-- dump date 20140619_025736 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1231626000001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626000002 Integrase core domain; Region: rve; pfam00665 1231626000003 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1231626000004 excinuclease ABC subunit B; Provisional; Region: PRK05298 1231626000005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1231626000006 ATP binding site [chemical binding]; other site 1231626000007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1231626000008 nucleotide binding region [chemical binding]; other site 1231626000009 ATP-binding site [chemical binding]; other site 1231626000010 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1231626000011 UvrB/uvrC motif; Region: UVR; pfam02151 1231626000012 Wiskott Aldrich syndrome homology region 2; Region: WH2; smart00246 1231626000013 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1231626000014 active site 1231626000015 8-oxo-dGMP binding site [chemical binding]; other site 1231626000016 nudix motif; other site 1231626000017 metal binding site [ion binding]; metal-binding site 1231626000018 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1231626000019 Src homology 2 (SH2) domain; Region: SH2; cl15255 1231626000020 phosphotyrosine binding pocket [polypeptide binding]; other site 1231626000021 hydrophobic binding pocket [polypeptide binding]; other site 1231626000022 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1231626000023 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1231626000024 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1231626000025 dimer interface [polypeptide binding]; other site 1231626000026 putative anticodon binding site; other site 1231626000027 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1231626000028 motif 1; other site 1231626000029 active site 1231626000030 motif 2; other site 1231626000031 motif 3; other site 1231626000032 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1231626000033 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1231626000034 DNA binding residues [nucleotide binding] 1231626000035 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1231626000036 Peptidase family M23; Region: Peptidase_M23; pfam01551 1231626000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1231626000038 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1231626000039 nucleotide binding site [chemical binding]; other site 1231626000040 NEF interaction site [polypeptide binding]; other site 1231626000041 SBD interface [polypeptide binding]; other site 1231626000042 MutS domain III; Region: MutS_III; cl17822 1231626000043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626000044 Walker A/P-loop; other site 1231626000045 ATP binding site [chemical binding]; other site 1231626000046 Q-loop/lid; other site 1231626000047 ABC transporter signature motif; other site 1231626000048 Walker B; other site 1231626000049 D-loop; other site 1231626000050 H-loop/switch region; other site 1231626000051 TLC ATP/ADP transporter; Region: TLC; cl03940 1231626000052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626000053 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1231626000054 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000055 Integrase core domain; Region: rve; pfam00665 1231626000056 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1231626000057 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1231626000058 putative active site [active] 1231626000059 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 1231626000060 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1231626000061 Part of AAA domain; Region: AAA_19; pfam13245 1231626000062 Family description; Region: UvrD_C_2; pfam13538 1231626000063 PGAP1-like protein; Region: PGAP1; pfam07819 1231626000064 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1231626000065 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1231626000066 active site 1231626000067 NTP binding site [chemical binding]; other site 1231626000068 metal binding triad [ion binding]; metal-binding site 1231626000069 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1231626000070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1231626000071 Zn2+ binding site [ion binding]; other site 1231626000072 Mg2+ binding site [ion binding]; other site 1231626000073 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1231626000074 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1231626000075 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1231626000076 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 1231626000077 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 1231626000078 active site 1231626000079 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1231626000080 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1231626000081 putative dimer interface [polypeptide binding]; other site 1231626000082 putative anticodon binding site; other site 1231626000083 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1231626000084 homodimer interface [polypeptide binding]; other site 1231626000085 motif 1; other site 1231626000086 motif 2; other site 1231626000087 active site 1231626000088 motif 3; other site 1231626000089 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1231626000090 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1231626000091 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1231626000092 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1231626000093 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000094 Integrase core domain; Region: rve; pfam00665 1231626000095 Integrase core domain; Region: rve; pfam00665 1231626000096 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1231626000097 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1231626000098 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 1231626000099 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1231626000100 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1231626000101 homoserine kinase; Provisional; Region: PTZ00299 1231626000102 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626000103 Na binding site [ion binding]; other site 1231626000104 transient-receptor-potential calcium channel protein; Region: trp; TIGR00870 1231626000105 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626000106 Helix-turn-helix domain; Region: HTH_28; pfam13518 1231626000107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1231626000108 Integrase core domain; Region: rve; pfam00665 1231626000109 Integrase core domain; Region: rve_3; pfam13683 1231626000110 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1231626000111 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1231626000112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1231626000113 FeS/SAM binding site; other site 1231626000114 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1231626000115 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1231626000116 active site 1231626000117 HslU subunit interaction site [polypeptide binding]; other site 1231626000118 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1231626000119 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1231626000120 E3 interaction surface; other site 1231626000121 lipoyl attachment site [posttranslational modification]; other site 1231626000122 e3 binding domain; Region: E3_binding; pfam02817 1231626000123 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1231626000124 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1231626000125 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1231626000126 Ligand Binding Site [chemical binding]; other site 1231626000127 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1231626000128 DNA repair protein RadA; Provisional; Region: PRK11823 1231626000129 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1231626000130 Walker A motif/ATP binding site; other site 1231626000131 ATP binding site [chemical binding]; other site 1231626000132 Walker B motif; other site 1231626000133 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1231626000134 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1231626000135 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1231626000136 Glycoprotease family; Region: Peptidase_M22; pfam00814 1231626000137 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1231626000138 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1231626000139 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1231626000140 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1231626000141 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1231626000142 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1231626000143 active site 1231626000144 HIGH motif; other site 1231626000145 KMSKS motif; other site 1231626000146 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1231626000147 tRNA binding surface [nucleotide binding]; other site 1231626000148 anticodon binding site; other site 1231626000149 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000150 Integrase core domain; Region: rve; pfam00665 1231626000151 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1231626000152 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1231626000153 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1231626000154 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1231626000155 putative acyl-acceptor binding pocket; other site 1231626000156 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1231626000157 Ubiquitin-interacting motif; Region: UIM; smart00726 1231626000158 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1231626000159 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1231626000160 Ligand binding site; other site 1231626000161 Putative Catalytic site; other site 1231626000162 DXD motif; other site 1231626000163 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1231626000164 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1231626000165 GIY-YIG motif/motif A; other site 1231626000166 active site 1231626000167 catalytic site [active] 1231626000168 putative DNA binding site [nucleotide binding]; other site 1231626000169 metal binding site [ion binding]; metal-binding site 1231626000170 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1231626000171 Ribosome-binding factor A; Region: RBFA; pfam02033 1231626000172 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1231626000173 triosephosphate isomerase; Provisional; Region: PRK14565 1231626000174 substrate binding site [chemical binding]; other site 1231626000175 dimer interface [polypeptide binding]; other site 1231626000176 catalytic triad [active] 1231626000177 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 1231626000178 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1231626000179 alpha subunit interface [polypeptide binding]; other site 1231626000180 TPP binding site [chemical binding]; other site 1231626000181 heterodimer interface [polypeptide binding]; other site 1231626000182 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1231626000183 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1231626000184 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1231626000185 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1231626000186 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1231626000187 Septum formation initiator; Region: DivIC; cl17659 1231626000188 DNA recombination protein RmuC; Provisional; Region: PRK10361 1231626000189 RmuC family; Region: RmuC; pfam02646 1231626000190 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1231626000191 elongation factor G; Reviewed; Region: PRK12739 1231626000192 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1231626000193 G1 box; other site 1231626000194 putative GEF interaction site [polypeptide binding]; other site 1231626000195 GTP/Mg2+ binding site [chemical binding]; other site 1231626000196 Switch I region; other site 1231626000197 G2 box; other site 1231626000198 G3 box; other site 1231626000199 Switch II region; other site 1231626000200 G4 box; other site 1231626000201 G5 box; other site 1231626000202 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1231626000203 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1231626000204 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1231626000205 30S ribosomal protein S7; Validated; Region: PRK05302 1231626000206 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1231626000207 S17 interaction site [polypeptide binding]; other site 1231626000208 S8 interaction site; other site 1231626000209 16S rRNA interaction site [nucleotide binding]; other site 1231626000210 streptomycin interaction site [chemical binding]; other site 1231626000211 23S rRNA interaction site [nucleotide binding]; other site 1231626000212 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1231626000213 Rhomboid family; Region: Rhomboid; cl11446 1231626000214 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626000215 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626000216 Na binding site [ion binding]; other site 1231626000217 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1231626000218 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1231626000219 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 1231626000220 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1231626000221 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1231626000222 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1231626000223 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1231626000224 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1231626000225 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1231626000226 RNA binding site [nucleotide binding]; other site 1231626000227 active site 1231626000228 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626000229 Helix-turn-helix domain; Region: HTH_28; pfam13518 1231626000230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1231626000231 Integrase core domain; Region: rve; pfam00665 1231626000232 Integrase core domain; Region: rve_3; pfam13683 1231626000233 MULE transposase domain; Region: MULE; pfam10551 1231626000234 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1231626000235 active site 1231626000236 putative DNA-binding cleft [nucleotide binding]; other site 1231626000237 dimer interface [polypeptide binding]; other site 1231626000238 Transposase; Region: HTH_Tnp_1; cl17663 1231626000239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626000240 HTH-like domain; Region: HTH_21; pfam13276 1231626000241 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000242 Integrase core domain; Region: rve; pfam00665 1231626000243 Integrase core domain; Region: rve_3; pfam13683 1231626000244 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1231626000245 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1231626000246 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1231626000247 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000248 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626000249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000250 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000252 Ankyrin repeat; Region: Ank; pfam00023 1231626000253 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1231626000254 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000255 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626000256 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626000257 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000258 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000259 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000260 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626000261 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000262 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000263 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000264 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626000265 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1231626000266 Phosphoglycerate kinase; Region: PGK; pfam00162 1231626000267 substrate binding site [chemical binding]; other site 1231626000268 hinge regions; other site 1231626000269 ADP binding site [chemical binding]; other site 1231626000270 catalytic site [active] 1231626000271 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1231626000272 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1231626000273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626000274 Walker A motif; other site 1231626000275 ATP binding site [chemical binding]; other site 1231626000276 Walker B motif; other site 1231626000277 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1231626000278 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1231626000279 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1231626000280 active site 1231626000281 HIGH motif; other site 1231626000282 dimer interface [polypeptide binding]; other site 1231626000283 KMSKS motif; other site 1231626000284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1231626000285 RNA binding surface [nucleotide binding]; other site 1231626000286 Domain of unknown function (DUF3506); Region: DUF3506; pfam12014 1231626000287 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1231626000288 RuvA N terminal domain; Region: RuvA_N; pfam01330 1231626000289 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1231626000290 membrane protein insertase; Provisional; Region: PRK01318 1231626000291 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1231626000292 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1231626000293 dimer interface [polypeptide binding]; other site 1231626000294 substrate binding site [chemical binding]; other site 1231626000295 metal binding sites [ion binding]; metal-binding site 1231626000296 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1231626000297 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 1231626000298 CAP-like domain; other site 1231626000299 active site 1231626000300 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1231626000301 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1231626000302 EamA-like transporter family; Region: EamA; pfam00892 1231626000303 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1231626000304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1231626000305 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1231626000306 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1231626000307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1231626000308 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1231626000309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1231626000310 DNA binding residues [nucleotide binding] 1231626000311 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1231626000312 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1231626000313 RNase E interface [polypeptide binding]; other site 1231626000314 trimer interface [polypeptide binding]; other site 1231626000315 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1231626000316 