194002030 AMP binding site [chemical binding]; other site 246194002031 active site 246194002032 CoA binding site [chemical binding]; other site 246194002033 ACT domain-containing protein [General function prediction only]; Region: COG4747 246194002034 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 246194002035 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 246194002036 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 246194002037 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 246194002038 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 246194002039 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 246194002040 putative dimer interface [polypeptide binding]; other site 246194002041 [2Fe-2S] cluster binding site [ion binding]; other site 246194002042 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 246194002043 dimer interface [polypeptide binding]; other site 246194002044 [2Fe-2S] cluster binding site [ion binding]; other site 246194002045 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 246194002046 SLBB domain; Region: SLBB; pfam10531 246194002047 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 246194002048 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 246194002049 4Fe-4S binding domain; Region: Fer4; pfam00037 246194002050 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194002051 4Fe-4S binding domain; Region: Fer4; pfam00037 246194002052 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 246194002053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246194002054 catalytic loop [active] 246194002055 iron binding site [ion binding]; other site 246194002056 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 246194002057 4Fe-4S binding domain; Region: Fer4_6; pfam12837 246194002058 4Fe-4S binding domain; Region: Fer4; pfam00037 246194002059 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 246194002060 [4Fe-4S] binding site [ion binding]; other site 246194002061 molybdopterin cofactor binding site; other site 246194002062 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 246194002063 molybdopterin cofactor binding site; other site 246194002064 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 246194002065 active site 1 [active] 246194002066 dimer interface [polypeptide binding]; other site 246194002067 hexamer interface [polypeptide binding]; other site 246194002068 active site 2 [active] 246194002069 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 246194002070 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 246194002071 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 246194002072 ACS interaction site; other site 246194002073 CODH interaction site; other site 246194002074 cubane metal cluster (B-cluster) [ion binding]; other site 246194002075 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 246194002076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 246194002077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246194002078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194002079 Rubrerythrin [Energy production and conversion]; Region: COG1592 246194002080 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 246194002081 binuclear metal center [ion binding]; other site 246194002082 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 246194002083 iron binding site [ion binding]; other site 246194002084 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246194002085 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 246194002086 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 246194002087 catalytic residues [active] 246194002088 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 246194002089 Zn binding site [ion binding]; other site 246194002090 Uncharacterized conserved protein [Function unknown]; Region: COG1739 246194002091 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 246194002092 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246194002093 putative active site pocket [active] 246194002094 dimerization interface [polypeptide binding]; other site 246194002095 putative catalytic residue [active] 246194002096 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 246194002097 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 246194002098 thiamine phosphate binding site [chemical binding]; other site 246194002099 active site 246194002100 pyrophosphate binding site [ion binding]; other site 246194002101 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 246194002102 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 246194002103 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 246194002104 substrate binding site [chemical binding]; other site 246194002105 multimerization interface [polypeptide binding]; other site 246194002106 ATP binding site [chemical binding]; other site 246194002107 thiamine monophosphate kinase; Provisional; Region: PRK05731 246194002108 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 246194002109 ATP binding site [chemical binding]; other site 246194002110 dimerization interface [polypeptide binding]; other site 246194002111 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 246194002112 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 246194002113 putative active site [active] 246194002114 putative metal binding site [ion binding]; other site 246194002115 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 246194002116 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 246194002117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194002118 catalytic residue [active] 246194002119 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 246194002120 putative FMN binding site [chemical binding]; other site 246194002121 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 246194002122 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 246194002123 cobalt transport protein CbiM; Validated; Region: PRK08319 246194002124 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 246194002125 cobalt transport protein CbiN; Provisional; Region: PRK02898 246194002126 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 246194002127 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246194002128 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246194002129 Walker A/P-loop; other site 246194002130 ATP binding site [chemical binding]; other site 246194002131 Q-loop/lid; other site 246194002132 ABC transporter signature motif; other site 246194002133 Walker B; other site 246194002134 D-loop; other site 246194002135 H-loop/switch region; other site 246194002136 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 246194002137 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 246194002138 putative homodimer interface [polypeptide binding]; other site 246194002139 active site 246194002140 SAM binding site [chemical binding]; other site 246194002141 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 246194002142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194002143 S-adenosylmethionine binding site [chemical binding]; other site 246194002144 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 246194002145 active site 246194002146 SAM binding site [chemical binding]; other site 246194002147 homodimer interface [polypeptide binding]; other site 246194002148 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 246194002149 active site 246194002150 SAM binding site [chemical binding]; other site 246194002151 homodimer interface [polypeptide binding]; other site 246194002152 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 246194002153 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 246194002154 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 246194002155 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 246194002156 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 246194002157 active site 246194002158 SAM binding site [chemical binding]; other site 246194002159 homodimer interface [polypeptide binding]; other site 246194002160 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 246194002161 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 246194002162 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 246194002163 putative active site [active] 246194002164 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 246194002165 Precorrin-8X methylmutase; Region: CbiC; pfam02570 246194002166 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246194002167 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 246194002168 homotrimer interface [polypeptide binding]; other site 246194002169 Walker A motif; other site 246194002170 GTP binding site [chemical binding]; other site 246194002171 Walker B motif; other site 246194002172 cobyric acid synthase; Provisional; Region: PRK00784 246194002173 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 246194002174 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 246194002175 catalytic triad [active] 246194002176 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 246194002177 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 246194002178 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194002179 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 246194002180 catalytic triad [active] 246194002181 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 246194002182 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246194002183 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 246194002184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194002185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194002186 homodimer interface [polypeptide binding]; other site 246194002187 catalytic residue [active] 246194002188 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246194002189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246194002190 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246194002191 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 246194002192 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194002193 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 246194002194 active site 246194002195 SAM binding site [chemical binding]; other site 246194002196 homodimer interface [polypeptide binding]; other site 246194002197 cobalamin synthase; Reviewed; Region: cobS; PRK00235 246194002198 L-asparaginase II; Region: Asparaginase_II; pfam06089 246194002199 SurA N-terminal domain; Region: SurA_N_3; cl07813 246194002200 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246194002201 active site 246194002202 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 246194002203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194002204 dimer interface [polypeptide binding]; other site 246194002205 conserved gate region; other site 246194002206 putative PBP binding loops; other site 246194002207 ABC-ATPase subunit interface; other site 246194002208 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 246194002209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194002210 dimer interface [polypeptide binding]; other site 246194002211 conserved gate region; other site 246194002212 putative PBP binding loops; other site 246194002213 ABC-ATPase subunit interface; other site 246194002214 PBP superfamily domain; Region: PBP_like_2; cl17296 246194002215 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246194002216 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 246194002217 dimanganese center [ion binding]; other site 246194002218 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 246194002219 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 246194002220 putative active site [active] 246194002221 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 246194002222 GAF domain; Region: GAF; pfam01590 246194002223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194002224 putative active site [active] 246194002225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194002226 Walker A motif; other site 246194002227 ATP binding site [chemical binding]; other site 246194002228 Walker B motif; other site 246194002229 arginine finger; other site 246194002230 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194002231 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 246194002232 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 246194002233 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 246194002234 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 246194002235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002236 FeS/SAM binding site; other site 246194002237 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 246194002238 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246194002239 MoaE interaction surface [polypeptide binding]; other site 246194002240 MoeB interaction surface [polypeptide binding]; other site 246194002241 thiocarboxylated glycine; other site 246194002242 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 246194002243 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 246194002244 ATP binding site [chemical binding]; other site 246194002245 substrate interface [chemical binding]; other site 246194002246 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 246194002247 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 246194002248 [4Fe-4S] binding site [ion binding]; other site 246194002249 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194002250 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194002251 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 246194002252 molybdopterin cofactor binding site; other site 246194002253 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 246194002254 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194002255 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 246194002256 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 246194002257 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 246194002258 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 246194002259 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246194002260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246194002261 dimer interface [polypeptide binding]; other site 246194002262 putative functional site; other site 246194002263 putative MPT binding site; other site 246194002264 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 246194002265 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246194002266 dimer interface [polypeptide binding]; other site 246194002267 putative functional site; other site 246194002268 putative MPT binding site; other site 246194002269 PBP superfamily domain; Region: PBP_like; pfam12727 246194002270 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 246194002271 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 246194002272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002273 FeS/SAM binding site; other site 246194002274 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 246194002275 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 246194002276 trimer interface [polypeptide binding]; other site 246194002277 dimer interface [polypeptide binding]; other site 246194002278 putative active site [active] 246194002279 MOSC domain; Region: MOSC; pfam03473 246194002280 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 246194002281 MPT binding site; other site 246194002282 trimer interface [polypeptide binding]; other site 246194002283 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 246194002284 oligomerisation interface [polypeptide binding]; other site 246194002285 mobile loop; other site 246194002286 roof hairpin; other site 246194002287 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 246194002288 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246194002289 ring oligomerisation interface [polypeptide binding]; other site 246194002290 ATP/Mg binding site [chemical binding]; other site 246194002291 stacking interactions; other site 246194002292 hinge regions; other site 246194002293 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246194002294 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246194002295 dimer interface [polypeptide binding]; other site 246194002296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194002297 catalytic residue [active] 246194002298 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 246194002299 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246194002300 DNA binding site [nucleotide binding] 246194002301 active site 246194002302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 246194002303 Probable transposase; Region: OrfB_IS605; pfam01385 246194002304 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194002305 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 246194002306 MarR family; Region: MarR; pfam01047 246194002307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194002308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194002309 putative substrate translocation pore; other site 246194002310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194002311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194002312 putative substrate translocation pore; other site 246194002313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194002314 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 246194002315 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246194002316 active site 246194002317 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246194002318 active site 246194002319 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 246194002320 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 246194002321 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246194002322 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246194002323 putative dimer interface [polypeptide binding]; other site 246194002324 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246194002325 putative active site [active] 246194002326 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 246194002327 HsdM N-terminal domain; Region: HsdM_N; pfam12161 246194002328 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246194002329 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 246194002330 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 246194002331 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 246194002332 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 246194002333 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 246194002334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246194002335 ATP binding site [chemical binding]; other site 246194002336 putative Mg++ binding site [ion binding]; other site 246194002337 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 246194002338 Protein of unknown function DUF45; Region: DUF45; pfam01863 246194002339 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 246194002340 AAA domain; Region: AAA_25; pfam13481 246194002341 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246194002342 Walker A motif; other site 246194002343 ATP binding site [chemical binding]; other site 246194002344 Walker B motif; other site 246194002345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194002346 putative DNA binding site [nucleotide binding]; other site 246194002347 putative Zn2+ binding site [ion binding]; other site 246194002348 Homeodomain-like domain; Region: HTH_23; cl17451 246194002349 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246194002350 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246194002351 active site 246194002352 DNA binding site [nucleotide binding] 246194002353 Int/Topo IB signature motif; other site 246194002354 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 246194002355 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 246194002356 acyl-activating enzyme (AAE) consensus motif; other site 246194002357 putative AMP binding site [chemical binding]; other site 246194002358 putative active site [active] 246194002359 putative CoA binding site [chemical binding]; other site 246194002360 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 246194002361 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 246194002362 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 246194002363 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 246194002364 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246194002365 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 246194002366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194002367 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 246194002368 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 246194002369 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 246194002370 RNA/DNA hybrid binding site [nucleotide binding]; other site 246194002371 active site 246194002372 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246194002373 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 246194002374 Sodium Bile acid symporter family; Region: SBF; cl17470 246194002375 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 246194002376 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 246194002377 dimer interface [polypeptide binding]; other site 246194002378 active site residues [active] 246194002379 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 246194002380 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246194002381 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 246194002382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194002383 dimerization interface [polypeptide binding]; other site 246194002384 putative DNA binding site [nucleotide binding]; other site 246194002385 putative Zn2+ binding site [ion binding]; other site 246194002386 Heavy-metal-associated domain; Region: HMA; pfam00403 246194002387 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246194002388 metal-binding site [ion binding] 246194002389 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246194002390 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 246194002391 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246194002392 Peptidase family M23; Region: Peptidase_M23; pfam01551 246194002393 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 246194002394 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 246194002395 Amidohydrolase; Region: Amidohydro_4; pfam13147 246194002396 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246194002397 active site 246194002398 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 246194002399 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 246194002400 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 246194002401 GTP binding site; other site 246194002402 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246194002403 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246194002404 dimer interface [polypeptide binding]; other site 246194002405 putative functional site; other site 246194002406 putative MPT binding site; other site 246194002407 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 246194002408 Walker A motif; other site 246194002409 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194002410 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194002411 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194002412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194002413 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194002414 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 246194002415 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 246194002416 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246194002417 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246194002418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194002419 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246194002420 Walker A/P-loop; other site 246194002421 ATP binding site [chemical binding]; other site 246194002422 Q-loop/lid; other site 246194002423 ABC transporter signature motif; other site 246194002424 Walker B; other site 246194002425 D-loop; other site 246194002426 H-loop/switch region; other site 246194002427 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246194002428 HlyD family secretion protein; Region: HlyD_3; pfam13437 246194002429 Protein of unknown function (DUF1847); Region: DUF1847; cl02037 246194002430 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 246194002431 Pyruvate formate lyase; Region: PFL; pfam02901 246194002432 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 246194002433 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 246194002434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002435 FeS/SAM binding site; other site 246194002436 Response regulator receiver domain; Region: Response_reg; pfam00072 246194002437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002438 active site 246194002439 phosphorylation site [posttranslational modification] 246194002440 intermolecular recognition site; other site 246194002441 dimerization interface [polypeptide binding]; other site 246194002442 PAS domain S-box; Region: sensory_box; TIGR00229 246194002443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194002444 putative active site [active] 246194002445 heme pocket [chemical binding]; other site 246194002446 PAS domain S-box; Region: sensory_box; TIGR00229 246194002447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194002448 putative active site [active] 246194002449 heme pocket [chemical binding]; other site 246194002450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194002451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194002452 metal binding site [ion binding]; metal-binding site 246194002453 active site 246194002454 I-site; other site 246194002455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194002456 Zn2+ binding site [ion binding]; other site 246194002457 Mg2+ binding site [ion binding]; other site 246194002458 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194002459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194002460 Zn2+ binding site [ion binding]; other site 246194002461 Mg2+ binding site [ion binding]; other site 246194002462 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246194002463 KaiC; Region: KaiC; pfam06745 246194002464 Walker A motif; other site 246194002465 Walker A motif; other site 246194002466 ATP binding site [chemical binding]; other site 246194002467 Walker B motif; other site 246194002468 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002469 dimer interface [polypeptide binding]; other site 246194002470 putative CheW interface [polypeptide binding]; other site 246194002471 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 246194002472 active site 1 [active] 246194002473 dimer interface [polypeptide binding]; other site 246194002474 hexamer interface [polypeptide binding]; other site 246194002475 active site 2 [active] 246194002476 biotin synthase; Region: bioB; TIGR00433 246194002477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002478 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 246194002479 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246194002480 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246194002481 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 246194002482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246194002483 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 246194002484 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246194002485 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 246194002486 active site 246194002487 nucleophile elbow; other site 246194002488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002489 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246194002490 FeS/SAM binding site; other site 246194002491 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 246194002492 Uncharacterized conserved protein [Function unknown]; Region: COG3937 246194002493 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 246194002494 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 246194002495 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 246194002496 Walker A/P-loop; other site 246194002497 ATP binding site [chemical binding]; other site 246194002498 Q-loop/lid; other site 246194002499 ABC transporter signature motif; other site 246194002500 Walker B; other site 246194002501 D-loop; other site 246194002502 H-loop/switch region; other site 246194002503 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 246194002504 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246194002505 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246194002506 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 246194002507 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 246194002508 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 246194002509 tetramer interface [polypeptide binding]; other site 246194002510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194002511 catalytic residue [active] 246194002512 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194002513 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194002514 Zn2+ binding site [ion binding]; other site 246194002515 Mg2+ binding site [ion binding]; other site 246194002516 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246194002517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246194002518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194002519 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 246194002520 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 246194002521 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194002522 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 246194002523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246194002524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246194002525 DNA binding site [nucleotide binding] 246194002526 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 246194002527 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 246194002528 CoA-ligase; Region: Ligase_CoA; pfam00549 246194002529 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 246194002530 CoA binding domain; Region: CoA_binding; pfam02629 246194002531 CoA-ligase; Region: Ligase_CoA; pfam00549 246194002532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246194002533 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246194002534 dimer interface [polypeptide binding]; other site 246194002535 substrate binding site [chemical binding]; other site 246194002536 metal binding site [ion binding]; metal-binding site 246194002537 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 246194002538 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246194002539 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246194002540 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 246194002541 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246194002542 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246194002543 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246194002544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246194002545 carboxyltransferase (CT) interaction site; other site 246194002546 biotinylation site [posttranslational modification]; other site 246194002547 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246194002548 metal-dependent hydrolase; Provisional; Region: PRK00685 246194002549 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 246194002550 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 246194002551 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 246194002552 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 246194002553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246194002554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246194002555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246194002556 putative alcohol dehydrogenase; Provisional; Region: PRK09860 246194002557 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 246194002558 dimer interface [polypeptide binding]; other site 246194002559 active site 246194002560 metal binding site [ion binding]; metal-binding site 246194002561 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194002562 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 246194002563 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 246194002564 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194002565 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 246194002566 Cysteine-rich domain; Region: CCG; pfam02754 246194002567 Cysteine-rich domain; Region: CCG; pfam02754 246194002568 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 246194002569 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 246194002570 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 246194002571 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 246194002572 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 246194002573 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 246194002574 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 246194002575 FAD binding pocket [chemical binding]; other site 246194002576 FAD binding motif [chemical binding]; other site 246194002577 phosphate binding motif [ion binding]; other site 246194002578 beta-alpha-beta structure motif; other site 246194002579 NAD binding pocket [chemical binding]; other site 246194002580 Iron coordination center [ion binding]; other site 246194002581 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246194002582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194002583 putative active site [active] 246194002584 heme pocket [chemical binding]; other site 246194002585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194002586 dimer interface [polypeptide binding]; other site 246194002587 phosphorylation site [posttranslational modification] 246194002588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194002589 ATP binding site [chemical binding]; other site 246194002590 Mg2+ binding site [ion binding]; other site 246194002591 G-X-G motif; other site 246194002592 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 246194002593 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 246194002594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002595 FeS/SAM binding site; other site 246194002596 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 246194002597 putative homodimer interface [polypeptide binding]; other site 246194002598 putative homotetramer interface [polypeptide binding]; other site 246194002599 putative allosteric switch controlling residues; other site 246194002600 putative metal binding site [ion binding]; other site 246194002601 putative homodimer-homodimer interface [polypeptide binding]; other site 246194002602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246194002603 metal-binding site [ion binding] 246194002604 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246194002605 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246194002606 metal-binding site [ion binding] 246194002607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246194002608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246194002609 metal-binding site [ion binding] 246194002610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246194002611 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246194002612 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 246194002613 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 246194002614 NurA nuclease; Region: NurA; smart00933 246194002615 Domain of unknown function DUF87; Region: DUF87; pfam01935 246194002616 HerA helicase [Replication, recombination, and repair]; Region: COG0433 246194002617 Zonular occludens toxin (Zot); Region: Zot; cl17485 246194002618 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 246194002619 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246194002620 active site 246194002621 metal binding site [ion binding]; metal-binding site 246194002622 DNA binding site [nucleotide binding] 246194002623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194002624 AAA domain; Region: AAA_23; pfam13476 246194002625 Walker A/P-loop; other site 246194002626 ATP binding site [chemical binding]; other site 246194002627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194002628 Walker B; other site 246194002629 D-loop; other site 246194002630 H-loop/switch region; other site 246194002631 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194002632 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194002633 metal binding site [ion binding]; metal-binding site 246194002634 active site 246194002635 I-site; other site 246194002636 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 246194002637 active site 246194002638 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 246194002639 Ligand Binding Site [chemical binding]; other site 246194002640 Domain of unknown function (DUF366); Region: DUF366; pfam04017 246194002641 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 246194002642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194002643 FeS/SAM binding site; other site 246194002644 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 246194002645 homodecamer interface [polypeptide binding]; other site 246194002646 GTP cyclohydrolase I; Provisional; Region: PLN03044 246194002647 active site 246194002648 putative catalytic site residues [active] 246194002649 zinc binding site [ion binding]; other site 246194002650 GTP-CH-I/GFRP interaction surface; other site 246194002651 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 246194002652 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 246194002653 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 246194002654 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 246194002655 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246194002656 active site 246194002657 stage V sporulation protein B; Region: spore_V_B; TIGR02900 246194002658 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 246194002659 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 246194002660 elongation factor G; Reviewed; Region: PRK12740 246194002661 G1 box; other site 246194002662 putative GEF interaction site [polypeptide binding]; other site 246194002663 GTP/Mg2+ binding site [chemical binding]; other site 246194002664 Switch I region; other site 246194002665 G2 box; other site 246194002666 G3 box; other site 246194002667 Switch II region; other site 246194002668 G4 box; other site 246194002669 G5 box; other site 246194002670 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246194002671 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246194002672 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246194002673 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194002674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194002675 Zn2+ binding site [ion binding]; other site 246194002676 Mg2+ binding site [ion binding]; other site 246194002677 flagellar motor protein MotA; Validated; Region: PRK08124 246194002678 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 246194002679 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 246194002680 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 246194002681 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246194002682 ligand binding site [chemical binding]; other site 246194002683 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246194002684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194002685 dimerization interface [polypeptide binding]; other site 246194002686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002687 dimer interface [polypeptide binding]; other site 246194002688 putative CheW interface [polypeptide binding]; other site 246194002689 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 246194002690 putative CheA interaction surface; other site 246194002691 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 246194002692 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246194002693 putative binding surface; other site 246194002694 active site 246194002695 P2 response regulator binding domain; Region: P2; pfam07194 246194002696 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 246194002697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194002698 ATP binding site [chemical binding]; other site 246194002699 Mg2+ binding site [ion binding]; other site 246194002700 G-X-G motif; other site 246194002701 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 246194002702 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 