-- dump date   	20140619_025919
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1266845000001	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1266845000002	Initiator Replication protein; Region: Rep_3; pfam01051
1266845000003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266845000004	Coenzyme A binding pocket [chemical binding]; other site
1266845000005	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266845000006	active site
1266845000007	DNA binding site [nucleotide binding]
1266845000008	Int/Topo IB signature motif; other site
1266845000009	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1266845000010	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1266845000011	Integrase core domain; Region: rve; pfam00665
1266845000012	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1266845000013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1266845000014	Integrase core domain; Region: rve; pfam00665
1266845000015	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1266845000016	Integrase core domain; Region: rve; pfam00665
1266845000017	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1266845000018	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1266845000019	Cadmium resistance transporter; Region: Cad; pfam03596
1266845000020	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266845000021	dimerization interface [polypeptide binding]; other site
1266845000022	putative DNA binding site [nucleotide binding]; other site
1266845000023	putative Zn2+ binding site [ion binding]; other site
1266845000024	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1266845000025	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
1266845000026	MobA/MobL family; Region: MobA_MobL; pfam03389
1266845000027	Domain of unknown function DUF87; Region: DUF87; pfam01935
1266845000028	AAA-like domain; Region: AAA_10; pfam12846
1266845000029	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266845000030	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266845000031	catalytic residue [active]
1266845000032	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1266845000033	Peptidase family M23; Region: Peptidase_M23; pfam01551
1266845000034	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
1266845000035	AAA-like domain; Region: AAA_10; pfam12846
1266845000036	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1266845000037	Walker A motif; other site
1266845000038	ATP binding site [chemical binding]; other site
1266845000039	Walker B motif; other site
1266845000040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1266845000041	Integrase core domain; Region: rve; pfam00665
1266845000042	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1266845000043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266845000044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845000045	non-specific DNA binding site [nucleotide binding]; other site
1266845000046	salt bridge; other site
1266845000047	sequence-specific DNA binding site [nucleotide binding]; other site
1266845000048	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1266845000049	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1266845000050	active site
1266845000051	ATP binding site [chemical binding]; other site
1266845000052	substrate binding site [chemical binding]; other site
1266845000053	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845000054	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1266845000055	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1266845000056	Walker A/P-loop; other site
1266845000057	ATP binding site [chemical binding]; other site
1266845000058	Q-loop/lid; other site
1266845000059	ABC transporter signature motif; other site
1266845000060	Walker B; other site
1266845000061	D-loop; other site
1266845000062	H-loop/switch region; other site
1266845000063	YcxB-like protein; Region: YcxB; pfam14317
1266845000064	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1266845000065	MULE transposase domain; Region: MULE; pfam10551
1266845000066	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266845000067	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266845000068	catalytic residues [active]
1266845000069	catalytic nucleophile [active]
1266845000070	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266845000071	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266845000072	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266845000073	Synaptic Site I dimer interface [polypeptide binding]; other site
1266845000074	DNA binding site [nucleotide binding]
1266845000075	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1266845000076	DNA-binding interface [nucleotide binding]; DNA binding site
1266845000077	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266845000078	AAA ATPase domain; Region: AAA_16; pfam13191
1266845000079	Fic family protein [Function unknown]; Region: COG3177
1266845000080	Fic/DOC family; Region: Fic; pfam02661
1266845000081	AAA domain; Region: AAA_31; pfam13614
1266845000082	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1266845000083	P-loop; other site
1266845000084	Magnesium ion binding site [ion binding]; other site
1266845000085	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1266845000086	Magnesium ion binding site [ion binding]; other site
1266845000087	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1266845000088	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1266845000089	catalytic triad [active]
1266845000090	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
1266845000091	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1266845000092	Integrase core domain; Region: rve; pfam00665
1266845000093	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845000094	non-specific DNA binding site [nucleotide binding]; other site
1266845000095	salt bridge; other site
1266845000096	sequence-specific DNA binding site [nucleotide binding]; other site
1266845000097	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1266845000098	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1266845000099	YcxB-like protein; Region: YcxB; pfam14317
1266845000100	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1266845000101	Int/Topo IB signature motif; other site
1266845000102	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1266845000103	conserved cys residue [active]
1266845000104	Domain of unknown function (DUF955); Region: DUF955; cl01076
1266845000105	Domain of unknown function DUF87; Region: DUF87; pfam01935
1266845000106	AAA-like domain; Region: AAA_10; pfam12846
1266845000107	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1266845000108	cell division protein MukB; Provisional; Region: mukB; PRK04863
1266845000109	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266845000110	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266845000111	catalytic residue [active]
1266845000112	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1266845000113	Peptidase family M23; Region: Peptidase_M23; pfam01551
1266845000114	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
1266845000115	AAA-like domain; Region: AAA_10; pfam12846
1266845000116	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1266845000117	Walker A motif; other site
1266845000118	ATP binding site [chemical binding]; other site
1266845000119	Walker B motif; other site
1266845000120	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1266845000121	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1266845000122	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1266845000123	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1266845000124	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1266845000125	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266845000126	metal-binding site [ion binding]
1266845000127	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1266845000128	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266845000129	metal-binding site [ion binding]
1266845000130	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266845000131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266845000132	motif II; other site
1266845000133	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266845000134	metal-binding site [ion binding]
1266845000135	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
1266845000136	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1266845000137	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266845000138	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1266845000139	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
1266845000140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1266845000141	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1266845000142	Peptidase family M23; Region: Peptidase_M23; pfam01551
1266845000143	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1266845000144	Short C-terminal domain; Region: SHOCT; pfam09851
1266845000145	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1266845000146	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1266845000147	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1266845000148	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1266845000149	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1266845000150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266845000151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1266845000152	Integrase core domain; Region: rve; pfam00665
1266845000153	HAMP domain; Region: HAMP; pfam00672
1266845000154	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266845000155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266845000156	dimer interface [polypeptide binding]; other site
1266845000157	phosphorylation site [posttranslational modification]
1266845000158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845000159	ATP binding site [chemical binding]; other site
1266845000160	Mg2+ binding site [ion binding]; other site
1266845000161	G-X-G motif; other site
1266845000162	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266845000163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845000164	active site
1266845000165	phosphorylation site [posttranslational modification]
1266845000166	intermolecular recognition site; other site
1266845000167	dimerization interface [polypeptide binding]; other site
1266845000168	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266845000169	DNA binding site [nucleotide binding]
1266845000170	multicopper oxidase; Provisional; Region: PRK10965
1266845000171	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1266845000172	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1266845000173	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1266845000174	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1266845000175	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266845000176	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266845000177	catalytic residues [active]
1266845000178	catalytic nucleophile [active]
1266845000179	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266845000180	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266845000181	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266845000182	Synaptic Site I dimer interface [polypeptide binding]; other site
1266845000183	DNA binding site [nucleotide binding]
1266845000184	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1266845000185	DNA-binding interface [nucleotide binding]; DNA binding site
1266845000186	Cupin domain; Region: Cupin_2; pfam07883
1266845000187	Helix-turn-helix domain; Region: HTH_18; pfam12833
1266845000188	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266845000189	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1266845000190	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1266845000191	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1266845000192	beta-galactosidase; Region: BGL; TIGR03356
1266845000193	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1266845000194	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1266845000195	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1266845000196	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266845000197	motif II; other site
1266845000198	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1266845000199	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1266845000200	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
1266845000201	putative active site [active]
1266845000202	YdjC motif; other site
1266845000203	Mg binding site [ion binding]; other site
1266845000204	putative homodimer interface [polypeptide binding]; other site
1266845000205	allantoate amidohydrolase; Reviewed; Region: PRK09290
1266845000206	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1266845000207	active site
1266845000208	metal binding site [ion binding]; metal-binding site
1266845000209	dimer interface [polypeptide binding]; other site
1266845000210	Fic family protein [Function unknown]; Region: COG3177
1266845000211	Fic/DOC family; Region: Fic; pfam02661
1266845000212	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1266845000213	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1266845000214	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1266845000215	Magnesium ion binding site [ion binding]; other site
1266845000216	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1266845000217	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1266845000218	catalytic triad [active]
1266845000219	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845000220	non-specific DNA binding site [nucleotide binding]; other site
1266845000221	salt bridge; other site
1266845000222	sequence-specific DNA binding site [nucleotide binding]; other site
1266845000223	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1266845000224	Ferritin-like domain; Region: Ferritin; pfam00210
1266845000225	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1266845000226	dimerization interface [polypeptide binding]; other site
1266845000227	DPS ferroxidase diiron center [ion binding]; other site
1266845000228	ion pore; other site
1266845000229	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1266845000230	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1266845000231	ligand binding site [chemical binding]; other site
1266845000232	flexible hinge region; other site
1266845000233	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1266845000234	putative switch regulator; other site
1266845000235	non-specific DNA interactions [nucleotide binding]; other site
1266845000236	DNA binding site [nucleotide binding]
1266845000237	sequence specific DNA binding site [nucleotide binding]; other site
1266845000238	putative cAMP binding site [chemical binding]; other site
1266845000239	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1266845000240	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266845000241	metal-binding site [ion binding]
1266845000242	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1266845000243	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266845000244	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1266845000245	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1266845000246	Int/Topo IB signature motif; other site
1266845000247	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845000248	Walker A/P-loop; other site
1266845000249	ATP binding site [chemical binding]; other site
1266845000250	Q-loop/lid; other site
1266845000251	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845000252	ABC transporter signature motif; other site
1266845000253	Walker B; other site
1266845000254	D-loop; other site
1266845000255	H-loop/switch region; other site
1266845000256	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845000257	AAA domain; Region: AAA_21; pfam13304
1266845000258	Walker A/P-loop; other site
1266845000259	ATP binding site [chemical binding]; other site
1266845000260	Q-loop/lid; other site
1266845000261	ABC transporter signature motif; other site
1266845000262	Walker B; other site
1266845000263	D-loop; other site
1266845000264	H-loop/switch region; other site
1266845000265	Initiator Replication protein; Region: Rep_3; pfam01051
1266845000266	Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430
1266845000267	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1266845000268	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1266845000269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266845000270	Walker A motif; other site
1266845000271	ATP binding site [chemical binding]; other site
1266845000272	Walker B motif; other site
1266845000273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266845000274	arginine finger; other site
1266845000275	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1266845000276	DnaA box-binding interface [nucleotide binding]; other site
1266845000277	DNA polymerase III subunit beta; Validated; Region: PRK05643
1266845000278	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1266845000279	putative DNA binding surface [nucleotide binding]; other site
1266845000280	dimer interface [polypeptide binding]; other site
1266845000281	beta-clamp/clamp loader binding surface; other site
1266845000282	beta-clamp/translesion DNA polymerase binding surface; other site
1266845000283	S4 domain; Region: S4_2; pfam13275
1266845000284	recombination protein F; Reviewed; Region: recF; PRK00064
1266845000285	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1266845000286	Walker A/P-loop; other site
1266845000287	ATP binding site [chemical binding]; other site
1266845000288	Q-loop/lid; other site
1266845000289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845000290	ABC transporter signature motif; other site
1266845000291	Walker B; other site
1266845000292	D-loop; other site
1266845000293	H-loop/switch region; other site
1266845000294	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1266845000295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845000296	Mg2+ binding site [ion binding]; other site
1266845000297	G-X-G motif; other site
1266845000298	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1266845000299	anchoring element; other site
1266845000300	dimer interface [polypeptide binding]; other site
1266845000301	ATP binding site [chemical binding]; other site
1266845000302	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1266845000303	active site
1266845000304	putative metal-binding site [ion binding]; other site
1266845000305	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1266845000306	DNA gyrase subunit A; Validated; Region: PRK05560
1266845000307	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1266845000308	CAP-like domain; other site
1266845000309	active site
1266845000310	primary dimer interface [polypeptide binding]; other site
1266845000311	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266845000312	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266845000313	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266845000314	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266845000315	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266845000316	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266845000317	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1266845000318	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1266845000319	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1266845000320	dimer interface [polypeptide binding]; other site
1266845000321	ssDNA binding site [nucleotide binding]; other site
1266845000322	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1266845000323	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1266845000324	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1266845000325	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1266845000326	DHH family; Region: DHH; pfam01368
1266845000327	DHHA1 domain; Region: DHHA1; pfam02272
1266845000328	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1266845000329	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1266845000330	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1266845000331	replicative DNA helicase; Provisional; Region: PRK05748
1266845000332	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1266845000333	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1266845000334	Walker A motif; other site
1266845000335	ATP binding site [chemical binding]; other site
1266845000336	Walker B motif; other site
1266845000337	DNA binding loops [nucleotide binding]
1266845000338	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1266845000339	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1266845000340	GDP-binding site [chemical binding]; other site
1266845000341	ACT binding site; other site
1266845000342	IMP binding site; other site
1266845000343	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1266845000344	ZIP Zinc transporter; Region: Zip; pfam02535