RNase E interface [polypeptide binding]; other site 1231626000317 trimer interface [polypeptide binding]; other site 1231626000318 active site 1231626000319 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1231626000320 putative nucleic acid binding region [nucleotide binding]; other site 1231626000321 G-X-X-G motif; other site 1231626000322 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1231626000323 RNA binding site [nucleotide binding]; other site 1231626000324 domain interface; other site 1231626000325 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1231626000326 16S/18S rRNA binding site [nucleotide binding]; other site 1231626000327 S13e-L30e interaction site [polypeptide binding]; other site 1231626000328 25S rRNA binding site [nucleotide binding]; other site 1231626000329 signal recognition particle protein; Provisional; Region: PRK10867 1231626000330 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1231626000331 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1231626000332 P loop; other site 1231626000333 GTP binding site [chemical binding]; other site 1231626000334 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1231626000335 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1231626000336 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1231626000337 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1231626000338 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1231626000339 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1231626000340 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1231626000341 HD domain; Region: HD_4; pfam13328 1231626000342 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1231626000343 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1231626000344 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1231626000345 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1231626000346 alphaNTD homodimer interface [polypeptide binding]; other site 1231626000347 alphaNTD - beta interaction site [polypeptide binding]; other site 1231626000348 alphaNTD - beta' interaction site [polypeptide binding]; other site 1231626000349 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1231626000350 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1231626000351 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1231626000352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1231626000353 RNA binding surface [nucleotide binding]; other site 1231626000354 30S ribosomal protein S11; Validated; Region: PRK05309 1231626000355 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1231626000356 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1231626000357 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1231626000358 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1231626000359 rRNA binding site [nucleotide binding]; other site 1231626000360 predicted 30S ribosome binding site; other site 1231626000361 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1231626000362 SecY translocase; Region: SecY; pfam00344 1231626000363 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1231626000364 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1231626000365 23S rRNA binding site [nucleotide binding]; other site 1231626000366 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1231626000367 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1231626000368 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1231626000369 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1231626000370 23S rRNA interface [nucleotide binding]; other site 1231626000371 L21e interface [polypeptide binding]; other site 1231626000372 5S rRNA interface [nucleotide binding]; other site 1231626000373 L27 interface [polypeptide binding]; other site 1231626000374 L5 interface [polypeptide binding]; other site 1231626000375 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1231626000376 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1231626000377 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1231626000378 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1231626000379 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1231626000380 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1231626000381 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1231626000382 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1231626000383 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1231626000384 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1231626000385 RNA binding site [nucleotide binding]; other site 1231626000386 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1231626000387 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1231626000388 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1231626000389 putative translocon interaction site; other site 1231626000390 23S rRNA interface [nucleotide binding]; other site 1231626000391 signal recognition particle (SRP54) interaction site; other site 1231626000392 L23 interface [polypeptide binding]; other site 1231626000393 trigger factor interaction site; other site 1231626000394 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1231626000395 23S rRNA interface [nucleotide binding]; other site 1231626000396 5S rRNA interface [nucleotide binding]; other site 1231626000397 putative antibiotic binding site [chemical binding]; other site 1231626000398 L25 interface [polypeptide binding]; other site 1231626000399 L27 interface [polypeptide binding]; other site 1231626000400 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1231626000401 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1231626000402 G-X-X-G motif; other site 1231626000403 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1231626000404 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1231626000405 putative translocon binding site; other site 1231626000406 protein-rRNA interface [nucleotide binding]; other site 1231626000407 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1231626000408 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1231626000409 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1231626000410 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1231626000411 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1231626000412 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1231626000413 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1231626000414 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 1231626000415 RimM N-terminal domain; Region: RimM; pfam01782 1231626000416 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1231626000417 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1231626000418 nucleotide binding site [chemical binding]; other site 1231626000419 SulA interaction site; other site 1231626000420 cell division protein FtsA; Region: ftsA; TIGR01174 1231626000421 Cell division protein FtsA; Region: FtsA; smart00842 1231626000422 Cell division protein FtsA; Region: FtsA; pfam14450 1231626000423 TLC ATP/ADP transporter; Region: TLC; cl03940 1231626000424 TLC ATP/ADP transporter; Region: TLC; cl03940 1231626000425 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1231626000426 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1231626000427 dimer interface [polypeptide binding]; other site 1231626000428 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1231626000429 catalytic triad [active] 1231626000430 peroxidatic and resolving cysteines [active] 1231626000431 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 1231626000432 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1231626000433 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1231626000434 ABC-ATPase subunit interface; other site 1231626000435 dimer interface [polypeptide binding]; other site 1231626000436 putative PBP binding regions; other site 1231626000437 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1231626000438 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1231626000439 dimer interface [polypeptide binding]; other site 1231626000440 motif 1; other site 1231626000441 active site 1231626000442 motif 2; other site 1231626000443 motif 3; other site 1231626000444 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1231626000445 anticodon binding site; other site 1231626000446 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1231626000447 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1231626000448 active site 1231626000449 homodimer interface [polypeptide binding]; other site 1231626000450 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1231626000451 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1231626000452 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1231626000453 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1231626000454 protein binding site [polypeptide binding]; other site 1231626000455 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1231626000456 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1231626000457 active site 1231626000458 HIGH motif; other site 1231626000459 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1231626000460 KMSKS motif; other site 1231626000461 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1231626000462 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1231626000463 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1231626000464 E3 interaction surface; other site 1231626000465 lipoyl attachment site [posttranslational modification]; other site 1231626000466 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1231626000467 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1231626000468 MgtE intracellular N domain; Region: MgtE_N; smart00924 1231626000469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1231626000470 Divalent cation transporter; Region: MgtE; cl00786 1231626000471 Haemolytic domain; Region: Haemolytic; pfam01809 1231626000472 GTPase Era; Reviewed; Region: era; PRK00089 1231626000473 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1231626000474 G1 box; other site 1231626000475 GTP/Mg2+ binding site [chemical binding]; other site 1231626000476 Switch I region; other site 1231626000477 G2 box; other site 1231626000478 Switch II region; other site 1231626000479 G3 box; other site 1231626000480 G4 box; other site 1231626000481 G5 box; other site 1231626000482 KH domain; Region: KH_2; pfam07650 1231626000483 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1231626000484 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1231626000485 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1231626000486 DNA primase; Validated; Region: dnaG; PRK05667 1231626000487 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1231626000488 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1231626000489 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1231626000490 active site 1231626000491 metal binding site [ion binding]; metal-binding site 1231626000492 interdomain interaction site; other site 1231626000493 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1231626000494 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1231626000495 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1231626000496 putative active site [active] 1231626000497 catalytic triad [active] 1231626000498 putative dimer interface [polypeptide binding]; other site 1231626000499 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626000500 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626000501 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1231626000502 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1231626000503 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1231626000504 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1231626000505 alpha subunit interaction interface [polypeptide binding]; other site 1231626000506 Walker A motif; other site 1231626000507 ATP binding site [chemical binding]; other site 1231626000508 Walker B motif; other site 1231626000509 inhibitor binding site; inhibition site 1231626000510 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1231626000511 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1231626000512 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1231626000513 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1231626000514 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1231626000515 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1231626000516 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1231626000517 active site 1231626000518 DNA binding site [nucleotide binding] 1231626000519 Int/Topo IB signature motif; other site 1231626000520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1231626000521 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1231626000522 FtsX-like permease family; Region: FtsX; pfam02687 1231626000523 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1231626000524 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1231626000525 FtsX-like permease family; Region: FtsX; pfam02687 1231626000526 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1231626000527 HlyD family secretion protein; Region: HlyD_3; pfam13437 1231626000528 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1231626000529 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1231626000530 Walker A/P-loop; other site 1231626000531 ATP binding site [chemical binding]; other site 1231626000532 Q-loop/lid; other site 1231626000533 ABC transporter signature motif; other site 1231626000534 Walker B; other site 1231626000535 D-loop; other site 1231626000536 H-loop/switch region; other site 1231626000537 Outer membrane efflux protein; Region: OEP; pfam02321 1231626000538 Outer membrane efflux protein; Region: OEP; pfam02321 1231626000539 Predicted permeases [General function prediction only]; Region: COG0795 1231626000540 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1231626000541 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1231626000542 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1231626000543 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1231626000544 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1231626000545 Walker A/P-loop; other site 1231626000546 ATP binding site [chemical binding]; other site 1231626000547 Q-loop/lid; other site 1231626000548 ABC transporter signature motif; other site 1231626000549 Walker B; other site 1231626000550 D-loop; other site 1231626000551 H-loop/switch region; other site 1231626000552 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1231626000553 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1231626000554 GatB domain; Region: GatB_Yqey; smart00845 1231626000555 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000556 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000557 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626000558 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000559 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000560 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626000561 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626000562 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1231626000563 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1231626000564 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1231626000565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626000566 active site 1231626000567 HIGH motif; other site 1231626000568 nucleotide binding site [chemical binding]; other site 1231626000569 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1231626000570 KMSK motif region; other site 1231626000571 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1231626000572 tRNA binding surface [nucleotide binding]; other site 1231626000573 anticodon binding site; other site 1231626000574 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1231626000575 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1231626000576 putative trimer interface [polypeptide binding]; other site 1231626000577 putative CoA binding site [chemical binding]; other site 1231626000578 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 1231626000579 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1231626000580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1231626000581 ABC-ATPase subunit interface; other site 1231626000582 dimer interface [polypeptide binding]; other site 1231626000583 putative PBP binding regions; other site 1231626000584 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1231626000585 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1231626000586 TMP-binding site; other site 1231626000587 ATP-binding site [chemical binding]; other site 1231626000588 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1231626000589 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1231626000590 catalytic residue [active] 1231626000591 putative FPP diphosphate binding site; other site 1231626000592 putative FPP binding hydrophobic cleft; other site 1231626000593 dimer interface [polypeptide binding]; other site 1231626000594 putative IPP diphosphate binding site; other site 1231626000595 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1231626000596 Peptidase family M28; Region: Peptidase_M28; pfam04389 1231626000597 metal binding site [ion binding]; metal-binding site 1231626000598 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1231626000599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1231626000600 ATP binding site [chemical binding]; other site 1231626000601 Mg2+ binding site [ion binding]; other site 1231626000602 G-X-G motif; other site 1231626000603 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 1231626000604 ATP binding site [chemical binding]; other site 1231626000605 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1231626000606 active site 1231626000607 putative metal-binding site [ion binding]; other site 1231626000608 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1231626000609 Family of unknown function (DUF490); Region: DUF490; pfam04357 1231626000610 Family of unknown function (DUF490); Region: DUF490; pfam04357 1231626000611 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1231626000612 G1 box; other site 1231626000613 GTP/Mg2+ binding site [chemical binding]; other site 1231626000614 Switch I region; other site 1231626000615 G2 box; other site 1231626000616 G3 box; other site 1231626000617 Switch II region; other site 1231626000618 G4 box; other site 1231626000619 G5 box; other site 1231626000620 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1231626000621 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1231626000622 homodimer interface [polypeptide binding]; other site 1231626000623 substrate-cofactor binding pocket; other site 1231626000624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1231626000625 catalytic residue [active] 1231626000626 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1231626000627 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1231626000628 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1231626000629 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1231626000630 