246194002703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002704 active site 246194002705 phosphorylation site [posttranslational modification] 246194002706 intermolecular recognition site; other site 246194002707 dimerization interface [polypeptide binding]; other site 246194002708 CheB methylesterase; Region: CheB_methylest; pfam01339 246194002709 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 246194002710 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 246194002711 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 246194002712 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 246194002713 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 246194002714 FliW protein; Region: FliW; cl00740 246194002715 carbon storage regulator; Provisional; Region: PRK01712 246194002716 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 246194002717 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 246194002718 substrate binding site; other site 246194002719 metal-binding site 246194002720 Oligomer interface; other site 246194002721 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246194002722 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 246194002723 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 246194002724 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 246194002725 NADP binding site [chemical binding]; other site 246194002726 active site 246194002727 putative substrate binding site [chemical binding]; other site 246194002728 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 246194002729 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 246194002730 NAD binding site [chemical binding]; other site 246194002731 substrate binding site [chemical binding]; other site 246194002732 homodimer interface [polypeptide binding]; other site 246194002733 active site 246194002734 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 246194002735 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 246194002736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194002737 S-adenosylmethionine binding site [chemical binding]; other site 246194002738 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246194002739 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246194002740 Probable Catalytic site; other site 246194002741 metal-binding site 246194002742 flagellin; Provisional; Region: PRK12804 246194002743 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 246194002744 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 246194002745 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246194002746 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 246194002747 putative metal binding site; other site 246194002748 TPR repeat; Region: TPR_11; pfam13414 246194002749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246194002750 binding surface 246194002751 TPR motif; other site 246194002752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246194002753 binding surface 246194002754 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246194002755 TPR motif; other site 246194002756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246194002757 binding surface 246194002758 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246194002759 TPR motif; other site 246194002760 FlaG protein; Region: FlaG; pfam03646 246194002761 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 246194002762 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 246194002763 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 246194002764 Flagellar protein FliS; Region: FliS; cl00654 246194002765 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 246194002766 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 246194002767 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 246194002768 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 246194002769 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 246194002770 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 246194002771 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 246194002772 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 246194002773 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 246194002774 MgtE intracellular N domain; Region: MgtE_N; cl15244 246194002775 FliG C-terminal domain; Region: FliG_C; pfam01706 246194002776 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 246194002777 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246194002778 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 246194002779 Walker A motif/ATP binding site; other site 246194002780 Walker B motif; other site 246194002781 Flagellar FliJ protein; Region: FliJ; pfam02050 246194002782 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 246194002783 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 246194002784 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 246194002785 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 246194002786 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 246194002787 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 246194002788 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 246194002789 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 246194002790 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 246194002791 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 246194002792 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 246194002793 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 246194002794 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 246194002795 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 246194002796 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 246194002797 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 246194002798 FHIPEP family; Region: FHIPEP; pfam00771 246194002799 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 246194002800 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194002801 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246194002802 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 246194002803 P-loop; other site 246194002804 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 246194002805 Flagellar protein YcgR; Region: YcgR_2; pfam12945 246194002806 PilZ domain; Region: PilZ; pfam07238 246194002807 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 246194002808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194002809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194002810 DNA binding residues [nucleotide binding] 246194002811 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 246194002812 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 246194002813 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 246194002814 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 246194002815 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246194002816 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 246194002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194002818 S-adenosylmethionine binding site [chemical binding]; other site 246194002819 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 246194002820 CheC-like family; Region: CheC; pfam04509 246194002821 Response regulator receiver domain; Region: Response_reg; pfam00072 246194002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002823 active site 246194002824 phosphorylation site [posttranslational modification] 246194002825 intermolecular recognition site; other site 246194002826 dimerization interface [polypeptide binding]; other site 246194002827 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 246194002828 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 246194002829 flagellar motor switch protein; Validated; Region: PRK08119 246194002830 CheC-like family; Region: CheC; pfam04509 246194002831 CheC-like family; Region: CheC; pfam04509 246194002832 flagellar motor switch protein FliN; Region: fliN; TIGR02480 246194002833 Protein of unknown function (DUF342); Region: DUF342; pfam03961 246194002834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 246194002835 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 246194002836 Cache domain; Region: Cache_1; pfam02743 246194002837 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 246194002838 dimerization interface [polypeptide binding]; other site 246194002839 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246194002840 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002841 dimer interface [polypeptide binding]; other site 246194002842 putative CheW interface [polypeptide binding]; other site 246194002843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002844 putative CheW interface [polypeptide binding]; other site 246194002845 Response regulator receiver domain; Region: Response_reg; pfam00072 246194002846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002847 active site 246194002848 phosphorylation site [posttranslational modification] 246194002849 intermolecular recognition site; other site 246194002850 dimerization interface [polypeptide binding]; other site 246194002851 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 246194002852 HEAT repeats; Region: HEAT_2; pfam13646 246194002853 protein binding surface [polypeptide binding]; other site 246194002854 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246194002855 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 246194002856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194002857 S-adenosylmethionine binding site [chemical binding]; other site 246194002858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002859 dimer interface [polypeptide binding]; other site 246194002860 putative CheW interface [polypeptide binding]; other site 246194002861 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246194002862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002863 dimer interface [polypeptide binding]; other site 246194002864 putative CheW interface [polypeptide binding]; other site 246194002865 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 246194002866 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 246194002867 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 246194002868 putative CheA interaction surface; other site 246194002869 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 246194002870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002871 active site 246194002872 phosphorylation site [posttranslational modification] 246194002873 intermolecular recognition site; other site 246194002874 dimerization interface [polypeptide binding]; other site 246194002875 CheB methylesterase; Region: CheB_methylest; pfam01339 246194002876 Response regulator receiver domain; Region: Response_reg; pfam00072 246194002877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194002878 active site 246194002879 phosphorylation site [posttranslational modification] 246194002880 intermolecular recognition site; other site 246194002881 dimerization interface [polypeptide binding]; other site 246194002882 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246194002883 putative binding surface; other site 246194002884 active site 246194002885 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 246194002886 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 246194002887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194002888 ATP binding site [chemical binding]; other site 246194002889 Mg2+ binding site [ion binding]; other site 246194002890 G-X-G motif; other site 246194002891 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246194002892 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 246194002893 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 246194002894 Prephenate dehydratase; Region: PDT; pfam00800 246194002895 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 246194002896 Homeodomain-like domain; Region: HTH_23; cl17451 246194002897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194002898 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 246194002899 putative ADP-binding pocket [chemical binding]; other site 246194002900 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 246194002901 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 246194002902 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 246194002903 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 246194002904 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246194002905 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 246194002906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194002907 dimer interface [polypeptide binding]; other site 246194002908 putative CheW interface [polypeptide binding]; other site 246194002909 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 246194002910 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 246194002911 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246194002912 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246194002913 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246194002914 Ligand binding site; other site 246194002915 Putative Catalytic site; other site 246194002916 DXD motif; other site 246194002917 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 246194002918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246194002919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194002920 S-adenosylmethionine binding site [chemical binding]; other site 246194002921 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 246194002922 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194002923 putative homodimer interface [polypeptide binding]; other site 246194002924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194002925 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246194002926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194002927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246194002928 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246194002929 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246194002930 active site 246194002931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246194002932 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 246194002933 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 246194002934 NAD binding site [chemical binding]; other site 246194002935 substrate binding site [chemical binding]; other site 246194002936 homodimer interface [polypeptide binding]; other site 246194002937 active site 246194002938 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 246194002939 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 246194002940 putative ADP-binding pocket [chemical binding]; other site 246194002941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194002942 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 246194002943 Bacterial sugar transferase; Region: Bac_transf; pfam02397 246194002944 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 246194002945 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 246194002946 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 246194002947 Uncharacterized conserved protein [Function unknown]; Region: COG4198 246194002948 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 246194002949 homodimer interface [polypeptide binding]; other site 246194002950 metal binding site [ion binding]; metal-binding site 246194002951 Uncharacterized conserved protein [Function unknown]; Region: COG1751 246194002952 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 246194002953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194002954 active site 246194002955 GMP synthase; Reviewed; Region: guaA; PRK00074 246194002956 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 246194002957 AMP/PPi binding site [chemical binding]; other site 246194002958 candidate oxyanion hole; other site 246194002959 catalytic triad [active] 246194002960 potential glutamine specificity residues [chemical binding]; other site 246194002961 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 246194002962 ATP Binding subdomain [chemical binding]; other site 246194002963 Ligand Binding sites [chemical binding]; other site 246194002964 Dimerization subdomain; other site 246194002965 AIR carboxylase; Region: AIRC; pfam00731 246194002966 adenylosuccinate lyase; Provisional; Region: PRK07380 246194002967 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 246194002968 tetramer interface [polypeptide binding]; other site 246194002969 active site 246194002970 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 246194002971 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 246194002972 ATP binding site [chemical binding]; other site 246194002973 active site 246194002974 substrate binding site [chemical binding]; other site 246194002975 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 246194002976 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 246194002977 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 246194002978 putative active site [active] 246194002979 catalytic triad [active] 246194002980 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 246194002981 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 246194002982 dimerization interface [polypeptide binding]; other site 246194002983 ATP binding site [chemical binding]; other site 246194002984 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 246194002985 dimerization interface [polypeptide binding]; other site 246194002986 ATP binding site [chemical binding]; other site 246194002987 amidophosphoribosyltransferase; Provisional; Region: PRK05793 246194002988 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 246194002989 active site 246194002990 tetramer interface [polypeptide binding]; other site 246194002991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194002992 active site 246194002993 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 246194002994 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 246194002995 dimerization interface [polypeptide binding]; other site 246194002996 putative ATP binding site [chemical binding]; other site 246194002997 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 246194002998 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 246194002999 active site 246194003000 substrate binding site [chemical binding]; other site 246194003001 cosubstrate binding site; other site 246194003002 catalytic site [active] 246194003003 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 246194003004 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 246194003005 purine monophosphate binding site [chemical binding]; other site 246194003006 dimer interface [polypeptide binding]; other site 246194003007 putative catalytic residues [active] 246194003008 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 246194003009 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 246194003010 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 246194003011 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 246194003012 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 246194003013 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 246194003014 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 246194003015 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 246194003016 Ligand Binding Site [chemical binding]; other site 246194003017 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 246194003018 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 246194003019 Ligand Binding Site [chemical binding]; other site 246194003020 Trp repressor protein; Region: Trp_repressor; cl17266 246194003021 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 246194003022 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 246194003023 dimer interface [polypeptide binding]; other site 246194003024 motif 1; other site 246194003025 active site 246194003026 motif 2; other site 246194003027 motif 3; other site 246194003028 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 246194003029 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 246194003030 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246194003031 histidinol dehydrogenase; Region: hisD; TIGR00069 246194003032 NAD binding site [chemical binding]; other site 246194003033 dimerization interface [polypeptide binding]; other site 246194003034 product binding site; other site 246194003035 substrate binding site [chemical binding]; other site 246194003036 zinc binding site [ion binding]; other site 246194003037 catalytic residues [active] 246194003038 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 246194003039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194003040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194003041 homodimer interface [polypeptide binding]; other site 246194003042 catalytic residue [active] 246194003043 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 246194003044 putative active site pocket [active] 246194003045 4-fold oligomerization interface [polypeptide binding]; other site 246194003046 metal binding residues [ion binding]; metal-binding site 246194003047 3-fold/trimer interface [polypeptide binding]; other site 246194003048 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 246194003049 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 246194003050 putative active site [active] 246194003051 oxyanion strand; other site 246194003052 catalytic triad [active] 246194003053 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 246194003054 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 246194003055 catalytic residues [active] 246194003056 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 246194003057 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 246194003058 substrate binding site [chemical binding]; other site 246194003059 glutamase interaction surface [polypeptide binding]; other site 246194003060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 246194003061 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 246194003062 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 246194003063 metal binding site [ion binding]; metal-binding site 246194003064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194003065 dimerization interface [polypeptide binding]; other site 246194003066 putative DNA binding site [nucleotide binding]; other site 246194003067 putative Zn2+ binding site [ion binding]; other site 246194003068 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 246194003069 arsenical-resistance protein; Region: acr3; TIGR00832 246194003070 membrane protein; Provisional; Region: PRK14404 246194003071 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246194003072 catalytic residues [active] 246194003073 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 246194003074 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 246194003075 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 246194003076 Predicted permeases [General function prediction only]; Region: COG0701 246194003077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194003078 dimerization interface [polypeptide binding]; other site 246194003079 putative DNA binding site [nucleotide binding]; other site 246194003080 putative Zn2+ binding site [ion binding]; other site 246194003081 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 246194003082 Part of AAA domain; Region: AAA_19; pfam13245 246194003083 AAA domain; Region: AAA_14; pfam13173 246194003084 Family description; Region: UvrD_C_2; pfam13538 246194003085 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 246194003086 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 246194003087 nucleotide binding pocket [chemical binding]; other site 246194003088 K-X-D-G motif; other site 246194003089 catalytic site [active] 246194003090 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 246194003091 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 246194003092 Helix-hairpin-helix motif; Region: HHH; pfam00633 246194003093 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 246194003094 Dimer interface [polypeptide binding]; other site 246194003095 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 246194003096 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246194003097 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 246194003098 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 246194003099 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 246194003100 GatB domain; Region: GatB_Yqey; smart00845 246194003101 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 246194003102 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 246194003103 active site 246194003104 catalytic residues [active] 246194003105 metal binding site [ion binding]; metal-binding site 246194003106 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 246194003107 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 246194003108 substrate binding site [chemical binding]; other site 246194003109 ligand binding site [chemical binding]; other site 246194003110 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 246194003111 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 246194003112 substrate binding site [chemical binding]; other site 246194003113 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 246194003114 isocitrate dehydrogenase; Validated; Region: PRK06451 246194003115 CAAX protease self-immunity; Region: Abi; pfam02517 246194003116 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246194003117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246194003118 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246194003119 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 246194003120 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194003121 active site 246194003122 NTP binding site [chemical binding]; other site 246194003123 metal binding triad [ion binding]; metal-binding site 246194003124 antibiotic binding site [chemical binding]; other site 246194003125 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 246194003126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194003127 S-adenosylmethionine binding site [chemical binding]; other site 246194003128 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246194003129 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246194003130 MarR family; Region: MarR; pfam01047 246194003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194003132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194003133 putative substrate translocation pore; other site 246194003134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003135 Walker A motif; other site 246194003136 ATP binding site [chemical binding]; other site 246194003137 Walker B motif; other site 246194003138 Helix-turn-helix domain; Region: HTH_38; pfam13936 246194003139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246194003140 Integrase core domain; Region: rve; pfam00665 246194003141 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 246194003142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246194003143 active site 246194003144 catalytic tetrad [active] 246194003145 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246194003146 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246194003147 active site 246194003148 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246194003149 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 246194003150 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 246194003151 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246194003152 minor groove reading motif; other site 246194003153 helix-hairpin-helix signature motif; other site 246194003154 substrate binding pocket [chemical binding]; other site 246194003155 active site 246194003156 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 246194003157 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 246194003158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246194003159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194003160 dimer interface [polypeptide binding]; other site 246194003161 phosphorylation site [posttranslational modification] 246194003162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194003163 ATP binding site [chemical binding]; other site 246194003164 Mg2+ binding site [ion binding]; other site 246194003165 G-X-G motif; other site 246194003166 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 246194003167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194003168 active site 246194003169 phosphorylation site [posttranslational modification] 246194003170 intermolecular recognition site; other site 246194003171 dimerization interface [polypeptide binding]; other site 246194003172 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 246194003173 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246194003174 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246194003175 Walker A/P-loop; other site 246194003176 ATP binding site [chemical binding]; other site 246194003177 Q-loop/lid; other site 246194003178 ABC transporter signature motif; other site 246194003179 Walker B; other site 246194003180 D-loop; other site 246194003181 H-loop/switch region; other site 246194003182 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 246194003183 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 246194003184 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246194003185 Walker A/P-loop; other site 246194003186 ATP binding site [chemical binding]; other site 246194003187 Q-loop/lid; other site 246194003188 ABC transporter signature motif; other site 246194003189 Walker B; other site 246194003190 D-loop; other site 246194003191 H-loop/switch region; other site 246194003192 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 246194003193 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 246194003194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 246194003195 peptide binding site [polypeptide binding]; other site 246194003196 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246194003197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194003198 dimer interface [polypeptide binding]; other site 246194003199 conserved gate region; other site 246194003200 putative PBP binding loops; other site 246194003201 ABC-ATPase subunit interface; other site 246194003202 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 246194003203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194003204 dimer interface [polypeptide binding]; other site 246194003205 conserved gate region; other site 246194003206 putative PBP binding loops; other site 246194003207 ABC-ATPase subunit interface; other site 246194003208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246194003209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003210 Walker A motif; other site 246194003211 ATP binding site [chemical binding]; other site 246194003212 Walker B motif; other site 246194003213 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246194003214 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246194003215 metal ion-dependent adhesion site (MIDAS); other site 246194003216 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 246194003217 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 246194003218 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 246194003219 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246194003220 metal binding site 2 [ion binding]; metal-binding site 246194003221 putative DNA binding helix; other site 246194003222 metal binding site 1 [ion binding]; metal-binding site 246194003223 dimer interface [polypeptide binding]; other site 246194003224 structural Zn2+ binding site [ion binding]; other site 246194003225 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 246194003226 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246194003227 DNA-binding site [nucleotide binding]; DNA binding site 246194003228 DRTGG domain; Region: DRTGG; pfam07085 246194003229 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 246194003230 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 246194003231 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 246194003232 active site 246194003233 PHP Thumb interface [polypeptide binding]; other site 246194003234 metal binding site [ion binding]; metal-binding site 246194003235 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246194003236 generic binding surface I; other site 246194003237 generic binding surface II; other site 246194003238 transcription attenuation protein MtrB; Provisional; Region: PRK13251 246194003239 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 246194003240 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 246194003241 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246194003242 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 246194003243 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 246194003244 6-phosphofructokinase; Provisional; Region: PRK03202 246194003245 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 246194003246 active site 246194003247 ADP/pyrophosphate binding site [chemical binding]; other site 246194003248 dimerization interface [polypeptide binding]; other site 246194003249 allosteric effector site; other site 246194003250 fructose-1,6-bisphosphate binding site; other site 246194003251 pyruvate kinase; Provisional; Region: PRK06354 246194003252 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 246194003253 domain interfaces; other site 246194003254 active site 246194003255 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 246194003256 Late competence development protein ComFB; Region: ComFB; pfam10719 246194003257 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 246194003258 NodB motif; other site 246194003259 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 246194003260 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246194003261 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246194003262 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246194003263 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246194003264 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 246194003265 dihydrodipicolinate reductase; Provisional; Region: PRK00048 246194003266 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246194003267 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 246194003268 dipicolinic acid synthetase, A subunit; Region: spore_dpaA; TIGR02853 246194003269 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 246194003270 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 246194003271 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 246194003272 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 246194003273 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 246194003274 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246194003275 aspartate kinase I; Reviewed; Region: PRK08210 246194003276 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 246194003277 nucleotide binding site [chemical binding]; other site 246194003278 substrate binding site [chemical binding]; other site 246194003279 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 246194003280 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246194003281 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 246194003282 dihydrodipicolinate synthase; Region: dapA; TIGR00674 246194003283 dimer interface [polypeptide binding]; other site 246194003284 active site 246194003285 catalytic residue [active] 246194003286 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 246194003287 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194003288 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 246194003289 Bacitracin resistance protein BacA; Region: BacA; pfam02673 246194003290 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246194003291 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246194003292 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 246194003293 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 246194003294 germination protein YpeB; Region: spore_YpeB; TIGR02889 246194003295 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 246194003296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246194003297 active site residue [active] 246194003298 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 246194003299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194003300 non-specific DNA binding site [nucleotide binding]; other site 246194003301 salt bridge; other site 246194003302 sequence-specific DNA binding site [nucleotide binding]; other site 246194003303 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 246194003304 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246194003305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194003306 FeS/SAM binding site; other site 246194003307 Competence-damaged protein; Region: CinA; pfam02464 246194003308 recombinase A; Provisional; Region: recA; PRK09354 246194003309 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 246194003310 hexamer interface [polypeptide binding]; other site 246194003311 Walker A motif; other site 246194003312 ATP binding site [chemical binding]; other site 246194003313 Walker B motif; other site 246194003314 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 246194003315 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 246194003316 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 246194003317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194003318 Zn2+ binding site [ion binding]; other site 246194003319 Mg2+ binding site [ion binding]; other site 246194003320 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 246194003321 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246194003322 putative active site [active] 246194003323 metal binding site [ion binding]; metal-binding site 246194003324 homodimer binding site [polypeptide binding]; other site 246194003325 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 246194003326 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 246194003327 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 246194003328 active site 246194003329 dimer interface [polypeptide binding]; other site 246194003330 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 246194003331 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194003332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194003333 homodimer interface [polypeptide binding]; other site 246194003334 catalytic residue [active] 246194003335 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 246194003336 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 246194003337 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 246194003338 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246194003339 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 246194003340 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246194003341 active site 246194003342 MoxR-like ATPases [General function prediction only]; Region: COG0714 246194003343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003344 Walker A motif; other site 246194003345 ATP binding site [chemical binding]; other site 246194003346 Walker B motif; other site 246194003347 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 246194003348 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246194003349 metal ion-dependent adhesion site (MIDAS); other site 246194003350 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 246194003351 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246194003352 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 246194003353 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 246194003354 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 246194003355 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246194003356 nucleotide binding site [chemical binding]; other site 246194003357 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246194003358 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 246194003359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246194003360 NAD(P) binding site [chemical binding]; other site 246194003361 active site 246194003362 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246194003363 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 246194003364 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194003365 active site 246194003366 NTP binding site [chemical binding]; other site 246194003367 