-- dump date 20140619_025842 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1234679000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 1234679000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1234679000003 putative DNA binding surface [nucleotide binding]; other site 1234679000004 dimer interface [polypeptide binding]; other site 1234679000005 beta-clamp/clamp loader binding surface; other site 1234679000006 beta-clamp/translesion DNA polymerase binding surface; other site 1234679000007 S4 domain; Region: S4_2; pfam13275 1234679000008 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1234679000009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1234679000010 Mg2+ binding site [ion binding]; other site 1234679000011 G-X-G motif; other site 1234679000012 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1234679000013 anchoring element; other site 1234679000014 dimer interface [polypeptide binding]; other site 1234679000015 ATP binding site [chemical binding]; other site 1234679000016 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1234679000017 active site 1234679000018 putative metal-binding site [ion binding]; other site 1234679000019 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1234679000020 DNA gyrase subunit A; Validated; Region: PRK05560 1234679000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1234679000022 CAP-like domain; other site 1234679000023 active site 1234679000024 primary dimer interface [polypeptide binding]; other site 1234679000025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234679000026 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234679000027 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234679000028 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234679000029 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1234679000030 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1234679000031 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1234679000032 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1234679000033 dimer interface [polypeptide binding]; other site 1234679000034 ssDNA binding site [nucleotide binding]; other site 1234679000035 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1234679000036 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1234679000037 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1234679000038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1234679000039 I-site; other site 1234679000040 active site 1234679000041 metal binding site [ion binding]; metal-binding site 1234679000042 DHH family; Region: DHH; pfam01368 1234679000043 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1234679000044 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1234679000045 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1234679000046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1234679000047 Transposase; Region: HTH_Tnp_1; pfam01527 1234679000048 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1234679000049 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1234679000050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1234679000051 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1234679000052 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1234679000053 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1234679000054 Mga helix-turn-helix domain; Region: Mga; pfam05043 1234679000055 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 1234679000056 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1234679000057 Rib/alpha-like repeat; Region: Rib; cl07159 1234679000058 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000059 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000060 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000061 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000062 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000063 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000064 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000065 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000066 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000067 replicative DNA helicase; Provisional; Region: PRK05748 1234679000068 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1234679000069 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1234679000070 Walker A motif; other site 1234679000071 ATP binding site [chemical binding]; other site 1234679000072 Walker B motif; other site 1234679000073 DNA binding loops [nucleotide binding] 1234679000074 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1234679000075 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1234679000076 GDP-binding site [chemical binding]; other site 1234679000077 ACT binding site; other site 1234679000078 IMP binding site; other site 1234679000079 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1234679000080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1234679000081 active site 1234679000082 phosphorylation site [posttranslational modification] 1234679000083 intermolecular recognition site; other site 1234679000084 dimerization interface [polypeptide binding]; other site 1234679000085 PAS domain S-box; Region: sensory_box; TIGR00229 1234679000086 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1234679000087 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1234679000088 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1234679000089 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1234679000090 putative NAD(P) binding site [chemical binding]; other site 1234679000091 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1234679000092 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1234679000093 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1234679000094 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1234679000095 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1234679000096 active site 1234679000097 dimer interface [polypeptide binding]; other site 1234679000098 metal binding site [ion binding]; metal-binding site 1234679000099 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1234679000100 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1234679000101 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1234679000102 endonuclease subunit; Provisional; Region: 46; PHA02562 1234679000103 arginine deiminase; Provisional; Region: PRK01388 1234679000104 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1234679000105 HTH domain; Region: HTH_11; cl17392 1234679000106 Mga helix-turn-helix domain; Region: Mga; pfam05043 1234679000107 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1234679000108 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1234679000109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679000110 catalytic residue [active] 1234679000111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000112 putative substrate translocation pore; other site 1234679000113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1234679000114 Protein of unknown function (DUF975); Region: DUF975; cl10504 1234679000115 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1234679000116 Amidinotransferase; Region: Amidinotransf; cl12043 1234679000117 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1234679000118 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1234679000119 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1234679000120 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1234679000121 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1234679000122 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1234679000123 3D domain; Region: 3D; cl01439 1234679000124 Domain of unknown function DUF21; Region: DUF21; pfam01595 1234679000125 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1234679000126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1234679000127 Transporter associated domain; Region: CorC_HlyC; smart01091 1234679000128 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1234679000129 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1234679000130 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1234679000131 minor groove reading motif; other site 1234679000132 helix-hairpin-helix signature motif; other site 1234679000133 substrate binding pocket [chemical binding]; other site 1234679000134 active site 1234679000135 Predicted membrane protein [Function unknown]; Region: COG1511 1234679000136 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1234679000137 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1234679000138 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1234679000139 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1234679000140 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1234679000141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1234679000142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1234679000143 Coenzyme A binding pocket [chemical binding]; other site 1234679000144 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1234679000145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1234679000146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679000147 homodimer interface [polypeptide binding]; other site 1234679000148 catalytic residue [active] 1234679000149 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1234679000150 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1234679000151 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1234679000152 active site turn [active] 1234679000153 phosphorylation site [posttranslational modification] 1234679000154 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1234679000155 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1234679000156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1234679000157 non-specific DNA binding site [nucleotide binding]; other site 1234679000158 salt bridge; other site 1234679000159 sequence-specific DNA binding site [nucleotide binding]; other site 1234679000160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1234679000161 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1234679000162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1234679000163 dimer interface [polypeptide binding]; other site 1234679000164 conserved gate region; other site 1234679000165 putative PBP binding loops; other site 1234679000166 ABC-ATPase subunit interface; other site 1234679000167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1234679000168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1234679000169 