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1231626000631 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1231626000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1231626000633 Walker A motif; other site 1231626000634 ATP binding site [chemical binding]; other site 1231626000635 Walker B motif; other site 1231626000636 arginine finger; other site 1231626000637 lipoprotein signal peptidase; Provisional; Region: PRK14787 1231626000638 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1231626000639 lipoprotein signal peptidase; Provisional; Region: PRK14787 1231626000640 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1231626000641 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1231626000642 ribonuclease P; Reviewed; Region: rnpA; PRK01903 1231626000643 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626000644 Na binding site [ion binding]; other site 1231626000645 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1231626000646 HD domain; Region: HD_4; pfam13328 1231626000647 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1231626000648 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1231626000649 NAD(P) binding site [chemical binding]; other site 1231626000650 homotetramer interface [polypeptide binding]; other site 1231626000651 homodimer interface [polypeptide binding]; other site 1231626000652 active site 1231626000653 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1231626000654 active site 1231626000655 dimerization interface [polypeptide binding]; other site 1231626000656 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1231626000657 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1231626000658 rhodanese superfamily protein; Provisional; Region: PRK05320 1231626000659 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1231626000660 active site residue [active] 1231626000661 DNA protecting protein DprA; Region: dprA; TIGR00732 1231626000662 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1231626000663 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626000664 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626000665 Na binding site [ion binding]; other site 1231626000666 DNA photolyase; Region: DNA_photolyase; pfam00875 1231626000667 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1231626000668 DNA gyrase subunit A; Validated; Region: PRK05560 1231626000669 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1231626000670 CAP-like domain; other site 1231626000671 active site 1231626000672 primary dimer interface [polypeptide binding]; other site 1231626000673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1231626000674 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1231626000675 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1231626000676 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1231626000677 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1231626000678 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1231626000679 Dimer interface [polypeptide binding]; other site 1231626000680 anticodon binding site; other site 1231626000681 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1231626000682 homodimer interface [polypeptide binding]; other site 1231626000683 motif 1; other site 1231626000684 motif 2; other site 1231626000685 active site 1231626000686 motif 3; other site 1231626000687 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1231626000688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1231626000689 Walker A/P-loop; other site 1231626000690 ATP binding site [chemical binding]; other site 1231626000691 Q-loop/lid; other site 1231626000692 ABC transporter signature motif; other site 1231626000693 Walker B; other site 1231626000694 D-loop; other site 1231626000695 H-loop/switch region; other site 1231626000696 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1231626000697 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1231626000698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1231626000699 Walker A/P-loop; other site 1231626000700 ATP binding site [chemical binding]; other site 1231626000701 Q-loop/lid; other site 1231626000702 ABC transporter signature motif; other site 1231626000703 Walker B; other site 1231626000704 D-loop; other site 1231626000705 H-loop/switch region; other site 1231626000706 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1231626000707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1231626000708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1231626000709 dimer interface [polypeptide binding]; other site 1231626000710 conserved gate region; other site 1231626000711 putative PBP binding loops; other site 1231626000712 ABC-ATPase subunit interface; other site 1231626000713 Ctf8; Region: Ctf8; pfam09696 1231626000714 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1231626000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1231626000716 dimer interface [polypeptide binding]; other site 1231626000717 conserved gate region; other site 1231626000718 putative PBP binding loops; other site 1231626000719 ABC-ATPase subunit interface; other site 1231626000720 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1231626000721 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1231626000722 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1231626000723 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1231626000724 active site 1231626000725 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 1231626000726 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1231626000727 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1231626000728 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1231626000729 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1231626000730 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1231626000731 trimer interface [polypeptide binding]; other site 1231626000732 active site 1231626000733 UDP-GlcNAc binding site [chemical binding]; other site 1231626000734 lipid binding site [chemical binding]; lipid-binding site 1231626000735 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1231626000736 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1231626000737 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1231626000738 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1231626000739 active site 1231626000740 dimer interface [polypeptide binding]; other site 1231626000741 motif 1; other site 1231626000742 motif 2; other site 1231626000743 motif 3; other site 1231626000744 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1231626000745 anticodon binding site; other site 1231626000746 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1231626000747 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 1231626000748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1231626000749 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1231626000750 active site 1231626000751 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1231626000752 dimer interface [polypeptide binding]; other site 1231626000753 substrate binding site [chemical binding]; other site 1231626000754 catalytic residues [active] 1231626000755 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1231626000756 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1231626000757 ring oligomerisation interface [polypeptide binding]; other site 1231626000758 ATP/Mg binding site [chemical binding]; other site 1231626000759 stacking interactions; other site 1231626000760 hinge regions; other site 1231626000761 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1231626000762 oligomerisation interface [polypeptide binding]; other site 1231626000763 mobile loop; other site 1231626000764 roof hairpin; other site 1231626000765 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1231626000766 tetramer interface [polypeptide binding]; other site 1231626000767 TPP-binding site [chemical binding]; other site 1231626000768 heterodimer interface [polypeptide binding]; other site 1231626000769 phosphorylation loop region [posttranslational modification] 1231626000770 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1231626000771 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1231626000772 PYR/PP interface [polypeptide binding]; other site 1231626000773 dimer interface [polypeptide binding]; other site 1231626000774 TPP binding site [chemical binding]; other site 1231626000775 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1231626000776 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1231626000777 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1231626000778 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1231626000779 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1231626000780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626000781 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000782 Integrase core domain; Region: rve; pfam00665 1231626000783 AAA domain; Region: AAA_33; pfam13671 1231626000784 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1231626000785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626000786 Walker A/P-loop; other site 1231626000787 ATP binding site [chemical binding]; other site 1231626000788 Q-loop/lid; other site 1231626000789 ABC transporter signature motif; other site 1231626000790 Walker B; other site 1231626000791 D-loop; other site 1231626000792 H-loop/switch region; other site 1231626000793 DNA topoisomerase I; Provisional; Region: PRK08780 1231626000794 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1231626000795 active site 1231626000796 interdomain interaction site; other site 1231626000797 putative metal-binding site [ion binding]; other site 1231626000798 nucleotide binding site [chemical binding]; other site 1231626000799 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1231626000800 domain I; other site 1231626000801 DNA binding groove [nucleotide binding] 1231626000802 phosphate binding site [ion binding]; other site 1231626000803 domain II; other site 1231626000804 domain III; other site 1231626000805 nucleotide binding site [chemical binding]; other site 1231626000806 catalytic site [active] 1231626000807 domain IV; other site 1231626000808 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1231626000809 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1231626000810 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1231626000811 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1231626000812 Surface antigen; Region: Bac_surface_Ag; pfam01103 1231626000813 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1231626000814 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1231626000815 hypothetical protein; Reviewed; Region: PRK12497 1231626000816 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1231626000817 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1231626000818 Peptidase family M23; Region: Peptidase_M23; pfam01551 1231626000819 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1231626000820 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1231626000821 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1231626000822 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1231626000823 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1231626000824 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1231626000825 hypothetical protein; Provisional; Region: PRK05170 1231626000826 adenylate kinase; Reviewed; Region: adk; PRK00279 1231626000827 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1231626000828 AMP-binding site [chemical binding]; other site 1231626000829 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1231626000830 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1231626000831 GTP1/OBG; Region: GTP1_OBG; pfam01018 1231626000832 Obg GTPase; Region: Obg; cd01898 1231626000833 G1 box; other site 1231626000834 GTP/Mg2+ binding site [chemical binding]; other site 1231626000835 Switch I region; other site 1231626000836 G2 box; other site 1231626000837 G3 box; other site 1231626000838 Switch II region; other site 1231626000839 G4 box; other site 1231626000840 G5 box; other site 1231626000841 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1231626000842 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1231626000843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626000844 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626000845 Integrase core domain; Region: rve; pfam00665 1231626000846 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1231626000847 nucleophile elbow; other site 1231626000848 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1231626000849 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1231626000850 amidase catalytic site [active] 1231626000851 Zn binding residues [ion binding]; other site 1231626000852 substrate binding site [chemical binding]; other site 1231626000853 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1231626000854 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626000855 Virulence-associated protein E; Region: VirE; pfam05272 1231626000856 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1231626000857 active site 1231626000858 interdomain interaction site; other site 1231626000859 metal binding site [ion binding]; metal-binding site 1231626000860 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1231626000861 nucleotide binding site/active site [active] 1231626000862 HIT family signature motif; other site 1231626000863 catalytic residue [active] 1231626000864 antiporter inner membrane protein; Provisional; Region: PRK11670 1231626000865 Domain of unknown function DUF59; Region: DUF59; pfam01883 1231626000866 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1231626000867 Walker A motif; other site 1231626000868 ribonuclease Z; Region: RNase_Z; TIGR02651 1231626000869 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1231626000870 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1231626000871 RF-1 domain; Region: RF-1; pfam00472 1231626000872 OstA-like protein; Region: OstA_2; pfam13100 1231626000873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1231626000874 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1231626000875 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1231626000876 5S rRNA interface [nucleotide binding]; other site 1231626000877 CTC domain interface [polypeptide binding]; other site 1231626000878 L16 interface [polypeptide binding]; other site 1231626000879 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1231626000880 putative active site [active] 1231626000881 catalytic residue [active] 1231626000882 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1231626000883 IHF dimer interface [polypeptide binding]; other site 1231626000884 IHF - DNA interface [nucleotide binding]; other site 1231626000885 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 1231626000886 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1231626000887 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1231626000888 Walker A/P-loop; other site 1231626000889 ATP binding site [chemical binding]; other site 1231626000890 Q-loop/lid; other site 1231626000891 ABC transporter signature motif; other site 1231626000892 Walker B; other site 1231626000893 D-loop; other site 1231626000894 H-loop/switch region; other site 1231626000895 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1231626000896 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1231626000897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1231626000898 TPR motif; other site 1231626000899 binding surface 1231626000900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1231626000901 binding surface 1231626000902 TPR motif; other site 1231626000903 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1231626000904 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1231626000905 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1231626000906 ParB-like nuclease domain; Region: ParBc; pfam02195 1231626000907 KorB domain; Region: KorB; pfam08535 1231626000908 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1231626000909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1231626000910 P-loop; other site 1231626000911 Magnesium ion binding site [ion binding]; other site 1231626000912 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1231626000913 Magnesium ion binding site [ion binding]; other site 1231626000914 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1231626000915 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1231626000916 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1231626000917 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1231626000918 active site 1231626000919 multimer interface [polypeptide binding]; other site 1231626000920 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1231626000921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1231626000922 non-specific DNA binding site [nucleotide binding]; other site 1231626000923 salt bridge; other site 1231626000924 sequence-specific DNA binding site [nucleotide binding]; other site 1231626000925 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1231626000926 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1231626000927 S-adenosylmethionine binding site [chemical binding]; other site 1231626000928 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1231626000929 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1231626000930 dimerization interface [polypeptide binding]; other site 1231626000931 active site 1231626000932 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1231626000933 dimer interface [polypeptide binding]; other site 1231626000934 catalytic triad [active] 1231626000935 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1231626000936 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1231626000937 active site 1231626000938 DNA binding site [nucleotide binding] 1231626000939 Int/Topo IB signature motif; other site 1231626000940 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1231626000941 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1231626000942 putative acyl-acceptor binding pocket; other site 1231626000943 GrpE; Region: GrpE; pfam01025 1231626000944 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1231626000945 dimer interface [polypeptide binding]; other site 1231626000946 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1231626000947 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1231626000948 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1231626000949 HSP70 interaction site [polypeptide binding]; other site 1231626000950 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1231626000951 substrate binding site [polypeptide binding]; other site 1231626000952 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1231626000953 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1231626000954 dimer interface [polypeptide binding]; other site 1231626000955 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 1231626000956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626000957 Walker