1266845000345	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1266845000346	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1266845000347	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1266845000348	active site
1266845000349	Na/Ca binding site [ion binding]; other site
1266845000350	catalytic site [active]
1266845000351	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1266845000352	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1266845000353	substrate binding site [chemical binding]; other site
1266845000354	multimerization interface [polypeptide binding]; other site
1266845000355	ATP binding site [chemical binding]; other site
1266845000356	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1266845000357	dimer interface [polypeptide binding]; other site
1266845000358	substrate binding site [chemical binding]; other site
1266845000359	ATP binding site [chemical binding]; other site
1266845000360	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1266845000361	thiamine phosphate binding site [chemical binding]; other site
1266845000362	active site
1266845000363	pyrophosphate binding site [ion binding]; other site
1266845000364	YtxH-like protein; Region: YtxH; pfam12732
1266845000365	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1266845000366	HPr interaction site; other site
1266845000367	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1266845000368	active site
1266845000369	phosphorylation site [posttranslational modification]
1266845000370	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266845000371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845000372	active site
1266845000373	phosphorylation site [posttranslational modification]
1266845000374	intermolecular recognition site; other site
1266845000375	dimerization interface [polypeptide binding]; other site
1266845000376	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266845000377	DNA binding site [nucleotide binding]
1266845000378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1266845000379	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1266845000380	dimerization interface [polypeptide binding]; other site
1266845000381	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1266845000382	putative active site [active]
1266845000383	heme pocket [chemical binding]; other site
1266845000384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266845000385	dimer interface [polypeptide binding]; other site
1266845000386	phosphorylation site [posttranslational modification]
1266845000387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845000388	ATP binding site [chemical binding]; other site
1266845000389	Mg2+ binding site [ion binding]; other site
1266845000390	G-X-G motif; other site
1266845000391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
1266845000392	YycH protein; Region: YycH; pfam07435
1266845000393	YycH protein; Region: YycI; pfam09648
1266845000394	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1266845000395	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1266845000396	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1266845000397	protein binding site [polypeptide binding]; other site
1266845000398	YyzF-like protein; Region: YyzF; pfam14116
1266845000399	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1266845000400	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1266845000401	dimer interface [polypeptide binding]; other site
1266845000402	active site
1266845000403	metal binding site [ion binding]; metal-binding site
1266845000404	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845000405	glutathione binding site [chemical binding]; other site
1266845000406	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
1266845000407	putative S-transferase; Provisional; Region: PRK11752
1266845000408	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1266845000409	C-terminal domain interface [polypeptide binding]; other site
1266845000410	GSH binding site (G-site) [chemical binding]; other site
1266845000411	dimer interface [polypeptide binding]; other site
1266845000412	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1266845000413	dimer interface [polypeptide binding]; other site
1266845000414	N-terminal domain interface [polypeptide binding]; other site
1266845000415	active site
1266845000416	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1266845000417	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
1266845000418	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
1266845000419	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
1266845000420	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
1266845000421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1266845000422	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1266845000423	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1266845000424	active site
1266845000425	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1266845000426	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1266845000427	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
1266845000428	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
1266845000429	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
1266845000430	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
1266845000431	nudix motif; other site
1266845000432	uracil transporter; Provisional; Region: PRK10720
1266845000433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1266845000434	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1266845000435	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1266845000436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1266845000437	Domain of unknown function (DUF1846); Region: DUF1846; pfam08903
1266845000438	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1266845000439	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1266845000440	NlpC/P60 family; Region: NLPC_P60; pfam00877
1266845000441	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1266845000442	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1266845000443	peptide binding site [polypeptide binding]; other site
1266845000444	glycerol kinase; Provisional; Region: glpK; PRK00047
1266845000445	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1266845000446	N- and C-terminal domain interface [polypeptide binding]; other site
1266845000447	active site
1266845000448	MgATP binding site [chemical binding]; other site
1266845000449	catalytic site [active]
1266845000450	metal binding site [ion binding]; metal-binding site
1266845000451	glycerol binding site [chemical binding]; other site
1266845000452	homotetramer interface [polypeptide binding]; other site
1266845000453	homodimer interface [polypeptide binding]; other site
1266845000454	FBP binding site [chemical binding]; other site
1266845000455	protein IIAGlc interface [polypeptide binding]; other site
1266845000456	glycerol kinase; Provisional; Region: glpK; PRK00047
1266845000457	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1266845000458	N- and C-terminal domain interface [polypeptide binding]; other site
1266845000459	active site
1266845000460	MgATP binding site [chemical binding]; other site
1266845000461	catalytic site [active]
1266845000462	metal binding site [ion binding]; metal-binding site
1266845000463	glycerol binding site [chemical binding]; other site
1266845000464	homotetramer interface [polypeptide binding]; other site
1266845000465	homodimer interface [polypeptide binding]; other site
1266845000466	FBP binding site [chemical binding]; other site
1266845000467	protein IIAGlc interface [polypeptide binding]; other site
1266845000468	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1266845000469	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
1266845000470	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1266845000471	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1266845000472	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1266845000473	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
1266845000474	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1266845000475	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266845000476	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266845000477	ABC transporter; Region: ABC_tran_2; pfam12848
1266845000478	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266845000479	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1266845000480	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1266845000481	Haemolytic domain; Region: Haemolytic; pfam01809
1266845000482	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1266845000483	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1266845000484	active site
1266845000485	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1266845000486	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1266845000487	NAD(P) binding site [chemical binding]; other site
1266845000488	putative active site [active]
1266845000489	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1266845000490	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1266845000491	NAD binding site [chemical binding]; other site
1266845000492	catalytic Zn binding site [ion binding]; other site
1266845000493	structural Zn binding site [ion binding]; other site
1266845000494	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1266845000495	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1266845000496	active site
1266845000497	HIGH motif; other site
1266845000498	dimer interface [polypeptide binding]; other site
1266845000499	KMSKS motif; other site
1266845000500	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266845000501	RNA binding surface [nucleotide binding]; other site
1266845000502	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845000503	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1266845000504	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1266845000505	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266845000506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845000507	non-specific DNA binding site [nucleotide binding]; other site
1266845000508	salt bridge; other site
1266845000509	sequence-specific DNA binding site [nucleotide binding]; other site
1266845000510	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266845000511	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845000512	non-specific DNA binding site [nucleotide binding]; other site
1266845000513	salt bridge; other site
1266845000514	sequence-specific DNA binding site [nucleotide binding]; other site
1266845000515	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1266845000516	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1266845000517	glycerate kinase; Region: TIGR00045
1266845000518	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1266845000519	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1266845000520	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1266845000521	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1266845000522	nudix motif; other site
1266845000523	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266845000524	dimerization interface [polypeptide binding]; other site
1266845000525	putative DNA binding site [nucleotide binding]; other site
1266845000526	putative Zn2+ binding site [ion binding]; other site
1266845000527	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1266845000528	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266845000529	metal-binding site [ion binding]
1266845000530	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266845000531	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1266845000532	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1266845000533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266845000534	Coenzyme A binding pocket [chemical binding]; other site
1266845000535	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1266845000536	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1266845000537	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1266845000538	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1266845000539	Walker A/P-loop; other site
1266845000540	ATP binding site [chemical binding]; other site
1266845000541	Q-loop/lid; other site
1266845000542	ABC transporter signature motif; other site
1266845000543	Walker B; other site
1266845000544	D-loop; other site
1266845000545	H-loop/switch region; other site
1266845000546	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
1266845000547	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1266845000548	substrate binding pocket [chemical binding]; other site
1266845000549	membrane-bound complex binding site; other site
1266845000550	hinge residues; other site
1266845000551	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845000552	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845000553	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1266845000554	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1266845000555	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1266845000556	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845000557	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1266845000558	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1266845000559	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1266845000560	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1266845000561	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1266845000562	putative acetyltransferase; Provisional; Region: PRK03624
1266845000563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266845000564	Coenzyme A binding pocket [chemical binding]; other site
1266845000565	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1266845000566	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1266845000567	active site
1266845000568	metal binding site [ion binding]; metal-binding site
1266845000569	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1266845000570	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1266845000571	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266845000572	active site
1266845000573	motif I; other site
1266845000574	motif II; other site
1266845000575	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266845000576	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
1266845000577	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1266845000578	tetramer interfaces [polypeptide binding]; other site
1266845000579	binuclear metal-binding site [ion binding]; other site
1266845000580	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1266845000581	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266845000582	Divergent PAP2 family; Region: DUF212; pfam02681
1266845000583	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1266845000584	active site
1266845000585	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1266845000586	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266845000587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266845000588	homodimer interface [polypeptide binding]; other site
1266845000589	catalytic residue [active]
1266845000590	general stress protein 13; Validated; Region: PRK08059
1266845000591	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1266845000592	RNA binding site [nucleotide binding]; other site
1266845000593	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1266845000594	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1266845000595	active site
1266845000596	dimer interface [polypeptide binding]; other site
1266845000597	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1266845000598	dimer interface [polypeptide binding]; other site
1266845000599	active site
1266845000600	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1266845000601	Coenzyme A binding pocket [chemical binding]; other site
1266845000602	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1266845000603	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1266845000604	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1266845000605	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1266845000606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1266845000607	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1266845000608	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1266845000609	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1266845000610	active site
1266845000611	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000612	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1266845000613	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000614	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000615	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000616	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000617	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000618	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000619	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000620	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000621	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1266845000622	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000623	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1266845000624	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845000625	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1266845000626	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845000627	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1266845000628	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1266845000629	HIGH motif; other site
1266845000630	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1266845000631	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1266845000632	active site
1266845000633	KMSKS motif; other site
1266845000634	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1266845000635	tRNA binding surface [nucleotide binding]; other site
1266845000636	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1266845000637	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1266845000638	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1266845000639	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266845000640	RNA binding surface [nucleotide binding]; other site
1266845000641	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1266845000642	active site
1266845000643	uracil binding [chemical binding]; other site
1266845000644	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1266845000645	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1266845000646	substrate binding site [chemical binding]; other site
1266845000647	dimer interface [polypeptide binding]; other site
1266845000648	ATP binding site [chemical binding]; other site
1266845000649	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1266845000650	putative substrate binding site [chemical binding]; other site
1266845000651	putative ATP binding site [chemical binding]; other site
1266845000652	dipeptidase PepV; Reviewed; Region: PRK07318
1266845000653	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1266845000654	active site
1266845000655	metal binding site [ion binding]; metal-binding site
1266845000656	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1266845000657	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1266845000658	putative NAD(P) binding site [chemical binding]; other site
1266845000659	putative active site [active]
1266845000660	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1266845000661	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845000662	active site
1266845000663	Protein of unknown function (DUF975); Region: DUF975; pfam06161
1266845000664	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
1266845000665	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1266845000666	putative Cl- selectivity filter; other site
1266845000667	putative pore gating glutamate residue; other site
1266845000668	Thioredoxin; Region: Thioredoxin_5; pfam13743
1266845000669	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1266845000670	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1266845000671	dimer interface [polypeptide binding]; other site
1266845000672	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266845000673	catalytic residue [active]
1266845000674	cystathionine beta-lyase; Provisional; Region: PRK07671
1266845000675	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1266845000676	homodimer interface [polypeptide binding]; other site
1266845000677	substrate-cofactor binding pocket; other site
1266845000678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266845000679	catalytic residue [active]
1266845000680	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1266845000681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266845000682	S-adenosylmethionine binding site [chemical binding]; other site