dimer interface [polypeptide binding]; other site 1234679000170 conserved gate region; other site 1234679000171 putative PBP binding loops; other site 1234679000172 ABC-ATPase subunit interface; other site 1234679000173 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1234679000174 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1234679000175 substrate binding pocket [chemical binding]; other site 1234679000176 sugar efflux transporter; Region: 2A0120; TIGR00899 1234679000177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000178 putative substrate translocation pore; other site 1234679000179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1234679000180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1234679000181 substrate binding pocket [chemical binding]; other site 1234679000182 membrane-bound complex binding site; other site 1234679000183 hinge residues; other site 1234679000184 Uncharacterized conserved protein [Function unknown]; Region: COG3542 1234679000185 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1234679000186 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1234679000187 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1234679000188 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1234679000189 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1234679000190 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1234679000191 G1 box; other site 1234679000192 GTP/Mg2+ binding site [chemical binding]; other site 1234679000193 G2 box; other site 1234679000194 Switch I region; other site 1234679000195 G3 box; other site 1234679000196 Switch II region; other site 1234679000197 G4 box; other site 1234679000198 G5 box; other site 1234679000199 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1234679000200 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1234679000201 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1234679000202 putative catalytic cysteine [active] 1234679000203 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1234679000204 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1234679000205 Hexamer interface [polypeptide binding]; other site 1234679000206 Putative hexagonal pore residue; other site 1234679000207 putative oxidoreductase; Provisional; Region: PRK10206 1234679000208 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1234679000209 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1234679000210 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1234679000211 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1234679000212 peptide binding site [polypeptide binding]; other site 1234679000213 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1234679000214 putative active site [active] 1234679000215 catalytic residue [active] 1234679000216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234679000217 RNA binding surface [nucleotide binding]; other site 1234679000218 Septum formation initiator; Region: DivIC; pfam04977 1234679000219 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1234679000220 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1234679000221 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1234679000222 dimer interface [polypeptide binding]; other site 1234679000223 putative anticodon binding site; other site 1234679000224 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1234679000225 motif 1; other site 1234679000226 active site 1234679000227 motif 2; other site 1234679000228 motif 3; other site 1234679000229 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1234679000230 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234679000231 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1234679000232 Walker A/P-loop; other site 1234679000233 ATP binding site [chemical binding]; other site 1234679000234 Q-loop/lid; other site 1234679000235 ABC transporter signature motif; other site 1234679000236 Walker B; other site 1234679000237 D-loop; other site 1234679000238 H-loop/switch region; other site 1234679000239 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1234679000240 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234679000241 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1234679000242 Walker A/P-loop; other site 1234679000243 ATP binding site [chemical binding]; other site 1234679000244 Q-loop/lid; other site 1234679000245 ABC transporter signature motif; other site 1234679000246 Walker B; other site 1234679000247 D-loop; other site 1234679000248 H-loop/switch region; other site 1234679000249 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1234679000250 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1234679000251 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1234679000252 dimer interface [polypeptide binding]; other site 1234679000253 PYR/PP interface [polypeptide binding]; other site 1234679000254 TPP binding site [chemical binding]; other site 1234679000255 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1234679000256 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1234679000257 TPP-binding site [chemical binding]; other site 1234679000258 dimer interface [polypeptide binding]; other site 1234679000259 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1234679000260 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1234679000261 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1234679000262 active site 1234679000263 homotetramer interface [polypeptide binding]; other site 1234679000264 homodimer interface [polypeptide binding]; other site 1234679000265 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1234679000266 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1234679000267 ATP binding site [chemical binding]; other site 1234679000268 Mg++ binding site [ion binding]; other site 1234679000269 motif III; other site 1234679000270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1234679000271 nucleotide binding region [chemical binding]; other site 1234679000272 ATP-binding site [chemical binding]; other site 1234679000273 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1234679000274 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1234679000275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000276 Walker A/P-loop; other site 1234679000277 ATP binding site [chemical binding]; other site 1234679000278 Q-loop/lid; other site 1234679000279 ABC transporter signature motif; other site 1234679000280 Walker B; other site 1234679000281 D-loop; other site 1234679000282 H-loop/switch region; other site 1234679000283 ABC transporter; Region: ABC_tran_2; pfam12848 1234679000284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1234679000285 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1234679000286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000287 Walker A/P-loop; other site 1234679000288 ATP binding site [chemical binding]; other site 1234679000289 Q-loop/lid; other site 1234679000290 ABC transporter signature motif; other site 1234679000291 Walker B; other site 1234679000292 D-loop; other site 1234679000293 H-loop/switch region; other site 1234679000294 TOBE domain; Region: TOBE_2; pfam08402 1234679000295 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1234679000296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1234679000297 dimer interface [polypeptide binding]; other site 1234679000298 conserved gate region; other site 1234679000299 putative PBP binding loops; other site 1234679000300 ABC-ATPase subunit interface; other site 1234679000301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1234679000302 dimer interface [polypeptide binding]; other site 1234679000303 conserved gate region; other site 1234679000304 ABC-ATPase subunit interface; other site 1234679000305 inner membrane transporter YjeM; Provisional; Region: PRK15238 1234679000306 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1234679000307 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1234679000308 putative ligand binding site [chemical binding]; other site 1234679000309 NAD binding site [chemical binding]; other site 1234679000310 catalytic site [active] 1234679000311 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1234679000312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1234679000313 substrate binding pocket [chemical binding]; other site 1234679000314 membrane-bound complex binding site; other site 1234679000315 hinge residues; other site 1234679000316 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1234679000317 Predicted membrane protein [Function unknown]; Region: COG4905 1234679000318 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1234679000319 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1234679000320 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 1234679000321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1234679000322 Cupin domain; Region: Cupin_2; pfam07883 1234679000323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1234679000324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1234679000325 DNA binding site [nucleotide binding] 1234679000326 domain linker motif; other site 1234679000327 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1234679000328 putative dimerization interface [polypeptide binding]; other site 1234679000329 putative ligand binding site [chemical binding]; other site 1234679000330 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1234679000331 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1234679000332 Walker A/P-loop; other site 1234679000333 ATP binding site [chemical binding]; other site 1234679000334 Q-loop/lid; other site 1234679000335 ABC transporter signature motif; other site 1234679000336 Walker B; other site 1234679000337 D-loop; other site 1234679000338 H-loop/switch region; other site 1234679000339 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1234679000340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1234679000341 substrate binding pocket [chemical binding]; other site 1234679000342 membrane-bound complex binding site; other site 1234679000343 hinge residues; other site 1234679000344 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1234679000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1234679000346 dimer interface [polypeptide binding]; other site 1234679000347 conserved gate region; other site 1234679000348 putative PBP binding loops; other site 1234679000349 ABC-ATPase subunit interface; other site 