A motif; other site 1231626000958 ATP binding site [chemical binding]; other site 1231626000959 Walker B motif; other site 1231626000960 arginine finger; other site 1231626000961 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1231626000962 elongation factor Tu; Reviewed; Region: PRK12735 1231626000963 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1231626000964 G1 box; other site 1231626000965 GEF interaction site [polypeptide binding]; other site 1231626000966 GTP/Mg2+ binding site [chemical binding]; other site 1231626000967 Switch I region; other site 1231626000968 G2 box; other site 1231626000969 G3 box; other site 1231626000970 Switch II region; other site 1231626000971 G4 box; other site 1231626000972 G5 box; other site 1231626000973 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1231626000974 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1231626000975 Antibiotic Binding Site [chemical binding]; other site 1231626000976 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1231626000977 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1231626000978 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1231626000979 putative homodimer interface [polypeptide binding]; other site 1231626000980 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1231626000981 heterodimer interface [polypeptide binding]; other site 1231626000982 homodimer interface [polypeptide binding]; other site 1231626000983 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1231626000984 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1231626000985 23S rRNA interface [nucleotide binding]; other site 1231626000986 L7/L12 interface [polypeptide binding]; other site 1231626000987 putative thiostrepton binding site; other site 1231626000988 L25 interface [polypeptide binding]; other site 1231626000989 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1231626000990 mRNA/rRNA interface [nucleotide binding]; other site 1231626000991 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1231626000992 23S rRNA interface [nucleotide binding]; other site 1231626000993 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1231626000994 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1231626000995 core dimer interface [polypeptide binding]; other site 1231626000996 peripheral dimer interface [polypeptide binding]; other site 1231626000997 L10 interface [polypeptide binding]; other site 1231626000998 L11 interface [polypeptide binding]; other site 1231626000999 putative EF-Tu interaction site [polypeptide binding]; other site 1231626001000 putative EF-G interaction site [polypeptide binding]; other site 1231626001001 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 1231626001002 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1231626001003 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1231626001004 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1231626001005 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1231626001006 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1231626001007 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1231626001008 RPB3 interaction site [polypeptide binding]; other site 1231626001009 RPB1 interaction site [polypeptide binding]; other site 1231626001010 RPB11 interaction site [polypeptide binding]; other site 1231626001011 RPB10 interaction site [polypeptide binding]; other site 1231626001012 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1231626001013 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1231626001014 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1231626001015 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1231626001016 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1231626001017 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1231626001018 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1231626001019 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1231626001020 DNA binding site [nucleotide binding] 1231626001021 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1231626001022 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1231626001023 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1231626001024 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001025 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1231626001027 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1231626001028 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1231626001029 ssDNA binding site; other site 1231626001030 generic binding surface II; other site 1231626001031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1231626001032 ATP binding site [chemical binding]; other site 1231626001033 putative Mg++ binding site [ion binding]; other site 1231626001034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1231626001035 nucleotide binding region [chemical binding]; other site 1231626001036 ATP-binding site [chemical binding]; other site 1231626001037 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1231626001038 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1231626001039 active site 1231626001040 Zn binding site [ion binding]; other site 1231626001041 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1231626001042 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1231626001043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1231626001044 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1231626001045 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1231626001046 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1231626001047 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1231626001048 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1231626001049 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626001050 Na binding site [ion binding]; other site 1231626001051 HD domain; Region: HD_4; pfam13328 1231626001052 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626001053 Na binding site [ion binding]; other site 1231626001054 HD domain; Region: HD_4; pfam13328 1231626001055 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1231626001056 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1231626001057 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1231626001058 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1231626001059 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1231626001060 HIGH motif; other site 1231626001061 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1231626001062 active site 1231626001063 KMSKS motif; other site 1231626001064 hypothetical protein; Provisional; Region: PRK13665 1231626001065 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1231626001066 dimer interface [polypeptide binding]; other site 1231626001067 putative radical transfer pathway; other site 1231626001068 diiron center [ion binding]; other site 1231626001069 tyrosyl radical; other site 1231626001070 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 1231626001071 ATP cone domain; Region: ATP-cone; pfam03477 1231626001072 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1231626001073 active site 1231626001074 dimer interface [polypeptide binding]; other site 1231626001075 catalytic residues [active] 1231626001076 effector binding site; other site 1231626001077 R2 peptide binding site; other site 1231626001078 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1231626001079 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1231626001080 Mg++ binding site [ion binding]; other site 1231626001081 putative catalytic motif [active] 1231626001082 putative substrate binding site [chemical binding]; other site 1231626001083 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1231626001084 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1231626001085 acyl-activating enzyme (AAE) consensus motif; other site 1231626001086 putative AMP binding site [chemical binding]; other site 1231626001087 putative active site [active] 1231626001088 putative CoA binding site [chemical binding]; other site 1231626001089 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1231626001090 SmpB-tmRNA interface; other site 1231626001091 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1231626001092 RNA/DNA hybrid binding site [nucleotide binding]; other site 1231626001093 active site 1231626001094 Bacterial Ig-like domain; Region: Big_5; pfam13205 1231626001095 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1231626001096 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1231626001097 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1231626001098 motif 1; other site 1231626001099 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1231626001100 active site 1231626001101 motif 2; other site 1231626001102 motif 3; other site 1231626001103 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1231626001104 anticodon binding site; other site 1231626001105 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1231626001106 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1231626001107 putative active site [active] 1231626001108 putative metal binding site [ion binding]; other site 1231626001109 rod shape-determining protein MreB; Provisional; Region: PRK13927 1231626001110 MreB and similar proteins; Region: MreB_like; cd10225 1231626001111 nucleotide binding site [chemical binding]; other site 1231626001112 Mg binding site [ion binding]; other site 1231626001113 putative protofilament interaction site [polypeptide binding]; other site 1231626001114 RodZ interaction site [polypeptide binding]; other site 1231626001115 Transposase; Region: HTH_Tnp_1; cl17663 1231626001116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626001117 HTH-like domain; Region: HTH_21; pfam13276 1231626001118 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001119 Integrase core domain; Region: rve; pfam00665 1231626001120 Integrase core domain; Region: rve_3; pfam13683 1231626001121 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 1231626001122 active site 1231626001123 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1231626001124 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1231626001125 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1231626001126 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1231626001127 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1231626001128 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1231626001129 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1231626001130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1231626001131 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1231626001132 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1231626001133 active site 1231626001134 multimer interface [polypeptide binding]; other site 1231626001135 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1231626001136 conserved cys residue [active] 1231626001137 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1231626001138 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1231626001139 active site 1231626001140 HIGH motif; other site 1231626001141 dimer interface [polypeptide binding]; other site 1231626001142 KMSKS motif; other site 1231626001143 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1231626001144 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1231626001145 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 1231626001146 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1231626001147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1231626001148 nucleotide binding region [chemical binding]; other site 1231626001149 ATP-binding site [chemical binding]; other site 1231626001150 recombinase A; Provisional; Region: recA; PRK09354 1231626001151 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1231626001152 hexamer interface [polypeptide binding]; other site 1231626001153 Walker A motif; other site 1231626001154 ATP binding site [chemical binding]; other site 1231626001155 Walker B motif; other site 1231626001156 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1231626001157 Surface antigen; Region: Bac_surface_Ag; pfam01103 1231626001158 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1231626001159 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1231626001160 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1231626001161 homodimer interface [polypeptide binding]; other site 1231626001162 oligonucleotide binding site [chemical binding]; other site 1231626001163 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1231626001164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 1231626001165 Colicin V production protein; Region: Colicin_V; pfam02674 1231626001166 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1231626001167 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1231626001168 G1 box; other site 1231626001169 putative GEF interaction site [polypeptide binding]; other site 1231626001170 GTP/Mg2+ binding site [chemical binding]; other site 1231626001171 Switch I region; other site 1231626001172 G2 box; other site 1231626001173 G3 box; other site 1231626001174 Switch II region; other site 1231626001175 G4 box; other site 1231626001176 G5 box; other site 1231626001177 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1231626001178 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1231626001179 hypothetical protein; Reviewed; Region: PRK00024 1231626001180 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1231626001181 MPN+ (JAMM) motif; other site 1231626001182 Zinc-binding site [ion binding]; other site 1231626001183 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1231626001184 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001185 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626001186 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001187 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001188 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001189 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1231626001190 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001191 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001192 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 1231626001193 Zn binding site [ion binding]; other site 1231626001194 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 1231626001195 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1231626001196 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1231626001197 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1231626001198 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1231626001199 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1231626001200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1231626001201 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1231626001202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626001203 Walker A motif; other site 1231626001204 ATP binding site [chemical binding]; other site 1231626001205 Walker B motif; other site 1231626001206 arginine finger; other site 1231626001207 Peptidase family M41; Region: Peptidase_M41; pfam01434 1231626001208 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1231626001209 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1231626001210 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1231626001211 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1231626001212 nucleoside/Zn binding site; other site 1231626001213 dimer interface [polypeptide binding]; other site 1231626001214 catalytic motif [active] 1231626001215 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1231626001216 catalytic motif [active] 1231626001217 Zn binding site [ion binding]; other site 1231626001218 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1231626001219 ribosomal protein L33; Region: rpl33; CHL00104 1231626001220 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 1231626001221 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1231626001222 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1231626001223 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1231626001224 Ribosomal L32p protein family; Region: Ribosomal_L32p; pfam01783 1231626001225 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1231626001226 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1231626001227 dimer interface [polypeptide binding]; other site 1231626001228 active site 1231626001229 CoA binding pocket [chemical binding]; other site 1231626001230 elongation factor P; Validated; Region: PRK00529 1231626001231 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1231626001232 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1231626001233 RNA binding site [nucleotide binding]; other site 1231626001234 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1231626001235 RNA binding site [nucleotide binding]; other site 1231626001236 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1231626001237 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1231626001238 carboxyltransferase (CT) interaction site; other site 1231626001239 biotinylation site [posttranslational modification]; other site 1231626001240 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1231626001241 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1231626001242 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1231626001243 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1231626001244 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626001245 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1231626001246 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1231626001247 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1231626001248 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1231626001249 acyl carrier protein; Provisional; Region: acpP; PRK00982 1231626001250 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1231626001251 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1231626001252 dimer interface [polypeptide binding]; other site 1231626001253 active site 1231626001254 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1231626001255 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1231626001256 dimerization interface [polypeptide binding]; other site 1231626001257 active site 1231626001258 metal binding site [ion binding]; metal-binding site 1231626001259 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1231626001260 dsRNA binding site [nucleotide binding]; other site 1231626001261 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1231626001262 putative ABC transporter; Region: ycf24; CHL00085 1231626001263 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626001264 Na binding site [ion binding]; other site 1231626001265 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1231626001266 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1231626001267 FAD binding pocket [chemical binding]; other site 1231626001268 FAD binding motif [chemical binding]; other site 1231626001269 phosphate binding motif [ion binding]; other site 1231626001270 beta-alpha-beta structure motif; other site 1231626001271 NAD binding pocket [chemical binding]; other site 1231626001272 