1266845000683	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1266845000684	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1266845000685	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1266845000686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266845000687	dimer interface [polypeptide binding]; other site
1266845000688	conserved gate region; other site
1266845000689	putative PBP binding loops; other site
1266845000690	ABC-ATPase subunit interface; other site
1266845000691	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1266845000692	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1266845000693	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1266845000694	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1266845000695	Tubby C 2; Region: Tub_2; cl02043
1266845000696	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
1266845000697	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
1266845000698	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266845000699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845000700	putative substrate translocation pore; other site
1266845000701	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266845000702	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266845000703	active site
1266845000704	catalytic tetrad [active]
1266845000705	AAA domain; Region: AAA_17; pfam13207
1266845000706	AAA domain; Region: AAA_18; pfam13238
1266845000707	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1266845000708	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1266845000709	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1266845000710	dimer interface [polypeptide binding]; other site
1266845000711	pyridoxal binding site [chemical binding]; other site
1266845000712	ATP binding site [chemical binding]; other site
1266845000713	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1266845000714	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1266845000715	putative NAD(P) binding site [chemical binding]; other site
1266845000716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1266845000717	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1266845000718	Peptidase family M23; Region: Peptidase_M23; pfam01551
1266845000719	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1266845000720	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1266845000721	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1266845000722	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1266845000723	Zn2+ binding site [ion binding]; other site
1266845000724	Mg2+ binding site [ion binding]; other site
1266845000725	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1266845000726	active site
1266845000727	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1266845000728	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266845000729	Coenzyme A binding pocket [chemical binding]; other site
1266845000730	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
1266845000731	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
1266845000732	teramer interface [polypeptide binding]; other site
1266845000733	active site
1266845000734	FMN binding site [chemical binding]; other site
1266845000735	catalytic residues [active]
1266845000736	Predicted transcriptional regulators [Transcription]; Region: COG1733
1266845000737	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266845000738	dimerization interface [polypeptide binding]; other site
1266845000739	putative DNA binding site [nucleotide binding]; other site
1266845000740	putative Zn2+ binding site [ion binding]; other site
1266845000741	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845000742	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1266845000743	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1266845000744	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1266845000745	dimer interface [polypeptide binding]; other site
1266845000746	motif 1; other site
1266845000747	active site
1266845000748	motif 2; other site
1266845000749	motif 3; other site
1266845000750	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1266845000751	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1266845000752	putative tRNA-binding site [nucleotide binding]; other site
1266845000753	B3/4 domain; Region: B3_4; pfam03483
1266845000754	tRNA synthetase B5 domain; Region: B5; smart00874
1266845000755	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1266845000756	dimer interface [polypeptide binding]; other site
1266845000757	motif 1; other site
1266845000758	motif 3; other site
1266845000759	motif 2; other site
1266845000760	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1266845000761	L-type amino acid transporter; Region: 2A0308; TIGR00911
1266845000762	ribonuclease HIII; Provisional; Region: PRK00996
1266845000763	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1266845000764	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1266845000765	RNA/DNA hybrid binding site [nucleotide binding]; other site
1266845000766	active site
1266845000767	Cell division protein ZapA; Region: ZapA; pfam05164
1266845000768	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1266845000769	Colicin V production protein; Region: Colicin_V; pfam02674
1266845000770	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1266845000771	MutS domain III; Region: MutS_III; pfam05192
1266845000772	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1266845000773	Walker A/P-loop; other site
1266845000774	ATP binding site [chemical binding]; other site
1266845000775	Q-loop/lid; other site
1266845000776	ABC transporter signature motif; other site
1266845000777	Walker B; other site
1266845000778	D-loop; other site
1266845000779	H-loop/switch region; other site
1266845000780	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1266845000781	Smr domain; Region: Smr; pfam01713
1266845000782	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1266845000783	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1266845000784	catalytic residues [active]
1266845000785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845000786	non-specific DNA binding site [nucleotide binding]; other site
1266845000787	salt bridge; other site
1266845000788	sequence-specific DNA binding site [nucleotide binding]; other site
1266845000789	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266845000790	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1266845000791	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1266845000792	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1266845000793	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1266845000794	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
1266845000795	Heat induced stress protein YflT; Region: YflT; pfam11181
1266845000796	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1266845000797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845000798	Walker A/P-loop; other site
1266845000799	ATP binding site [chemical binding]; other site
1266845000800	Q-loop/lid; other site
1266845000801	ABC transporter signature motif; other site
1266845000802	Walker B; other site
1266845000803	D-loop; other site
1266845000804	H-loop/switch region; other site
1266845000805	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1266845000806	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1266845000807	glutamate racemase; Provisional; Region: PRK00865
1266845000808	ribonuclease PH; Reviewed; Region: rph; PRK00173
1266845000809	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1266845000810	hexamer interface [polypeptide binding]; other site
1266845000811	active site
1266845000812	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1266845000813	active site
1266845000814	dimerization interface [polypeptide binding]; other site
1266845000815	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1266845000816	active site
1266845000817	metal binding site [ion binding]; metal-binding site
1266845000818	homotetramer interface [polypeptide binding]; other site
1266845000819	FOG: CBS domain [General function prediction only]; Region: COG0517
1266845000820	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1266845000821	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1266845000822	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1266845000823	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1266845000824	trimer interface [polypeptide binding]; other site
1266845000825	active site
1266845000826	substrate binding site [chemical binding]; other site
1266845000827	CoA binding site [chemical binding]; other site
1266845000828	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1266845000829	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1266845000830	metal binding site [ion binding]; metal-binding site
1266845000831	putative dimer interface [polypeptide binding]; other site
1266845000832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845000833	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266845000834	putative substrate translocation pore; other site
1266845000835	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1266845000836	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1266845000837	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266845000838	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1266845000839	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1266845000840	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
1266845000841	YtxH-like protein; Region: YtxH; pfam12732
1266845000842	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1266845000843	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1266845000844	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1266845000845	active site
1266845000846	catabolite control protein A; Region: ccpA; TIGR01481
1266845000847	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1266845000848	DNA binding site [nucleotide binding]
1266845000849	domain linker motif; other site
1266845000850	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1266845000851	dimerization interface [polypeptide binding]; other site
1266845000852	effector binding site; other site
1266845000853	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1266845000854	Transglycosylase; Region: Transgly; pfam00912
1266845000855	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1266845000856	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1266845000857	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1266845000858	zinc binding site [ion binding]; other site
1266845000859	putative ligand binding site [chemical binding]; other site
1266845000860	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1266845000861	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1266845000862	TM-ABC transporter signature motif; other site
1266845000863	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1266845000864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845000865	Walker A/P-loop; other site
1266845000866	ATP binding site [chemical binding]; other site
1266845000867	Q-loop/lid; other site
1266845000868	ABC transporter signature motif; other site
1266845000869	Walker B; other site
1266845000870	D-loop; other site
1266845000871	H-loop/switch region; other site
1266845000872	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1266845000873	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1266845000874	active site residue [active]
1266845000875	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1266845000876	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1266845000877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1266845000878	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1266845000879	NlpC/P60 family; Region: NLPC_P60; pfam00877
1266845000880	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1266845000881	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1266845000882	Ca binding site [ion binding]; other site
1266845000883	active site
1266845000884	catalytic site [active]
1266845000885	short chain dehydrogenase; Provisional; Region: PRK06701
1266845000886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266845000887	NAD(P) binding site [chemical binding]; other site
1266845000888	active site
1266845000889	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1266845000890	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1266845000891	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1266845000892	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1266845000893	active site
1266845000894	Zn binding site [ion binding]; other site
1266845000895	Predicted integral membrane protein [Function unknown]; Region: COG5652
1266845000896	hypothetical protein; Validated; Region: PRK00110
1266845000897	Type II/IV secretion system protein; Region: T2SE; pfam00437
1266845000898	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1266845000899	Walker A motif; other site
1266845000900	ATP binding site [chemical binding]; other site
1266845000901	Walker B motif; other site
1266845000902	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1266845000903	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1266845000904	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1266845000905	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1266845000906	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1266845000907	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1266845000908	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1266845000909	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1266845000910	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1266845000911	ComG operon protein 7; Region: ComGG; pfam14173
1266845000912	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1266845000913	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1266845000914	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1266845000915	active site
1266845000916	elongation factor P; Validated; Region: PRK00529
1266845000917	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1266845000918	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1266845000919	RNA binding site [nucleotide binding]; other site
1266845000920	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1266845000921	RNA binding site [nucleotide binding]; other site
1266845000922	Asp23 family; Region: Asp23; pfam03780
1266845000923	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1266845000924	putative RNA binding site [nucleotide binding]; other site
1266845000925	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
1266845000926	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1266845000927	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1266845000928	homodimer interface [polypeptide binding]; other site
1266845000929	NADP binding site [chemical binding]; other site
1266845000930	substrate binding site [chemical binding]; other site
1266845000931	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1266845000932	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1266845000933	generic binding surface II; other site
1266845000934	generic binding surface I; other site
1266845000935	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1266845000936	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1266845000937	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1266845000938	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1266845000939	substrate binding pocket [chemical binding]; other site
1266845000940	chain length determination region; other site
1266845000941	substrate-Mg2+ binding site; other site
1266845000942	catalytic residues [active]
1266845000943	aspartate-rich region 1; other site
1266845000944	active site lid residues [active]
1266845000945	aspartate-rich region 2; other site
1266845000946	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1266845000947	S4 RNA-binding domain; Region: S4; smart00363
1266845000948	RNA binding surface [nucleotide binding]; other site
1266845000949	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1266845000950	Arginine repressor [Transcription]; Region: ArgR; COG1438
1266845000951	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1266845000952	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1266845000953	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1266845000954	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1266845000955	Walker A/P-loop; other site
1266845000956	ATP binding site [chemical binding]; other site
1266845000957	Q-loop/lid; other site
1266845000958	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1266845000959	ABC transporter signature motif; other site
1266845000960	Walker B; other site
1266845000961	D-loop; other site
1266845000962	H-loop/switch region; other site
1266845000963	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1266845000964	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
1266845000965	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1266845000966	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1266845000967	Cl binding site [ion binding]; other site
1266845000968	oligomer interface [polypeptide binding]; other site
1266845000969	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1266845000970	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1266845000971	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1266845000972	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266845000973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845000974	active site
1266845000975	phosphorylation site [posttranslational modification]
1266845000976	intermolecular recognition site; other site
1266845000977	dimerization interface [polypeptide binding]; other site
1266845000978	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266845000979	DNA binding site [nucleotide binding]
1266845000980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266845000981	HAMP domain; Region: HAMP; pfam00672
1266845000982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266845000983	dimer interface [polypeptide binding]; other site
1266845000984	phosphorylation site [posttranslational modification]
1266845000985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845000986	ATP binding site [chemical binding]; other site
1266845000987	Mg2+ binding site [ion binding]; other site
1266845000988	G-X-G motif; other site
1266845000989	OxaA-like protein precursor; Provisional; Region: PRK02463
1266845000990	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1266845000991	Acylphosphatase; Region: Acylphosphatase; pfam00708
1266845000992	DNA topoisomerase III; Provisional; Region: PRK07726
1266845000993	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1266845000994	active site
1266845000995	putative interdomain interaction site [polypeptide binding]; other site
1266845000996	putative metal-binding site [ion binding]; other site
1266845000997	putative nucleotide binding site [chemical binding]; other site
1266845000998	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1266845000999	domain I; other site
1266845001000	DNA binding groove [nucleotide binding]
1266845001001	phosphate binding site [ion binding]; other site
1266845001002	domain II; other site
1266845001003	domain III; other site
1266845001004	nucleotide binding site [chemical binding]; other site
1266845001005	catalytic site [active]
1266845001006	domain IV; other site
1266845001007	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1266845001008	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001009	ribosomal protein L20 leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001010	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
1266845001011	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001012	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001013	cspA; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001014	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266845001015	DNA-binding site [nucleotide binding]; DNA binding site
1266845001016	RNA-binding motif; other site
1266845001017	cspA; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001018	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266845001019	DNA-binding site [nucleotide binding]; DNA binding site
1266845001020	RNA-binding motif; other site
1266845001021	cspA; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001022	cspA; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001023	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001024	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1266845001025	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1266845001026	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1266845001027	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001028	SEC-C motif; Region: SEC-C; pfam02810
1266845001029	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1266845001030	16S/18S rRNA binding site [nucleotide binding]; other site
1266845001031	S13e-L30e interaction site [polypeptide binding]; other site
1266845001032	25S rRNA binding site [nucleotide binding]; other site