1234679000350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1234679000351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1234679000352 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1234679000353 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1234679000354 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1234679000355 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1234679000356 N- and C-terminal domain interface [polypeptide binding]; other site 1234679000357 active site 1234679000358 catalytic site [active] 1234679000359 metal binding site [ion binding]; metal-binding site 1234679000360 carbohydrate binding site [chemical binding]; other site 1234679000361 ATP binding site [chemical binding]; other site 1234679000362 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1234679000363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1234679000364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1234679000365 YibE/F-like protein; Region: YibE_F; pfam07907 1234679000366 YibE/F-like protein; Region: YibE_F; pfam07907 1234679000367 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1234679000368 heat shock protein HtpX; Provisional; Region: PRK04897 1234679000369 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1234679000370 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1234679000371 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1234679000372 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1234679000373 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1234679000374 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1234679000375 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1234679000376 PemK-like protein; Region: PemK; pfam02452 1234679000377 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1234679000378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1234679000379 S-adenosylmethionine binding site [chemical binding]; other site 1234679000380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000381 D-galactonate transporter; Region: 2A0114; TIGR00893 1234679000382 putative substrate translocation pore; other site 1234679000383 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1234679000384 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1234679000385 metal binding site [ion binding]; metal-binding site 1234679000386 dimer interface [polypeptide binding]; other site 1234679000387 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1234679000388 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1234679000389 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1234679000390 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1234679000391 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1234679000392 active site 1234679000393 substrate binding site [chemical binding]; other site 1234679000394 metal binding site [ion binding]; metal-binding site 1234679000395 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1234679000396 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1234679000397 glutaminase active site [active] 1234679000398 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1234679000399 dimer interface [polypeptide binding]; other site 1234679000400 active site 1234679000401 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1234679000402 dimer interface [polypeptide binding]; other site 1234679000403 active site 1234679000404 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1234679000405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1234679000406 metal binding site [ion binding]; metal-binding site 1234679000407 active site 1234679000408 I-site; other site 1234679000409 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1234679000410 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1234679000411 FtsX-like permease family; Region: FtsX; pfam02687 1234679000412 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1234679000413 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1234679000414 Walker A/P-loop; other site 1234679000415 ATP binding site [chemical binding]; other site 1234679000416 Q-loop/lid; other site 1234679000417 ABC transporter signature motif; other site 1234679000418 Walker B; other site 1234679000419 D-loop; other site 1234679000420 H-loop/switch region; other site 1234679000421 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1234679000422 HlyD family secretion protein; Region: HlyD_3; pfam13437 1234679000423 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1234679000424 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1234679000425 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1234679000426 active site 1234679000427 metal binding site [ion binding]; metal-binding site 1234679000428 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1234679000429 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1234679000430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1234679000431 hypothetical protein; Provisional; Region: PRK04351 1234679000432 SprT homologues; Region: SprT; cl01182 1234679000433 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1234679000434 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1234679000435 Catalytic site [active] 1234679000436 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1234679000437 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1234679000438 putative active site [active] 1234679000439 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1234679000440 active site 1234679000441 P-loop; other site 1234679000442 phosphorylation site [posttranslational modification] 1234679000443 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1234679000444 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1234679000445 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1234679000446 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1234679000447 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1234679000448 methionine cluster; other site 1234679000449 active site 1234679000450 phosphorylation site [posttranslational modification] 1234679000451 metal binding site [ion binding]; metal-binding site 1234679000452 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1234679000453 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1234679000454 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1234679000455 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1234679000456 putative active site [active] 1234679000457 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1234679000458 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1234679000459 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1234679000460 putative active site [active] 1234679000461 catalytic site [active] 1234679000462 putative metal binding site [ion binding]; other site 1234679000463 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234679000464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1234679000465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000466 Walker A/P-loop; other site 1234679000467 ATP binding site [chemical binding]; other site 1234679000468 Q-loop/lid; other site 1234679000469 ABC transporter signature motif; other site 1234679000470 Walker B; other site 1234679000471 D-loop; other site 1234679000472 H-loop/switch region; other site 1234679000473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1234679000474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234679000475 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1234679000476 Walker A/P-loop; other site 1234679000477 ATP binding site [chemical binding]; other site 1234679000478 Q-loop/lid; other site 1234679000479 ABC transporter signature motif; other site 1234679000480 Walker B; other site 1234679000481 D-loop; other site 1234679000482 H-loop/switch region; other site 1234679000483 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1234679000484 NlpC/P60 family; Region: NLPC_P60; pfam00877 1234679000485 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1234679000486 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1234679000487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1234679000488 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1234679000489 Predicted transcriptional regulator [Transcription]; Region: COG1959 1234679000490 Transcriptional regulator; Region: Rrf2; pfam02082 1234679000491 Predicted membrane protein [Function unknown]; Region: COG1511 1234679000492 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1234679000493 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1234679000494 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1234679000495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000496 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1234679000497 Ligand Binding Site [chemical binding]; other site 1234679000498 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1234679000499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000500 putative substrate translocation pore; other site 1234679000501 Predicted transcriptional regulators [Transcription]; Region: COG1695 1234679000502 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1234679000503 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1234679000504 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1234679000505 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1234679000506 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1234679000507 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1234679000508 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1234679000509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679000510 catalytic residue [active] 1234679000511 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1234679000512 Predicted membrane protein [Function unknown]; Region: COG2855 1234679000513 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1234679000514 active site 1234679000515 dimer interface [polypeptide binding]; other site 1234679000516 motif 2; other site 1234679000517 motif 3; other site 1234679000518 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1234679000519 anticodon binding site; other site 1234679000520 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1234679000521 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1234679000522 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1234679000523 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1234679000524 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1234679000525 nucleotide binding