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1231626001273 Peptidase family M50; Region: Peptidase_M50; pfam02163 1231626001274 active site 1231626001275 putative substrate binding region [chemical binding]; other site 1231626001276 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001277 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001278 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001279 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1231626001280 MutS domain I; Region: MutS_I; pfam01624 1231626001281 MutS domain II; Region: MutS_II; pfam05188 1231626001282 MutS domain III; Region: MutS_III; pfam05192 1231626001283 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1231626001284 Walker A/P-loop; other site 1231626001285 ATP binding site [chemical binding]; other site 1231626001286 Q-loop/lid; other site 1231626001287 ABC transporter signature motif; other site 1231626001288 Walker B; other site 1231626001289 D-loop; other site 1231626001290 H-loop/switch region; other site 1231626001291 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1231626001292 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1231626001293 active site 1231626001294 metal binding site [ion binding]; metal-binding site 1231626001295 homotetramer interface [polypeptide binding]; other site 1231626001296 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1231626001297 active site 1231626001298 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1231626001299 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1231626001300 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1231626001301 Protein export membrane protein; Region: SecD_SecF; cl14618 1231626001302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1231626001303 Predicted esterase [General function prediction only]; Region: COG0400 1231626001304 putative hydrolase; Provisional; Region: PRK11460 1231626001305 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1231626001306 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1231626001307 minor groove reading motif; other site 1231626001308 helix-hairpin-helix signature motif; other site 1231626001309 substrate binding pocket [chemical binding]; other site 1231626001310 active site 1231626001311 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1231626001312 GTP-binding protein LepA; Provisional; Region: PRK05433 1231626001313 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1231626001314 G1 box; other site 1231626001315 putative GEF interaction site [polypeptide binding]; other site 1231626001316 GTP/Mg2+ binding site [chemical binding]; other site 1231626001317 Switch I region; other site 1231626001318 G2 box; other site 1231626001319 G3 box; other site 1231626001320 Switch II region; other site 1231626001321 G4 box; other site 1231626001322 G5 box; other site 1231626001323 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1231626001324 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1231626001325 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1231626001326 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1231626001327 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1231626001328 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1231626001329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1231626001330 binding surface 1231626001331 TPR motif; other site 1231626001332 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1231626001333 DHH family; Region: DHH; pfam01368 1231626001334 DHHA1 domain; Region: DHHA1; pfam02272 1231626001335 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1231626001336 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1231626001337 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1231626001338 tetramer interface [polypeptide binding]; other site 1231626001339 TPP-binding site [chemical binding]; other site 1231626001340 heterodimer interface [polypeptide binding]; other site 1231626001341 phosphorylation loop region [posttranslational modification] 1231626001342 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1231626001343 gamma subunit interface [polypeptide binding]; other site 1231626001344 LBP interface [polypeptide binding]; other site 1231626001345 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1231626001346 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1231626001347 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1231626001348 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1231626001349 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1231626001350 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1231626001351 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1231626001352 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1231626001353 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1231626001354 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1231626001355 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1231626001356 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1231626001357 putative DNA binding site [nucleotide binding]; other site 1231626001358 putative Zn2+ binding site [ion binding]; other site 1231626001359 AsnC family; Region: AsnC_trans_reg; pfam01037 1231626001360 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1231626001361 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1231626001362 PGAP1-like protein; Region: PGAP1; pfam07819 1231626001363 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1231626001364 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1231626001365 active site 1231626001366 Zn binding site [ion binding]; other site 1231626001367 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626001368 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626001369 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1231626001370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1231626001371 active site 1231626001372 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1231626001373 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1231626001374 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1231626001375 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1231626001376 23S rRNA interface [nucleotide binding]; other site 1231626001377 L3 interface [polypeptide binding]; other site 1231626001378 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1231626001379 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1231626001380 rRNA interaction site [nucleotide binding]; other site 1231626001381 S8 interaction site; other site 1231626001382 putative laminin-1 binding site; other site 1231626001383 elongation factor Ts; Provisional; Region: tsf; PRK09377 1231626001384 UBA/TS-N domain; Region: UBA; pfam00627 1231626001385 Elongation factor TS; Region: EF_TS; pfam00889 1231626001386 Elongation factor TS; Region: EF_TS; pfam00889 1231626001387 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1231626001388 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1231626001389 Ligand Binding Site [chemical binding]; other site 1231626001390 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1231626001391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1231626001392 ATP binding site [chemical binding]; other site 1231626001393 putative Mg++ binding site [ion binding]; other site 1231626001394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1231626001395 nucleotide binding region [chemical binding]; other site 1231626001396 ATP-binding site [chemical binding]; other site 1231626001397 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1231626001398 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1231626001399 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1231626001400 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1231626001401 trimer interface [polypeptide binding]; other site 1231626001402 active site 1231626001403 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1231626001404 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1231626001405 FMN binding site [chemical binding]; other site 1231626001406 active site 1231626001407 catalytic residues [active] 1231626001408 substrate binding site [chemical binding]; other site 1231626001409 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1231626001410 tandem repeat interface [polypeptide binding]; other site 1231626001411 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1231626001412 oligomer interface [polypeptide binding]; other site 1231626001413 active site residues [active] 1231626001414 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1231626001415 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1231626001416 tandem repeat interface [polypeptide binding]; other site 1231626001417 oligomer interface [polypeptide binding]; other site 1231626001418 active site residues [active] 1231626001419 5'-3' exonuclease; Region: 53EXOc; smart00475 1231626001420 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1231626001421 active site 1231626001422 metal binding site 1 [ion binding]; metal-binding site 1231626001423 putative 5' ssDNA interaction site; other site 1231626001424 metal binding site 3; metal-binding site 1231626001425 metal binding site 2 [ion binding]; metal-binding site 1231626001426 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1231626001427 putative DNA binding site [nucleotide binding]; other site 1231626001428 putative metal binding site [ion binding]; other site 1231626001429 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001430 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001431 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 1231626001432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001433 active site 1231626001434 HIGH motif; other site 1231626001435 nucleotide binding site [chemical binding]; other site 1231626001436 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001437 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1231626001438 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001440 active site 1231626001441 KMSKS motif; other site 1231626001442 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1231626001443 tRNA binding surface [nucleotide binding]; other site 1231626001444 RDD family; Region: RDD; pfam06271 1231626001445 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001446 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626001447 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626001448 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1231626001449 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1231626001450 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1231626001451 dimer interface [polypeptide binding]; other site 1231626001452 motif 1; other site 1231626001453 active site 1231626001454 motif 2; other site 1231626001455 motif 3; other site 1231626001456 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626001457 Na binding site [ion binding]; other site 1231626001458 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1231626001459 FAD binding domain; Region: FAD_binding_4; pfam01565 1231626001460 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1231626001461 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001462 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001463 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626001464 Helix-turn-helix domain; Region: HTH_28; pfam13518 1231626001465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1231626001466 Integrase core domain; Region: rve; pfam00665 1231626001467 Integrase core domain; Region: rve_3; pfam13683 1231626001468 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1231626001469 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1231626001470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1231626001471 S-adenosylmethionine binding site [chemical binding]; other site 1231626001472 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1231626001473 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1231626001474 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1231626001475 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1231626001476 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1231626001477 Transglycosylase; Region: Transgly; pfam00912 1231626001478 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1231626001479 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1231626001480 ribonuclease R; Region: RNase_R; TIGR02063 1231626001481 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1231626001482 RNB domain; Region: RNB; pfam00773 1231626001483 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1231626001484 RNA binding site [nucleotide binding]; other site 1231626001485 seryl-tRNA synthetase; Provisional; Region: PRK05431 1231626001486 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1231626001487 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1231626001488 dimer interface [polypeptide binding]; other site 1231626001489 active site 1231626001490 motif 1; other site 1231626001491 motif 2; other site 1231626001492 motif 3; other site 1231626001493 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1231626001494 transcription termination factor Rho; Provisional; Region: PRK12608 1231626001495 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1231626001496 RNA binding site [nucleotide binding]; other site 1231626001497 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1231626001498 multimer interface [polypeptide binding]; other site 1231626001499 Walker A motif; other site 1231626001500 ATP binding site [chemical binding]; other site 1231626001501 Walker B motif; other site 1231626001502 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1231626001503 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1231626001504 active site 1231626001505 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1231626001506 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1231626001507 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1231626001508 Transposase domain (DUF772); Region: DUF772; pfam05598 1231626001509 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 1231626001510 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 1231626001511 Smr domain; Region: Smr; pfam01713 1231626001512 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1231626001513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1231626001514 ATP binding site [chemical binding]; other site 1231626001515 Mg2+ binding site [ion binding]; other site 1231626001516 G-X-G motif; other site 1231626001517 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1231626001518 anchoring element; other site 1231626001519 dimer interface [polypeptide binding]; other site 1231626001520 ATP binding site [chemical binding]; other site 1231626001521 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1231626001522 active site 1231626001523 putative metal-binding site [ion binding]; other site 1231626001524 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1231626001525 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1231626001526 Integrase core domain; Region: rve_3; cl15866 1231626001527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1231626001528 Integrase core domain; Region: rve; pfam00665 1231626001529 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626001530 Helix-turn-helix domain; Region: HTH_28; pfam13518 1231626001531 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1231626001532 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1231626001533 active site 1231626001534 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1231626001535 catalytic motif [active] 1231626001536 Zn binding site [ion binding]; other site 1231626001537 heat shock protein 90; Provisional; Region: PRK05218 1231626001538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1231626001539 ATP binding site [chemical binding]; other site 1231626001540 Mg2+ binding site [ion binding]; other site 1231626001541 G-X-G motif; other site 1231626001542 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626001544 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1231626001545 Clp amino terminal domain; Region: Clp_N; pfam02861 1231626001546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626001547 Walker A motif; other site 1231626001548 ATP binding site [chemical binding]; other site 1231626001549 Walker B motif; other site 1231626001550 arginine finger; other site 1231626001551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626001552 Walker A motif; other site 1231626001553 ATP binding site [chemical binding]; other site 1231626001554 Walker B motif; other site 1231626001555 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1231626001556 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1231626001557 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1231626001558 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1231626001559 putative transposase; Provisional; Region: PRK09857 1231626001560 Transposase; Region: HTH_Tnp_1; cl17663 1231626001561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626001562 HTH-like domain; Region: HTH_21; pfam13276 1231626001563 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001564 Integrase core domain; Region: rve; pfam00665 1231626001565 Integrase core domain; Region: rve_3; pfam13683 1231626001566 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1231626001567 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1231626001568 active site 1231626001569 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626001570 Na binding site [ion binding]; other site 1231626001571 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1231626001572 HD domain; Region: HD_4; pfam13328 1231626001573 Transposase; Region: HTH_Tnp_1; cl17663 1231626001574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626001575 HTH-like domain; Region: HTH_21; pfam13276 1231626001576 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001577 Integrase core domain; Region: rve; pfam00665 1231626001578 Integrase core domain; Region: rve_3; pfam13683 1231626001579 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001580 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001581 MULE transposase domain; Region: MULE; pfam10551 1231626001582 hypothetical protein; Reviewed; Region: PRK09588 1231626001583 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1231626001584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1231626001585 MULE transposase domain; Region: MULE; pfam10551 1231626001586 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626001587 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626001588 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1231626001589 active site 1231626001590 catalytic residues [active] 1231626001591 DNA binding site [nucleotide binding] 1231626001592 Int/Topo IB signature motif; other site 1231626001593 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626001594 Na binding site [ion binding]; other site 1231626001595 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535 1231626001596 