metal binding triad [ion binding]; metal-binding site 246194003368 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 246194003369 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 246194003370 Nitrogen regulatory protein P-II; Region: P-II; smart00938 246194003371 Nitrogen regulatory protein P-II; Region: P-II; smart00938 246194003372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 246194003373 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 246194003374 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 246194003375 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 246194003376 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 246194003377 SpoVR like protein; Region: SpoVR; pfam04293 246194003378 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 246194003379 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 246194003380 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194003381 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246194003382 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246194003383 substrate binding pocket [chemical binding]; other site 246194003384 chain length determination region; other site 246194003385 substrate-Mg2+ binding site; other site 246194003386 catalytic residues [active] 246194003387 aspartate-rich region 1; other site 246194003388 active site lid residues [active] 246194003389 aspartate-rich region 2; other site 246194003390 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 246194003391 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 246194003392 tRNA; other site 246194003393 putative tRNA binding site [nucleotide binding]; other site 246194003394 putative NADP binding site [chemical binding]; other site 246194003395 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 246194003396 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 246194003397 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 246194003398 domain interfaces; other site 246194003399 active site 246194003400 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 246194003401 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246194003402 active site 246194003403 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 246194003404 dimer interface [polypeptide binding]; other site 246194003405 active site 246194003406 Schiff base residues; other site 246194003407 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 246194003408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194003409 FeS/SAM binding site; other site 246194003410 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246194003411 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 246194003412 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246194003413 inhibitor-cofactor binding pocket; inhibition site 246194003414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194003415 catalytic residue [active] 246194003416 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246194003417 ABC1 family; Region: ABC1; cl17513 246194003418 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 246194003419 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194003420 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 246194003421 Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917 246194003422 CODH interaction site; other site 246194003423 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 246194003424 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 246194003425 Putative Fe-S cluster; Region: FeS; pfam04060 246194003426 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246194003427 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 246194003428 catalytic loop [active] 246194003429 iron binding site [ion binding]; other site 246194003430 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 246194003431 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 246194003432 P-loop; other site 246194003433 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194003434 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 246194003435 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 246194003436 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 246194003437 substrate binding pocket [chemical binding]; other site 246194003438 dimer interface [polypeptide binding]; other site 246194003439 inhibitor binding site; inhibition site 246194003440 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 246194003441 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 246194003442 Cysteine-rich domain; Region: CCG; pfam02754 246194003443 Cysteine-rich domain; Region: CCG; pfam02754 246194003444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246194003445 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 246194003446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246194003447 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 246194003448 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 246194003449 4Fe-4S binding domain; Region: Fer4; pfam00037 246194003450 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 246194003451 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 246194003452 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 246194003453 FAD binding site [chemical binding]; other site 246194003454 histidinol-phosphatase; Provisional; Region: PRK07328 246194003455 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 246194003456 active site 246194003457 dimer interface [polypeptide binding]; other site 246194003458 Helix-turn-helix domain; Region: HTH_36; pfam13730 246194003459 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 246194003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003461 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246194003462 Walker A motif; other site 246194003463 ATP binding site [chemical binding]; other site 246194003464 Walker B motif; other site 246194003465 arginine finger; other site 246194003466 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 246194003467 ABC1 family; Region: ABC1; cl17513 246194003468 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246194003469 active site 246194003470 ATP binding site [chemical binding]; other site 246194003471 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 246194003472 Uncharacterized conserved protein [Function unknown]; Region: COG2006 246194003473 4Fe-4S binding domain; Region: Fer4; cl02805 246194003474 4Fe-4S binding domain; Region: Fer4_6; pfam12837 246194003475 spermidine synthase; Provisional; Region: PRK00811 246194003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194003477 S-adenosylmethionine binding site [chemical binding]; other site 246194003478 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 246194003479 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 246194003480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 246194003481 Integrase core domain; Region: rve; pfam00665 246194003482 Integrase core domain; Region: rve_3; pfam13683 246194003483 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 246194003484 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 246194003485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003486 Walker A motif; other site 246194003487 ATP binding site [chemical binding]; other site 246194003488 Walker B motif; other site 246194003489 arginine finger; other site 246194003490 Propionate catabolism activator; Region: PrpR_N; pfam06506 246194003491 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 246194003492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194003493 putative active site [active] 246194003494 heme pocket [chemical binding]; other site 246194003495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003496 Walker A motif; other site 246194003497 ATP binding site [chemical binding]; other site 246194003498 Walker B motif; other site 246194003499 arginine finger; other site 246194003500 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194003501 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 246194003502 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 246194003503 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 246194003504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 246194003505 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 246194003506 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 246194003507 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 246194003508 thiS-thiF/thiG interaction site; other site 246194003509 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 246194003510 ThiS interaction site; other site 246194003511 putative active site [active] 246194003512 tetramer interface [polypeptide binding]; other site 246194003513 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 246194003514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194003515 FeS/SAM binding site; other site 246194003516 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 246194003517 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 246194003518 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 246194003519 ATP binding site [chemical binding]; other site 246194003520 substrate interface [chemical binding]; other site 246194003521 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 246194003522 thiamine phosphate binding site [chemical binding]; other site 246194003523 active site 246194003524 pyrophosphate binding site [ion binding]; other site 246194003525 Uncharacterized conserved protein [Function unknown]; Region: COG1416 246194003526 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 246194003527 TatD related DNase; Region: TatD_DNase; pfam01026 246194003528 active site 246194003529 glycerate kinase; Region: TIGR00045 246194003530 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 246194003531 benzoate transporter; Region: benE; TIGR00843 246194003532 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246194003533 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246194003534 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 246194003535 active site 246194003536 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 246194003537 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246194003538 Bacterial transcriptional regulator; Region: IclR; pfam01614 246194003539 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 246194003540 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194003541 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 246194003542 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 246194003543 active site 246194003544 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cd00758 246194003545 MPT binding site; other site 246194003546 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 246194003547 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 246194003548 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246194003549 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 246194003550 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 246194003551 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 246194003552 active site 246194003553 catalytic residues [active] 246194003554 metal binding site [ion binding]; metal-binding site 246194003555 DmpG-like communication domain; Region: DmpG_comm; pfam07836 246194003556 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 246194003557 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 246194003558 Ligand Binding Site [chemical binding]; other site 246194003559 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 246194003560 AIR carboxylase; Region: AIRC; smart01001 246194003561 hypothetical protein; Provisional; Region: PRK04194 246194003562 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 246194003563 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 246194003564 trimer interface [polypeptide binding]; other site 246194003565 active site 246194003566 putative acyltransferase; Provisional; Region: PRK05790 246194003567 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246194003568 dimer interface [polypeptide binding]; other site 246194003569 active site 246194003570 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 246194003571 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 246194003572 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246194003573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246194003574 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246194003575 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 246194003576 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246194003577 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246194003578 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 246194003579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246194003580 substrate binding site [chemical binding]; other site 246194003581 oxyanion hole (OAH) forming residues; other site 246194003582 trimer interface [polypeptide binding]; other site 246194003583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194003584 dimerization interface [polypeptide binding]; other site 246194003585 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246194003586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194003587 dimer interface [polypeptide binding]; other site 246194003588 putative CheW interface [polypeptide binding]; other site 246194003589 FAD binding domain; Region: FAD_binding_4; pfam01565 246194003590 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246194003591 FAD binding domain; Region: FAD_binding_4; pfam01565 246194003592 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246194003593 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194003594 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194003595 Cysteine-rich domain; Region: CCG; pfam02754 246194003596 Cysteine-rich domain; Region: CCG; pfam02754 246194003597 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 246194003598 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 246194003599 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 246194003600 DctM-like transporters; Region: DctM; pfam06808 246194003601 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 246194003602 recA bacterial DNA recombination protein; Region: RecA; cl17211 246194003603 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 246194003604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246194003605 classical (c) SDRs; Region: SDR_c; cd05233 246194003606 NAD(P) binding site [chemical binding]; other site 246194003607 active site 246194003608 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246194003609 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246194003610 NAD(P) binding site [chemical binding]; other site 246194003611 Probable molybdopterin binding domain; Region: MoCF_biosynth; smart00852 246194003612 MPT binding site; other site 246194003613 Ferredoxin [Energy production and conversion]; Region: COG1146 246194003614 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194003615 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 246194003616 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246194003617 dimer interface [polypeptide binding]; other site 246194003618 PYR/PP interface [polypeptide binding]; other site 246194003619 TPP binding site [chemical binding]; other site 246194003620 substrate binding site [chemical binding]; other site 246194003621 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246194003622 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 246194003623 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 246194003624 TPP-binding site [chemical binding]; other site 246194003625 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 246194003626 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 246194003627 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 246194003628 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 246194003629 Uncharacterized conserved protein [Function unknown]; Region: COG2006 246194003630 PAS domain S-box; Region: sensory_box; TIGR00229 246194003631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194003632 putative active site [active] 246194003633 heme pocket [chemical binding]; other site 246194003634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003635 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246194003636 Walker A motif; other site 246194003637 ATP binding site [chemical binding]; other site 246194003638 Walker B motif; other site 246194003639 arginine finger; other site 246194003640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194003641 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 246194003642 active site 246194003643 substrate binding site [chemical binding]; other site 246194003644 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 246194003645 FMN binding site [chemical binding]; other site 246194003646 putative catalytic residues [active] 246194003647 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246194003648 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246194003649 inhibitor site; inhibition site 246194003650 active site 246194003651 dimer interface [polypeptide binding]; other site 246194003652 catalytic residue [active] 246194003653 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246194003654 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 246194003655 transmembrane helices; other site 246194003656 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 246194003657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194003658 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246194003659 FAD binding site [chemical binding]; other site 246194003660 homotetramer interface [polypeptide binding]; other site 246194003661 substrate binding pocket [chemical binding]; other site 246194003662 catalytic base [active] 246194003663 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 246194003664 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 246194003665 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 246194003666 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246194003667 Ligand binding site [chemical binding]; other site 246194003668 Electron transfer flavoprotein domain; Region: ETF; pfam01012 246194003669 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246194003670 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246194003671 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246194003672 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 246194003673 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194003674 4Fe-4S binding domain; Region: Fer4; cl02805 246194003675 Cysteine-rich domain; Region: CCG; pfam02754 246194003676 Cysteine-rich domain; Region: CCG; pfam02754 246194003677 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246194003678 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246194003679 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 246194003680 active site 246194003681 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 246194003682 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 246194003683 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 246194003684 Protein of unknown function (DUF917); Region: DUF917; pfam06032 246194003685 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246194003686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003687 Walker A motif; other site 246194003688 ATP binding site [chemical binding]; other site 246194003689 Walker B motif; other site 246194003690 arginine finger; other site 246194003691 Homeodomain-like domain; Region: HTH_23; pfam13384 246194003692 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246194003693 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 246194003694 Na binding site [ion binding]; other site 246194003695 Protein of unknown function (DUF917); Region: DUF917; pfam06032 246194003696 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 246194003697 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 246194003698 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 246194003699 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 246194003700 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 246194003701 active site 246194003702 8-oxo-dGMP binding site [chemical binding]; other site 246194003703 nudix motif; other site 246194003704 metal binding site [ion binding]; metal-binding site 246194003705 adenylate kinase; Reviewed; Region: adk; PRK00279 246194003706 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 246194003707 AMP-binding site [chemical binding]; other site 246194003708 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 246194003709 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246194003710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194003711 S-adenosylmethionine binding site [chemical binding]; other site 246194003712 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 246194003713 Nuclease-related domain; Region: NERD; pfam08378 246194003714 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246194003715 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246194003716 active site 246194003717 ATP binding site [chemical binding]; other site 246194003718 substrate binding site [chemical binding]; other site 246194003719 activation loop (A-loop); other site 246194003720 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246194003721 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246194003722 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 246194003723 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 246194003724 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246194003725 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 246194003726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194003727 ABC transporter signature motif; other site 246194003728 Walker B; other site 246194003729 D-loop; other site 246194003730 H-loop/switch region; other site 246194003731 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 246194003732 phosphofructokinase; Region: PFK_mixed; TIGR02483 246194003733 active site 246194003734 ADP/pyrophosphate binding site [chemical binding]; other site 246194003735 dimerization interface [polypeptide binding]; other site 246194003736 allosteric effector site; other site 246194003737 fructose-1,6-bisphosphate binding site; other site 246194003738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194003739 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246194003740 FAD binding site [chemical binding]; other site 246194003741 homotetramer interface [polypeptide binding]; other site 246194003742 substrate binding pocket [chemical binding]; other site 246194003743 catalytic base [active] 246194003744 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 246194003745 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 246194003746 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 246194003747 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246194003748 Ligand binding site [chemical binding]; other site 246194003749 Electron transfer flavoprotein domain; Region: ETF; pfam01012 246194003750 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246194003751 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246194003752 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246194003753 putative acyltransferase; Provisional; Region: PRK05790 246194003754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246194003755 dimer interface [polypeptide binding]; other site 246194003756 active site 246194003757 Protein of unknown function (DUF523); Region: DUF523; pfam04463 246194003758 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 246194003759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194003760 FeS/SAM binding site; other site 246194003761 pyrophosphatase PpaX; Provisional; Region: PRK13288 246194003762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246194003763 motif II; other site 246194003764 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 246194003765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194003766 putative active site [active] 246194003767 PAS domain; Region: PAS; smart00091 246194003768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003769 Walker A motif; other site 246194003770 ATP binding site [chemical binding]; other site 246194003771 Walker B motif; other site 246194003772 arginine finger; other site 246194003773 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 246194003774 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 246194003775 Catalytic site [active] 246194003776 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 246194003777 4Fe-4S binding domain; Region: Fer4; pfam00037 246194003778 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 246194003779 coenzyme F420-reducing hydrogenase subunit beta; Validated; Region: PRK09325 246194003780 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 246194003781 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 246194003782 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 246194003783 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 246194003784 DctM-like transporters; Region: DctM; pfam06808 246194003785 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 246194003786 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 246194003787 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 246194003788 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 246194003789 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 246194003790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194003791 active site 246194003792 phosphorylation site [posttranslational modification] 246194003793 intermolecular recognition site; other site 246194003794 dimerization interface [polypeptide binding]; other site 246194003795 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 246194003796 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 246194003797 Malic enzyme, N-terminal domain; Region: malic; pfam00390 246194003798 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 246194003799 putative NAD(P) binding site [chemical binding]; other site 246194003800 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 246194003801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246194003802 catalytic loop [active] 246194003803 iron binding site [ion binding]; other site 246194003804 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 246194003805 putative Iron-sulfur protein interface [polypeptide binding]; other site 246194003806 putative proximal heme binding site [chemical binding]; other site 246194003807 putative SdhC-like subunit interface [polypeptide binding]; other site 246194003808 putative distal heme binding site [chemical binding]; other site 246194003809 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 246194003810 putative Iron-sulfur protein interface [polypeptide binding]; other site 246194003811 putative proximal heme binding site [chemical binding]; other site 246194003812 putative SdhD-like interface [polypeptide binding]; other site 246194003813 putative distal heme binding site [chemical binding]; other site 246194003814 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06069 246194003815 L-aspartate oxidase; Provisional; Region: PRK06175 246194003816 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246194003817 Fumarase C-terminus; Region: Fumerase_C; cl00795 246194003818 fumarate hydratase; Provisional; Region: PRK06246 246194003819 PAS domain S-box; Region: sensory_box; TIGR00229 246194003820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194003821 putative active site [active] 246194003822 heme pocket [chemical binding]; other site 246194003823 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 246194003824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003825 Walker A motif; other site 246194003826 ATP binding site [chemical binding]; other site 246194003827 Walker B motif; other site 246194003828 arginine finger; other site 246194003829 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194003830 LexA repressor; Validated; Region: PRK00215 246194003831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194003832 putative DNA binding site [nucleotide binding]; other site 246194003833 putative Zn2+ binding site [ion binding]; other site 246194003834 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 246194003835 Catalytic site [active] 246194003836 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 246194003837 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 246194003838 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246194003839 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246194003840 Walker A/P-loop; other site 246194003841 ATP binding site [chemical binding]; other site 246194003842 Q-loop/lid; other site 246194003843 ABC transporter signature motif; other site 246194003844 Walker B; other site 246194003845 D-loop; other site 246194003846 H-loop/switch region; other site 246194003847 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 246194003848 CcmE; Region: CcmE; cl00994 246194003849 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 246194003850 Aluminium resistance protein; Region: Alum_res; pfam06838 246194003851 stage V sporulation protein K; Region: spore_V_K; TIGR02881 246194003852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194003853 Walker A motif; other site 246194003854 ATP binding site [chemical binding]; other site 246194003855 Walker B motif; other site 246194003856 arginine finger; other site 246194003857 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246194003858 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246194003859 active site 246194003860 metal binding site [ion binding]; metal-binding site 246194003861 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 246194003862 NodB motif; other site 246194003863 putative active site [active] 246194003864 putative catalytic site [active] 246194003865 Zn binding site [ion binding]; other site 246194003866 bacterial Hfq-like; Region: Hfq; cd01716 246194003867 hexamer interface [polypeptide binding]; other site 246194003868 Sm1 motif; other site 246194003869 RNA binding site [nucleotide binding]; other site 246194003870 Sm2 motif; other site 246194003871 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 246194003872 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 246194003873 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 246194003874 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 246194003875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194003876 ATP binding site [chemical binding]; other site 246194003877 Mg2+ binding site [ion binding]; other site 246194003878 G-X-G motif; other site 246194003879 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 246194003880 ATP binding site [chemical binding]; other site 246194003881 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 246194003882 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 246194003883 MutS domain I; Region: MutS_I; pfam01624 246194003884 MutS domain II; Region: MutS_II; pfam05188 246194003885 MutS domain III; Region: MutS_III; pfam05192 246194003886 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 246194003887 Walker A/P-loop; other site 246194003888 ATP binding site [chemical binding]; other site 246194003889 Q-loop/lid; other site 246194003890 ABC transporter signature motif; other site 246194003891 Walker B; other site 246194003892 D-loop; other site 246194003893 H-loop/switch region; other site 246194003894 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 246194003895 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246194003896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194003897 FeS/SAM binding site; other site 246194003898 TRAM domain; Region: TRAM; pfam01938 246194003899 Domain of unknown function (DUF892); Region: DUF892; cl17410 246194003900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246194003901 Spore germination protein; Region: Spore_permease; cl17796 246194003902 septum formation inhibitor; Reviewed; Region: minC; PRK00513 246194003903 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 246194003904 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 246194003905 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 246194003906 dimer interface [polypeptide binding]; other site 246194003907 ADP-ribose binding site [chemical binding]; other site 246194003908 active site 246194003909 nudix motif; other site 246194003910 metal binding site [ion binding]; metal-binding site 246194003911 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 246194003912 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 246194003913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 246194003914 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 246194003915 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246194003916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194003917 dimerization interface [polypeptide binding]; other site 246194003918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194003919 dimer interface [polypeptide binding]; other site 246194003920 phosphorylation site [posttranslational modification] 246194003921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 246194003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194003923 ATP binding site [chemical binding]; other site 246194003924 Mg2+ binding site [ion binding]; other site 246194003925 G-X-G motif; other site 246194003926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246194003927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194003928 active site 246194003929 phosphorylation site [posttranslational modification] 246194003930 intermolecular recognition site; other site 246194003931 dimerization interface [polypeptide binding]; other site 246194003932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246194003933 DNA binding site [nucleotide binding] 246194003934 hypothetical protein; Reviewed; Region: PRK12497 246194003935 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 246194003936 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246194003937 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 246194003938 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246194003939 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 246194003940 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246194003941 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246194003942 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 246194003943 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 246194003944 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 246194003945 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 246194003946 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 246194003947 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194003948 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 246194003949 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 246194003950 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 246194003951 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 246194003952 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 246194003953 NADH dehydrogenase subunit B; Validated; Region: PRK06411 246194003954 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 246194003955 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 246194003956 RNA/DNA hybrid binding site [nucleotide binding]; other site 246194003957 active site 246194003958 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 246194003959 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 246194003960 GTP/Mg2+ binding site [chemical binding]; other site 246194003961 G4 box; other site 246194003962 G5 box; other site 246194003963 G1 box; other site 246194003964 Switch I region; other site 246194003965 G2 box; other site 246194003966 G3 box; other site 246194003967 Switch II region; other site 246194003968 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 246194003969 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 246194003970 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 246194003971 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 246194003972 RimM N-terminal domain; Region: RimM; pfam01782 246194003973 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 246194003974 hypothetical protein; Provisional; Region: PRK00468 246194003975 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 246194003976 signal recognition particle protein; Provisional; Region: PRK10867 246194003977 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 246194003978 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 246194003979 P loop; other site 246194003980 GTP binding site [chemical binding]; other site 246194003981 Signal peptide binding domain; Region: SRP_SPB; pfam02978 246194003982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194003983 DNA binding residues [nucleotide binding] 246194003984 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 246194003985 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246194003986 inhibitor-cofactor binding pocket; inhibition site 246194003987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194003988 catalytic residue [active] 246194003989 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 246194003990 PUA domain; Region: PUA; cl00607 246194003991 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 246194003992 putative RNA binding site [nucleotide binding]; other site 246194003993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194003994 S-adenosylmethionine binding site [chemical binding]; other site 246194003995 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 246194003996 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 246194003997 active site 246194003998 putative substrate binding pocket [chemical binding]; other site 246194003999 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 246194004000 intersubunit interface [polypeptide binding]; other site 246194004001 active site 246194004002 Zn2+ binding site [ion binding]; other site 246194004003 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 246194004004 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 246194004005 homotetramer interface [polypeptide binding]; other site 246194004006 ligand binding site [chemical binding]; other site 246194004007 catalytic site [active] 246194004008 NAD binding site [chemical binding]; other site 246194004009 5'-methylthioadenosine phosphorylase; Validated; Region: PRK08666 246194004010 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 246194004011 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 246194004012 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 246194004013 P loop; other site 246194004014 GTP binding site [chemical binding]; other site 246194004015 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246194004016 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246194004017 Walker A/P-loop; other site 246194004018 ATP binding site [chemical binding]; other site 246194004019 Q-loop/lid; other site 246194004020 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 246194004021 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246194004022 ABC transporter signature motif; other site 246194004023 Walker B; other site 246194004024 D-loop; other site 246194004025 H-loop/switch region; other site 246194004026 ribonuclease III; Reviewed; Region: rnc; PRK00102 246194004027 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 246194004028 dimerization interface [polypeptide binding]; other site 246194004029 active site 246194004030 metal binding site [ion binding]; metal-binding site 246194004031 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 246194004032 dsRNA binding site [nucleotide binding]; other site 246194004033 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 246194004034 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246194004035 dimer interface [polypeptide binding]; other site 246194004036 active site 246194004037 acyl carrier protein; Provisional; Region: acpP; PRK00982 246194004038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246194004039 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 246194004040 NAD(P) binding site [chemical binding]; other site 246194004041 homotetramer interface [polypeptide binding]; other site 