site [chemical binding]; other site 1234679000526 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1234679000527 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1234679000528 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1234679000529 putative active site [active] 1234679000530 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1234679000531 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1234679000532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1234679000533 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1234679000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000535 putative substrate translocation pore; other site 1234679000536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234679000537 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1234679000538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000539 Walker A/P-loop; other site 1234679000540 ATP binding site [chemical binding]; other site 1234679000541 Q-loop/lid; other site 1234679000542 ABC transporter signature motif; other site 1234679000543 Walker B; other site 1234679000544 D-loop; other site 1234679000545 H-loop/switch region; other site 1234679000546 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1234679000547 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1234679000548 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1234679000549 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1234679000550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1234679000551 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1234679000552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1234679000553 active site 1234679000554 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1234679000555 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1234679000556 VanZ like family; Region: VanZ; pfam04892 1234679000557 HI0933-like protein; Region: HI0933_like; pfam03486 1234679000558 Sugar transport protein; Region: Sugar_transport; pfam06800 1234679000559 HTH domain; Region: HTH_11; pfam08279 1234679000560 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1234679000561 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1234679000562 active site 1234679000563 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1234679000564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1234679000565 DNA-binding site [nucleotide binding]; DNA binding site 1234679000566 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1234679000567 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1234679000568 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1234679000569 beta-galactosidase; Region: BGL; TIGR03356 1234679000570 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1234679000571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1234679000572 catalytic core [active] 1234679000573 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1234679000574 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1234679000575 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1234679000576 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1234679000577 active site 1234679000578 phosphorylation site [posttranslational modification] 1234679000579 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1234679000580 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1234679000581 tetramer interfaces [polypeptide binding]; other site 1234679000582 binuclear metal-binding site [ion binding]; other site 1234679000583 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1234679000584 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1234679000585 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1234679000586 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1234679000587 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1234679000588 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1234679000589 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1234679000590 active site turn [active] 1234679000591 phosphorylation site [posttranslational modification] 1234679000592 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1234679000593 Predicted membrane protein [Function unknown]; Region: COG2246 1234679000594 GtrA-like protein; Region: GtrA; pfam04138 1234679000595 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1234679000596 Class II fumarases; Region: Fumarase_classII; cd01362 1234679000597 active site 1234679000598 tetramer interface [polypeptide binding]; other site 1234679000599 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1234679000600 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1234679000601 HIGH motif; other site 1234679000602 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1234679000603 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1234679000604 active site 1234679000605 KMSKS motif; other site 1234679000606 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1234679000607 tRNA binding surface [nucleotide binding]; other site 1234679000608 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1234679000609 MULE transposase domain; Region: MULE; pfam10551 1234679000610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1234679000611 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1234679000612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1234679000613 motif II; other site 1234679000614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1234679000616 putative substrate translocation pore; other site 1234679000617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000618 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1234679000619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1234679000620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1234679000621 non-specific DNA binding site [nucleotide binding]; other site 1234679000622 salt bridge; other site 1234679000623 sequence-specific DNA binding site [nucleotide binding]; other site 1234679000624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1234679000625 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1234679000626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1234679000627 non-specific DNA binding site [nucleotide binding]; other site 1234679000628 salt bridge; other site 1234679000629 sequence-specific DNA binding site [nucleotide binding]; other site 1234679000630 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1234679000631 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1234679000632 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1234679000633 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1234679000634 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1234679000635 homodimer interface [polypeptide binding]; other site 1234679000636 substrate-cofactor binding pocket; other site 1234679000637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679000638 catalytic residue [active] 1234679000639 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1234679000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1234679000641 dimer interface [polypeptide binding]; other site 1234679000642 conserved gate region; other site 1234679000643 putative PBP binding loops; other site 1234679000644 ABC-ATPase subunit interface; other site 1234679000645 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1234679000646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000647 Walker A/P-loop; other site 1234679000648 ATP binding site [chemical binding]; other site 1234679000649 Q-loop/lid; other site 1234679000650 ABC transporter signature motif; other site 1234679000651 Walker B; other site 1234679000652 D-loop; other site 1234679000653 H-loop/switch region; other site 1234679000654 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1234679000655 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1234679000656 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1234679000657 THF binding site; other site 1234679000658 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1234679000659 substrate binding site [chemical binding]; other site 1234679000660 THF binding site; other site 1234679000661 zinc-binding site [ion binding]; other site 1234679000662 TraX protein; Region: TraX; cl05434 1234679000663 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1234679000664 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000665 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000666 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000667 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679000668 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1234679000669 Arginine repressor [Transcription]; Region: ArgR; COG1438 1234679000670 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1234679000671 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1234679000672 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1234679000673 active site 1234679000674 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1234679000675 substrate binding site [chemical binding]; other site 1234679000676 metal binding site [ion binding]; metal-binding site 1234679000677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1234679000678 active site 1234679000679 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1234679000680 catalytic tetrad [active] 1234679000681 hypothetical protein; Provisional; Region: PRK13676 1234679000682 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1234679000683 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1234679000684 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1234679000685 generic binding surface II; other site 1234679000686 generic binding surface I; other site 1234679000687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1234679000688 Zn2+ binding site [ion binding]; other site 1234679000689 Mg2+ binding site [ion binding]; other site 1234679000690 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1234679000691 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1234679000692 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1234679000693 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1234679000694 YtxH-like protein; Region: YtxH; pfam12732 1234679000695 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1234679000696 HIT family signature motif; other site 1234679000697 catalytic residue [active] 1234679000698 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1234679000699 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1234679000700 Walker A/P-loop; other site 