biotin synthase; Region: bioB; TIGR00433 1231626001597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1231626001598 FeS/SAM binding site; other site 1231626001599 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1231626001600 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1231626001601 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1231626001602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1231626001603 catalytic residue [active] 1231626001604 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1231626001605 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1231626001606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1231626001607 S-adenosylmethionine binding site [chemical binding]; other site 1231626001608 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1231626001609 AAA domain; Region: AAA_26; pfam13500 1231626001610 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1231626001611 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1231626001612 inhibitor-cofactor binding pocket; inhibition site 1231626001613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1231626001614 catalytic residue [active] 1231626001615 transcription elongation factor GreA; Region: greA; TIGR01462 1231626001616 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1231626001617 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1231626001618 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1231626001619 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 1231626001620 GTP-binding protein YchF; Reviewed; Region: PRK09601 1231626001621 YchF GTPase; Region: YchF; cd01900 1231626001622 G1 box; other site 1231626001623 GTP/Mg2+ binding site [chemical binding]; other site 1231626001624 Switch I region; other site 1231626001625 G2 box; other site 1231626001626 Switch II region; other site 1231626001627 G3 box; other site 1231626001628 G4 box; other site 1231626001629 G5 box; other site 1231626001630 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1231626001631 CAAX protease self-immunity; Region: Abi; pfam02517 1231626001632 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1231626001633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1231626001634 FeS/SAM binding site; other site 1231626001635 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1231626001636 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1231626001637 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1231626001638 putative NAD(P) binding site [chemical binding]; other site 1231626001639 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1231626001640 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1231626001641 putative tRNA-binding site [nucleotide binding]; other site 1231626001642 B3/4 domain; Region: B3_4; pfam03483 1231626001643 tRNA synthetase B5 domain; Region: B5; pfam03484 1231626001644 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1231626001645 dimer interface [polypeptide binding]; other site 1231626001646 motif 1; other site 1231626001647 motif 3; other site 1231626001648 motif 2; other site 1231626001649 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1231626001650 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1231626001651 Cell division protein ZapA; Region: ZapA; pfam05164 1231626001652 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1231626001653 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1231626001654 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1231626001655 GTP/Mg2+ binding site [chemical binding]; other site 1231626001656 G4 box; other site 1231626001657 G5 box; other site 1231626001658 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1231626001659 G1 box; other site 1231626001660 G1 box; other site 1231626001661 GTP/Mg2+ binding site [chemical binding]; other site 1231626001662 Switch I region; other site 1231626001663 Switch I region; other site 1231626001664 G2 box; other site 1231626001665 G2 box; other site 1231626001666 Switch II region; other site 1231626001667 G3 box; other site 1231626001668 G4 box; other site 1231626001669 G5 box; other site 1231626001670 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1231626001671 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1231626001672 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1231626001673 dimerization interface 3.5A [polypeptide binding]; other site 1231626001674 active site 1231626001675 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1231626001676 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1231626001677 TrkA-C domain; Region: TrkA_C; pfam02080 1231626001678 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1231626001679 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1231626001680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1231626001681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1231626001682 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1231626001683 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1231626001684 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1231626001685 substrate binding site [chemical binding]; other site 1231626001686 oxyanion hole (OAH) forming residues; other site 1231626001687 trimer interface [polypeptide binding]; other site 1231626001688 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1231626001689 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1231626001690 RNA binding site [nucleotide binding]; other site 1231626001691 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1231626001692 RNA binding site [nucleotide binding]; other site 1231626001693 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1231626001694 RNA binding site [nucleotide binding]; other site 1231626001695 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1231626001696 RNA binding site [nucleotide binding]; other site 1231626001697 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1231626001698 RNA binding site [nucleotide binding]; other site 1231626001699 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1231626001700 RNA binding site [nucleotide binding]; other site 1231626001701 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1231626001702 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1231626001703 synthetase active site [active] 1231626001704 NTP binding site [chemical binding]; other site 1231626001705 metal binding site [ion binding]; metal-binding site 1231626001706 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001707 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001708 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001709 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001710 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001711 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001712 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1231626001713 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1231626001714 dimer interface [polypeptide binding]; other site 1231626001715 active site 1231626001716 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1231626001717 folate binding site [chemical binding]; other site 1231626001718 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1231626001719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626001720 Walker A/P-loop; other site 1231626001721 ATP binding site [chemical binding]; other site 1231626001722 Q-loop/lid; other site 1231626001723 ABC transporter signature motif; other site 1231626001724 Walker B; other site 1231626001725 D-loop; other site 1231626001726 H-loop/switch region; other site 1231626001727 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1231626001728 Permease; Region: Permease; pfam02405 1231626001729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626001730 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001731 Integrase core domain; Region: rve; pfam00665 1231626001732 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626001733 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626001734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626001735 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626001736 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001737 Integrase core domain; Region: rve; pfam00665 1231626001738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1231626001739 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 1231626001740 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001741 active site 1231626001742 HIGH motif; other site 1231626001743 nucleotide binding site [chemical binding]; other site 1231626001744 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1231626001745 active site 1231626001746 KMSKS motif; other site 1231626001747 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1231626001748 tRNA binding surface [nucleotide binding]; other site 1231626001749 anticodon binding site; other site 1231626001750 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1231626001751 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1231626001752 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1231626001753 active site 1231626001754 DNA binding site [nucleotide binding] 1231626001755 LysE type translocator; Region: LysE; cl00565 1231626001756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1231626001757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626001758 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1231626001759 Walker A/P-loop; other site 1231626001760 ATP binding site [chemical binding]; other site 1231626001761 Q-loop/lid; other site 1231626001762 ABC transporter signature motif; other site 1231626001763 Walker B; other site 1231626001764 D-loop; other site 1231626001765 H-loop/switch region; other site 1231626001766 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1231626001767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1231626001768 FeS/SAM binding site; other site 1231626001769 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1231626001770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001771 active site 1231626001772 HIGH motif; other site 1231626001773 nucleotide binding site [chemical binding]; other site 1231626001774 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1231626001775 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1231626001776 active site 1231626001777 KMSKS motif; other site 1231626001778 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1231626001779 tRNA binding surface [nucleotide binding]; other site 1231626001780 anticodon binding site; other site 1231626001781 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626001782 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1231626001783 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1231626001784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1231626001785 putative acyl-acceptor binding pocket; other site 1231626001786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1231626001787 Integrase core domain; Region: rve; pfam00665 1231626001788 Integrase core domain; Region: rve_3; pfam13683 1231626001789 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626001790 Na binding site [ion binding]; other site 1231626001791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1231626001792 Zn2+ binding site [ion binding]; other site 1231626001793 Mg2+ binding site [ion binding]; other site 1231626001794 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1231626001795 nudix motif; other site 1231626001796 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1231626001797 nudix motif; other site 1231626001798 replicative DNA helicase; Region: DnaB; TIGR00665 1231626001799 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1231626001800 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1231626001801 Walker A motif; other site 1231626001802 ATP binding site [chemical binding]; other site 1231626001803 Walker B motif; other site 1231626001804 DNA binding loops [nucleotide binding] 1231626001805 Fe-S metabolism associated domain; Region: SufE; cl00951 1231626001806 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1231626001807 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1231626001808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1231626001809 catalytic residue [active] 1231626001810 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1231626001811 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1231626001812 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1231626001813 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1231626001814 Walker A/P-loop; other site 1231626001815 ATP binding site [chemical binding]; other site 1231626001816 Q-loop/lid; other site 1231626001817 ABC transporter signature motif; other site 1231626001818 Walker B; other site 1231626001819 D-loop; other site 1231626001820 H-loop/switch region; other site 1231626001821 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1231626001822 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1231626001823 hinge region; other site 1231626001824 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1231626001825 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1231626001826 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626001827 Integrase core domain; Region: rve; pfam00665 1231626001828 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1231626001829 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1231626001830 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001831 MULE transposase domain; Region: MULE; pfam10551 1231626001832 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626001833 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626001834 Helix-turn-helix domain; Region: HTH_28; pfam13518 1231626001835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1231626001836 Integrase core domain; Region: rve; pfam00665 1231626001837 Integrase core domain; Region: rve_3; pfam13683 1231626001838 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001839 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001840 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001841 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626001842 Na binding site [ion binding]; other site 1231626001843 HD domain; Region: HD_4; pfam13328 1231626001844 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1231626001845 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1231626001846 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1231626001847 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1231626001848 NAD binding site [chemical binding]; other site 1231626001849 Phe binding site; other site 1231626001850 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1231626001851 Competence protein; Region: Competence; pfam03772 1231626001852 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1231626001853 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1231626001854 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1231626001855 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1231626001856 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1231626001857 Probable Catalytic site; other site 1231626001858 metal-binding site 1231626001859 hypothetical protein; Validated; Region: PRK00153 1231626001860 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1231626001861 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1231626001862 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1231626001863 endonuclease IV; Provisional; Region: PRK01060 1231626001864 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1231626001865 AP (apurinic/apyrimidinic) site pocket; other site 1231626001866 DNA interaction; other site 1231626001867 Metal-binding active site; metal-binding site 1231626001868 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1231626001869 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1231626001870 Catalytic site [active] 1231626001871 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1231626001872 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1231626001873 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1231626001874 dimer interface [polypeptide binding]; other site 1231626001875 motif 1; other site 1231626001876 active site 1231626001877 motif 2; other site 1231626001878 motif 3; other site 1231626001879 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1231626001880 anticodon binding site; other site 1231626001881 zinc-binding site [ion binding]; other site 1231626001882 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1231626001883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1231626001884 FtsX-like permease family; Region: FtsX; pfam02687 1231626001885 UGMP family protein; Validated; Region: PRK09604 1231626001886 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1231626001887 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1231626001888 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1231626001889 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1231626001890 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1231626001891 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1231626001892 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1231626001893 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1231626001894 ligand binding site [chemical binding]; other site 1231626001895 active site 1231626001896 UGI interface [polypeptide binding]; other site 1231626001897 catalytic site [active] 1231626001898 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1231626001899 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1231626001900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626001901 Walker A motif; other site 1231626001902 ATP binding site [chemical binding]; other site 1231626001903 Walker B motif; other site 1231626001904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1231626001905 arginine finger; other site 1231626001906 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1231626001907 DnaA box-binding interface [nucleotide binding]; other site 1231626001908 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1231626001909 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1231626001910 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1231626001911 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1231626001912 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1231626001913 transmembrane helices; other site 1231626001914 YcxB-like protein; Region: YcxB; pfam14317 1231626001915 SurA N-terminal domain; Region: SurA_N_3; cl07813 1231626001916 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1231626001917 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1231626001918 DHH family; Region: DHH; pfam01368 1231626001919 DHHA1 domain; Region: DHHA1; pfam02272 1231626001920 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1231626001921 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001922 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001923 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001924 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1231626001925 