1266845001033	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1266845001034	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1266845001035	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1266845001036	active site turn [active]
1266845001037	phosphorylation site [posttranslational modification]
1266845001038	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1266845001039	active site turn [active]
1266845001040	phosphorylation site [posttranslational modification]
1266845001041	putative DNA-binding protein; Validated; Region: PRK00118
1266845001042	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1266845001043	signal recognition particle protein; Provisional; Region: PRK10867
1266845001044	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1266845001045	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1266845001046	P loop; other site
1266845001047	GTP binding site [chemical binding]; other site
1266845001048	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1266845001049	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1266845001050	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1266845001051	KH domain; Region: KH_4; pfam13083
1266845001052	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1266845001053	RimM N-terminal domain; Region: RimM; pfam01782
1266845001054	PRC-barrel domain; Region: PRC; pfam05239
1266845001055	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1266845001056	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1266845001057	OsmC-like protein; Region: OsmC; pfam02566
1266845001058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1266845001059	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1266845001060	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1266845001061	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1266845001062	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1266845001063	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1266845001064	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1266845001065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266845001066	active site
1266845001067	motif I; other site
1266845001068	motif II; other site
1266845001069	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1266845001070	esterase; Provisional; Region: PRK10566
1266845001071	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1266845001072	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1266845001073	Clp amino terminal domain; Region: Clp_N; pfam02861
1266845001074	Clp amino terminal domain; Region: Clp_N; pfam02861
1266845001075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266845001076	Walker A motif; other site
1266845001077	ATP binding site [chemical binding]; other site
1266845001078	Walker B motif; other site
1266845001079	arginine finger; other site
1266845001080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266845001081	Walker A motif; other site
1266845001082	ATP binding site [chemical binding]; other site
1266845001083	Walker B motif; other site
1266845001084	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1266845001085	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1266845001086	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1266845001087	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1266845001088	active site
1266845001089	PHP Thumb interface [polypeptide binding]; other site
1266845001090	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1266845001091	generic binding surface II; other site
1266845001092	generic binding surface I; other site
1266845001093	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1266845001094	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1266845001095	active site
1266845001096	ADP/pyrophosphate binding site [chemical binding]; other site
1266845001097	dimerization interface [polypeptide binding]; other site
1266845001098	allosteric effector site; other site
1266845001099	fructose-1,6-bisphosphate binding site; other site
1266845001100	pyruvate kinase; Provisional; Region: PRK06354
1266845001101	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1266845001102	domain interfaces; other site
1266845001103	active site
1266845001104	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1266845001105	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1266845001106	S1 domain; Region: S1_2; pfam13509
1266845001107	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1266845001108	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1266845001109	active site
1266845001110	Int/Topo IB signature motif; other site
1266845001111	phosphopentomutase; Provisional; Region: PRK05362
1266845001112	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1266845001113	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1266845001114	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1266845001115	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1266845001116	active site
1266845001117	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1266845001118	substrate binding site [chemical binding]; other site
1266845001119	catalytic residues [active]
1266845001120	dimer interface [polypeptide binding]; other site
1266845001121	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1266845001122	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1266845001123	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1266845001124	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1266845001125	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266845001126	RNA binding surface [nucleotide binding]; other site
1266845001127	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1266845001128	active site
1266845001129	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266845001130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845001131	active site
1266845001132	phosphorylation site [posttranslational modification]
1266845001133	intermolecular recognition site; other site
1266845001134	dimerization interface [polypeptide binding]; other site
1266845001135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266845001136	DNA binding site [nucleotide binding]
1266845001137	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1266845001138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1266845001139	dimerization interface [polypeptide binding]; other site
1266845001140	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266845001141	dimer interface [polypeptide binding]; other site
1266845001142	phosphorylation site [posttranslational modification]
1266845001143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845001144	ATP binding site [chemical binding]; other site
1266845001145	Mg2+ binding site [ion binding]; other site
1266845001146	G-X-G motif; other site
1266845001147	Predicted membrane protein [Function unknown]; Region: COG3601
1266845001148	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1266845001149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1266845001150	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1266845001151	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266845001152	ATP binding site [chemical binding]; other site
1266845001153	putative Mg++ binding site [ion binding]; other site
1266845001154	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266845001155	nucleotide binding region [chemical binding]; other site
1266845001156	ATP-binding site [chemical binding]; other site
1266845001157	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845001158	cytidylate kinase; Provisional; Region: cmk; PRK00023
1266845001159	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1266845001160	CMP-binding site; other site
1266845001161	The sites determining sugar specificity; other site
1266845001162	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1266845001163	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1266845001164	RNA binding site [nucleotide binding]; other site
1266845001165	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1266845001166	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1266845001167	RNA binding site [nucleotide binding]; other site
1266845001168	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1266845001169	RNA binding site [nucleotide binding]; other site
1266845001170	GTP-binding protein Der; Reviewed; Region: PRK00093
1266845001171	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1266845001172	G1 box; other site
1266845001173	GTP/Mg2+ binding site [chemical binding]; other site
1266845001174	Switch I region; other site
1266845001175	G2 box; other site
1266845001176	Switch II region; other site
1266845001177	G3 box; other site
1266845001178	G4 box; other site
1266845001179	G5 box; other site
1266845001180	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1266845001181	G1 box; other site
1266845001182	GTP/Mg2+ binding site [chemical binding]; other site
1266845001183	Switch I region; other site
1266845001184	G2 box; other site
1266845001185	G3 box; other site
1266845001186	Switch II region; other site
1266845001187	G4 box; other site
1266845001188	G5 box; other site
1266845001189	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1266845001190	IHF dimer interface [polypeptide binding]; other site
1266845001191	IHF - DNA interface [nucleotide binding]; other site
1266845001192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1266845001193	binding surface
1266845001194	TPR motif; other site
1266845001195	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266845001196	TPR motif; other site
1266845001197	binding surface
1266845001198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266845001199	binding surface
1266845001200	TPR motif; other site
1266845001201	hypothetical protein; Provisional; Region: PRK03636
1266845001202	UPF0302 domain; Region: UPF0302; pfam08864
1266845001203	IDEAL domain; Region: IDEAL; cl07452
1266845001204	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1266845001205	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1266845001206	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1266845001207	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1266845001208	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1266845001209	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1266845001210	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1266845001211	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1266845001212	active site
1266845001213	NTP binding site [chemical binding]; other site
1266845001214	metal binding triad [ion binding]; metal-binding site
1266845001215	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1266845001216	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1266845001217	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1266845001218	dimer interface [polypeptide binding]; other site
1266845001219	FMN binding site [chemical binding]; other site
1266845001220	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1266845001221	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1266845001222	active site
1266845001223	catalytic site [active]
1266845001224	substrate binding site [chemical binding]; other site
1266845001225	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1266845001226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1266845001227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266845001228	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1266845001229	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1266845001230	putative dimer interface [polypeptide binding]; other site
1266845001231	putative anticodon binding site; other site
1266845001232	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1266845001233	homodimer interface [polypeptide binding]; other site
1266845001234	motif 1; other site
1266845001235	motif 2; other site
1266845001236	active site
1266845001237	motif 3; other site
1266845001238	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1266845001239	Helix-turn-helix domain; Region: HTH_36; pfam13730
1266845001240	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1266845001241	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1266845001242	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1266845001243	minor groove reading motif; other site
1266845001244	helix-hairpin-helix signature motif; other site
1266845001245	substrate binding pocket [chemical binding]; other site
1266845001246	active site
1266845001247	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1266845001248	Transglycosylase; Region: Transgly; pfam00912
1266845001249	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1266845001250	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1266845001251	hypothetical protein; Provisional; Region: PRK13660
1266845001252	cell division protein GpsB; Provisional; Region: PRK14127
1266845001253	DivIVA domain; Region: DivI1A_domain; TIGR03544
1266845001254	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1266845001255	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1266845001256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1266845001257	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1266845001258	RNA/DNA hybrid binding site [nucleotide binding]; other site
1266845001259	active site
1266845001260	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266845001261	DNA-binding site [nucleotide binding]; DNA binding site
1266845001262	RNA-binding motif; other site
1266845001263	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1266845001264	Fe-S cluster binding site [ion binding]; other site
1266845001265	active site
1266845001266	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1266845001267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845001268	Walker A/P-loop; other site
1266845001269	ATP binding site [chemical binding]; other site
1266845001270	Q-loop/lid; other site
1266845001271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266845001272	ABC transporter signature motif; other site
1266845001273	Walker B; other site
1266845001274	D-loop; other site
1266845001275	ABC transporter; Region: ABC_tran_2; pfam12848
1266845001276	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266845001277	thymidylate synthase; Region: thym_sym; TIGR03284
1266845001278	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1266845001279	dimerization interface [polypeptide binding]; other site
1266845001280	active site
1266845001281	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1266845001282	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1266845001283	folate binding site [chemical binding]; other site
1266845001284	NADP+ binding site [chemical binding]; other site
1266845001285	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1266845001286	active site
1266845001287	catalytic triad [active]
1266845001288	oxyanion hole [active]
1266845001289	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
1266845001290	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1266845001291	hypothetical protein; Provisional; Region: PRK13672
1266845001292	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1266845001293	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1266845001294	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1266845001295	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1266845001296	Catalytic site [active]
1266845001297	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1266845001298	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1266845001299	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1266845001300	GTP/Mg2+ binding site [chemical binding]; other site
1266845001301	G4 box; other site
1266845001302	G5 box; other site
1266845001303	G1 box; other site
1266845001304	Switch I region; other site
1266845001305	G2 box; other site
1266845001306	G3 box; other site
1266845001307	Switch II region; other site
1266845001308	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1266845001309	RNA/DNA hybrid binding site [nucleotide binding]; other site
1266845001310	active site
1266845001311	LexA repressor; Validated; Region: PRK00215
1266845001312	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1266845001313	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1266845001314	Catalytic site [active]
1266845001315	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
1266845001316	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1266845001317	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1266845001318	TPP-binding site [chemical binding]; other site
1266845001319	dimer interface [polypeptide binding]; other site
1266845001320	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1266845001321	PYR/PP interface [polypeptide binding]; other site
1266845001322	dimer interface [polypeptide binding]; other site
1266845001323	TPP binding site [chemical binding]; other site
1266845001324	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266845001325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1266845001326	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845001327	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1266845001328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845001329	Walker A/P-loop; other site
1266845001330	ATP binding site [chemical binding]; other site
1266845001331	Q-loop/lid; other site
1266845001332	ABC transporter signature motif; other site
1266845001333	Walker B; other site
1266845001334	D-loop; other site
1266845001335	H-loop/switch region; other site
1266845001336	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845001337	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845001338	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1266845001339	Walker A/P-loop; other site
1266845001340	ATP binding site [chemical binding]; other site
1266845001341	Q-loop/lid; other site
1266845001342	ABC transporter signature motif; other site
1266845001343	Walker B; other site
1266845001344	D-loop; other site
1266845001345	H-loop/switch region; other site
1266845001346	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1266845001347	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1266845001348	putative acyl-acceptor binding pocket; other site
1266845001349	SWIM zinc finger; Region: SWIM; pfam04434
1266845001350	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1266845001351	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1266845001352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266845001353	ATP binding site [chemical binding]; other site
1266845001354	putative Mg++ binding site [ion binding]; other site
1266845001355	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266845001356	nucleotide binding region [chemical binding]; other site
1266845001357	ATP-binding site [chemical binding]; other site
1266845001358	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1266845001359	rRNA interaction site [nucleotide binding]; other site
1266845001360	S8 interaction site; other site
1266845001361	putative laminin-1 binding site; other site
1266845001362	elongation factor Ts; Provisional; Region: tsf; PRK09377
1266845001363	Elongation factor TS; Region: EF_TS; pfam00889
1266845001364	Elongation factor TS; Region: EF_TS; pfam00889
1266845001365	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1266845001366	putative nucleotide binding site [chemical binding]; other site
1266845001367	uridine monophosphate binding site [chemical binding]; other site
1266845001368	homohexameric interface [polypeptide binding]; other site
1266845001369	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1266845001370	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1266845001371	hinge region; other site
1266845001372	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1266845001373	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1266845001374	catalytic residue [active]
1266845001375	putative FPP diphosphate  binding site; other site
1266845001376	putative FPP binding hydrophobic cleft; other site
1266845001377	dimer interface [polypeptide binding]; other site
1266845001378	putative IPP diphosphate binding site; other site
1266845001379	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1266845001380	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1266845001381	RIP metalloprotease RseP; Region: TIGR00054
1266845001382	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1266845001383	active site
1266845001384	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1266845001385	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1266845001386	protein binding site [polypeptide binding]; other site
1266845001387	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1266845001388	putative substrate binding region [chemical binding]; other site
1266845001389	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1266845001390	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1266845001391	dimer interface [polypeptide binding]; other site
1266845001392	motif 1; other site