1234679000701 ATP binding site [chemical binding]; other site 1234679000702 Q-loop/lid; other site 1234679000703 ABC transporter signature motif; other site 1234679000704 Walker B; other site 1234679000705 D-loop; other site 1234679000706 H-loop/switch region; other site 1234679000707 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1234679000708 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1234679000709 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1234679000710 homodimer interface [polypeptide binding]; other site 1234679000711 substrate-cofactor binding pocket; other site 1234679000712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679000713 catalytic residue [active] 1234679000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1234679000716 putative substrate translocation pore; other site 1234679000717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679000718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1234679000719 S-adenosylmethionine binding site [chemical binding]; other site 1234679000720 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1234679000721 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1234679000722 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1234679000723 ATP cone domain; Region: ATP-cone; pfam03477 1234679000724 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1234679000725 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1234679000726 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1234679000727 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1234679000728 active site 1234679000729 dimer interface [polypeptide binding]; other site 1234679000730 motif 1; other site 1234679000731 motif 2; other site 1234679000732 motif 3; other site 1234679000733 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1234679000734 anticodon binding site; other site 1234679000735 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 1234679000736 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1234679000737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1234679000738 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1234679000739 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1234679000740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1234679000741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1234679000742 active site 1234679000743 phosphorylation site [posttranslational modification] 1234679000744 intermolecular recognition site; other site 1234679000745 dimerization interface [polypeptide binding]; other site 1234679000746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1234679000747 DNA binding site [nucleotide binding] 1234679000748 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1234679000749 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1234679000750 Walker A/P-loop; other site 1234679000751 ATP binding site [chemical binding]; other site 1234679000752 Q-loop/lid; other site 1234679000753 ABC transporter signature motif; other site 1234679000754 Walker B; other site 1234679000755 D-loop; other site 1234679000756 H-loop/switch region; other site 1234679000757 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1234679000758 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1234679000759 peptide binding site [polypeptide binding]; other site 1234679000760 hypothetical protein; Provisional; Region: PRK13670 1234679000761 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1234679000762 cell division protein MraZ; Reviewed; Region: PRK00326 1234679000763 MraZ protein; Region: MraZ; pfam02381 1234679000764 MraZ protein; Region: MraZ; pfam02381 1234679000765 MraW methylase family; Region: Methyltransf_5; pfam01795 1234679000766 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1234679000767 Cell division protein FtsL; Region: FtsL; cl11433 1234679000768 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1234679000769 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1234679000770 Mg++ binding site [ion binding]; other site 1234679000771 putative catalytic motif [active] 1234679000772 putative substrate binding site [chemical binding]; other site 1234679000773 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1234679000774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1234679000775 RNA binding surface [nucleotide binding]; other site 1234679000776 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1234679000777 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1234679000778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000779 Walker A/P-loop; other site 1234679000780 ATP binding site [chemical binding]; other site 1234679000781 Q-loop/lid; other site 1234679000782 ABC transporter signature motif; other site 1234679000783 Walker B; other site 1234679000784 D-loop; other site 1234679000785 H-loop/switch region; other site 1234679000786 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1234679000787 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1234679000788 DNA-binding site [nucleotide binding]; DNA binding site 1234679000789 RNA-binding motif; other site 1234679000790 acetolactate synthase; Reviewed; Region: PRK08617 1234679000791 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1234679000792 PYR/PP interface [polypeptide binding]; other site 1234679000793 dimer interface [polypeptide binding]; other site 1234679000794 TPP binding site [chemical binding]; other site 1234679000795 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1234679000796 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1234679000797 TPP-binding site [chemical binding]; other site 1234679000798 dimer interface [polypeptide binding]; other site 1234679000799 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1234679000800 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1234679000801 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1234679000802 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1234679000803 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1234679000804 active site 1234679000805 trimer interface [polypeptide binding]; other site 1234679000806 allosteric site; other site 1234679000807 active site lid [active] 1234679000808 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1234679000809 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1234679000810 dimer interface [polypeptide binding]; other site 1234679000811 ADP-ribose binding site [chemical binding]; other site 1234679000812 active site 1234679000813 nudix motif; other site 1234679000814 metal binding site [ion binding]; metal-binding site 1234679000815 nickel responsive regulator; Provisional; Region: PRK02967 1234679000816 GAD-like domain; Region: GAD-like; pfam08887 1234679000817 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1234679000818 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1234679000819 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1234679000820 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1234679000821 Walker A/P-loop; other site 1234679000822 ATP binding site [chemical binding]; other site 1234679000823 Q-loop/lid; other site 1234679000824 ABC transporter signature motif; other site 1234679000825 Walker B; other site 1234679000826 D-loop; other site 1234679000827 H-loop/switch region; other site 1234679000828 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1234679000829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679000830 Walker A/P-loop; other site 1234679000831 ATP binding site [chemical binding]; other site 1234679000832 Q-loop/lid; other site 1234679000833 ABC transporter signature motif; other site 1234679000834 Walker B; other site 1234679000835 D-loop; other site 1234679000836 H-loop/switch region; other site 1234679000837 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1234679000838 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1234679000839 catalytic triad [active] 1234679000840 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1234679000841 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1234679000842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1234679000843 ABC-ATPase subunit interface; other site 1234679000844 dimer interface [polypeptide binding]; other site 1234679000845 putative PBP binding regions; other site 1234679000846 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1234679000847 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1234679000848 active site 1234679000849 HIGH motif; other site 1234679000850 nucleotide binding site [chemical binding]; other site 1234679000851 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1234679000852 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1234679000853 active site 1234679000854 KMSKS motif; other site 1234679000855 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1234679000856 tRNA binding surface [nucleotide binding]; other site 1234679000857 anticodon binding site; other site 1234679000858 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1234679000859 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1234679000860 DNA-binding site [nucleotide binding]; DNA binding site 1234679000861 RNA-binding motif; other site 1234679000862 rod shape-determining protein MreB; Provisional; Region: PRK13927 1234679000863 MreB and similar proteins; Region: MreB_like; cd10225 1234679000864 nucleotide binding site [chemical binding]; other site 1234679000865 Mg binding site [ion binding]; other site 1234679000866 putative protofilament interaction site [polypeptide binding]; other site 1234679000867 RodZ interaction site [polypeptide binding]; other site 1234679000868 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1234679000869 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1234679000870 Switch I; other site 1234679000871 Switch II; other site 1234679000872 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1234679000873 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1234679000874 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1234679000875 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1234679000876 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1234679000877 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1234679000878 Putative amino acid metabolism; Region: DUF1831; pfam08866 1234679000879 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1234679000880 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1234679000881 