246194004042 homodimer interface [polypeptide binding]; other site 246194004043 active site 246194004044 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246194004045 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246194004046 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 246194004047 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246194004048 FMN binding site [chemical binding]; other site 246194004049 substrate binding site [chemical binding]; other site 246194004050 putative catalytic residue [active] 246194004051 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 246194004052 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 246194004053 dimer interface [polypeptide binding]; other site 246194004054 active site 246194004055 CoA binding pocket [chemical binding]; other site 246194004056 putative phosphate acyltransferase; Provisional; Region: PRK05331 246194004057 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 246194004058 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 246194004059 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 246194004060 active site 2 [active] 246194004061 active site 1 [active] 246194004062 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 246194004063 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 246194004064 propionate/acetate kinase; Provisional; Region: PRK12379 246194004065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246194004066 nucleotide binding site [chemical binding]; other site 246194004067 butyrate kinase; Provisional; Region: PRK03011 246194004068 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 246194004069 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 246194004070 Nucleoside recognition; Region: Gate; pfam07670 246194004071 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 246194004072 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 246194004073 active site 246194004074 (T/H)XGH motif; other site 246194004075 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 246194004076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194004077 S-adenosylmethionine binding site [chemical binding]; other site 246194004078 Flagellin N-methylase; Region: FliB; pfam03692 246194004079 germination protease; Provisional; Region: PRK12362 246194004080 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 246194004081 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 246194004082 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 246194004083 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 246194004084 ssDNA binding site; other site 246194004085 generic binding surface II; other site 246194004086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246194004087 ATP binding site [chemical binding]; other site 246194004088 putative Mg++ binding site [ion binding]; other site 246194004089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246194004090 nucleotide binding region [chemical binding]; other site 246194004091 ATP-binding site [chemical binding]; other site 246194004092 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246194004093 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 246194004094 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 246194004095 dimerization interface [polypeptide binding]; other site 246194004096 domain crossover interface; other site 246194004097 redox-dependent activation switch; other site 246194004098 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 246194004099 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 246194004100 active site 246194004101 metal binding site [ion binding]; metal-binding site 246194004102 homotetramer interface [polypeptide binding]; other site 246194004103 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 246194004104 homopentamer interface [polypeptide binding]; other site 246194004105 active site 246194004106 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 246194004107 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 246194004108 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246194004109 dimerization interface [polypeptide binding]; other site 246194004110 active site 246194004111 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 246194004112 Lumazine binding domain; Region: Lum_binding; pfam00677 246194004113 Lumazine binding domain; Region: Lum_binding; pfam00677 246194004114 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 246194004115 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 246194004116 catalytic motif [active] 246194004117 Zn binding site [ion binding]; other site 246194004118 RibD C-terminal domain; Region: RibD_C; cl17279 246194004119 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 246194004120 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 246194004121 substrate binding site [chemical binding]; other site 246194004122 hexamer interface [polypeptide binding]; other site 246194004123 metal binding site [ion binding]; metal-binding site 246194004124 GTPase RsgA; Reviewed; Region: PRK00098 246194004125 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 246194004126 RNA binding site [nucleotide binding]; other site 246194004127 homodimer interface [polypeptide binding]; other site 246194004128 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 246194004129 GTPase/Zn-binding domain interface [polypeptide binding]; other site 246194004130 GTP/Mg2+ binding site [chemical binding]; other site 246194004131 G4 box; other site 246194004132 G5 box; other site 246194004133 G1 box; other site 246194004134 Switch I region; other site 246194004135 G2 box; other site 246194004136 G3 box; other site 246194004137 Switch II region; other site 246194004138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246194004139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246194004140 active site 246194004141 ATP binding site [chemical binding]; other site 246194004142 substrate binding site [chemical binding]; other site 246194004143 activation loop (A-loop); other site 246194004144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 246194004145 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246194004146 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246194004147 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 246194004148 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246194004149 Protein phosphatase 2C; Region: PP2C; pfam00481 246194004150 active site 246194004151 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 246194004152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194004153 FeS/SAM binding site; other site 246194004154 16S rRNA methyltransferase B; Provisional; Region: PRK14902 246194004155 NusB family; Region: NusB; pfam01029 246194004156 putative RNA binding site [nucleotide binding]; other site 246194004157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194004158 S-adenosylmethionine binding site [chemical binding]; other site 246194004159 Protein of unknown function DUF116; Region: DUF116; pfam01976 246194004160 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 246194004161 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 246194004162 putative active site [active] 246194004163 substrate binding site [chemical binding]; other site 246194004164 putative cosubstrate binding site; other site 246194004165 catalytic site [active] 246194004166 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 246194004167 substrate binding site [chemical binding]; other site 246194004168 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 246194004169 active site 246194004170 catalytic residues [active] 246194004171 metal binding site [ion binding]; metal-binding site 246194004172 primosome assembly protein PriA; Validated; Region: PRK05580 246194004173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246194004174 ATP binding site [chemical binding]; other site 246194004175 putative Mg++ binding site [ion binding]; other site 246194004176 helicase superfamily c-terminal domain; Region: HELICc; smart00490 246194004177 ATP-binding site [chemical binding]; other site 246194004178 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 246194004179 Flavoprotein; Region: Flavoprotein; pfam02441 246194004180 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 246194004181 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 246194004182 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 246194004183 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 246194004184 catalytic site [active] 246194004185 G-X2-G-X-G-K; other site 246194004186 hypothetical protein; Provisional; Region: PRK04323 246194004187 hypothetical protein; Provisional; Region: PRK11820 246194004188 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 246194004189 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 246194004190 aspartate aminotransferase; Provisional; Region: PRK05764 246194004191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194004192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194004193 homodimer interface [polypeptide binding]; other site 246194004194 catalytic residue [active] 246194004195 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 246194004196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194004197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194004198 homodimer interface [polypeptide binding]; other site 246194004199 catalytic residue [active] 246194004200 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 246194004201 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246194004202 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246194004203 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 246194004204 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246194004205 Domain of unknown function (DUF814); Region: DUF814; pfam05670 246194004206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194004207 active site 246194004208 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 246194004209 active site 246194004210 dimer interface [polypeptide binding]; other site 246194004211 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 246194004212 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 246194004213 heterodimer interface [polypeptide binding]; other site 246194004214 active site 246194004215 FMN binding site [chemical binding]; other site 246194004216 homodimer interface [polypeptide binding]; other site 246194004217 substrate binding site [chemical binding]; other site 246194004218 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 246194004219 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 246194004220 FAD binding pocket [chemical binding]; other site 246194004221 FAD binding motif [chemical binding]; other site 246194004222 phosphate binding motif [ion binding]; other site 246194004223 beta-alpha-beta structure motif; other site 246194004224 NAD binding pocket [chemical binding]; other site 246194004225 Iron coordination center [ion binding]; other site 246194004226 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 246194004227 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246194004228 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246194004229 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 246194004230 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246194004231 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246194004232 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 246194004233 IMP binding site; other site 246194004234 dimer interface [polypeptide binding]; other site 246194004235 interdomain contacts; other site 246194004236 partial ornithine binding site; other site 246194004237 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 246194004238 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 246194004239 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 246194004240 catalytic site [active] 246194004241 subunit interface [polypeptide binding]; other site 246194004242 dihydroorotase; Validated; Region: pyrC; PRK09357 246194004243 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246194004244 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 246194004245 active site 246194004246 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 246194004247 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246194004248 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246194004249 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 246194004250 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194004251 active site 246194004252 Bifunctional nuclease; Region: DNase-RNase; pfam02577 246194004253 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246194004254 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194004255 RNA binding surface [nucleotide binding]; other site 246194004256 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246194004257 active site 246194004258 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 246194004259 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 246194004260 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 246194004261 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 246194004262 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 246194004263 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 246194004264 Protein export membrane protein; Region: SecD_SecF; pfam02355 246194004265 protein-export membrane protein SecD; Region: secD; TIGR01129 246194004266 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 246194004267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194004268 Zn2+ binding site [ion binding]; other site 246194004269 Mg2+ binding site [ion binding]; other site 246194004270 Preprotein translocase subunit; Region: YajC; pfam02699 246194004271 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 246194004272 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 246194004273 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 246194004274 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 246194004275 Stage II sporulation protein; Region: SpoIID; pfam08486 246194004276 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 246194004277 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 246194004278 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 246194004279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194004280 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 246194004281 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 246194004282 Ligand Binding Site [chemical binding]; other site 246194004283 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 246194004284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194004285 Walker A motif; other site 246194004286 ATP binding site [chemical binding]; other site 246194004287 Walker B motif; other site 246194004288 arginine finger; other site 246194004289 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 246194004290 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 246194004291 RuvA N terminal domain; Region: RuvA_N; pfam01330 246194004292 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 246194004293 active site 246194004294 putative DNA-binding cleft [nucleotide binding]; other site 246194004295 dimer interface [polypeptide binding]; other site 246194004296 hypothetical protein; Validated; Region: PRK00110 246194004297 NAD synthetase; Provisional; Region: PRK13980 246194004298 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 246194004299 homodimer interface [polypeptide binding]; other site 246194004300 NAD binding pocket [chemical binding]; other site 246194004301 ATP binding pocket [chemical binding]; other site 246194004302 Mg binding site [ion binding]; other site 246194004303 active-site loop [active] 246194004304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246194004305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246194004306 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 246194004307 putative dimerization interface [polypeptide binding]; other site 246194004308 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 246194004309 DAK2 domain; Region: Dak2; pfam02734 246194004310 EDD domain protein, DegV family; Region: DegV; TIGR00762 246194004311 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 246194004312 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246194004313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194004314 RNA binding surface [nucleotide binding]; other site 246194004315 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 246194004316 active site 246194004317 uracil binding [chemical binding]; other site 246194004318 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246194004319 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246194004320 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246194004321 catalytic residue [active] 246194004322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246194004323 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 246194004324 TM-ABC transporter signature motif; other site 246194004325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246194004326 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 246194004327 TM-ABC transporter signature motif; other site 246194004328 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 246194004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194004330 Walker A/P-loop; other site 246194004331 ATP binding site [chemical binding]; other site 246194004332 Q-loop/lid; other site 246194004333 ABC transporter signature motif; other site 246194004334 Walker B; other site 246194004335 D-loop; other site 246194004336 H-loop/switch region; other site 246194004337 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246194004338 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 246194004339 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 246194004340 ligand binding site [chemical binding]; other site 246194004341 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 246194004342 dimerization interface [polypeptide binding]; other site 246194004343 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 246194004344 ATP binding site [chemical binding]; other site 246194004345 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 246194004346 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 246194004347 HupF/HypC family; Region: HupF_HypC; pfam01455 246194004348 Acylphosphatase; Region: Acylphosphatase; pfam00708 246194004349 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 246194004350 HypF finger; Region: zf-HYPF; pfam07503 246194004351 HypF finger; Region: zf-HYPF; pfam07503 246194004352 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 246194004353 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194004354 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 246194004355 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 246194004356 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 246194004357 putative substrate-binding site; other site 246194004358 nickel binding site [ion binding]; other site 246194004359 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 246194004360 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 246194004361 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 246194004362 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 246194004363 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 246194004364 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 246194004365 4Fe-4S binding domain; Region: Fer4_6; pfam12837 246194004366 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246194004367 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194004368 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 246194004369 Putative Fe-S cluster; Region: FeS; cl17515 246194004370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194004371 Walker A motif; other site 246194004372 ATP binding site [chemical binding]; other site 246194004373 Walker B motif; other site 246194004374 arginine finger; other site 246194004375 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194004376 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 246194004377 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 246194004378 G1 box; other site 246194004379 GTP/Mg2+ binding site [chemical binding]; other site 246194004380 Switch I region; other site 246194004381 G2 box; other site 246194004382 Switch II region; other site 246194004383 G3 box; other site 246194004384 G4 box; other site 246194004385 G5 box; other site 246194004386 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 246194004387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194004388 FeS/SAM binding site; other site 246194004389 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 246194004390 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 246194004391 intersubunit interface [polypeptide binding]; other site 246194004392 active site 246194004393 catalytic residue [active] 246194004394 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 246194004395 active site 246194004396 catalytic motif [active] 246194004397 Zn binding site [ion binding]; other site 246194004398 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 246194004399 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246194004400 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246194004401 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 246194004402 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 246194004403 intersubunit interface [polypeptide binding]; other site 246194004404 active site 246194004405 Zn2+ binding site [ion binding]; other site 246194004406 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 246194004407 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 246194004408 sporulation protein YunB; Region: spo_yunB; TIGR02832 246194004409 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 246194004410 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 246194004411 active site 246194004412 HIGH motif; other site 246194004413 dimer interface [polypeptide binding]; other site 246194004414 KMSKS motif; other site 246194004415 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194004416 RNA binding surface [nucleotide binding]; other site 246194004417 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 246194004418 Transglycosylase; Region: Transgly; pfam00912 246194004419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246194004420 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 246194004421 MutS domain III; Region: MutS_III; pfam05192 246194004422 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 246194004423 Walker A/P-loop; other site 246194004424 ATP binding site [chemical binding]; other site 246194004425 Q-loop/lid; other site 246194004426 ABC transporter signature motif; other site 246194004427 Walker B; other site 246194004428 D-loop; other site 246194004429 H-loop/switch region; other site 246194004430 Smr domain; Region: Smr; pfam01713 246194004431 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 246194004432 Peptidase family U32; Region: Peptidase_U32; pfam01136 246194004433 Collagenase; Region: DUF3656; pfam12392 246194004434 Peptidase family U32; Region: Peptidase_U32; pfam01136 246194004435 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 246194004436 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 246194004437 active site 246194004438 DNA binding site [nucleotide binding] 246194004439 DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796 246194004440 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 246194004441 metal binding triad [ion binding]; metal-binding site 246194004442 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 246194004443 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 246194004444 active site 246194004445 Cell division protein ZapA; Region: ZapA; cl01146 246194004446 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 246194004447 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 246194004448 putative tRNA-binding site [nucleotide binding]; other site 246194004449 B3/4 domain; Region: B3_4; pfam03483 246194004450 tRNA synthetase B5 domain; Region: B5; smart00874 246194004451 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 246194004452 dimer interface [polypeptide binding]; other site 246194004453 motif 1; other site 246194004454 motif 3; other site 246194004455 motif 2; other site 246194004456 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 246194004457 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 246194004458 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 246194004459 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 246194004460 dimer interface [polypeptide binding]; other site 246194004461 motif 1; other site 246194004462 active site 246194004463 motif 2; other site 246194004464 motif 3; other site 246194004465 YqzL-like protein; Region: YqzL; pfam14006 246194004466 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 246194004467 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 246194004468 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246194004469 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 246194004470 TrkA-N domain; Region: TrkA_N; pfam02254 246194004471 TrkA-C domain; Region: TrkA_C; pfam02080 246194004472 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 246194004473 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 246194004474 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 246194004475 23S rRNA binding site [nucleotide binding]; other site 246194004476 L21 binding site [polypeptide binding]; other site 246194004477 L13 binding site [polypeptide binding]; other site 246194004478 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 246194004479 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 246194004480 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 246194004481 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 246194004482 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 246194004483 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 246194004484 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 246194004485 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 246194004486 active site 246194004487 dimer interface [polypeptide binding]; other site 246194004488 motif 1; other site 246194004489 motif 2; other site 246194004490 motif 3; other site 246194004491 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 246194004492 anticodon binding site; other site 246194004493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 246194004494 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 246194004495 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 246194004496 substrate binding site [chemical binding]; other site 246194004497 active site 246194004498 catalytic residues [active] 246194004499 heterodimer interface [polypeptide binding]; other site 246194004500 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 246194004501 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 246194004502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194004503 catalytic residue [active] 246194004504 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 246194004505 active site 246194004506 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 246194004507 active site 246194004508 ribulose/triose binding site [chemical binding]; other site 246194004509 phosphate binding site [ion binding]; other site 246194004510 substrate (anthranilate) binding pocket [chemical binding]; other site 246194004511 product (indole) binding pocket [chemical binding]; other site 246194004512 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 246194004513 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246194004514 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246194004515 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 246194004516 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 246194004517 glutamine binding [chemical binding]; other site 246194004518 catalytic triad [active] 246194004519 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 246194004520 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 246194004521 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246194004522 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 246194004523 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 246194004524 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 246194004525 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 246194004526 polysaccharide deacetylase family sporulation protein PdaB; Region: spore_ybaN_pdaB; TIGR02764 246194004527 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 246194004528 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 246194004529 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 246194004530 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 246194004531 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 246194004532 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 246194004533 putative valine binding site [chemical binding]; other site 246194004534 dimer interface [polypeptide binding]; other site 246194004535 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 246194004536 Uncharacterized conserved protein [Function unknown]; Region: COG0398 246194004537 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246194004538 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 246194004539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194004540 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 246194004541 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194004542 4Fe-4S binding domain; Region: Fer4; cl02805 246194004543 Cysteine-rich domain; Region: CCG; pfam02754 246194004544 Cysteine-rich domain; Region: CCG; pfam02754 246194004545 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246194004546 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246194004547 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246194004548 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246194004549 Ligand binding site [chemical binding]; other site 246194004550 Electron transfer flavoprotein domain; Region: ETF; pfam01012 246194004551 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 246194004552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246194004553 substrate binding site [chemical binding]; other site 246194004554 oxyanion hole (OAH) forming residues; other site 246194004555 trimer interface [polypeptide binding]; other site 246194004556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194004557 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246194004558 FAD binding site [chemical binding]; other site 246194004559 homotetramer interface [polypeptide binding]; other site 246194004560 substrate binding pocket [chemical binding]; other site 246194004561 catalytic base [active] 246194004562 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 246194004563 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246194004564 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246194004565 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 246194004566 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246194004567 dimer interface [polypeptide binding]; other site 246194004568 active site 246194004569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246194004570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246194004571 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 246194004572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246194004573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194004574 active site 246194004575 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 246194004576 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246194004577 dimer interface [polypeptide binding]; other site 246194004578 active site 246194004579 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246194004580 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246194004581 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246194004582 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246194004583 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246194004584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246194004585 substrate binding site [chemical binding]; other site 246194004586 oxyanion hole (OAH) forming residues; other site 246194004587 trimer interface [polypeptide binding]; other site 246194004588 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246194004589 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 246194004590 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 246194004591 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 246194004592 acyl-activating enzyme (AAE) consensus motif; other site 246194004593 putative AMP binding site [chemical binding]; other site 246194004594 putative active site [active] 246194004595 putative CoA binding site [chemical binding]; other site 246194004596 LysE type translocator; Region: LysE; cl00565 246194004597 agmatinase; Region: agmatinase; TIGR01230 246194004598 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 246194004599 putative active site [active] 246194004600 Mn binding site [ion binding]; other site 246194004601 spermidine synthase; Provisional; Region: PRK00811 246194004602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194004603 S-adenosylmethionine binding site [chemical binding]; other site 246194004604 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 246194004605 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 246194004606 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246194004607 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 246194004608 Uncharacterized conserved protein [Function unknown]; Region: COG0585 246194004609 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 246194004610 active site 246194004611 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 246194004612 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 246194004613 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246194004614 acyl-CoA synthetase; Validated; Region: PRK08162 246194004615 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 246194004616 acyl-activating enzyme (AAE) consensus motif; other site 246194004617 putative active site [active] 246194004618 AMP binding site [chemical binding]; other site 246194004619 putative CoA binding site [chemical binding]; other site 246194004620 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 246194004621 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246194004622 Walker A/P-loop; other site 246194004623 ATP binding site [chemical binding]; other site 246194004624 Q-loop/lid; other site 246194004625 ABC transporter signature motif; other site 246194004626 Walker B; other site 246194004627 D-loop; other site 246194004628 H-loop/switch region; other site 246194004629 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 246194004630 PDGLE domain; Region: PDGLE; pfam13190 246194004631 cobalt transport protein CbiM; Validated; Region: PRK06265 246194004632 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 246194004633 Transglycosylase; Region: Transgly; pfam00912 246194004634 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 246194004635 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246194004636 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 246194004637 Phospholipid methyltransferase; Region: PEMT; cl17370 246194004638 BioY family; Region: BioY; pfam02632 246194004639 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 246194004640 Staphylococcal nuclease homologues; Region: SNc; smart00318 246194004641 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 246194004642 Catalytic site; other site 246194004643 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 246194004644 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246194004645 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246194004646 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246194004647 catalytic residue [active] 246194004648 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 246194004649 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 246194004650 CoA-binding site [chemical binding]; other site 246194004651 ATP-binding [chemical binding]; other site 246194004652 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 246194004653 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 246194004654 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 246194004655 DNA binding site [nucleotide binding] 246194004656 catalytic residue [active] 246194004657 H2TH interface [polypeptide binding]; other site 246194004658 putative catalytic residues [active] 246194004659 turnover-facilitating residue; other site 246194004660 intercalation triad [nucleotide binding]; other site 246194004661 8OG recognition residue [nucleotide binding]; other site 246194004662 putative reading head residues; other site 246194004663 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246194004664 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246194004665 DNA polymerase I; Provisional; Region: PRK05755 246194004666 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246194004667 active site 246194004668 metal binding site 1 [ion binding]; metal-binding site 246194004669 putative 5' ssDNA interaction site; other site 246194004670 metal binding site 3; metal-binding site 246194004671 metal binding site 2 [ion binding]; metal-binding site 246194004672 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246194004673 putative DNA binding site [nucleotide binding]; other site 246194004674 putative metal binding site [ion binding]; other site 246194004675 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 246194004676 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 246194004677 active site 246194004678 DNA binding site [nucleotide binding] 246194004679 catalytic site [active] 246194004680 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246194004681 active site 246194004682 DNA polymerase IV; Validated; Region: PRK02406 246194004683 DNA binding site [nucleotide binding] 246194004684 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 246194004685 lysogenic bacteriophage; target tRNA-Leu-3 246194004686 attL/R 246194004687 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246194004688 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 246194004689 amidase catalytic site [active] 246194004690 Zn binding residues [ion binding]; other site 246194004691 substrate binding site [chemical binding]; other site 246194004692 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246194004693 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 246194004694 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 246194004695 Minor capsid protein; Region: Minor_capsid_1; pfam10665 246194004696 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 246194004697 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 246194004698 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 246194004699 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 246194004700 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 246194004701 Phage terminase large subunit; Region: Terminase_3; cl12054 246194004702 Terminase-like family; Region: Terminase_6; pfam03237 246194004703 Terminase small subunit; Region: Terminase_2; pfam03592 246194004704 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 246194004705 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 246194004706 Recombination protein U; Region: RecU; cl01314 246194004707 hypothetical protein; Provisional; Region: PRK06921 246194004708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194004709 Walker A motif; other site 246194004710 ATP binding site [chemical binding]; other site 246194004711 Walker B motif; other site 246194004712 arginine finger; other site 246194004713 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 246194004714 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 246194004715 RecT family; Region: RecT; pfam03837 246194004716 Helix-turn-helix domain; Region: HTH_17; pfam12728 246194004717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194004718 non-specific DNA binding site [nucleotide binding]; other site 246194004719 salt bridge; other site 246194004720 