1266845001393	active site
1266845001394	motif 2; other site
1266845001395	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1266845001396	putative deacylase active site [active]
1266845001397	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1266845001398	active site
1266845001399	motif 3; other site
1266845001400	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1266845001401	anticodon binding site; other site
1266845001402	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1266845001403	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1266845001404	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1266845001405	generic binding surface II; other site
1266845001406	generic binding surface I; other site
1266845001407	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1266845001408	active site
1266845001409	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1266845001410	active site
1266845001411	catalytic site [active]
1266845001412	substrate binding site [chemical binding]; other site
1266845001413	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1266845001414	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1266845001415	Sm and related proteins; Region: Sm_like; cl00259
1266845001416	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1266845001417	putative oligomer interface [polypeptide binding]; other site
1266845001418	putative RNA binding site [nucleotide binding]; other site
1266845001419	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1266845001420	NusA N-terminal domain; Region: NusA_N; pfam08529
1266845001421	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1266845001422	RNA binding site [nucleotide binding]; other site
1266845001423	homodimer interface [polypeptide binding]; other site
1266845001424	NusA-like KH domain; Region: KH_5; pfam13184
1266845001425	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1266845001426	G-X-X-G motif; other site
1266845001427	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1266845001428	putative RNA binding cleft [nucleotide binding]; other site
1266845001429	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1266845001430	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1266845001431	translation initiation factor IF-2; Region: IF-2; TIGR00487
1266845001432	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1266845001433	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1266845001434	G1 box; other site
1266845001435	putative GEF interaction site [polypeptide binding]; other site
1266845001436	GTP/Mg2+ binding site [chemical binding]; other site
1266845001437	Switch I region; other site
1266845001438	G2 box; other site
1266845001439	G3 box; other site
1266845001440	Switch II region; other site
1266845001441	G4 box; other site
1266845001442	G5 box; other site
1266845001443	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1266845001444	Translation-initiation factor 2; Region: IF-2; pfam11987
1266845001445	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1266845001446	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1266845001447	Predicted membrane protein [Function unknown]; Region: COG2323
1266845001448	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1266845001449	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1266845001450	RNA binding site [nucleotide binding]; other site
1266845001451	active site
1266845001452	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1266845001453	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1266845001454	active site
1266845001455	Riboflavin kinase; Region: Flavokinase; smart00904
1266845001456	argininosuccinate synthase; Provisional; Region: PRK13820
1266845001457	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1266845001458	ANP binding site [chemical binding]; other site
1266845001459	Substrate Binding Site II [chemical binding]; other site
1266845001460	Substrate Binding Site I [chemical binding]; other site
1266845001461	argininosuccinate lyase; Provisional; Region: PRK00855
1266845001462	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1266845001463	active sites [active]
1266845001464	tetramer interface [polypeptide binding]; other site
1266845001465	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1266845001466	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1266845001467	GrpE; Region: GrpE; pfam01025
1266845001468	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1266845001469	dimer interface [polypeptide binding]; other site
1266845001470	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1266845001471	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1266845001472	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1266845001473	nucleotide binding site [chemical binding]; other site
1266845001474	NEF interaction site [polypeptide binding]; other site
1266845001475	SBD interface [polypeptide binding]; other site
1266845001476	chaperone protein DnaJ; Provisional; Region: PRK14276
1266845001477	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1266845001478	HSP70 interaction site [polypeptide binding]; other site
1266845001479	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1266845001480	substrate binding site [polypeptide binding]; other site
1266845001481	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1266845001482	Zn binding sites [ion binding]; other site
1266845001483	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1266845001484	dimer interface [polypeptide binding]; other site
1266845001485	GTP-binding protein LepA; Provisional; Region: PRK05433
1266845001486	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1266845001487	G1 box; other site
1266845001488	putative GEF interaction site [polypeptide binding]; other site
1266845001489	GTP/Mg2+ binding site [chemical binding]; other site
1266845001490	Switch I region; other site
1266845001491	G2 box; other site
1266845001492	G3 box; other site
1266845001493	Switch II region; other site
1266845001494	G4 box; other site
1266845001495	G5 box; other site
1266845001496	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1266845001497	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1266845001498	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1266845001499	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
1266845001500	putative hydrophobic ligand binding site [chemical binding]; other site
1266845001501	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1266845001502	Coenzyme A binding pocket [chemical binding]; other site
1266845001503	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1266845001504	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1266845001505	Coenzyme A binding pocket [chemical binding]; other site
1266845001506	Predicted membrane protein [Function unknown]; Region: COG2855
1266845001507	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266845001508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266845001509	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1266845001510	putative dimerization interface [polypeptide binding]; other site
1266845001511	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1266845001512	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1266845001513	DNA polymerase IV; Reviewed; Region: PRK03103
1266845001514	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1266845001515	active site
1266845001516	DNA binding site [nucleotide binding]
1266845001517	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1266845001518	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266845001519	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1266845001520	Coenzyme A binding pocket [chemical binding]; other site
1266845001521	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1266845001522	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1266845001523	DNA binding residues [nucleotide binding]
1266845001524	putative dimer interface [polypeptide binding]; other site
1266845001525	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266845001526	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266845001527	active site
1266845001528	catalytic tetrad [active]
1266845001529	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266845001530	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266845001531	active site
1266845001532	catalytic tetrad [active]
1266845001533	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845001534	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845001535	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845001536	Walker A/P-loop; other site
1266845001537	ATP binding site [chemical binding]; other site
1266845001538	Q-loop/lid; other site
1266845001539	ABC transporter signature motif; other site
1266845001540	Walker B; other site
1266845001541	D-loop; other site
1266845001542	H-loop/switch region; other site
1266845001543	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845001544	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845001545	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1266845001546	Walker A/P-loop; other site
1266845001547	ATP binding site [chemical binding]; other site
1266845001548	Q-loop/lid; other site
1266845001549	ABC transporter signature motif; other site
1266845001550	Walker B; other site
1266845001551	D-loop; other site
1266845001552	H-loop/switch region; other site
1266845001553	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001554	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1266845001555	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001556	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1266845001557	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1266845001558	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845001559	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266845001560	Coenzyme A binding pocket [chemical binding]; other site
1266845001561	ComK protein; Region: ComK; cl11560
1266845001562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266845001563	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1266845001564	active site
1266845001565	catalytic triad [active]
1266845001566	oxyanion hole [active]
1266845001567	Nuclease-related domain; Region: NERD; pfam08378
1266845001568	conserved hypothetical protein; Region: MJ1255; TIGR00661
1266845001569	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1266845001570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266845001571	transposase/IS protein; Provisional; Region: PRK09183
1266845001572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266845001573	Walker A motif; other site
1266845001574	ATP binding site [chemical binding]; other site
1266845001575	Walker B motif; other site
1266845001576	arginine finger; other site
1266845001577	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1266845001578	Integrase core domain; Region: rve; pfam00665
1266845001579	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1266845001580	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1266845001581	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1266845001582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1266845001583	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1266845001584	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1266845001585	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
1266845001586	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
1266845001587	GDP-Fucose binding site [chemical binding]; other site
1266845001588	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
1266845001589	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
1266845001590	GDP-Fucose binding site [chemical binding]; other site
1266845001591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266845001592	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1266845001593	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1266845001594	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266845001595	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1266845001596	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1266845001597	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1266845001598	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1266845001599	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1266845001600	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1266845001601	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1266845001602	Chain length determinant protein; Region: Wzz; cl15801
1266845001603	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1266845001604	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1266845001605	active site
1266845001606	tetramer interface; other site
1266845001607	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1266845001608	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1266845001609	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1266845001610	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1266845001611	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1266845001612	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845001613	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1266845001614	SH3-like domain; Region: SH3_8; pfam13457
1266845001615	SH3-like domain; Region: SH3_8; pfam13457
1266845001616	SH3-like domain; Region: SH3_8; pfam13457
1266845001617	SH3-like domain; Region: SH3_8; pfam13457
1266845001618	putative glycosyl transferase; Provisional; Region: PRK10073
1266845001619	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845001620	active site
1266845001621	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266845001622	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266845001623	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1266845001624	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845001625	active site
1266845001626	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
1266845001627	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266845001628	putative ADP-binding pocket [chemical binding]; other site
1266845001629	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845001630	active site
1266845001631	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1266845001632	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1266845001633	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1266845001634	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1266845001635	active site
1266845001636	homodimer interface [polypeptide binding]; other site
1266845001637	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1266845001638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845001639	active site
1266845001640	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1266845001641	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1266845001642	putative glycosyl transferase; Provisional; Region: PRK10073
1266845001643	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845001644	active site
1266845001645	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1266845001646	UDP-glucose 4-epimerase; Region: PLN02240
1266845001647	NAD binding site [chemical binding]; other site
1266845001648	homodimer interface [polypeptide binding]; other site
1266845001649	active site
1266845001650	substrate binding site [chemical binding]; other site
1266845001651	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1266845001652	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1266845001653	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1266845001654	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1266845001655	active site
1266845001656	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1266845001657	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1266845001658	active site
1266845001659	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1266845001660	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1266845001661	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266845001662	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1266845001663	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1266845001664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266845001665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266845001666	WHG domain; Region: WHG; pfam13305
1266845001667	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1266845001668	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1266845001669	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1266845001670	RNA binding site [nucleotide binding]; other site
1266845001671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266845001672	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266845001673	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1266845001674	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1266845001675	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1266845001676	Walker A/P-loop; other site
1266845001677	ATP binding site [chemical binding]; other site
1266845001678	Q-loop/lid; other site
1266845001679	ABC transporter signature motif; other site
1266845001680	Walker B; other site
1266845001681	D-loop; other site
1266845001682	H-loop/switch region; other site
1266845001683	Predicted transcriptional regulators [Transcription]; Region: COG1725
1266845001684	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266845001685	DNA-binding site [nucleotide binding]; DNA binding site
1266845001686	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
1266845001687	putative hydrophobic ligand binding site [chemical binding]; other site
1266845001688	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266845001689	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1266845001690	ATP binding site [chemical binding]; other site
1266845001691	putative Mg++ binding site [ion binding]; other site
1266845001692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266845001693	nucleotide binding region [chemical binding]; other site
1266845001694	ATP-binding site [chemical binding]; other site
1266845001695	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1266845001696	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1266845001697	Mga helix-turn-helix domain; Region: Mga; pfam05043
1266845001698	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266845001699	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266845001700	active site
1266845001701	catalytic tetrad [active]
1266845001702	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1266845001703	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1266845001704	putative active site [active]
1266845001705	putative metal binding site [ion binding]; other site
1266845001706	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1266845001707	Catalytic site [active]
1266845001708	putative kinase; Provisional; Region: PRK09954
1266845001709	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1266845001710	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1266845001711	substrate binding site [chemical binding]; other site
1266845001712	ATP binding site [chemical binding]; other site
1266845001713	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1266845001714	Nitrogen regulatory protein P-II; Region: P-II; cl00412
1266845001715	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
1266845001716	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
1266845001717	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1266845001718	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1266845001719	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1266845001720	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1266845001721	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845001722	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1266845001723	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1266845001724	Ligand binding site; other site
1266845001725	metal-binding site
1266845001726	Protein of unknown function (DUF503); Region: DUF503; pfam04456
1266845001727	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1266845001728	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266845001729	RNA binding surface [nucleotide binding]; other site
1266845001730	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1266845001731	active site
1266845001732	uracil binding [chemical binding]; other site
1266845001733	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1266845001734	putative dimer interface [polypeptide binding]; other site
1266845001735	catalytic triad [active]
1266845001736	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1266845001737	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1266845001738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266845001739	S-adenosylmethionine binding site [chemical binding]; other site
1266845001740	putative lipid kinase; Reviewed; Region: PRK13055