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1234679000882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1234679000883 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1234679000884 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1234679000885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1234679000886 active site 1234679000887 motif I; other site 1234679000888 motif II; other site 1234679000889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1234679000890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1234679000891 non-specific DNA binding site [nucleotide binding]; other site 1234679000892 salt bridge; other site 1234679000893 sequence-specific DNA binding site [nucleotide binding]; other site 1234679000894 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1234679000895 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1234679000896 tetramer interface [polypeptide binding]; other site 1234679000897 TPP-binding site [chemical binding]; other site 1234679000898 heterodimer interface [polypeptide binding]; other site 1234679000899 phosphorylation loop region [posttranslational modification] 1234679000900 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1234679000901 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1234679000902 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1234679000903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1234679000904 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1234679000905 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1234679000906 Walker A/P-loop; other site 1234679000907 ATP binding site [chemical binding]; other site 1234679000908 Q-loop/lid; other site 1234679000909 ABC transporter signature motif; other site 1234679000910 Walker B; other site 1234679000911 D-loop; other site 1234679000912 H-loop/switch region; other site 1234679000913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1234679000914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1234679000915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1234679000916 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1234679000917 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1234679000918 active site 1234679000919 ATP binding site [chemical binding]; other site 1234679000920 substrate binding site [chemical binding]; other site 1234679000921 activation loop (A-loop); other site 1234679000922 hypothetical protein; Provisional; Region: PRK11820 1234679000923 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1234679000924 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1234679000925 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1234679000926 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1234679000927 catalytic site [active] 1234679000928 G-X2-G-X-G-K; other site 1234679000929 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1234679000930 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1234679000931 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1234679000932 substrate binding site [chemical binding]; other site 1234679000933 hexamer interface [polypeptide binding]; other site 1234679000934 metal binding site [ion binding]; metal-binding site 1234679000935 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1234679000936 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1234679000937 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1234679000938 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1234679000939 active site 1234679000940 catalytic tetrad [active] 1234679000941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1234679000942 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1234679000943 active site 1234679000944 motif I; other site 1234679000945 motif II; other site 1234679000946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1234679000947 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1234679000948 S1 domain; Region: S1_2; pfam13509 1234679000949 phosphopentomutase; Provisional; Region: PRK05362 1234679000950 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1234679000951 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1234679000952 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1234679000953 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1234679000954 active site 1234679000955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1234679000956 substrate binding site [chemical binding]; other site 1234679000957 catalytic residues [active] 1234679000958 dimer interface [polypeptide binding]; other site 1234679000959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1234679000960 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1234679000961 nucleotide binding site [chemical binding]; other site 1234679000962 N-acetyl-L-glutamate binding site [chemical binding]; other site 1234679000963 aspartate aminotransferase; Provisional; Region: PRK05764 1234679000964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1234679000965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679000966 homodimer interface [polypeptide binding]; other site 1234679000967 catalytic residue [active] 1234679000968 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1234679000969 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1234679000970 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1234679000971 GTP/Mg2+ binding site [chemical binding]; other site 1234679000972 G4 box; other site 1234679000973 G5 box; other site 1234679000974 G1 box; other site 1234679000975 Switch I region; other site 1234679000976 G2 box; other site 1234679000977 G3 box; other site 1234679000978 Switch II region; other site 1234679000979 DNA topoisomerase I; Validated; Region: PRK05582 1234679000980 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1234679000981 active site 1234679000982 interdomain interaction site; other site 1234679000983 putative metal-binding site [ion binding]; other site 1234679000984 nucleotide binding site [chemical binding]; other site 1234679000985 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1234679000986 domain I; other site 1234679000987 DNA binding groove [nucleotide binding] 1234679000988 phosphate binding site [ion binding]; other site 1234679000989 domain II; other site 1234679000990 domain III; other site 1234679000991 nucleotide binding site [chemical binding]; other site 1234679000992 catalytic site [active] 1234679000993 domain IV; other site 1234679000994 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1234679000995 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1234679000996 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1234679000997 Glucose inhibited division protein A; Region: GIDA; pfam01134 1234679000998 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1234679000999 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1234679001000 active site 1234679001001 DNA binding site [nucleotide binding] 1234679001002 Int/Topo IB signature motif; other site 1234679001003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1234679001004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1234679001005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1234679001006 dimerization interface [polypeptide binding]; other site 1234679001007 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 1234679001008 Probable pectinesterase/pectinesterase inhibitor; Provisional; Region: PLN03043 1234679001009 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1234679001010 Integrase core domain; Region: rve; pfam00665 1234679001011 Integrase core domain; Region: rve_3; cl15866 1234679001012 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1234679001013 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1234679001014 zinc binding site [ion binding]; other site 1234679001015 putative ligand binding site [chemical binding]; other site 1234679001016 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1234679001017 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1234679001018 heterodimer interface [polypeptide binding]; other site 1234679001019 active site 1234679001020 FMN binding site [chemical binding]; other site 1234679001021 homodimer interface [polypeptide binding]; other site 1234679001022 substrate binding site [chemical binding]; other site 1234679001023 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1234679001024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1234679001025 active site 1234679001026 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1234679001027 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1234679001028 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1234679001029 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1234679001030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1234679001031 putative substrate translocation pore; other site 1234679001032 POT family; Region: PTR2; cl17359 1234679001033 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1234679001034 active site 1234679001035 catalytic site [active] 1234679001036 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1234679001037 metal binding site 2 [ion binding]; metal-binding site 1234679001038 putative DNA binding helix; other site 1234679001039 metal binding site 1 [ion binding]; metal-binding site 1234679001040 dimer interface [polypeptide binding]; other site 1234679001041 structural Zn2+ binding site [ion binding]; other site 1234679001042 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1234679001043 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1234679001044 dimer interface [polypeptide binding]; other site 1234679001045 motif 1; other site 1234679001046 active site 1234679001047 motif 2; other site 1234679001048 motif 3; other site 1234679001049 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1234679001050 anticodon binding site; other site 1234679001051 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1234679001052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1234679001053 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1234679001054 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1234679001055 argininosuccinate synthase; Provisional; Region: PRK13820 1234679001056 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1234679001057 ANP binding site [chemical binding]; other site 1234679001058 Substrate Binding Site II [chemical binding]; other site 1234679001059 Substrate Binding Site I [chemical binding]; other site 1234679001060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1234679001061 