sequence-specific DNA binding site [nucleotide binding]; other site 246194004721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246194004722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194004723 non-specific DNA binding site [nucleotide binding]; other site 246194004724 salt bridge; other site 246194004725 sequence-specific DNA binding site [nucleotide binding]; other site 246194004726 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246194004727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194004728 non-specific DNA binding site [nucleotide binding]; other site 246194004729 salt bridge; other site 246194004730 sequence-specific DNA binding site [nucleotide binding]; other site 246194004731 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 246194004732 Catalytic site [active] 246194004733 Staphylococcal nuclease homologues; Region: SNc; smart00318 246194004734 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 246194004735 Catalytic site; other site 246194004736 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 246194004737 Staphylococcal nuclease homologues; Region: SNc; smart00318 246194004738 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 246194004739 Catalytic site; other site 246194004740 Restriction endonuclease; Region: Mrr_cat; pfam04471 246194004741 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 246194004742 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 246194004743 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 246194004744 Int/Topo IB signature motif; other site 246194004745 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 246194004746 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 246194004747 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 246194004748 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 246194004749 DNA binding residues [nucleotide binding] 246194004750 putative dimer interface [polypeptide binding]; other site 246194004751 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 246194004752 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 246194004753 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 246194004754 dimer interface [polypeptide binding]; other site 246194004755 active site 246194004756 metal binding site [ion binding]; metal-binding site 246194004757 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 246194004758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194004759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194004760 DNA binding residues [nucleotide binding] 246194004761 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 246194004762 Ubiquitin-like proteins; Region: UBQ; cl00155 246194004763 charged pocket; other site 246194004764 hydrophobic patch; other site 246194004765 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 246194004766 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 246194004767 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 246194004768 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 246194004769 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194004770 HEPN domain; Region: HEPN; pfam05168 246194004771 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 246194004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 246194004773 Walker A/P-loop; other site 246194004774 ATP binding site [chemical binding]; other site 246194004775 Q-loop/lid; other site 246194004776 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 246194004777 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 246194004778 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 246194004779 PIN domain; Region: PIN_3; pfam13470 246194004780 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 246194004781 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 246194004782 catalytic residues [active] 246194004783 CAAX protease self-immunity; Region: Abi; pfam02517 246194004784 Uncharacterized conserved protein [Function unknown]; Region: COG1700 246194004785 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 246194004786 Protein of unknown function (DUF524); Region: DUF524; pfam04411 246194004787 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 246194004788 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 246194004789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246194004790 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246194004791 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246194004792 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246194004793 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246194004794 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246194004795 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 246194004796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246194004797 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 246194004798 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 246194004799 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 246194004800 acyl-activating enzyme (AAE) consensus motif; other site 246194004801 putative AMP binding site [chemical binding]; other site 246194004802 putative active site [active] 246194004803 putative CoA binding site [chemical binding]; other site 246194004804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194004805 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246194004806 FAD binding site [chemical binding]; other site 246194004807 homotetramer interface [polypeptide binding]; other site 246194004808 substrate binding pocket [chemical binding]; other site 246194004809 catalytic base [active] 246194004810 Uncharacterized conserved protein [Function unknown]; Region: COG2006 246194004811 Domain of unknown function (DUF362); Region: DUF362; pfam04015 246194004812 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 246194004813 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 246194004814 acyl-activating enzyme (AAE) consensus motif; other site 246194004815 putative active site [active] 246194004816 putative AMP binding site [chemical binding]; other site 246194004817 putative CoA binding site [chemical binding]; other site 246194004818 enoyl-CoA hydratase; Provisional; Region: PRK09245 246194004819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246194004820 substrate binding site [chemical binding]; other site 246194004821 oxyanion hole (OAH) forming residues; other site 246194004822 trimer interface [polypeptide binding]; other site 246194004823 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194004824 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246194004825 active site 246194004826 putative acyltransferase; Provisional; Region: PRK05790 246194004827 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246194004828 dimer interface [polypeptide binding]; other site 246194004829 active site 246194004830 enoyl-CoA hydratase; Provisional; Region: PRK07658 246194004831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246194004832 substrate binding site [chemical binding]; other site 246194004833 oxyanion hole (OAH) forming residues; other site 246194004834 trimer interface [polypeptide binding]; other site 246194004835 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246194004836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194004837 S-adenosylmethionine binding site [chemical binding]; other site 246194004838 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246194004839 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 246194004840 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 246194004841 DUF35 OB-fold domain; Region: DUF35; pfam01796 246194004842 hypothetical protein; Provisional; Region: PRK04262 246194004843 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 246194004844 dimer interface [polypeptide binding]; other site 246194004845 active site 246194004846 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 246194004847 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 246194004848 active site 246194004849 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246194004850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246194004851 active site 246194004852 Transcriptional regulator [Transcription]; Region: IclR; COG1414 246194004853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194004854 putative Zn2+ binding site [ion binding]; other site 246194004855 putative DNA binding site [nucleotide binding]; other site 246194004856 Bacterial transcriptional regulator; Region: IclR; pfam01614 246194004857 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246194004858 MoaE interaction surface [polypeptide binding]; other site 246194004859 MoeB interaction surface [polypeptide binding]; other site 246194004860 thiocarboxylated glycine; other site 246194004861 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 246194004862 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 246194004863 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 246194004864 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246194004865 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 246194004866 active site 246194004867 NAD binding site [chemical binding]; other site 246194004868 metal binding site [ion binding]; metal-binding site 246194004869 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246194004870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246194004871 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246194004872 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246194004873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194004874 Walker A/P-loop; other site 246194004875 ATP binding site [chemical binding]; other site 246194004876 Q-loop/lid; other site 246194004877 ABC transporter signature motif; other site 246194004878 Walker B; other site 246194004879 D-loop; other site 246194004880 H-loop/switch region; other site 246194004881 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 246194004882 Pyrimidine 5'-nucleotidase (UMPH-1); Region: UMPH-1; pfam05822 246194004883 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 246194004884 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 246194004885 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246194004886 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 246194004887 endonuclease IV; Provisional; Region: PRK01060 246194004888 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 246194004889 AP (apurinic/apyrimidinic) site pocket; other site 246194004890 DNA interaction; other site 246194004891 Metal-binding active site; metal-binding site 246194004892 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 246194004893 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 246194004894 RNase E interface [polypeptide binding]; other site 246194004895 trimer interface [polypeptide binding]; other site 246194004896 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 246194004897 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 246194004898 RNase E interface [polypeptide binding]; other site 246194004899 trimer interface [polypeptide binding]; other site 246194004900 active site 246194004901 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 246194004902 putative nucleic acid binding region [nucleotide binding]; other site 246194004903 G-X-X-G motif; other site 246194004904 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 246194004905 RNA binding site [nucleotide binding]; other site 246194004906 domain interface; other site 246194004907 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 246194004908 16S/18S rRNA binding site [nucleotide binding]; other site 246194004909 S13e-L30e interaction site [polypeptide binding]; other site 246194004910 25S rRNA binding site [nucleotide binding]; other site 246194004911 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 246194004912 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 246194004913 active site 246194004914 Riboflavin kinase; Region: Flavokinase; pfam01687 246194004915 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 246194004916 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 246194004917 RNA binding site [nucleotide binding]; other site 246194004918 active site 246194004919 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 246194004920 DHH family; Region: DHH; pfam01368 246194004921 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 246194004922 translation initiation factor IF-2; Validated; Region: infB; PRK05306 246194004923 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246194004924 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246194004925 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 246194004926 G1 box; other site 246194004927 putative GEF interaction site [polypeptide binding]; other site 246194004928 GTP/Mg2+ binding site [chemical binding]; other site 246194004929 Switch I region; other site 246194004930 G2 box; other site 246194004931 G3 box; other site 246194004932 Switch II region; other site 246194004933 G4 box; other site 246194004934 G5 box; other site 246194004935 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 246194004936 Translation-initiation factor 2; Region: IF-2; pfam11987 246194004937 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 246194004938 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 246194004939 Protein of unknown function (DUF448); Region: DUF448; pfam04296 246194004940 putative RNA binding cleft [nucleotide binding]; other site 246194004941 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 246194004942 NusA N-terminal domain; Region: NusA_N; pfam08529 246194004943 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 246194004944 RNA binding site [nucleotide binding]; other site 246194004945 homodimer interface [polypeptide binding]; other site 246194004946 NusA-like KH domain; Region: KH_5; pfam13184 246194004947 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246194004948 G-X-X-G motif; other site 246194004949 ribosome maturation protein RimP; Reviewed; Region: PRK00092 246194004950 Sm and related proteins; Region: Sm_like; cl00259 246194004951 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 246194004952 putative oligomer interface [polypeptide binding]; other site 246194004953 putative RNA binding site [nucleotide binding]; other site 246194004954 DNA polymerase III PolC; Validated; Region: polC; PRK00448 246194004955 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 246194004956 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 246194004957 generic binding surface II; other site 246194004958 generic binding surface I; other site 246194004959 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246194004960 active site 246194004961 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246194004962 active site 246194004963 catalytic site [active] 246194004964 substrate binding site [chemical binding]; other site 246194004965 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 246194004966 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 246194004967 MgtC family; Region: MgtC; pfam02308 246194004968 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246194004969 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246194004970 Ligand binding site; other site 246194004971 Putative Catalytic site; other site 246194004972 DXD motif; other site 246194004973 prolyl-tRNA synthetase; Provisional; Region: PRK09194 246194004974 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 246194004975 dimer interface [polypeptide binding]; other site 246194004976 motif 1; other site 246194004977 active site 246194004978 motif 2; other site 246194004979 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 246194004980 putative deacylase active site [active] 246194004981 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246194004982 active site 246194004983 motif 3; other site 246194004984 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 246194004985 anticodon binding site; other site 246194004986 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 246194004987 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 246194004988 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 246194004989 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 246194004990 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 246194004991 active site 246194004992 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246194004993 protein binding site [polypeptide binding]; other site 246194004994 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246194004995 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246194004996 putative substrate binding region [chemical binding]; other site 246194004997 putative substrate binding region [chemical binding]; other site 246194004998 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 246194004999 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 246194005000 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 246194005001 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 246194005002 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 246194005003 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246194005004 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 246194005005 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 246194005006 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 246194005007 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 246194005008 catalytic residue [active] 246194005009 putative FPP diphosphate binding site; other site 246194005010 putative FPP binding hydrophobic cleft; other site 246194005011 dimer interface [polypeptide binding]; other site 246194005012 putative IPP diphosphate binding site; other site 246194005013 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194005014 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 246194005015 ribosome recycling factor; Reviewed; Region: frr; PRK00083 246194005016 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 246194005017 hinge region; other site 246194005018 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 246194005019 putative nucleotide binding site [chemical binding]; other site 246194005020 uridine monophosphate binding site [chemical binding]; other site 246194005021 homohexameric interface [polypeptide binding]; other site 246194005022 elongation factor Ts; Reviewed; Region: tsf; PRK12332 246194005023 UBA/TS-N domain; Region: UBA; pfam00627 246194005024 Elongation factor TS; Region: EF_TS; pfam00889 246194005025 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 246194005026 rRNA interaction site [nucleotide binding]; other site 246194005027 S8 interaction site; other site 246194005028 putative laminin-1 binding site; other site 246194005029 transcriptional repressor CodY; Validated; Region: PRK04158 246194005030 CodY GAF-like domain; Region: CodY; pfam06018 246194005031 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 246194005032 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 246194005033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194005034 Walker A motif; other site 246194005035 ATP binding site [chemical binding]; other site 246194005036 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 246194005037 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246194005038 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 246194005039 active site 246194005040 HslU subunit interaction site [polypeptide binding]; other site 246194005041 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 246194005042 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 246194005043 active site 246194005044 Int/Topo IB signature motif; other site 246194005045 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 246194005046 Glucose inhibited division protein A; Region: GIDA; pfam01134 246194005047 DNA topoisomerase I; Validated; Region: PRK05582 246194005048 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 246194005049 active site 246194005050 interdomain interaction site; other site 246194005051 putative metal-binding site [ion binding]; other site 246194005052 nucleotide binding site [chemical binding]; other site 246194005053 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 246194005054 domain I; other site 246194005055 DNA binding groove [nucleotide binding] 246194005056 phosphate binding site [ion binding]; other site 246194005057 domain II; other site 246194005058 domain III; other site 246194005059 nucleotide binding site [chemical binding]; other site 246194005060 catalytic site [active] 246194005061 domain IV; other site 246194005062 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 246194005063 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 246194005064 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 246194005065 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 246194005066 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 246194005067 DNA protecting protein DprA; Region: dprA; TIGR00732 246194005068 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 246194005069 nucleotide binding site [chemical binding]; other site 246194005070 Nitroreductase family; Region: Nitroreductase; pfam00881 246194005071 FMN binding site [chemical binding]; other site 246194005072 dimer interface [polypeptide binding]; other site 246194005073 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246194005074 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246194005075 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 246194005076 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 246194005077 G1 box; other site 246194005078 putative GEF interaction site [polypeptide binding]; other site 246194005079 GTP/Mg2+ binding site [chemical binding]; other site 246194005080 Switch I region; other site 246194005081 G2 box; other site 246194005082 G3 box; other site 246194005083 Switch II region; other site 246194005084 G4 box; other site 246194005085 G5 box; other site 246194005086 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 246194005087 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 246194005088 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 246194005089 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 246194005090 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 246194005091 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 246194005092 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 246194005093 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246194005094 catalytic residue [active] 246194005095 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 246194005096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194005097 FeS/SAM binding site; other site 246194005098 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 246194005099 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246194005100 substrate binding site [chemical binding]; other site 246194005101 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 246194005102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194005103 FeS/SAM binding site; other site 246194005104 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 246194005105 UbiA prenyltransferase family; Region: UbiA; pfam01040 246194005106 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 246194005107 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 246194005108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194005109 S-adenosylmethionine binding site [chemical binding]; other site 246194005110 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 246194005111 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 246194005112 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 246194005113 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246194005114 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246194005115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194005116 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 246194005117 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246194005118 putative DNA binding site [nucleotide binding]; other site 246194005119 AAA domain; Region: AAA_30; pfam13604 246194005120 Family description; Region: UvrD_C_2; pfam13538 246194005121 hydroxylamine reductase; Provisional; Region: PRK12310 246194005122 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 246194005123 cubane metal cluster [ion binding]; other site 246194005124 hybrid metal cluster; other site 246194005125 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 246194005126 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 246194005127 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 246194005128 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 246194005129 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 246194005130 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 246194005131 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 246194005132 ACS interaction site; other site 246194005133 CODH interaction site; other site 246194005134 cubane metal cluster (B-cluster) [ion binding]; other site 246194005135 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 246194005136 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 246194005137 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194005138 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 246194005139 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 246194005140 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 246194005141 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 246194005142 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 246194005143 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 246194005144 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194005145 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 246194005146 NADH dehydrogenase; Region: NADHdh; cl00469 246194005147 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246194005148 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 246194005149 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246194005150 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 246194005151 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246194005152 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246194005153 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 246194005154 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 246194005155 P-loop; other site 246194005156 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194005157 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246194005158 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246194005159 ligand binding site [chemical binding]; other site 246194005160 flexible hinge region; other site 246194005161 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246194005162 putative switch regulator; other site 246194005163 non-specific DNA interactions [nucleotide binding]; other site 246194005164 DNA binding site [nucleotide binding] 246194005165 sequence specific DNA binding site [nucleotide binding]; other site 246194005166 putative cAMP binding site [chemical binding]; other site 246194005167 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 246194005168 Cysteine-rich domain; Region: CCG; pfam02754 246194005169 Cysteine-rich domain; Region: CCG; pfam02754 246194005170 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 246194005171 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 246194005172 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 246194005173 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 246194005174 glycerol kinase; Provisional; Region: glpK; PRK00047 246194005175 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 246194005176 N- and C-terminal domain interface [polypeptide binding]; other site 246194005177 active site 246194005178 MgATP binding site [chemical binding]; other site 246194005179 catalytic site [active] 246194005180 metal binding site [ion binding]; metal-binding site 246194005181 glycerol binding site [chemical binding]; other site 246194005182 homotetramer interface [polypeptide binding]; other site 246194005183 homodimer interface [polypeptide binding]; other site 246194005184 FBP binding site [chemical binding]; other site 246194005185 protein IIAGlc interface [polypeptide binding]; other site 246194005186 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 246194005187 amphipathic channel; other site 246194005188 Asn-Pro-Ala signature motifs; other site 246194005189 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 246194005190 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 246194005191 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246194005192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194005193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194005194 DNA binding residues [nucleotide binding] 246194005195 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246194005196 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 246194005197 NodB motif; other site 246194005198 active site 246194005199 metal binding site [ion binding]; metal-binding site 246194005200 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246194005201 active site 246194005202 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246194005203 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246194005204 putative active site [active] 246194005205 putative metal binding site [ion binding]; other site 246194005206 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 246194005207 putative [Fe4-S4] binding site [ion binding]; other site 246194005208 putative molybdopterin cofactor binding site [chemical binding]; other site 246194005209 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 246194005210 putative molybdopterin cofactor binding site; other site 246194005211 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 246194005212 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 246194005213 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246194005214 4Fe-4S binding domain; Region: Fer4_6; pfam12837 246194005215 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246194005216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194005217 active site 246194005218 phosphorylation site [posttranslational modification] 246194005219 intermolecular recognition site; other site 246194005220 dimerization interface [polypeptide binding]; other site 246194005221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194005222 Walker A motif; other site 246194005223 ATP binding site [chemical binding]; other site 246194005224 Walker B motif; other site 246194005225 arginine finger; other site 246194005226 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194005227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194005228 dimerization interface [polypeptide binding]; other site 246194005229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194005230 phosphorylation site [posttranslational modification] 246194005231 dimer interface [polypeptide binding]; other site 246194005232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194005233 ATP binding site [chemical binding]; other site 246194005234 Mg2+ binding site [ion binding]; other site 246194005235 G-X-G motif; other site 246194005236 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 246194005237 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 246194005238 zinc binding site [ion binding]; other site 246194005239 putative ligand binding site [chemical binding]; other site 246194005240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194005241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194005242 metal binding site [ion binding]; metal-binding site 246194005243 active site 246194005244 I-site; other site 246194005245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194005246 sequence-specific DNA binding site [nucleotide binding]; other site 246194005247 salt bridge; other site 246194005248 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 246194005249 HlyD family secretion protein; Region: HlyD_3; pfam13437 246194005250 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 246194005251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194005252 putative substrate translocation pore; other site 246194005253 Predicted transcriptional regulators [Transcription]; Region: COG1378 246194005254 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 246194005255 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246194005256 putative active site [active] 246194005257 catalytic site [active] 246194005258 EamA-like transporter family; Region: EamA; pfam00892 246194005259 EamA-like transporter family; Region: EamA; pfam00892 246194005260 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246194005261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194005262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194005263 DNA binding residues [nucleotide binding] 246194005264 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 246194005265 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 246194005266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246194005267 Coenzyme A binding pocket [chemical binding]; other site 246194005268 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 246194005269 elongation factor P; Validated; Region: PRK00529 246194005270 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 246194005271 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 246194005272 RNA binding site [nucleotide binding]; other site 246194005273 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 246194005274 RNA binding site [nucleotide binding]; other site 246194005275 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246194005276 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246194005277 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 246194005278 active site 246194005279 Dehydroquinase class II; Region: DHquinase_II; pfam01220 246194005280 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 246194005281 active site 246194005282 trimer interface [polypeptide binding]; other site 246194005283 dimer interface [polypeptide binding]; other site 246194005284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194005285 PAS domain; Region: PAS_9; pfam13426 246194005286 putative active site [active] 246194005287 heme pocket [chemical binding]; other site 246194005288 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194005289 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194005290 metal binding site [ion binding]; metal-binding site 246194005291 active site 246194005292 I-site; other site 246194005293 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194005294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194005295 Zn2+ binding site [ion binding]; other site 246194005296 Mg2+ binding site [ion binding]; other site 246194005297 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 246194005298 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 246194005299 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 246194005300 homodimer interface [polypeptide binding]; other site 246194005301 NADP binding site [chemical binding]; other site 246194005302 substrate binding site [chemical binding]; other site 246194005303 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 246194005304 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194005305 active site 246194005306 NTP binding site [chemical binding]; other site 246194005307 metal binding triad [ion binding]; metal-binding site 246194005308 antibiotic binding site [chemical binding]; other site 246194005309 VPS10 domain; Region: VPS10; smart00602 246194005310 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194005311 active site 246194005312 NTP binding site [chemical binding]; other site 246194005313 metal binding triad [ion binding]; metal-binding site 246194005314 antibiotic binding site [chemical binding]; other site 246194005315 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 246194005316 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246194005317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 246194005318 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 246194005319 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 246194005320 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 246194005321 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 246194005322 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246194005323 homodimer interface [polypeptide binding]; other site 246194005324 substrate-cofactor binding pocket; other site 246194005325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194005326 catalytic residue [active] 246194005327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194005328 Zn2+ binding site [ion binding]; other site 246194005329 Mg2+ binding site [ion binding]; other site 246194005330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194005331 Zn2+ binding site [ion binding]; other site 246194005332 Mg2+ binding site [ion binding]; other site 246194005333 PAS domain S-box; Region: sensory_box; TIGR00229 246194005334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194005335 putative active site [active] 246194005336 heme pocket [chemical binding]; other site 246194005337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194005338 PAS fold; Region: PAS_3; pfam08447 246194005339 putative active site [active] 246194005340 heme pocket [chemical binding]; other site 246194005341 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194005342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194005343 metal binding site [ion binding]; metal-binding site 246194005344 active site 246194005345 I-site; other site 246194005346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 246194005347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246194005348 non-specific DNA binding site [nucleotide binding]; other site 246194005349 salt bridge; other site 246194005350 sequence-specific DNA binding site [nucleotide binding]; other site 246194005351 aspartate kinase; Reviewed; Region: PRK06635 246194005352 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 246194005353 putative nucleotide binding site [chemical binding]; other site 246194005354 putative catalytic residues [active] 246194005355 putative Mg ion binding site [ion binding]; other site 246194005356 putative aspartate binding site [chemical binding]; other site 246194005357 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 246194005358 putative allosteric regulatory site; other site 246194005359 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 246194005360 homoserine kinase; Provisional; Region: PRK01212 246194005361 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246194005362 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 246194005363 threonine synthase; Reviewed; Region: PRK06721 246194005364 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 246194005365 homodimer interface [polypeptide binding]; other site 246194005366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194005367 catalytic residue [active] 246194005368 homoserine dehydrogenase; Provisional; Region: PRK06349 246194005369 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 246194005370 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 246194005371 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 246194005372 hypothetical protein; Provisional; Region: PRK04435 246194005373 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 246194005374 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 246194005375 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 246194005376 putative active site [active] 246194005377 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 246194005378 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 246194005379 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 246194005380 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 246194005381 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 246194005382 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246194005383 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 246194005384 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 246194005385 GTP-binding protein Der; Reviewed; Region: PRK00093 246194005386 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 246194005387 G1 box; other site 246194005388 GTP/Mg2+ binding site [chemical binding]; other site 246194005389 Switch I region; other site 246194005390 G2 box; other site 246194005391 Switch II region; other site 246194005392 G3 box; other site 246194005393 G4 box; other site 246194005394 G5 box; other site 246194005395 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 246194005396 G1 box; other site 246194005397 GTP/Mg2+ binding site [chemical binding]; other site 246194005398 Switch I region; other site 246194005399 G2 box; other site 246194005400 G3 box; other site 246194005401 Switch II region; other site 246194005402 G4 box; other site 246194005403 G5 box; other site 246194005404 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246194005405 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 246194005406 Protein of unknown function (DUF512); Region: DUF512; pfam04459 246194005407 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 246194005408 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 246194005409 stage II sporulation protein P; Region: spore_II_P; TIGR02867 246194005410 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 246194005411 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 246194005412 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 246194005413 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 246194005414 RNA binding site [nucleotide binding]; other site 246194005415 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 246194005416 RNA binding site [nucleotide binding]; other site 246194005417 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246194005418 RNA binding site [nucleotide binding]; other site 246194005419 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 246194005420 RNA binding site [nucleotide binding]; other site 246194005421 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246194005422 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246194005423 putative acyl-acceptor binding pocket; other site 246194005424 cytidylate kinase; Provisional; Region: cmk; PRK00023 246194005425 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 246194005426 CMP-binding site; other site 246194005427 The sites determining sugar specificity; other site 246194005428 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 246194005429 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 246194005430 hinge; other site 246194005431 active site 246194005432 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 246194005433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246194005434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194005435 homodimer interface [polypeptide binding]; other site 246194005436 catalytic residue [active] 246194005437 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 246194005438 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 246194005439 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 246194005440 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 246194005441 glutamine binding [chemical binding]; other site 246194005442 catalytic triad [active] 246194005443 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 246194005444 homotrimer interaction site [polypeptide binding]; other site 246194005445 active site 246194005446 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 246194005447 RNA binding site [nucleotide binding]; other site 246194005448 hexamer interface [polypeptide binding]; other site 246194005449 Histidine-zinc binding site [chemical binding]; other site 246194005450 flavoprotein, HI0933 family; Region: TIGR00275 246194005451 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246194005452 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194005453 RNA binding surface [nucleotide binding]; other site 246194005454 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 246194005455 active site 246194005456 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246194005457 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 246194005458 active site 246194005459 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 246194005460 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 246194005461 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 246194005462 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 246194005463 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 246194005464 ScpA/B protein; Region: ScpA_ScpB; cl00598 246194005465 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 246194005466 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 246194005467 active site 246194005468 HIGH motif; other site 246194005469 dimer interface [polypeptide binding]; other site 246194005470 KMSKS motif; other site 246194005471 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 246194005472 Peptidase family M50; Region: Peptidase_M50; pfam02163 246194005473 active site 246194005474 putative substrate binding region [chemical binding]; other site 246194005475 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 246194005476 DHH family; Region: DHH; pfam01368 246194005477 FOG: CBS domain [General function prediction only]; Region: COG0517 246194005478 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 246194005479 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 246194005480 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 246194005481 active site 246194005482 NTP binding site [chemical binding]; other site 246194005483 metal binding triad [ion binding]; metal-binding site 246194005484 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 246194005485 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 246194005486 Spore germination protein; Region: Spore_permease; cl17796 246194005487 diaminopimelate decarboxylase; Region: lysA; TIGR01048 246194005488 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 246194005489 active site 246194005490 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246194005491 substrate binding site [chemical binding]; other site 246194005492 catalytic residues [active] 246194005493 dimer interface [polypeptide binding]; other site 246194005494 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 246194005495 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 246194005496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 246194005497 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 246194005498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 246194005499 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 246194005500 stage V sporulation protein AD; Provisional; Region: PRK12404 246194005501 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 246194005502 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 246194005503 Dodecin; Region: Dodecin; pfam07311 246194005504 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 246194005505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194005506 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246194005507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194005508 DNA binding residues [nucleotide binding] 246194005509 anti-sigma F factor; Provisional; Region: PRK03660 246194005510 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246194005511 ATP binding site [chemical binding]; other site 246194005512 Mg2+ binding site [ion binding]; other site 246194005513 G-X-G motif; other site 246194005514 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246194005515 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246194005516 anti sigma factor interaction site; other site 246194005517 regulatory phosphorylation site [posttranslational modification]; other site 246194005518 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246194005519 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 246194005520 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 246194005521 phosphopentomutase; Provisional; Region: PRK05362 246194005522 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 246194005523 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 246194005524 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 246194005525 active site 246194005526 Int/Topo IB signature motif; other site 246194005527 Integral membrane protein DUF95; Region: DUF95; cl00572 246194005528 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 246194005529 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194005530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194005531 Zn2+ binding site [ion binding]; other site 246194005532 Mg2+ binding site [ion binding]; other site 246194005533 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 246194005534 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 246194005535 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 246194005536 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 246194005537 TPP-binding site [chemical binding]; other site 246194005538 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 246194005539 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 246194005540 dimer interface [polypeptide binding]; other site 246194005541 PYR/PP interface [polypeptide binding]; other site 246194005542 TPP binding site [chemical binding]; other site 246194005543 substrate binding site [chemical binding]; other site 246194005544 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246194005545 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194005546 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 246194005547 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 246194005548 Mg++ binding site [ion binding]; other site 246194005549 putative catalytic motif [active] 246194005550 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246194005551 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246194005552 Ligand binding site; other site 246194005553 Putative Catalytic site; other site 246194005554 DXD motif; other site 246194005555 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 246194005556 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 246194005557 Thiamine pyrophosphokinase; Region: TPK; cl08415 246194005558 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 246194005559 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 246194005560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194005561 active site 246194005562 phosphorylation site [posttranslational modification] 246194005563 intermolecular recognition site; other site 246194005564 dimerization interface [polypeptide binding]; other site 246194005565 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 246194005566 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 246194005567 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246194005568 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 246194005569 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 246194005570 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 246194005571 Walker A/P-loop; other site 246194005572 ATP binding site [chemical binding]; other site 246194005573 Q-loop/lid; other site 246194005574 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 246194005575 Q-loop/lid; other site 246194005576 ABC transporter signature motif; other site 246194005577 Walker B; other site 246194005578 D-loop; other site 246194005579 H-loop/switch region; other site 246194005580 Arginine repressor [Transcription]; Region: ArgR; COG1438 246194005581 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 246194005582 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 246194005583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194005584 S-adenosylmethionine binding site [chemical binding]; other site 246194005585 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 246194005586 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 246194005587 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 246194005588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194005589 RNA binding surface [nucleotide binding]; other site 246194005590 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 246194005591 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 246194005592 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 246194005593 TPP-binding site; other site 246194005594 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246194005595 PYR/PP interface [polypeptide binding]; other site 246194005596 dimer interface [polypeptide binding]; other site 246194005597 TPP binding site [chemical binding]; other site 246194005598 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246194005599 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246194005600 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246194005601 substrate binding pocket [chemical binding]; other site 246194005602 chain length determination region; other site 246194005603 substrate-Mg2+ binding site; other site 246194005604 catalytic residues [active] 246194005605 aspartate-rich region 1; other site 246194005606 active site lid residues [active] 246194005607 aspartate-rich region 2; other site 246194005608 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 246194005609 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 246194005610 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 246194005611 generic binding surface II; other site 246194005612 generic binding surface I; other site 246194005613 putative oxidoreductase; Provisional; Region: PRK12831 246194005614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246194005615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194005616 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 246194005617 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 246194005618 FAD binding pocket [chemical binding]; other site 246194005619 FAD binding motif [chemical binding]; other site 246194005620 phosphate binding motif [ion binding]; other site 246194005621 beta-alpha-beta structure motif; other site 246194005622 NAD binding pocket [chemical binding]; other site 246194005623 Iron coordination center [ion binding]; other site 246194005624 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 246194005625 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 246194005626 putative RNA binding site [nucleotide binding]; other site 246194005627 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 246194005628 Asp23 family; Region: Asp23; pfam03780 246194005629 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 246194005630 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246194005631 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246194005632 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246194005633 pyruvate carboxylase subunit B; Validated; Region: PRK09282 246194005634 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 246194005635 active site 246194005636 catalytic residues [active] 246194005637 metal binding site [ion binding]; metal-binding site 246194005638 homodimer binding site [polypeptide binding]; other site 246194005639 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246194005640 carboxyltransferase (CT) interaction site; other site 246194005641 biotinylation site [posttranslational modification]; other site 246194005642 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 246194005643 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 246194005644 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 246194005645 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 246194005646 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 246194005647 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 246194005648 stage III sporulation protein AB; Region: spore_III_AB; TIGR02833 246194005649 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 246194005650 Haemolysin XhlA; Region: XhlA; pfam10779 246194005651 Haemolysin XhlA; Region: XhlA; pfam10779 246194005652 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 246194005653 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246194005654 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246194005655 glutaminase active site [active] 246194005656 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246194005657 dimer interface [polypeptide binding]; other site 246194005658 active site 246194005659 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246194005660 dimer interface [polypeptide binding]; other site 246194005661 active site 246194005662 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 246194005663 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 246194005664 active site 246194005665 substrate binding site [chemical binding]; other site 246194005666 metal binding site [ion binding]; metal-binding site 246194005667 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 246194005668 YbbR-like protein; Region: YbbR; pfam07949 246194005669 Uncharacterized conserved protein [Function unknown]; Region: COG1624 246194005670 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 246194005671 uracil transporter; Provisional; Region: PRK10720 246194005672 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246194005673 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 246194005674 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246194005675 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246194005676 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 246194005677 transmembrane helices; other site 246194005678 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246194005679 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 246194005680 transmembrane helices; other site 246194005681 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246194005682 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246194005683 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246194005684 substrate binding pocket [chemical binding]; other site 246194005685 membrane-bound complex binding site; other site 246194005686 hinge residues; other site 246194005687 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246194005688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194005689 dimer interface [polypeptide binding]; other site 246194005690 phosphorylation site [posttranslational modification] 246194005691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194005692 ATP binding site [chemical binding]; other site 246194005693 Mg2+ binding site [ion binding]; other site 246194005694 G-X-G motif; other site 246194005695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246194005696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246194005697 active site 246194005698 GAF domain; Region: GAF_3; pfam13492 246194005699 GAF domain; Region: GAF_2; pfam13185 246194005700 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194005701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194005702 metal binding site [ion binding]; metal-binding site 246194005703 active site 246194005704 I-site; other site 246194005705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194005706 Zn2+ binding site [ion binding]; other site 246194005707 Mg2+ binding site [ion binding]; other site 246194005708 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 246194005709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194005710 S-adenosylmethionine binding site [chemical binding]; other site 246194005711 Uncharacterized conserved protein [Function unknown]; Region: COG3270 246194005712 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 246194005713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246194005714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246194005715 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246194005716 FAD binding domain; Region: FAD_binding_4; pfam01565 246194005717 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194005718 Cysteine-rich domain; Region: CCG; pfam02754 246194005719 Cysteine-rich domain; Region: CCG; pfam02754 246194005720 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 246194005721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194005722 putative substrate translocation pore; other site 246194005723 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 246194005724 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 246194005725 Na binding site [ion binding]; other site 246194005726 Protein of unknown function, DUF485; Region: DUF485; pfam04341 246194005727 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 246194005728 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246194005729 ligand binding site [chemical binding]; other site 246194005730 flexible hinge region; other site 246194005731 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 246194005732 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 246194005733 metal binding triad; other site 246194005734 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246194005735 active site 246194005736 catalytic site [active] 246194005737 substrate binding site [chemical binding]; other site 246194005738 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246194005739 FAD binding domain; Region: FAD_binding_4; pfam01565 246194005740 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194005741 Cysteine-rich domain; Region: CCG; pfam02754 246194005742 Cysteine-rich domain; Region: CCG; pfam02754 246194005743 DivIVA protein; Region: DivIVA; pfam05103 246194005744 DivIVA domain; Region: DivI1A_domain; TIGR03544 246194005745 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 246194005746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194005747 RNA binding surface [nucleotide binding]; other site 246194005748 YGGT family; Region: YGGT; pfam02325 246194005749 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 246194005750 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 246194005751 Protein of unknown function (DUF552); Region: DUF552; pfam04472 246194005752 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 246194005753 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246194005754 catalytic residue [active] 246194005755 HlyD family secretion protein; Region: HlyD_2; pfam12700 246194005756 putative membrane fusion protein; Region: TIGR02828 246194005757 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 246194005758 PhoU domain; Region: PhoU; pfam01895 246194005759 PhoU domain; Region: PhoU; pfam01895 246194005760 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246194005761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194005762 putative active site [active] 246194005763 heme pocket [chemical binding]; other site 246194005764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194005765 dimer interface [polypeptide binding]; other site 246194005766 phosphorylation site [posttranslational modification] 246194005767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194005768 ATP binding site [chemical binding]; other site 246194005769 Mg2+ binding site [ion binding]; other site 246194005770 G-X-G motif; other site 246194005771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246194005772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194005773 active site 246194005774 phosphorylation site [posttranslational modification] 246194005775 intermolecular recognition site; other site 246194005776 dimerization interface [polypeptide binding]; other site 246194005777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246194005778 DNA binding site [nucleotide binding] 246194005779 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 246194005780 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 246194005781 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 246194005782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194005783 Beta-Casp domain; Region: Beta-Casp; smart01027 246194005784 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 246194005785 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 246194005786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194005787 FeS/SAM binding site; other site 246194005788 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 246194005789 ATP cone domain; Region: ATP-cone; pfam03477 246194005790 Class III ribonucleotide reductase; Region: RNR_III; cd01675 246194005791 effector binding site; other site 246194005792 active site 246194005793 Zn binding site [ion binding]; other site 246194005794 glycine loop; other site 246194005795 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 246194005796 ATP cone domain; Region: ATP-cone; pfam03477 246194005797 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 246194005798 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 246194005799 sporulation sigma factor SigG; Reviewed; Region: PRK08215 246194005800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194005801 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246194005802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194005803 DNA binding residues [nucleotide binding] 246194005804 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 246194005805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194005806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246194005807 DNA binding residues [nucleotide binding] 246194005808 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 246194005809 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 246194005810 selenophosphate synthetase; Provisional; Region: PRK00943 246194005811 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 246194005812 dimerization interface [polypeptide binding]; other site 246194005813 putative ATP binding site [chemical binding]; other site 246194005814 cell division protein FtsZ; Validated; Region: PRK09330 246194005815 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 246194005816 nucleotide binding site [chemical binding]; other site 246194005817 SulA interaction site; other site 246194005818 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 246194005819 Cell division protein FtsA; Region: FtsA; smart00842 246194005820 Cell division protein FtsA; Region: FtsA; pfam14450 246194005821 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 246194005822 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 246194005823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 246194005824 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 246194005825 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 246194005826 Cell division protein FtsQ; Region: FtsQ; pfam03799 246194005827 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 246194005828 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 246194005829 hinge; other site 246194005830 active site 246194005831 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 246194005832 FAD binding domain; Region: FAD_binding_4; pfam01565 246194005833 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 246194005834 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 246194005835 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246194005836 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246194005837 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246194005838 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 246194005839 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 246194005840 active site 246194005841 homodimer interface [polypeptide binding]; other site 246194005842 cell division protein FtsW; Region: ftsW; TIGR02614 246194005843 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 246194005844 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 246194005845 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246194005846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246194005847 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 246194005848 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 246194005849 Mg++ binding site [ion binding]; other site 246194005850 putative catalytic motif [active] 246194005851 putative substrate binding site [chemical binding]; other site 246194005852 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 246194005853 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246194005854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246194005855 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246194005856 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 246194005857 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246194005858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246194005859 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246194005860 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 246194005861 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 246194005862 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246194005863 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 246194005864 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 246194005865 Septum formation initiator; Region: DivIC; cl17659 246194005866 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 246194005867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194005868 S-adenosylmethionine binding site [chemical binding]; other site 246194005869 cell division protein MraZ; Reviewed; Region: PRK00326 246194005870 MraZ protein; Region: MraZ; pfam02381 246194005871 MraZ protein; Region: MraZ; pfam02381 246194005872 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 246194005873 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 246194005874 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 246194005875 4Fe-4S binding domain; Region: Fer4; cl02805 246194005876 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194005877 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 246194005878 molybdopterin cofactor binding site; other site 246194005879 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194005880 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246194005881 The MopB_CT_4 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_4; cd02785 246194005882 putative molybdopterin cofactor binding site; other site 246194005883 HPP family; Region: HPP; pfam04982 246194005884 histidinol-phosphatase; Provisional; Region: PRK07328 246194005885 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 246194005886 active site 246194005887 dimer interface [polypeptide binding]; other site 246194005888 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 246194005889 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 246194005890 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246194005891 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 246194005892 nucleophile elbow; other site 246194005893 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 246194005894 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246194005895 Uncharacterized conserved protein [Function unknown]; Region: COG1434 246194005896 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246194005897 putative active site [active] 246194005898 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 246194005899 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 246194005900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194005901 putative active site [active] 246194005902 heme pocket [chemical binding]; other site 246194005903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194005904 Walker A motif; other site 246194005905 ATP binding site [chemical binding]; other site 246194005906 Walker B motif; other site 246194005907 arginine finger; other site 246194005908 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246194005909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246194005910 FtsX-like permease family; Region: FtsX; pfam02687 246194005911 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 246194005912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246194005913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246194005914 Walker A/P-loop; other site 246194005915 ATP binding site [chemical binding]; other site 246194005916 Q-loop/lid; other site 246194005917 ABC transporter signature motif; other site 246194005918 Walker B; other site 246194005919 D-loop; other site 246194005920 H-loop/switch region; other site 246194005921 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246194005922 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 246194005923 Penicillinase repressor; Region: Pencillinase_R; pfam03965 246194005924 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246194005925 metal binding site 2 [ion binding]; metal-binding site 246194005926 putative DNA binding helix; other site 246194005927 metal binding site 1 [ion binding]; metal-binding site 246194005928 dimer interface [polypeptide binding]; other site 246194005929 structural Zn2+ binding site [ion binding]; other site 246194005930 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 246194005931 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246194005932 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 246194005933 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 246194005934 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 246194005935 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 246194005936 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 246194005937 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 246194005938 Dynamin family; Region: Dynamin_N; pfam00350 246194005939 G1 box; other site 246194005940 GTP/Mg2+ binding site [chemical binding]; other site 246194005941 G2 box; other site 246194005942 Switch I region; other site 246194005943 G3 box; other site 246194005944 Switch II region; other site 246194005945 G4 box; other site 246194005946 G5 box; other site 246194005947 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246194005948 Ligand Binding Site [chemical binding]; other site 246194005949 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 246194005950 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246194005951 FeoA domain; Region: FeoA; pfam04023 246194005952 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 246194005953 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 246194005954 Walker A/P-loop; other site 246194005955 ATP binding site [chemical binding]; other site 246194005956 Q-loop/lid; other site 246194005957 ABC transporter signature motif; other site 246194005958 Walker B; other site 246194005959 D-loop; other site 246194005960 H-loop/switch region; other site 246194005961 Domain of unknown function DUF87; Region: DUF87; pfam01935 246194005962 HerA helicase [Replication, recombination, and repair]; Region: COG0433 246194005963 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 246194005964 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 246194005965 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 246194005966 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 246194005967 Predicted transcriptional regulator [Transcription]; Region: COG2378 246194005968 WYL domain; Region: WYL; pfam13280 246194005969 HTH domain; Region: HTH_11; pfam08279 246194005970 WYL domain; Region: WYL; pfam13280 246194005971 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 246194005972 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 246194005973 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 246194005974 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 246194005975 Protein of unknown function (DUF541); Region: SIMPL; cl01077 246194005976 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 246194005977 oligomer interface [polypeptide binding]; other site 246194005978 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 246194005979 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 246194005980 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 246194005981 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 246194005982 Protein of unknown function (DUF310); Region: DUF310; pfam03750 246194005983 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 246194005984 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 246194005985 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 246194005986 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 246194005987 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 246194005988 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 246194005989 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 246194005990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246194005991 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 246194005992 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-B; cd09692 246194005993 Family of unknown function (DUF694); Region: DUF694; pfam05107 246194005994 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 246194005995 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 246194005996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194005997 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246194005998 Walker A motif; other site 246194005999 ATP binding site [chemical binding]; other site 246194006000 Walker B motif; other site 246194006001 arginine finger; other site 246194006002 Staphylococcal nuclease homologues; Region: SNc; smart00318 246194006003 Catalytic site; other site 246194006004 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 246194006005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 246194006006 Transposase; Region: DDE_Tnp_ISL3; pfam01610 246194006007 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 246194006008 TPR repeat; Region: TPR_11; pfam13414 246194006009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246194006010 binding surface 246194006011 TPR motif; other site 246194006012 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246194006013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246194006014 TPR motif; other site 246194006015 binding surface 246194006016 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 246194006017 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194006018 active site 246194006019 NTP binding site [chemical binding]; other site 246194006020 metal binding triad [ion binding]; metal-binding site 246194006021 antibiotic binding site [chemical binding]; other site 246194006022 FtsX-like permease family; Region: FtsX; pfam02687 246194006023 FtsX-like permease family; Region: FtsX; pfam02687 246194006024 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246194006025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246194006026 Walker A/P-loop; other site 246194006027 ATP binding site [chemical binding]; other site 246194006028 Q-loop/lid; other site 246194006029 ABC transporter signature motif; other site 246194006030 Walker B; other site 246194006031 D-loop; other site 246194006032 H-loop/switch region; other site 246194006033 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 246194006034 Part of AAA domain; Region: AAA_19; pfam13245 246194006035 Family description; Region: UvrD_C_2; pfam13538 246194006036 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246194006037 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 246194006038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246194006039 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246194006040 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 246194006041 active site 246194006042 metal binding site [ion binding]; metal-binding site 246194006043 homotetramer interface [polypeptide binding]; other site 246194006044 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246194006045 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246194006046 Walker A/P-loop; other site 246194006047 ATP binding site [chemical binding]; other site 246194006048 Q-loop/lid; other site 246194006049 ABC transporter signature motif; other site 246194006050 Walker B; other site 246194006051 D-loop; other site 246194006052 H-loop/switch region; other site 246194006053 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246194006054 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246194006055 Walker A/P-loop; other site 246194006056 ATP binding site [chemical binding]; other site 246194006057 Q-loop/lid; other site 246194006058 ABC transporter signature motif; other site 246194006059 Walker B; other site 246194006060 D-loop; other site 246194006061 H-loop/switch region; other site 246194006062 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 246194006063 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246194006064 ABC-ATPase subunit interface; other site 246194006065 dimer interface [polypeptide binding]; other site 246194006066 putative PBP binding