1266845001741	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1266845001742	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1266845001743	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1266845001744	GatB domain; Region: GatB_Yqey; smart00845
1266845001745	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1266845001746	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1266845001747	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1266845001748	esterase; Provisional; Region: PRK10566
1266845001749	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1266845001750	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1266845001751	putative dimer interface [polypeptide binding]; other site
1266845001752	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1266845001753	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1266845001754	putative dimer interface [polypeptide binding]; other site
1266845001755	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1266845001756	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1266845001757	nucleotide binding pocket [chemical binding]; other site
1266845001758	K-X-D-G motif; other site
1266845001759	catalytic site [active]
1266845001760	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1266845001761	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1266845001762	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1266845001763	Dimer interface [polypeptide binding]; other site
1266845001764	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1266845001765	Part of AAA domain; Region: AAA_19; pfam13245
1266845001766	Family description; Region: UvrD_C_2; pfam13538
1266845001767	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1266845001768	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266845001769	DNA-binding site [nucleotide binding]; DNA binding site
1266845001770	EamA-like transporter family; Region: EamA; pfam00892
1266845001771	EamA-like transporter family; Region: EamA; cl17759
1266845001772	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1266845001773	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1266845001774	tetramer interface [polypeptide binding]; other site
1266845001775	active site
1266845001776	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1266845001777	ATP-grasp domain; Region: ATP-grasp; pfam02222
1266845001778	hypothetical protein; Provisional; Region: PRK04164
1266845001779	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1266845001780	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266845001781	active site
1266845001782	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1266845001783	Domain of unknown function DUF21; Region: DUF21; pfam01595
1266845001784	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1266845001785	Transporter associated domain; Region: CorC_HlyC; pfam03471
1266845001786	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1266845001787	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1266845001788	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1266845001789	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1266845001790	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1266845001791	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1266845001792	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1266845001793	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1266845001794	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1266845001795	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1266845001796	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1266845001797	Predicted secreted protein [Function unknown]; Region: COG4086
1266845001798	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1266845001799	FOG: CBS domain [General function prediction only]; Region: COG0517
1266845001800	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
1266845001801	FOG: CBS domain [General function prediction only]; Region: COG0517
1266845001802	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1266845001803	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1266845001804	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1266845001805	Walker A/P-loop; other site
1266845001806	ATP binding site [chemical binding]; other site
1266845001807	Q-loop/lid; other site
1266845001808	ABC transporter signature motif; other site
1266845001809	Walker B; other site
1266845001810	D-loop; other site
1266845001811	H-loop/switch region; other site
1266845001812	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1266845001813	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1266845001814	Walker A/P-loop; other site
1266845001815	ATP binding site [chemical binding]; other site
1266845001816	Q-loop/lid; other site
1266845001817	ABC transporter signature motif; other site
1266845001818	Walker B; other site
1266845001819	D-loop; other site
1266845001820	H-loop/switch region; other site
1266845001821	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1266845001822	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1266845001823	TM-ABC transporter signature motif; other site
1266845001824	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1266845001825	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1266845001826	TM-ABC transporter signature motif; other site
1266845001827	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1266845001828	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1266845001829	putative ligand binding site [chemical binding]; other site
1266845001830	Predicted membrane protein [Function unknown]; Region: COG4129
1266845001831	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1266845001832	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1266845001833	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1266845001834	Bacterial type III secretion protein (HrpB7); Region: HrpB7; pfam09486
1266845001835	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1266845001836	FtsX-like permease family; Region: FtsX; pfam02687
1266845001837	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1266845001838	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1266845001839	FtsX-like permease family; Region: FtsX; pfam02687
1266845001840	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1266845001841	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1266845001842	Walker A/P-loop; other site
1266845001843	ATP binding site [chemical binding]; other site
1266845001844	Q-loop/lid; other site
1266845001845	ABC transporter signature motif; other site
1266845001846	Walker B; other site
1266845001847	D-loop; other site
1266845001848	H-loop/switch region; other site
1266845001849	amino acid transporter; Region: 2A0306; TIGR00909
1266845001850	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1266845001851	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1266845001852	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1266845001853	HI0933-like protein; Region: HI0933_like; pfam03486
1266845001854	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
1266845001855	VanZ like family; Region: VanZ; pfam04892
1266845001856	Predicted flavoprotein [General function prediction only]; Region: COG0431
1266845001857	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1266845001858	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1266845001859	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1266845001860	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1266845001861	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266845001862	putative DNA binding site [nucleotide binding]; other site
1266845001863	putative Zn2+ binding site [ion binding]; other site
1266845001864	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1266845001865	putative deacylase active site [active]
1266845001866	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1266845001867	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1266845001868	putative RNA binding site [nucleotide binding]; other site
1266845001869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266845001870	S-adenosylmethionine binding site [chemical binding]; other site
1266845001871	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1266845001872	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1266845001873	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845001874	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845001875	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845001876	Walker A/P-loop; other site
1266845001877	ATP binding site [chemical binding]; other site
1266845001878	Q-loop/lid; other site
1266845001879	ABC transporter signature motif; other site
1266845001880	Walker B; other site
1266845001881	D-loop; other site
1266845001882	H-loop/switch region; other site
1266845001883	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845001884	non-specific DNA binding site [nucleotide binding]; other site
1266845001885	salt bridge; other site
1266845001886	sequence-specific DNA binding site [nucleotide binding]; other site
1266845001887	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1266845001888	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1266845001889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1266845001890	DinB superfamily; Region: DinB_2; pfam12867
1266845001891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845001892	H+ Antiporter protein; Region: 2A0121; TIGR00900
1266845001893	putative substrate translocation pore; other site
1266845001894	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1266845001895	Helix-turn-helix domain; Region: HTH_38; pfam13936
1266845001896	Integrase core domain; Region: rve; pfam00665
1266845001897	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266845001898	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845001899	non-specific DNA binding site [nucleotide binding]; other site
1266845001900	salt bridge; other site
1266845001901	sequence-specific DNA binding site [nucleotide binding]; other site
1266845001902	VanZ like family; Region: VanZ; pfam04892
1266845001903	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1266845001904	Sulfatase; Region: Sulfatase; pfam00884
1266845001905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266845001906	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1266845001907	dimerization interface [polypeptide binding]; other site
1266845001908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266845001909	dimer interface [polypeptide binding]; other site
1266845001910	phosphorylation site [posttranslational modification]
1266845001911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845001912	ATP binding site [chemical binding]; other site
1266845001913	Mg2+ binding site [ion binding]; other site
1266845001914	G-X-G motif; other site
1266845001915	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266845001916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845001917	active site
1266845001918	phosphorylation site [posttranslational modification]
1266845001919	intermolecular recognition site; other site
1266845001920	dimerization interface [polypeptide binding]; other site
1266845001921	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266845001922	DNA binding site [nucleotide binding]
1266845001923	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1266845001924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1266845001925	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1266845001926	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1266845001927	dimer interface [polypeptide binding]; other site
1266845001928	ssDNA binding site [nucleotide binding]; other site
1266845001929	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1266845001930	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1266845001931	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1266845001932	MreB and similar proteins; Region: MreB_like; cd10225
1266845001933	nucleotide binding site [chemical binding]; other site
1266845001934	Mg binding site [ion binding]; other site
1266845001935	putative protofilament interaction site [polypeptide binding]; other site
1266845001936	RodZ interaction site [polypeptide binding]; other site
1266845001937	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1266845001938	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1266845001939	hinge; other site
1266845001940	active site
1266845001941	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1266845001942	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1266845001943	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1266845001944	gamma subunit interface [polypeptide binding]; other site
1266845001945	epsilon subunit interface [polypeptide binding]; other site
1266845001946	LBP interface [polypeptide binding]; other site
1266845001947	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1266845001948	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1266845001949	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1266845001950	alpha subunit interaction interface [polypeptide binding]; other site
1266845001951	Walker A motif; other site
1266845001952	ATP binding site [chemical binding]; other site
1266845001953	Walker B motif; other site
1266845001954	inhibitor binding site; inhibition site
1266845001955	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1266845001956	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1266845001957	core domain interface [polypeptide binding]; other site
1266845001958	delta subunit interface [polypeptide binding]; other site
1266845001959	epsilon subunit interface [polypeptide binding]; other site
1266845001960	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1266845001961	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1266845001962	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1266845001963	beta subunit interaction interface [polypeptide binding]; other site
1266845001964	Walker A motif; other site
1266845001965	ATP binding site [chemical binding]; other site
1266845001966	Walker B motif; other site
1266845001967	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1266845001968	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1266845001969	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1266845001970	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1266845001971	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1266845001972	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1266845001973	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1266845001974	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1266845001975	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266845001976	active site
1266845001977	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1266845001978	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1266845001979	dimer interface [polypeptide binding]; other site
1266845001980	active site
1266845001981	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1266845001982	folate binding site [chemical binding]; other site
1266845001983	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1266845001984	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1266845001985	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1266845001986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266845001987	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1266845001988	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1266845001989	RF-1 domain; Region: RF-1; pfam00472
1266845001990	thymidine kinase; Provisional; Region: PRK04296
1266845001991	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1266845001992	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1266845001993	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1266845001994	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1266845001995	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1266845001996	catalytic triad [active]
1266845001997	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1266845001998	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1266845001999	Beta-lactamase; Region: Beta-lactamase; pfam00144
1266845002000	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1266845002001	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1266845002002	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1266845002003	putative metal binding site [ion binding]; other site
1266845002004	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1266845002005	active site
1266845002006	metal binding site [ion binding]; metal-binding site
1266845002007	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1266845002008	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845002009	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845002010	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1266845002011	Walker A/P-loop; other site
1266845002012	ATP binding site [chemical binding]; other site
1266845002013	Q-loop/lid; other site
1266845002014	ABC transporter signature motif; other site
1266845002015	Walker B; other site
1266845002016	D-loop; other site
1266845002017	H-loop/switch region; other site
1266845002018	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845002019	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845002020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845002021	Walker A/P-loop; other site
1266845002022	ATP binding site [chemical binding]; other site
1266845002023	Q-loop/lid; other site
1266845002024	ABC transporter signature motif; other site
1266845002025	Walker B; other site
1266845002026	D-loop; other site
1266845002027	H-loop/switch region; other site
1266845002028	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
1266845002029	Ycf48-like protein; Provisional; Region: PRK13684
1266845002030	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1266845002031	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1266845002032	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
1266845002033	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1266845002034	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1266845002035	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1266845002036	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1266845002037	Zn binding site [ion binding]; other site
1266845002038	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1266845002039	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845002040	Zn binding site [ion binding]; other site
1266845002041	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1266845002042	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1266845002043	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1266845002044	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1266845002045	Walker A/P-loop; other site
1266845002046	ATP binding site [chemical binding]; other site
1266845002047	Q-loop/lid; other site
1266845002048	ABC transporter signature motif; other site
1266845002049	Walker B; other site
1266845002050	D-loop; other site
1266845002051	H-loop/switch region; other site
1266845002052	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1266845002053	HPr interaction site; other site
1266845002054	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1266845002055	active site
1266845002056	phosphorylation site [posttranslational modification]
1266845002057	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1266845002058	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1266845002059	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1266845002060	Predicted membrane protein [Function unknown]; Region: COG2855
1266845002061	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1266845002062	aspartate kinase; Reviewed; Region: PRK09034
1266845002063	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1266845002064	putative catalytic residues [active]
1266845002065	putative nucleotide binding site [chemical binding]; other site
1266845002066	putative aspartate binding site [chemical binding]; other site
1266845002067	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1266845002068	allosteric regulatory residue; other site
1266845002069	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1266845002070	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1266845002071	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1266845002072	peptide binding site [polypeptide binding]; other site
1266845002073	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1266845002074	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1266845002075	catalytic residues [active]
1266845002076	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1266845002077	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1266845002078	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1266845002079	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1266845002080	active site
1266845002081	homodimer interface [polypeptide binding]; other site
1266845002082	catalytic site [active]