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1234679001062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1234679001063 Walker A/P-loop; other site 1234679001064 ATP binding site [chemical binding]; other site 1234679001065 Q-loop/lid; other site 1234679001066 ABC transporter signature motif; other site 1234679001067 Walker B; other site 1234679001068 D-loop; other site 1234679001069 H-loop/switch region; other site 1234679001070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1234679001071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1234679001072 active site 1234679001073 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1234679001074 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1234679001075 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1234679001076 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1234679001077 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1234679001078 ligand binding site [chemical binding]; other site 1234679001079 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1234679001080 YopX protein; Region: YopX; cl09859 1234679001081 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1234679001082 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1234679001083 active site residue [active] 1234679001084 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1234679001085 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1234679001086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1234679001087 Zn2+ binding site [ion binding]; other site 1234679001088 Mg2+ binding site [ion binding]; other site 1234679001089 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1234679001090 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1234679001091 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1234679001092 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1234679001093 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1234679001094 catalytic residues [active] 1234679001095 catalytic nucleophile [active] 1234679001096 Presynaptic Site I dimer interface [polypeptide binding]; other site 1234679001097 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1234679001098 Synaptic Flat tetramer interface [polypeptide binding]; other site 1234679001099 Synaptic Site I dimer interface [polypeptide binding]; other site 1234679001100 DNA binding site [nucleotide binding] 1234679001101 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1234679001102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1234679001103 DNA-binding site [nucleotide binding]; DNA binding site 1234679001104 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1234679001105 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1234679001106 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1234679001107 active site 1234679001108 HIGH motif; other site 1234679001109 dimer interface [polypeptide binding]; other site 1234679001110 KMSKS motif; other site 1234679001111 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1234679001112 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1234679001113 catalytic residues [active] 1234679001114 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1234679001115 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1234679001116 active site 1234679001117 methionine cluster; other site 1234679001118 phosphorylation site [posttranslational modification] 1234679001119 metal binding site [ion binding]; metal-binding site 1234679001120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1234679001121 non-specific DNA binding site [nucleotide binding]; other site 1234679001122 salt bridge; other site 1234679001123 sequence-specific DNA binding site [nucleotide binding]; other site 1234679001124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1234679001125 sequence-specific DNA binding site [nucleotide binding]; other site 1234679001126 salt bridge; other site 1234679001127 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1234679001128 Catalytic site [active] 1234679001129 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1234679001130 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1234679001131 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1234679001132 catalytic residues [active] 1234679001133 catalytic nucleophile [active] 1234679001134 Recombinase; Region: Recombinase; pfam07508 1234679001135 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1234679001136 putative lipid kinase; Reviewed; Region: PRK13055 1234679001137 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1234679001138 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1234679001139 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1234679001140 GatB domain; Region: GatB_Yqey; smart00845 1234679001141 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1234679001142 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1234679001143 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1234679001144 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1234679001145 putative dimer interface [polypeptide binding]; other site 1234679001146 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1234679001147 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1234679001148 putative dimer interface [polypeptide binding]; other site 1234679001149 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1234679001150 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1234679001151 nucleotide binding pocket [chemical binding]; other site 1234679001152 K-X-D-G motif; other site 1234679001153 catalytic site [active] 1234679001154 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1234679001155 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1234679001156 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1234679001157 Dimer interface [polypeptide binding]; other site 1234679001158 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1234679001159 Part of AAA domain; Region: AAA_19; pfam13245 1234679001160 Family description; Region: UvrD_C_2; pfam13538 1234679001161 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1234679001162 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1234679001163 purine monophosphate binding site [chemical binding]; other site 1234679001164 dimer interface [polypeptide binding]; other site 1234679001165 putative catalytic residues [active] 1234679001166 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1234679001167 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1234679001168 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1234679001169 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1234679001170 active site 1234679001171 substrate binding site [chemical binding]; other site 1234679001172 cosubstrate binding site; other site 1234679001173 catalytic site [active] 1234679001174 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1234679001175 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1234679001176 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1234679001177 MULE transposase domain; Region: MULE; pfam10551 1234679001178 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1234679001179 phosphopentomutase; Provisional; Region: PRK05362 1234679001180 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1234679001181 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1234679001182 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1234679001183 TM-ABC transporter signature motif; other site 1234679001184 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1234679001185 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1234679001186 TM-ABC transporter signature motif; other site 1234679001187 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1234679001188 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1234679001189 Walker A/P-loop; other site 1234679001190 ATP binding site [chemical binding]; other site 1234679001191 Q-loop/lid; other site 1234679001192 ABC transporter signature motif; other site 1234679001193 Walker B; other site 1234679001194 D-loop; other site 1234679001195 H-loop/switch region; other site 1234679001196 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1234679001197 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1234679001198 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1234679001199 ligand binding site [chemical binding]; other site 1234679001200 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1234679001201 active site 1234679001202 catalytic motif [active] 1234679001203 Zn binding site [ion binding]; other site 1234679001204 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1234679001205 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1234679001206 intersubunit interface [polypeptide binding]; other site 1234679001207 active site 1234679001208 catalytic residue [active] 1234679001209 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1234679001210 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1234679001211 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1234679001212 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1234679001213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1234679001214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1234679001215 DNA binding site [nucleotide binding] 1234679001216 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1234679001217 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1234679001218 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1234679001219 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1234679001220 tetramer interface [polypeptide binding]; other site 1234679001221 TPP-binding site [chemical binding]; other site 1234679001222 heterodimer interface [polypeptide binding]; other site 1234679001223 phosphorylation loop region [posttranslational modification] 1234679001224 Predicted esterase [General function prediction only]; Region: COG0400 1234679001225 putative hydrolase; Provisional; Region: PRK11460 1234679001226 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1234679001227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1234679001228 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1234679001229 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1234679001230 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1234679001231 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1234679001232 