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1231626001926 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1231626001927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1231626001928 ATP binding site [chemical binding]; other site 1231626001929 putative Mg++ binding site [ion binding]; other site 1231626001930 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1231626001931 ATP-binding site [chemical binding]; other site 1231626001932 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 1231626001933 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1231626001934 active site 1231626001935 catalytic site [active] 1231626001936 substrate binding site [chemical binding]; other site 1231626001937 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1231626001938 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1231626001939 minor groove reading motif; other site 1231626001940 helix-hairpin-helix signature motif; other site 1231626001941 substrate binding pocket [chemical binding]; other site 1231626001942 active site 1231626001943 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1231626001944 DNA binding and oxoG recognition site [nucleotide binding] 1231626001945 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1231626001946 DNA-binding site [nucleotide binding]; DNA binding site 1231626001947 RNA-binding motif; other site 1231626001948 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1231626001949 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1231626001950 ATP binding site [chemical binding]; other site 1231626001951 Mg++ binding site [ion binding]; other site 1231626001952 motif III; other site 1231626001953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1231626001954 nucleotide binding region [chemical binding]; other site 1231626001955 ATP-binding site [chemical binding]; other site 1231626001956 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1231626001957 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626001958 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001959 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001960 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001961 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001962 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001963 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001964 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001965 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001966 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001967 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001968 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001969 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001970 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001971 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001972 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626001973 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001974 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626001975 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626001976 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626001977 Integrase core domain; Region: rve; pfam00665 1231626001978 Transposase; Region: HTH_Tnp_1; cl17663 1231626001979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626001980 HTH-like domain; Region: HTH_21; pfam13276 1231626001981 Integrase core domain; Region: rve; pfam00665 1231626001982 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626001983 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1231626001984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1231626001985 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1231626001986 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1231626001987 HflX GTPase family; Region: HflX; cd01878 1231626001988 G1 box; other site 1231626001989 GTP/Mg2+ binding site [chemical binding]; other site 1231626001990 Switch I region; other site 1231626001991 G2 box; other site 1231626001992 G3 box; other site 1231626001993 Switch II region; other site 1231626001994 G4 box; other site 1231626001995 G5 box; other site 1231626001996 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1231626001997 phosphoglyceromutase; Provisional; Region: PRK05434 1231626001998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1231626001999 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1231626002000 RNA binding surface [nucleotide binding]; other site 1231626002001 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1231626002002 active site 1231626002003 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1231626002004 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1231626002005 Putative zinc ribbon domain; Region: DUF164; pfam02591 1231626002006 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1231626002007 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1231626002008 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1231626002009 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 1231626002010 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1231626002011 ATP synthase A chain; Region: ATP-synt_A; cl00413 1231626002012 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1231626002013 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1231626002014 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1231626002015 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 1231626002016 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1231626002017 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1231626002018 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1231626002019 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1231626002020 Walker A motif; other site 1231626002021 ATP binding site [chemical binding]; other site 1231626002022 Walker B motif; other site 1231626002023 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1231626002024 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1231626002025 core domain interface [polypeptide binding]; other site 1231626002026 delta subunit interface [polypeptide binding]; other site 1231626002027 epsilon subunit interface [polypeptide binding]; other site 1231626002028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1231626002029 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002030 MULE transposase domain; Region: MULE; pfam10551 1231626002031 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1231626002032 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1231626002033 NADP binding site [chemical binding]; other site 1231626002034 active site 1231626002035 putative substrate binding site [chemical binding]; other site 1231626002036 GTP-binding protein Der; Reviewed; Region: PRK00093 1231626002037 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1231626002038 G1 box; other site 1231626002039 GTP/Mg2+ binding site [chemical binding]; other site 1231626002040 Switch I region; other site 1231626002041 G2 box; other site 1231626002042 Switch II region; other site 1231626002043 G3 box; other site 1231626002044 G4 box; other site 1231626002045 G5 box; other site 1231626002046 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1231626002047 G1 box; other site 1231626002048 GTP/Mg2+ binding site [chemical binding]; other site 1231626002049 Switch I region; other site 1231626002050 G2 box; other site 1231626002051 G3 box; other site 1231626002052 Switch II region; other site 1231626002053 G4 box; other site 1231626002054 G5 box; other site 1231626002055 mce related protein; Region: MCE; pfam02470 1231626002056 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1231626002057 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1231626002058 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1231626002059 PLD-like domain; Region: PLDc_2; pfam13091 1231626002060 putative active site [active] 1231626002061 catalytic site [active] 1231626002062 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1231626002063 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1231626002064 ligand binding site [chemical binding]; other site 1231626002065 Protein of unknown function (DUF502); Region: DUF502; pfam04367 1231626002066 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1231626002067 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1231626002068 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1231626002069 FeoA domain; Region: FeoA; pfam04023 1231626002070 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1231626002071 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1231626002072 intersubunit interface [polypeptide binding]; other site 1231626002073 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1231626002074 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1231626002075 intersubunit interface [polypeptide binding]; other site 1231626002076 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1231626002077 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1231626002078 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1231626002079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626002080 Walker A motif; other site 1231626002081 ATP binding site [chemical binding]; other site 1231626002082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626002083 Walker B motif; other site 1231626002084 arginine finger; other site 1231626002085 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1231626002086 RIP metalloprotease RseP; Region: TIGR00054 1231626002087 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1231626002088 active site 1231626002089 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1231626002090 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1231626002091 protein binding site [polypeptide binding]; other site 1231626002092 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1231626002093 putative substrate binding region [chemical binding]; other site 1231626002094 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1231626002095 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1231626002096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626002097 Walker A motif; other site 1231626002098 ATP binding site [chemical binding]; other site 1231626002099 Walker B motif; other site 1231626002100 arginine finger; other site 1231626002101 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1231626002102 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1231626002103 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1231626002104 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1231626002105 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1231626002106 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1231626002107 active site 1231626002108 PHP Thumb interface [polypeptide binding]; other site 1231626002109 metal binding site [ion binding]; metal-binding site 1231626002110 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1231626002111 generic binding surface II; other site 1231626002112 generic binding surface I; other site 1231626002113 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1231626002114 catalytic residues [active] 1231626002115 dimer interface [polypeptide binding]; other site 1231626002116 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1231626002117 hypothetical protein; Validated; Region: PRK00110 1231626002118 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1231626002119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626002120 Walker A motif; other site 1231626002121 ATP binding site [chemical binding]; other site 1231626002122 Walker B motif; other site 1231626002123 arginine finger; other site 1231626002124 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1231626002125 CAAX protease self-immunity; Region: Abi; pfam02517 1231626002126 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1231626002127 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1231626002128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626002129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1231626002130 Walker A/P-loop; other site 1231626002131 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1231626002132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1231626002133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002134 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1231626002135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1231626002136 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002137 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1231626002138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1231626002139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626002140 Walker A/P-loop; other site 1231626002141 ATP binding site [chemical binding]; other site 1231626002142 Q-loop/lid; other site 1231626002143 ABC transporter signature motif; other site 1231626002144 Walker B; other site 1231626002145 D-loop; other site 1231626002146 H-loop/switch region; other site 1231626002147 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1231626002148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626002149 Walker A/P-loop; other site 1231626002150 ATP binding site [chemical binding]; other site 1231626002151 Q-loop/lid; other site 1231626002152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1231626002153 ABC transporter signature motif; other site 1231626002154 Walker B; other site 1231626002155 D-loop; other site 1231626002156 ABC transporter; Region: ABC_tran_2; pfam12848 1231626002157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1231626002158 lipoyl synthase; Provisional; Region: PRK05481 1231626002159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1231626002160 FeS/SAM binding site; other site 1231626002161 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1231626002162 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1231626002163 Clp protease; Region: CLP_protease; pfam00574 1231626002164 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1231626002165 oligomer interface [polypeptide binding]; other site 1231626002166 active site residues [active] 1231626002167 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1231626002168 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1231626002169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626002170 Walker A motif; other site 1231626002171 ATP binding site [chemical binding]; other site 1231626002172 Walker B motif; other site 1231626002173 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1231626002174 D-alanyl-alanine synthetase A; Provisional; Region: PRK14572 1231626002175 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1231626002176 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1231626002177 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1231626002178 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1231626002179 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1231626002180 dimer interface [polypeptide binding]; other site 1231626002181 ssDNA binding site [nucleotide binding]; other site 1231626002182 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1231626002183 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1231626002184 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1231626002185 interface (dimer of trimers) [polypeptide binding]; other site 1231626002186 Substrate-binding/catalytic site; other site 1231626002187 Zn-binding sites [ion binding]; other site 1231626002188 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1231626002189 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1231626002190 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1231626002191 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1231626002192 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1231626002193 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1231626002194 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1231626002195 23S rRNA binding site [nucleotide binding]; other site 1231626002196 L21 binding site [polypeptide binding]; other site 1231626002197 L13 binding site [polypeptide binding]; other site 1231626002198 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1231626002199 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1231626002200 RF-1 domain; Region: RF-1; pfam00472 1231626002201 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1231626002202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1231626002203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626002204 Walker A/P-loop; other site 1231626002205 ATP binding site [chemical binding]; other site 1231626002206 Q-loop/lid; other site 1231626002207 ABC transporter signature motif; other site 1231626002208 Walker B; other site 1231626002209 D-loop; other site 1231626002210 H-loop/switch region; other site 1231626002211 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1231626002212 catalytic residues [active] 1231626002213 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1231626002214 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1231626002215 motif 1; other site 1231626002216 active site 1231626002217 motif 2; other site 1231626002218 motif 3; other site 1231626002219 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1231626002220 DHHA1 domain; Region: DHHA1; pfam02272 1231626002221 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1231626002222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626002223 Walker A/P-loop; other site 1231626002224 ATP binding site [chemical binding]; other site 1231626002225 Q-loop/lid; other site 1231626002226 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1231626002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1231626002228 Walker A/P-loop; other site 1231626002229 ATP binding site [chemical binding]; other site 1231626002230 Q-loop/lid; other site 1231626002231 ABC transporter signature motif; other site 1231626002232 Walker B; other site 1231626002233 D-loop; other site 1231626002234 H-loop/switch region; other site 1231626002235 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1231626002236 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1231626002237 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1231626002238 Uncharacterized conserved protein [Function unknown]; Region: COG4104 1231626002239 Phage protein D [General function prediction only]; Region: COG3500 1231626002240 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1231626002241 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1231626002242 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1231626002243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1231626002244 ATP binding site [chemical binding]; other site 1231626002245 putative Mg++ binding site [ion binding]; other site 1231626002246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1231626002247 nucleotide binding region [chemical binding]; other site 1231626002248 ATP-binding site [chemical binding]; other site 1231626002249 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1231626002250 acetyl-CoA synthetase; Provisional; Region: PRK00174 