1266845002083	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1266845002084	homodimer interface [polypeptide binding]; other site
1266845002085	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1266845002086	active site pocket [active]
1266845002087	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1266845002088	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1266845002089	Flagellar protein FliS; Region: FliS; cl00654
1266845002090	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
1266845002091	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1266845002092	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1266845002093	FlaG protein; Region: FlaG; pfam03646
1266845002094	flagellin; Validated; Region: PRK06819
1266845002095	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1266845002096	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1266845002097	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
1266845002098	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1266845002099	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1266845002100	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
1266845002101	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1266845002102	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1266845002103	FlgN protein; Region: FlgN; pfam05130
1266845002104	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
1266845002105	flagellar motor switch protein; Validated; Region: PRK08119
1266845002106	CheC-like family; Region: CheC; pfam04509
1266845002107	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1266845002108	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1266845002109	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1266845002110	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1266845002111	Response regulator receiver domain; Region: Response_reg; pfam00072
1266845002112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845002113	active site
1266845002114	phosphorylation site [posttranslational modification]
1266845002115	intermolecular recognition site; other site
1266845002116	dimerization interface [polypeptide binding]; other site
1266845002117	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1266845002118	CheC-like family; Region: CheC; pfam04509
1266845002119	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1266845002120	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1266845002121	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1266845002122	putative binding surface; other site
1266845002123	active site
1266845002124	P2 response regulator binding domain; Region: P2; pfam07194
1266845002125	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1266845002126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845002127	ATP binding site [chemical binding]; other site
1266845002128	Mg2+ binding site [ion binding]; other site
1266845002129	G-X-G motif; other site
1266845002130	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1266845002131	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1266845002132	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1266845002133	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1266845002134	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1266845002135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845002136	active site
1266845002137	phosphorylation site [posttranslational modification]
1266845002138	intermolecular recognition site; other site
1266845002139	dimerization interface [polypeptide binding]; other site
1266845002140	CheB methylesterase; Region: CheB_methylest; pfam01339
1266845002141	CheD chemotactic sensory transduction; Region: CheD; cl00810
1266845002142	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1266845002143	Cache domain; Region: Cache_1; pfam02743
1266845002144	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1266845002145	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1266845002146	dimer interface [polypeptide binding]; other site
1266845002147	putative CheW interface [polypeptide binding]; other site
1266845002148	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266845002149	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266845002150	active site
1266845002151	catalytic tetrad [active]
1266845002152	Nuclease-related domain; Region: NERD; pfam08378
1266845002153	xanthine permease; Region: pbuX; TIGR03173
1266845002154	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1266845002155	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1266845002156	putative active site [active]
1266845002157	putative FMN binding site [chemical binding]; other site
1266845002158	putative substrate binding site [chemical binding]; other site
1266845002159	putative catalytic residue [active]
1266845002160	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
1266845002161	active site
1266845002162	Ap4A binding cleft/pocket [chemical binding]; other site
1266845002163	P4 phosphate binding site; other site
1266845002164	nudix motif; other site
1266845002165	putative P2/P3 phosphate binding site [ion binding]; other site
1266845002166	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1266845002167	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1266845002168	putative dimer interface [polypeptide binding]; other site
1266845002169	Predicted transcriptional regulators [Transcription]; Region: COG1695
1266845002170	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1266845002171	oligoendopeptidase F; Region: pepF; TIGR00181
1266845002172	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1266845002173	active site
1266845002174	Zn binding site [ion binding]; other site
1266845002175	peptidase T; Region: peptidase-T; TIGR01882
1266845002176	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1266845002177	metal binding site [ion binding]; metal-binding site
1266845002178	dimer interface [polypeptide binding]; other site
1266845002179	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1266845002180	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1266845002181	peptide binding site [polypeptide binding]; other site
1266845002182	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1266845002183	Part of AAA domain; Region: AAA_19; pfam13245
1266845002184	Family description; Region: UvrD_C_2; pfam13538
1266845002185	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1266845002186	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1266845002187	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1266845002188	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1266845002189	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1266845002190	NAD binding site [chemical binding]; other site
1266845002191	substrate binding site [chemical binding]; other site
1266845002192	putative active site [active]
1266845002193	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1266845002194	ArsC family; Region: ArsC; pfam03960
1266845002195	putative catalytic residues [active]
1266845002196	thiol/disulfide switch; other site
1266845002197	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1266845002198	dimanganese center [ion binding]; other site
1266845002199	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1266845002200	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1266845002201	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1266845002202	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1266845002203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1266845002204	Coenzyme A binding pocket [chemical binding]; other site
1266845002205	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1266845002206	Helix-turn-helix domain; Region: HTH_38; pfam13936
1266845002207	Integrase core domain; Region: rve; pfam00665
1266845002208	Integrase core domain; Region: rve_3; cl15866
1266845002209	Predicted membrane protein [Function unknown]; Region: COG2323
1266845002210	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1266845002211	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1266845002212	Isochorismatase family; Region: Isochorismatase; pfam00857
1266845002213	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1266845002214	catalytic triad [active]
1266845002215	conserved cis-peptide bond; other site
1266845002216	Heat induced stress protein YflT; Region: YflT; pfam11181
1266845002217	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1266845002218	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1266845002219	peptide binding site [polypeptide binding]; other site
1266845002220	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1266845002221	EDD domain protein, DegV family; Region: DegV; TIGR00762
1266845002222	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1266845002223	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1266845002224	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1266845002225	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1266845002226	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1266845002227	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1266845002228	putative substrate binding site [chemical binding]; other site
1266845002229	putative ATP binding site [chemical binding]; other site
1266845002230	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1266845002231	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1266845002232	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1266845002233	putative active site [active]
1266845002234	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1266845002235	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1266845002236	NAD binding site [chemical binding]; other site
1266845002237	sugar binding site [chemical binding]; other site
1266845002238	divalent metal binding site [ion binding]; other site
1266845002239	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1266845002240	dimer interface [polypeptide binding]; other site
1266845002241	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1266845002242	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1266845002243	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1266845002244	active site turn [active]
1266845002245	phosphorylation site [posttranslational modification]
1266845002246	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1266845002247	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
1266845002248	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1266845002249	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1266845002250	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1266845002251	Walker A/P-loop; other site
1266845002252	ATP binding site [chemical binding]; other site
1266845002253	Q-loop/lid; other site
1266845002254	ABC transporter signature motif; other site
1266845002255	Walker B; other site
1266845002256	D-loop; other site
1266845002257	H-loop/switch region; other site
1266845002258	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1266845002259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266845002260	dimer interface [polypeptide binding]; other site
1266845002261	conserved gate region; other site
1266845002262	ABC-ATPase subunit interface; other site
1266845002263	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1266845002264	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1266845002265	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1266845002266	active site
1266845002267	metal binding site [ion binding]; metal-binding site
1266845002268	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1266845002269	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1266845002270	Ferritin-like domain; Region: Ferritin; pfam00210
1266845002271	dimerization interface [polypeptide binding]; other site
1266845002272	DPS ferroxidase diiron center [ion binding]; other site
1266845002273	ion pore; other site
1266845002274	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1266845002275	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266845002276	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1266845002277	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266845002278	metal-binding site [ion binding]
1266845002279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845002280	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266845002281	putative substrate translocation pore; other site
1266845002282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845002283	Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949
1266845002284	putative active site [active]
1266845002285	catalytic residue [active]
1266845002286	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1266845002287	putative active site [active]
1266845002288	putative metal binding site [ion binding]; other site
1266845002289	short chain dehydrogenase; Provisional; Region: PRK07109
1266845002290	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1266845002291	putative NAD(P) binding site [chemical binding]; other site
1266845002292	active site
1266845002293	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1266845002294	active site
1266845002295	phosphorylation site [posttranslational modification]
1266845002296	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1266845002297	Mga helix-turn-helix domain; Region: Mga; pfam05043
1266845002298	PRD domain; Region: PRD; pfam00874
1266845002299	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1266845002300	active site
1266845002301	P-loop; other site
1266845002302	phosphorylation site [posttranslational modification]
1266845002303	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1266845002304	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1266845002305	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1266845002306	active site
1266845002307	P-loop; other site
1266845002308	phosphorylation site [posttranslational modification]
1266845002309	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1266845002310	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1266845002311	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1266845002312	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1266845002313	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1266845002314	putative active site [active]
1266845002315	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
1266845002316	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1266845002317	classical (c) SDRs; Region: SDR_c; cd05233
1266845002318	NAD(P) binding site [chemical binding]; other site
1266845002319	active site
1266845002320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1266845002321	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266845002322	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266845002323	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1266845002324	catalytic residues [active]
1266845002325	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1266845002326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1266845002327	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266845002328	active site
1266845002329	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1266845002330	Helix-turn-helix domain; Region: HTH_38; pfam13936
1266845002331	Integrase core domain; Region: rve; pfam00665
1266845002332	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1266845002333	VIT family; Region: VIT1; pfam01988
1266845002334	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1266845002335	active site
1266845002336	oxidoreductase; Provisional; Region: PRK07985
1266845002337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266845002338	NAD(P) binding site [chemical binding]; other site
1266845002339	active site
1266845002340	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1266845002341	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1266845002342	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1266845002343	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1266845002344	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1266845002345	Ligand binding site [chemical binding]; other site
1266845002346	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1266845002347	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1266845002348	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1266845002349	active site
1266845002350	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1266845002351	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1266845002352	ligand binding site [chemical binding]; other site
1266845002353	flexible hinge region; other site
1266845002354	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1266845002355	putative switch regulator; other site
1266845002356	non-specific DNA interactions [nucleotide binding]; other site
1266845002357	DNA binding site [nucleotide binding]
1266845002358	sequence specific DNA binding site [nucleotide binding]; other site
1266845002359	putative cAMP binding site [chemical binding]; other site
1266845002360	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
1266845002361	metal-binding site [ion binding]
1266845002362	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1266845002363	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1266845002364	ligand binding site [chemical binding]; other site
1266845002365	flexible hinge region; other site
1266845002366	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1266845002367	putative switch regulator; other site
1266845002368	non-specific DNA interactions [nucleotide binding]; other site
1266845002369	DNA binding site [nucleotide binding]
1266845002370	sequence specific DNA binding site [nucleotide binding]; other site
1266845002371	putative cAMP binding site [chemical binding]; other site
1266845002372	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1266845002373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845002374	putative metal binding site [ion binding]; other site
1266845002375	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1266845002376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845002377	putative substrate translocation pore; other site
1266845002378	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1266845002379	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1266845002380	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1266845002381	metal binding site [ion binding]; metal-binding site
1266845002382	dimer interface [polypeptide binding]; other site
1266845002383	YibE/F-like protein; Region: YibE_F; pfam07907
1266845002384	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266845002385	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845002386	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1266845002387	Walker A/P-loop; other site
1266845002388	ATP binding site [chemical binding]; other site
1266845002389	Q-loop/lid; other site
1266845002390	ABC transporter signature motif; other site
1266845002391	Walker B; other site
1266845002392	D-loop; other site
1266845002393	H-loop/switch region; other site
1266845002394	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1266845002395	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266845002396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266845002397	Walker A/P-loop; other site
1266845002398	ATP binding site [chemical binding]; other site
1266845002399	Q-loop/lid; other site
1266845002400	ABC transporter signature motif; other site
1266845002401	Walker B; other site
1266845002402	D-loop; other site
1266845002403	H-loop/switch region; other site
1266845002404	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1266845002405	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266845002406	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1266845002407	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1266845002408	active site residue [active]
1266845002409	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266845002410	putative DNA binding site [nucleotide binding]; other site
1266845002411	dimerization interface [polypeptide binding]; other site
1266845002412	putative Zn2+ binding site [ion binding]; other site
1266845002413	Predicted flavoprotein [General function prediction only]; Region: COG0431
1266845002414	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1266845002415	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1266845002416	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845002417	Zn binding site [ion binding]; other site
1266845002418	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1266845002419	Zn binding site [ion binding]; other site
1266845002420	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1266845002421	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845002422	Zn binding site [ion binding]; other site
1266845002423	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1266845002424	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266845002425	Zn binding site [ion binding]; other site
1266845002426	Predicted esterase [General function prediction only]; Region: COG0400