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1234679001233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1234679001234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1234679001235 Walker A/P-loop; other site 1234679001236 ATP binding site [chemical binding]; other site 1234679001237 Q-loop/lid; other site 1234679001238 ABC transporter signature motif; other site 1234679001239 Walker B; other site 1234679001240 D-loop; other site 1234679001241 H-loop/switch region; other site 1234679001242 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679001243 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679001244 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1234679001245 Mga helix-turn-helix domain; Region: Mga; pfam05043 1234679001246 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1234679001247 active site 1234679001248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1234679001249 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1234679001250 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1234679001251 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1234679001252 nucleotide binding site [chemical binding]; other site 1234679001253 homotetrameric interface [polypeptide binding]; other site 1234679001254 putative phosphate binding site [ion binding]; other site 1234679001255 putative allosteric binding site; other site 1234679001256 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1234679001257 catalytic residue [active] 1234679001258 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1234679001259 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1234679001260 active site 1234679001261 Mga helix-turn-helix domain; Region: Mga; pfam05043 1234679001262 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1234679001263 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1234679001264 NAD(P) binding site [chemical binding]; other site 1234679001265 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1234679001266 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1234679001267 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1234679001268 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1234679001269 metal binding site [ion binding]; metal-binding site 1234679001270 dimer interface [polypeptide binding]; other site 1234679001271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1234679001272 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1234679001273 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1234679001274 Interdomain contacts; other site 1234679001275 Cytokine receptor motif; other site 1234679001276 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1234679001277 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1234679001278 Interdomain contacts; other site 1234679001279 Cytokine receptor motif; other site 1234679001280 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1234679001281 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1234679001282 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1234679001283 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1234679001284 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1234679001285 dimer interface [polypeptide binding]; other site 1234679001286 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1234679001287 dimer interface [polypeptide binding]; other site 1234679001288 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1234679001289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1234679001290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1234679001291 active site 1234679001292 phosphorylation site [posttranslational modification] 1234679001293 intermolecular recognition site; other site 1234679001294 dimerization interface [polypeptide binding]; other site 1234679001295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1234679001296 DNA binding site [nucleotide binding] 1234679001297 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1234679001298 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1234679001299 tetramer interface [polypeptide binding]; other site 1234679001300 heme binding pocket [chemical binding]; other site 1234679001301 NADPH binding site [chemical binding]; other site 1234679001302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1234679001303 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1234679001304 active site 1234679001305 motif I; other site 1234679001306 motif II; other site 1234679001307 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1234679001308 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1234679001309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1234679001310 active site 1234679001311 phosphorylation site [posttranslational modification] 1234679001312 intermolecular recognition site; other site 1234679001313 dimerization interface [polypeptide binding]; other site 1234679001314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1234679001315 DNA binding site [nucleotide binding] 1234679001316 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1234679001317 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1234679001318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1234679001319 catalytic residue [active] 1234679001320 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1234679001321 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1234679001322 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1234679001323 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1234679001324 putative active site [active] 1234679001325 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1234679001326 catalytic residues [active] 1234679001327 putative glycosyl transferase; Provisional; Region: PRK10073 1234679001328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1234679001329 active site 1234679001330 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1234679001331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1234679001332 UDP-galactopyranose mutase; Region: GLF; pfam03275 1234679001333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1234679001334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1234679001335 Coenzyme A binding pocket [chemical binding]; other site 1234679001336 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1234679001337 core dimer interface [polypeptide binding]; other site 1234679001338 peripheral dimer interface [polypeptide binding]; other site 1234679001339 L10 interface [polypeptide binding]; other site 1234679001340 L11 interface [polypeptide binding]; other site 1234679001341 putative EF-Tu interaction site [polypeptide binding]; other site 1234679001342 putative EF-G interaction site [polypeptide binding]; other site 1234679001343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1234679001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1234679001345 active site 1234679001346 phosphorylation site [posttranslational modification] 1234679001347 intermolecular recognition site; other site 1234679001348 dimerization interface [polypeptide binding]; other site 1234679001349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1234679001350 DNA binding site [nucleotide binding] 1234679001351 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1234679001352 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1234679001353 FtsX-like permease family; Region: FtsX; pfam02687 1234679001354 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1234679001355 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1234679001356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1234679001357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1234679001358 DNA binding residues [nucleotide binding] 1234679001359 dimerization interface [polypeptide binding]; other site 1234679001360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1234679001361 Coenzyme A binding pocket [chemical binding]; other site 1234679001362 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1234679001363 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1234679001364 putative hydrophobic ligand binding site [chemical binding]; other site 1234679001365 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1234679001366 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1234679001367 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1234679001368 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1234679001369 Mga helix-turn-helix domain; Region: Mga; pfam05043 1234679001370 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1234679001371 MULE transposase domain; Region: MULE; pfam10551 1234679001372 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1234679001373 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1234679001374 FMN binding site [chemical binding]; other site 1234679001375 active site 1234679001376 substrate binding site [chemical binding]; other site 1234679001377 catalytic residue [active] 1234679001378 short chain dehydrogenase; Provisional; Region: PRK06924 1234679001379 classical (c) SDRs; Region: SDR_c; cd05233 1234679001380 NAD(P) binding site [chemical binding]; other site 1234679001381 active site 1234679001382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1234679001383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1234679001384 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1234679001385 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1234679001386 DNA binding site [nucleotide binding] 1234679001387 domain linker motif; other site 1234679001388 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1234679001389 dimerization interface [polypeptide binding]; other site 1234679001390 ligand binding site [chemical binding]; other site 1234679001391 sodium binding site [ion binding]; other site 1234679001392 chromosome segregation protein; Provisional; Region: PRK02224 1234679001393 threonine dehydratase; Validated; Region: PRK08639 1234679001394 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1234679001395 tetramer interface [polypeptide binding]; other site 1234679001396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1234679001397 catalytic residue [active] 1234679001398 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1234679001399 2-isopropylmalate synthase; Validated; Region: PRK00915 1234679001400 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1234679001401 active site 1234679001402 catalytic residues [active] 1234679001403 metal binding site [ion binding]; metal-binding site 1234679001404 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502