1231626002251 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1231626002252 active site 1231626002253 CoA binding site [chemical binding]; other site 1231626002254 acyl-activating enzyme (AAE) consensus motif; other site 1231626002255 AMP binding site [chemical binding]; other site 1231626002256 acetate binding site [chemical binding]; other site 1231626002257 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 1231626002258 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1231626002259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1231626002260 FeS/SAM binding site; other site 1231626002261 TRAM domain; Region: TRAM; pfam01938 1231626002262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1231626002263 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1231626002264 Walker A motif; other site 1231626002265 ATP binding site [chemical binding]; other site 1231626002266 Walker B motif; other site 1231626002267 arginine finger; other site 1231626002268 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1231626002269 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1231626002270 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1231626002271 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1231626002272 active site 1231626002273 HD domain; Region: HD_4; pfam13328 1231626002274 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1231626002275 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1231626002276 NAD binding site [chemical binding]; other site 1231626002277 substrate binding site [chemical binding]; other site 1231626002278 homodimer interface [polypeptide binding]; other site 1231626002279 active site 1231626002280 putative hydrolase; Provisional; Region: PRK11460 1231626002281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1231626002282 PGAP1-like protein; Region: PGAP1; pfam07819 1231626002283 DNA polymerase III subunit beta; Validated; Region: PRK05643 1231626002284 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1231626002285 putative DNA binding surface [nucleotide binding]; other site 1231626002286 dimer interface [polypeptide binding]; other site 1231626002287 beta-clamp/clamp loader binding surface; other site 1231626002288 beta-clamp/translesion DNA polymerase binding surface; other site 1231626002289 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1231626002290 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1231626002291 folate binding site [chemical binding]; other site 1231626002292 NADP+ binding site [chemical binding]; other site 1231626002293 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1231626002294 active site 1231626002295 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1231626002296 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1231626002297 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1231626002298 FtsX-like permease family; Region: FtsX; pfam02687 1231626002299 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1231626002300 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1231626002301 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1231626002302 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1231626002303 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002304 Integrase core domain; Region: rve; pfam00665 1231626002305 TLC ATP/ADP transporter; Region: TLC; cl03940 1231626002306 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1231626002307 transcription termination factor NusA; Region: NusA; TIGR01953 1231626002308 NusA N-terminal domain; Region: NusA_N; pfam08529 1231626002309 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1231626002310 RNA binding site [nucleotide binding]; other site 1231626002311 homodimer interface [polypeptide binding]; other site 1231626002312 NusA-like KH domain; Region: KH_5; pfam13184 1231626002313 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1231626002314 G-X-X-G motif; other site 1231626002315 Remorin, C-terminal region; Region: Remorin_C; pfam03763 1231626002316 translation initiation factor IF-2; Region: IF-2; TIGR00487 1231626002317 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1231626002318 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1231626002319 G1 box; other site 1231626002320 putative GEF interaction site [polypeptide binding]; other site 1231626002321 GTP/Mg2+ binding site [chemical binding]; other site 1231626002322 Switch I region; other site 1231626002323 G2 box; other site 1231626002324 G3 box; other site 1231626002325 Switch II region; other site 1231626002326 G4 box; other site 1231626002327 G5 box; other site 1231626002328 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1231626002329 Translation-initiation factor 2; Region: IF-2; pfam11987 1231626002330 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1231626002331 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1231626002332 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1231626002333 RNA binding surface [nucleotide binding]; other site 1231626002334 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1231626002335 active site 1231626002336 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1231626002337 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1231626002338 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1231626002339 Na binding site [ion binding]; other site 1231626002340 HD domain; Region: HD_4; pfam13328 1231626002341 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1231626002342 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1231626002343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1231626002344 catalytic residue [active] 1231626002345 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1231626002346 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1231626002347 nucleotide binding pocket [chemical binding]; other site 1231626002348 K-X-D-G motif; other site 1231626002349 catalytic site [active] 1231626002350 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1231626002351 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1231626002352 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1231626002353 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1231626002354 Dimer interface [polypeptide binding]; other site 1231626002355 BRCT sequence motif; other site 1231626002356 ZIP Zinc transporter; Region: Zip; pfam02535 1231626002357 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1231626002358 MraW methylase family; Region: Methyltransf_5; cl17771 1231626002359 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1231626002360 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1231626002361 synthetase active site [active] 1231626002362 NTP binding site [chemical binding]; other site 1231626002363 metal binding site [ion binding]; metal-binding site 1231626002364 YceG-like family; Region: YceG; pfam02618 1231626002365 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1231626002366 dimerization interface [polypeptide binding]; other site 1231626002367 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1231626002368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1231626002369 ATP binding site [chemical binding]; other site 1231626002370 Mg2+ binding site [ion binding]; other site 1231626002371 G-X-G motif; other site 1231626002372 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1231626002373 ATP binding site [chemical binding]; other site 1231626002374 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1231626002375 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1231626002376 proline aminopeptidase P II; Provisional; Region: PRK10879 1231626002377 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1231626002378 active site 1231626002379 Transposase; Region: HTH_Tnp_1; cl17663 1231626002380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626002381 Transposase; Region: HTH_Tnp_1; cl17663 1231626002382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626002383 Transposase; Region: HTH_Tnp_1; cl17663 1231626002384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626002385 HTH-like domain; Region: HTH_21; pfam13276 1231626002386 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002387 Integrase core domain; Region: rve; pfam00665 1231626002388 Integrase core domain; Region: rve_3; pfam13683 1231626002389 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002390 Integrase core domain; Region: rve; pfam00665 1231626002391 Integrase core domain; Region: rve_3; pfam13683 1231626002392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1231626002393 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1231626002394 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002395 MULE transposase domain; Region: MULE; pfam10551 1231626002396 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1231626002397 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1231626002398 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1231626002399 catalytic residues [active] 1231626002400 catalytic nucleophile [active] 1231626002401 Presynaptic Site I dimer interface [polypeptide binding]; other site 1231626002402 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1231626002403 Synaptic Flat tetramer interface [polypeptide binding]; other site 1231626002404 Synaptic Site I dimer interface [polypeptide binding]; other site 1231626002405 DNA binding site [nucleotide binding] 1231626002406 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1231626002407 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1231626002408 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 1231626002409 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 1231626002410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002411 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1231626002412 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1231626002413 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1231626002414 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1231626002415 catalytic residues [active] 1231626002416 catalytic nucleophile [active] 1231626002417 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1231626002418 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1231626002419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002420 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1231626002421 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1231626002422 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1231626002423 DNA binding site [nucleotide binding] 1231626002424 active site 1231626002425 Int/Topo IB signature motif; other site 1231626002426 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626002427 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626002428 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002429 Integrase core domain; Region: rve; pfam00665 1231626002430 Transposase; Region: HTH_Tnp_1; cl17663 1231626002431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626002432 HTH-like domain; Region: HTH_21; pfam13276 1231626002433 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002434 Integrase core domain; Region: rve; pfam00665 1231626002435 Integrase core domain; Region: rve_3; pfam13683 1231626002436 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002437 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 1231626002438 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002439 enolase; Provisional; Region: eno; PRK00077 1231626002440 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1231626002441 dimer interface [polypeptide binding]; other site 1231626002442 metal binding site [ion binding]; metal-binding site 1231626002443 substrate binding pocket [chemical binding]; other site 1231626002444 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1231626002445 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1231626002446 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1231626002447 catalytic residue [active] 1231626002448 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1231626002449 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1231626002450 metabolite-proton symporter; Region: 2A0106; TIGR00883 1231626002451 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002452 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1231626002454 Homeodomain-like domain; Region: HTH_23; cl17451 1231626002455 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002456 MULE transposase domain; Region: MULE; pfam10551 1231626002457 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1231626002458 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1231626002459 putative dimer interface [polypeptide binding]; other site 1231626002460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002461 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1231626002462 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1231626002463 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626002464 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626002465 Winged helix-turn helix; Region: HTH_29; pfam13551 1231626002466 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1231626002467 active site 1231626002468 catalytic residues [active] 1231626002469 DNA binding site [nucleotide binding] 1231626002470 Int/Topo IB signature motif; other site 1231626002471 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626002472 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002473 Integrase core domain; Region: rve; pfam00665 1231626002474 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002475 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002477 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1231626002478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002479 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1231626002480 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1231626002481 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1231626002482 catalytic residues [active] 1231626002483 catalytic nucleophile [active] 1231626002484 putative transposase; Provisional; Region: PRK09857 1231626002485 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1231626002486 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626002487 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002488 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002489 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 1231626002490 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002491 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002492 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626002493 AAA-like domain; Region: AAA_10; pfam12846 1231626002494 Domain of unknown function DUF87; Region: DUF87; pfam01935 1231626002495 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002496 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002497 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002498 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002499 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002500 Zinc finger, C3HC4 type (RING finger); Region: zf-C3HC4_2; pfam13923 1231626002501 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cd00162 1231626002502 cross-brace motif; other site 1231626002503 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002504 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002505 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1231626002506 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1231626002507 Walker A motif; other site 1231626002508 ATP binding site [chemical binding]; other site 1231626002509 Walker B motif; other site 1231626002510 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1231626002511 basic region leucin zipper; Region: BRLZ; smart00338 1231626002512 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 1231626002513 active site 1231626002514 metal binding site [ion binding]; metal-binding site 1231626002515 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1231626002516 active site 1231626002517 interdomain interaction site; other site 1231626002518 metal binding site [ion binding]; metal-binding site 1231626002519 Virulence-associated protein E; Region: VirE; pfam05272 1231626002520 ParA-like protein; Provisional; Region: PHA02518 1231626002521 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1231626002522 Magnesium ion binding site [ion binding]; other site 1231626002523 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626002524 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002525 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002526 MULE transposase domain; Region: MULE; pfam10551 1231626002527 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002528 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002529 Integrase core domain; Region: rve; pfam00665 1231626002530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1231626002531 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1231626002532 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1231626002533 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1231626002534 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1231626002535 P-loop; other site 1231626002536 Magnesium ion binding site [ion binding]; other site 1231626002537 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1231626002538 Magnesium ion binding site [ion binding]; other site 1231626002539 Toprim-like; Region: Toprim_2; pfam13155 1231626002540 active site 1231626002541 metal binding site [ion binding]; metal-binding site 1231626002542 Virulence-associated protein E; Region: VirE; pfam05272 1231626002543 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 1231626002544 active site 1231626002545 metal binding site [ion binding]; metal-binding site 1231626002546 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002547 Integrase core domain; Region: rve; pfam00665 1231626002548 Integrase core domain; Region: rve_3; pfam13683 1231626002549 Transposase; Region: HTH_Tnp_1; cl17663 1231626002550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626002551 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002552 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1231626002553 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1231626002554 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002555 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1231626002556 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1231626002557 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1231626002558 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1231626002559 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002560 Transposase; Region: HTH_Tnp_1; cl17663 1231626002561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1231626002562 HTH-like domain; Region: HTH_21; pfam13276 1231626002563 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1231626002564 Integrase core domain; Region: rve; pfam00665 1231626002565 Integrase core domain; Region: rve_3; pfam13683 1231626002566 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1231626002567 MULE transposase domain; Region: MULE; pfam10551