1266845002427	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1266845002428	nucleotide binding site [chemical binding]; other site
1266845002429	domain II; other site
1266845002430	domain IV; other site
1266845002431	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1266845002432	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1266845002433	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1266845002434	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1266845002435	putative active site [active]
1266845002436	putative NTP binding site [chemical binding]; other site
1266845002437	putative nucleic acid binding site [nucleotide binding]; other site
1266845002438	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1266845002439	active site
1266845002440	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1266845002441	active site
1266845002442	putative interdomain interaction site [polypeptide binding]; other site
1266845002443	putative metal-binding site [ion binding]; other site
1266845002444	putative nucleotide binding site [chemical binding]; other site
1266845002445	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1266845002446	domain I; other site
1266845002447	DNA binding groove [nucleotide binding]
1266845002448	phosphate binding site [ion binding]; other site
1266845002449	domain III; other site
1266845002450	catalytic site [active]
1266845002451	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1266845002452	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1266845002453	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1266845002454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266845002455	NAD(P) binding site [chemical binding]; other site
1266845002456	active site
1266845002457	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1266845002458	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1266845002459	substrate binding site [chemical binding]; other site
1266845002460	THF binding site; other site
1266845002461	zinc-binding site [ion binding]; other site
1266845002462	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845002463	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
1266845002464	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266845002465	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266845002466	active site
1266845002467	catalytic tetrad [active]
1266845002468	EDD domain protein, DegV family; Region: DegV; TIGR00762
1266845002469	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1266845002470	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1266845002471	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1266845002472	active site
1266845002473	catalytic site [active]
1266845002474	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1266845002475	Melibiase; Region: Melibiase; pfam02065
1266845002476	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1266845002477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266845002478	dimer interface [polypeptide binding]; other site
1266845002479	conserved gate region; other site
1266845002480	putative PBP binding loops; other site
1266845002481	ABC-ATPase subunit interface; other site
1266845002482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266845002483	dimer interface [polypeptide binding]; other site
1266845002484	conserved gate region; other site
1266845002485	putative PBP binding loops; other site
1266845002486	ABC-ATPase subunit interface; other site
1266845002487	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1266845002488	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1266845002489	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1266845002490	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1266845002491	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1266845002492	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1266845002493	galactokinase; Provisional; Region: PRK05322
1266845002494	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1266845002495	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1266845002496	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1266845002497	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1266845002498	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1266845002499	NAD binding site [chemical binding]; other site
1266845002500	homodimer interface [polypeptide binding]; other site
1266845002501	active site
1266845002502	substrate binding site [chemical binding]; other site
1266845002503	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1266845002504	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1266845002505	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1266845002506	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1266845002507	active site
1266845002508	catalytic residues [active]
1266845002509	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1266845002510	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1266845002511	DNA binding site [nucleotide binding]
1266845002512	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1266845002513	putative ligand binding site [chemical binding]; other site
1266845002514	putative dimerization interface [polypeptide binding]; other site
1266845002515	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1266845002516	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1266845002517	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1266845002518	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1266845002519	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1266845002520	Carbon starvation protein CstA; Region: CstA; pfam02554
1266845002521	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1266845002522	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1266845002523	two-component response regulator; Provisional; Region: PRK14084
1266845002524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845002525	active site
1266845002526	phosphorylation site [posttranslational modification]
1266845002527	intermolecular recognition site; other site
1266845002528	dimerization interface [polypeptide binding]; other site
1266845002529	LytTr DNA-binding domain; Region: LytTR; pfam04397
1266845002530	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1266845002531	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1266845002532	GAF domain; Region: GAF_3; pfam13492
1266845002533	Histidine kinase; Region: His_kinase; pfam06580
1266845002534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845002535	ATP binding site [chemical binding]; other site
1266845002536	Mg2+ binding site [ion binding]; other site
1266845002537	G-X-G motif; other site
1266845002538	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845002539	salt bridge; other site
1266845002540	non-specific DNA binding site [nucleotide binding]; other site
1266845002541	sequence-specific DNA binding site [nucleotide binding]; other site
1266845002542	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1266845002543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266845002544	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1266845002545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266845002546	MFS/sugar transport protein; Region: MFS_2; pfam13347
1266845002547	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1266845002548	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1266845002549	putative active site [active]
1266845002550	catalytic site [active]
1266845002551	AAA domain; Region: AAA_11; pfam13086
1266845002552	Part of AAA domain; Region: AAA_19; pfam13245
1266845002553	AAA domain; Region: AAA_30; pfam13604
1266845002554	AAA domain; Region: AAA_12; pfam13087
1266845002555	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1266845002556	Dynamin family; Region: Dynamin_N; pfam00350
1266845002557	G1 box; other site
1266845002558	GTP/Mg2+ binding site [chemical binding]; other site
1266845002559	G2 box; other site
1266845002560	Switch I region; other site
1266845002561	G3 box; other site
1266845002562	Switch II region; other site
1266845002563	G4 box; other site
1266845002564	G5 box; other site
1266845002565	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1266845002566	G1 box; other site
1266845002567	GTP/Mg2+ binding site [chemical binding]; other site
1266845002568	G2 box; other site
1266845002569	Switch I region; other site
1266845002570	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1266845002571	G3 box; other site
1266845002572	Switch II region; other site
1266845002573	GTP/Mg2+ binding site [chemical binding]; other site
1266845002574	G4 box; other site
1266845002575	G5 box; other site
1266845002576	hypothetical protein; Provisional; Region: PRK11281
1266845002577	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1266845002578	Integrase core domain; Region: rve; pfam00665
1266845002579	short chain dehydrogenase; Provisional; Region: PRK09291
1266845002580	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1266845002581	NADP binding site [chemical binding]; other site
1266845002582	active site
1266845002583	steroid binding site; other site
1266845002584	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1266845002585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266845002586	active site
1266845002587	motif I; other site
1266845002588	motif II; other site
1266845002589	Predicted flavoprotein [General function prediction only]; Region: COG0431
1266845002590	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1266845002591	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1266845002592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266845002593	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1266845002594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266845002595	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1266845002596	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1266845002597	Rrf2 family protein; Region: rrf2_super; TIGR00738
1266845002598	Transcriptional regulator; Region: Rrf2; pfam02082
1266845002599	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1266845002600	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1266845002601	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1266845002602	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1266845002603	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1266845002604	S-formylglutathione hydrolase; Region: PLN02442
1266845002605	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1266845002606	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1266845002607	substrate binding site [chemical binding]; other site
1266845002608	catalytic Zn binding site [ion binding]; other site
1266845002609	NAD binding site [chemical binding]; other site
1266845002610	structural Zn binding site [ion binding]; other site
1266845002611	dimer interface [polypeptide binding]; other site
1266845002612	Predicted transcriptional regulators [Transcription]; Region: COG1733
1266845002613	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1266845002614	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1266845002615	active site
1266845002616	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1266845002617	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1266845002618	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1266845002619	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1266845002620	Substrate-binding site [chemical binding]; other site
1266845002621	Substrate specificity [chemical binding]; other site
1266845002622	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1266845002623	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1266845002624	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1266845002625	putative metal binding residues [ion binding]; other site
1266845002626	signature motif; other site
1266845002627	dimer interface [polypeptide binding]; other site
1266845002628	active site
1266845002629	polyP binding site; other site
1266845002630	substrate binding site [chemical binding]; other site
1266845002631	acceptor-phosphate pocket; other site
1266845002632	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266845002633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266845002634	dimer interface [polypeptide binding]; other site
1266845002635	phosphorylation site [posttranslational modification]
1266845002636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266845002637	ATP binding site [chemical binding]; other site
1266845002638	Mg2+ binding site [ion binding]; other site
1266845002639	G-X-G motif; other site
1266845002640	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266845002641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266845002642	active site
1266845002643	phosphorylation site [posttranslational modification]
1266845002644	intermolecular recognition site; other site
1266845002645	dimerization interface [polypeptide binding]; other site
1266845002646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266845002647	DNA binding site [nucleotide binding]
1266845002648	Predicted transcriptional regulators [Transcription]; Region: COG1695
1266845002649	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1266845002650	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1266845002651	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1266845002652	cytosine deaminase; Provisional; Region: PRK09230
1266845002653	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1266845002654	active site
1266845002655	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
1266845002656	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1266845002657	Na binding site [ion binding]; other site
1266845002658	putative substrate binding site [chemical binding]; other site
1266845002659	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
1266845002660	Uncharacterized conserved protein [Function unknown]; Region: COG2461
1266845002661	Family of unknown function (DUF438); Region: DUF438; pfam04282
1266845002662	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1266845002663	Chorismate mutase type II; Region: CM_2; cl00693
1266845002664	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1266845002665	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1266845002666	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1266845002667	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1266845002668	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1266845002669	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1266845002670	nucleotide binding site [chemical binding]; other site
1266845002671	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1266845002672	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266845002673	DNA-binding site [nucleotide binding]; DNA binding site
1266845002674	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1266845002675	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1266845002676	beta-galactosidase; Region: BGL; TIGR03356
1266845002677	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1266845002678	Melibiase; Region: Melibiase; pfam02065
1266845002679	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1266845002680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266845002681	dimer interface [polypeptide binding]; other site
1266845002682	conserved gate region; other site
1266845002683	putative PBP binding loops; other site
1266845002684	ABC-ATPase subunit interface; other site
1266845002685	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1266845002686	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1266845002687	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1266845002688	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1266845002689	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1266845002690	dimerization interface [polypeptide binding]; other site
1266845002691	putative active cleft [active]
1266845002692	YcxB-like protein; Region: YcxB; pfam14317
1266845002693	YcxB-like protein; Region: YcxB; pfam14317
1266845002694	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1266845002695	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1266845002696	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1266845002697	putative active site [active]
1266845002698	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
1266845002699	Domain of unknown function DUF87; Region: DUF87; pfam01935
1266845002700	AAA-like domain; Region: AAA_10; pfam12846
1266845002701	DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236
1266845002702	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
1266845002703	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1266845002704	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1266845002705	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1266845002706	rRNA binding site [nucleotide binding]; other site
1266845002707	predicted 30S ribosome binding site; other site
1266845002708	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1266845002709	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1266845002710	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1266845002711	RNA binding site [nucleotide binding]; other site
1266845002712	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1266845002713	23S rRNA interface [nucleotide binding]; other site
1266845002714	putative translocon interaction site; other site
1266845002715	signal recognition particle (SRP54) interaction site; other site
1266845002716	L23 interface [polypeptide binding]; other site
1266845002717	trigger factor interaction site; other site
1266845002718	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1266845002719	23S rRNA interface [nucleotide binding]; other site
1266845002720	5S rRNA interface [nucleotide binding]; other site
1266845002721	putative antibiotic binding site [chemical binding]; other site
1266845002722	L25 interface [polypeptide binding]; other site
1266845002723	L27 interface [polypeptide binding]; other site
1266845002724	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1266845002725	30S ribosomal protein S7; Validated; Region: PRK05302
1266845002726	L10 leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845002727	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1266845002728	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845002729	T-box leader; Derived by automated computational analysis using gene prediction method: cmsearch.
1266845002730	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1266845002731	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1266845002732	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266845002733	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1266845002734	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266845002735	dimerization interface [polypeptide binding]; other site
1266845002736	putative DNA binding site [nucleotide binding]; other site
1266845002737	putative Zn2+ binding site [ion binding]; other site
1266845002738	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1266845002739	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1266845002740	Sulfatase; Region: Sulfatase; pfam00884
1266845002741	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1266845002742	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1266845002743	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1266845002744	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1266845002745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266845002746	non-specific DNA binding site [nucleotide binding]; other site
1266845002747	salt bridge; other site
1266845002748	sequence-specific DNA binding site [nucleotide binding]; other site
1266845002749	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1266845002750	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
1266845002751	Initiator Replication protein; Region: Rep_3; pfam01051
1266845002752	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1266845002753	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1266845002754	DNA binding residues [nucleotide binding]
1266845002755	AAA domain; Region: AAA_17; pfam13207
1266845002756	AAA domain; Region: AAA_28; pfam13521
1266845002757	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1266845002758	Int/Topo IB signature motif; other site
1266845002759	Helix-turn-helix domain; Region: HTH_20; pfam12840
1266845002760	putative Zn2+ binding site [ion binding]; other site
1266845002761	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1266845002762	catalytic residues [active]
1266845002763	topology modulation protein; Provisional; Region: PRK07261
1266845002764	AAA domain; Region: AAA_17; pfam13207
1266845002765	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266845002766	active site
1266845002767	DNA binding site [nucleotide binding]
1266845002768	Int/Topo IB signature motif; other site
1266845002769	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877