regions; other site 246194006067 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 246194006068 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 246194006069 putative metal binding site [ion binding]; other site 246194006070 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 246194006071 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 246194006072 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 246194006073 PAS domain S-box; Region: sensory_box; TIGR00229 246194006074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246194006075 putative active site [active] 246194006076 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194006077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194006078 metal binding site [ion binding]; metal-binding site 246194006079 active site 246194006080 I-site; other site 246194006081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006082 Zn2+ binding site [ion binding]; other site 246194006083 Mg2+ binding site [ion binding]; other site 246194006084 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 246194006085 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 246194006086 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 246194006087 Ligand Binding Site [chemical binding]; other site 246194006088 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 246194006089 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 246194006090 trimerization site [polypeptide binding]; other site 246194006091 active site 246194006092 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 246194006093 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 246194006094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246194006095 catalytic residue [active] 246194006096 Predicted transcriptional regulator [Transcription]; Region: COG1959 246194006097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194006098 dimerization interface [polypeptide binding]; other site 246194006099 putative Zn2+ binding site [ion binding]; other site 246194006100 putative DNA binding site [nucleotide binding]; other site 246194006101 recombination factor protein RarA; Reviewed; Region: PRK13342 246194006102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194006103 Walker A motif; other site 246194006104 ATP binding site [chemical binding]; other site 246194006105 Walker B motif; other site 246194006106 arginine finger; other site 246194006107 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 246194006108 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246194006109 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246194006110 catalytic residues [active] 246194006111 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 246194006112 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 246194006113 putative ATP binding site [chemical binding]; other site 246194006114 putative substrate interface [chemical binding]; other site 246194006115 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 246194006116 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 246194006117 dimer interface [polypeptide binding]; other site 246194006118 anticodon binding site; other site 246194006119 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 246194006120 homodimer interface [polypeptide binding]; other site 246194006121 motif 1; other site 246194006122 active site 246194006123 motif 2; other site 246194006124 GAD domain; Region: GAD; pfam02938 246194006125 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 246194006126 motif 3; other site 246194006127 histidyl-tRNA synthetase; Region: hisS; TIGR00442 246194006128 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 246194006129 dimer interface [polypeptide binding]; other site 246194006130 motif 1; other site 246194006131 active site 246194006132 motif 2; other site 246194006133 motif 3; other site 246194006134 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 246194006135 anticodon binding site; other site 246194006136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246194006137 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246194006138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246194006139 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 246194006140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194006141 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246194006142 FeS/SAM binding site; other site 246194006143 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 246194006144 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 246194006145 DpnII restriction endonuclease; Region: DpnII; pfam04556 246194006146 DNA methylase; Region: N6_N4_Mtase; pfam01555 246194006147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194006148 S-adenosylmethionine binding site [chemical binding]; other site 246194006149 DNA methylase; Region: N6_N4_Mtase; cl17433 246194006150 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 246194006151 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 246194006152 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246194006153 putative [4Fe-4S] binding site [ion binding]; other site 246194006154 putative molybdopterin cofactor binding site [chemical binding]; other site 246194006155 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 246194006156 molybdopterin cofactor binding site; other site 246194006157 Predicted permeases [General function prediction only]; Region: COG0679 246194006158 dipeptidase PepV; Reviewed; Region: PRK07318 246194006159 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 246194006160 active site 246194006161 metal binding site [ion binding]; metal-binding site 246194006162 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 246194006163 Carbon starvation protein CstA; Region: CstA; pfam02554 246194006164 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 246194006165 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 246194006166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194006167 active site 246194006168 phosphorylation site [posttranslational modification] 246194006169 intermolecular recognition site; other site 246194006170 dimerization interface [polypeptide binding]; other site 246194006171 LytTr DNA-binding domain; Region: LytTR; smart00850 246194006172 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 246194006173 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 246194006174 GAF domain; Region: GAF_3; pfam13492 246194006175 Histidine kinase; Region: His_kinase; pfam06580 246194006176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194006177 ATP binding site [chemical binding]; other site 246194006178 Mg2+ binding site [ion binding]; other site 246194006179 G-X-G motif; other site 246194006180 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246194006181 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246194006182 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 246194006183 putative active site [active] 246194006184 dimerization interface [polypeptide binding]; other site 246194006185 putative tRNAtyr binding site [nucleotide binding]; other site 246194006186 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 246194006187 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006188 Zn2+ binding site [ion binding]; other site 246194006189 Mg2+ binding site [ion binding]; other site 246194006190 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 246194006191 synthetase active site [active] 246194006192 NTP binding site [chemical binding]; other site 246194006193 metal binding site [ion binding]; metal-binding site 246194006194 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 246194006195 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 246194006196 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 246194006197 DHH family; Region: DHH; pfam01368 246194006198 DHHA1 domain; Region: DHHA1; pfam02272 246194006199 Protein of unknown function (DUF554); Region: DUF554; pfam04474 246194006200 EamA-like transporter family; Region: EamA; pfam00892 246194006201 EamA-like transporter family; Region: EamA; pfam00892 246194006202 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 246194006203 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 246194006204 active site 246194006205 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 246194006206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246194006207 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246194006208 Walker A/P-loop; other site 246194006209 ATP binding site [chemical binding]; other site 246194006210 Q-loop/lid; other site 246194006211 ABC transporter signature motif; other site 246194006212 Walker B; other site 246194006213 D-loop; other site 246194006214 H-loop/switch region; other site 246194006215 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246194006216 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246194006217 Walker A/P-loop; other site 246194006218 ATP binding site [chemical binding]; other site 246194006219 Q-loop/lid; other site 246194006220 ABC transporter signature motif; other site 246194006221 Walker B; other site 246194006222 D-loop; other site 246194006223 H-loop/switch region; other site 246194006224 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 246194006225 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246194006226 TM-ABC transporter signature motif; other site 246194006227 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246194006228 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246194006229 TM-ABC transporter signature motif; other site 246194006230 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 246194006231 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 246194006232 putative ligand binding site [chemical binding]; other site 246194006233 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246194006234 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246194006235 FtsX-like permease family; Region: FtsX; pfam02687 246194006236 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246194006237 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246194006238 Walker A/P-loop; other site 246194006239 ATP binding site [chemical binding]; other site 246194006240 Q-loop/lid; other site 246194006241 ABC transporter signature motif; other site 246194006242 Walker B; other site 246194006243 D-loop; other site 246194006244 H-loop/switch region; other site 246194006245 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 246194006246 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246194006247 lipoyl-biotinyl attachment site [posttranslational modification]; other site 246194006248 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246194006249 HlyD family secretion protein; Region: HlyD_3; pfam13437 246194006250 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 246194006251 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 246194006252 Yip1 domain; Region: Yip1; pfam04893 246194006253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194006254 Walker A/P-loop; other site 246194006255 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 246194006256 Predicted integral membrane protein [Function unknown]; Region: COG5658 246194006257 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 246194006258 SdpI/YhfL protein family; Region: SdpI; pfam13630 246194006259 Uncharacterized conserved protein [Function unknown]; Region: COG1633 246194006260 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 246194006261 diiron binding motif [ion binding]; other site 246194006262 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 246194006263 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 246194006264 enoyl-CoA hydratase; Provisional; Region: PRK06688 246194006265 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246194006266 substrate binding site [chemical binding]; other site 246194006267 oxyanion hole (OAH) forming residues; other site 246194006268 trimer interface [polypeptide binding]; other site 246194006269 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 246194006270 argininosuccinate lyase; Provisional; Region: PRK00855 246194006271 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 246194006272 active sites [active] 246194006273 tetramer interface [polypeptide binding]; other site 246194006274 argininosuccinate synthase; Provisional; Region: PRK13820 246194006275 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 246194006276 ANP binding site [chemical binding]; other site 246194006277 Substrate Binding Site II [chemical binding]; other site 246194006278 Substrate Binding Site I [chemical binding]; other site 246194006279 ornithine carbamoyltransferase; Provisional; Region: PRK00779 246194006280 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246194006281 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246194006282 acetylornithine aminotransferase; Provisional; Region: PRK02627 246194006283 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246194006284 inhibitor-cofactor binding pocket; inhibition site 246194006285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194006286 catalytic residue [active] 246194006287 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 246194006288 feedback inhibition sensing region; other site 246194006289 homohexameric interface [polypeptide binding]; other site 246194006290 carbamate kinase; Reviewed; Region: PRK12686 246194006291 nucleotide binding site [chemical binding]; other site 246194006292 N-acetyl-L-glutamate binding site [chemical binding]; other site 246194006293 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 246194006294 heterotetramer interface [polypeptide binding]; other site 246194006295 active site pocket [active] 246194006296 cleavage site 246194006297 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 246194006298 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246194006299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194006300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194006301 putative substrate translocation pore; other site 246194006302 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 246194006303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194006304 FeS/SAM binding site; other site 246194006305 hypothetical protein; Provisional; Region: PRK03881 246194006306 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 246194006307 AMMECR1; Region: AMMECR1; pfam01871 246194006308 OPT oligopeptide transporter protein; Region: OPT; cl14607 246194006309 putative oligopeptide transporter, OPT family; Region: TIGR00733 246194006310 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246194006311 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246194006312 active site 246194006313 metal binding site [ion binding]; metal-binding site 246194006314 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 246194006315 Ferritin-like domain; Region: Ferritin; pfam00210 246194006316 dinuclear metal binding motif [ion binding]; other site 246194006317 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 246194006318 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 246194006319 23S rRNA interface [nucleotide binding]; other site 246194006320 L3 interface [polypeptide binding]; other site 246194006321 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 246194006322 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246194006323 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246194006324 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 246194006325 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 246194006326 dimerization interface 3.5A [polypeptide binding]; other site 246194006327 active site 246194006328 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 246194006329 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 246194006330 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246194006331 Walker A/P-loop; other site 246194006332 ATP binding site [chemical binding]; other site 246194006333 Q-loop/lid; other site 246194006334 ABC transporter signature motif; other site 246194006335 Walker B; other site 246194006336 D-loop; other site 246194006337 H-loop/switch region; other site 246194006338 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 246194006339 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 246194006340 Walker A/P-loop; other site 246194006341 ATP binding site [chemical binding]; other site 246194006342 Q-loop/lid; other site 246194006343 ABC transporter signature motif; other site 246194006344 Walker B; other site 246194006345 D-loop; other site 246194006346 H-loop/switch region; other site 246194006347 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 246194006348 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 246194006349 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 246194006350 alphaNTD homodimer interface [polypeptide binding]; other site 246194006351 alphaNTD - beta interaction site [polypeptide binding]; other site 246194006352 alphaNTD - beta' interaction site [polypeptide binding]; other site 246194006353 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 246194006354 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 246194006355 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 246194006356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194006357 RNA binding surface [nucleotide binding]; other site 246194006358 30S ribosomal protein S11; Validated; Region: PRK05309 246194006359 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 246194006360 30S ribosomal protein S13; Region: bact_S13; TIGR03631 246194006361 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 246194006362 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 246194006363 rRNA binding site [nucleotide binding]; other site 246194006364 predicted 30S ribosome binding site; other site 246194006365 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 246194006366 RNA binding site [nucleotide binding]; other site 246194006367 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246194006368 active site 246194006369 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 246194006370 SecY translocase; Region: SecY; pfam00344 246194006371 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 246194006372 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 246194006373 23S rRNA binding site [nucleotide binding]; other site 246194006374 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 246194006375 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 246194006376 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 246194006377 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 246194006378 5S rRNA interface [nucleotide binding]; other site 246194006379 L27 interface [polypeptide binding]; other site 246194006380 23S rRNA interface [nucleotide binding]; other site 246194006381 L5 interface [polypeptide binding]; other site 246194006382 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 246194006383 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246194006384 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246194006385 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 246194006386 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 246194006387 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 246194006388 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 246194006389 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 246194006390 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 246194006391 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 246194006392 RNA binding site [nucleotide binding]; other site 246194006393 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 246194006394 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 246194006395 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 246194006396 23S rRNA interface [nucleotide binding]; other site 246194006397 putative translocon interaction site; other site 246194006398 signal recognition particle (SRP54) interaction site; other site 246194006399 L23 interface [polypeptide binding]; other site 246194006400 trigger factor interaction site; other site 246194006401 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 246194006402 23S rRNA interface [nucleotide binding]; other site 246194006403 5S rRNA interface [nucleotide binding]; other site 246194006404 putative antibiotic binding site [chemical binding]; other site 246194006405 L25 interface [polypeptide binding]; other site 246194006406 L27 interface [polypeptide binding]; other site 246194006407 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 246194006408 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 246194006409 G-X-X-G motif; other site 246194006410 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 246194006411 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 246194006412 putative translocon binding site; other site 246194006413 protein-rRNA interface [nucleotide binding]; other site 246194006414 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 246194006415 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 246194006416 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 246194006417 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 246194006418 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 246194006419 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 246194006420 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 246194006421 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 246194006422 elongation factor Tu; Reviewed; Region: PRK00049 246194006423 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 246194006424 G1 box; other site 246194006425 GEF interaction site [polypeptide binding]; other site 246194006426 GTP/Mg2+ binding site [chemical binding]; other site 246194006427 Switch I region; other site 246194006428 G2 box; other site 246194006429 G3 box; other site 246194006430 Switch II region; other site 246194006431 G4 box; other site 246194006432 G5 box; other site 246194006433 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 246194006434 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 246194006435 Antibiotic Binding Site [chemical binding]; other site 246194006436 elongation factor G; Reviewed; Region: PRK00007 246194006437 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 246194006438 G1 box; other site 246194006439 putative GEF interaction site [polypeptide binding]; other site 246194006440 GTP/Mg2+ binding site [chemical binding]; other site 246194006441 Switch I region; other site 246194006442 G2 box; other site 246194006443 G3 box; other site 246194006444 Switch II region; other site 246194006445 G4 box; other site 246194006446 G5 box; other site 246194006447 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246194006448 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246194006449 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246194006450 30S ribosomal protein S7; Validated; Region: PRK05302 246194006451 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 246194006452 S17 interaction site [polypeptide binding]; other site 246194006453 S8 interaction site; other site 246194006454 16S rRNA interaction site [nucleotide binding]; other site 246194006455 streptomycin interaction site [chemical binding]; other site 246194006456 23S rRNA interaction site [nucleotide binding]; other site 246194006457 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 246194006458 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 246194006459 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 246194006460 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 246194006461 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 246194006462 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 246194006463 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 246194006464 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 246194006465 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 246194006466 G-loop; other site 246194006467 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 246194006468 DNA binding site [nucleotide binding] 246194006469 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 246194006470 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 246194006471 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 246194006472 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 246194006473 RPB1 interaction site [polypeptide binding]; other site 246194006474 RPB10 interaction site [polypeptide binding]; other site 246194006475 RPB11 interaction site [polypeptide binding]; other site 246194006476 RPB3 interaction site [polypeptide binding]; other site 246194006477 RPB12 interaction site [polypeptide binding]; other site 246194006478 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 246194006479 peripheral dimer interface [polypeptide binding]; other site 246194006480 core dimer interface [polypeptide binding]; other site 246194006481 L10 interface [polypeptide binding]; other site 246194006482 L11 interface [polypeptide binding]; other site 246194006483 putative EF-Tu interaction site [polypeptide binding]; other site 246194006484 putative EF-G interaction site [polypeptide binding]; other site 246194006485 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 246194006486 23S rRNA interface [nucleotide binding]; other site 246194006487 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 246194006488 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 246194006489 mRNA/rRNA interface [nucleotide binding]; other site 246194006490 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 246194006491 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 246194006492 23S rRNA interface [nucleotide binding]; other site 246194006493 L7/L12 interface [polypeptide binding]; other site 246194006494 putative thiostrepton binding site; other site 246194006495 L25 interface [polypeptide binding]; other site 246194006496 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 246194006497 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 246194006498 putative homodimer interface [polypeptide binding]; other site 246194006499 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 246194006500 heterodimer interface [polypeptide binding]; other site 246194006501 homodimer interface [polypeptide binding]; other site 246194006502 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 246194006503 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 246194006504 elongation factor Tu; Reviewed; Region: PRK00049 246194006505 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 246194006506 G1 box; other site 246194006507 GEF interaction site [polypeptide binding]; other site 246194006508 GTP/Mg2+ binding site [chemical binding]; other site 246194006509 Switch I region; other site 246194006510 G2 box; other site 246194006511 G3 box; other site 246194006512 Switch II region; other site 246194006513 G4 box; other site 246194006514 G5 box; other site 246194006515 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 246194006516 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 246194006517 Antibiotic Binding Site [chemical binding]; other site 246194006518 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 246194006519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194006520 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246194006521 YacP-like NYN domain; Region: NYN_YacP; pfam05991 246194006522 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 246194006523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 246194006524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246194006525 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 246194006526 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 246194006527 dimerization interface [polypeptide binding]; other site 246194006528 active site 246194006529 metal binding site [ion binding]; metal-binding site 246194006530 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 246194006531 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246194006532 active site 246194006533 HIGH motif; other site 246194006534 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246194006535 KMSKS motif; other site 246194006536 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246194006537 tRNA binding surface [nucleotide binding]; other site 246194006538 anticodon binding site; other site 246194006539 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 246194006540 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 246194006541 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 246194006542 trimer interface [polypeptide binding]; other site 246194006543 active site 246194006544 substrate binding site [chemical binding]; other site 246194006545 CoA binding site [chemical binding]; other site 246194006546 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 246194006547 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 246194006548 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246194006549 active site 246194006550 HIGH motif; other site 246194006551 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246194006552 active site 246194006553 KMSKS motif; other site 246194006554 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 246194006555 homotrimer interaction site [polypeptide binding]; other site 246194006556 zinc binding site [ion binding]; other site 246194006557 CDP-binding sites; other site 246194006558 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 246194006559 substrate binding site; other site 246194006560 dimer interface; other site 246194006561 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 246194006562 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 246194006563 putative active site [active] 246194006564 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 246194006565 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 246194006566 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 246194006567 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 246194006568 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 246194006569 Helix-hairpin-helix motif; Region: HHH; pfam00633 246194006570 DNA repair protein RadA; Provisional; Region: PRK11823 246194006571 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 246194006572 Walker A motif/ATP binding site; other site 246194006573 ATP binding site [chemical binding]; other site 246194006574 Walker B motif; other site 246194006575 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246194006576 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246194006577 Clp amino terminal domain; Region: Clp_N; pfam02861 246194006578 Clp amino terminal domain; Region: Clp_N; pfam02861 246194006579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194006580 Walker A motif; other site 246194006581 ATP binding site [chemical binding]; other site 246194006582 Walker B motif; other site 246194006583 arginine finger; other site 246194006584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194006585 Walker A motif; other site 246194006586 ATP binding site [chemical binding]; other site 246194006587 Walker B motif; other site 246194006588 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246194006589 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 246194006590 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 246194006591 ADP binding site [chemical binding]; other site 246194006592 phosphagen binding site; other site 246194006593 substrate specificity loop; other site 246194006594 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 246194006595 UvrB/uvrC motif; Region: UVR; pfam02151 246194006596 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 246194006597 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 246194006598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246194006599 Walker A/P-loop; other site 246194006600 ATP binding site [chemical binding]; other site 246194006601 Q-loop/lid; other site 246194006602 ABC transporter signature motif; other site 246194006603 Walker B; other site 246194006604 D-loop; other site 246194006605 H-loop/switch region; other site 246194006606 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 246194006607 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246194006608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246194006609 Walker A/P-loop; other site 246194006610 ATP binding site [chemical binding]; other site 246194006611 Q-loop/lid; other site 246194006612 ABC transporter signature motif; other site 246194006613 Walker B; other site 246194006614 D-loop; other site 246194006615 H-loop/switch region; other site 246194006616 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 246194006617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246194006618 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 246194006619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194006620 dimer interface [polypeptide binding]; other site 246194006621 conserved gate region; other site 246194006622 putative PBP binding loops; other site 246194006623 ABC-ATPase subunit interface; other site 246194006624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246194006625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194006626 dimer interface [polypeptide binding]; other site 246194006627 conserved gate region; other site 246194006628 putative PBP binding loops; other site 246194006629 ABC-ATPase subunit interface; other site 246194006630 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 246194006631 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 246194006632 dimer interface [polypeptide binding]; other site 246194006633 putative anticodon binding site; other site 246194006634 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 246194006635 motif 1; other site 246194006636 active site 246194006637 motif 2; other site 246194006638 motif 3; other site 246194006639 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 246194006640 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 246194006641 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246194006642 Predicted dehydrogenase [General function prediction only]; Region: COG5322 246194006643 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 246194006644 NAD(P) binding pocket [chemical binding]; other site 246194006645 putative transcriptional regulator; Provisional; Region: tfx; cl17550 246194006646 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 246194006647 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 246194006648 FMN binding site [chemical binding]; other site 246194006649 active site 246194006650 catalytic residues [active] 246194006651 substrate binding site [chemical binding]; other site 246194006652 pantothenate kinase; Reviewed; Region: PRK13318 246194006653 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 246194006654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246194006655 dimerization interface [polypeptide binding]; other site 246194006656 putative Zn2+ binding site [ion binding]; other site 246194006657 putative DNA binding site [nucleotide binding]; other site 246194006658 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 246194006659 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 246194006660 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 246194006661 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 246194006662 dimerization interface [polypeptide binding]; other site 246194006663 active site 246194006664 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 246194006665 L-aspartate oxidase; Provisional; Region: PRK06175 246194006666 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246194006667 Quinolinate synthetase A protein; Region: NadA; pfam02445 246194006668 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 246194006669 tetramerization interface [polypeptide binding]; other site 246194006670 active site 246194006671 pantoate--beta-alanine ligase; Region: panC; TIGR00018 246194006672 Pantoate-beta-alanine ligase; Region: PanC; cd00560 246194006673 active site 246194006674 ATP-binding site [chemical binding]; other site 246194006675 pantoate-binding site; other site 246194006676 HXXH motif; other site 246194006677 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 246194006678 oligomerization interface [polypeptide binding]; other site 246194006679 active site 246194006680 metal binding site [ion binding]; metal-binding site 246194006681 Rossmann-like domain; Region: Rossmann-like; pfam10727 246194006682 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 246194006683 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 246194006684 catalytic center binding site [active] 246194006685 ATP binding site [chemical binding]; other site 246194006686 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 246194006687 homooctamer interface [polypeptide binding]; other site 246194006688 active site 246194006689 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 246194006690 dihydropteroate synthase; Region: DHPS; TIGR01496 246194006691 substrate binding pocket [chemical binding]; other site 246194006692 dimer interface [polypeptide binding]; other site 246194006693 inhibitor binding site; inhibition site 246194006694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006695 Zn2+ binding site [ion binding]; other site 246194006696 Mg2+ binding site [ion binding]; other site 246194006697 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 246194006698 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 246194006699 Potassium binding sites [ion binding]; other site 246194006700 Cesium cation binding sites [ion binding]; other site 246194006701 Predicted thioesterase [General function prediction only]; Region: COG5496 246194006702 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246194006703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246194006704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194006705 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246194006706 catalytic residues [active] 246194006707 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 246194006708 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 246194006709 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 246194006710 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 246194006711 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246194006712 active site 246194006713 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 246194006714 Uncharacterized conserved protein [Function unknown]; Region: COG2006 246194006715 Domain of unknown function (DUF362); Region: DUF362; pfam04015 246194006716 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194006717 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 246194006718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246194006719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246194006720 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 246194006721 putative dimerization interface [polypeptide binding]; other site 246194006722 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 246194006723 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246194006724 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 246194006725 catalytic triad [active] 246194006726 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 246194006727 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 246194006728 DsrC like protein; Region: DsrC; pfam04358 246194006729 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194006730 Cysteine-rich domain; Region: CCG; pfam02754 246194006731 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 246194006732 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 246194006733 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 246194006734 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246194006735 Cysteine-rich domain; Region: CCG; pfam02754 246194006736 diphthine synthase; Region: dph5; TIGR00522 246194006737 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 246194006738 active site 246194006739 SAM binding site [chemical binding]; other site 246194006740 homodimer interface [polypeptide binding]; other site 246194006741 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 246194006742 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246194006743 active site 246194006744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246194006745 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 246194006746 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246194006747 4Fe-4S binding domain; Region: Fer4; pfam00037 246194006748 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 246194006749 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246194006750 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 246194006751 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 246194006752 acyl-activating enzyme (AAE) consensus motif; other site 246194006753 putative AMP binding site [chemical binding]; other site 246194006754 putative active site [active] 246194006755 putative CoA binding site [chemical binding]; other site 246194006756 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246194006757 CoenzymeA binding site [chemical binding]; other site 246194006758 subunit interaction site [polypeptide binding]; other site 246194006759 PHB binding site; other site 246194006760 Iron permease FTR1 family; Region: FTR1; cl00475 246194006761 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246194006762 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246194006763 putative dimer interface [polypeptide binding]; other site 246194006764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246194006765 putative substrate translocation pore; other site 246194006766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246194006767 EDD domain protein, DegV family; Region: DegV; TIGR00762 246194006768 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 246194006769 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246194006770 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246194006771 putative dimer interface [polypeptide binding]; other site 246194006772 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 246194006773 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 246194006774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246194006775 dimer interface [polypeptide binding]; other site 246194006776 conserved gate region; other site 246194006777 ABC-ATPase subunit interface; other site 246194006778 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 246194006779 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 246194006780 Walker A/P-loop; other site 246194006781 ATP binding site [chemical binding]; other site 246194006782 Q-loop/lid; other site 246194006783 ABC transporter signature motif; other site 246194006784 Walker B; other site 246194006785 D-loop; other site 246194006786 H-loop/switch region; other site 246194006787 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 246194006788 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246194006789 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246194006790 Walker A/P-loop; other site 246194006791 ATP binding site [chemical binding]; other site 246194006792 Q-loop/lid; other site 246194006793 ABC transporter signature motif; other site 246194006794 Walker B; other site 246194006795 D-loop; other site 246194006796 H-loop/switch region; other site 246194006797 Putative zinc-finger; Region: zf-HC2; pfam13490 246194006798 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 246194006799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246194006800 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246194006801 Short C-terminal domain; Region: SHOCT; pfam09851 246194006802 Predicted membrane protein [Function unknown]; Region: COG3462 246194006803 Short C-terminal domain; Region: SHOCT; pfam09851 246194006804 Short C-terminal domain; Region: SHOCT; pfam09851 246194006805 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 246194006806 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 246194006807 Sporulation and spore germination; Region: Germane; pfam10646 246194006808 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246194006809 cell division protein FtsA; Region: ftsA; TIGR01174 246194006810 Cell division protein FtsA; Region: FtsA; smart00842 246194006811 Cell division protein FtsA; Region: FtsA; pfam14450 246194006812 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 246194006813 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 246194006814 active site 246194006815 NTP binding site [chemical binding]; other site 246194006816 metal binding triad [ion binding]; metal-binding site 246194006817 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 246194006818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006819 Zn2+ binding site [ion binding]; other site 246194006820 Mg2+ binding site [ion binding]; other site 246194006821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006822 Zn2+ binding site [ion binding]; other site 246194006823 Mg2+ binding site [ion binding]; other site 246194006824 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246194006825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006826 Zn2+ binding site [ion binding]; other site 246194006827 Mg2+ binding site [ion binding]; other site 246194006828 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 246194006829 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 246194006830 Walker A/P-loop; other site 246194006831 ATP binding site [chemical binding]; other site 246194006832 Q-loop/lid; other site 246194006833 Walker B; other site 246194006834 D-loop; other site 246194006835 H-loop/switch region; other site 246194006836 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 246194006837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246194006838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194006839 Walker A/P-loop; other site 246194006840 ATP binding site [chemical binding]; other site 246194006841 Q-loop/lid; other site 246194006842 ABC transporter signature motif; other site 246194006843 Walker B; other site 246194006844 D-loop; other site 246194006845 H-loop/switch region; other site 246194006846 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 246194006847 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 246194006848 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 246194006849 Predicted transcriptional regulator [Transcription]; Region: COG1959 246194006850 Transcriptional regulator; Region: Rrf2; pfam02082 246194006851 RmuC family; Region: RmuC; pfam02646 246194006852 biotin synthase; Provisional; Region: PRK07094 246194006853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194006854 FeS/SAM binding site; other site 246194006855 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 246194006856 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 246194006857 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 246194006858 putative active site [active] 246194006859 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 246194006860 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 246194006861 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 246194006862 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 246194006863 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 246194006864 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246194006865 putative transport protein YifK; Provisional; Region: PRK10746 246194006866 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 246194006867 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 246194006868 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 246194006869 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 246194006870 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 246194006871 putative L-serine binding site [chemical binding]; other site 246194006872 threonine dehydratase; Provisional; Region: PRK08198 246194006873 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246194006874 tetramer interface [polypeptide binding]; other site 246194006875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194006876 catalytic residue [active] 246194006877 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 246194006878 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246194006879 homotrimer interaction site [polypeptide binding]; other site 246194006880 putative active site [active] 246194006881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 246194006882 YheO-like PAS domain; Region: PAS_6; pfam08348 246194006883 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 246194006884 DNA-binding interface [nucleotide binding]; DNA binding site 246194006885 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 246194006886 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 246194006887 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 246194006888 active site 246194006889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246194006890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246194006891 metal binding site [ion binding]; metal-binding site 246194006892 active site 246194006893 I-site; other site 246194006894 Repair protein; Region: Repair_PSII; pfam04536 246194006895 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 246194006896 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246194006897 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246194006898 DGC domain; Region: DGC; pfam08859 246194006899 Protein of unknown function, DUF606; Region: DUF606; pfam04657 246194006900 Coat F domain; Region: Coat_F; pfam07875 246194006901 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 246194006902 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 246194006903 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 246194006904 putative oxidoreductase FixC; Provisional; Region: PRK10157 246194006905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246194006906 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246194006907 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246194006908 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246194006909 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246194006910 Ligand binding site [chemical binding]; other site 246194006911 Electron transfer flavoprotein domain; Region: ETF; pfam01012 246194006912 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 246194006913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194006914 FeS/SAM binding site; other site 246194006915 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 246194006916 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 246194006917 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194006918 active site 246194006919 NTP binding site [chemical binding]; other site 246194006920 metal binding triad [ion binding]; metal-binding site 246194006921 antibiotic binding site [chemical binding]; other site 246194006922 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246194006923 putative active site [active] 246194006924 Bacterial SH3 domain; Region: SH3_3; pfam08239 246194006925 Bacterial SH3 domain; Region: SH3_3; pfam08239 246194006926 Bacterial SH3 domain; Region: SH3_3; pfam08239 246194006927 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246194006928 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246194006929 active site 246194006930 metal binding site [ion binding]; metal-binding site 246194006931 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246194006932 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246194006933 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 246194006934 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 246194006935 active site 246194006936 metal binding site [ion binding]; metal-binding site 246194006937 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246194006938 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 246194006939 active site 246194006940 metal binding site [ion binding]; metal-binding site 246194006941 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246194006942 Bacterial SH3 domain; Region: SH3_3; pfam08239 246194006943 Bacterial SH3 domain; Region: SH3_3; cl17532 246194006944 HAMP domain; Region: HAMP; pfam00672 246194006945 dimerization interface [polypeptide binding]; other site 246194006946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246194006947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246194006948 dimer interface [polypeptide binding]; other site 246194006949 putative CheW interface [polypeptide binding]; other site 246194006950 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 246194006951 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246194006952 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246194006953 Zn2+ binding site [ion binding]; other site 246194006954 Mg2+ binding site [ion binding]; other site 246194006955 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246194006956 putative active site [active] 246194006957 HEPN domain; Region: HEPN; pfam05168 246194006958 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194006959 active site 246194006960 NTP binding site [chemical binding]; other site 246194006961 metal binding triad [ion binding]; metal-binding site 246194006962 antibiotic binding site [chemical binding]; other site 246194006963 YcfA-like protein; Region: YcfA; pfam07927 246194006964 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 246194006965 PIN domain; Region: PIN_3; pfam13470 246194006966 Helix-turn-helix domain; Region: HTH_38; pfam13936 246194006967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246194006968 Integrase core domain; Region: rve; pfam00665 246194006969 Transposase; Region: DEDD_Tnp_IS110; pfam01548 246194006970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246194006971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 246194006972 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 246194006973 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 246194006974 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 246194006975 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246194006976 putative active site [active] 246194006977 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246194006978 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246194006979 Homeodomain-like domain; Region: HTH_32; pfam13565 246194006980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 246194006981 Integrase core domain; Region: rve; pfam00665 246194006982 Integrase core domain; Region: rve_3; pfam13683 246194006983 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 246194006984 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 246194006985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194006986 Walker A motif; other site 246194006987 ATP binding site [chemical binding]; other site 246194006988 Walker B motif; other site 246194006989 arginine finger; other site 246194006990 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246194006991 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 246194006992 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 246194006993 oligomeric interface; other site 246194006994 putative active site [active] 246194006995 homodimer interface [polypeptide binding]; other site 246194006996 rod shape-determining protein Mbl; Provisional; Region: PRK13928 246194006997 MreB and similar proteins; Region: MreB_like; cd10225 246194006998 nucleotide binding site [chemical binding]; other site 246194006999 Mg binding site [ion binding]; other site 246194007000 putative protofilament interaction site [polypeptide binding]; other site 246194007001 RodZ interaction site [polypeptide binding]; other site 246194007002 Stage III sporulation protein D; Region: SpoIIID; pfam12116 246194007003 Uncharacterized conserved protein [Function unknown]; Region: COG2361 246194007004 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246194007005 active site 246194007006 NTP binding site [chemical binding]; other site 246194007007 metal binding triad [ion binding]; metal-binding site 246194007008 antibiotic binding site [chemical binding]; other site 246194007009 PIN domain; Region: PIN_3; cl17397 246194007010 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 246194007011 Stage II sporulation protein; Region: SpoIID; pfam08486 246194007012 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 246194007013 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 246194007014 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 246194007015 hinge; other site 246194007016 active site 246194007017 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 246194007018 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 246194007019 gamma subunit interface [polypeptide binding]; other site 246194007020 epsilon subunit interface [polypeptide binding]; other site 246194007021 LBP interface [polypeptide binding]; other site 246194007022 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 246194007023 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246194007024 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 246194007025 alpha subunit interaction interface [polypeptide binding]; other site 246194007026 Walker A motif; other site 246194007027 ATP binding site [chemical binding]; other site 246194007028 Walker B motif; other site 246194007029 inhibitor binding site; inhibition site 246194007030 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246194007031 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 246194007032 core domain interface [polypeptide binding]; other site 246194007033 delta subunit interface [polypeptide binding]; other site 246194007034 epsilon subunit interface [polypeptide binding]; other site 246194007035 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 246194007036 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246194007037 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 246194007038 beta subunit interaction interface [polypeptide binding]; other site 246194007039 Walker A motif; other site 246194007040 ATP binding site [chemical binding]; other site 246194007041 Walker B motif; other site 246194007042 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246194007043 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 246194007044 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 246194007045 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 246194007046 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 246194007047 ATP synthase subunit C; Region: ATP-synt_C; cl00466 246194007048 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 246194007049 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 246194007050 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 246194007051 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 246194007052 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 246194007053 active site 246194007054 homodimer interface [polypeptide binding]; other site 246194007055 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 246194007056 homodimer interface [polypeptide binding]; other site 246194007057 metal binding site [ion binding]; metal-binding site 246194007058 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 246194007059 catalytic motif [active] 246194007060 Zn binding site [ion binding]; other site 246194007061 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 246194007062 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 246194007063 dimer interface [polypeptide binding]; other site 246194007064 active site 246194007065 glycine-pyridoxal phosphate binding site [chemical binding]; other site 246194007066 folate binding site [chemical binding]; other site 246194007067 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 246194007068 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 246194007069 Low molecular weight phosphatase family; Region: LMWPc; cd00115 246194007070 active site 246194007071 Domain of unknown function DUF; Region: DUF204; pfam02659 246194007072 Domain of unknown function DUF; Region: DUF204; pfam02659 246194007073 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 246194007074 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 246194007075 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 246194007076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194007077 S-adenosylmethionine binding site [chemical binding]; other site 246194007078 peptide chain release factor 1; Validated; Region: prfA; PRK00591 246194007079 This domain is found in peptide chain release factors; Region: PCRF; smart00937 246194007080 RF-1 domain; Region: RF-1; pfam00472 246194007081 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 246194007082 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 246194007083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246194007084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246194007085 dimerization interface [polypeptide binding]; other site 246194007086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246194007087 dimer interface [polypeptide binding]; other site 246194007088 phosphorylation site [posttranslational modification] 246194007089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194007090 ATP binding site [chemical binding]; other site 246194007091 Mg2+ binding site [ion binding]; other site 246194007092 G-X-G motif; other site 246194007093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246194007094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246194007095 active site 246194007096 phosphorylation site [posttranslational modification] 246194007097 intermolecular recognition site; other site 246194007098 dimerization interface [polypeptide binding]; other site 246194007099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246194007100 DNA binding site [nucleotide binding] 246194007101 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 246194007102 AMIN domain; Region: AMIN; pfam11741 246194007103 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246194007104 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246194007105 active site 246194007106 metal binding site [ion binding]; metal-binding site 246194007107 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 246194007108 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 246194007109 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 246194007110 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246194007111 thiosulfate reductase PhsA; Provisional; Region: PRK15488 246194007112 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 246194007113 putative [Fe4-S4] binding site [ion binding]; other site 246194007114 putative molybdopterin cofactor binding site [chemical binding]; other site 246194007115 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 246194007116 putative molybdopterin cofactor binding site; other site 246194007117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246194007118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246194007119 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 246194007120 putative dimerization interface [polypeptide binding]; other site 246194007121 putative inner membrane protein; Provisional; Region: PRK11099 246194007122 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 246194007123 CPxP motif; other site 246194007124 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 246194007125 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 246194007126 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 246194007127 active site 246194007128 substrate binding site [chemical binding]; other site 246194007129 metal binding site [ion binding]; metal-binding site 246194007130 Predicted membrane protein [Function unknown]; Region: COG2323 246194007131 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 246194007132 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 246194007133 active site 246194007134 tetramer interface; other site 246194007135 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 246194007136 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 246194007137 active site 246194007138 metal binding site [ion binding]; metal-binding site 246194007139 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 246194007140 active site 246194007141 metal-binding site 246194007142 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 246194007143 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 246194007144 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 246194007145 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 246194007146 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 246194007147 Mg++ binding site [ion binding]; other site 246194007148 putative catalytic motif [active] 246194007149 substrate binding site [chemical binding]; other site 246194007150 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 246194007151 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 246194007152 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 246194007153 putative active site [active] 246194007154 putative metal binding site [ion binding]; other site 246194007155 Transcriptional regulator [Transcription]; Region: LytR; COG1316 246194007156 Bacterial SH3 domain; Region: SH3_3; pfam08239 246194007157 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 246194007158 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 246194007159 oligomer interface [polypeptide binding]; other site 246194007160 metal binding site [ion binding]; metal-binding site 246194007161 metal binding site [ion binding]; metal-binding site 246194007162 putative Cl binding site [ion binding]; other site 246194007163 aspartate ring; other site 246194007164 basic sphincter; other site 246194007165 hydrophobic gate; other site 246194007166 periplasmic entrance; other site 246194007167 Rubredoxin [Energy production and conversion]; Region: COG1773 246194007168 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 246194007169 iron binding site [ion binding]; other site 246194007170 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 246194007171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246194007172 Rubredoxin; Region: Rubredoxin; pfam00301 246194007173 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 246194007174 iron binding site [ion binding]; other site 246194007175 Rubrerythrin [Energy production and conversion]; Region: COG1592 246194007176 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 246194007177 binuclear metal center [ion binding]; other site 246194007178 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 246194007179 iron binding site [ion binding]; other site 246194007180 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 246194007181 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 246194007182 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 246194007183 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246194007184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246194007185 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 246194007186 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 246194007187 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 246194007188 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246194007189 dinuclear metal binding motif [ion binding]; other site 246194007190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246194007191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246194007192 active site 246194007193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246194007194 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246194007195 active site 246194007196 YabG peptidase U57; Region: Peptidase_U57; pfam05582 246194007197 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 246194007198 Protein of unknown function (DUF458); Region: DUF458; pfam04308 246194007199 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 246194007200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246194007201 S-adenosylmethionine binding site [chemical binding]; other site 246194007202 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246194007203 Domain of unknown function (DUF348); Region: DUF348; pfam03990 246194007204 G5 domain; Region: G5; pfam07501 246194007205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 246194007206 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 246194007207 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 246194007208 homodimer interface [polypeptide binding]; other site 246194007209 Walker A motif; other site 246194007210 ATP binding site [chemical binding]; other site 246194007211 hydroxycobalamin binding site [chemical binding]; other site 246194007212 Walker B motif; other site 246194007213 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 246194007214 active site 246194007215 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 246194007216 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 246194007217 active site 246194007218 HIGH motif; other site 246194007219 KMSKS motif; other site 246194007220 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 246194007221 tRNA binding surface [nucleotide binding]; other site 246194007222 anticodon binding site; other site 246194007223 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 246194007224 dimer interface [polypeptide binding]; other site 246194007225 putative tRNA-binding site [nucleotide binding]; other site 246194007226 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 246194007227 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246194007228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246194007229 binding surface 246194007230 TPR motif; other site 246194007231 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246194007232 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246194007233 Peptidase family M23; Region: Peptidase_M23; pfam01551 246194007234 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 246194007235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246194007236 FeS/SAM binding site; other site 246194007237 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246194007238 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 246194007239 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 246194007240 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 246194007241 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 246194007242 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 246194007243 active site 246194007244 metal binding site [ion binding]; metal-binding site 246194007245 interdomain interaction site; other site 246194007246 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 246194007247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 246194007248 Integrase core domain; Region: rve; pfam00665 246194007249 Integrase core domain; Region: rve_3; pfam13683 246194007250 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 246194007251 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 246194007252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194007253 Walker A motif; other site 246194007254 ATP binding site [chemical binding]; other site 246194007255 Walker B motif; other site 246194007256 arginine finger; other site 246194007257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246194007258 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 246194007259 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 246194007260 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 246194007261 TIGR02687 family protein; Region: TIGR02687 246194007262 PglZ domain; Region: PglZ; pfam08665 246194007263 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246194007264 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 246194007265 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 246194007266 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 246194007267 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246194007268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246194007269 active site 246194007270 DNA binding site [nucleotide binding] 246194007271 Int/Topo IB signature motif; other site 246194007272 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246194007273 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 246194007274 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 246194007275 homodimer interface [polypeptide binding]; other site 246194007276 substrate-cofactor binding pocket; other site 246194007277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194007278 catalytic residue [active] 246194007279 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 246194007280 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 246194007281 GDP-binding site [chemical binding]; other site 246194007282 ACT binding site; other site 246194007283 IMP binding site; other site 246194007284 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 246194007285 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246194007286 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 246194007287 recombination protein RecR; Reviewed; Region: recR; PRK00076 246194007288 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 246194007289 RecR protein; Region: RecR; pfam02132 246194007290 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 246194007291 putative active site [active] 246194007292 putative metal-binding site [ion binding]; other site 246194007293 tetramer interface [polypeptide binding]; other site 246194007294 hypothetical protein; Validated; Region: PRK00153 246194007295 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 246194007296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194007297 Walker A motif; other site 246194007298 ATP binding site [chemical binding]; other site 246194007299 DNA polymerase III subunit delta'; Validated; Region: PRK08485 246194007300 Walker B motif; other site 246194007301 arginine finger; other site 246194007302 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 246194007303 Protein of unknown function (DUF503); Region: DUF503; pfam04456 246194007304 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 246194007305 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 246194007306 trimer interface [polypeptide binding]; other site 246194007307 active site 246194007308 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246194007309 nucleoside/Zn binding site; other site 246194007310 dimer interface [polypeptide binding]; other site 246194007311 catalytic motif [active] 246194007312 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 246194007313 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246194007314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246194007315 catalytic residue [active] 246194007316 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 246194007317 CPxP motif; other site 246194007318 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246194007319 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 246194007320 4Fe-4S binding domain; Region: Fer4; pfam00037 246194007321 4Fe-4S binding domain; Region: Fer4; pfam00037 246194007322 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 246194007323 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 246194007324 ATP binding site [chemical binding]; other site 246194007325 substrate interface [chemical binding]; other site 246194007326 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 246194007327 thiS-thiF/thiG interaction site; other site 246194007328 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 246194007329 ATP-sulfurylase; Region: ATPS; cd00517 246194007330 active site 246194007331 HXXH motif; other site 246194007332 flexible loop; other site 246194007333 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 246194007334 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 246194007335 L-aspartate oxidase; Provisional; Region: PRK06175 246194007336 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246194007337 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246194007338 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 246194007339 ligand-binding site [chemical binding]; other site 246194007340 seryl-tRNA synthetase; Provisional; Region: PRK05431 246194007341 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 246194007342 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 246194007343 dimer interface [polypeptide binding]; other site 246194007344 active site 246194007345 motif 1; other site 246194007346 motif 2; other site 246194007347 motif 3; other site 246194007348 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 246194007349 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 246194007350 ligand binding site [chemical binding]; other site 246194007351 NAD binding site [chemical binding]; other site 246194007352 dimerization interface [polypeptide binding]; other site 246194007353 catalytic site [active] 246194007354 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 246194007355 putative L-serine binding site [chemical binding]; other site 246194007356 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 246194007357 homodimer interface [polypeptide binding]; other site 246194007358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246194007359 catalytic residue [active] 246194007360 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 246194007361 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 246194007362 predicted active site [active] 246194007363 catalytic triad [active] 246194007364 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 246194007365 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 246194007366 active site 246194007367 multimer interface [polypeptide binding]; other site 246194007368 DNA gyrase subunit A; Validated; Region: PRK05560 246194007369 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246194007370 CAP-like domain; other site 246194007371 active site 246194007372 primary dimer interface [polypeptide binding]; other site 246194007373 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246194007374 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246194007375 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246194007376 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246194007377 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246194007378 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246194007379 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 246194007380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246194007381 Mg2+ binding site [ion binding]; other site 246194007382 G-X-G motif; other site 246194007383 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246194007384 anchoring element; other site 246194007385 dimer interface [polypeptide binding]; other site 246194007386 ATP binding site [chemical binding]; other site 246194007387 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 246194007388 active site 246194007389 putative metal-binding site [ion binding]; other site 246194007390 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246194007391 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 246194007392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194007393 Walker A/P-loop; other site 246194007394 ATP binding site [chemical binding]; other site 246194007395 Q-loop/lid; other site 246194007396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246194007397 ABC transporter signature motif; other site 246194007398 Walker B; other site 246194007399 D-loop; other site 246194007400 H-loop/switch region; other site 246194007401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246194007402 RNA binding surface [nucleotide binding]; other site 246194007403 DNA polymerase III subunit beta; Validated; Region: PRK05643 246194007404 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 246194007405 putative DNA binding surface [nucleotide binding]; other site 246194007406 dimer interface [polypeptide binding]; other site 246194007407 beta-clamp/clamp loader binding surface; other site 246194007408 beta-clamp/translesion DNA polymerase binding surface; other site 246194007409 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 246194007410 DnaA N-terminal domain; Region: DnaA_N; pfam11638 246194007411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246194007412 Walker A motif; other site 246194007413 ATP binding site [chemical binding]; other site 246194007414 Walker B motif; other site 246194007415 arginine finger; other site 246194007416 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 246194007417 DnaA box-binding interface [nucleotide binding]; other site